Ex vivo modeling of HIV persistence in successfully treated subjects ...

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Evaluative tools for an HIV cure Crucial need to develop powerful tools: • To test novel therapeutic strategies • To predict their clinical outcome • To evaluate their capacity to eliminate latently infected cells
• Current methods to study HIV latency: - Cell lines - Primary human cells (Bosque, Blood 2009; Marini, JI 2008; Tyagi, JV 2010; Swiggard, JV 2005; Saleh, Blood 2007; Yang, JCI 2009) - Cells from virally suppressed subjects (Reuse, PLoS One 2009; Blazkova, JID 2012) Current tools • Current assays to measure HIV persistence: - HIV DNA - Cell-associated HIV RNA - Co-culture assay (IUPM) - Single Copy Assay (SCA)
Page 1: “Towards an HIV Cure” Pre-Confe
Page 5 and 6: HPDA: Measuring the HIV reservoir s
Page 7 and 8: HPDA: Measuring the HIV reservoir s
Page 9 and 10: HPDA: Identifying reactivation stra
Page 11 and 12: HPDA: Identifying novel antiviral c
Page 13 and 14: Conclusions • Therapeutic strateg
Page 15: Acknowledgement Volunteers Claire V

Ex vivo modeling of HIV persistence in successfully treated subjects ...

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