RASBURICASE: Single fixed dose or package insert dose?
RASBURICASE: Single fixed dose or package insert dose?
RASBURICASE: Single fixed dose or package insert dose?
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<strong>RASBURICASE</strong><br />
Pharmacokinetics<br />
Half life: 18 hours<br />
Volume of distribution in pediatric pts.<br />
110 – 127 mL/kg<br />
AUC and Cmax increase linearly in the<br />
dosage range of 0.15 – 0.2 mg/kg<br />
No accumulation of drug when given<br />
daily f<strong>or</strong> 5 days<br />
Package Insert. Rasburicase.<br />
Sanofi-Synthelabo.2004
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