Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
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…. And What Can Be Done About It?<br />
Model-Based <strong>Drug</strong> Development (MBDD)<br />
● Ra<strong>the</strong>r than fill<strong>in</strong>g <strong>in</strong> gaps <strong>in</strong> knowledge, M&S is now<br />
be<strong>in</strong>g used to better design future studies and drug<br />
development programs:<br />
• Optimize cl<strong>in</strong>ical drug development focus on<br />
establish<strong>in</strong>g exposure-response relationships to allow<br />
correct choice <strong>of</strong> dose(s)<br />
• Establish <strong>the</strong> use <strong>of</strong> drug-disease models and<br />
advanced pharmacometric concepts <strong>in</strong> early drug<br />
development<br />
• Promote <strong>the</strong> use <strong>of</strong> <strong>in</strong>novative cl<strong>in</strong>ical designs early <strong>in</strong><br />
cl<strong>in</strong>ical development to establish pro<strong>of</strong> <strong>of</strong> concept<br />
and exposure-response relationships<br />
slide 5<br />
30 May 2008, ARCS<br />
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