Molecular and cellular changes in acute kidney injury

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Summary • Pre-Existing Levels of OS and Inflammation Determine the Amount and Type of Response to AKI (due to Toxins, DN). • Since control of OS/Inflammation is critical in AKI, Pre-Existing OS should be recognized and treated first. • OS/Inflammation can be Reduced (with drugs and/or Low-AGE Diet). • Best Option? A Combination of Drugs and Control of AGE Intake. 18
So, What Constitutes High AGE Intake? Heat-Processed Foods . The Good News: A 50% decrease may be Sufficient! No Changes in Calorie or Nutrient Consumption 19
Page 1 and 2: Acute Kidney Injury in Aging The Ro
Page 3 and 4: AGEs are one Major Source of Oxidan
Page 5 and 6: AGER1 at the Cell Surface Controls
Page 7 and 8: AGER1 and the OST Complex • Misfo
Page 9 and 10: Serum AGEs and Renal Function are L
Page 11 and 12: Restoration of AGER1 by Reduced AGE
Page 13 and 14: AKI and Baseline ROS • Baseline L
Page 15 and 16: Nephropathy Only with High OS/Infl
Page 17: Blocking ER Stress Pathways Blocks
Page 21: Mt. Sinai School of Medicine Team D

Molecular and cellular changes in acute kidney injury

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