Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
Fungal and Parasitic Infections of the CNS - Inova Health System
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<strong>CNS</strong> Protozoal infections:<br />
Toxoplasma gondii<br />
• Worldwide; occurs following ingestion <strong>of</strong> oocysts<br />
shed in cat feces<br />
• Depending on geographic region, 3-50% <strong>of</strong><br />
population has antibodies<br />
• PATHOGENIC infection frequent: infectious<br />
mononucleosis-like illness, febrile illness with<br />
maculopapular rash<br />
• <strong>CNS</strong> involvement almost always an<br />
OPPORTUNISTIC infection; <strong>CNS</strong> involvement<br />
major complication <strong>of</strong> disseminated disease in<br />
AIDS <strong>and</strong> congenital cases<br />
<strong>CNS</strong> Protozoal infections: Toxoplasma gondii<br />
<strong>CNS</strong> disease takes <strong>the</strong> form <strong>of</strong> abscesses, with acute necrotizing,<br />
organizing, <strong>and</strong> chronic forms recognized<br />
<strong>CNS</strong> Protozoal infections: Congenital toxoplasmosis<br />
Destructive, cavitating<br />
process in immature fetal<br />
brain, with minimal<br />
inflammatory reaction &<br />
dystrophic mineralization:<br />
organisms difficult to<br />
demonstrate at this stage<br />
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