OPENING SESSION - ismrm

Monday AM
CLINICAL INTENSIVE COURSE
SWI Metalheads: Imaging Brain Iron
Room K2 11:00 -13:00 Organizers & Moderators: Stefan Sunaert and Mark A. Van Buchem
EDUCATIONAL OBJECTIVES
Upon completion of this course participants should be able to:
Describe methods and underlying principles for obtaining and analyzing susceptibility weighted images;
Explain current thinking regarding iron metabolism and deposition within the brain; and
Describe several diseases of iron deposition within the brain and the application of susceptibility weighted imaging to diagnosis
and study of these processes.
11:00 SWI Basics, Applications and Pitfalls
Jürgen R. Reichenbach, Ph.D.
11:40 Pathophysiology of Brain Iron
John F. Schenck, M.D., Ph.D.
12:20 Diseases of Iron Deposition
Mark A. Van Buchem, M.D., Ph.D.
13:00 Adjournment
MRI of Neural Plasticity
Room A1 11:00-13:00 Moderators: Jeffrey Joseph Neil and John G. Sled
11:00 Introduction
Jeffrey Joseph Neil
11:12 4. Training Induced Volume Changes Seen by Structural MRI Correlate with Neuronal Process
Remodelling
Jason Philip Lerch 1 , Adelaide P. Yiu 2 , Alonso Martinez-Cabal 2 , Tanyar Pekar 2 , Veronique D. Bohbot 3 ,
Paul Frankland 2 , R Mark Henkelman 1 , Sheena A. Josselyn 2 , John G. Sled 1
1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2 Program in Neuroscience and Mental Health, Hospital
for Sick Children, Toronto, Ontario, Canada; 3 Douglas, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
We correlated training induced volume changes seen by high-resolution mouse MRI with four cellular markers to test whether (1) alterations in neuron
numbers/sizes; (2) alterations in astrocyte numbers/sizes; (3) increased neurogenesis/survival of new neurons; or (4) remodelling of neuronal processes best
explain the MRI results. We detected a significant positive correlation between GAP-43 and structure volume, but found no correlation between MR volume
and any other cellular measure. We can thus conclude that, among the hypotheses tested, the largest explanatory factor for learning induced MRI detectable
volume changes is the remodelling of neuronal processes.
11:24 5. Do Congenitally Blind People Have a Stria of Gennari? First in Vivo Insights on a Subcortical Level
Robert Trampel 1 , Derek Veit Ott 1 , Robert Turner 1
1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
The primary visual cortex V1 is characterized by an easily identifiable anatomical landmark: the heavily myelinated stria of Gennari. Using T 1 , T 2 , T 2 * or
phase contrast, high resolution MRI studies can routinely identify the stria of Gennari in vivo. However, the development and function of the Gennari stripe
is unclear. MRI at 7 Tesla with isotropic 0.5 mm voxels was used to scan the occipital brain of sighted and congenitally blind subjects. The stria of Gennari
was reliably detected in both sighted and blind subjects, showing that this anatomical feature is not a developmental result of visual input, and it does not
degenerate in the absence of visual input.