Thesis-Final 03 June 2011 pdf - Jacobs University

Aims and objectives
As described chlorogenic acids are an integral and important part of the human diet.
This class of compounds is ubiquitous in dietary material and responsible for a large
variety of known health benefits and possibly for a series of health benefits not
established to date. The project aims at making a first step in addressing the
importance of chlorogenic acids in the human diet. An attempt has been made to
synthesise as many as possible regioisomeric mono-acyl, di-acyl and poly-acyl
chlorogenic acids of the homo di-acyl type and the hetero di-acyl type.
Ideally one or more complete series of mono-acyl and di-acyl chlorogenic acids aimed
to be synthesised.
The compounds are required for the following purpose:
1. As reference standards for future analysis of chlorogenic acid containing food
material.
2. As reference standards for verifying LC-MS n based hierarchical scheme for
the identification of chlorogenic acids
3. To have as many as reference material available for systematic biological
testing and screening of dietary chlorogenic acids in the future.
4. As reference standards to be able to study reactivity of chlorogenic acids in
food processing in the future.
Furthermore with the analytical reference material in hand, the compounds should be
mapped against naturally occurring chlorogenic acids using LC-MS methods.
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