Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
Communicating the Value of Pharmacodynamic Modelling in Drug ...
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Gemcabene: The next step: Effectively Communicate<br />
Key <strong>Drug</strong> Attributes to Decision- Makers<br />
Estimate predictive distribution by re-sampl<strong>in</strong>g from model<br />
parameter covariance matrix (simulate large multidimensional data<br />
set)<br />
Perform simulations and display <strong>in</strong> <strong>Drug</strong> Model Explorer® (DMX®)<br />
● A visualization and communication tool to explore M&S results and<br />
facilitate quantitative decision-mak<strong>in</strong>g<br />
● Allows exploration <strong>of</strong> key drug attributes and <strong>the</strong>ir respective uncerta<strong>in</strong>ties<br />
by <strong>the</strong> team<br />
<strong>Drug</strong><br />
Model<strong>in</strong>g-<br />
Build<strong>in</strong>g<br />
<strong>Drug</strong><br />
Attribute<br />
Expectations<br />
Non-Technical<br />
User<br />
Interface<br />
Attribute<br />
Simulations<br />
DMX Users<br />
slide 34<br />
30 May 2008, ARCS<br />
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