Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
Presentation_Grau(Roche)_Miptec 2011_ ... - Cisbio Bioassays
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Introduction<br />
Glycoengineering<br />
Engineering cell lines overexpressing GnTIII<br />
N-linked glycosylation<br />
high<br />
mannose<br />
GnT-III<br />
competes against<br />
a1,6-FuT<br />
bisected<br />
non-fucosylated<br />
GnT-I<br />
Asn<br />
ManII and GnT-II<br />
hybrid<br />
ManII<br />
GnT-III<br />
a1,6FuT<br />
bisected<br />
hybrid<br />
GnT-II<br />
a1,6FuT<br />
complex<br />
GnT-III<br />
a1,6FuT<br />
Asn<br />
bisected<br />
complex<br />
Why has the presence of the fucose<br />
such a great impact on binding?<br />
N-acetylglucosamine (GlcNAc)<br />
Mannose<br />
Fucose<br />
Picture taken from Claudia Ferrara, <strong>Roche</strong> Glycart AG<br />
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