Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
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Aspergillus sp.<br />
• Usually OPPORTUNISTIC infection, only<br />
occasionally PATHOGENIC<br />
• When PATHOGENIC, Aspergillosis<br />
– usually involves one organ: lungs, paranasal<br />
sinuses, external ear<br />
– <strong>CNS</strong> involvement rare as pathogenic infection<br />
but has been described as isolated<br />
granulomas in immunocompetent patients<br />
ei<strong>the</strong>r from environmental exposure (farmers)<br />
or after brain surgery<br />
Aspergillus sp.<br />
• When OPPORTUNISTIC,<br />
– Usually spreads from lung to brain via<br />
bloodstream but rarely may extend directly<br />
from paranasal sinuses or orbit<br />
– Extent t <strong>of</strong> <strong>CNS</strong> involvement in<br />
OPPORTUNISTIC infection ranges<br />
considerably from one study to ano<strong>the</strong>r (60%)<br />
– Patient risk: steroid use, neutropenia<br />
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