Statement of Ronald B. Herberman, MD Chairman of Board ...

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in human fibroblasts but not in lymphocytes. Int Arch Occup Environ Health May;81(6):755-67. 4. Yadav & Sharma. Increased frequency of micronucleated exfoliated cells among humans exposed in viva to mobile telephone radiations. Mutat Res. 2008 Feb 29;650(2):175-80. Epub 2007 Nov 29. 5. Mirriam Webster's Collegiate Dictionary, Tenth Edition. Merriam-Webstef, Inc. Springfield, MA. U.S.A 1993. 6. Baan et al. Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncology Published online June 22,2011 DOI:lO.l016/S1470-2045(11)70147-4. 7. Devra Davis, Disconnect, The Truth About Cellphone Radiation, What the Industry Has Done to Hide It, and How to Protect Your Family, Dutton, New York, NY USA, p, 200. 8. Johansen et al. Cellular Telephones and Cancer-a Nationwide Cohort Study in Denmark. Journal of the National Cancer Institute, Vol. 93, No. 3, February 7, 2001. 9. Schuz et al. Cellular Telephone Use and Cancer Risk Update of a Nationwide Danish Cohort. Journal of the National Cancer Institute, Vol. 98, No. 23, December 6,2006. 10. Schiiz et al. Risks for Central N~NOUS System Diseases among Mobile Phone Subscribers: A Danish Retrospective Cohort Study. PLoS ONE, 1 February 2009, Volume 4, Issue 2. 11, Morgan LL. Estimating the risk of brain tumors from cellphone use: Published case-control studies. Pathophysiology. 2009 Aug; 16(2-3): 137-47. Epub 2009 Apr 7.
2 Cell phones and glioma risk: a review of the evidence 3 Courtney Corle Milan Makale - Santosh Kesarl 4 Il:cc~*eJ 27 S.p:einner.20.0l,\;ccp:ej: I July ? Ill j :2 Spri4igr.r Sctenc~~Ru~icess \Icdla. !.LC 2C I Introdaction Recently cell phones have become the target of much controversy because they are increasingly betng viewed as potential carcinogenic agents with a causal role m brain tumor development The overall inc~dennee of malignant brain tumors in the UtutedStates from 1992 to 2007 declined slightly from 6 8 to 6.2 per 100.000, while the Incidence in chlldren has riren sliglitly over the pesr three decadec [I, 21 According to the Central Brain Tumor Registry (CBTRUS) [3] m 199S1heincideuceofboth benign and malignant brain tumors was 13.4 per 100,000 and in 2004 it was 18 2 per 100.000. The causc of the clear increase m benign tumor tncidence 1s unknown, but there is concern that cell phones can trigger biological effects and that several decades of cell phone usein an individual may signifiuntly increase the nsk of a malignant brain tumor The potenual public heaith problem 1s sizeable as the most colnmon malignant brain tumors are hlghly lethal and cell phoneuse in the U.S. alone haq e5calated dramat~cally, with approximately 70 mlllion new cell phone rub~cnptions between 2006 and 2010, and 250 million subscriptions overall rn 2007 [4,51. The concem relating to cell phone use and braincancer is underscored by the fact that teens andchildren are beginning to use cell phones at younger ages C61. Moreover, greater than 4 of 5 childredteens 12 years and older sleep wlth a cell phone next to them, often underthe pillow [71 Children Counney Corle and Mihn Makek are co-flrrr auihor$ and young adultsaremore suscepnble to the harmful effects of carcinogen~c agents such as rad~ation [a]. Therefore, a shift in inc~dence of brain tumors lnyoungernge groups may emerge as therr exposure to cell phones reaches long-term status and attains the 10-yearor greater mark. Arecent study revealed that children exposed to 1,800 MHi cell phone eiectromagnetic fields (EMF) can experience signlfioantl$ higher exposures to corr~cal regions, hippocampus, hypothalainus and the eye than adults, and that this difference can be greater thaR one order of lnagnrthde [61. The most feared brain tumors in adults and chrldren are the gliomas, whlch include the astrocytomns and nligodendrogliomas These tumors are graded on a progressive scale of mal1gnancy-and4ornor-bhxd~fl, and astrocytomas that have progressed to the Grade IV Wotld Health Organization (WHO) clarsification level ale also !mown as glioblastomas [91. Ghoblostomas are common bra~n tumors and most frequently manse de novo os pnmary cancer$. The gliomas as a whole compnse approximately 33% of all brain tumors and 7945 of malignant brain tumors 131.. Cum is not vp~cal and the therapy of even low grade ghoms can be challenging The glioblastomas are highly lethal and despite &&6 treatment efforts patients are dead at a medlan of 14 months after diagnosis [lo]. Five ycar swvlval is dismal, less than 5% This review will focus specifically oh glioma nsk from ell phone use, and will begin with a brief overvmw af the state of the relevant cell phone-brain tumor r~sk likwature. The two significant, comprehendve databases conceming cell phone use and brain cancer risk are tlie often cited Hardell (Sweden) and the multicenter Eworrenn Intemhone A2 C. Corle . M. Makale . S. Knari (a) studies [ll, 121. These two groups each ~nclude multiple 63 A3 DepertmenL oFNeurorcreoces, UC S m &ego, hboies UCSD A4 C~ncer Center, 3855 Healrh Sciences Dnve, MC studles, and they eompnse the major focus of the cutient 0819. LaJolia, 64 ~5 CA 92093-0819, USA review. Olioma risk data denved from Hardell and inter- 65 A6 e-mall sksan@ucsd edu phone, as well as h some smaller studies, is pmitioned 66 Imnd. Lnrgc 11060 UlWdl. 21.74051 hp 13 o LE n rv~~sfr MIC& d cr d DISK 9 Springer
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