Statement of Ronald B. Herberman, MD Chairman of Board ...

complement epidetniological studies so that data f~om
these two sources can be cross-referenced m reveal
important assouattons. For example short term epidemiological
data that tncludes intense exposures might be
related to in vitro and in viva experiments that screen for
the cell and tisue effects of short term, Intense exposures
Moreover, studies involving humans, head phantoms, cell
cultures and antmal models may be integrated to provide a
mechanistic understanding of events associated w~th ipsilateral
and convalateral exposures and nsks, as this is
currently poorly understood and problemdtic.
Published repons suggest that mammalian brain tissue
may be sensittve to cell phone levels of EMF and exhibit
measurable changes in structutE md function [5, 17-21 1.
For example there u evidence whlch sllows that certain
enLymus and DNA can be directly damaged by lowintensity
EMFs, although mote canfirtnatory work needs to
be done and the precise mechanism(s) of damage has to be
elucidated [5, 17, IS, 211. The work of Volkow el al. [lq
w~th human subjects shows that cell phone use at lower
than typtcal energy levels can cause psil lateral Increases in
bran glucose metaboltsm This acute physiolagicai finding
Indicates chat biological effects can be caused by exposure
to cell photle EMF, and it is reasonable to conclude that
further tn vltro and in vivo studies to elucidate potential
mecltanistns of lrrological damage are warranted [211
Conclusions
Edwards BK (ads) SEER Cancer Sta~ixtics Review, 1975-2002,
National Cancer Instirure. Bcrhesda. MD, htrp:/!scc~.caacer.gov!
cudi975_20M/, based on November 2W6 S m darn submission,
posted m the SEER Web site, 2007
2. Pwes J (2010) One canclusion emerges from Interphone smdy:
conrmversy will continue, I Natl Cancer lmt 102(13):928-931
3. (2010) CBTRUS statistical repon: primary brain .and centrzl
nervous system tumors diagnosed in the United States in
2004-2006. Central Brain Tomor Registry of the United States.
Hirisdale
4. Bonnin JM, Rubinstein LI 11989) A8rrubTastomasa pathologicat
study of 23 tomors, with a post-operative foliaw-op in 13
patients. Neurosurgery 25(1):6-13
5. Khurvila VG, Teo C, Kundi M. Hardell L, Cilrkrg M (2009)
Cell phones and bnin tumors! u review including the long-term
epidemiologic dam. Surg New1 72(3):205-214 (discussion
214215)
6. Christ A, Gosselin MC, Christopoulou M, Kuhn S, Kuster N
(2010) Age.dependeut tissue-specific exposure of ceil phonc
usen. Phys Med Bioi 55(7):L767-1783
7. Lenhae A, Ling R, Catnpbcli SW, Furcell K [ZOIO, Apiil) Teens
and mobile phones. A project of the Pew Ramirrch Center and the
University of Michipn. Aveilable at http:i/www.pewintcrneior&'
Repom!201O~ems-;md-M(1biie~Phones.~spx
8. Knamtsch P. SpixC, lung I, BiettoorM (2008) Childhoodl=ukcmia
In the vicinity of nuclear power planrs in Germany. Dlsch Arztchl
lnt 105:725-732
9. Gladson Ch Pr;lyson RA, Li'u WM (2010) TheparhobioTogy of
~lioma tumors. Annu Rev Pathgl Mech Dia 533-50
10. Dierrich J. Diamond EL. Kes& S S2OlOl . . Olioma stem ccn sienaling:
therapeutic opportunities and challenges. Expee Rev
Allticancer nler 10(5):709-722
1 I . Hnrdell L, Mild KH. Cariberg M. Haliqtiisr A (2004) Cellnlarnnd
cordless telephone use and the a~sociition with brain tumorr in
different age gmups. Arch Environ Health 59(3): 132-137
12, Cardis E (2010) Bnin turnour risk in relation to mobile telephrme
use: resulk of the INTERPHONE incemarinnal case-control
study. lnt J Epidemiol 39(3):675-695
Despire results pointing to an association in one 13. Curdis E, Dellour I, cl (20081 Distributio,I of RF
direction or another, it is clear thS there is no definite rnrrgy emitted by mobile phoncs in anatomical structures of tho
answer to rhe question of whether cell phone use is asso- brain. Phys Med Biol53(1 1):2771-2783
ciated increased brain risk. ~ ~ ~ * i ~ 14. h Schuz ~ l(20091 ~ ~ Lost ~ in d lilternlity: i ~ interpreting ~ 'preferred side OF
the hezd during mabile phone use and risk of brain rumour"
the inconsisttncies in !he epiderniologicai studies, a few of ,,Sociarions, Publie Meiilrh 31(61:664467
the human studies do suggest tlrr associatiin between cell IS. Hubor R. Trcyer V. Schudorel- I ct a1 (2005) Exposure to pulse-
phone UTE- and brain tumors for a 10 year or greater
~nduction period andlor a h~gh nomber of cwmulattve call
hours. However, given the tncooclusive nature of even the
long terrn data, the best eourse of action is to putsue further
stttcttes and to execute thebe acco~ding to a standardtzed
design. Moreover, in view OF the confltoring epidemiological
data, same researchers including the present authors
ruggesr that cell phone use certainly conrinue, but that
users mtght wish to consider using headsets if feasible to
reduce EMF exposun, and that heavy cell phone use in
chtldren and young teens be avoided ~ iat all possiblc [44].
References
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Bloli45[1) 1-12
Springer
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