evaluation of certain food additives - libdoc.who.int - World Health ...

proportion of consumers in this group was higher. In all these studies, the
beverages covered by Food Category 14.1.4 had provisions for cyclamates.
In the one submission from Australia, three analyses were performed:
1) The first assumed Codex GSFA maximum use levels in the low-joule
(low-energy) version of all food categories, including beverages covered
by Food Category 14.1.4 (where identified), and in the whole food category,
for which the version was not identified. Individual body weights
were used in the calculations.
2) The second assumed the above was true, except for beverages covered by
Food Category 14.1.4, for which it was assumed that cyclamates were
added to all these beverages.
3) The third assumed typical use levels for cyclamates in Australia for the
low-joule versions of all food categories and the proposed GSFA use levels
for low-joule beverages covered by Food Category 14.1.4.
Dietary exposures were presented for all models for the baseline (i.e. no cyclamates
in beverages covered by Food Category 14.1.4) and maximum use
levels of 250, 500, 750 and 1000 mg/kg, as well as for a level of 350 mg/kg,
which is the current permitted level of use in Australia and New Zealand for
this category of beverages. The same food consumption data derived from
individual records from the 1995 Australian National Nutrition Survey were
used for estimating dietary exposures to cyclamates for all the models. For
the whole population aged 2 years and over who were consumers of beverages
covered by Food Category 14.1.4, mean consumption amounts ranged from
375 to 560 g/day, and 90th-percentile amounts ranged from 625 to 1040 g/
day. For children aged 2–6 years who were consumers of beverages covered
by Food Category 14.1.4, mean consumption amounts ranged from 230 to
420 g/day, and 90th-percentile amounts ranged from 320 to 900 g/day.
For the first model, for the whole population aged 2 years and over, mean
and 90th-percentile dietary exposures for consumers of products containing
cyclamates were below the ADI of 0–11 mg/kg bw (25–30% of the ADI for
mean consumers, 55–75% of the ADI for 90th-percentile consumers). For
children aged 2–6 years, mean dietary exposures to cyclamates for consumers
were also below the ADI (60–65% of the ADI). However, in this age group,
dietary exposures to cyclamates exceeded the ADI at the 90th percentile of
exposure at baseline and for all optional levels of cyclamates in beverages
covered by Food Category 14.1.4 (120–150% of the ADI). The higher dietary
exposures expressed per kilogram body weight for young children compared
with adults are to be expected, owing to relatively higher levels of consumption
of food per kilogram body weight; additionally, members of this age
group are relatively high consumers of fine bakery wares, juices and juice
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