Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
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44 th Annual Meeting & ToxExpo TM<br />
<strong>Program</strong><br />
New Orleans<br />
M a r c h 6 – 1 0 , 2 0 0 5
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong><br />
New Orleans<br />
Louisiana<br />
44 th Annual<br />
Meeting &<br />
ToxExpo TM<br />
March 6–10, 2005<br />
SOT President<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> invites you to join us in<br />
New Orleans, Louisiana from March 6–10, 2005<br />
for our 44 th Annual Meeting. An outstanding<br />
slate <strong>of</strong> symposia, workshops, roundtables, and<br />
continuing education courses that cover a wide<br />
range <strong>of</strong> topics have been selected by the <strong>Program</strong><br />
and Continuing Education Committees.<br />
New Orleans <strong>of</strong>fers the opportunity to combine<br />
cutting-edge science and comradery in a city<br />
known for its rich culture, hospitality, and<br />
fabulous food. We can't wait to see you there.<br />
All text and graphics are © by the<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> unless noted.<br />
All New Orleans photos are courtesy<br />
<strong>of</strong> the New Orleans Metropolitan<br />
Convention & Visitors Bureau, Inc.<br />
Linda S. Birnbaum<br />
SOT President
Contents<br />
<strong>Program</strong> Overview ....................................Inside Front Cover<br />
Events Calendar ........................................................................2<br />
44 th Annual Meeting & ToxExpo <br />
March 6–10, 2005<br />
Sessions Index<br />
Scientific Sessions Index ........................................................33<br />
New Orleans Restaurants ........................................................7<br />
Ernest N. Morial Convention Center Map ............................8<br />
Hilton Riverside Hotel Map ..................................................10<br />
Sheraton Hotel Map ............................................................... 11<br />
Continuing Education<br />
Continuing Education Courses .............................................39<br />
New Orleans Hotel Accommodations .................................12<br />
ToxExpo Exhibit Hall Floorplan .......................................13<br />
2005 Exhibitors ........................................................................14<br />
<strong>Program</strong><br />
<strong>Program</strong> Description ..............................................................47<br />
ToxExpo and Informational Sessions ...............................16<br />
General Information ...............................................................21<br />
Award Winners<br />
2005 Award Winners ...............................................................27<br />
2004 SOT Fellowship Winners Making<br />
Presentations ..........................................................................31<br />
Social Functions<br />
Social Events ............................................................................32<br />
Sponsorship<br />
SOT References<br />
Author Index .........................................................................225<br />
SOT Affiliates for 2005 .........................................................245<br />
2004–2005 Council .................................................................246<br />
Officers and Councilors .......................................................248<br />
Past Presidents .......................................................................248<br />
Headquarters Staff ...............................................................249<br />
Elected Committees ..............................................................250<br />
Appointed Committees ........................................................250<br />
Officers—Specialty Sections ................................................253<br />
Officers—Regional Chapters ...............................................254<br />
SOT Award Descriptions .....................................................255<br />
<strong>Toxicology</strong> Specialists ...........................................................264<br />
Diamond and Platinum Sponsors ...........Inside Front Cover<br />
Gold, Silver, and Contributor<br />
Sponsors .....................................................Inside Back Cover<br />
New Orleans,<br />
Louisiana
EVENTS CALENDAR<br />
Annual Meeting Events Calendar<br />
Saturday March 5, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
8:00 AM to 1:30 PM<br />
Council Meeting<br />
Hilton Riverside<br />
Jasperwood<br />
2:00 PM to 5:00 PM<br />
Committee Chair Orientation<br />
Ernest N. Morial Convention Center<br />
211<br />
4:00 PM to 7:00 PM<br />
Message Center/Lodging<br />
Information Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
4:00 PM to 7:00 PM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
4:00 PM to 7:00 PM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
5:00 PM to 5:45 PM<br />
Continuing Education Walk-Through<br />
Ernest N. Morial Convention Center<br />
206<br />
5:00 PM to 7:00 PM<br />
CRAD Seminar<br />
(First Come, First Served)<br />
Sheraton Hotel<br />
Napoleon D1<br />
5:30 PM to 8:30 PM<br />
Education Fellowship Interviews<br />
Sheraton Hotel<br />
Edgewood B<br />
5:30 PM to 6:00 PM<br />
Undergraduate Education <strong>Program</strong><br />
Orientation for SOT Hosts, Peer<br />
Mentors and Advisors<br />
Sheraton Hotel<br />
Nottoway<br />
6:15 PM to 9:00 PM<br />
Undergraduate Education <strong>Program</strong><br />
for Minority Students—Lecture &<br />
Reception<br />
Sheraton Hotel<br />
Oak Alley<br />
Sunday March 6, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
7:00 AM to 8:30 PM<br />
Coat Check<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 7:45 AM<br />
Continuing Education<br />
Sunrise Mini-Course<br />
(Ticket Required)<br />
Ernest N. Morial Convention Center<br />
R01<br />
7:00 AM to 5:00 PM<br />
Message Center/Lodging<br />
Information Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 8:00 PM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 5:00 PM<br />
SOT Office<br />
Ernest N. Morial Convention Center<br />
205<br />
7:00 AM to 5:30 PM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
7:30 AM to 2:30 PM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
8:00 AM to 5:00 PM<br />
Childcare Services<br />
(Contingent on Enrollment)<br />
Hilton Riverside<br />
Windsor<br />
8:00 AM to 10:00 AM<br />
CRAD Committee Meeting I<br />
Ernest N. Morial Convention Center<br />
216<br />
8:00 AM to 4:30 PM<br />
Guest Hospitality Center<br />
Hilton Riverside<br />
Compass<br />
8:00 AM to 5:00 PM<br />
ToxExpo Set Up<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
8:00 AM to 5:00 PM<br />
Undergraduate Education<br />
<strong>Program</strong> Session<br />
Ernest N. Morial Convention Center<br />
213<br />
8:15 AM to 12:00 NOON<br />
Continuing Education Courses<br />
(Ticket Required)<br />
Ernest N. Morial Convention Center<br />
(See Signage for Room Locations)<br />
10:00 AM to 3:30 PM<br />
CRAD Office<br />
(Registration Only)<br />
Ernest N. Morial Convention Center<br />
217<br />
11:00 AM to 12:00 NOON<br />
IUTOX Enhancement <strong>of</strong> the<br />
Appreciation and Image <strong>of</strong><br />
<strong>Toxicology</strong> Task Force Meeting<br />
Hilton Riverside<br />
Newberry<br />
11:45 AM to 1:15 PM<br />
CE Luncheon for Speakers, Committee<br />
and Student Volunteers<br />
(By Invitation Only)<br />
Ernest N. Morial Convention Center<br />
226<br />
12:00 NOON to 1:00 PM<br />
IUTOX Education and Career<br />
Development Commission Meeting<br />
Hilton Riverside<br />
Ascot<br />
12:00 NOON to 3:00 PM<br />
Toxicological Sciences Associate<br />
Editors Meeting<br />
Hilton Riverside<br />
Jasperwood<br />
1:00 PM to 5:00 PM<br />
IUTOX Executive Committee<br />
Meeting I<br />
Hilton Riverside<br />
Newberry<br />
1:15 PM to 5:00 PM<br />
Continuing Education Courses<br />
(Ticket Required)<br />
Ernest N. Morial Convention Center<br />
(See Signage for Room Locations)<br />
4:30 PM to 5:15 PM<br />
Awards Recipients Photographed<br />
Ernest N. Morial Convention Center<br />
220<br />
5:15 PM to 6:30 PM<br />
Award Presentation<br />
(All Attendees Welcome)<br />
Ernest N. Morial Convention Center<br />
220<br />
6:30 PM to 7:30 PM<br />
Welcoming Reception<br />
(All Attendees Welcome)<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom<br />
6:45 PM to 7:15 PM<br />
Student Advisory Committee<br />
Meeting I<br />
Hilton Riverside<br />
Durham<br />
7:00 PM to 8:00 PM<br />
25–Year Member (or More) Reception<br />
(By Invitation Only)<br />
Ernest N. Morial Convention Center<br />
215<br />
7:30 PM to 9:30 PM<br />
Association <strong>of</strong> Scientists <strong>of</strong> Indian<br />
Origin in America<br />
Hilton Riverside<br />
Rosedown<br />
7:30 PM to 9:00 PM<br />
International Neurotoxicology<br />
Association Business Meeting<br />
Hilton Riverside<br />
Melrose<br />
7:30 PM to 8:30 PM<br />
Student/Post-Doctoral Fellow Mixer<br />
(All Students and Post-Docs are Invited<br />
to Attend)<br />
(Ticket Required)<br />
Hilton Riverside<br />
Grand Ballroom A<br />
8:00 PM to 10:30 PM<br />
Arizona Night<br />
Hilton Riverside<br />
Oak Alley<br />
8:00 PM to 10:00 PM<br />
IUTOX Executive Committee Dinner<br />
Brennan’s Restaurant<br />
8:00 PM to 10:00 PM<br />
LRRI Reception for Current & Former<br />
Employees<br />
Embassy Suites<br />
Atrium<br />
2<br />
SOT's 44 th Annual Meeting
Annual Meeting Events Calendar (Continued)<br />
Monday March 7, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
6:30 AM to 8:00 AM<br />
Regulatory Affairs and<br />
Legislative Assistance<br />
Committee Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
6:45 AM to 8:00 AM<br />
Metals Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
212<br />
7:00 AM to 8:00 AM<br />
American Board <strong>of</strong> Veterinary<br />
<strong>Toxicology</strong>: Executive Board Meeting<br />
Hilton Riverside<br />
Durham<br />
7:00 AM to 9:15 AM<br />
Carcinogenesis Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
223<br />
7:00 AM to 8:30 PM<br />
Coat Check<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 8:30 AM<br />
Continuing Education Committee<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
225<br />
7:00 AM to 8:00 AM<br />
Ethical, Legal, and Social Issues<br />
Specialty Section Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
215<br />
7:00 AM to 8:30 AM<br />
Mechanisms Specialty Section Officers’<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
227<br />
7:00 AM to 5:00 PM<br />
Message Center/Lodging<br />
Information Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 5:00 PM<br />
MPI—CardIon Breakfast Breifing<br />
Hilton Riverside<br />
Grand Salon 13<br />
7:00 AM to 9:00 AM<br />
Neurotoxicology Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
228<br />
7:00 AM to 8:30 AM<br />
Past Presidents Breakfast<br />
Ernest N. Morial Convention Center<br />
211<br />
7:00 AM to 5:00 PM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 8:30 AM<br />
Regulatory & Safety Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
229<br />
7:00 AM to 5:00 PM<br />
SOT Office<br />
Ernest N. Morial Convention Center<br />
205<br />
7:00 AM to 5:00 PM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
7:30 AM to 2:30 PM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:30 AM to 7:00 PM<br />
CRAD Services<br />
Ernest N. Morial Convention Center<br />
217<br />
7:30 AM to 8:30 AM<br />
Membership Committee Meeting<br />
Ernest N. Morial Convention Center<br />
213<br />
7:30 AM to 8:30 AM<br />
<strong>Program</strong> Committee Walk-Through<br />
Ernest N. Morial Convention Center<br />
206<br />
7:30 AM to 3:00 PM<br />
Undergraduate Education <strong>Program</strong><br />
for Minority Students<br />
Ernest N. Morial Convention Center<br />
214<br />
8:00 AM to 5:00 PM<br />
Childcare Services<br />
(Contingent on Enrollment)<br />
Hilton Riverside<br />
Windsor<br />
8:00 AM to 4:30 PM<br />
Guest Hospitality Center<br />
Hilton Riverside<br />
Compass<br />
8:30 AM to 9:15 AM<br />
Plenary Lecture: Science, Policy, and<br />
Regulation at the White House Office <strong>of</strong><br />
Information and Regulatory Affairs<br />
Dr. John D. Graham<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom<br />
9:30 AM to 10:30 AM<br />
Complimentary C<strong>of</strong>fee in the Exhibit<br />
Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 2:30 PM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 11:00 AM<br />
IUTOX Certification and Registration<br />
Task Force Meeting<br />
Hilton Riverside<br />
Ascot<br />
9:30 AM to 11:30 AM<br />
Poster Session for Visiting Students<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 12:30 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 12:00 NOON<br />
Scientific Sessions<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
Ernest N. Morial Convention Center<br />
9:30 AM to 4:30 PM<br />
ToxExpo Exhibits Open<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
11:45 AM to 1:30 PM<br />
Immunotoxicology Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
211<br />
12:15 PM to 1:15 PM<br />
MRC Lecture: Novel Uncompetitive<br />
Antagonists Protect Neurons from<br />
Excitotoxic, Oxidative, and<br />
Nitrosative Stress<br />
Dr. Stuart A. Lipton<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom B<br />
12:15 PM to 1:15 PM<br />
Roundtable Session:<br />
Electrocardiography Safety Evaluation<br />
Studies—New Techniques and<br />
Approaches<br />
Ernest N. Morial Convention Center<br />
R01<br />
12:30 PM to 5:30 PM<br />
IUTOX Executive Committee<br />
Meeting II<br />
Hilton Riverside<br />
Newberry<br />
1:00 PM to 3:00 PM<br />
Undergraduate Education <strong>Program</strong><br />
Focus Groups<br />
Ernest N. Morial Convention Center<br />
216<br />
1:30 PM to 2:30 PM<br />
VIP ToxExpo Exhibit Hall<br />
Walk-Through<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
1:30 PM to 4:30 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
1:30 PM to 4:30 PM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
2:30 PM to 3:30 PM<br />
Complimentary Refreshments in Exhibit<br />
Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
4:30 PM to 6:00 PM<br />
American Board <strong>of</strong> <strong>Toxicology</strong> Mixer/<br />
Open Meeting<br />
Hilton Riverside<br />
Melrose<br />
4:30 PM to 6:00 PM<br />
CRAD Seminar: Consulting as a<br />
Career Choice<br />
Ernest N. Morial Convention Center<br />
207<br />
4:30 PM to 6:00 PM<br />
Scientific Sunset Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
4:30 PM to 6:00 PM<br />
Specialty Section Presidents’ and<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
223<br />
5:00 PM to 6:30 PM<br />
Harmonization: Legislation/Diet/<br />
Rodent Model<br />
Hilton Riverside<br />
Belle Chase<br />
5:00 PM to 7:00 PM<br />
Joint Reception <strong>of</strong> the Mountain West<br />
and Southern California Regional<br />
Chapters<br />
Hilton Riverside<br />
Grand Salon 9<br />
5:00 PM to 7:00 PM<br />
Standard for Exchange <strong>of</strong> Non-Clinical<br />
Data: An Industry FDA Partnership<br />
Hilton Riverside<br />
Elmwood<br />
5:00 PM to 7:00 PM<br />
Taylor & Francis Reception<br />
Hilton Riverside<br />
Grand Salon 15<br />
5:30 PM to 7:30 PM<br />
Roundtable <strong>of</strong> <strong>Toxicology</strong> Consultants<br />
Meeting<br />
Hilton Riverside<br />
Oak Alley<br />
6:00 PM to 8:00 PM<br />
Central States Regional Chapter<br />
Reception<br />
Hilton Riverside<br />
Grand Salon 19<br />
6:00 PM to 7:30 PM<br />
Ethical, Legal, and Social Issues<br />
Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
215<br />
6:00 PM to 7:30 PM<br />
Hispanic Organization Reception<br />
Ernest N. Morial Convention Center<br />
226<br />
6:00 PM to 7:30 PM<br />
Immunotoxicology Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
225<br />
6:00 PM to 7:30 PM<br />
Mechanisms Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
231<br />
6:00 PM to 8:00 PM<br />
Northeast Regional Chapter Reception<br />
Hilton Riverside<br />
Grand Salon 12<br />
6:00 PM to 7:30 PM<br />
Occupational and Public Health<br />
Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
227<br />
6:00 PM to 7:30 PM<br />
Risk Assessment Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
229<br />
6:00 PM to 8:00 PM<br />
St. John’s University 3rd Annual<br />
<strong>Toxicology</strong> Alumni Dinner<br />
Hilton Riverside<br />
Grand Salon 13<br />
6:00 PM to 7:30 PM<br />
Toxicologic and Exploratory Pathology<br />
Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
228<br />
6:00 PM to 6:30 PM<br />
Undergraduate <strong>Toxicology</strong> Teaching<br />
Forum<br />
Ernest N. Morial Convention Center<br />
R02<br />
6:00 PM to 8:00 PM<br />
University <strong>of</strong> North Carolina <strong>Toxicology</strong><br />
Students and Alumni<br />
Riverside Hilton<br />
Grand Salon 16<br />
6:30 PM to 8:30 PM<br />
Inhalation <strong>Toxicology</strong> Specialty Section<br />
2005 Editorial Board Meeting<br />
Hilton Riverside<br />
Grand Salon 6<br />
7:30 PM to 10:00 PM<br />
Oxford University Press Dinner<br />
Brennan’s Restaurant<br />
9:00 PM to 11:00 PM<br />
MSU Center for Integrative <strong>Toxicology</strong><br />
Alumni and Friends Reception<br />
Hilton Riverside<br />
Grand Salon 18<br />
EVENTS CALENDAR<br />
up-to-date information at www.toxicology.org 3
EVENTS CALENDAR<br />
Annual Meeting Events Calendar (Continued)<br />
Tuesday March 8, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
7:00 AM to 8:00 PM<br />
Coat Check<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 8:00 AM<br />
Cutaneous & Ocular <strong>Toxicology</strong> 2005<br />
Editorial Board Meeting<br />
Hilton Riverside<br />
Oak Alley<br />
7:00 AM to 8:00 AM<br />
Molecular Biology Section<br />
Officers Meeting<br />
Ernest N. Morial Convention Center<br />
228<br />
7:00 AM to 8:00 AM<br />
MPI Fast Systems Breakfast Briefing<br />
on Flow Cytometry and Immunology<br />
Hilton Riverside<br />
Grand Salon 3<br />
7:00 AM to 8:30 AM<br />
Regional Chapter Presidents and<br />
Officers Meeting<br />
Ernest N. Morial Convention Center<br />
225<br />
7:00 AM to 8:30 AM<br />
Reproductive and Development<br />
Specialty Section Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
231<br />
7:00 AM to 7:45 AM<br />
Scientific Sunrise Session<br />
Ernest N. Morial Convention Center<br />
R01<br />
7:00 AM to 5:00 PM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
7:00 AM to 8:30 AM<br />
Student Advisory Committee Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
7:00 AM to 8:15 AM<br />
ULM <strong>Toxicology</strong> Alumni Breakfast<br />
Hilton Riverside<br />
Elmwood<br />
7:00 AM to 8:00 AM<br />
Women in <strong>Toxicology</strong> Section Officers’<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
229<br />
7:15 AM to 8:15 AM<br />
Town Hall Meeting: NIH-Mandated<br />
Public Access to Sponsored Research<br />
Publications: Impact on Toxicological<br />
Sciences<br />
Presiding: Lois Lehman-McKeeman,<br />
Editor <strong>of</strong> Toxicological Sciences and<br />
Richard Peterson, Chair <strong>of</strong> the Board<br />
<strong>of</strong> Publications<br />
Ernest N. Morial Convention Center<br />
R06<br />
7:30 AM to 2:30 PM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:30 AM to 5:30 PM<br />
CRAD Services<br />
Ernest N. Morial Convention Center<br />
217<br />
7:30 AM to 9:00 AM<br />
Food Safety Specialty Section Officers’<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
230<br />
7:30 AM to 8:30 AM<br />
In Vitro Specialty Section Officers’<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
226<br />
8:00 AM to 9:30 AM<br />
Board <strong>of</strong> Publications Meeting<br />
Ernest N. Morial Convention Center<br />
201<br />
8:00 AM to 5:00 PM<br />
Childcare Services<br />
(Contingent on Enrollment)<br />
Hilton Riverside<br />
Windsor<br />
8:00 AM to 9:30 AM<br />
Dermal Specialty Section Officers’<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
227<br />
8:00 AM to 4:30 PM<br />
Guest Hospitality Center<br />
Hilton Riverside<br />
Compass<br />
8:00 AM to 4:00 PM<br />
Message Center/Lodging Information<br />
Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Foyer<br />
8:00 AM to 4:30 PM<br />
Paracelsus Goes to School Teacher<br />
Workshop<br />
Ernest N. Morial Convention Center<br />
213<br />
8:00 AM to 4:00 PM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Foyer<br />
8:00 AM to 4:00 PM<br />
SOT Office<br />
Ernest N. Morial Convention Center<br />
205<br />
8:30 AM to 3:45 PM<br />
Informational Sessions<br />
(Consult the ToxExpo Directory for<br />
Session Times and Descriptions)<br />
Ernest N. Morial Convention Center<br />
215 & 223<br />
8:30 AM to 9:30 AM<br />
IUTOX Communications<br />
Commission Meeting<br />
Hilton Riverside<br />
Ascot<br />
8:30 AM to 11:30 AM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
8:30 AM to 4:30 PM<br />
ToxExpo Exhibits Open<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 10:30 AM<br />
Complimentary C<strong>of</strong>fee in the<br />
Exhibit Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 12:30 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
12:00 NOON to 1:15 PM<br />
Eleventh International Congress<br />
on <strong>Toxicology</strong> Scientific <strong>Program</strong><br />
Committee Meeting<br />
Belle Chase<br />
Hilton Riverside<br />
12:00 NOON to 1:15 PM<br />
In Vitro <strong>Toxicology</strong> Lecture &<br />
Luncheon for Students<br />
(Ticket Required)<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom A<br />
12:00 NOON to 1:00 PM<br />
SOT/EUROTOX Debate<br />
Nanoparticles are a Major Threat to<br />
Human Health<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom B<br />
1:00 PM to 2:00 PM<br />
IUTOX Developing Countries<br />
Committee Meeting<br />
Hilton Riverside<br />
Ascot<br />
1:30 PM to 3:30 PM<br />
Forum on Grantsmanship and Sources<br />
for Research Support<br />
Ernest N. Morial Convention Center<br />
R02<br />
1:30 PM to 4:30 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
1:30 PM to 4:30 PM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
2:30 PM to 3:30 PM<br />
Complimentary Refreshments in<br />
Exhibit Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
4:30 PM to 5:30 PM<br />
An Informal Session for Students with<br />
the Director, NIEHS<br />
Ernest N. Morial Convention Center<br />
214<br />
4:30 PM to 6:00 PM<br />
Scientific Sunset Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
4:30 PM to 6:00 PM<br />
SOT Annual Business Meeting<br />
(SOT Members Only)<br />
Ernest N. Morial Convention Center<br />
207<br />
4:45 PM to 6:00 PM<br />
ToxExpo 2006 Exhibit Space Selection<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
223<br />
5:30 PM to 8:00 PM<br />
Immunotoxicology Specialty Section<br />
Student & Post-Doc Mixer<br />
Mullates Restaurant (across the street<br />
from the Convention Center)<br />
5:30 PM to 6:30 PM<br />
Regional Chapter Contacts for<br />
K–12 Education<br />
Committee Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
6:00 PM to 9:00 PM<br />
American Association <strong>of</strong> Chinese in<br />
<strong>Toxicology</strong><br />
Hilton Riverside<br />
Grand Salon 16<br />
6:00 PM to 7:30 PM<br />
Biological Modeling Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
226<br />
6:00 PM to 7:30 PM<br />
Carcinogenesis Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
228<br />
6:00 PM to 7:30 PM<br />
In Vitro Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
225<br />
6:00 PM to 7:30 PM<br />
Inhalation Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
215<br />
6:00 PM to 7:30 PM<br />
Metals Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
227<br />
6:00 PM to 7:30 PM<br />
Neurotoxicology Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
231<br />
6:00 PM to 8:00 PM<br />
Northern California Regional Chapter<br />
Reception<br />
Hilton Riverside<br />
Grand Salon 18<br />
6:00 PM to 8:00 PM<br />
Pacific Northwest Regional<br />
Chapter Meeting<br />
Hilton Riverside<br />
Grand Salon 6<br />
6:00 PM to 7:30 PM<br />
Regulatory and Safety Evaluation<br />
Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
229<br />
6:30 PM to 8:00 PM<br />
Neurobehavioral Teratology <strong>Society</strong><br />
Social<br />
Hilton Riverside<br />
Grand Salon 12<br />
7:00 PM to 8:30 PM<br />
South Central Regional Chapter<br />
Meeting/Reception<br />
Hilton Riverside<br />
Grand Salon 13<br />
7:30 PM to 10:00 PM<br />
University <strong>of</strong> Rochester Alumni<br />
Reception<br />
Hilton Riverside<br />
Grand Salon 15<br />
4<br />
SOT's 44 th Annual Meeting
Annual Meeting Events Calendar (Continued)<br />
Wednesday March 9, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
6:30 AM to 8:00 AM<br />
Comparative and Veterinary Specialty<br />
Section Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
227<br />
7:00 AM to 8:00 PM<br />
Coat Check<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 8:30 AM<br />
Education Subcommittee for Minority<br />
Initiatives Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
7:00 AM to 8:30 AM<br />
Midwest Regional Chapter Members<br />
Breakfast<br />
Ernest N. Morial Convention Center<br />
226<br />
7:00 AM to 8:00 AM<br />
MPI Research Breakfast Briefing on<br />
Positron Emission Temography (PST)<br />
Hilton Riverside<br />
Grand Salon 3<br />
7:00 AM to 5:00 PM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
7:00 AM to 9:00 AM<br />
Toxicologic and Exploratory Pathology<br />
Specialty Section Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
229<br />
7:00 AM to 8:30 AM<br />
WWW Advisory Committee Meeting<br />
Ernest N. Morial Convention Center<br />
225<br />
7:15 AM to 8:30 AM<br />
Animals in Research Committee<br />
Meeting<br />
Ernest N. Morial Convention Center<br />
211<br />
7:30 AM to 2:30 PM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:30 AM to 9:30 AM<br />
CRAD Committee Meeting<br />
Ernest N. Morial Convention Center<br />
213<br />
7:30 AM to 5:30 PM<br />
CRAD Services<br />
Ernest N. Morial Convention Center<br />
217<br />
8:00 AM to 5:00 PM<br />
Childcare Services<br />
(Contingent on Enrollment)<br />
Hilton Riverside<br />
Windsor<br />
8:00 AM to 4:30 PM<br />
Guest Hospitality Center<br />
Hilton Riverside<br />
Steering Room<br />
8:00 AM to 4:00 PM<br />
Message Center/Lodging<br />
Information Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
8:00 AM to 4:00 PM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
8:00 AM to 4:00 PM<br />
SOT Office<br />
Ernest N. Morial Convention Center<br />
205<br />
8:30 AM to 3:45 PM<br />
Informational Sessions<br />
(Consult the ToxExpo Directory for<br />
Session Times and Descriptions)<br />
Ernest N. Morial Convention Center<br />
215 & 223<br />
8:30 AM to 11:30 AM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Descriptions for Room<br />
Locations)<br />
8:30 AM to 4:30 PM<br />
ToxExpo Exhibits Open<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 10:30 AM<br />
Complimentary C<strong>of</strong>fee in the<br />
Exhibit Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
9:30 AM to 12:30 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
11:30 AM to 1:00 PM<br />
Education Subcommittee for K–12<br />
Education Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
11:30 AM to 1:30 PM<br />
Finance Committee Meeting<br />
Ernest N. Morial Convention Center<br />
225<br />
11:45 AM to 1:15 PM<br />
Immunotoxicology 2005 Editorial<br />
Board Meeting<br />
Hilton Riverside<br />
Belle Chase<br />
12:00 NOON to 1:00 PM<br />
Issues Session: Reorganization <strong>of</strong><br />
the NIH Grant Review Process and<br />
its Potential Impact on <strong>Toxicology</strong><br />
Research and Training<br />
Ernest N. Morial Convention Center<br />
208<br />
12:00 PM to 1:00 PM<br />
Roundtable Session: Conducting a<br />
Comprehensive Toxicological and Safety<br />
Evaluation <strong>of</strong> Nanomaterials: Current<br />
and Challenges and Data Needs<br />
Ernest N. Morial Convention Center<br />
R08<br />
12:00 NOON to 1:00 PM<br />
Special Workshop: A Conversation<br />
with the Directors<br />
Ernest N. Morial Convention Center<br />
R01<br />
1:30 PM to 2:00 PM<br />
Education Committee Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
1:30 PM to 3:00 PM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
1:30 PM to 4:30 PM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
2:00 PM to 4:00 PM<br />
Exhibit Liaison Committee Meeting<br />
Ernest N. Morial Convention Center<br />
228<br />
2:30 PM to 3:30 PM<br />
Complimentary Refreshments in<br />
Exhibit Hall<br />
Ernest N. Morial Convention Center<br />
Exhibit Hall A<br />
4:30 PM to 6:00 PM<br />
Scientific Sunset Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
4:45 PM to 5:30 PM<br />
SOT Council Meeting with Students/<br />
Post-Doctoral Fellows<br />
Ernest N. Morial Convention Center<br />
213<br />
5:00 PM to 6:00 PM<br />
Drug Discovery Specialty Section<br />
Officers’ Meeting<br />
Ernest N. Morial Convention Center<br />
231<br />
5:00 PM to 6:30 PM<br />
<strong>Toxicology</strong> Mechanisms and Methods<br />
2005 Editorial Board Meeting<br />
Hilton Riverside<br />
Oak Alley<br />
5:00 PM to 6:30 PM<br />
University <strong>of</strong> Wisconsin Molecular<br />
and Environmental <strong>Toxicology</strong> Center<br />
Reception<br />
Hilton Riverside<br />
