Molecular and cellular changes in acute kidney injury

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Effect of Decreased AGER1 After a AGE over-load A Low AGE Diet Prevents Kidney Disease of Aging and a Single Oral AGE (MG-H1) Promotes CKD of Aging in (24 mo C57BL6 mice) A. Low AGE Diet B. AGE (MG)-Supplemented Diet Thus, AGEs cause ROS/Inflammation, Kidney Disease, and Also Lead to CVD, etc.! 12 Zheng, Vlassara, Striker, AmJPath 2009
AKI and Baseline ROS • Baseline Levels of ROS and Inflammation Determine The Amount and Type of Responses to an Oxidative Stress or Inflammatory Insult (toxins, metabolic). • Since toxins and DM Increase the Levels of ROS/Inflammation, the Subsequent Response Depends on Baseline Levels. • Tested using Tunicamycin to induce ER stress and by Inducing T1D in Young (Low ROS) and Old (High ROS) Mice. 13
Page 1 and 2: Acute Kidney Injury in Aging The Ro
Page 3 and 4: AGEs are one Major Source of Oxidan
Page 5 and 6: AGER1 at the Cell Surface Controls
Page 7 and 8: AGER1 and the OST Complex • Misfo
Page 9 and 10: Serum AGEs and Renal Function are L
Page 11: Restoration of AGER1 by Reduced AGE
Page 15 and 16: Nephropathy Only with High OS/Infl
Page 17 and 18: Blocking ER Stress Pathways Blocks
Page 19 and 20: So, What Constitutes High AGE Intak
Page 21: Mt. Sinai School of Medicine Team D

Molecular and cellular changes in acute kidney injury

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