OPENING SESSION - ismrm

Monday AM
we have obtained PCr images from phantoms (50 mM) and the lower extremity of human volunteers in 10 minutes on a 9.4T whole-body scanner. With an
in-plane spatial resolution of 7.5mm x 7.5mm, the PCr images show anatomic details with an adequate signal to noise ratio (SNR=14).
12:12 29. 1H MR Spectroscopy of the Human Prostate Using an Adiabatic Sequence with a SAR Optimized
Endorectal RF Coil
Catalina Arteaga 1 , Uulke A. van der Heide 1 , Marco van Vulpen 1 , Peter R. Luijten 2 , Dennis W.J. Klomp 2
1 Radiotherapy, UMC Utrecht, Utrecht, Netherlands; 2 Radiology, UMC Utrecht, Utrecht, Netherlands
Prostate 1H MRSI at 7T with fully adiabatic sequences like full-LASER allows polyamine detection. In addition, choline and creatine levels can also be
depicted in prostate cancer patients even with hormone therapy. We showed that fully adiabatic sequences can overcome the B1 inhomogeneities compared
to semi-adiabatic sequences.
12:24 30. High Resolution GABA Mapping in Vivo Using a Slice Selective MEGA-MRSI Sequence at 3 Tesla
He Zhu 1,2 , Ronald Ouwerkerk 1,3 , Richard A.E. Edden 1,2 , Peter B. Barker 1,2
1 Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States;
2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3 The National
Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, United States
A spin echo based MEGA-MRSI sequence was developed to acquire MEGA-edited spectra of γ-aminobutyric acid (GABA) in an entire slice with excellent
sensitivity. Co-editing of lipid and NAA signals was greatly suppressed by a dualband pre-saturation sequence and integrated outer volume suppression
(OVS) pulses. Experiments in normal volunteers were performed at 3 Tesla using a 32-channel head coil. High signal-to-noise ratio spectra and metabolic
images of GABA (and glutamate) were acquired from 4.5 cm3 voxels in a scan time of 17 minutes.
12:36 31. Qualitative Detection of Ceramide and Other Metabolites in Brain Tumor by Localized Correlated
Spectroscopy
Rajakumar Nagarajan 1 , Whitney B. Pope 1 , Noriko Salamon 1 , Linda M. Liau 2 , Timothy Cloughesy 3 , M
Albert Thomas 1
1 Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2 Neurosurgery, University of
California Los Angeles; 3 Neurooncology, University of California Los Angeles
Magnetic resonance spectroscopy (MRS) provides metabolic information about brain tumors complementary to what can be obtained from anatomic images.
In contrast to other metabolism-based imaging techniques, MRS yields multiparametric data, does not require ionizing radiation, and can be performed in
conjunction with magnetic resonance imaging studies. Magnetic resonance spectral patterns have been shown to be distinct for different tumor types and
grades. Two-dimensional (2D) localized correlated spectroscopy (L-COSY) in patients with high and low grade gliomas provides better dispersion of several
metabolites such as N-acetylaspartate (NAA), creatine (Cr) choline (Cho), ceramide (Cer), phosphoethanolamine (PE), glutamine/glutamate (Glx), lactate
(Lac), myo-inositol (mI), taurine (Tau), etc. which has been a major difficulty in 1D MRS.
12:48 32. Increased Signal-To-Noise in High Field Localized Spectroscopy of the Temporal Lobe Using New
Deformable High-Dielectric Materials
Andrew Webb 1 , Hermien Kan 1 , Maarten Versluis 1 , Nadine Smith 1
1 Radiology, Leiden University Medical Center, Leiden, Netherlands
The intrinsic B1 non-uniformities from standard volume resonators at high field are particularly problematic for localized spectroscopy of areas such as the
temporal lobe, where low signal-to-noise results from a reduced B1 field. Using a recently developed high dielectric constant material placed around the
head, increases in signal-to-noise of ~ 200% can be achieved in such problem areas without reducing the sensitivity in other areas of the brain.
MR Sensors & Reporters
Room A5 11:00-13:00 Moderators: Eric T. Ahrens and Assaf Gilad
11:00 33. Enzymatic Triggered Release of Imaging Probe from Paramagnetic Liposomes
Sara Figueiredo 1 , Enzo Terreno 2 , Joao Nuno Moreira 3 , Carlos F.G.C. Geraldes 1 , Silvio Aime 2
1 Dep. of Biochemistry and Technology and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal;
2 Department of Chemistry and Molecular Imaging Center, University of Torino, Torino, Italy; 3 Lab. of Pharmaceutical Technology
and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
The design of imaging probes reporting about a given enzymatic activity is an important task in Molecular Imaging investigations.
The aim of this work was to prepare paramagnetic liposomes encapsulating the clinically approved Gd-HPDO3A complex and able to release the imaging
probe in the presence of a specific enzyme upregulated in a given disease.
To do this, an amphiphilic lipopeptide acting as substrate for MMP (Matrix Metallo Proteinases) was prepared and incorporated in liposomes.
It has been reporetd that in the presence of MMP like collagenase, the liposomes release its content, thus determining the detection of a T1 contrast
enhancement.