Rosedown<br />
5:30 PM to 6:00 PM<br />
Council Meeting with Student<br />
Advisory Committee<br />
Ernest N. Morial Convention Center<br />
213<br />
6:00 PM to 7:30 PM<br />
Comparative and Veterinary Specialty<br />
Section Reception<br />
Ernest N. Morial Convention Center<br />
228<br />
6:00 PM to 7:30 PM<br />
Dermal Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
227<br />
6:00 PM to 7:30 PM<br />
Drug Discovery Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
231<br />
6:00 PM to 7:30 PM<br />
Food Safety Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
226<br />
6:00 PM to 7:30 PM<br />
Molecular Biology Specialty Section<br />
Reception<br />
Ernest N. Morial Convention Center<br />
225<br />
6:00 PM to 7:30 PM<br />
Reproductive and Developmental<br />
Specialty Section Reception<br />
Ernest N. Morial Convention Center<br />
229<br />
6:00 PM to 7:30 PM<br />
Women in <strong>Toxicology</strong> Specialty Section<br />
Reception and Panel Discussion<br />
Ernest N. Morial Convention Center<br />
215<br />
7:00 PM to 8:30 PM<br />
President’s Reception<br />
(By Invitation Only)<br />
Hilton Riverside<br />
Versailles Ballroom<br />
EVENTS CALENDAR<br />
up-to-date information at www.toxicology.org 5
EVENTS CALENDAR<br />
Annual Meeting Events Calendar (Continued)<br />
Thursday March 10, 2005<br />
Events are listed alphabetically<br />
by the event start time.<br />
7:00 AM to 1:00 PM<br />
Coat Check<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:00 AM to 11:30 AM<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center<br />
202<br />
7:00 AM to 9:00 AM<br />
<strong>Toxicology</strong> Education Foundation<br />
Board Meeting<br />
Hilton Riverside<br />
Trafalgar Room<br />
7:30 AM to 11:30 AM<br />
Concession Stands<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
7:30 AM to 9:30 AM<br />
CRAD Committee Meeting II<br />
Ernest N. Morial Convention Center<br />
225<br />
7:30 AM to 12:00 NOON<br />
CRAD Services<br />
(Message Center Only)<br />
Ernest N. Morial Convention Center<br />
218<br />
7:30 AM to 8:30 AM<br />
<strong>Program</strong> Committee Meeting<br />
Ernest N. Morial Convention Center<br />
216<br />
8:00 AM to 12:00 NOON<br />
Childcare Services<br />
(Contingent on Enrollment)<br />
Hilton Riverside<br />
Windsor<br />
8:00 AM to 11:30 AM<br />
Guest Hospitality Center<br />
Hilton Riverside<br />
Steering Room<br />
8:00 AM to 11:30 AM<br />
Message Center/Lodging<br />
Information Booth<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
8:00 AM to 11:30 AM<br />
Registration<br />
Ernest N. Morial Convention Center<br />
Hall A Lobby<br />
8:00 AM to 11:30 AM<br />
SOT Office<br />
Ernest N. Morial Convention Center<br />
205<br />
8:30 AM to 11:30 AM<br />
Poster Sessions<br />
Ernest N. Morial Convention Center<br />
La Louisiane Ballroom B<br />
8:30 AM to 11:30 AM<br />
Scientific Sessions<br />
Ernest N. Morial Convention Center<br />
(See <strong>Program</strong> Description for Room<br />
Locations)<br />
SATELLITE MEETING<br />
12:30 PM to 5:30 PM<br />
NAS Public Workshop:<br />
Public Databases: Sharing <strong>of</strong><br />
Toxicogenomic Data<br />
Hilton Riverside<br />
Belle Chase<br />
(See Full Details on page 224)<br />
See You Next Year in . . .<br />
Deadline for SOT 2006<br />
Annual Meeting Session<br />
Proposals is April 30, 2005.<br />
Visit the SOT Web site<br />
for Session Proposal and<br />
meeting information.<br />
www.toxicology.org<br />
SOT 45 th Annual Meeting<br />
March 5–9, 2006<br />
6<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
New Orleans Restaurants<br />
New Orleans City Restaurants Located within 4 Blocks <strong>of</strong> the Convention Center:<br />
Under $10<br />
Deanie’s<br />
Annunciation Street<br />
(504) 561–9251<br />
Riverwalk Food Court<br />
(504) 522–1555<br />
Red Eye Grill<br />
852 S. Peters Street<br />
(504) 593–9393<br />
Taqueria Corona<br />
857 Fulton Street<br />
(504) 524–9805<br />
True Brew Café<br />
200 Julia Street<br />
(504) 524–8441<br />
Ernst Café<br />
600 S. Peters Street<br />
(504) 524–8544<br />
Sweet Olive Café<br />
610 Tchoupitoulas Street<br />
(504) 299–8188<br />
Embassy Suites<br />
315 Julia Street<br />
(504) 525–1993<br />
$10–$20<br />
Rock-n-Sake<br />
823 Fulton Street<br />
(504) 821–7253<br />
Rio Mar<br />
800 S. Peter Street<br />
(504) 525–3474<br />
Lucy’s Restaurant<br />
701 Tchoupitoulas Street<br />
(504) 523–8995<br />
The Praline Connection<br />
907 S. Peters Street<br />
(504) 523–3973<br />
Le Cote Brassiere<br />
700 Tchoupitoulas Street<br />
(504) 613–2350<br />
Tchop-n-Joes<br />
870 Tchoupitoulas Street<br />
(504) 581–2858<br />
The Atrium—Holiday Inn<br />
Convention Center Boulevard<br />
(504) 524–1881<br />
Above $20<br />
Emeril’s<br />
800 Tchoupitoulas Street<br />
(504) 528–9393<br />
Café Adelaide—Loews Hotel<br />
300 Poydras Street<br />
(504) 595–3305<br />
Wine L<strong>of</strong>t<br />
752 Tchoupitoulas Street<br />
(504) 561–0116<br />
Tommy’s Cuisine<br />
746 Tchoupitoulas Street<br />
(504) 581–1103<br />
RESTAURANT INFO<br />
Mulate’s Cajun Restaurant<br />
201 Julia Street<br />
(504) 522–1492<br />
For a full listing <strong>of</strong> New Orleans restaurants see the<br />
Annual Meeting Web site at www.toxicology.org.<br />
up-to-date information at www.toxicology.org 7
Ernest N. Morial<br />
44 th Annual Meeting<br />
and ToxExpo<br />
MAPS<br />
Exhibit Hall<br />
Entrance<br />
Registration<br />
Business Center<br />
Restaurant<br />
River<br />
Concessions<br />
Concessions<br />
First Aid<br />
Message Center Tours<br />
Tour Bus Loading and Departure<br />
E<br />
S<br />
W<br />
La Louisiane<br />
Ballroom<br />
Lower<br />
Level<br />
N<br />
8<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Convention Center Map<br />
MAPS<br />
Elevator<br />
Restrooms<br />
Restrooms<br />
Elevator<br />
Upper<br />
Level<br />
up-to-date information at www.toxicology.org 9
44 th Annual Meeting<br />
and ToxExpo<br />
Hilton Riverside Hotel Map<br />
To Riverside Building<br />
First<br />
Floor<br />
Main Entrance<br />
MAPS<br />
Elevators to 2 & 3<br />
Floors and to Parking<br />
Garage Level 5<br />
Jazz<br />
French<br />
Garden<br />
Room<br />
River<br />
Second<br />
Floor<br />
Elevators to 1 & 3<br />
Floors and to Parking<br />
Garage Level 5<br />
Eglinton<br />
Winton Chequers<br />
Cambridge<br />
Prince <strong>of</strong><br />
Wales<br />
Marlborough<br />
River<br />
N<br />
W<br />
E<br />
ATRIUM<br />
Loading Dock<br />
S<br />
Trafalgar<br />
Norwich<br />
Business<br />
Center<br />
To Guest Rooms<br />
Pelican<br />
Bridge<br />
Steering<br />
Standard<br />
Compass<br />
Port<br />
River<br />
Fourth<br />
Floor<br />
Elevators to 1 & 2<br />
Floors and to Parking<br />
Garage Level 5<br />
Jefferson<br />
Ballroom<br />
Fountain<br />
Room<br />
Warwick<br />
Durham<br />
Newberry<br />
Oak<br />
Valley<br />
Elmwood<br />
Ascot<br />
Jean<br />
Lafitte's<br />
Cove<br />
Windsor<br />
Jasperwood<br />
Magnolia<br />
River<br />
Riverside<br />
Building<br />
(Second Floor)<br />
Napoleon<br />
Ballroom<br />
Versailles<br />
Ballroom<br />
Belle<br />
Chasse<br />
To Riverside Building<br />
Melrose<br />
Rosedown<br />
10<br />
SOT's 44 th Annual Meeting
Sheraton Hotel Map<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Third<br />
Floor<br />
River<br />
MAPS<br />
S<br />
E<br />
W<br />
N<br />
Fourth<br />
Floor<br />
River<br />
up-to-date information at www.toxicology.org 11
44 th Annual Meeting<br />
and ToxExpo<br />
New Orleans Hotel Accommodations<br />
1. Doubletree Hotel<br />
300 Canal Street<br />
New Orleans, LA 70130<br />
Phone: (504) 581–1300<br />
Fax: (504) 522–4100<br />
4 Blocks from Convention Center<br />
2. Embassy Suites<br />
315 Julia Street<br />
New Orleans, LA 70130<br />
Phone: (504) 525–1993<br />
Fax: (504) 525–3437<br />
1 Block from Convention Center<br />
3. Hampton Inn & Suites<br />
1201 Convention Center Blvd.<br />
New Orleans, LA 70130<br />
Phone: (504) 566–9990<br />
Fax: (504) 566–9997<br />
1 Block from Convention Center<br />
4. Hilton Garden Inn<br />
1001 South Peters Street<br />
New Orleans, LA 70130<br />
Phone: (504) 525–0044<br />
Fax: (504) 525–0035<br />
1 Block from Convention Center<br />
5. Hilton Riverside<br />
2 Poydras Street<br />
New Orleans, LA 70130<br />
Phone: (504) 561–0500<br />
Fax: (504) 568–1721<br />
2 Blocks from Convention Center<br />
6. Holiday Inn Select<br />
881 Convention Center Blvd.<br />
New Orleans, LA 70130<br />
Phone: (504) 524–1881<br />
Fax: (504) 528–1005<br />
1 Block from Convention Center<br />
7. Loews New Orleans<br />
300 Poydras Street<br />
New Orleans, LA 70130<br />
Phone: (504) 595–3300<br />
Fax: (504) 595–3310<br />
8 Blocks from Convention Center<br />
8. Sheraton New Orleans<br />
500 Canal Street<br />
New Orleans, LA 70130<br />
Phone: (504) 525–2500<br />
Fax: (504) 595–5552<br />
10 Blocks from Convention Center<br />
9. W New Orleans<br />
333 Poydras Street<br />
New Orleans, LA 70130<br />
Phone: (504) 525–9444<br />
Fax: (504) 581–7179<br />
10 Blocks from Convention Center<br />
HOTEL INFO<br />
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12<br />
SOT's 44 th Annual Meeting
Itinerary<br />
Planner<br />
Computer<br />
Stations<br />
Tours<br />
44 th Annual Meeting<br />
and ToxExpo<br />
ToxExpo in the Exhibit Hall<br />
ToxExpo<br />
Concessions<br />
Restrooms<br />
Posters<br />
Posters<br />
Computer<br />
Stations<br />
Entrance<br />
Restrooms/Concessions<br />
Registration<br />
Show Office<br />
Security<br />
Convention Center Blvd<br />
Computer<br />
Stations<br />
First Aid<br />
La Louisiane<br />
Ballroom<br />
up-to-date information at www.toxicology.org 13
ToxExpo<br />
2005 Exhibitors<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Alphabetical Listing<br />
(As <strong>of</strong> January 1, 2005)<br />
Please visit ToxExpo.com or the ToxExpo TM Directory<br />
for product/service descriptions, a map <strong>of</strong> booth locations,<br />
and other information.<br />
Company Name ............................................................................Booth Number<br />
AAALAC International .....................................................................................210<br />
ACGIH .................................................................................................................855<br />
ADInstruments .................................................................................................1030<br />
Affymetrix .........................................................................................................1223<br />
Agency for Toxic Substances and Disease Registry ....................................1150<br />
Agilent Technologies .........................................................................................360<br />
Agilent Technologies .........................................................................................361<br />
Alabama Research & Development .................................................................446<br />
Allentown Caging Equipment Co. Inc. ..........................................................524<br />
Alter Analytical Labs .........................................................................................237<br />
Althea Technologies .........................................................................................1327<br />
ALZET® Osmotic Pumps .................................................................................707<br />
American Association for Laboratory Animal Science (AALAS) ...............329<br />
American Chemistry Council (ACC) .............................................................. 111<br />
Amgen, Inc. ........................................................................................................358<br />
Analytical Development Corporation ............................................................940<br />
Ani Lytics, Inc. .................................................................................................1231<br />
Anilab, Inc. .........................................................................................................307<br />
Animal Identification and Marking System, Inc. (AIMS) ............................831<br />
Applied Biosystems .........................................................................................1137<br />
Applied Preclinical Services .............................................................................323<br />
AppTec Laboratory Services ...........................................................................1318<br />
Arcturus ...............................................................................................................250<br />
BAS Evansville ...................................................................................................830<br />
Battelle HHS ........................................................................................................443<br />
BBL Sciences ......................................................................................................1227<br />
BD Biosciences ..................................................................................................1153<br />
Bio Medic Data Systems Inc. ...........................................................................406<br />
Bioagri Pharma ...................................................................................................212<br />
BioDynamics/KWS ...........................................................................................856<br />
Biological Test Center ........................................................................................944<br />
Biologics Consulting Group, LLC ....................................................................949<br />
BioReliance, invitrogen bioservices .............................................................729<br />
Bio-Serv Inc. .......................................................................................................422<br />
BioStat Consultants Inc. .................................................................................1337<br />
Biotechnics, Inc. ..................................................................................................945<br />
Biotrin International ..........................................................................................244<br />
Brady Corporation .............................................................................................852<br />
Bristol-Myers Squibb Company (BMS) ...........................................................859<br />
Burdock Group .................................................................................................1406<br />
Buxco Research Systems .................................................................................1031<br />
Calvert Laboratories, Inc. .................................................................................941<br />
Cambrex ..............................................................................................................960<br />
Cantox Health Science International .............................................................1329<br />
Carl Zeiss Micro Imaging, Inc. .........................................................................132<br />
Cayman Chemical ..............................................................................................251<br />
CeeTox Inc. .........................................................................................................845<br />
Central <strong>Toxicology</strong> Laboratory—Syngenta (CTL) .......................................1319<br />
CEREP ................................................................................................................1340<br />
CH Technologies (USA) Inc. .............................................................................743<br />
ChanTest, Inc. .....................................................................................................851<br />
Charles River Laboratories Clinical Services ...............................................1007<br />
Charles River Laboratories Pathology Services .............................................807<br />
Charles River Laboratories Preclinical Services ............................................907<br />
Charles River Laboratories Research Models & Services .............................806<br />
ChemRisk ............................................................................................................338<br />
CIIT Centers for Health Research ..................................................................1028<br />
Ciphergen Biosystems, Inc. ............................................................................1322<br />
Company Name ............................................................................Booth Number<br />
CIT ......................................................................................................................1106<br />
CLEA International Inc. ....................................................................................318<br />
Colorado Histo-Prep ........................................................................................1122<br />
Comparative Biosciences ................................................................................1217<br />
CorDynamics ......................................................................................................309<br />
Covance ...............................................................................................................715<br />
Covance Research Products Inc. .....................................................................815<br />
CRI, Inc. ..............................................................................................................136<br />
Data Integrated Scientific Systems (D.I.S.S.) ..................................................827<br />
Data Sciences International ..............................................................................930<br />
DaVinci Biomedical Research Products, Inc. .................................................311<br />
Detroit R & D, Inc. ...........................................................................................1248<br />
DIMS Institute <strong>of</strong> Medical Science, Inc. .........................................................221<br />
Dow Corning Corporation ...............................................................................761<br />
Ellegaard Gottingen Minipigs ........................................................................1130<br />
Elm Hill Breeding Labs, Inc. ............................................................................306<br />
Elsevier Science ..................................................................................................915<br />
Embryotech Laboratories, Inc. ......................................................................1144<br />
Emka Technologies ..........................................................................................1241<br />
Environ International ......................................................................................1330<br />
Environmental Health Perspectives (EHP) ..................................................1051<br />
Enzo Life Sciences, Inc. ...................................................................................1253<br />
EPL, Inc. (Experimental Pathology Labs) .......................................................725<br />
Exponent, Inc. .................................................................................................. 1115<br />
Expression Analysis .........................................................................................1326<br />
Exygen Research ................................................................................................217<br />
Fraunh<strong>of</strong>er ITEM ..............................................................................................1214<br />
Gene Logic, Inc. ...............................................................................................1206<br />
Genedata ............................................................................................................1324<br />
Genospectra, Inc. .............................................................................................1128<br />
Gentronix Limited ..............................................................................................460<br />
GlobalTox ..........................................................................................................1220<br />
Gma Industries, Inc. ..........................................................................................548<br />
Gould Instrument Systems, Inc. ......................................................................850<br />
Gwathmey, Inc. ..................................................................................................312<br />
H & T Corporation ...........................................................................................1430<br />
Hamilton Thorne Biosciences, Inc. ...............................................................1215<br />
Harlan ..................................................................................................................737<br />
HemoGenix LLC ................................................................................................950<br />
Hill Top Research, Inc. ......................................................................................931<br />
Hilltop Lab Animals, Inc. ...............................................................................1022<br />
Human Biologics International (HBI) ...........................................................1307<br />
Humana Press .....................................................................................................308<br />
Huntingdon Life Sciences ...............................................................................1037<br />
Hurley Consulting Associates Ltd. .................................................................351<br />
IBT Reference Laboratory ...............................................................................1323<br />
Icoria, Inc. .........................................................................................................1049<br />
IDEXX Contract Research Services ................................................................1109<br />
IIT Research Institute .........................................................................................429<br />
Illumina ...............................................................................................................225<br />
In Vitro Technologies (IVT) .............................................................................1219<br />
Ina Research Inc. ................................................................................................240<br />
Instech Solomon ...............................................................................................1309<br />
Instem LSS ...........................................................................................................459<br />
Institute for In Vitro Sciences, Inc ..................................................................1230<br />
International Congress <strong>of</strong> <strong>Toxicology</strong>-XI (ICT-XI) .......................................1424<br />
International Life Sciences Institute (ILSI) ...................................................1149<br />
IPS Therapeutique, Inc. ....................................................................................219<br />
ISIS BioComp ......................................................................................................554<br />
ITR Laboratories Canada, Inc. .........................................................................751<br />
IUTOX ................................................................................................................1420<br />
Jai Research Foundation (JRF) ........................................................................ 1110<br />
John Wiley & Sons, Inc. ....................................................................................211<br />
Korea Institute <strong>of</strong> <strong>Toxicology</strong> (KIT) .................................................................325<br />
LAB Pre-Clinical Research International ........................................................424<br />
LAB Products, Inc. ............................................................................................407<br />
LABCAT ..............................................................................................................723<br />
LabCorp ...............................................................................................................213<br />
Leadscope Inc. ...................................................................................................842<br />
14<br />
SOT's 44 th Annual Meeting
2005 Exhibitors (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
ToxExpo<br />
Company Name ............................................................................Booth Number<br />
LHASA Limited ..................................................................................................134<br />
Lomir Biomedical, Inc. .....................................................................................927<br />
Lovelace Respiratory Research Institute (LRRI) ............................................858<br />
Marshall Farms USA, Inc. ..............................................................................1129<br />
MB Research Labs, Inc. .....................................................................................316<br />
MD Biotech ........................................................................................................1040<br />
MDS Pharma Services .......................................................................................337<br />
Med Associates Inc. ...........................................................................................759<br />
Merck Research Laboratories ...........................................................................936<br />
Metabometrix Ltd ..............................................................................................220<br />
MicaGenix ...........................................................................................................247<br />
Midwest BioResearch LLs (MBR) ....................................................................458<br />
Midwest Research Institute (MRI) ...................................................................428<br />
Molecular Light Technology UK (A GenProbe Company) (MLT) ..............317<br />
MPI Research ......................................................................................................415<br />
MultiCase Inc. ..................................................................................................1126<br />
National Institute <strong>of</strong> Environmental Health Science (NIEHS) ..................1050<br />
National Library <strong>of</strong> Medicine .........................................................................1121<br />
National <strong>Toxicology</strong> <strong>Program</strong> (NTP) ............................................................1052<br />
Neuroscience Associates (NSA) .......................................................................331<br />
Northview Biosciences ....................................................................................1228<br />
Notocord Systems ..............................................................................................336<br />
NOTOX B.V. .......................................................................................................330<br />
NovaScreen Biosciences Corp ..........................................................................340<br />
Nucro-Technics Incorporated ...........................................................................822<br />
Oxford University Press ..................................................................................1038<br />
Partek Incorporated ...........................................................................................938<br />
Pathology Data Solutions, Inc. ......................................................................1024<br />
Perry Scientific Inc. ...........................................................................................506<br />
Pfizer Global Research & Development .........................................................844<br />
Pharmalytica Services ......................................................................................1341<br />
Phylonix .............................................................................................................1213<br />
PJD Publications-Research Communications ..............................................1018<br />
Preclinical Research Associates ........................................................................849<br />
Primate Products, Inc. (PPI) ..............................................................................929<br />
Prime Resources Bio-Services Limited ..........................................................1325<br />
Product Safety Labs .........................................................................................1029<br />
Promega Corp ...................................................................................................1242<br />
