Ex vivo modeling of HIV persistence in successfully treated subjects ...
Ex vivo modeling of HIV persistence in successfully treated subjects ...
Ex vivo modeling of HIV persistence in successfully treated subjects ...
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• Current methods to study <strong>HIV</strong> latency:<br />
- Cell l<strong>in</strong>es<br />
- Primary human cells (Bosque, Blood 2009; Mar<strong>in</strong>i, JI 2008; Tyagi, JV 2010;<br />
Swiggard, JV 2005; Saleh, Blood 2007; Yang, JCI 2009)<br />
- Cells from virally suppressed <strong>subjects</strong> (Reuse, PLoS One 2009;<br />
Blazkova, JID 2012)<br />
Current tools<br />
• Current assays to measure <strong>HIV</strong> <strong>persistence</strong>:<br />
- <strong>HIV</strong> DNA<br />
- Cell-associated <strong>HIV</strong> RNA<br />
- Co-culture assay (IUPM)<br />
- S<strong>in</strong>gle Copy Assay (SCA)
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