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15th Annual Scientific Meeting - Heart Failure Society of America

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Sept. 19<br />

Monday<br />

Posters<br />

Posters<br />

Cardiovascular Physiology<br />

Posters<br />

Cardiovascular Physiology<br />

Sept. 19<br />

Monday<br />

Posters<br />

MondAY<br />

016 Interferon Regulatory Factor-3 (IRF-3) as a Potential<br />

Therapeutic Target To Prevent Myocyte Apoptosis and<br />

Promote Angiogenesis in Post-Myocardial Infarction<br />

Remodeling<br />

Ge<strong>of</strong>frey de Couto 1 , William Stanford 1 , Scott Heximer 1 , Jeffrey<br />

Medin 1 , Peter Liu 1 ; 1 University <strong>of</strong> Toronto, Toronto, ON, Canada<br />

017 Impaired Dobutamine Augmentation <strong>of</strong> Early Diastolic<br />

Suction in Diastolic Dysfunction<br />

Takahiro Ohara 1 , Cassie L. Niebel 2 , Kelley C. Stewart 2 , John J.<br />

Charonko 2 , Pamela R. Burgess 1 , Min Pu 1 , Pavlos P. Vlachos 2 ,<br />

William C. Little 1 ; 1 Cardiology Section, Wake Forest University<br />

School <strong>of</strong> Medicine, Winston-Salem, NC; 2 Department <strong>of</strong><br />

Mechanical Engineering, Virginia Tech, Blacksburg, VA<br />

018 The GRK2 Inhibitor βARKct Enhances β2-Adrenergic<br />

Receptor-Dependent Cardiac Contractility In Vivo by<br />

Opposing Receptor Interaction with Phosphodiesterase<br />

Type 4D<br />

Anastasios Lymperopoulos 1,2 , Giuseppe Rengo 2,3 , Erhe Gao 2 ,<br />

Walter J. Koch 2 ; 1 Pharmaceutical Sciences/College <strong>of</strong> Pharmacy,<br />

Nova Southeastern University, Fort Lauderdale, FL; 2 Center<br />

for Translational Medicine, Thomas Jefferson University,<br />

Philadelphia, PA; 3 University Federico II, Naples, Italy<br />

019 Diminished Global Arginine Bioavailability as a<br />

Metabolic Defect in Chronic <strong>Heart</strong> <strong>Failure</strong> in the Setting<br />

<strong>of</strong> Preserved Renal Function<br />

Kevin Shrestha 1 , Zhili Shao 1 , Allen G. Borowski 1 , Richard W.<br />

Troughton 2 , Allan L. Klein 2 , W.H. Wilson Tang 1 ; 1 Cleveland<br />

Clinic, Cleveland, OH; 2 Christchurch School <strong>of</strong> Medicine and<br />

Health Sciences, Christchurch, New Zealand<br />

020 TWIST-1 and Its Target, the miR 199/214 Cluster, Are<br />

Down-Regulated in Dilated Cardiomyopathy Resulting<br />

in Increased Proteasome Activity in Human Myocardium<br />

Anna Baumgarten 1 , Claudia Bang 2 , Reinhard Pregla 3 , Anika<br />

Tschirner 1 , Volker Adams 4 , Rudolf Meyer 3 , Thomas Thum 2 ,<br />

Roland Hetzer 3 , Stefan D. Anker 1 , Jochen Springer 1 ; 1 Applied<br />

Cachexia Research, CCR, Charite Medical School, Berlin,<br />

Germany; 2 Institute for Molecular and Translational Therapeutic<br />

Strategies, Medical School Hannover, Hannover, Germany;<br />

3<br />

DHZB, Berlin, Germany; 4 <strong>Heart</strong> Center Leipzig, Leipzig,<br />

Germany<br />

021 Nebulette Mutations Augment Cardiomyocyte Calcium<br />

Signaling through Modification <strong>of</strong> the Thin Filament in<br />

Preclinical Inherited Dilated Cardiomyopathy<br />

Kathryn M. Rafferty 1 , Evangalia G. Kranias 2 , Jeanne James 1 ,<br />

Jeffrey A. Towbin 1 , Enkhsaikhan Purevjav 1 ; 1 The <strong>Heart</strong> Institute,<br />