Purina Mills LabDiet .........................................................................................709<br />
QTest Labs ...........................................................................................................452<br />
Quest Pharmaceutical Services, L.L.C. (QPS) ................................................209<br />
Quintiles, Inc. .....................................................................................................922<br />
RASS (Risk Assessment Summer School) .....................................................1418<br />
RCC Ltd. .............................................................................................................836<br />
ReCathCo, LLC ...................................................................................................206<br />
Research Diets, Inc. ...........................................................................................359<br />
Ricerca Biosciences .............................................................................................550<br />
Roche Applied Science ......................................................................................350<br />
Roche Diagnostics Corporation .......................................................................354<br />
Rosetta Bios<strong>of</strong>tware ...........................................................................................958<br />
RTC, Research <strong>Toxicology</strong> Centre S.p.A. ......................................................1321<br />
RTI International ..............................................................................................1123<br />
Safepharm Laboratories Ltd. .........................................................................1143<br />
San Diego Instruments, Inc. ...........................................................................1107<br />
Saronyx, Inc. .....................................................................................................1306<br />
SCANTOX A/S ................................................................................................1124<br />
Schleicher & Schuell BioScience, Inc. ...........................................................1252<br />
Scientists Center for Animal Welfare (SCAW) ...............................................109<br />
SCIREQ, Inc. (Scientific Respiratory Equipment) .........................................937<br />
Sequani Limited .................................................................................................823<br />
SFBC International .............................................................................................450<br />
Sinclair Research Center, Inc. (SRC) ..............................................................1245<br />
SITEK Research Laboratories ...........................................................................861<br />
SkeleTech, Inc. ....................................................................................................236<br />
Smiths Medical MD, Inc. ..................................................................................923<br />
SNBL USA, LTD. .............................................................................................1015<br />
<strong>Society</strong> <strong>of</strong> Quality Assurance (SQA) ................................................................451<br />
SOT—Animals In Research Booth .................................................................1416<br />
SOT—K–12 Resources Booth ..........................................................................1410<br />
Company Name ............................................................................Booth Number<br />
SOT—Membership Booth ....................................... Across from Exhibit Hall A<br />
SOT—Write to Congress (RALA) ..................................................................1422<br />
Southern Research Institute ..............................................................................416<br />
Springborn Laboratories, Inc. ........................................................................1014<br />
SRI International ................................................................................................508<br />
StemCell Technologies, Inc. .............................................................................310<br />
Stillmeadow Inc. ................................................................................................914<br />
Strategic Applications Inc. ................................................................................847<br />
Suburban Surgical Company ...........................................................................939<br />
Taconic .................................................................................................................425<br />
Tandem Labs .....................................................................................................1436<br />
Taylor & Francis .................................................................................................437<br />
TECHSPACE, INC. .........................................................................................1148<br />
The Jackson Laboratory .....................................................................................161<br />
The Leyden Group ...........................................................................................1328<br />
The <strong>Toxicology</strong> Group, LLC .............................................................................245<br />
Thoren Caging Systems, Inc. ...........................................................................207<br />
Tissue Transformation Technologies (TTT) ....................................................453<br />
TNO ......................................................................................................................824<br />
Tox Monitor/BSR, Inc. ....................................................................................1023<br />
TOXCEL LLC ......................................................................................................837<br />
<strong>Toxicology</strong> Education Foundation (TEF) ......................................................1414<br />
<strong>Toxicology</strong> Regulatory Services (TRS) ..........................................................1224<br />
<strong>Toxicology</strong> Research Laboratory (TRL) ..........................................................353<br />
Toxikon Corporation ..........................................................................................916<br />
TSE Systems GmbH ...........................................................................................442<br />
Vesta Therapeutics ...........................................................................................1152<br />
VisualSonics ........................................................................................................449<br />
Vitrocell Systems ................................................................................................745<br />
Vitron, Inc. ........................................................................................................1331<br />
WIL Research Laboratories, LLC ....................................................................951<br />
Wildlife International Ltd. ............................................................................. 1111<br />
XCELLON—The AEgis Technologies Group Inc. ......................................1036<br />
Xenobiotic Detection Systems ..........................................................................227<br />
XenoTech, LLC ....................................................................................................947<br />
Xybion Medical Systems ...................................................................................839<br />
Admittance to the Exhibit Hall is limited to<br />
attendees with full registration.<br />
Children under the age <strong>of</strong> 15 years <strong>of</strong> age are not allowed<br />
in the Exhibit Hall.<br />
Please ask Show Management permission before taking<br />
pictures in the Exhibit Hall.<br />
up-to-date information at www.toxicology.org 15
ToxExpo<br />
44 th Annual Meeting<br />
and ToxExpo<br />
ToxExpo & Informational Sessions<br />
ToxExpo TM /Exhibits<br />
For many <strong>of</strong> the science pr<strong>of</strong>essionals who attend, the focus <strong>of</strong><br />
the SOT Annual Meeting is the three-day ToxExpo Exhibition.<br />
Here, state-<strong>of</strong>-the-art products and services directly relating to the<br />
advancement <strong>of</strong> research within toxicology and associated areas<br />
are displayed.<br />
ToxExpo TM is open:<br />
Monday, March 7 ........................................ 9:30 AM–4:30 PM<br />
Tuesday, March 8 ......................................... 8:30 AM–4:30 PM<br />
Wednesday, March 9 ................................... 8:30 AM–4:30 PM<br />
At the ToxExpo Exhibition scientists have a first-hand<br />
opportunity to talk with the exhibitors, and to examine and learn<br />
about the products and services on display by more than 220<br />
companies.<br />
Reminder:<br />
The ToxExpo Exhibition is considered to be part <strong>of</strong> the<br />
Annual Meeting scientific sessions. Guests and Children<br />
(under 15 years <strong>of</strong> age) are not allowed in the Exhibit Hall.<br />
The <strong>Society</strong> requires approval <strong>of</strong> all photographic equipment<br />
used in the Exhibit Hall. For information or approval,<br />
contact Libby Jones at (703) 438-3115 ext. 1454 or e-mail:<br />
libby@toxicology.org.<br />
Food Service in Exhibit Hall<br />
Quick food service is available in the Convention Center.<br />
Concession stands will be open from 7:00 AM–2:30 PM each day<br />
Sunday through Thursday. Breakfast and lunch items as well<br />
as c<strong>of</strong>fee, soda, bottled water, and snacks will be available for<br />
purchase. The Atrium Restaurant <strong>of</strong>fers an extensive menu and<br />
is open each day.<br />
Informational Sessions<br />
(All Informational Sessions will be held in Room 215 and 223 at the<br />
Ernest N. Morial Convention Center)<br />
The Rosetta Resolver® System: An<br />
Enterprise Solution for Gene Expression<br />
Analysis and Predictive <strong>Toxicology</strong><br />
Presented by Rosetta Biosciences<br />
Tuesday, March 8<br />
8:30 AM–9:30 AM<br />
Room 223<br />
The Rosetta Resolver® System, an enterprise gene expression<br />
analysis solution, is a cornerstone in drug discovery for routinely<br />
processing and managing data from thousands <strong>of</strong> high-density<br />
microarrays. This presentation will focus on the current challenges<br />
<strong>of</strong> toxicogenomics data analysis in drug development, and<br />
how the use <strong>of</strong> the Resolver system addresses those challenges.<br />
Expression Pr<strong>of</strong>iling with BeadArray<br />
Technology: Identification <strong>of</strong> Genes<br />
Induced by Low Level Oxidative Stress<br />
Presented by Illumina<br />
Tuesday, March 8<br />
9:45 AM–10:45 AM<br />
Room 223<br />
We examined variability in bead-based oligonucleotide microarrays<br />
by evaluation <strong>of</strong> dispersion characteristics among<br />
hybridization and biological replicate samples <strong>of</strong> lymphocyte<br />
RNA. Using a consecutive sampling and coincidence test, we<br />
have identified genes whose expression was significantly altered<br />
by low level exposure to oxidative stress.<br />
16<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
ToxExpo<br />
Exhibits & Informational Sessions (Continued)<br />
Toxicity Testing: What Bone Marrow Can<br />
Tell Us<br />
Presented by StemCell Technologies, Inc.<br />
Tuesday, March 8<br />
9:45 AM–10:45 AM<br />
Room 215<br />
Over the past three decades, a spectrum <strong>of</strong> standardized assays<br />
has been developed to characterize and measure bone marrow<br />
function and assess the multiple cell lineages it contains. In<br />
humans, bone marrow is one <strong>of</strong> the five major organ systems<br />
most sensitive to chronic low-dose chemical toxicants, making it<br />
an important target to assess in toxicity screening. This session<br />
will illustrate the rationale for targeting bone marrow for drug<br />
toxicity screening, assays that are employed and importance <strong>of</strong><br />
using primary human cells in functional cell-based assays.<br />
Searching the NTP Databases<br />
Presented by NIEHS<br />
Tuesday, March 8<br />
11:00 AM–12:00 NOON<br />
Room 215<br />
The National <strong>Toxicology</strong> <strong>Program</strong> (NTP) conducts studies on<br />
potentially toxic agents to determine their impact on human<br />
health. Enhancing public access to these data, this workshop<br />
provides information about what is available within the NTP<br />
databases, using real examples to demonstrate the search<br />
process.<br />
Designing Better Pre-Clinical Studies<br />
Using Gene Expression Analysis<br />
Presented by Gene Logic, Inc.<br />
Tuesday, March 8<br />
11:00 AM–12:00 NOON<br />
Room 223<br />
Understanding the expression pattern <strong>of</strong> a target protein in<br />
various tissues can help you plan your small molecule and<br />
biologics safety studies with more precision by suggesting<br />
additional target tissues and potential areas for concern. In this<br />
presentation, you will hear case studies on how scientists can use<br />
Gene Logic’s web-based ASCENTA System to design better<br />
pre-clinical studies.<br />
Rapid Generation <strong>of</strong> Predictive<br />
Toxicogenomic Analysis<br />
Presented by Gene Logic, Inc.<br />
Tuesday, March 8<br />
12:15 PM–1:15 PM<br />
Room 223<br />
Learn how to facilitate drug candidate selection by characterizing<br />
a compound’s toxicity pr<strong>of</strong>ile using an easy, intuitive toxicogenomic-based<br />
s<strong>of</strong>tware application. Several case studies will be<br />
discussed that demonstrate how these rapidly generated results<br />
can be combined with other data to help make better inform<br />
compound decisions.<br />
Leveraging a Multi-Dimensional<br />
Cardiovascular Assessment During Lead<br />
Optimization<br />
Presented by CorDynamics<br />
Tuesday, March 8<br />
1:30 PM–2:30 PM<br />
Room 215<br />
CorDynamics is a contract research organization focused on<br />
examining the cardiac effects <strong>of</strong> emerging drug candidates. Our<br />
models allow us to optimize these lead candidates early in the<br />
drug development process. Focusing on this critical and dynamic<br />
phase improves the attrition rates <strong>of</strong> compounds selected for<br />
further testing, thereby reducing the overall costs and timelines<br />
associated with your projects.<br />
An Introduction to Microarrays<br />
and GeneChip® Technology for<br />
Toxicogenomics<br />
Presented by Affymetrix<br />
Tuesday, March 8<br />
2:45 PM–3:45 PM<br />
Room 215<br />
The Affymetrix GeneChip® System enables toxicologists to reliably<br />
generate, analyze, and manage large quantities <strong>of</strong> genetic<br />
information for accelerated research and biomarker discovery.<br />
This course is an introduction to GeneChip microarray design,<br />
performance, and analysis for applications in toxicogenomics.<br />
up-to-date information at www.toxicology.org 17
ToxExpo<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Exhibits & Informational Sessions (Continued)<br />
Hemotoxicity Testing <strong>of</strong> Xenobiotics and<br />
New Drugs for all Stages <strong>of</strong> the Drug<br />
Development Pipeline<br />
The HALO Platform—In Vitro<br />
Hemotoxicity Testing for the 21 st Century<br />
Presented by HemoGenix, LLC<br />
Tuesday, March 8<br />
2:45 PM–3:45 PM<br />
Room 223<br />
HALO (Hemotoxicity Assays via Luminescence Output) is a<br />
multifunctional and multiparameter testing platform that can<br />
detect and measure the effects <strong>of</strong> virtually any compound on<br />
up to 14 different proliferating cell populations from 5 species<br />
simultaneously from the blood-forming system. The test system<br />
is rapid, quantitative, highly sensitive and non-subjective with<br />
high-throughput capability and is ideal for all phases <strong>of</strong> drug<br />
development, from screening to monitoring the patient’s lymphohematopoietic<br />
system during clinical trials.<br />
Defining Molecular Mechanisms <strong>of</strong><br />
Toxicity Using Affymetrix GeneChip®<br />
Arrays<br />
Presented by Affymetrix<br />
Introduction to Real-Time PCR<br />
Presented by Applied BioSystems<br />
Wednesday, March 9<br />
11:00 AM–12:00 NOON<br />
Room 223<br />
An introduction to the fundamentals <strong>of</strong> real-time PCR technology<br />
and applications. This session will include; an overview <strong>of</strong> absolute<br />
and relative quantitation methods, chemistry & instrument<br />
options, and assay design considerations.<br />
Advances in Real-Time PCR<br />
Presented by Applied BioSystems<br />
Wednesday, March 9<br />
12:15 PM–1:15 PM<br />
Room 215<br />
An overview <strong>of</strong> recent advances including; Validated TaqMan®<br />
Gene Expression and SNP Assays for quantitation and genotyping<br />
<strong>of</strong> the Cytochromes P450 and other drug metabolizing<br />
enzymes, FAST thermal cycling options, and TaqMan® Assays<br />
for microRNA quantitation.<br />
Wednesday, March 9<br />
8:30 AM–9:30 AM<br />
Room 215<br />
Leaders in the use <strong>of</strong> Affymetrix microarray technologies will<br />
share the techniques and strategies they have used successfully<br />
to apply GeneChip products to their research.<br />
Bioluminescent Methods for ADME/Tox<br />
Presented by Promega Corporation<br />
Wednesday, March 9<br />
11:00 AM–12:00 NOON<br />
Room 215<br />
Bioluminescence <strong>of</strong>fers significant advantages for configuring<br />
sensitive, simple to perform, high through-put assays with<br />
ADME/Tox applications. Bioluminescent systems will be<br />
described that measure the cytotoxicity <strong>of</strong> test compounds, their<br />
capacity to induce apoptosis, their impact on various CYP450<br />
activities and on the multi-drug transporter (MDR1/Pgp).<br />
18<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Exhibits & Informational Sessions (Continued)<br />
ToxExpo<br />
SOT Informational Booths<br />
SOT—Animals in Research<br />
Informational Booth<br />
ToxExpo 1416<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> is committed to research <strong>of</strong> the highest<br />
quality and views the use <strong>of</strong> laboratory animals as necessary<br />
to protect human health and the environment, except where<br />
alternative techniques have been validated. Stop by the Animals<br />
in Research Committee booth for information supporting that<br />
position, including the SOT "Importance <strong>of</strong> Animals in Research"<br />
brochure and SOT position statements. A variety <strong>of</strong> other materials<br />
will be on display.<br />
SOT—K–12 Resources Booth<br />
ToxExpo 1410<br />
Pick up tips for classroom mentors and the SOT career<br />
brochure. Investigate other high quality toxicology and<br />
environmental health sciences materials for teachers and<br />
toxicologists who visit classrooms. Come share with the K–12<br />
Education Subcommittee what YOU are doing in your community.<br />
SOT—Membership Booth<br />
ToxExpo (Across from Exhibit Hall A)<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> (SOT) is the largest association <strong>of</strong><br />
pr<strong>of</strong>essional toxicologists in the world. 5,200 plus members<br />
from all parts <strong>of</strong> the United States and more than 40 other<br />
countries enhance their careers through the benefits <strong>of</strong> SOT<br />
membership. SOT provides the premier venues for toxicology<br />
discourse, including meetings, the <strong>of</strong>ficial (and highly cited)<br />
SOT journal Toxicological Sciences, and ToxExpo TM . Visit the SOT<br />
Membership booth to learn more about all member benefits and<br />
for a guided tour <strong>of</strong> the excellent and diverse resources available<br />
through the SOT Web site. Application for membership is easy at<br />
www.toxicology.org.<br />
SOT—Write to Congress (RALA)<br />
ToxExpo 1422<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>'s Regulatory Affairs and Legislative<br />
Assistance (RALA) Committee is the focus for activities that<br />
aid and support the scientifically related functions <strong>of</strong> regulatory<br />
agencies and judicial bodies. If the regulation <strong>of</strong> chemicals and<br />
the funding <strong>of</strong> research in toxicology concern you, visit the SOT<br />
Write to Congress booth for information and to write to your<br />
Congress person.<br />
up-to-date information at www.toxicology.org 19
ToxExpo<br />
Notes:<br />
44 th Annual Meeting<br />
and ToxExpo<br />
20<br />
SOT's 44 th Annual Meeting
General Information<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Sessions and Special Events will be held at the Ernest N. Morial Convention Center unless otherwise listed.<br />
Registration Fees:<br />
On-Site<br />
SOT Member ................................................................$350<br />
Non-Member .............................................................. $600<br />
SOT Retired Member ..................................................$145<br />
Post-Doctoral SOT Member ......................................$160<br />
Post-Doctoral Non-Member ......................................$240<br />
Graduate Student SOT Member ...............................$140<br />
Graduate Student Non-Member ...............................$200<br />
Student Undergraduate .............................................$140<br />
SOT Affiliate ................................................................ $ 0<br />
Press .............................................................................. $ 0<br />
Guest (Non-Scientist) ........................................................$100<br />
Continuing Education Course Fees:<br />
(per AM or PM course)<br />
(Only Annual Meeting Registrants may enroll in CE Courses)<br />
On-Site<br />
SOT Member/Corp/SOT Affiliate ...........................$150<br />
Retired ...........................................................................$145<br />
Non-Member ...............................................................$250<br />
Post-Doctoral (SOT Member or Non-Member) .....................$125<br />
Graduate or Undergraduate Student<br />
(SOT Member or Non-Member) ............................................................ $ 80<br />
Press .............................................................................. $ 0<br />
Continuing Education Sunrise<br />
Mini-Course Fees: (includes continental<br />
breakfast)<br />
On-Site<br />
SOT Member/Corp Affiliate .....................................$ 95<br />
Post-Doctoral (SOT Member or Non-Member) .....................$ 95<br />
Retired ...........................................................................$ 95<br />
Non-Member ...............................................................$115<br />
Graduate or Undergraduate Student .......................$ 65<br />
Press .....................................................................................................$0 0<br />
The Registration Includes:<br />
• Saturday, March 5 evening session addressing career<br />
strategies (see program description on page 45).<br />
• Awards Presentation, Sunday, March 6 from<br />
5:15 PM–6:30 PM.<br />
• Welcoming Reception, Sunday, March 6 from<br />
6:30 PM–7:30 PM.<br />
• Plenary Lecture, Monday, March 7 from<br />
8:30 AM–9:15 AM.<br />
up-to-date information at www.toxicology.org 21<br />
• All Scientific Sessions (see program descriptions beginning<br />
on page 45) 9:30 AM Monday, March 7 through<br />
11:30 AM Thursday, March 10.<br />
• ToxExpo Exhibit Hall, 9:30 AM Monday, March 7 through<br />
4:30 PM Wednesday, March 9.<br />
Participants are also encouraged to register for the Continuing<br />
Education Courses. These are available during three time intervals<br />
on Sunday, March 6: the sunrise mini-course is from 7:00<br />
AM–7:45 AM; morning courses are 8:15 AM–12:00 NOON; and<br />
afternoon courses are from 1:15 PM–5:00 PM.<br />
Registration Desk<br />
Saturday .................................................................4:00 PM–7:00 PM<br />
Sunday .................................................................. 7:00 AM–8:00 PM<br />
Monday ................................................................. 7:00 AM–5:00 PM<br />
Tuesday ................................................................. 8:00 AM–4:00 PM<br />
Wednesday ........................................................... 8:00 AM–4:00 PM<br />
Thursday ............................................................ 8:00 AM–11:30 AM<br />
Registration Materials<br />
When you arrive at the Ernest N. Morial Convention Center,<br />
please go to the registration area to pick up your registration<br />
materials (you do not need to stand in line). Your 2005 Annual<br />
Meeting registration badge must be presented to obtain the registration<br />
materials (i.e., badge holder, the ToxExpo TM Directory and<br />
other supplementary materials). If you do not yet have a meeting<br />
badge, please go directly to the registration desk.<br />
Receipt <strong>of</strong> the <strong>Program</strong> and The<br />
Toxicologist<br />
1. SOT Members in the U.S. and Canada will receive the printed<br />
<strong>Program</strong> and The Toxicologist on CD ROM (with Itinerary<br />
Planner) prior to the meeting, as will U.S. and Canadian nonmembers<br />
who pre-register by January 10, 2005. There will be<br />
a printed version <strong>of</strong> The Toxicologist available on-site in the<br />
registration area for a fee <strong>of</strong> $20, while supplies last.<br />
2. Non-members in the U.S. who register after January 10 will<br />
receive the <strong>Program</strong> and The Toxicologist on CD ROM (with<br />
Itinerary Planner) at the registration area on-site.<br />
3. The Annual Meeting Itinerary Planner will be available on the<br />
SOT Web site January-March.<br />
4. There will be computer kiosks available in the Exhibit Hall to<br />
search The Toxicologist on CD ROM at the Annual Meeting.<br />
NOTE: Please bring your copy <strong>of</strong> the <strong>Program</strong> with you to the meeting.<br />
GENERAL INFO
44 th Annual Meeting<br />
and ToxExpo<br />
General Information (Continued)<br />
GENERAL INFO<br />
Air Transportation<br />
New Orleans is serviced by the Louis Armstrong New Orleans<br />
International Airport (MSY), which is a 20 minute drive<br />
from the Ernest N. Morial Convention Center and hotel area.<br />
Thirteen carriers <strong>of</strong>fer daily flights. For more information, visit<br />
www.flymsy.com.<br />
SOT has established discounted rates through Delta Airlines for<br />
travel originating in the United States, Canada, and Puerto Rico.<br />
Be sure to use the following discount reference number when<br />
making your reservations.<br />
Delta Airlines<br />
Before calling NAVIGANT INTERNATIONAL, please gather the<br />
following information:<br />
• The desired dates <strong>of</strong> arrival to and departure from New<br />
Orleans;<br />
• Your home city or originating airport;<br />
• Your approximate time <strong>of</strong> departure from the originating<br />
airport;<br />
• The number <strong>of</strong> persons traveling (adults/children);<br />
• Your method <strong>of</strong> payment, either credit card or check; and<br />
• Your airline frequent flyer number(s).<br />
(800) 221-1212<br />
Reference # 208610A<br />
These rates provide savings <strong>of</strong> 5–10% <strong>of</strong>f the lowest applicable<br />
fare or 10–15% <strong>of</strong>f a full coach fare, up to 30 day prior to the<br />
Annual Meeting. By staying over a Saturday night, you can take<br />
advantage <strong>of</strong> additional savings with a two-night minimum stay.<br />
You can also receive great savings on discounted fares that do not<br />
require a Saturday night stay.<br />
How To Make Air Reservations<br />
NAVIGANT INTERNATIONAL is the <strong>of</strong>ficial travel management<br />
firm for SOT’s 44 th Annual Meeting. To take advantage<br />
<strong>of</strong> their services and savings, simply call toll-free (800) 525-<br />
6061 or direct (703) 276-2030 or (703) 276-2040 and select the<br />
airfare that is right for your plans. You may use the Travel<br />
Form and fax your airline request directly to NAVIGANT<br />
INTERNATIONAL at (703) 276-2077 (available on the SOT Web<br />
site). If you prefer to e-mail your request, you may do so at:<br />
niki.markun@navigant.com.<br />
To obtain the maximum discounted fares, call NAVIGANT<br />
INTERNATIONAL at least 60 days prior to departure. A modified<br />
discounted fare is still obtainable up to 14 days in advance.<br />
These exceptional <strong>of</strong>fers are available only to SOT attendees and<br />
their guests.<br />
A. Complete the travel form (available on the SOT Web<br />
site) and fax to NAVIGANT INTERNATIONAL at<br />
(703) 276-2077.<br />
B. Or, call NAVIGANT INTERNATIONAL toll-free at<br />
(800) 525-6061 or direct (703) 276-2030 Monday through<br />
