Anaerobic Infections
Anaerobic Infections
Anaerobic Infections
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Tetanospasmin<br />
• Potent exotoxin, tetanospasmin (TS), is<br />
produced by C. tetani at the site of the wound<br />
• The toxin is internalized at the neuromuscular<br />
junction into the alpha motor neuron<br />
• TS then travels by retrograde axonal flow to to<br />
the cell body and diffuses out into the synapses<br />
and extracellular spaces of the CNS<br />
• Its major effect is to inhibit transmitter release<br />
from the presynaptic inhibitory neuron
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