Cincinnati Childrens Hospital Medical Center, Cincinnati, OH;<br />

2<br />

Department <strong>of</strong> Pharmacology Cell Biophysics, University <strong>of</strong><br />

Cincinnati, Cincinnati, OH<br />

58<br />

022 Association between VE-VCO2 Slope and Resting<br />

Hemodynamic Measurements in Ambulatory <strong>Heart</strong><br />

<strong>Failure</strong> (HF) Patients: An Analysis from the Duke<br />

Advanced HF Database<br />

C. Patel 1 , R.J. Mentz 1 , J. Suarez 1 , A.F. Hernandez 1 , G.M. Felker 1 ,<br />

C.M. O’Connor 1 , J.G. Rogers 1 ; 1 Duke University, Durham, NC<br />

023 Obese Patients with Equivalent NYHA Have Less<br />

Cardiac Impairment Than Non-Obese Counterparts<br />

Shanmugakumar Chinnappa 1 , Nigel Lewis 1 , David Goldspink 2 ,<br />

Diane Barker 1 , Lip-Bun Tan 1 ; 1 Leeds Teaching Hospitals NHS<br />

Trust, Leeds, United Kingdom; 2 University <strong>of</strong> Leeds, Leeds,<br />

United Kingdom<br />

024 Fat Measurement and Functional Characteristics in<br />

<strong>Heart</strong> <strong>Failure</strong> Patients<br />

A. Zavin 1 , K. Allsup 1 , D.R. Gagnon 6,7 , R. Arena 4 , S. Davis 1 , J.<br />

Joseph 1,2 , S. Lecker 2 , A. Lazzari 1,3 , P.C. Schulze 5 , D.E. Forman 1,2 ;<br />

1<br />

VA Boston Healthcare System, Boston; 2 Harvard Medical<br />

School, Boston, MA; 3 Boston University School <strong>of</strong> Medicine,<br />

Boston, MA; 4 University <strong>of</strong> New Mexico, Albuquerque,<br />

NM; 5 Columbia University Medical Center, New York, NY;<br />

6<br />

Boston University SPH, Boston, MA; 7 VA Cooperative Studies<br />

Program, Boston, MA<br />

025 Pacing from a Novel Quadripolar LV Lead Improves LV<br />

Synchrony in CRT Patients<br />

Gery F. Tomassoni 1 , Melody Muir 1 , Erin O’Brien 2 , Kyungmoo<br />

Ryu 2 , Aaron Hesselson 1 ; 1 Lexington Cardiology Consultants,<br />

Lexington, KY; 2 St. Jude Medical, Sylmar, CA<br />

026 Hematological Malignancies Are Associated with<br />

Significant Elevations in N-Terminal Pro Brain<br />

Natriuretic Peptide<br />

Jesal Popat 1 , Abel Rivero 1 , Maya Guglin 1 ; 1 Department <strong>of</strong><br />

Cardiovascular Medicine, University <strong>of</strong> South Florida, Tampa,<br />

FL<br />

027 In Vitro and In Vivo Actions <strong>of</strong> a Novel ANP Genetic<br />

Variant: Unique Actions on Human Endothelial Cells<br />

Valentina Cannone 1 , Brenda K. Huntley 1 , Guido Boerrigter 1 ,<br />

Alessandro Cataliotti 1 , Denise M. Heublein 1 , John C. Burnett,<br />

Jr. 1 ; 1 Cardiorenal Research Laboratory, Mayo Clinic, Rochester,<br />

MN<br />

028 Left Atrial Diastolic Dysfunction, an Underappreciated<br />

Cause <strong>of</strong> Pulmonary Venous Hypertension and<br />

Decompensated <strong>Heart</strong> <strong>Failure</strong><br />

Hemal H. Kadakia 1 , Soheni Channah 1 , James T. Heywood 1 ,<br />

Allen D. Johnson 1 , Douglas N. Gibson 1 , Michael R. Smith 1 ,<br />

Tariq Khan 1 ; 1 Cardiology, Scripps Clinic, San Diego, CA<br />

59<br />

MondAY

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