Friday, 9:00 AM–5:30 PM (Eastern Standard Time).<br />
Identify yourself as a <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> attendee. NAVIGANT<br />
INTERNATIONAL will find the best fare for you. Watch your<br />
mail. You will receive a folio containing your computerized itinerary.<br />
C. Or, call the airline directly using the toll-free numbers listed<br />
for Delta. Provide the reservationists with the reference<br />
number listed to receive the discounted airfare.<br />
Ground Transportation<br />
Airport shuttles and taxis are the best modes <strong>of</strong> transportation<br />
to and from the Louis Armstrong New Orleans International<br />
Airport. The convention center area is about 10–12 miles from<br />
the airport and is an I-10 freeway ride <strong>of</strong> about 20 minutes. All<br />
airport shuttles and taxis depart the airport from baggage claim<br />
area <strong>of</strong> the airport and will drop attendees at their hotels or at the<br />
convention center, if requested. Rental car companies have their<br />
desks located inside at baggage claim as well.<br />
Taxi<br />
A cab ride costs $28 from the airport to the Central Business<br />
District (CBD) for one or two persons and $12 (per passenger) for<br />
three or more passengers. Pick-up is on the lower level, outside<br />
the baggage claim area. There may be an additional charge for<br />
extra baggage.<br />
22<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
General Information (Continued)<br />
Airport Shuttle<br />
With Airport Shuttle, getting from the airport to your final destination<br />
has never been easier. Airport Shuttle drivers and vans<br />
provide convenient, comfortable, safe and efficient service to<br />
travelers. Airport Shuttle is the <strong>of</strong>ficial ground transportation<br />
for the Louis Armstrong New Orleans International Airport to<br />
and from downtown New Orleans hotels, the French Quarter,<br />
and the Convention Center. Shuttles depart every 15 minutes<br />
from the airport. Service is provided 24 hours per day or until<br />
the last flight arrives at Louis Armstrong Airport. All drivers are<br />
uniformed, pr<strong>of</strong>essional, courteous, and well-trained. The cost <strong>of</strong><br />
a one-way trip is $13 per person, $25 roundtrip. Tickets are sold<br />
at the Airport Shuttle ticket desk in baggage claim or purchased<br />
on-line at www.airportshuttleneworleans.com.<br />
Airport Limousine Service<br />
Non-scheduled walk up limousine and sedan service is available<br />
from the airport to the Central Business District (CBD) and the<br />
French Quarter. The rate is $35 for one or two people and $10<br />
per additional passenger for up to 8 passengers (total vehicle<br />
capacity). Limousine information desks are located on the lower<br />
level baggage claim areas.<br />
Car Rental<br />
Avis Rent A Car System is the <strong>of</strong>ficial car rental company for the<br />
44 th Annual Meeting. SOT discounted rates, including unlimited<br />
mileage, begin at $43.99 per day. Rates do not include state and<br />
local surcharges, tax, optional insurance coverage or gas fueling<br />
charges. Should a lower qualifying rate become available, Avis<br />
is pleased to present a 5% discount on that rate or, if a car size is<br />
selected that is not available, Avis will discount the best available<br />
rate by 5%. To receive the SOT discount rates, contact Avis at (800)<br />
331-1600 or AVIS on-line (www.avis.com). You must provide the<br />
Avis Worldwide Discount (AWD) number T534999 in order to<br />
receive the SOT discounted rate.<br />
For more information about how to get around New Orleans<br />
please visit: www.neworleansonline.com/guide/citymaps.<br />
Parking<br />
There are several parking lots around the convention center,<br />
including two (one outdoor, one a parking garage) directly in<br />
front <strong>of</strong> the convention center and one directly beside it. Parking<br />
starts at $7 per day.<br />
Amtrack Train<br />
The Amtrak station is located downtown in the Central Business<br />
District. There are always taxis ready and waiting at the station.<br />
Bus<br />
The New Orleans Regional Transit Authority provides bus<br />
service and streetcar service throughout New Orleans. Cost is<br />
$1.25 standard fare and $1.50 for express. Discounted all-day or<br />
multi-day passes are available at many hotels. For more information<br />
visit www.norta.com.<br />
Streetcars<br />
Other options for just enjoying the city are the Canal, St. Charles<br />
and Riverfront streetcars. Rides are $1.25 ($1.50 for Riverfront)<br />
exact change and run only within a 4-6 mile radius <strong>of</strong> the city.<br />
The streetcars are a great way to spend free time, to see City Park<br />
and the museum, the river, or historic neighborhoods; however<br />
the streetcars will not serve as a form <strong>of</strong> transportation for travel<br />
to and from the hotels and the convention center.<br />
Hotel Accommodations and<br />
Reservations<br />
Make, change, or cancel your housing reservations with our On-<br />
Line Housing Service. There you will find full hotel descriptions<br />
and reservation instructions. Be sure to scroll to the bottom <strong>of</strong> the<br />
hotel description information to reserve your hotel. The system<br />
does accept individual reservations. Upon completing your reservation<br />
on-line, an e-mail confirmation will be sent to you.<br />
HOUSING RESERVATION DEADLINE: FEBRUARY 1, 2005<br />
Please use one <strong>of</strong> the following methods to make your reservation:<br />
ON-LINE:<br />
www.toxicology.org<br />
TELEPHONE:<br />
Toll-Free (USA): (800) 424-5250<br />
International: (847) 940-2153<br />
FAX:<br />
USA: (800) 521-6017<br />
International: (847) 940-2386<br />
GENERAL INFO<br />
MAIL:<br />
SOT HOUSING BUREAU<br />
108 Wilmot Road, Suite 400<br />
Deerfield, IL 60015-0825<br />
up-to-date information at www.toxicology.org 23
44 th Annual Meeting<br />
and ToxExpo<br />
General Information (Continued)<br />
GENERAL INFO<br />
Accessibility for Persons with<br />
Disabilities<br />
The Ernest N. Morial Convention Center and most <strong>of</strong> the SOT<br />
hotels are accessible to persons with special needs. If you require<br />
special services, please mark the appropriate box on the Housing<br />
Request Form. If you require more information about disabled<br />
access, please call SOT Headquarters and ask for Heidi Prange;<br />
(703) 438-3115 ext. 1424 or heidi@toxicology.org.<br />
Guest Hospitality Center and <strong>Program</strong><br />
The SOT Guest Hospitality Center provides guest participants<br />
(non-scientists) with a place to meet and socialize with other<br />
guests. Guests must register for the Annual Meeting using the<br />
same registration form as the person they are accompanying to<br />
visit the Hospitality Center. Guests are welcome to attend the<br />
Welcoming Reception, but will not have access to the scientific<br />
sessions or the Exhibit Hall. Please remember to wear your badge<br />
to all SOT events. The Guest Hospitality Center will be located<br />
in the Hilton Riverside Hotel in the Compass Room (Sunday–<br />
Tuesday) and the Steering Room (Wednesday–Thursday).<br />
Concierge/Restaurant Reservations<br />
A representative from On the Town will be located in the registration<br />
area to provide restaurant menus, entertainment guides, and<br />
arrange restaurant reservations for individuals and groups.<br />
Meeting Requests: Hospitality Suites and<br />
Ancillary Meetings<br />
All requests for hospitality suites and ancillary meetings must<br />
be approved by SOT Headquarters. To reserve a meeting room,<br />
please contact Heidi Prange, Meetings Manager. Ancillary functions<br />
may only be hosted by SOT Affiliates, exhibitors, or<br />
organizations affiliated with SOT. Hospitality suites and ancillary<br />
meeting space books fast. Please complete the Ancillary Meeting<br />
Form at www.toxicology.org and send it to Heidi Prange.<br />
No hospitality functions or ancillary meetings may be scheduled<br />
during the following SOT events:<br />
• Sunday 5:00 PM–7:30 PM: SOT Awards Presentation and<br />
Welcoming Reception<br />
• Monday–Thursday 8:00 AM–11:30 AM: Morning SOT<br />
Scientific Sessions<br />
• Monday–Thursday 1:30 PM–4:30 PM: Afternoon SOT<br />
Scientific Sessions<br />
• Tuesday 4:30 PM–6:00 PM: SOT Annual Business Meeting<br />
Ancillary requests received after December 15, 2004 may not be<br />
published in the SOT <strong>Program</strong>.<br />
The hotels are not permitted to book meeting space without the<br />
authorized approval from SOT HQ. However, you are welcome<br />
to contact the Convention Service Manager to discuss meeting<br />
room rental, food and beverage, and audio visual equipment<br />
requests. All coordination for your event should be done between<br />
the hotel Convention Service Manager and the Ancillary Function<br />
Organizer.<br />
Message Center/Lodging Information Desk<br />
The SOT Message Center/Lodging Information Desk will be<br />
located in the SOT registration area <strong>of</strong> the Ernest N. Morial<br />
Convention Center and open during registration hours, Saturday<br />
through Thursday. Please inform your <strong>of</strong>fice and family <strong>of</strong><br />
the Message Center/Lodging Information Desk number<br />
(504) 670-6900. (The Message Center/Lodging Information Desk<br />
will not accept facsimiles.)<br />
Convention Center First Aid and Security<br />
The Ernest N. Morial Convention Center has an on-site, ACLScertified<br />
registered nurse, stationed in permanent medical rooms<br />
located in Lobby B, Lobby E, and Lobby H during move-in,<br />
move-out and event hours. Medical facilities are clearly identified<br />
with visual and braille signs. Outside each room is an emergency<br />
phone directly connected to the Public Safety Department.<br />
To report an emergency:<br />
Pick up the RED emergency telephone in any telephone bank—<br />
dial 1911 or 3040 from any non-coin operated telephone. Use the<br />
emergency telephone in the GREEN box outside the medical<br />
rooms in Lobby B, Lobby E or Lobby H.<br />
About Safety and Security:<br />
The possibility <strong>of</strong> demonstrators is very real given the nature <strong>of</strong><br />
our conference. Emergencies <strong>of</strong> this nature range from verbal<br />
confrontations, protests, strikes or riots. We recommend the<br />
following procedures in the event <strong>of</strong> demonstrations:<br />
• Wear your name badge in the convention center. When leaving<br />
the facility, remove it so as to blend with other people.<br />
• If you see a demonstration or protest beginning, please<br />
contact any member <strong>of</strong> the SOT Annual Meeting staff and<br />
they will initiate SOT response. If you see actions that appear<br />
threatening, notify the nearest security <strong>of</strong>ficer.<br />
• Do not engage, defend either side, or subdue person(s) in<br />
any type <strong>of</strong> disturbance. Demonstrators are usually trying to<br />
attract media attention. Don’t help them!<br />
24<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
General Information (Continued)<br />
• SOT Representatives will respond to media inquiries. Do not<br />
participate in interviews or other media responses.<br />
• In the unlikely event that outsiders disrupt a scientific<br />
session or other event, SOT security <strong>of</strong>ficials have developed<br />
a contingency plan. Please follow directions from the<br />
chairperson and avoid becoming involved in the situation.<br />
Our first priority is safety. The best way to stay safe is to be aware<br />
<strong>of</strong> your surroundings and to avoid situations where you feel<br />
uncomfortable.<br />
SOT Headquarters Office<br />
Ernest N. Morial Convention Center, 205<br />
Sunday .................................................................. 7:00 AM–5:00 PM<br />
Monday ................................................................. 7:00 AM–5:00 PM<br />
Tuesday ................................................................. 8:00 AM–4:00 PM<br />
Wednesday ........................................................... 8:00 AM–4:00 PM<br />
Thursday ............................................................ 8:00 AM–11:30 AM<br />
Business Center at the Ernest N. Morial<br />
Convention Center<br />
A Business Center is conveniently located in the Atrium <strong>of</strong> the<br />
Ernest N. Morial Convention Center.<br />
Saturday–Thursday ............................................ 8:00 AM–6:00 PM<br />
• Copies • Fax Service • International Calls<br />
• Office Supplies • Parcel Shipping • Internet Access*<br />
*Internet access is only available in the main store, located across the<br />
street from Hall C.<br />
Contact Matthew Sylvester at:<br />
Tel: (504) 524–0009; Fax; (504) 670–8996<br />
E-mail: rhino@rhinobiz.com<br />
Stay Connected While You Travel<br />
As technology advances, SOT realizes how important it is for<br />
attendees to learn the latest scientific discoveries and use technology<br />
to stay connected to daily responsibilities while attending<br />
the meeting. This year SOT will have stations available in<br />
ToxExpo to check your e-mail and connect to the Internet. In<br />
addition, selected lounge areas in the Exhibit Hall <strong>of</strong>fer wireless<br />
Internet access. Additional information and instructions for<br />
accessing the wireless connection are available on the Annual<br />
Meeting Web site. All computer equipment at the computer<br />
stations was graciously supplied by Dell.<br />
Media Representative Registration/Media<br />
Workspace (SOT HQ Office)<br />
Ernest N. Morial Convention Center, 205<br />
Sunday–Thursday, March 5–10 ..................(See SOT Office Hours)<br />
Registration fees are waived for working reporters and public<br />
information <strong>of</strong>ficers. Pro<strong>of</strong> <strong>of</strong> credentials includes a recognized<br />
press card, business card, or letter on <strong>of</strong>ficial letterhead from<br />
an editor <strong>of</strong> a publication or a producer <strong>of</strong> a program, certifying<br />
that you are covering the conference for their respective<br />
organizations.<br />
There will be working space for the media in the SOT Office.<br />
For more information, contact Lilly Richards, Media Contact, at<br />
(703) 438-3115, Ext. 1454, or e-mail: lilly@toxicology.org.<br />
Annual Meeting Sponsorship<br />
The <strong>Society</strong> would like to invite your organization to be a<br />
proud sponsor <strong>of</strong> the 2005 Annual Meeting. SOT appreciates the<br />
generous contributions <strong>of</strong> sponsors that make the SOT Annual<br />
Meeting possible. Sponsor names are prominently displayed<br />
on the Annual Meeting and ToxExpo Web sites as well as in<br />
print materials that are distributed before and during the Annual<br />
Meeting. Sponsorship is recognized through signage displayed<br />
around the convention center during the Annual Meeting.<br />
There are five levels <strong>of</strong> sponsorship available: Diamond (over<br />
$10,000), Platinum ($5,000–$9,999), Gold ($2,500– $4,999), Silver<br />
($1,000–$2,499) and Contributor ($500–$999). You will find a<br />
complete menu <strong>of</strong> sponsorships designed to assist your organization<br />
in establishing a leadership position at the SOT 2005 Annual<br />
Meeting on the Web site at www.toxicology.org and promotional<br />
opportunities can be reviewed at www.toxexpo.com.<br />
For detailed information about SOT sponsor and promotional<br />
opportunities, please contact Libby Jones; (703) 438-3115 or<br />
libby@toxicology.org.<br />
GENERAL INFO<br />
up-to-date information at www.toxicology.org 25
44 th Annual Meeting<br />
and ToxExpo<br />
General Information (Continued)<br />
GENERAL INFO<br />
Speaker Ready Room<br />
Ernest N. Morial Convention Center, 202<br />
Saturday .................................................................4:00 PM–7:00 PM<br />
Sunday .................................................................. 7:00 AM–5:30 PM<br />
Monday–Wednesday .......................................... 7:00 AM–5:00 PM<br />
Thursday ............................................................ 7:00 AM–11:30 AM<br />
Meeting Courtesy Policy<br />
The use <strong>of</strong> photographic equipment is prohibited in all<br />
scientific sessions. Please contact Show Management, Libby Jones,<br />
for permission to take pictures in the Exhibit Hall. In addition,<br />
please turn <strong>of</strong>f sound on all cellular phones while attending scientific<br />
sessions. Note that the entire Ernest N. Morial Convention<br />
Center is a smoke-free environment.<br />
SOT Memorabilia<br />
Shirts, portfolios and other items customized for SOT are<br />
available for ordering on-line for pick-up at the Annual<br />
Meeting. Visit the SOT Web site’s 2005 Annual Meeting Section<br />
(www.toxicology.org) for full details.<br />
Career Resource and Development Services<br />
SOT’s on-line job bank makes it easy for candidates and employers<br />
alike to access the Career Resource and Development Service<br />
from the main SOT Web site at www.toxicology.org throughout<br />
the year. Registrations are continuously processed and valid for<br />
six months. Once registered, candidates may search the listing<br />
<strong>of</strong> available jobs and employers may browse candidate pr<strong>of</strong>iles.<br />
During the registration period, users can update their listings or<br />
search the database as <strong>of</strong>ten as they wish. Communication with<br />
a desired employer or candidate can even be made via e-mail<br />
messages created within the system.<br />
The Career Resource and Development Center is an important<br />
part <strong>of</strong> the Annual Meeting, providing a coordinated service<br />
for information regarding career opportunities and qualified<br />
candidates. Please do your job and candidate searches before<br />
you arrive at the meeting. Access to the SOT job bank Web site<br />
in the Career Resource and Development Center will be limited<br />
to the availability <strong>of</strong> 4 computers at the meeting. Employers and<br />
candidates will have access to computers, but computer use will<br />
be restricted to short searches for updates or new information.<br />
Although pre-registration is encouraged, registrations will be<br />
accepted at the Annual Meeting. SOT Student Members who<br />
register for the Career Resource and Development Service before<br />
the SOT Annual Meeting will not be charged the $20 on-site<br />
registration fee. Please note that you must be a Student Member<br />
<strong>of</strong> SOT to register in this category. All users with current registrations<br />
at the time <strong>of</strong> the Annual Meeting will be permitted to use<br />
the service.<br />
For additional information contact Nichelle Sankey at SOT<br />
Headquarters; (703) 438-3115 or nichelle@toxicology.org.<br />
26<br />
SOT's 44 th Annual Meeting
2005 Award Winners<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> presented the following awards for the year 2005:<br />
Arnold J. Lehman Award<br />
Rory<br />
Conolly<br />
Dr. Rory B. Conolly’s contributions as a<br />
leader in the incorporation <strong>of</strong> good science<br />
in risk assessment and regulatory decisions<br />
are consistent with the spirit <strong>of</strong> the Arnold<br />
J. Lehman Award. He has had a significant<br />
influence on many important risk assessment<br />
decisions and documents within the U.S.<br />
government and industry. Even more importantly,<br />
his knowledge plus his communication<br />
skills have created a lasting appreciation by<br />
many <strong>of</strong> his “students” for the importance <strong>of</strong><br />
computational biology methods in the field<br />
<strong>of</strong> risk assessment.<br />
Dr. Conolly’s experience with physiologically-based pharmacokinetic<br />
modeling has resulted in his being widely sought by<br />
governmental, industrial, and academic organizations to design and<br />
interpret studies involving the science <strong>of</strong> non-cancer risk assessment<br />
and cancer risk assessment modeling. He has provided expert testimony<br />
before Congress, participated in the preparation <strong>of</strong> several<br />
water quality criteria monographs for EPA, and has conducted risk<br />
assessment activities on behalf <strong>of</strong> NIOSH, NIEHS, IPCS, FDA and<br />
the SOT. Dr. Conolly stands out among his colleagues as a leader in<br />
the inclusion <strong>of</strong> good science in risk assessment.<br />
Board <strong>of</strong> Publications Award in<br />
Toxicological Sciences<br />
The Board <strong>of</strong> Publications has unanimously<br />
selected the paper entitled Arsenic Stimulates<br />
Angiogenesis and Tumorigenesis In Vivo as the<br />
best paper published in Toxicological Sciences<br />
during the past year. The joint first authors <strong>of</strong><br />
this paper are Nicole V. Soucy and Michael<br />
A. Ihnat. The co-authors are Chandrashekhar<br />
D. Kamat, Linda Hess, Mark J. Post, Linda<br />
R. Klei, Callie Clark and Aaron Barchowsky<br />
(ToxSci. 76, 271–279, 2003).<br />
Although arsenicals have been used for treating a variety <strong>of</strong> cancers<br />
including acute or chronic leukemias and solid tumors, their clinical<br />
use and environmental exposures are also associated with significant<br />
adverse effects on the cardiovascular system. One hypothesis<br />
for the antitumor effects <strong>of</strong> trivalent arsenic As (III) is that it inhibits<br />
angiogenesis. At the same time, however, there is conflicting<br />
evidence that As (III) is also directly angiogenic in cell culture. The<br />
significance <strong>of</strong> the work reported by Soucy et al. is that the paper<br />
represents the first report <strong>of</strong> the effects <strong>of</strong> As (III) on angiogenesis<br />
in vivo. The authors used both avian and mammalian models to<br />
test the hypothesis that As (III) stimulated angiogenesis and tumor<br />
growth in a dose-dependent manner. The authors showed that<br />
As (III) increased blood vessel density in the chick chorioallantoic<br />
membrane and mouse Matrigel models. Additionally, they demonstrated<br />
that As (III) increased the size and density <strong>of</strong> blood vessels<br />
<strong>of</strong> solid tumors growing in a nude mouse model while enhancing<br />
tumor growth and metastatic potential. Importantly, the authors’<br />
work revealed a complex, non-linear dose-response relationship,<br />
with pro-angiogenic properties observed at levels relevant to environmental<br />
exposure.<br />
Although the work has not fully characterized the mechanisms<br />
underlying the angiogenic properties <strong>of</strong> As (III), the results represent<br />
important new data that impact human health. In particular,<br />
the work provides new information regarding the scientific underpinning<br />
<strong>of</strong> the carcinogenicity <strong>of</strong> As (III) and the potential for<br />
adverse health effects <strong>of</strong> environmental exposure to As (III) while<br />
documenting a very narrow therapeutic window when treating<br />
solid tumors with arsenic. The paper is an outstanding example<br />
<strong>of</strong> a relevant, hypothesis-driven approach to address an important<br />
human health concern.<br />
Contributions to Public Awareness <strong>of</strong><br />
Animal Welfare Award<br />
This year, the Awards Committee has selected two recipients for<br />
Contributions to the Public Awareness <strong>of</strong> the Importance <strong>of</strong> Animals<br />
in <strong>Toxicology</strong> Research Award.<br />
FBR, Frankie L.<br />
Trull, President<br />
Orrin G.<br />
Hatch<br />
The first recipient is the Foundation for<br />
Biomedical Research, which has provided<br />
valuable educational resources supporting the<br />
use <strong>of</strong> animals systems for providing invaluable<br />
and irreplaceable insights into human<br />
systems. These resources include articles elaborating<br />
the contributions <strong>of</strong> animal research,<br />
materials for both teachers and parents <strong>of</strong><br />
children in primary and secondary schools,<br />
and links to other federal agencies and foundation<br />
web sites that support and address the<br />
needs <strong>of</strong> animals in biomedical research.<br />
The second recipient is Senator Orrin Hatch,<br />
a long-time supporter <strong>of</strong> biomedical research.<br />
Senator Hatch, as Chair <strong>of</strong> the Senate Judiciary<br />
Committee has held hearings on the subject <strong>of</strong><br />
“Animal Rights: Activism vs. Criminality”<br />
to call attention to the rising incidence <strong>of</strong><br />
terrorist like activities associated with some<br />
animal rights group. He will hold another<br />
committee meeting on the topic <strong>of</strong> Animal<br />
Rights/Activism in late 2004 or early 2005<br />
with the intent <strong>of</strong> initiating legislation to<br />
protect universities and research organizations<br />
from such groups’ illegal and violent<br />
activities.<br />
AWARDS<br />
up-to-date information at www.toxicology.org 27
2005 Award Winners (Continued)<br />
AWARDS<br />
Distinguished Lifetime <strong>Toxicology</strong><br />
Scholar Award<br />
Daniel<br />
Nebert<br />
This year’s recipient <strong>of</strong> the Distinguished<br />
Lifetime <strong>Toxicology</strong> Scholar Award is<br />
Dr. Daniel Nebert, Pr<strong>of</strong>essor in the Department<br />
<strong>of</strong> Environmental Health, University <strong>of</strong><br />
Cincinnati School <strong>of</strong> Medicine. Dr. Nebert<br />
received his M.D. degree from the University<br />
<strong>of</strong> Oregon Medical School, completed his<br />
residency training and joined the National<br />
Institutes <strong>of</strong> Health where he held several<br />
research leadership positions in the National<br />
Institute <strong>of</strong> Child Health and Human<br />
Development. In 1989, he joined the faculty<br />
at the University <strong>of</strong> Cincinnati where he holds<br />
cross-appointments in several Departments<br />
and <strong>Program</strong>s.<br />
Dr. Nebert continues to be one <strong>of</strong> the most productive and influential<br />
scientists <strong>of</strong> our time. He is the author <strong>of</strong> over 500 publications and<br />
his research on cytochrome P450 (CYP) regulation drug and carcinogen<br />
metabolism has significantly impacted the fields <strong>of</strong> toxicology,<br />
pharmacology, genetics, endocrinology, oncology, biochemistry and<br />
molecular biology. He has contributed seminal research publications<br />
to all <strong>of</strong> these fields and his pioneering efforts on organizing<br />
and classifying the CYP superfamily are a model for understanding<br />
gene relationships in many other gene families. Dr. Nebert has<br />
received honors from numerous scientific societies, government,<br />
and universities and in his lectures he not only provides historical<br />
scientific insights but also cutting-edge pharmacogenetic research<br />
results. Not surprisingly, Dr. Nebert is one <strong>of</strong> the most highly cited<br />
scientists in his field.<br />
Nobuyuki<br />
Ito<br />
Education Award<br />
The recipient <strong>of</strong> the 2005 Education Award is<br />
Dr. Nobuyuki Ito. Dr. Ito began his pioneering<br />
efforts in toxicology education 30 years ago<br />
when he established an extensive teaching<br />
and training program for toxicologists at<br />
the Nagoya City University Medical School,<br />
Department <strong>of</strong> Pathology. He has trained<br />
two generations <strong>of</strong> toxicologists and toxicologic<br />
pathologists in Japan, first as Chairman<br />
<strong>of</strong> the Department, then as Dean <strong>of</strong> the<br />
Medical School and lastly as President <strong>of</strong> the<br />
University. Dr. Ito and his students and senior<br />
scientists have made major and significant<br />
contributions to risk assessment and regulation<br />
<strong>of</strong> chemicals and food additives in Japan, in the U.S. and<br />
internationally. His work in the field <strong>of</strong> histogenesis and modulation<br />
<strong>of</strong> the neoplastic process and his work on the role <strong>of</strong> antioxidants<br />
in anticarcinogenesis have been acknowledged by many learned<br />
societies, including the Princess Takamatsu Cancer Research Fund,<br />
the Japanese Cancer Association, and the Federation <strong>of</strong> Societies <strong>of</strong><br />
Toxicologic Pathology. During his distinguished career at Nagoya<br />
City University Medical School, Dr. Ito has authored and coauthored<br />
with his numerous students and associates more than<br />
600 peer-reviewed scientific publications. His former students,<br />
numbering more than 100, are in very important positions around<br />
the world, continuing his task <strong>of</strong> educating toxicologists in Japan,<br />
Korea, Brazil and the U.S. This years’ Education Award celebrates<br />
Dr. Ito’s lifelong contributions to education.<br />
