Some Biological Activities of Vine Stilbens and New ... - Oiv2010.ge

The search for the fundamentals of the phenomenon of the “French paradox” was followed by
the intense study of the content of red wines on an international scale. Numerous experiments
have demonstrated the leading role of biologically active phenol substances in the formation
of the curative and nutritive value of red wines. Identification of stilbens and particularly
resveratrol, which is their monomer representative, and their determination in red and pink
wines made of different vine species in a range of countries is associated with these studies.
(Waterhouse,1993; Roggero, Archier, 1994; .Lamuela-Raventos et al.,1995; Romero-
Perez et al.,1996; Lamuela-Rawentos, Waterhouse, 1993; Lamikarna, et al.,1996).The
further studies, besides resveratrol, identified its derivatives: piceids, dimmers: ε-viniferin and
δ-viniferin; trimer α-viniferin, etc. as well as other stilbens. (Ribeiro de Lima et al.,1999;
Guebailia et al., 2006). Out of resveratrol isomers, it is red wines with the higher content of
trans-resveratrol if compared to cis-resveratrol. At the same time, trans-resveratrol is
biologically more active than cis-resveratrol. The established diversified biological activities
of stilbens greatly make for the positive effect of red wines against cardiovascular, cancerous,
thrombotic and other diseases( Blond et al., 1995; Klatsky et al.,1997; Yang et al., 1997;
Szmitko, Verma, 2005; Balestrieri et al., 2008).
.
We started to study stilbens in 1991-1994, and individually isolated and identified transresveratrol,
ε-viniferin and two tetramers of resveratrol from 1-year-old Rkatsiteli (Vitis
vinifera L.) vine shoot (Bezhuashvili et al., 1991; Bezhuashvili et al., 1997; Bezhuashvili,
1994).
Trans-resveratrol
ε-viniferin
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