Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Ameba<br />
• Entamoeba histolytica<br />
– Spread to brain via hematogenous route from liver or lung<br />
– <strong>CNS</strong> involvement rare; meningoencephalitis in 1-2% <strong>of</strong><br />
fatal cases<br />
– Trophozoites 15-25 microns, cysts are up to 25 microns<br />
<strong>and</strong> spherical with 4-8 nuclei<br />
• Naegleria fowleria<br />
– Free living waterborne ameba affecting previously health<br />
children <strong>and</strong> young adults esp. in summer <strong>and</strong> autumn<br />
months; swimming in warm lakes or pools<br />
– Protozoa enter <strong>CNS</strong> through nasal mucosa <strong>and</strong> cribriform<br />
plate<br />
– Trophozoities 10-20 microns; cysts never seen in tissues<br />
due to rapidly fatal course in patient<br />
• Granulomatous amebic encephalitis<br />
(Acanthamoeba/Balamuthia)<br />
- Trophozoites 15-45 microns; cysts 15-20 microns with<br />
wrinkled double wall<br />
Ameba<br />
27
Change language