Lecture 7: Reproductive and Developmental Toxicology (Yager)

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Diethylstilbesterol (DES) • Menstrual irregularities • Possible adverse pregnancy outcomes including spontaneous abortions, ectopic pregnancies, <strong>and</strong> premature delivery • Possible increased risk for breast cancer (recent) 48
Diethylstilbesterol (DES) • Effects of in utero exposure on human male progeny – Anatomic abnormalities of the reproductive tract – Altered semen including decreased sperm density, count, <strong>and</strong> motility – Neoplasms of the reproductive tract not widely reported 49
Page 1 and 2: This work is licensed under a Creat
Page 3 and 4: Outline • Introduction and genera
Page 5 and 6: Frequencies of Selected Reproductiv
Page 7 and 8: Reproductive Toxins: Drugs, Environ
Page 9 and 10: Neuroendocrine Targets for Reproduc
Page 11 and 12: Reproductive Tissue: Testis/Seminif
Page 13 and 14: Reproductive Tissue Form the Blood-
Page 15 and 16: Primary Follicle This section is fr
Page 17 and 18: Reproductive Tissue - Ovary Number
Page 19 and 20: Reproductive Toxicity Endpoints - I
Page 21 and 22: Causes of Birth Defects A birth def
Page 23 and 24: Causes of Birth Defects Drugs, chem
Page 25 and 26: Toxic Windows: Stages of Embryogene
Page 27 and 28: Human Developmental Toxicants • R
Page 29 and 30: Human Developmental Toxicants • C
Page 31 and 32: Distribution of Xenobiotics Between
Page 33 and 34: Developmental Toxicity • Type II
Page 35 and 36: Section C 1,2-Dibromo-3-Chloropropa
Page 37 and 38: 1,2-Dibromo-3-Chrolopropane (DBCP):
Page 39 and 40: Neuroendocrine Feedback Hypothalamu
Page 41 and 42: Section D Estrogens
Page 43 and 44: Diethylstilbesterol (DES) • Clini
Page 45 and 46: Diethylstilbesterol (DES) Incidence
Page 47: Diethylstilbesterol (DES) • Struc
Page 51 and 52: Metabolism of Diethylstilbesterol (
Page 53 and 54: Estrogenicity of DES • DES is a p
Page 55 and 56: Environmental Endocrine Disruptors
Page 57 and 58: Environmental Estrogens Adverse rep
Page 63 and 64: Structure and Uses • Structure 63
Page 65 and 66: Comparison to Other Sedatives Compa
Page 67 and 68: Discovery of Side Effects 67
Page 69 and 70: Congenital Malformations Attributed
Page 71 and 72: The Thalidomide Syndrome Period of
Page 73 and 74: Thailomide Syndrome Specie Cynomolg
Page 75 and 76: Mechanisms of Action • Metabolism
Page 77 and 78: Current Clinical Uses - Seems to cu

Lecture 7: Reproductive and Developmental Toxicology (Yager)

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