Lecture 7: Reproductive and Developmental Toxicology (Yager)
Lecture 7: Reproductive and Developmental Toxicology (Yager)
Lecture 7: Reproductive and Developmental Toxicology (Yager)
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<strong>Developmental</strong> Toxicity<br />
• Type I changes<br />
Endpoints<br />
– Outcomes permanent, life-threatening <strong>and</strong><br />
frequently associated with gross<br />
malformations<br />
• Reduction of number of live births<br />
(litter size)<br />
• Increased number of stillbirths<br />
• Increased number of resorptions<br />
• Increased number of fetuses with<br />
malformations<br />
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