Research in Dr. Nebert’s laboratory has been carried out by a long<br />
list <strong>of</strong> graduate students, post-doctoral fellows, research associates,<br />
and visiting scientists. Many <strong>of</strong> these individuals are now distinguished<br />
scientists in their own right and their success has been<br />
significantly influenced by Dr. Nebert’s mentorship and collaboration.<br />
This combination <strong>of</strong> inspired research and mentorship, coupled<br />
with insightful new ideas and hypotheses, defines the scientific<br />
career <strong>of</strong> Dr.Nebert and is consistent with the award <strong>of</strong> the 2005<br />
Distinguished Lifetime <strong>Toxicology</strong> Scholar Award from the <strong>Society</strong><br />
<strong>of</strong> <strong>Toxicology</strong>.<br />
28<br />
SOT's 44 th Annual Meeting
2005 Award Winners (Continued)<br />
Enhancement <strong>of</strong> Animal Welfare<br />
Daniel<br />
Acosta<br />
Dr. Daniel Acosta, Dean <strong>of</strong> the College <strong>of</strong><br />
Pharmacy at the University <strong>of</strong> Cincinnati,<br />
is the 2005 recipient <strong>of</strong> the Enhancement <strong>of</strong><br />
Animal Welfare Award. This award was instituted<br />
in 2000 to honor a member <strong>of</strong> the <strong>Society</strong><br />
<strong>of</strong> <strong>Toxicology</strong> whose scientific accomplishments<br />
have led to a marked reduction in<br />
the use <strong>of</strong> experimental animals for research.<br />
Dr. Acosta was one <strong>of</strong> the early pioneers in the<br />
development <strong>of</strong> in vitro cell cultures as models<br />
for testing and mechanistic studies on drugs<br />
and toxicants. He, his co-workers, and other<br />
scientists in this field developed appropriate<br />
conditions for culturing cells from various<br />
tissues that mimicked their derived normal tissues, thus greatly<br />
reducing the need for experimental animal testing. Dr. Acosta was<br />
not only a pioneer in developing alternative in vitro test methods,<br />
but he was successful in maintaining viable cultured cells from<br />
multiple sites including liver, heart, kidney, and nervous tissues. In<br />
addition to his scientific accomplishments in the field <strong>of</strong> in vitro toxicology,<br />
Dr. Acosta has been an outstanding mentor teacher/lecturer,<br />
and he is also a former President <strong>of</strong> the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>.<br />
Dr. Acosta’s long-term contributions to in vitro toxicology have<br />
greatly decreased the use <strong>of</strong> animals in research, and he is recognized<br />
and honored for his accomplishments with the 2005 Enhancement <strong>of</strong><br />
Animal Welfare Award.<br />
Roger O.<br />
McClellan<br />
Merit Award<br />
The Awards Committee is honored to select<br />
Roger O. McClellan, DVM, MMS, DABT,<br />
DABVT, FATS, as the 2005 Merit Award<br />
recipient. Dr. McClellan is well recognized<br />
for distinguished accomplishments in several<br />
areas: his pioneering and productive research<br />
career; a legacy <strong>of</strong> leadership through both<br />
his impact on the development <strong>of</strong> renowned<br />
research institutes and the fostering <strong>of</strong> educational<br />
programs; and for significant service as<br />
a scientific advisor to numerous national and<br />
international agencies, academic institutions,<br />
and pr<strong>of</strong>essional and private organizations.<br />
Dr. McClellan has had an extensive, productive and influential<br />
research career. He has authored or co-authored more than 350<br />
scientific papers and has edited or co-edited 10 books in the fields<br />
<strong>of</strong> inhalation toxicology, comparative medicine, and human health<br />
risk analysis. By virtue <strong>of</strong> his unique vision, he is recognized for<br />
pioneering many influential studies that served as the cornerstone<br />
for subsequent research and which have had tremendous influence<br />
on subsequent regulatory decisions.<br />
In 1966, at an early age, Dr. McClellan assumed leadership <strong>of</strong> the<br />
Lovelace Inhalation <strong>Toxicology</strong> Research Institute (ITRI) and subsequently<br />
became its President. The ITRI continues today as part <strong>of</strong><br />
the Lovelace Respiratory Research Institute. Under his leadership,<br />
Lovelace became an internationally recognized institute known for<br />
its high-quality studies <strong>of</strong> the toxicity <strong>of</strong> radioactive and chemical<br />
airborne pollutants. He introduced strategic, innovative, and multidisciplinary<br />
approaches and championed teamwork to advance the<br />
analysis <strong>of</strong> complex environmental and occupational exposures.<br />
In 1988, Dr. McClellan became the third President <strong>of</strong> the Chemical<br />
Industry Institute <strong>of</strong> <strong>Toxicology</strong> (CIIT, now CIIT Centers for Health<br />
Research). During his tenure with CIIT, he enhanced its reputation<br />
as a world leader in understanding the human health risks <strong>of</strong> chemical<br />
exposures. There he solidified the concept <strong>of</strong> using all available<br />
data, from epidemiological to subcellular studies, to predict health<br />
consequences at exposures relevant to people.<br />
Dr. McClellan has been notably generous in service to a number<br />
<strong>of</strong> pr<strong>of</strong>essional organizations, including presiding as President <strong>of</strong><br />
the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>, the <strong>Toxicology</strong> Education Foundation,<br />
the American Board <strong>of</strong> Veterinary <strong>Toxicology</strong>, and the American<br />
Association for Aerosol Research. He serves in an editorial role for<br />
several journals and as the Editor <strong>of</strong> Critical Reviews in <strong>Toxicology</strong>.<br />
He is a diplomate <strong>of</strong> both the American Board <strong>of</strong> <strong>Toxicology</strong> and<br />
the American Board <strong>of</strong> Veterinary <strong>Toxicology</strong>, and a Fellow <strong>of</strong><br />
The Academy <strong>of</strong> Toxicological Sciences, <strong>Society</strong> for Risk Analysis,<br />
Health Physics <strong>Society</strong> and American Association for Advancement<br />
<strong>of</strong> Science. He has served on the adjunct faculty <strong>of</strong> eight academic<br />
institutions and is a frequent advisor on toxicology and human risk<br />
issues to both public agencies and private parties in the U.S. and<br />
abroad.<br />
Dr. McClellan’s significant contributions have been previously<br />
recognized by a number <strong>of</strong> honors. Among them are the following:<br />
election to membership in the Institute <strong>of</strong> Medicine <strong>of</strong> the National<br />
Academy <strong>of</strong> Sciences; two Distinguished Associate Awards from the<br />
Department <strong>of</strong> Energy for outstanding scientific vision and research<br />
leadership in inhalation toxicology, radiation biology, and environmental<br />
health sciences; an International Aerosol Fellow Award from<br />
the International Aerosol Research Assembly for outstanding contributions<br />
to aerosol science and technology; the Thomas T. Mercer<br />
Joint Prize from the American Association for Aerosol Research and<br />
the International <strong>Society</strong> for Aerosols in Medicine for excellence in<br />
the field <strong>of</strong> inhalation materials and pharmaceutical aerosols; an<br />
International <strong>Society</strong> <strong>of</strong> Regulatory <strong>Toxicology</strong> and Pharmacology<br />
award for outstanding contributions to improving the science for<br />
risk-based decision making; Distinguished Alumnus Awards from<br />
Washington State University and the University <strong>of</strong> New Mexico; a<br />
career achievement award from the Inhalation Specialty Section <strong>of</strong><br />
the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>; and the Arnold J. Lehman Award from<br />
the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> for major contributions to the control <strong>of</strong><br />
chemical agents.<br />
For his outstanding scientific career, his leadership in directing and<br />
advancing key issues in toxicology and human health risk analysis,<br />
and for his distinguished service record, the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong><br />
is pleased to bestow the 2005 Merit Award to Dr. McClellan as an<br />
additional and well-deserved honor. For his outstanding scientific<br />
career, his leadership in directing and advancing several key<br />
issues in toxicology and human health risk analysis, and for his<br />
distinguished service record, the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> is pleased to<br />
bestow the 2005 Merit Award to Dr. McClellan as an additional and<br />
well-deserved honor.<br />
AWARDS<br />
up-to-date information at www.toxicology.org 29
2005 Award Winners (Continued)<br />
AWARDS<br />
Public Communications Award<br />
Robert<br />
Kreiger<br />
Dr. Robert I. Krieger, an Extension Toxicologist,<br />
Department <strong>of</strong> Entomology, at the University<br />
<strong>of</strong> California, Riverside, has been selected<br />
to receive the 2005 Public Communications<br />
Award. Dr. Krieger is a distinguished research<br />
investigator who has contributed over 100<br />
technical articles published in the peerreviewed<br />
literature. He also served as senior<br />
editor <strong>of</strong> the 2nd Edition <strong>of</strong> the Handbook <strong>of</strong><br />
Pesticide <strong>Toxicology</strong>, a text familiar to most<br />
toxicology students. Dr. Krieger’s university<br />
lectures are among the best. In addition,<br />
his commitment to meeting the challenge <strong>of</strong><br />
clearly communicating critical concepts <strong>of</strong><br />
toxicology to non-technical audiences is exemplary.<br />
Dr. Krieger’s public outreach is across a range <strong>of</strong> audience and<br />
toxicology topics that has spanned from speaking to kindergarten<br />
students on blow gun dart poison, to town-forum meetings<br />
discussing the risk <strong>of</strong> exposure to malathion due to drift from<br />
aerial sprayings against Medfly outbreaks. The variety <strong>of</strong> venues to<br />
which he diligently directs his participation is also notably broad,<br />
and includes the following: mentoring contestants and judging<br />
entries at grade-school science fairs; continuing education lectures<br />
to pesticide user groups, migrant laborers, parents, teachers, and<br />
consumers; providing expert witness in a number <strong>of</strong> jury trials<br />
where complex toxicological issues had to be explained in understandable<br />
terms; media reports and newspaper or radio interviews;<br />
and as a technical advisor to television shows such as CSI Miami.<br />
Dr. Krieger also has aided deliberations convened by legislative<br />
bodies or advisory committees on health policy. For example, he<br />
assisted the Federal Trade Commission in the evaluation <strong>of</strong> the efficacy<br />
<strong>of</strong> vegetable and produce washes. Dr. Krieger’s publication on<br />
the use <strong>of</strong> mosquito coils in Asia and their subsequent withdrawal<br />
from use in Indonesia demonstrates an international impact.<br />
AstraZeneca Traveling Lectureship<br />
Kevin<br />
Cr<strong>of</strong>ton<br />
This year’s recipient <strong>of</strong> the AstraZeneca<br />
Traveling Lectureship Award is Dr. Kevin<br />
M. Cr<strong>of</strong>ton. Dr. Cr<strong>of</strong>ton is a neurotoxicologist<br />
with the Neurotoxicology Division <strong>of</strong> the<br />
National Health and Environmental Effects<br />
Laboratory, U.S. Environmental Protection<br />
Agency, Research Triangle Park, North<br />
Carolina. His primary research interest is the<br />
effects <strong>of</strong> thyroid disrupting chemicals on the<br />
ontogeny <strong>of</strong> the nervous system. Dr. Cr<strong>of</strong>ton<br />
has presented invited lectures in the U.S.,<br />
Europe, and Canada and currently serves on<br />
the Editorial Boards <strong>of</strong> several scientific journals.<br />
Dr. Cr<strong>of</strong>ton’s traveling lectureship is in<br />
support <strong>of</strong> the development <strong>of</strong> a new program within EPA to implement<br />
and validate the use <strong>of</strong> high-throughput in vitro methods and<br />
alternative species as first-tier screening methods for developmental<br />
neurotoxicity. His lectureship will include visits with Dr. Sandra<br />
Coecke, Development Coordinator Metabolism and Neurotoxicity<br />
at ECVAM Institute for Health and Consumer Protection, European<br />
Commission, Joint Research Center, Ispra, Italy; Dr. Adrian Percy <strong>of</strong><br />
Bayer Crop Science, Sophia Antipolis Research Center in France and<br />
Dr. David Ray <strong>of</strong> the MRC Applied Neuroscience Group, Biomedical<br />
Sciences at the University <strong>of</strong> Nottingham, Queens Medical Centre in<br />
Nottingham, England.<br />
His scientific expertise, coupled with unique oral communication<br />
skills and enthusiasm, make Dr. Krieger very effective at presenting<br />
a balanced, scientific perspective. Such a perspective is absolutely<br />
essential to ensuring that the principles, findings, extrapolations,<br />
and uncertainties that underlie toxicological assessments, public<br />
concerns, and regulatory strategies are all equally understood by<br />
citizens, stakeholders, and decision makers alike. In so doing, he<br />
has advanced the understanding and acceptance <strong>of</strong> toxicology as a<br />
scientific discipline critically relevant to enhancing human, animal,<br />
and environmental health. The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> is pleased to<br />
recognize Dr. Krieger for his outstanding efforts both to communicate<br />
clearly and to soundly educate a diverse audience on the<br />
fundamentals <strong>of</strong> our pr<strong>of</strong>ession.<br />
30<br />
SOT's 44 th Annual Meeting
2004 Student Award Winners<br />
Colgate-Palmolive Post-Doctoral Fellowship in In Vitro <strong>Toxicology</strong><br />
Abstract: 1367<br />
Title: BCL-2 Family Members Protect against<br />
Methoxychlor-Induced Toxicity <strong>of</strong> Mouse Ovarian<br />
Antral Follices In Vitro<br />
Kimberly<br />
Miller<br />
AWARDS<br />
Novartis Corporation Graduate Fellowship<br />
Abstract: 1930<br />
Title: Augmentation <strong>of</strong> Lipopolysaccharide-Induced<br />
Gene Expression and Liver Injury by Ranitidine but<br />
not Famotidine<br />
James<br />
Luyendyk<br />
Visit the SOT Web site for upcoming award details and deadlines at…<br />
www.toxicology.org<br />
up-to-date information at www.toxicology.org 31
Social Events<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Awards Presentation<br />
Sunday, March 6, 5:15 PM–6:30 PM<br />
Room 220<br />
Ernest N. Morial Convention Center<br />
Join us as SOT honors our prestigious<br />
award winners at the Award<br />
Presentation. Please refer to the<br />
Awards and Fellowships section <strong>of</strong><br />
the SOT Web site for complete details<br />
and nominating form for next year.<br />
Student/Post-Doctoral Fellow Mixer<br />
Sunday, March 6, 7:30 PM–8:30 PM<br />
Grand Ballroom A<br />
Hilton Riverside Hotel<br />
All students and post-docs are<br />
invited to attend this fun-filled reception.<br />
Refreshments will be provided<br />
by SOT and sponsors. A cash bar will<br />
also be available. Ticket and Meeting<br />
Badges are required.<br />
Welcoming Reception<br />
Sunday, March 6, 6:30 PM–7:30 PM<br />
La Louisiane Ballroom<br />
Ernest N. Morial Convention Center<br />
The Welcoming Reception is a great<br />
opportunity to renew old friendships<br />
and to make new acquaintances.<br />
Please join the <strong>Society</strong> in this inaugural<br />
event <strong>of</strong> the Annual Meeting.<br />
Specialty Section Receptions<br />
Monday, March 7 through Wednesday, March 9,<br />
6:00 PM–7:30 PM<br />
Ernest N. Morial Convention Center<br />
(Refer to the Events Calendar for more details.)<br />
Each <strong>of</strong> the 20 SOT Specialty Sections will hold a meeting/<br />
reception during the 2005 SOT Annual Meeting. All current and<br />
prospective SOT Specialty Section Members are encouraged to<br />
attend. Please check the <strong>Program</strong>’s Event Calendar for a listing<br />
<strong>of</strong> times for all Specialty Section meetings and receptions.<br />
SOCIAL EVENTS<br />
25-Year (or More) Member<br />
Reception<br />
Sunday, March 6, 7:00 PM–8:00 PM<br />
Room 215<br />
Ernest N. Morial Convention Center<br />
Have you been a member <strong>of</strong> the<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> for 25 years<br />
(or more)? If so, please join your<br />
colleagues in celebration and recognition<br />
<strong>of</strong> the scientists who established<br />
the <strong>Society</strong>.<br />
Regional Chapter Receptions<br />
Monday, March 7 through Wednesday, March 9,<br />
7:00 PM–11:00 PM<br />
Hilton Riverside Hotel<br />
(Refer to the Events Calendar for more details.)<br />
Many <strong>of</strong> the SOT Regional Chapters meet during the SOT<br />
Annual Meeting. A list <strong>of</strong> Regional Chapter receptions will be<br />
listed in the <strong>Program</strong>’s Event Calendar.<br />
up-to-date information at www.toxicology.org 32
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index<br />
SESSION INDEX<br />
Continuing Education Courses<br />
All courses will be held on Sunday, March 6, 2005, at the Ernest<br />
N. Morial Convention Center. Please check the signage in the<br />
registration area for room assignments. Note: Your course materials<br />
will be available in the room immediately prior to the course<br />
(they will not be available at the registration area). If you have<br />
your course ticket, go directly to the assigned course room. If you<br />
have not received your course ticket or have not registered, please<br />
go to the registration area on Saturday afternoon/evening or on<br />
Sunday morning. If you have misplaced your ticket, please go to<br />
the Continuing Education Booth, Level 2, at the Ernest N. Morial<br />
Convention Center on Sunday. The booth will be open from<br />
6:30 AM–5:15 PM. Course descriptions are on pages 39–45.<br />
7:00 AM–7:45 AM, Sunrise Mini–Course:<br />
1. Fundamentals <strong>of</strong> Nanotechnology: Chemistry, Exposure,<br />
Environmental/Health Assessments and Societal Impacts<br />
8:15 AM–12:00 PM, Morning Courses:<br />
2. Dose Considerations for In Vitro Studies <strong>of</strong> Air Pollutant Toxicity<br />
3. Developmental <strong>Toxicology</strong> Studies: Design, Interpretation and Risk<br />
Assessment<br />
4. Clinical Pathology—The Granddaddy <strong>of</strong> Biomarkers<br />
5. Immunology for Toxicologists<br />
6. Evaluation <strong>of</strong> Cardiac Drug Toxicity in Pharmaceutical Discovery<br />
and Development<br />
7. International Harmonization <strong>of</strong> Technical Requirements<br />
for Conducting Non–Clinical Safety Studies <strong>of</strong> Human<br />
Pharmaceuticals: Guidelines, Case Studies, and Challenges<br />
1:15 PM–5:00 PM, Afternoon Courses:<br />
8. Male Reproductive Hazard Identification and Risk Assessment in<br />
Pharmaceutical Development (What Do You Do Now That You<br />
Have A Signal?)<br />
9. Development and Interpretation <strong>of</strong> Toxicokinetic Data for Risk and<br />
Safety Assessment<br />
10. Phototoxicity: Current Concepts, Experimental Designs, and<br />
Regulatory Expectations<br />
11. Something Old, Something New; Traditional and Novel Biomarkers<br />
<strong>of</strong> Renal Injury<br />
12. Evaluation <strong>of</strong> Cardiac Drug Toxicity in Pharmaceutical Discovery<br />
and Development<br />
13. International Harmonization <strong>of</strong> Technical Requirements<br />
for Conducting Non-Clinical Safety Studies <strong>of</strong> Human<br />
Pharmaceuticals: Guidelines, Case Studies, and Challenges<br />
General Scientific Sessions<br />
(Listed by date and time.)<br />
Symposia<br />
Monday<br />
Date/Time Topic/Abstract # Room Page<br />
Monday The Future <strong>of</strong> Molecular RO4 49<br />
9:30 AM Genetic Therapeutics #13–17<br />
Monday Inhalation Exposure and Systemic RO8 50<br />
9:30 AM Immunotoxicity: Mechanisms<br />
Linking the Lung and Immune<br />
System #18–23<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Monday The Development and RO6 50<br />
9:30 AM Application <strong>of</strong> Biomarkers<br />
<strong>of</strong> Toxicity #24–29<br />
Monday Dose-Additivity <strong>of</strong> Mixtures: 220 51<br />
9:30 AM Where are We Going with<br />
the Science? #30–34<br />
Monday Role <strong>of</strong> Nutrigenomics in Safety RO2 52<br />
9:30 AM Assessment <strong>of</strong> Functional<br />
Foods #35–40<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Nano Particles: General #41–45 208 52<br />
9:30 AM<br />
Monday Neurotoxicity: Pharmacological RO1 53<br />
9:30 AM and Environmental Interactions<br />
#46–52<br />
Monday Receptors: PPAR #53–59 207 54<br />
9:30 AM<br />
Poster Sessions<br />
* Attended 9:30 AM–11:00 AM; otherwise attended 11:00 AM–12:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Monday * Liver I #60–83 Exhibit Hall 54<br />
9:30 AM<br />
Monday Receptor: Ah Receptor II #84–107 Exhibit Hall 56<br />
9:30 AM<br />
Monday * Gene Expression—I #108–130 Exhibit Hall 57<br />
9:30 AM<br />
Monday Arsenic and Uranium Exhibit Hall 59<br />
9:30 AM <strong>Toxicology</strong> #131–165<br />
up-to-date information at www.toxicology.org 33
SESSION INDEX<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index (Continued)<br />
Date/Time Topic/Abstract # Room Page<br />
Monday * Immunotoxicology—Methods Exhibit Hall 61<br />
9:30 AM and Safety Evaluation #166–181<br />
Monday Signal Transduction: Kinases Exhibit Hall 62<br />
9:30 AM #182–187<br />
Monday * Methods and Devices #188–203 Exhibit Hall 63<br />
9:30 AM<br />
Monday Oxidative Stress I #204–229 Exhibit Hall 64<br />
9:30 AM<br />
Monday * Methyl Iodide Risk Exhibit Hall 65<br />
9:30 AM Assessment #230–240<br />
Monday Regulatory/Policy #241–247 Exhibit Hall 66<br />
9:30 AM<br />
Monday * Education and Public Exhibit Hall 67<br />
9:30 AM Outreach #248–251<br />
Monday Childrens Health and Juvenile Exhibit Hall 67<br />
9:30 AM Animal <strong>Toxicology</strong> #252–270<br />
Monday * Developmental Toxicity Exhibit Hall 68<br />
9:30 AM Testing #271–285<br />
Symposia<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Innovations in Toxicological RO8 70<br />
1:30 PM Sciences Session: Alternative RNA<br />
Splicing: A Mechanism for Enhancing<br />
Diversity <strong>of</strong> Gene Expresion<br />
#286–291<br />
Monday Dietary Acrylamide: New or 208 70<br />
1:30 PM Ancient Risk? #292–296<br />
Monday Environmental Factors Affecting Ballroom B 71<br />
1:30 PM Breast Cancer Susceptibility<br />
#297–302<br />
Monday The Multi-Site Ambient Particle RO4 72<br />
1:30 PM Study (MAPS): An Integrated<br />
Approach to Studying Health<br />
Effects <strong>of</strong> PM Components #303–308<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Environmental Terrorism: 220 72<br />
1:30 PM Development <strong>of</strong> Evacuation,<br />
Re–Entry and Re–Use Guidelines<br />
for Chemical, Biological and<br />
Radiological Agents #327–332<br />
Monday High Throughput Screening RO6 73<br />
1:30 PM Approaches in Genetic<br />
<strong>Toxicology</strong> #333–338<br />
Roundtable<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Electrocardiography Safety RO1 69<br />
12:15 PM Evaluation Studies—New<br />
Techniques and Approaches #339–343<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Computational <strong>Toxicology</strong>: RO1 74<br />
1:30 PM Advances and Applications<br />
#344–352<br />
Monday Biotransformation/Cytochrome RO3 74<br />
1:30 PM P450 #353–361<br />
Monday Mechanisms <strong>of</strong> Immunotoxicity RO2 75<br />
1:30 PM #362–369<br />
Poster Sessions<br />
* Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Monday * Risk Assessment I #370–408 Exhibit Hall 76<br />
1:30 PM<br />
Monday Exposure Assessment/ Exhibit Hall 78<br />
1:30 PM Epidemiology #409–432<br />
Monday * Respiratory Tract I—Pulmonary, Exhibit Hall 80<br />
1:30 PM Cardiovascular, and Immune<br />
Effects <strong>of</strong> PM #433–460<br />
Monday Pharmaceuticals–General #461–475 Exhibit Hall 82<br />
1:30 PM<br />
Monday * Safety Evaluation–Evaluation <strong>of</strong> Exhibit Hall 83<br />
1:30 PM Methods In Vitro/In Vivo #476–493<br />
Monday Biomarkers #494–540 Exhibit Hall 84<br />
1:30 PM<br />
Monday * Male Reproductive #541–558 Exhibit Hall 87<br />
1:30 PM<br />
Monday Gene Expression–II #559–579 Exhibit Hall 88<br />
1:30 PM<br />
Monday * Receptor: PPAR #580–589 Exhibit Hall 90<br />
1:30 PM<br />
Monday Neurotoxicity <strong>of</strong> Metals: Exhibit Hall 91<br />
1:30 PM Dosimetry and Effects #590–609<br />
Monday * Neurotoxicity <strong>of</strong> Metals: Exhibit Hall 92<br />
1:30 PM Mechanisms #610–634<br />
34<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index (Continued)<br />
SESSION INDEX<br />
Sunset Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Monday Brominated Flame Retardants: RO6 94<br />
4:30 PM New Findings #309–313<br />
Monday Developmental <strong>Toxicology</strong> RO8 94<br />
4:30 PM Evaluations: Issues with Including<br />
Neurotoxicology and<br />
Immunotoxicology Assessments<br />
#314–314<br />
Monday Interviewing Skills for Graduate RO2 95<br />
4:30 PM Students and Post–Docs #315–320<br />
Monday Teaching Undergraduate 220 95<br />
4:30 PM <strong>Toxicology</strong> in the 21st Century<br />
#321–326<br />
Sunrise Session<br />
Tuesday<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Toxic Torts: Toxicologists in RO1 97<br />
7:00 AM the Courtroom #635–635<br />
Symposia<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Altered Iron Homeostasis (Aih) RO2 98<br />
8:30 AM As a Basis for Pulmonary<br />
Immunotoxicologic Effects <strong>of</strong><br />
Particulate Matter #636–641<br />
Tuesday Beyond Liver Toxicognomics: 208 98<br />
8:30 AM Gene Expression Based Biomarkers<br />
in Non-Hepatic Tissues #642–647<br />
Tuesday Emerging Issues in Risk Ballroom B 99<br />
8:30 AM Assessment and Risk Perception<br />
<strong>of</strong> Nanomaterials #648–653<br />
Tuesday Nucleocytoplasmic Trafficking in RO6 100<br />
8:30 AM Mechanisms <strong>of</strong> Toxicity #654–659<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Developmental <strong>Toxicology</strong> 207 102<br />
8:30 AM #679–687<br />
Tuesday Metals <strong>Toxicology</strong> #688–696 RO8 103<br />
8:30 AM<br />
Tuesday Evaluating DNA Damage and 220 104<br />
8:30 AM Repair #697–705<br />
Poster Sessions<br />
* Attended 9:30 AM–11:00 AM; otherwise attended 11:00 AM–12:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday * Biotransformation/Cytochrome Exhibit Hall 104<br />
9:30 AM P450 I #706–740<br />
Tuesday Hepatocarcinogenesis #741–765 Exhibit Hall 107<br />
9:30 AM<br />
Tuesday * Chemical & Biological Weapons Exhibit Hall 108<br />
9:30 AM #766–796<br />
Tuesday Safety Evaluation—Biotechnology Exhibit Hall 111<br />
9:30 AM Products and Vaccines #797–812<br />
Tuesday * Signal Transduction: Oxidant Exhibit Hall 112<br />
9:30 AM Stress #813–823<br />
Tuesday Cardiovascular Disease II #824–846 Exhibit Hall 113<br />
9:30 AM<br />
Tuesday * PBPK Models #847–871 Exhibit Hall 114<br />
9:30 AM<br />
Tuesday Immunomodulation #872–913 Exhibit Hall 116<br />
9:30 AM<br />
Tuesday * Respiratory Tract II #914–947 Exhibit Hall 118<br />
9:30 AM<br />
Tuesday Reproduction and Exhibit Hall 121<br />
9:30 AM Development #948–959<br />
Tuesday * Developmental Neurotoxicity I Exhibit Hall 122<br />
9:30 AM #960–989<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Current Status and Future RO3 100<br />
8:30 AM Considerations for the Development<br />
and Validation <strong>of</strong> In Vitro<br />
Alternatives to the Draize Rabbit<br />
Eye Test #660–665<br />
Tuesday Mode <strong>of</strong> Action in Relevance <strong>of</strong> RO4 101<br />
8:30 AM Rodent Liver Tumors to Human<br />
Cancer Risk #666–672<br />
Tuesday Neuroimaging Strategies for RO1 102<br />
8:30 AM Application to Neurotoxicology<br />
and Risk Assessment #673–678<br />
up-to-date information at www.toxicology.org 35<br />
Symposia<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday The AhR in Cell Growth and RO1 126<br />
1:30 PM Death #990–995<br />
Tuesday Organophosphates & Carbmates: RO4 126<br />
1:30 PM Cholinergic vs. Noncholinergic<br />
Mechanisms #996–1001<br />
Tuesday Protemics and Antibody Ballroom B 127<br />
1:30 PM Microarrays: Applications in<br />
<strong>Toxicology</strong> #1002–1007<br />
Tuesday Update on Mechanisms for RO8 128<br />
1:30 PM Environmental Tobacco<br />
Smoke–Induced Health Effects<br />
#1008–1014
SESSION INDEX<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index (Continued)<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Current and Future Science-Based 220 128<br />
1:30 PM Approaches to Drug Evaluation:<br />
An Assessment <strong>of</strong> Potential<br />
Cancer Risk #1025–1030<br />
