Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Methods: Meta-Dose-Response Analysis<br />
Mono-<strong>the</strong>rapy LDL-C % change dose-response:<br />
Stat<strong>in</strong>s and Non-stat<strong>in</strong>s: gemcabene, ezetimibe<br />
E<br />
drug<br />
=<br />
Dose<br />
Dose<br />
n<br />
n<br />
+<br />
⋅<br />
E<br />
ED<br />
max<br />
50<br />
n<br />
Interaction term added to describe comb<strong>in</strong>ations<br />
LDL % change = E0<br />
+ E<br />
stat<strong>in</strong><br />
+ E<br />
non −stat<strong>in</strong><br />
+ γ ⋅ E<br />
stat<strong>in</strong><br />
⋅ E<br />
non −<br />
stat<strong>in</strong><br />
+ η + ε<br />
Weighted (by variance) non-l<strong>in</strong>ear mixed effects (study level random<br />
effect) regression to estimate model parameters.<br />
slide 28<br />
30 May 2008, ARCS<br />
© Pharsight Corporation All Rights Reserved
Change language