Prof. Dr. Joachim Kirsch Institute for Anatomy and Cell ... - HBIGS
Prof. Dr. Joachim Kirsch Institute for Anatomy and Cell ... - HBIGS
Prof. Dr. Joachim Kirsch Institute for Anatomy and Cell ... - HBIGS
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<strong>Prof</strong>. <strong>Dr</strong>. <strong>Joachim</strong> <strong>Kirsch</strong><br />
<strong>Institute</strong> <strong>for</strong> <strong>Anatomy</strong> <strong>and</strong> <strong>Cell</strong> Biology<br />
University Heidelberg<br />
D-69120 Heidelberg, Germany<br />
Phone: +49-(0)6221-54 8656<br />
Fax: +49-(0)6221-54 4952<br />
E-mail: <strong>Joachim</strong>.kirsch@urz.uni-heidelberg.de<br />
04/05/1958, Homburg <strong>Prof</strong>essor<br />
SCIENTIFIC VITA<br />
1979- 1987 Medical School University Bonn<br />
1981- 1983 Biochemistry at Princeton University, USA<br />
1987 Promotion zum <strong>Dr</strong>. med<br />
1987 – 1990 Dept. of Neurobiology, Weizmann-<strong>Institute</strong> of Science, Rehovot, Israel<br />
1990 – 1991 German Cancer Research Center (DKFZ), Heidelberg<br />
1991 – 1993 Dept. Neurochemistry, Max-Planck-<strong>Institute</strong> <strong>for</strong> Brain Research, Frankfurt<br />
Member of the Scientific Coucil of the Max-Planck-Society<br />
1993 – 1995 Habilitation Center <strong>for</strong> Morphology, University Frankfurt<br />
1995 – 1996 Heisenberg-Grant, Max-Planck-Institut <strong>for</strong> Brain Research, Frankfurt<br />
1996 – 1998 Schilling-<strong>Prof</strong>essor, Max-Planck-Institut <strong>for</strong> Brain Research, Frankfurt<br />
1998 - Appointment as Full <strong>Prof</strong>essor <strong>and</strong> Chairman<br />
1998 – 2002 Director Dept. Abteilung Anatomie & cellular Neurobiology, University of Ulm,<br />
Dean of Studies<br />
2002 - Director Dept. of Medical <strong>Cell</strong> Biology <strong>Institute</strong> <strong>for</strong> <strong>Anatomy</strong> <strong>and</strong> <strong>Cell</strong> Biology,<br />
University Heidelberg<br />
FIELDS OF INTEREST<br />
Molecular Basis of the ontogeny of inhibitory <strong>and</strong> excitatory synapses,<br />
membrane cytoskeleton interactions,<br />
activity dependent signalling pathways in nerve cells<br />
principles of cellular compartmentalization<br />
FUNDED PROJECTS<br />
10 DFG, 1 EU, 1 German-Israeli Foundation<br />
Supervision of a 10 completed doctoral theses, 1 habilitation theses, Ongoing supervision: 2<br />
diploma theses, 3 doctoral theses, 3 habilitation theses
PUBLICATIONS (10 selected publications since 2000):<br />
Nawrotzki, R., Kirstein, M., Knöpfle, K., <strong>Kirsch</strong>, J. 2004. Alternative splicing of gephyrin<br />
controls the collybistin-mediated targeting to the cell surface. (submitted)<br />
Schmidt, E., Corvey, C., Janista, C., Karas, M., <strong>Kirsch</strong>, J., Kuhse, J. The glycine receptor is<br />
involved in the regulation of the RAFT/mTOR signaling pathway. (submitted)<br />
Xiang, S., Nassar, N., <strong>Kirsch</strong>, J., Schindelin, H. Insights into Collybistin Function from the<br />
Crystal Structure of the Cdc42-Collybistin II Complex. (submitted)<br />
von Boyen, G.B., Steinkamp, M., Geerling, I., Reinshagen, M., Schäfer, K-H., Adler, G.,<br />
<strong>Kirsch</strong>, J. Enteric glia secrete neurotrophic factors upon stimulation with proinflammatory<br />
cytokines: a possible role <strong>for</strong> gut protection during inflammation (submitted)<br />
von Boyen, G.B., Steinkamp, M., Reinshagen, M., Schäfer, K., Adler, G., <strong>Kirsch</strong>, J. 2004.<br />
Proinflammatory cytokines increase GFAP expression in enteric glia. Gut 53: 222–228.<br />
Giesemann, K., Schwarz, G., Mendel, R.R., Nawrotzki , R., <strong>Kirsch</strong>, J., Jockusch, B. 2003.<br />
Complex <strong>for</strong>mation between the postsynaptic scaffolding protein gephyrin profilin <strong>and</strong> MENA:<br />
a possible link to the microfilament system. J. Neurosci 23: 8330-8339.<br />
Fuhrmann, J.C., Kins, S., Rostaing, P., El Far, O., <strong>Kirsch</strong>, J., Sheng, M., Triller, A., Betz, H.,<br />
Kneussel, M. 2002. Gephyrin interacts with Dynein light chains 1 <strong>and</strong> 2, components of<br />
motor protein complexes. J. Neurosci 22: 5393-5402.<br />
Jess, U., El Far, O., <strong>Kirsch</strong>, J., Betz, H. 2002. Interaction of the C-terminal region of the rat<br />
serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase<br />
C. Biochem Biophys Res Commun 294: 272-279.<br />
Kins, S., Betz, H., <strong>Kirsch</strong>, J. 2000. Collybistin, a newly identified brain-specific GEF, induces<br />
submembrane clustering of gephyrin. Nat Neurosci 3: 22-29.<br />
Ramming, M., Kins, S., Werner, N., Hermann, A., Betz, H., <strong>Kirsch</strong>, J. 2000. Diversity <strong>and</strong><br />
phylogeny of gephyrin: tissue-specific splice variants, gene structure, <strong>and</strong> sequence<br />
similarities to molybdenum cofactor-synthesizing <strong>and</strong> cytoskeleton-associated proteins. Proc<br />
Natl Acad Sci USA 97: 10266-10271.<br />
Simburger, E., Plaschke, M., <strong>Kirsch</strong>, J., Nitsch, R. 2000. Distribution of the receptoranchoring<br />
protein gephyrin in the rat dentate gyrus <strong>and</strong> changes following entorhinal cortex<br />
lesion. Cereb Cortex 10: 422-432.<br />
Reviews<br />
von Boyen, G.B., Reinshagen, M., Steinkamp, M., Adler, G., <strong>Kirsch</strong>, J. 2002. Enteric<br />
nervous plasticity <strong>and</strong> development: dependence on neurotrophic factors. J Gastroenterol<br />
37: 583-588.<br />
von Boyen, G.B., Reinshagen, M., Steinkamp, M., Adler, G., <strong>Kirsch</strong>, J. 2002. Gut<br />
inflammation modulated by the enteric nervous system <strong>and</strong> neurotrophic factors. Sc<strong>and</strong> J<br />
Gastroenterol 37: 621-625.
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