Ex vivo modeling of HIV persistence in successfully treated subjects ...
Ex vivo modeling of HIV persistence in successfully treated subjects ...
Ex vivo modeling of HIV persistence in successfully treated subjects ...
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HPDA: Identify<strong>in</strong>g novel antiviral compounds<br />
Viral production<br />
(<strong>HIV</strong> RNA copies)<br />
10000<br />
1000<br />
100<br />
10<br />
DMSO<br />
dCA 100nM<br />
1<br />
A B C D<br />
Virally suppressed <strong>subjects</strong><br />
dCA <strong>in</strong>hibits spontaneous viral release from persistently <strong>in</strong>fected cells from virally<br />
suppressed <strong>subjects</strong>.<br />
HPDA allows the evaluation <strong>of</strong> antiviral compounds aimed at affect<strong>in</strong>g ongo<strong>in</strong>g viral<br />
production that persists under HAART.
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