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studies were able to provide a detailed insight into the dynamics of blood flow<br />
immediately after EP and ECT treatments. The distinct phases in blood flow changes<br />
observed in tumours indicate that there are probably several different mechanisms<br />
involved in modification of microcirculatory pattern. The short-lived changes<br />
immedi-ately after application of EP pulses most probably reflect the direct effect of<br />
pulses on smooth muscle cells in tumour vasculature as indicated by disappearance<br />
of the vasomotion component from the LDF signals after EP application. In later<br />
stages other effects such as killing of the endothelial cells in vascular walls either by<br />
pulses alone or by ECT might be involved with a potential impact on the treatment<br />
outcome as a whole.<br />
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