Lecture 7: Reproductive and Developmental Toxicology (Yager)
Lecture 7: Reproductive and Developmental Toxicology (Yager)
Lecture 7: Reproductive and Developmental Toxicology (Yager)
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Thailomide Syndrome<br />
Specie<br />
Cynomolgous monkey<br />
(crab eating)<br />
Macoca fascicularis<br />
Rhesus monkey<br />
M. mulatta<br />
Stump-tailed monkey<br />
M. arciodes<br />
Bonnet monkey<br />
M. radiata<br />
Japanese monkey<br />
M. fuscata<br />
Thalidomide Teratogenesis in Primates<br />
Teratogenic Gestation<br />
dose mg/mg days<br />
(oral) treated<br />
Offspring with<br />
defects (type 1)<br />
10 22-32 6/7 Limbs,<br />
teratomas<br />
12 24-30 3/6 Limbs<br />
5 24-30 5/5 Limbs <strong>and</strong> tail<br />
5 24-44 13/2<br />
9<br />
Limbs <strong>and</strong><br />
visceral<br />
20 24-26 6/6 Limbs, tail <strong>and</strong><br />
CNS<br />
73
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