Tuesday Molecular Pathways to RO3 129<br />
1:30 PM Toxicant–Induced Osteoporosis<br />
#1031–1036<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday Nanoparticle Toxicity 208 130<br />
1:30 PM #1037–1045<br />
Tuesday Liver #1046–1054 RO6 130<br />
1:30 PM<br />
Poster Sessions<br />
* Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday * Developmental Neurotoxicity II Exhibit Hall 131<br />
1:30 PM #1055–1089<br />
Tuesday Nervous System: Methods and Exhibit Hall 133<br />
1:30 PM Functional Effects #1090–1107<br />
Tuesday * Female Reproductive #1108–1123 Exhibit Hall 135<br />
1:30 PM<br />
Tuesday Metals <strong>Toxicology</strong> #1124–1160 Exhibit Hall 136<br />
1:30 PM<br />
Tuesday * Gene Regulation: Metals Exhibit Hall 138<br />
1:30 PM #1161–1169<br />
Tuesday Pharmaceuticals—Methods <strong>of</strong> Exhibit Hall 139<br />
1:30 PM Evaluation #1170–1178<br />
Tuesday * Safety Evaluation–Non Exhibit Hall 139<br />
1:30 PM Pharmaceutical #1179–1190<br />
Tuesday Hypersensitivity II #1191–1214 Exhibit Hall 140<br />
1:30 PM<br />
Tuesday * Signal Transduction I #1215–1226 Exhibit Hall 142<br />
1:30 PM<br />
Tuesday Disposition/Pharmacokinetics Exhibit Hall 142<br />
1:30 PM #1227–1258<br />
Tuesday * Genetic Polymorphisms Exhibit Hall 144<br />
1:30 PM #1259–1276<br />
Tuesday Biomonitoring #1277–1291 Exhibit Hall 146<br />
1:30 PM<br />
Sunset Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Tuesday In Vitro Toxicity Testing <strong>of</strong> Air 208 150<br />
4:30 PM Pollutants: Pros and Cons<br />
#1015–1019<br />
Tuesday <strong>Toxicology</strong> Information and 220 150<br />
4:30 PM Data Update #1020–1024<br />
Symposia<br />
Wednesday<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Biomarkers <strong>of</strong> Oxidative Stress: RO4 151<br />
8:30 AM New Prospects and Approaches<br />
#1320–1325<br />
Wednesday Genetic Susceptibility and RO2 152<br />
8:30 AM Metal Toxicity #1326–1331<br />
Wednesday Pesticide Neurotoxicity in Adults: 208 152<br />
8:30 AM Integrating Contributions from<br />
Epidemiology and <strong>Toxicology</strong><br />
#1332–1337<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Current Regulatory and Scientific Ballroom B 153<br />
8:30 AM Views Regarding Chemical Hazards<br />
to Children #1338–1344<br />
Wednesday Toxicologic Evaluation <strong>of</strong> 207 153<br />
8:30 AM Inhaled Vaccines #1345–1350<br />
Wednesday Toxicological Research and Testing: RO3 154<br />
8:30 AM Best Practices and Opportunities<br />
for Laboratory Animal Refinement,<br />
Reduction, and Replacement<br />
#1351–1356<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Receptors: Ah Receptor #1357–1365 220 154<br />
8:30 AM<br />
Wednesday Female and Male Reproductive RO1 155<br />
8:30 AM Systems #1366–1374<br />
Wednesday Toxicogenomics: Role in Predictive RO6 156<br />
8:30 AM <strong>Toxicology</strong> and Carcinogenicity<br />
#1375–1383<br />
Tuesday * Statistical and Biological Exhibit Hall 147<br />
1:30 PM Models #1292–1306<br />
Tuesday Food Safety and Nutrition Exhibit Hall 149<br />
1:30 PM <strong>Toxicology</strong> II #1307–1319<br />
36<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index (Continued)<br />
SESSION INDEX<br />
Poster Sessions<br />
* Attended 9:30 AM–11:00 AM; otherwise attended 11:00 AM–12:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday * Food Safety and Nutrition Exhibit Hall 157<br />
9:30 AM <strong>Toxicology</strong> I #1384–1408<br />
Wednesday Natural Products #1409–1440 Exhibit Hall 158<br />
9:30 AM<br />
Wednesday * Respiratory Tract III #1441–1472 Exhibit Hall 161<br />
9:30 AM<br />
Wednesday Risk Assessment for Acute Exhibit Hall 163<br />
9:30 AM Inhalation Exposures #1473–1485<br />
Wednesday * Modulation <strong>of</strong> Carcinogenesis Exhibit Hall 164<br />
9:30 AM #1486–1503<br />
Wednesday Carcinogenicity Bioassays Exhibit Hall 165<br />
9:30 AM #1504–1521<br />
Wednesday * Nervous System: Mechanisms Exhibit Hall 166<br />
9:30 AM <strong>of</strong> Toxicity #1522–1553<br />
Wednesday Biotransformation/Cytochrome Exhibit Hall 168<br />
9:30 AM P450 II #1554–1581<br />
Wednesday * Ecotoxicology #1582–1598 Exhibit Hall 170<br />
9:30 AM<br />
Wednesday Cadmium and Metallothionein Exhibit Hall 171<br />
9:30 AM #1599–1619<br />
Wednesday * In Vitro #1620–1635 Exhibit Hall 172<br />
9:30 AM<br />
Wednesday Safety Evaluation—Spontaneous Exhibit Hall 174<br />
9:30 AM Disease and Control Parameters<br />
#1636–1642<br />
Symposia<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Developmental <strong>Toxicology</strong> <strong>of</strong> RO2 175<br />
1:30 PM the Lung #1643–1648<br />
Wednesday Role <strong>of</strong> Cell–Cell and Cell–Matrix RO3 176<br />
1:30 PM Interactions in Regulation <strong>of</strong><br />
Toxicant–Mediated Cell Death<br />
#1649–1653<br />
Wednesday The Ubiquitin– Proteasome System RO4 176<br />
1:30 PM as a Biological Target in Toxic<br />
Responses and Disease #1654–1658<br />
Wednesday What Makes Metals Neurotoxic Ballroom B 177<br />
1:30 PM in Neurodegenerative Disorders?<br />
#1659–1663<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Conflict <strong>of</strong> Interest #1678–1683 207 178<br />
1:30 PM<br />
Wednesday Dosimetry and Potential Impacts 220 178<br />
1:30 PM on Reproductive/Developmental<br />
Study Design and Interpretation<br />
for Risk or Safety Assessment<br />
#1684–1689<br />
Wednesday Skin Model Selection for Safety RO6 179<br />
1:30 PM Assessment <strong>of</strong> Topical Drug<br />
Products: Regulatory and Industry<br />
Perspectives #1690–1694<br />
Roundtable<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Conducting a Comprehensive RO8 175<br />
12:00 PM Toxicological and Safety Evaluation<br />
<strong>of</strong> Nanomaterials: Current<br />
Challenges and Data Needs<br />
#1695–1699<br />
Platform Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Bioinformatics: Applications to RO1 179<br />
1:30 PM <strong>Toxicology</strong> #1700–1709<br />
Wednesday Mechanisms <strong>of</strong> Hypersensitivity I 208 180<br />
1:30 PM #1710–1717<br />
Wednesday Molecular Mechanisms <strong>of</strong> RO8 181<br />
1:30 PM Oxidative Stress #1718–1726<br />
Poster Sessions<br />
* Attended 1:30 PM–3:00 PM; otherwise attended 3:00 PM–4:30 PM.<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday * Endocrine Disruptors #1727–1759 Exhibit Hall 181<br />
1:30 PM<br />
Wednesday Steroid Receptors #1760–1775 Exhibit Hall 184<br />
1:30 PM<br />
Wednesday * Pharmaceuticals–Metabolic/ Exhibit Hall 185<br />
1:30 PM Cancer #1776–1785<br />
Wednesday Mechanisms <strong>of</strong> Carcinogenesis Exhibit Hall 186<br />
1:30 PM #1786–1823<br />
Wednesday * Cardiovascular Disease I—Gene Exhibit Hall 188<br />
1:30 PM Expression #1824–1844<br />
Wednesday Oxidative Stress II #1845–1864 Exhibit Hall 190<br />
1:30 PM<br />
Wednesday * Immunotoxicology In Vitro/ Exhibit Hall 191<br />
1:30 PM Mechanisms #1865–1896<br />
Wednesday Liver II #1897–1935 Exhibit Hall 193<br />
1:30 PM<br />
up-to-date information at www.toxicology.org 37
SESSION INDEX<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Scientific Session Index (Continued)<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday * Neurotoxicity, Pesticides Exhibit Hall 196<br />
1:30 PM #1936–1967<br />
Sunset Sessions<br />
Date/Time Topic/Abstract # Room Page<br />
Wednesday Advances in Material Safety Data 207 198<br />
4:30 PM Sheet Communication #1664–1668<br />
Wednesday The Safety Assessment <strong>of</strong> 208 199<br />
4:30 PM Nutritionally Improved Food and<br />
Feed Crops #1669–1673<br />
Wednesday Vinyl Chloride: Legacy and 220 199<br />
4:30 PM Lessons Learned #1674–1677<br />
Symposia<br />
Thursday<br />
Date/Time Topic/Abstract # Room Page<br />
Thursday Cross–Species <strong>Toxicology</strong> in the RO4 200<br />
8:30 AM Age <strong>of</strong> Genomics #1968–1973<br />
Thursday Developmental Expression <strong>of</strong> 208 201<br />
8:30 AM Human Phase I and Phase II Toxicant<br />
Metabolizing Enzymes: Impact on<br />
Early Life Stage Susceptibility<br />
#1978–1984<br />
Thursday Systems Biology: Approaches and 220 201<br />
8:30 AM Applications to <strong>Toxicology</strong><br />
#1979–1984<br />
Poster Sessions<br />
* Attended 8:30 AM–10:00 AM; otherwise attended 10:00 AM–11:30 AM.<br />
Date/Time Topic/Abstract # Room Page<br />
Thursday * Alternatives to Mammalian Ballroom B 203<br />
8:30 AM Models #1996–2023<br />
Thursday Safety Evaluation—Safety Ballroom B 205<br />
8:30 AM Pharmacology #2024–2032<br />
Thursday * Persistent Organic Pollutants Ballroom B 205<br />
8:30 AM #2033–2072<br />
Thursday Risk Assessment II #2073–2112 Ballroom B 208<br />
8:30 AM<br />
Thursday * Renal <strong>Toxicology</strong> #2113–2142 Ballroom B 211<br />
8:30 AM<br />
Thursday Pesticides #2143–2170 Ballroom B 213<br />
8:30 AM<br />
Thursday * Dermal <strong>Toxicology</strong> #2171–2203 Ballroom B 215<br />
8:30 AM<br />
Thursday Genotoxicity #2204–2236 Ballroom B 217<br />
8:30 AM<br />
Thursday * Developmental <strong>Toxicology</strong> Ballroom B 219<br />
8:30 AM Mechanisms #2237–2261<br />
Thursday DNA and Protein Adducts Ballroom B 221<br />
8:30 AM #2262–2275<br />
Thursday * Apoptosis #2276–2303 Ballroom B 222<br />
8:30 AM<br />
Workshops<br />
Date/Time Topic/Abstract # Room Page<br />
Thursday Cellular/Molecular Mechanisms RO8 202<br />
8:30 AM Involved in Environmental Chemicals<br />
—Induced Dopaminergic<br />
Neurotocivity and the Consequences on<br />
Neurodegenerative Diseases #1985–1989<br />
Thursday Safety Assessment <strong>of</strong> Biological RO6 203<br />
8:30 AM Therapeutic Products—Defining<br />
the Scientific and Regulatory Issues<br />
#1990–1995<br />
38<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
The Continuing Education <strong>Program</strong> <strong>of</strong>fers a wide range <strong>of</strong> courses that cover<br />
state-<strong>of</strong>-the-art knowledge in toxicology, as well as new developments in toxicology<br />
and related disciplines. Courses can be applied toward certifying and<br />
licensing board requirements and may also be used for recertification with the<br />
American Board <strong>of</strong> <strong>Toxicology</strong> (ABT). Both basic and advanced course topics<br />
are <strong>of</strong>fered. The basic course is intended to provide a broad overview <strong>of</strong> an area<br />
or to assist individuals in learning new techniques or approaches. The advanced<br />
course is intended to be <strong>of</strong> interest to individuals with previous knowledge <strong>of</strong> the<br />
subject or already working in the field.<br />
Please Note: Each Continuing Education Course is <strong>of</strong>fered in one <strong>of</strong> three time<br />
blocks: Sunrise (7:00 AM–7:45 AM), AM (8:15 AM–12:00 NOON) or<br />
PM (1:15 PM–5:00 PM). Check the signage in the SOT registration area for<br />
room assignments.<br />
*The Primary Specialty Section (SS) or Regional Chapter (RC) Endorser<br />
FUNDAMENTALS OF NANOTECHNOLOGY: CHEMISTRY,<br />
EXPOSURE, HEALTH/ ENVIRONMENTAL ASSESSMENTS AND<br />
SOCIETAL IMPACTS<br />
SUNRISE MINI-COURSE 1<br />
BASIC<br />
Chairperson(s): David B. Warheit, DuPont Haskell Laboratory, Newark, DE.<br />
Endorsed by:<br />
Ethical Legal and Social Issues SS<br />
Inhalation SS*<br />
Occupational and Public Health SS<br />
Risk Assessment SS<br />
Nanotechnology is an emerging multidisciplinary science that deals with the<br />
creation and use <strong>of</strong> molecules a few billionths <strong>of</strong> a meter in size. Assessing the<br />
potential hazards <strong>of</strong> the nanomaterials in this technology, and the products<br />
constructed from nanoparticulates is an emerging area in toxicology and health<br />
risk assessment. The development <strong>of</strong> toxicity data sets and exposure assessments<br />
for various nanoparticles and nanomaterials is ongoing and evolving as<br />
new particles, materials and exposure methodologies are developed. A related<br />
issue in toxicology and risk assessment is the extent to which nanoparticle toxicity<br />
can be extrapolated from existing toxicology databases for macro and<br />
microscale particle-types. Additional information needs that are being<br />
addressed include the environmental and biological fate, transport, persistence,<br />
and transformation, as well as the recyclability and overall sustainability <strong>of</strong><br />
manufactured nanoparticles. This sunrise lecture is designed to be a basic<br />
primer on the fundamental chemistry and physics <strong>of</strong> engineered nanostructures.<br />
The understanding <strong>of</strong> the composition <strong>of</strong> and source generation <strong>of</strong> particles<br />
becomes fundamentally more important when one considers that the surfaces or<br />
surface coatings may comprise > 50% composition <strong>of</strong> small nanoparticles (< 30<br />
nm), and herein will lie the interactions <strong>of</strong> nanoparticles with cells. Future<br />
studies likely will demonstrate that method <strong>of</strong> particle synthesis, surface coatings,<br />
aggregation potential, surface charge, and shape may be as or more<br />
important than particle size in modifying biological/toxicological effects.<br />
Methods to form materials such as single-walled carbon nanotubes, fullerenes,<br />
quantum dots, nanocrystalline ceramics (e.g., titania), and nanometals will be<br />
reviewed. For each material class, the essential properties and applications will<br />
be outlined. The tutorial will conclude with a discussion <strong>of</strong> the actual applications<br />
<strong>of</strong> these high performance materials and projections for the industry<br />
growth over the next decade.<br />
• The Basics <strong>of</strong> Engineered Nanomaterials for Toxicologists or Tutorial:<br />
The Fundamental Chemistry and Physics <strong>of</strong> Engineered<br />
Nanostructures, Vicki L. Colvin, Rice University, Houston, TX.<br />
DOSE CONSIDERATIONS FOR IN VITRO STUDIES OF AIR<br />
POLLUTANT TOXICITY<br />
AM 02<br />
BASIC<br />
Chairperson(s): John B. Morris, University <strong>of</strong> Connecticut, Storrs, CT, and<br />
JeanClare Seagrave, Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
Endorsed by:<br />
In Vitro SS<br />
Inhalation SS*<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Technological advances have made possible the investigation <strong>of</strong> the cellular<br />
effects <strong>of</strong> air pollutants through variety <strong>of</strong> in vitro approaches. However, in order<br />
to be relevant to human health effects following ambient exposures, these<br />
methods must accurately model biologically relevant exposure pathways, doses<br />
and responses. This continuing education course will provide both theoretical<br />
and practical information on appropriate dose selection and dosage techniques<br />
for in vitro studies <strong>of</strong> air pollutant toxicity. The first presentation will cover the<br />
basic concepts <strong>of</strong> vapor dosimetry including the roles <strong>of</strong> partitioning, chemical<br />
reactivity and local metabolism. Specific information on regional respiratory<br />
deposition in laboratory animals and humans and its relevance to cellular microdosimetry<br />
will be provided. The second presentation will include specific<br />
examples <strong>of</strong> in vitro approaches with a focus on microdosimetric considerations<br />
for reactive gases; in particular the potential biological impacts <strong>of</strong> surface lining<br />
layers and their constituents will be emphasized. Basic concepts <strong>of</strong> size specific<br />
regional particle deposition and clearance will be covered in the third presentation.<br />
Specific information on regional respiratory deposition efficiencies in<br />
laboratory animals and humans and its relevance to cellular microdosimetry will<br />
be provided. The final presentation will describe specific examples <strong>of</strong> in vitro<br />
approaches on particle toxicity with a cellular dosimetric comparison <strong>of</strong> effects<br />
observed in vitro compared to those in vivo. Overall the course is aimed at<br />
providing information not only on the importance <strong>of</strong> employing in vivo dosimetric<br />
considerations in designing in vitro studies, but also with providing a<br />
firm conceptual foundation for the selection <strong>of</strong> relevant doses for such work.<br />
• Dosimetric Considerations for Vapors and Gases, John B. Morris,<br />
University <strong>of</strong> Connecticut, Storrs, CT.<br />
• In Vitro Systems for Studies <strong>of</strong> Reactive Gases, Edward Postlethwait,<br />
University <strong>of</strong> Alabama at Birmingham, Birmingham, AL.<br />
• Dosimetric Considerations for Particles, Richard B. Schlesinger, Pace<br />
University, Pleasantville, NY.<br />
• In Vitro Systems for Studies <strong>of</strong> Particles, JeanClare Seagrave, Lovelace<br />
Respiratory Research Institute, Albuquerque, NM.<br />
CE<br />
up-to-date information at www.toxicology.org 39
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
DEVELOPMENTAL TOXICOLOGY STUDIES: DESIGN,<br />
INTERPRETATION, AND RISK ASSESSMENT<br />
AM 03<br />
BASIC<br />
Chairperson(s): Joseph F. Holson, WIL Research Laboratories, Inc, Ashland,<br />
OH and Ronald D. Hood, RD Hood & Associates, <strong>Toxicology</strong> Consultants,<br />
Tuscaloosa, AL.<br />
Endorsed by:<br />
Reproductive and Developmental <strong>Toxicology</strong> SS*<br />
Risk Assessment SS<br />
Developmental toxicity studies are among the most complex and challenging in<br />
the field <strong>of</strong> toxicology. They entail multiple and interrelated endpoints and<br />
systems that are rapidly changing in characteristics and in their responses to<br />
toxic insults over time. These studies inherently generate large data sets.<br />
However, because <strong>of</strong> the decline in relevant training programs, data from developmental<br />
toxicity studies are <strong>of</strong>ten managed or interpreted by individuals with<br />
limited backgrounds in these fields. Although published regulatory agency<br />
guidance is available, this course will extend such guidance by presenting in<br />
detail current study designs, procedures for study evaluation, and case studies.<br />
Lectures will cover fetal endpoints including mortality, growth, visceral exams<br />
and skeletal exams, as well as endpoints <strong>of</strong> maternal toxicity and their relationship<br />
to developmental toxicity. Developmental toxicity will be viewed in a broad<br />
context, including aspects <strong>of</strong> postnatal development and multigenerational<br />
effects. Proper analysis <strong>of</strong> developmental toxicity data requires specific statistical<br />
considerations, and these will be presented. Finally, putting together all the<br />
data from such studies for human risk assessment will be discussed.<br />
Considerations <strong>of</strong> design flexibility, endpoint sensitivities, and use <strong>of</strong> mode <strong>of</strong><br />
action analysis and confirmatory studies will be included. Thus, the course will<br />
present key information required for understanding the biological and toxicological<br />
bases <strong>of</strong> findings from developmental toxicity studies and will provide<br />
guidance for analysis and interpretation.<br />
• Evaluation <strong>of</strong> Fetal Weight, External and Visceral Anomalies in<br />
Developmental Toxicity Studies, Donald G. Stump, WIL Research<br />
Laboratories, Inc, Ashland, OH.<br />
• Overview <strong>of</strong> Developmental Toxicity Study Designs, Endpoint<br />
Sensitivities, Statistical Power, Variability, and Use <strong>of</strong> Historical<br />
Control Data, Joseph F. Holson, WIL Research Laboratories, Inc, Ashland,<br />
OH.<br />
• Evaluation <strong>of</strong> Skeletal Endpoints in Developmental Toxicity Studies,<br />
John M. Rogers, U.S. EPA, Research Triangle Park, NC.<br />
• Use <strong>of</strong> Developmental Toxicity Data in Risk Assessment, Susan L.<br />
Makris, U.S. EPA, Washington, DC.<br />
CLINICAL PATHOLOGY—THE GRANDDADDY OF BIOMARKERS<br />
AM 04<br />
BASIC<br />
Chairperson(s): Thomas Monticello, San<strong>of</strong>i-Aventis, Bridgewater, NJ and<br />
Gail Walter, Gail Walter Consultants, Kalamazoo, MI.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Toxicologic & Exploratory Pathology SS*<br />
Research for novel biomarkers <strong>of</strong> toxicity continues to grow at a rapid pace.<br />
While biomarkers <strong>of</strong> tissue injury have a long history in the discipline <strong>of</strong> clinical<br />
pathology, the full value <strong>of</strong> these preclinical datasets are <strong>of</strong>tentimes under<br />
and/or over interpreted by scientists not extensively trained in this discipline.<br />
This basic course will emphasize current practices in clinical pathology utilized<br />
in drug discovery and preclinical safety studies and will also highlight advances<br />
in more novel biomarkers <strong>of</strong> toxicity. Basic interpretation <strong>of</strong> clinical pathology<br />
parameters will be presented in addition to factors to consider with respect to<br />
animal model, study design and the assays themselves. Examples <strong>of</strong> hepatic<br />
biomarkers and more recently identified biomarkers <strong>of</strong> toxicity will be highlighted.<br />
The applicability and pitfalls <strong>of</strong> utilizing reference ranges will be<br />
discussed, as will the approach in determining biological relevance <strong>of</strong> results<br />
versus statistical significance. Finally, regulatory perspectives on complete<br />
datasets and data interpretation will be addressed. This course is intended for the<br />
general toxicology community to improve their understanding <strong>of</strong> clinical<br />
pathology data and the role <strong>of</strong> clinical pathology in biomarker development.<br />
• Clinical Pathology Techniques in Discovery, Safety Assessment and<br />
Biomarker Development, Laurie O’Rourke, Novartis, East Hanover, NJ.<br />
• Coping with Multiple Masters: The Fine Art <strong>of</strong> Balancing Clinical<br />
Pathology and <strong>Toxicology</strong> in Preclinical Drug Development, Gail Walter,<br />
Gail Walter Consultants, Kalamazoo, MI.<br />
• Avoiding Pitfalls in the Interpretation <strong>of</strong> the Hemogram and other<br />
Clinical Pathology Assays Conducted for <strong>Toxicology</strong> Testing, Nancy<br />
Everds, Dupont Haskell Laboratory, Newark, DE.<br />
• Regulatory Perspectives on Clinical Pathology Data Analysis, Kenneth<br />
Hastings, CDER, U.S. FDA, Rockville, MD.<br />
CE<br />
40<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
IMMUNOLOGY FOR TOXICOLOGISTS<br />
AM 05<br />
BASIC<br />
Chairperson(s): Ian Kimber, Syngenta Central <strong>Toxicology</strong> Laboratory,<br />
Macclesfield,Cheshire, United Kingdom and Dori R. Germolec, National<br />
Institute for Environmental Health Sciences, Research Triangle Park, NC.<br />
Endorsed by:<br />
Immunotoxicology SS*<br />
Risk Assessment SS<br />
The adaptive immune system that is found in mammals comprises a dedicated<br />
interacting system <strong>of</strong> tissues, cells and molecules that work in concert to provide<br />
specific immune responses and host resistance to pathogenic microorganisms<br />
and transformed cells. Specific immunity is supplemented by, and works in<br />
harmony with, the phylogenetically more ancient innate immune system.<br />
Immunotoxicology describes the study <strong>of</strong> adverse health effects that may result<br />
from the interaction <strong>of</strong> xenobiotics with one or more components <strong>of</strong> the immune<br />
system. Such health effects may take a variety <strong>of</strong> forms. These include frank<br />
immunotoxicity where there is functional impairment <strong>of</strong> the immune system.<br />
The concern here is that compromised immune function may translate into an<br />
increased susceptibility to infectious and/or malignant disease. A second potential<br />
consequence <strong>of</strong> the interaction <strong>of</strong> chemicals or proteins with the immune<br />
system is allergy; defined as the adverse health effects that may arise from the<br />
stimulation <strong>of</strong> a specific immune response. Allergic disease may take a variety<br />
<strong>of</strong> forms, those <strong>of</strong> greatest significance for toxicologists being skin sensitization<br />
and allergic contact dermatitis, allergic sensitization <strong>of</strong> the respiratory tract,<br />
food allergy and idiosynctratic allergic drug reactions. Finally, xenobiotics have<br />
been implicated in the induction or exacerbation <strong>of</strong> autoimmune reactions and<br />
autoimmune disease. This course will provide a grounding in fundamental and<br />
clinical aspects <strong>of</strong> immunology, and will describe the basic elements immunotoxicity,<br />
allergy and autoimmunity. The objective is deliver an accessible guide<br />
to the immune system and immunotoxicology for general toxicologists.<br />
• An Introduction to Immunology: Fundamental and Clinical Aspects,<br />
Ian Kimber, Syngenta Central <strong>Toxicology</strong> Laboratory, Macclesfield,<br />
Cheshire, United Kingdom.<br />
• Elementary Immunotoxicology, Robert House, DynPort Vaccine<br />
Company, Frederick, MD.<br />
• Allergy and Allergic Disease, MaryJane Selgrade, U.S. EPA, Research<br />
Triangle Park, NC.<br />
• Autoimmunity and Autoimmune Disease, Dori R. Germolec, National<br />
Institute for Environmental Health Sciences, Research Triangle Park, NC.<br />
EVALUATION OF CARDIAC DRUG TOXICITY IN<br />
PHARMACEUTICAL DISCOVERY AND DEVELOPMENT<br />
AM 06 (REPEATS AS PM 12)<br />
BASIC<br />
Chairperson(s): Brian Short, Allergan, Irvine, CA and Y. J. Kang, University<br />
<strong>of</strong> Louisville, Louisville, KY.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
HESI Biomarkers Technical Committee<br />
Mechanisms SS<br />
Regulatory and Safety Evaluation SS<br />
Student Advisory Committee<br />
Toxicologic and Exploratory Pathology SS<br />
The heart is an important potential target organ to evaluate in nonclinical and<br />
clinical studies during drug development as well as a therapeutic site <strong>of</strong> action<br />
for many cardiovascular diseases. There are examples in almost every therapeutic<br />
class <strong>of</strong> drugs that produced unanticipated cardiotoxicity leading to<br />
market withdrawal or cessation <strong>of</strong> development. Toxicologists are an integral<br />
part <strong>of</strong> an interdisciplinary group, including physiologists, pharmacologists,<br />
pathologists, clinicians, and regulators, which assess cardiac safety. As such,<br />
toxicologists play a critical role in the screening <strong>of</strong> pharmaceutical agents for<br />
cardiotoxicity as well as in establishing an adequate margin <strong>of</strong> safety and<br />
working basis for monitoring therapeutic endpoints and clinical safety <strong>of</strong> trial<br />
participants. The goal <strong>of</strong> this continuing education course is to illustrate the integration<br />
<strong>of</strong> physiology, pharmacology, toxicology, and pathology <strong>of</strong> the heart<br />
addressing both recent scientific advances and practical knowledge in pharmaceutical<br />
company setting. This course will cover in vitro and in vivo models <strong>of</strong><br />
drug-induced cardiac injury and recent advances in biomarkers <strong>of</strong> cardiac injury<br />
to improve the strategy for detection and nonclinical and clinical monitoring <strong>of</strong><br />
drug-related cardiotoxicity. This CE course will provide current understanding<br />
<strong>of</strong> the physiology <strong>of</strong> the heart with a focus on normal and drug-induced disturbances<br />
in cardiac electrophysiology and cardiac function, as well as testing<br />
strategies for assessing potential cardioactive drug candidates prior to entry into<br />
clinical trials. It will also cover basic and advanced knowledge <strong>of</strong> pathology <strong>of</strong><br />
the heart, including a review <strong>of</strong> cardiac pathological evaluation, and provide<br />
case examples <strong>of</strong> the integration <strong>of</strong> physiological and pathological parameters<br />
and risk assessment to humans. Biochemical, cellular and molecular mechanisms<br />
<strong>of</strong> cardiac toxicity, including recent work in experimental animal studies<br />
and novel approaches directed toward understanding mechanisms <strong>of</strong> druginduced<br />
cardiac injury, cardiomyopathy and cardiac hypertrophy will be<br />
presented. Finally, biomarkers <strong>of</strong> drug-induced cardiac injury will be discussed.<br />
This will include a review <strong>of</strong> the findings <strong>of</strong> the Expert Working Group on<br />
Biomarkers <strong>of</strong> Drug-Induced Cardiac Toxicity, an in-depth look at serum<br />
troponins, and related work currently in progress under the ILSI-sponsored<br />
Subcommittee on the Development and Application <strong>of</strong> Biomarkers <strong>of</strong> Toxicity.<br />
• Physiological Basis for Cardiac Drug Toxicity and Evaluation, Robyn L.<br />
Phelps, Allergan, Irvine, CA.<br />
