Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
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TagLite – results<br />
Correlation with other methods<br />
Biological activity -<br />
BLT assay<br />
FcgRIIIaF158<br />
‣ The BLT assay measures the release of esterase upon activation of NK cells<br />
‣ The graph shows that the 2 IgGs containing higher a-fuc degree lead to a 3 fold higher release of<br />
esterase than the ones with lower a-fuc degree.<br />
‣ The release correlates well with killing of the target cell.<br />
Sylvia Herter, <strong>Roche</strong> Glycart AG<br />
16
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