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Lecture 7: Reproductive and Developmental Toxicology (Yager)

Lecture 7: Reproductive and Developmental Toxicology (Yager)

Lecture 7: Reproductive and Developmental Toxicology (Yager)

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Diethylstilbesterol (DES)<br />

• Mechanisms of DES toxicity: Critical period<br />

for estrogen exposure—toxicity window<br />

Estrogen Concentration<br />

Human<br />

CP<br />

1 2 3<br />

Pregnancy (trimester)<br />

50

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