• Integrating Cardiac Pathology into Drug Discovery and Development,<br />
Calvert Louden, AstraZeneca Pharmaceuticals, Wilmington, DE.<br />
• Mechanisms <strong>of</strong> Drug-Induced Cardiotoxicity, Y. J. Kang, University <strong>of</strong><br />
Louisville, Louisville, KY.<br />
• Biomarkers <strong>of</strong> Drug-Induced Cardiac Toxicity, Malcolm J. York,<br />
GlaxoSmithKline, Ware, Hertfordshire, United Kingdom.<br />
CE<br />
up-to-date information at www.toxicology.org 41
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
INTERNATIONAL HARMONIZATION OF TECHNICAL<br />
REQUIREMENTS FOR CONDUCTING NON-CLINICAL SAFETY<br />
STUDIES OF HUMAN PHARMACEUTICALS: GUIDELINES, CASE<br />
STUDIES, AND CHALLENGES<br />
AM 07 (REPEATS AS PM 13)<br />
BASIC<br />
Chairperson(s): Rakesh Dixit, Merck Research Laboratories, West Point, PA.<br />
Endorsed by:<br />
Carcinogenesis SS*<br />
Regulatory & Safety Evaluation SS<br />
Risk Assessment SS<br />
The International Conference on Harmonization <strong>of</strong> Technical Requirements for<br />
Registration <strong>of</strong> Pharmaceuticals for Human Use (ICH) was established in 1990<br />
to standardize and harmonize technical requirements for the world-wide<br />
marketing approval <strong>of</strong> human pharmaceuticals. The six party ICH comprises the<br />
regulatory agencies and research-based pharmaceutical industrial organizations<br />
from three major geographical areas, the United States, the European Union and<br />
the Japan. The major goals <strong>of</strong> the ICH process are to minimize unique regional<br />
requirements, reduce the duplication <strong>of</strong> non-clinical toxicology and clinical<br />
testing requirements, and to accelerate the global development, registration and<br />
marketing <strong>of</strong> human pharmaceuticals in a cost-effective manner. Under Safety<br />
topics (non-clinical safety), 15 major guidelines have been harmonized and<br />
implemented through three major global regulatory agencies. These include<br />
guidelines on technical requirements for genotoxicity, toxicity, carcinogenicity,<br />
reproductive and development toxicity, biotechnology safety, toxicokinetics,<br />
safety pharmacology and joint safety and efficacy. This course is designed to<br />
provide a thorough understanding <strong>of</strong> the rationale behind ICH guidelines and<br />
the utility <strong>of</strong> the ICH guidelines in accelerating and global harmonization <strong>of</strong><br />
safety evaluation <strong>of</strong> pharmaceuticals. The presentations will also highlight case<br />
studies with detailed examples, and experience in conducting non-clinical ICH<br />
safety studies. The presentations will also discuss the challenges, and problems<br />
encountered due to the differences in the interpretation, and the acceptance <strong>of</strong><br />
the ICH Guidelines by the practicing regulatory organizations, reviewers and the<br />
traditional practices <strong>of</strong> specific geographical areas.<br />
• Guidelines on Genotoxicity Testing: Case Studies, Study Interpretation<br />
and Challenges, Sheila Galloway, Merck Research Laboratories, West<br />
Point, PA.<br />
• Developmental and Reproductive <strong>Toxicology</strong> Testing: Case Studies<br />
Study Interpretation and Challenges, Maureen Fesuton, San<strong>of</strong>i-<br />
Synthelabo, PA.<br />
• Chronic Toxicity, Carcinogenicity and Toxicokinetics Guidelines: Case<br />
Studies and Challenges, Rakesh Dixit, Merck Research Laboratories,<br />
West Point, PA.<br />
• U.S. FDA’s Experience and Guidance Related to ICH Safety<br />
Guidelines, David Jacobson-Kram, U.S. FDA, Rockville, MD.<br />
MALE REPRODUCTIVE HAZARD IDENTIFICATION AND RISK<br />
ASSESSMENT IN PHARMACEUTICAL DEVELOPMENT (WHAT DO<br />
YOU DO NOW THAT YOU HAVE A SIGNAL?)<br />
PM 08<br />
ADVANCED<br />
Chairperson(s): Michael W. Conner, Theravance, Inc., South San Francisco,<br />
CA and Robert E. Chapin, Pfizer, Inc., Groton, CT.<br />
Endorsed by:<br />
Reproductive and Developmental <strong>Toxicology</strong> SS<br />
Regulatory and Safety Evaluation SS<br />
Toxicologic & Exploratory Pathology SS<br />
In the preclinical development <strong>of</strong> pharmaceuticals, there are numerous opportunities<br />
to observe effects on the male reproductive system. There are relevant<br />
endpoints in both routine repeated-dose toxicity studies and in the developmental<br />
and reproductive toxicity studies. In recent years methods for<br />
identification <strong>of</strong> male reproductive injury have expanded well beyond the traditional<br />
endpoints <strong>of</strong> fecundity in rodent fertility studies and routine microscopic<br />
examination <strong>of</strong> testes in repeated-dose and reproductive toxicity studies. There<br />
is an expectation, for instance, that pathologists will examine testes with knowledge<br />
<strong>of</strong> and reference to the stages <strong>of</strong> the seminiferous epithelium. Assessment<br />
<strong>of</strong> number, motility and frequency <strong>of</strong> morphological abnormalities in epidydimal<br />
sperm has become routine in rodent fertility studies. Recently, some<br />
emphasis has also been placed on identification <strong>of</strong> biomarkers for testicular<br />
injury. The next steps following identification <strong>of</strong> a signal are ill defined. The<br />
purpose <strong>of</strong> this continuing education course is to address what types <strong>of</strong> signals<br />
are commonly observed and to present a rationale for interpreting these data<br />
with regard to risk assessment for volunteers and patients. The speakers in this<br />
course will place an emphasis on case studies and will provide their proposals<br />
for subsequent preclinical and/or clinical investigations. We will deal with the<br />
issue <strong>of</strong> reversible vs. irreversible injury, and review the latest data on the differences<br />
between these two. We will hear case reports on investigative mechanistic<br />
studies and when they are best pursued, and the course will close with a review<br />
<strong>of</strong> the considerations that should be addressed when risk-assessing male reproductive<br />
findings.<br />
• Early Signal Identification, Dianne Creasy, Huntingdon Life Sciences,<br />
East Millstone, NJ.<br />
• Signals in Primates—Reversible and Irreversible Injury, Kim<br />
Boekelheide, Brown University, Providence, RI.<br />
• Further Characterization <strong>of</strong> Male Reproductive Injury—Case Studies,<br />
Patrick J. Wier, GlaxoSmithKline, King <strong>of</strong> Prussia, PA.<br />
• Safety Assessment for Male Reproductive Injury, Robert E. Chapin,<br />
Pfizer, Groton, CT.<br />
CE<br />
42<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
DEVELOPMENT AND INTERPRETATION OF TOXICOKINETIC<br />
DATA FOR RISK AND SAFETY ASSESSMENT<br />
PM 09<br />
ADVANCED<br />
Chairperson(s): John Lipscomb, U.S. EPA / ORD, Cincinnati, OH and Jos<br />
Bessems, TNO, Zeist, Netherlands.<br />
Endorsed by:<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS*<br />
Student Advisory Committee<br />
Drug development and environmental health risk assessment activities are based<br />
on knowledge <strong>of</strong> chemical disposition and tissue interactions, that may be separately<br />
considered as toxicokinetics (TK) and toxicodynamics (TD). Each<br />
activity is initiated with valuation <strong>of</strong> basic toxicity information, including characterizing<br />
effective doses and the dose-response relationship identifying critical<br />
organs, tissues and processes; examining metabolic characteristics and the toxic<br />
nature <strong>of</strong> metabolites. Each activity culminates with the assessment <strong>of</strong> TK and<br />
TD relative to the concentration/dose-response relationship. This basic continuing<br />
education course is intended for the general toxicologist desiring to<br />
increase the use <strong>of</strong> TK data to build compound dossiers, and to address the<br />
needs <strong>of</strong> scientists designing toxicity and pharmacokinetic studies, preclinical<br />
and clinical studies, and conducting safety and/or risk assessments. Four<br />
lectures will be presented; content will address the design, conduct and evaluation<br />
<strong>of</strong> studies to inform an understanding <strong>of</strong> chemical disposition and<br />
effectiveness in the biological system. Instruction will be given on the considerations<br />
<strong>of</strong> doses and concentrations used in whole-animal toxicity and ADME<br />
studies and in in vitro investigations; the biochemical basis <strong>of</strong> chemical metabolism<br />
and the considerations and assumptions necessary to interpret metabolism<br />
findings; best use <strong>of</strong> TK data to inform doses intended for use in TD studies;<br />
extrapolations <strong>of</strong> effective doses between and among species through the use <strong>of</strong><br />
default and chemical-specific uncertainty/adjustment factors; available guidance<br />
on uncertainty factor derivation for human health risk assessment;<br />
overview <strong>of</strong> PBPK modeling and its application to extrapolations <strong>of</strong> dose, route<br />
and duration, between and among species; and the basis and results <strong>of</strong> choice <strong>of</strong><br />
classical or PBPK modeling for drug development and risk assessment.<br />
• Use <strong>of</strong> ADME Data in Toxicity Study Design, Jos Bessems, TNO, Zeist,<br />
Netherlands.<br />
• Combining Toxicokinetic and Toxicodynamic Data for Application in<br />
Drug Development, Rakesh Dixit, Merck Research Laboratories, West<br />
Point, PA.<br />
• Use <strong>of</strong> Compound Specific and General Kinetic Data in Human Risk<br />
Assessment, John Lipscomb, U.S. EPA / ORD, Cincinnati, OH.<br />
• Physiologically Based Pharmacokinetic Modeling, Hugh Barton,<br />
Research Triangle Park, NC.<br />
PHOTOTOXICITY: CURRENT CONCEPTS, EXPERIMENTAL<br />
DESIGNS, AND REGULATORY EXPECTATIONS<br />
PM 10<br />
BASIC<br />
Chairperson(s): Joseph Tigner, Purdue Pharma L.P., Ardsley, NY and Vincent<br />
A. Murphy, P&G Pharmaceuticals, Inc., Cincinnati, OH.<br />
Endorsed by:<br />
Regulatory and Safety Evaluation SS*<br />
Risk Assessment SS<br />
Exposure to solar ultraviolet and visible radiation produces acute and chronic<br />
skin damage. Chemicals, including pharmaceutical agents, may exacerbate such<br />
effects following topical or systemic exposure. The aim <strong>of</strong> phototoxicological<br />
testing is to predict the likelihood <strong>of</strong> such events using various in vivo and in<br />
vitro models. The purpose <strong>of</strong> this course is to familiarize toxicologists with the<br />
basic concepts <strong>of</strong> phototoxicological testing. This is especially important in light<br />
<strong>of</strong> recent U.S. and European regulatory guidances relating to photosafety<br />
testing. The program will describe the comparative anatomy, physiology, and<br />
basic photobiology <strong>of</strong> the skin, the basic principles and experimental designs<br />
used in phototoxicity testing in nonclinical species and people as well as in vitro<br />
models. The course will also address the most recent regulatory guideline from<br />
the U.S. FDA regarding phototoxicity testing.<br />
• Effect <strong>of</strong> Light on the Structure and Function <strong>of</strong> Skin, J.F. Nash, The<br />
Procter & Gamble Co., Cincinnati, OH.<br />
• Phototoxicity, Photocarcinogenicity, and Photoallergy. Study Designs<br />
and Issues, P. Donald Forbes, Argus Research-Charles River, Horsham,<br />
PA.<br />
• Drug Phototoxicity in Humans: A Randomized Controlled Trial<br />
Methodology, James Ferguson, Dundee, Scotland.<br />
• CDER/FDA Photosafety Guidance for Industry, Abigail Jacobs, U.S.<br />
FDA/CDER, Rockville, MD.<br />
CE<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
SOMETHING OLD, SOMETHING NEW; TRADITIONAL AND NOVEL<br />
BIOMARKERS OF RENAL INJURY<br />
PM 11<br />
BASIC<br />
Chairperson(s): Susan Emeigh Hart, AstraZeneca Pharmaceuticals,<br />
Wilmington, DE and Syril Pettit, ILSI Health and Environmental Sciences<br />
Institute (HESI), Washington, DC.<br />
Endorsed by:<br />
Risk Assessment SS<br />
Toxicologic & Exploratory Pathology SS*<br />
Because the kidney is an important target organ <strong>of</strong> toxicity, there is a need for<br />
sensitive, specific and non-invasive assays that can be used to detect low-level,<br />
potentially reversible renal injury in both animal toxicology studies and the clinical<br />
setting. Most <strong>of</strong> the available techniques do not allow identification <strong>of</strong> the<br />
segment(s) <strong>of</strong> the kidney affected by a toxicant. Better understanding <strong>of</strong> the<br />
pathophysiology <strong>of</strong> nephrotoxic processes, combined with information arising<br />
from genomic, proteomic and molecular biologic assessment <strong>of</strong> the effects <strong>of</strong><br />
nephrotoxic chemicals has led to the identification <strong>of</strong> several promising new<br />
candidates that might serve as sensitive, segment-selective biomarkers <strong>of</strong><br />
nephrotoxicity that can be applied readily in both the preclinical and clinical<br />
settings with adequate testing and validation. This basic CE course will provide<br />
an overview <strong>of</strong> renal structure and function, discuss the appropriate use and<br />
limitations <strong>of</strong> traditional clinical pathology assessment <strong>of</strong> renal injury, and<br />
describe the processes necessary for appropriate validation and subsequent<br />
regulatory acceptance <strong>of</strong> a novel biomarker. The final two speakers will describe<br />
the novel biomarker candidates under consideration by the Nephrotoxicity<br />
Working Group <strong>of</strong> the ILSI-HESI Technical Committee on the Development and<br />
Application <strong>of</strong> Biomarkers <strong>of</strong> Toxicity. The first <strong>of</strong> these will provide an<br />
overview <strong>of</strong> novel biomarkers for proximal tubular injury while the second will<br />
discuss the pathophysiology <strong>of</strong> renal papillary necrosis and how it relates to the<br />
identification <strong>of</strong> novel biomarkers <strong>of</strong> papillary injury.<br />
• Technical and Regulatory Issues in Biomarker Selection and<br />
Validation, James T. MacGregor, <strong>Toxicology</strong> Consulting Services, Arnold,<br />
MD.<br />
• Classical Clinical Pathology Approaches to the Assessment <strong>of</strong> Renal<br />
Structure and Function, Denise Bounous, Bristol-Meyers Squibb<br />
Company, Princeton, NJ.<br />
• Emerging Biomarkers <strong>of</strong> Renal Proximal Tubular Injury, Ernie Harpur,<br />
San<strong>of</strong>i-Synthelabo Research, Malvern, PA.<br />
• Emerging Biomarkers <strong>of</strong> Renal Papillary Necrosis, Susan Emeigh Hart,<br />
AstraZeneca Pharmaceuticals, Wilmington, DE.<br />
EVALUATION OF CARDIAC DRUG TOXICITY IN<br />
PHARMACEUTICAL DISCOVERY AND DEVELOPMENT<br />
PM 12 (REPEATS AS AM 06)<br />
BASIC<br />
Chairperson(s): Brian Short, Allergan, Irvine, CA and Y. J. Kang, University<br />
<strong>of</strong> Louisville, Louisville, KY.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
HESI Biomarkers Technical Committee<br />
Mechanisms SS<br />
Regulatory and Safety Evaluation SS<br />
Student Advisory Committee<br />
The heart is an important potential target organ to evaluate in nonclinical and<br />
clinical studies during drug development as well as a therapeutic site <strong>of</strong> action<br />
for many cardiovascular diseases. There are examples in almost every therapeutic<br />
class <strong>of</strong> drugs that produced unanticipated cardiotoxicity leading to<br />
market withdrawal or cessation <strong>of</strong> development. Toxicologists are an integral<br />
part <strong>of</strong> an interdisciplinary group, including physiologists, pharmacologists,<br />
pathologists, clinicians, and regulators, which assess cardiac safety. As such,<br />
toxicologists play a critical role in the screening <strong>of</strong> pharmaceutical agents for<br />
cardiotoxicity as well as in establishing an adequate margin <strong>of</strong> safety and<br />
working basis for monitoring therapeutic endpoints and clinical safety <strong>of</strong> trial<br />
participants. The goal <strong>of</strong> this continuing education course is to illustrate the integration<br />
<strong>of</strong> physiology, pharmacology, toxicology, and pathology <strong>of</strong> the heart<br />
addressing both recent scientific advances and practical knowledge in pharmaceutical<br />
company setting. This course will cover in vitro and in vivo models <strong>of</strong><br />
drug-induced cardiac injury and recent advances in biomarkers <strong>of</strong> cardiac injury<br />
to improve the strategy for detection and nonclinical and clinical monitoring <strong>of</strong><br />
drug-related cardiotoxicity. This CE course will provide current understanding<br />
<strong>of</strong> the physiology <strong>of</strong> the heart with a focus on normal and drug-induced disturbances<br />
in cardiac electrophysiology and cardiac function, as well as testing<br />
strategies for assessing potential cardioactive drug candidates prior to entry into<br />
clinical trials. It will also cover basic and advanced knowledge <strong>of</strong> pathology <strong>of</strong><br />
the heart, including a review <strong>of</strong> cardiac pathological evaluation, and provide<br />
case examples <strong>of</strong> the integration <strong>of</strong> physiological and pathological parameters<br />
and risk assessment to humans. Biochemical, cellular and molecular mechanisms<br />
<strong>of</strong> cardiac toxicity, including recent work in experimental animal studies<br />
and novel approaches directed toward understanding mechanisms <strong>of</strong> druginduced<br />
cardiac injury, cardiomyopathy and cardiac hypertrophy will be<br />
presented. Finally, biomarkers <strong>of</strong> drug-induced cardiac injury will be discussed.<br />
This will include a review <strong>of</strong> the findings <strong>of</strong> the Expert Working Group on<br />
Biomarkers <strong>of</strong> Drug-Induced Cardiac Toxicity, an in-depth look at serum<br />
troponins, and related work currently in progress under the ILSI-sponsored<br />
Subcommittee on the Development and Application <strong>of</strong> Biomarkers <strong>of</strong> Toxicity.<br />
• Physiological Basis for Cardiac Drug Toxicity and Evaluation, Robyn L.<br />
Phelps, Allergan, Irvine, CA.<br />
• Integrating Cardiac Pathology into Drug Discovery and Development,<br />
Calvert Louden, AstraZeneca Pharmaceuticals, Wilmington, DE.<br />
• Mechanisms <strong>of</strong> Drug-Induced Cardiotoxicity, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
• Biomarkers <strong>of</strong> Drug-Induced Cardiac Toxicity, Malcolm J. York,<br />
GlaxoSmithKline, Ware, Hertfordshire, United Kingdom.<br />
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44<br />
SOT’s 44 th Annual Meeting
INTERNATIONAL HARMONIZATION OF TECHNICAL<br />
REQUIREMENTS FOR CONDUCTING NON-CLINICAL SAFETY<br />
STUDIES OF HUMAN PHARMACEUTICALS: GUIDELINES, CASE<br />
STUDIES, AND CHALLENGES<br />
PM 13 (REPEATS AS AM 07)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Continuing Education<br />
BASIC<br />
Chairperson(s): Rakesh Dixit, Merck Research Laboratories, West Point, PA.<br />
The International Conference on Harmonization <strong>of</strong> Technical Requirements for<br />
Registration <strong>of</strong> Pharmaceuticals for Human Use (ICH) was established in 1990<br />
to standardize and harmonize technical requirements for the world-wide<br />
marketing approval <strong>of</strong> human pharmaceuticals. The six party ICH comprises the<br />
regulatory agencies and research-based pharmaceutical industrial organizations<br />
from three major geographical areas, the United States, the European Union and<br />
the Japan. The major goals <strong>of</strong> the ICH process are to minimize unique regional<br />
requirements, reduce the duplication <strong>of</strong> non-clinical toxicology and clinical<br />
testing requirements, and to accelerate the global development, registration and<br />
marketing <strong>of</strong> human pharmaceuticals in a cost-effective manner. Under Safety<br />
topics (non-clinical safety), 15 major guidelines have been harmonized and<br />
implemented through three major global regulatory agencies. These include<br />
guidelines on technical requirements for genotoxicity, toxicity, carcinogenicity,<br />
reproductive and development toxicity, biotechnology safety, toxicokinetics,<br />
safety pharmacology and joint safety and efficacy. This course is designed to<br />
provide a thorough understanding <strong>of</strong> the rationale behind ICH guidelines and<br />
the utility <strong>of</strong> the ICH guidelines in accelerating and global harmonization <strong>of</strong><br />
safety evaluation <strong>of</strong> pharmaceuticals. The presentations will also highlight case<br />
studies with detailed examples, and experience in conducting non-clinical ICH<br />
safety studies. The presentations will also discuss the challenges, and problems<br />
encountered due to the differences in the interpretation, and the acceptance <strong>of</strong><br />
the ICH Guidelines by the practicing regulatory organizations, reviewers and the<br />
traditional practices <strong>of</strong> specific geographical areas.<br />
• Guidelines on Genotoxicity Testing: Case Studies, Study Interpretation<br />
and Challenges, Sheila Galloway, Merck Research Laboratories, West<br />
Point, PA.<br />
• Developmental and Reproductive <strong>Toxicology</strong> Testing: Case Studies<br />
Study Interpretation and Challenges, Maureen Fesuton, San<strong>of</strong>i-<br />
Synthelabo, PA.<br />
• Chronic Toxicity, Carcinogenicity and Toxicokinetics Guidelines: Case<br />
Studies and Challenges, Rakesh Dixit, Merck Research Laboratories,<br />
West Point, PA.<br />
• U.S. FDA’s Experience and Guidance Related to ICH Safety<br />
Guidelines, David Jacobson-Kram, U.S. FDA, Rockville, MD.<br />
CE<br />
up-to-date information at www.toxicology.org 45
44 th Annual Meeting<br />
and ToxExpo<br />
Notes:<br />
CE<br />
46<br />
SOT’s 44 th Annual Meeting
Saturday Afternoon, March 5<br />
2:00 PM to 5:00 PM<br />
Room 211<br />
COMMITTEE CHAIR ORIENTATION<br />
If you will be a Committee Chairperson in 2005–2006, please make plans to<br />
attend the Committee Chairperson Meeting scheduled for 2:00 PM–5:00 PM,<br />
Saturday, March, 5. With new committee assignments taking effect on May 1,<br />
2005, the meeting is intended to provide new (and current, if desired) chairpersons<br />
with a basic tutorial on the SOT structure, operation, and strategic<br />
direction. For additional information, please contact SOT Headquarters.<br />
Saturday Afternoon, March 5<br />
5:00 PM to 7:00 PM<br />
Sheraton Hotel, Napoleon D1<br />
CRAD SEMINAR: CAREER MOVE: AN AMALGAM OF<br />
OPPORTUNITIES AND UNCERTAINTIES<br />
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Scientific Sessions and Special Events will be held at the Ernest N. Morial Convention Center unless otherwise listed.<br />
Saturday Afternoon, March, 5<br />
6:15 PM to 9:00 PM<br />
Sheraton Hotel, Oak Alley<br />
UNDERGRADUATE EDUCATION PROGRAM FOR MINORITY<br />
STUDENTS<br />
Chairperson(s): Rosita Proteau, SCMI Chair, Oregon State University,<br />
Corvallis, OR and Alice Villalobos, University <strong>of</strong> Rochester, Rochester, NY.<br />
Sponsored by:<br />
Education Committee<br />
Education Subcommittee for Minority Initiatives<br />
The objective <strong>of</strong> this program is to introduce minority undergraduate students<br />
and their advisors to toxicology and to encourage preparation for graduate study<br />
and pursuit <strong>of</strong> careers in the discipline. The opening session will provide an<br />
introduction to toxicology and promote interaction <strong>of</strong> the students with their<br />
peers, students who had participated in the program in the past, and SOT toxicologist<br />
hosts.<br />
SATURDAY / SUNDAY<br />
Chairperson(s): Mitzi Nagarkatti, Virginia Commonwealth University,<br />
Richmond, VA and Julia Kimbell, CIIT Centers for Health Research, Research<br />
Triangle Park, NC.<br />
Endorsed by:<br />
Career Resource and Development Committee (formerly Placement<br />
Committee)<br />
Education Committee<br />
Women in <strong>Toxicology</strong> SS<br />
This workshop is targeted to those seeking career advancement opportunities<br />
including graduate students, post-doctoral trainees as well as entry-level, midcareer<br />
and established pr<strong>of</strong>essionals in all employment sectors for toxicologists.<br />
The session will address the major issues that are faced particularly prior to job<br />
seeking such as marketing one-self, critical decision-making and negotiating<br />
<strong>of</strong>fers. Emphasis will also be placed on the challenges and angst involved in<br />
change <strong>of</strong> scientific career paths across academia, government, industry,<br />
contract jobs and consultancy.<br />
In the first part <strong>of</strong> the session, the types <strong>of</strong> post-doctoral opportunities available<br />
and funding resources for such mentored training will be presented. If one<br />
accepts a job without undertaking post-doctoral training, how to update one’s<br />
pr<strong>of</strong>essional skills will also be addressed. The latter part <strong>of</strong> the session will deal<br />
with the details involved in accepting the first independent investigator position<br />
as well as what is involved in moving from academia to non-academic positions<br />
and vice versa.<br />
• Time <strong>of</strong> Angst: What to Look for in Seeking Post-Doctoral Training,<br />
MaryJane Selgrade, EPA, Research Triangle Park, NC.<br />
• To Be or Not to Be: Is Post-Doctoral Training Essential for Non-<br />
Academic Positions?, Justin Teeguarden, Pacific Northwest National<br />
Laboratories, Richland, WA.<br />
• Welcome to the Academic World: Moving Up the Academic Ladder,<br />
Norbert Kaminski, Michigan State University, East Lansing, MI.<br />
• Back to the Grind: Facing Challenges <strong>of</strong> Transition from Non-<br />
Academic to Academic, Raymond Yang, Colorado State University, Fort<br />
Collins, CO.<br />
• Moving to Different Pastures: Adapting to Job Switch from Academia<br />
to a Non-Academic Position, Myrtle Davis, Eli Lilly & Company,<br />
Greenfield, IN.<br />
5:30 PM–6:00 PM Orientation for SOT Hosts, Peer Mentors, and<br />
Advisors<br />
6:00 PM–6:15 PM Registration for Students<br />
6:15 PM–7:00 PM Opening Event<br />
7:15 PM Dinner<br />
7:45 PM–8:30 PM Opening Lecture: What is <strong>Toxicology</strong>?<br />
Craig Marcus, University <strong>of</strong> New Mexico,<br />
Albuquerque, NM.<br />
8:30 PM–9:00 PM Dessert and Networking<br />
Sunday Morning, March 6<br />
8:00 AM to 5:00 PM<br />
Room 213<br />
Sunday<br />
UNDERGRADUATE EDUCATION PROGRAM<br />
Chairperson(s): Rosita Proteau, SCMI Chair, Oregon State University,<br />
Corvallis, OR and Alice Villalobos, University <strong>of</strong> Rochester, Rochester, NY.<br />
Sponsored by:<br />
Education Committee<br />
Education Subcommittee for Minority Initiatives<br />
A series <strong>of</strong> special introductory toxicology lectures will be presented to undergraduate<br />
students registered for this program, including the participants in the<br />
Undergraduate Minority Education <strong>Program</strong> for Minority Students. This will be<br />
followed by sessions providing information for successful application to graduate<br />
school, and the opportunity to meet with directors <strong>of</strong> academic toxicology<br />
programs and internship sponsors. The goal is to encourage undergraduate<br />
students to prepare for graduate study and pursuit <strong>of</strong> careers in toxicology.<br />
8:00 AM Introductions and Special <strong>Toxicology</strong> Lectures I<br />
8:15 AM–8:45 AM Nanotechnology and Related <strong>Toxicology</strong><br />
up-to-date information at www.toxicology.org 47
SATURDAY / SUNDAY<br />
8:45 AM–9:15 AM Forensic <strong>Toxicology</strong><br />
Martin Philbert, University <strong>of</strong> Michigan, Ann<br />
Arbor, MI.<br />
William J. George, Tulane University School <strong>of</strong><br />
Medicine, New Orleans, LA.<br />
9:15 AM–9:45 AM Break and Discussion at Poster Boards with First<br />
Speakers<br />
Special <strong>Toxicology</strong> Lectures II<br />
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Mary Ann Smith, University <strong>of</strong> Texas School <strong>of</strong><br />
Public Health, Houston, TX.<br />
2:00 PM–2:40 PM Mentoring Diverse Undergraduates<br />
All Participants<br />
Antonio Baines, University <strong>of</strong> North Carolina-<br />
Chapel Hill, NC.<br />
3:00 PM–5:00 PM Open Time with Academic <strong>Toxicology</strong> <strong>Program</strong><br />
Directors and Internship Sponsors<br />
9:45 AM–10:15 AM Contaminants, Endocrine Disruption, and<br />
Wildlife: Lessons from the Swamp<br />
10:15 AM–10:30 AM TBA<br />
Lou Guillette, University <strong>of</strong> Florida, Gainesville,<br />
FL.<br />
Speaker TBA<br />
Interactive Session<br />
10:30 AM–11:30 AM Effects <strong>of</strong> TCDD on Mammary Glands and<br />
Lactation<br />
B. Paige Lawrence, Washington State University,<br />
Pullman, WA.<br />
11:30 AM–12:30 PM Lunch and Discussion at Poster Boards<br />
For Students<br />
12:30 PM–2:45 PM Break out Sessions, 40-minute concurrent<br />
sessions, each repeated three times<br />
(12:30 PM–1:10 PM, 1:15 PM–1:55 PM,<br />
2:00 PM–2:40 PM)<br />
A) What is Graduate School and What Can I<br />
Expect?<br />
Damani Parran, Virginia/Maryland Regional<br />
College <strong>of</strong> Veterinary Medicine, Blacksburg, VA.<br />
Adrian Nanez, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
B) An Academic Advisor’s Perspective on How to<br />
Get into Graduate School<br />
Heather Kleiner, Lousiana State University,<br />
Shreveport, LA.<br />
C) What Do I Say? Suggestions for Discussion<br />
with <strong>Program</strong> Directors, Internship Hosts, Poster<br />
Presenters<br />
Sunday Evening, March 6<br />
5:15 PM to 6:30 PM<br />
Room 220<br />
AWARDS PRESENTATION<br />
Join the <strong>Society</strong> in recognizing and honoring distinguished toxicologists as they<br />
receive prestigious awards at the SOT Awards Presentation.<br />
Sunday Evening, March 6<br />
6:30 PM to 7:30 PM<br />
La Louisiane Ballroom<br />
WELCOMING RECEPTION<br />
Join us on Sunday, March 6, 2005, as SOT kicks-<strong>of</strong>f its 44th Annual Meeting.<br />
This will be a memorable evening <strong>of</strong> reminiscing with friends, good fun, and<br />
looking to the future <strong>of</strong> SOT. Please join the <strong>Society</strong> in this inaugural event <strong>of</strong><br />
the Annual Meeting. Enjoy complimentary hors d’oeuvres; a cash bar will be<br />
available.<br />
Sunday Evening, March 6<br />
7:00 PM to 8:00 PM<br />
Room 215<br />
25-YEAR (OR MORE) MEMBER RECEPTION<br />
Have you been a member <strong>of</strong> the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> for 25 years (or more)?<br />
If so, please consider joining your colleagues in celebration and recognition <strong>of</strong><br />
the scientists who established the <strong>Society</strong>.<br />
Sunday Evening, March 6<br />
7:30 PM to 8:30 PM<br />
Hilton Riverside, Grand Ballroom A<br />
STUDENT/POST-DOCTORAL FELLOW MIXER<br />
All students and post-docs are invited to network at this fun-filled reception.<br />
Refreshments will be provided by SOT and sponsors — a cash bar will also be<br />
available. Meeting Badges and tickets are required.<br />
Vicente Santa Cruz, Chevron Phillips Chemical<br />
Company LP, Woodlands, TX.<br />
For Advisors<br />
12:30 PM–1:10 PM Tips for Advising Prospective Graduate Students<br />
Rick Schnellmann, Medical University <strong>of</strong> South<br />
Carolina, Charleston, SC.<br />
1:15 PM–1:55 PM An Admissions Committee Perspective on Student<br />
Diversity<br />
48<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Monday Morning<br />
Monday Morning, March 7<br />
9:30 AM to 11:30 AM<br />
Exhibit Hall A<br />
Monday Morning, March 7<br />
7:30 AM to 3:00 PM<br />
Room 214<br />
UNDERGRADUATE EDUCATION PROGRAM FOR MINORITY<br />
STUDENTS<br />
Chairperson(s): Rosita Proteau, SCMI Chair, Oregon State University,<br />
Corvallis, OR.<br />
Sponsored by:<br />
Education Committee<br />
Education Subcommittee for Minority Initiatives<br />
7:30 AM–8:00 AM Breakfast for Students, Advisors, Peer Mentors,<br />
and SOT Hosts<br />
8:15 AM–9:15 AM Plenary Lecture: Science, Policy, and Regulation<br />
at the White House Office <strong>of</strong> Information and<br />
Regulatory Affairs, John D. Graham, Office <strong>of</strong><br />
Information and Regulatory Affairs, OIRA<br />
9:30 AM–11:30 AM Special Poster Session for Visiting Students<br />
POSTER SESSION FOR VISITING STUDENTS<br />
Chairperson(s): Rosita Proteau, SCMI Chair, Oregon State University,<br />
Corvallis, OR and Javier Avalos, TopTox, Sacramento, CA.<br />
Sponsored by:<br />
Education Committee<br />
Education Subcommittee for Minority Initiatives<br />
This poster session is part <strong>of</strong> the Undergraduate Education <strong>Program</strong> for<br />
Minority Students. All are welcome to view the specially selected presentations<br />
which provide an overview <strong>of</strong> research in toxicology and demonstrate the diversity<br />
within the discipline.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room RO4<br />
SYMPOSIUM SESSION: THE FUTURE OF MOLECULAR GENETIC<br />
THERAPEUTICS<br />
Chairperson(s): David Monteith, Lilly Research Laboratories, Greenfield, IN<br />
and Vijay Reddy, Lilly Research Laboratories, Greenfield, IN.<br />
MONDAY<br />
11:45 AM–1:00 PM Closing Session<br />
1:00 PM–3:00 PM Evaluation Focus Groups<br />
Monday Morning, March 7<br />
8:30 AM to 9:15 AM<br />
La Louisiane Ballroom<br />
PLENARY LECTURE: SCIENCE, POLICY, AND REGULATION AT<br />
THE WHITE HOUSE OFFICE OF INFORMATION AND<br />
REGULATORY AFFAIRS<br />
Lecturer: John D. Graham, Administrator, Office <strong>of</strong> Management and Budget,<br />
OIRA.<br />
John D. Graham, PhD, is Administrator <strong>of</strong> the Office <strong>of</strong> Information and<br />
Regulatory Affairs within the White House Office <strong>of</strong> Management and Budget.<br />
As OIRA Administrator, Dr. Graham has pursued an agenda <strong>of</strong> “smarter regulation.”<br />
This means that the <strong>of</strong>fice is neither pro-regulation nor anti-regulation.<br />
OIRA seeks to accelerate the adoption <strong>of</strong> sensible rules, modify existing rules<br />
to make them more effective and less costly, and rescind outdated rules whose<br />
benefits do not justify their costs. Under Dr. Graham’s leadership, OIRA has<br />
made changes in many areas to increase the reliance on sound science. These<br />
initiatives include government-wide Information Quality Guidelines, guidance<br />
on Peer Review, and a revised circular on Regulatory Analysis for benefits and<br />
costs <strong>of</strong> regulations. Dr. Graham will talk about these initiatives, other OIRA<br />
activities, and also share with SOT ways in which members <strong>of</strong> the public can<br />
constructively engage in the process <strong>of</strong> bringing sound science to the policy<br />
arena.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
Regulatory and Safety Evaluation SS*<br />
Student Advisory Committee<br />
During the last decade the decoding <strong>of</strong> the human genome has provided exciting<br />
possibilities for the treatment <strong>of</strong> human disease. The promise <strong>of</strong> gene therapy<br />
and antisense have stirred the imagination to the potential <strong>of</strong> redirecting<br />
abnormal cellular processes. These therapies provide potential advantages in<br />
specificity to gene targets and selectivity for protein intervention in some<br />
disease targets that are <strong>of</strong>ten considered ‘undruggable’ with traditional<br />
chemotherapies. To date, these technologies have provided interesting technologies<br />
as research tools to gain perspective with respect to effects <strong>of</strong> various<br />
targets; in particular antisense strategies using single-strand and siRNA provide<br />
tools to validate molecular targets in disease pathways. These antisense<br />
approaches utilize different mechanisms (i.e., RISK complex and RNase H) to<br />
reduce a target protein in a manner not achievable with a small molecule<br />
approach. Gene therapy has posed the potential to treat and possibly cure disease<br />
by replacing lost function with the insertion <strong>of</strong> a normal gene. Currently, there<br />
are numerous antisense and gene therapy clinical candidates in development by<br />
corporate sponsors as well as academic centers and investigators. The selection<br />
<strong>of</strong> disease candidates and targets is complex. The administration, delivery, cell<br />
permeability, and pharmacokinetic and pharmacodynamic attributes have<br />
played a critical role in the development <strong>of</strong> these therapies. This symposium will<br />
cover the biologic and safety hurdles these therapies have faced and the solutions<br />
that have been developed to evaluate these molecules in patients. The<br />
symposium will consist <strong>of</strong> an expert panel <strong>of</strong> presenters involved in the science<br />
and development issues surrounding molecular genetic therapies.<br />
#13 9:30 THE FUTURE OF MOLECULAR GENETIC<br />
THERAPEUTICS. D. Monteith and V. Reddy. Eli Lilly<br />
and Company, Greenfield, IN.<br />
#14 9:40 GENE THERAPY: A SIMPLE CONCEPT WITH<br />
COMPLEX CHALLENGES. R. M. Lyons. Self-<br />
Employed, Gaithersburg, MD.<br />
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MONDAY<br />
#15 10:15 DEVELOPMENT OF SHORT INTERFERING<br />
RNAS (SIRNAS) AS POTENTIAL<br />
THERAPEUTICS. P. A. Pavco. Development, Sirna<br />
Therapeutics, Inc., Boulder, CO. Sponsor: J. Lockridge.<br />
#16 10:50 ANTISENSE THERAPEUTICS: PROGRESS IN<br />
THE DEVELOPMENT OF A NOVEL<br />
THERAPEUTIC PLATFORM. S. P. Henry and A. A.<br />
Levin. <strong>Toxicology</strong>, Isis Pharmaceuticals, Carlsbad, CA.<br />
#17 11:25 CLINICAL CONSIDERATIONS IN THE<br />
DEVELOPMENT OF MOLECULAR THERAPIES<br />
FOR CANCER. M. F. Burgess. Lilly Research Centre,<br />
Windlesham, Surrey, United Kingdom. Sponsor: D.<br />
Monteith.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room RO8<br />
SYMPOSIUM SESSION: INHALATION EXPOSURE AND SYSTEMIC<br />
IMMUNOTOXICITY: MECHANISMS LINKING THE LUNG AND<br />
IMMUNE SYSTEM<br />
Chairperson(s): MaryJane Selgrade, U.S. EPA, Research Triangle Park, NC<br />
and Judy T. Zelik<strong>of</strong>f, New York University, Environmental Medicine, New York,<br />
NY.<br />
#20 10:05 IMMUNOTOXICITY OF AEROSOLIZED JP-8<br />
JET FUEL EXPOSURE AND ITS PREVENTION<br />
BY SUBSTANCE P. D. T. Harris 1 and M. Witten 2 .<br />
1 Microbiology & Immunology, University <strong>of</strong> Arizona,<br />
Tucson, AZ and 2 Pediatrics, University <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
#21 10:35 IMMUNOTOXICITY OF SARIN AND OTHER<br />
CHOLINERGIC AGENTS. M. Sopori, R. Kalra, R.<br />
Langley, S. Razani-Boroujerdi, N. Mishra and R.<br />
Henderson. Immunology, Lovelace Respiratory<br />
Research Institute, Albuquerque, NM.<br />
#22 11:05 PRENATAL EXPOSURE OF MICE TO<br />
CIGARETTE SMOKE ALTERS TUMOR<br />
SURVEILLANCE MECHANISM(S) IN THE<br />
JUVENILE AND ADULT OFFSPRING. J. T. Zelik<strong>of</strong>f<br />
and S. P. Ng. Nelson Institute <strong>of</strong> Environmental<br />
Medicine, School <strong>of</strong> Medicine, New York University,<br />
Tuxedo, NY.<br />
#23 11:35 COMPARATIVE INHALATION<br />
IMMUNOTOXICITY OF GASOLINE AND<br />
GASOLINE PLUS OXYGENATE ADDITIVES IN<br />
RATS. L. Twerdok 1 , V. L. Peachee 2 and K. L. White 2 .<br />
1 American Petroleum Institute, Washington, DC and<br />
2 ImmunoTox, Inc., Richmond, VA.<br />
Endorsed by:<br />
Immunotoxicology SS<br />
Inhalation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Although toxicity to the lung and cardiovascular system are the most frequently<br />
studied targets following inhalation exposure, suppression <strong>of</strong> systemic immune<br />
responses has been observed following exposure to a number <strong>of</strong> diverse<br />
compounds. Defects in a variety <strong>of</strong> immune effector mechanisms have been<br />
observed. Frequently, these effects are not a direct result <strong>of</strong> exposure <strong>of</strong> immune<br />
targets to the chemical or its metabolites, but involve instead the production <strong>of</strong><br />
mediators in the lung that circulate widely and/or interactions with the nervous<br />
system. Often these exposures are to complex mixtures and the active components<br />
as well as pharmacokinetics are uncertain. Many <strong>of</strong> these issues have been<br />
considered in recent studies <strong>of</strong> JP-8 Jet fuel, Sarin, Tobacco smoke, and different<br />
gasoline formulations, all <strong>of</strong> which suppress systemic immune response and<br />
have the potential to impact susceptibility to infectious disease and tumor challenge<br />
in rodents. These studies have implications for public health, homeland<br />
security, industrial hygiene, and indoor environments. This symposium is a<br />
sequel to a 2004 symposium Modulation <strong>of</strong> Host Defenses by Ambient and<br />
Source Particulate Air pollutants which focused on pulmonary immune<br />
responses and infections<br />
#18 9:30 OVERVIEW INHALATION EXPOSURE AND<br />
SYSTEMIC IMMUNOTOXICITY:<br />
MECHANISMS LINKING THE LUNG AND<br />
IMMUNE SYSTEM. M. Selgrade 1 and J. Zelik<strong>of</strong>f 2 .<br />
1 NHEERL, U.S. EPA, Research Triangle Park, NC and<br />
2 Department <strong>of</strong> Environmental Medicine, New York<br />
University School <strong>of</strong> Medicine, Tuxedo, NY.<br />
#19 9:35 INTRODUCTION: INHALATION EXPOSURE<br />
AND SYSTEMIC IMMUNOTOXICITY:<br />
MECHANISMS LINKING THE LUNG AND<br />
IMMUNE SYSTEM. M. Selgrade. NHEERL, U.S.<br />
EPA, Research Triangle Park, NC.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room RO6<br />
WORKSHOP SESSION: THE DEVELOPMENT AND APPLICATION<br />
OF BIOMARKERS OF TOXICITY<br />
Chairperson(s): Amy Lavin, International Life Sciences Institute, Washington,<br />
DC.<br />
Endorsed by:<br />
HESI Biomarkers Technical Committee<br />
Regulatory and Safety Evaluation SS*<br />
Risk Assessment SS<br />
Toxicologic and Exploratory Pathology SS<br />
A biomarker, or biological marker, is defined as a characteristic that is measured<br />
and evaluated as an indicator <strong>of</strong> normal biological processes, pathogenic<br />
processes, or pharmacological responses to a therapeutic intervention<br />
(FDA/NIH Definitions Working Group, 1999). Such biomarkers have long been<br />
used in preclinical safety studies during drug development. Nevertheless, many<br />
traditional biomarkers lack the sensitivity and specificity required to extrapolate<br />
results from preclinical studies to human clinical outcomes. As a result, interest<br />
in the discovery and validation <strong>of</strong> new bridging biomarkers <strong>of</strong> toxicity has<br />
expanded rapidly in recent years. This increase is due both to the advent <strong>of</strong> new<br />
“-omic” technologies, as well as to a shift in focus within the pharmaceutical<br />
companies and regulatory agencies towards finding safety biomarkers that can<br />
be <strong>of</strong> greater use in the drug discovery and safety assessment processes. These<br />
drivers have contributed to formation <strong>of</strong> the Health and Environmental Sciences<br />
Institute (HESI) Biomarkers Technical Committee, which is conducting a<br />
collaborative research program to evaluate possible new biomarkers for use in<br />
preclinical drug development. Biomarkers being explored by the committee for<br />
use in preclinical safety studies include serum cardiac troponins, a panel <strong>of</strong><br />
nephrotoxicity biomarkers (the GSTs, PAP-1, KIM-1, and clusterin), and<br />
inhibin B as a biomarker <strong>of</strong> testicular toxicity. The use <strong>of</strong> such biomarkers will<br />
allow for integrated mechanistic and hypothesis-building studies conducted in<br />
the laboratory to be confirmed in man and vice versa.<br />
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#24 9:30 THE DEVELOPMENT AND APPLICATION OF<br />
BIOMARKERS OF TOXICITY. J. Dean 2 and A. L.<br />
Lavin 1 . 1 ILSI Health and Environmental Sciences<br />
Institute, Washington, DC and 2 San<strong>of</strong>i-Synthelabo, Inc.,<br />
Malvern, PA.<br />
#25 9:40 NEW BRIDGING BIOMARKERS FOR SAFETY<br />
ASSESSMENT. J. T. MacGregor. <strong>Toxicology</strong><br />
Consulting Services, Arnold, MD.<br />
#26 10:05 SERUM CARDIAC TROPONINS AS<br />
BIOMARKERS OF DRUG-INDUCED<br />
CARDIOTOXICITY. M. J. York. Pathology,<br />
GlaxoSmithKline, Ware, Hertfordshire, United<br />
Kingdom. Sponsor: A. Lavin.<br />
#27 10:30 INHIBIN B AS A POTENTIAL BIOMARKER OF<br />
TESTICULAR TOXICITY. J. Stewart. Safety<br />
Assessment, AstraZeneca Pharmaceuticals,<br />
Macclesfield, Cheshire, United Kingdom. Sponsor: A.<br />
Lavin.<br />
#28 10:55 BIOMARKERS OF NEPHROTOXICITY. S.<br />
Beushausen 1 and A. Lavin 2 . 1 WWSS, Pfizer, Inc., St.<br />
Louis, MO and 2 Health and Environmental Sciences<br />
Institute, Washington, DC.<br />
#29 11:20 REGULATORY ASPECTS OF NEW<br />
BIOMARKERS OF TOXICITY. F. Frueh.<br />
FDA/CDER, Rockville, MD. Sponsor: A. Lavin.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room 220<br />
WORKSHOP SESSION: DOSE-ADDITIVITY OF MIXTURES:<br />
WHERE ARE WE GOING WITH THE SCIENCE?<br />
Chairperson(s): Rory Conolly, CIIT Centers for Health Research, Research<br />
Triangle Park, NC and William H. Farland, U.S. EPA, Washington, DC.<br />
Endorsed by:<br />
Carcinogenesis SS<br />
Mixtures Task Force*<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
A growing challenge in human risk assessment is development <strong>of</strong> methods to<br />
evaluate risks posed by low-level exposures to environmentally relevant<br />
mixtures. Development <strong>of</strong> Relative Potency factors (RPFs), which assume<br />
fundamental dose additivity, are currently used as the primary method for evaluating<br />
the risks <strong>of</strong> mixtures <strong>of</strong> compounds acting though similar modes <strong>of</strong><br />
action. Examples <strong>of</strong> these are the RPF schemes for dioxins (Toxic Equivalency<br />
Factors) and organophosphate and carbamate pesticides. The aim <strong>of</strong> the workshop<br />
is provide a broad overview and discussion <strong>of</strong> the state <strong>of</strong> the science for<br />
the use and justification <strong>of</strong> relative potency factors in environmental and human<br />
health risk assessment. The workshop will include presentations describing<br />
specific examples <strong>of</strong> how RPFs are currently applied to cancer assessments <strong>of</strong><br />
dioxin-like compounds and to non-cancer neurotoxicity endpoints such as<br />
exemplified by organophosphate and carbamate pesticides. The recently<br />
completed National <strong>Toxicology</strong> <strong>Program</strong> chronic rodent studies testing critical<br />
RPF hypotheses will be discussed as a specific example <strong>of</strong> the potential impact<br />
<strong>of</strong> experimental findings on RPF assumptions. In addition, the workshop will<br />
discuss the central importance <strong>of</strong> dosimetry and exposure assessments to evaluation<br />
<strong>of</strong> the RPF approach, particularly addressing implications for<br />
understanding potential health risks associated with low-level exposures to<br />
chemical mixtures. The Workshop presentations will be designed to engender<br />
both Panel and Audience discussion focused on defining the scientific justification<br />
and limitations <strong>of</strong> the use <strong>of</strong> RPF approaches, and identifying future<br />
research needs that will improve risk assessment tools used to assess health<br />
impacts associated with low-level exposures to a broad spectrum <strong>of</strong> environmental<br />
chemicals.<br />
#30 9:30 DOSE-ADDITIVITY OF MIXTURES: WHERE<br />
ARE WE GOING WITH THE SCIENCE? R.<br />
Conolly. CIIT Centers for Health Research, Research<br />
Triangle Park, NC.<br />
#31 9:40 CAN MODE OF ACTION PREDICT MIXTURE<br />
TOXICITY FOR RISK ASSESSMENT? C. J.<br />
Borgert 1,2 . 1 Applied Pharmacology and <strong>Toxicology</strong>,<br />
Inc., Gainesville, FL and 2 Physiological Sciences,<br />
University <strong>of</strong> FL College <strong>of</strong> Veterinary Medicine,<br />
Gainesville, FL.<br />
#32 10:10 THE USE OF TEFS IN ASSESSING MIXTURES<br />
OF DIOXINS, FURANS AND DIOXIN-LIKE PCBs.<br />
W. H. Farland, M. DeVito and L. Birnbaum. Office <strong>of</strong><br />
Research and Development, U.S. EPA, Washington,<br />
DC.<br />
#33 10:40 TESTING THE TOXIC EQUIVALENCY FACTOR<br />
(TEF) HYPOTHESIS: THE NTP DIOXIN/PCB<br />
CANCER BIOASSAYS. N. J. Walker 1 , M. E. Wyde 1 , P.<br />
W. Crockett 2 , A. Nyska 1 , J. R. Bucher 1 and C. J.<br />
Portier 1 . 1 NIEHS, Research Triangle Park, NC and<br />
2 Constella Group, Research Triangle Park, NC.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 51
44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
MONDAY<br />
#34 11:10 PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODELING AS<br />
AN ALTERNATIVE TO RELATIVE POTENCY<br />
FACTORS (RPFS) IN CUMULATIVE RISK<br />
ASSESSMENT: AN EXAMPLE WITH<br />
ACETYLCHOLINESTERASE- (ACHE)<br />
INHIBITING PESTICIDES. R. Conolly, J. Wang and<br />
Y. Tan. Center for Computational Systems Biology &<br />
Human Health Assessment, CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room RO2<br />
WORKSHOP SESSION: ROLE OF NUTRIGENOMICS IN SAFETY<br />
ASSESSMENT OF FUNCTIONAL FOODS<br />
Chairperson(s): Madhu Soni, Burdock Group, Vero Beach, FL and Timothy<br />
Zacharewski, Michigan State University, East Lansing, MI.<br />
Endorsed by:<br />
Food Safety SS*<br />
Mechanisms SS<br />
Risk Assessment SS<br />
The recent completion <strong>of</strong> human genome (blueprint) has triggered an explosion<br />
in research into how drugs might be individualized to capitalize on each patient<br />
s unique genetic code. The line between food and drug is blurring in the era <strong>of</strong><br />
the genome. It appears that the food industry is on the verge <strong>of</strong> a new era where<br />
companies will design foods and market them to consumers according to the<br />
consumer′s genetic makeup. Increased use <strong>of</strong> bioactive ingredients (so called<br />
functional foods) is challenging toxicologists when making safety determinations.<br />
This evaluation is different from that <strong>of</strong> drugs or toxins as efficacy or<br />
benefit analysis <strong>of</strong> the ingredients has not been factored in the safety determination.<br />
The evaluation <strong>of</strong> absorption, body distribution and metabolism will<br />
result in a realistic assessment <strong>of</strong> ranges in target tissue concentrations.<br />
Biological effects (both desirable and undesirable) can then be determined based<br />
upon genomic and proteomic changes, the result <strong>of</strong> which will be a bottom up<br />
approach rather than a top down methodology that imposes unrealistic safety<br />
factors. Thus, data from gene nutrient interaction will open the ways for new<br />
concepts <strong>of</strong> risk-benefit evaluation. The proposed workshop will cover recent<br />
discoveries in nutrition, genomics and proteomics and how these developments<br />
will change currently used methodology for risk assessment <strong>of</strong> bioactive/functional<br />
foods. This workshop will focus on applied genomic technologies and<br />
their impact on nutrition, health sciences and particularly on safety determination<br />
<strong>of</strong> functional foods. The objectives achieved will be: (1) Provide examples<br />
<strong>of</strong> the impact <strong>of</strong> genotype (cardiovascular diseases, cancer susceptibility,<br />
allergy, etc) on the response to foods and food components; (2) Identify relevant<br />
biomarkers that are applicable for assessing the benefits and risks <strong>of</strong> selected<br />
foods; (3) FDA s thinking on use <strong>of</strong> microarray data in regulatory approvals; and<br />
(4) Regulatory and other challenges in determining safety <strong>of</strong> “nutriomic” foods.<br />
#35 9:30 ROLE OF NUTRIGENOMICS IN SAFETY<br />
ASSESSMENT OF FUNCTIONAL FOODS. M. G.<br />
Soni 1 and T. R. Zacharewski 2 . 1 Burdock Group, Vero<br />
Beach, FL and 2 Biochemistry and Molecular Biology,<br />
Michigan State University, East Lansing, MI.<br />
#36 9:40 RISK ASSESSMENT OF FOOD AND FOOD<br />
COMPONENTS AT (NEAR) PHYSIOLOGICAL<br />
CONCENTRATIONS. B. van Ommen. Physiological<br />
Sciences, TNO Nutrition and Food Research, Zeist,<br />
Netherlands. Sponsor: M. Soni.<br />
#37 10:05 GENE AND PROTEIN EXPRESSION CHANGES<br />
DURING IMMUNE RESPONSES TO FOOD<br />
ALLERGENS. R. J. Dearman and I. Kimber. Syngenta<br />
CTL, Macclesfield, United Kingdom.<br />
#38 10:30 NUTRIGENOMICS AND INFLAMMATION. K.<br />
Kornman. Interleukin Genetics, Waltham, MA. Sponsor:<br />
M. Soni.<br />
#39 10:55 USE OF MICROARRAY DATA IN REGULATORY<br />
APPROVAL. D. G. Hattan and T. S. Thurmond. Office<br />
<strong>of</strong> Food Additive Safety, U.S. FDA Center for Food<br />
Safety & Applied Nutrition, College Park, MD.<br />
#40 11:20 IMPACT OF MOLECULAR NUTRITION ON THE<br />
SAFETY ASSESSMENT OF FUNCTIONAL<br />
FOODS: A SWOT ANALYSIS. P. Gillies 1,2 , P. Kris-<br />
Etherton 2 and J. Vanden Heuvel 3 . 1 Nutrition & Health,<br />
DuPont, Newark, DE, 2 Department <strong>of</strong> Nutritional<br />
Sciences, The Pennsylvania State University, State<br />
College, PA and 3 Department <strong>of</strong> Veterinary Medicine,<br />
The Pennsylvania State University, State College, PA.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room 208<br />
PLATFORM SESSION: NANO PARTICLES<br />
Chairperson(s): Mary Jane Cunningham, Houston Advanced Research<br />
Center, The Woodlands, TX and Adrian Nordone, Cabot Corporation, Billerica,<br />
MA.<br />
#41 9:30 A NEW GENERATION OF MULTIFUNCTIONAL<br />
NANOPARTICLES POSSESSING MAGNETIC<br />
MOTOR EFFECT FOR DRUG OR GENE<br />
DELIVERY. K. Yu 1 , J. Kim 1 , M. Cho 1 , B. Kim 2 , J.<br />
Lee 2 and T. Yoon 2 . 1 Laboratory <strong>of</strong> Toxiclogy, College <strong>of</strong><br />
Veterinary Medicine, Seoul National University, Seoul,<br />
South Korea and 2 Materials Chemistry Laboratory,<br />
School <strong>of</strong> Chemistry, Seoul National University, Seoul,<br />
South Korea.<br />
#42 10:00 THE AGGREGATION OF SINGLE-WALLED<br />
CARBON NANOTUBES IN FRESH WATER AND<br />
SEA WATER. H. Cheng and J. Cheng. Biology and<br />
Chemsitry, City University <strong>of</strong> Hong Kong, Hong Kong,<br />
N/A, Hong Kong.<br />
#43 10:30 PROTOCOLS FOR ASSESSING IN VITRO<br />
TOXICITY OF NANOPARTICULATES. M.<br />
Palazuelos 1 , A. Moraga 2 , K. Powers 1 and B. Moudgil 3 .<br />
1 Particle Engineering Research Center, University <strong>of</strong><br />
Florida, Gainesville, FL, 2 Interdisciplinary Center for<br />
Biotechnology Research, University <strong>of</strong> Florida,<br />
Gainesville, FL and 3 Center for Human and<br />
Environmental <strong>Toxicology</strong>, University <strong>of</strong> Florida,<br />
Gainesville, FL. Sponsor: S. Roberts.<br />
#44 11:00 ASSESSING THE POTENTIAL HAZARD OF<br />
ENGINEERED NANOPARTICLES IN THE<br />
WORK ENVIRONMENT. A. J. Nordone 1 , J. Jose 2<br />
and C. A. Gray 2 . 1 Cabot Corporation, Leuven, Belgium<br />
and 2 Cabot Corporation, Billerica, MA.<br />
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<strong>Program</strong> Description<br />
#45 11:30 GENE EXPRESSION PROFILING OF<br />
NANOSCALE MATERIALS USING A SYSTEMS<br />
BIOLOGY APPROACH. M. Cunningham 1 , S. R.<br />
Magnuson 2 and M. T. Falduto 2 . 1 Life Sciences &<br />
Health, Houston Advanced Research Center, The<br />
Woodlands, TX and 2 GenUs BioSystems, Inc., St.<br />
Charles, IL.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room RO1<br />
#52 11:30 TEMPORAL PARAMETERS OF<br />
ENVIRONMENTAL ENRICHMENT-INDUCED<br />
COGNITIVE ENHANCEMENT IN A RODENT<br />
MODEL OF LEAD NEUROTOXICITY. C. D.<br />
Toscano, J. L. McGlothan, J. R. Moss and T. R.<br />
Guilarte. Environmental Health Sciences, Johns<br />
Hopkins University, Baltimore, MD.<br />
Monday Morning, March 7<br />
9:30 AM to 12:00 NOON<br />
Room 207<br />
PLATFORM SESSION: NEUROTOXICITY: PHARMACOLOGICAL<br />
AND ENVIRONMENTAL INTERACTIONS<br />
Chairperson(s): Laurence Fechter, VA Medical Center, Loma Linda, CA and<br />
Carey N. Pope, Oklahoma State University, Stillwater, OK.<br />
#46 9:30 IN VITRO AND IN VIVO EXPOSURE TO ORTHO-<br />
SUBSTITUTED PCB 95 AND PCB 170 ALTER<br />
NEUROPLASTICITY IN THE RAT<br />
HIPPOCAMPAL SLICES. K. Kim 1 , I. N. Pessah 1 and<br />
T. E. Alberston 2 . 1 Molecular Biosciences:VM,<br />
U.C.Davis, Davis, CA and 2 Internal medicine :Medical<br />
school, U.C.Davis, Sacramento, CA.<br />
#47 9:50 OVEREXPRESSION OF NQO1 PROTECTS<br />
HUMAN DOPAMINERGIC SK-N-MC<br />
NEUROBLASTOMA CELLS AGAINST<br />
DOPAMINE INDUCED CELL DEATH. S. H. Inayat-<br />
Hussain 1,2 , K. S. Zafar 1 , A. Bao 1 and D. Ross 1 .<br />
1 Pharmacology Sciences, University <strong>of</strong> Colorado,<br />
Denver, CO and 2 Biomedical Science, Faculty <strong>of</strong> Allied<br />
Health Sciences, Universiti Kebangsaan Malaysia,<br />
Kuala Lumpur, WP, Malaysia.<br />
#48 10:10 FORCED EXERCISE ATTENUATES KAINIC<br />
ACID-INDUCED NEUROTOXICITY IN THE<br />
HIPPOCAMPUS OF C57BL/6J MICE. S. A.<br />
Benkovic, J. P. O’Callaghan and D. B. Miller. TMBB,<br />
CDC-NIOSH, Morgantown, WV.<br />
#49 10:30 EVALUATING THE NMDA-GLUTAMATE<br />
RECEPTOR AS A SITE OF ACTION FOR<br />
TOLUENE, IN VIVO. A. S. Bale 1 , Q. T. Krantz 2 , P. J.<br />
Bushnell 1 , T. J. Shafer 1 and W. K. Boyes 1 .<br />
1 Neurotoxicology Division, NHEERL, ORD, U.S. EPA,<br />
Research Triangle Park, NC and 2 Experimental<br />
<strong>Toxicology</strong> Division, NHEERL, ORD, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#50 10:50 INVOLVEMENT OF OXIDATIVE STRESS IN<br />
POTENTIATION OF NOISE INDUCED HEARING<br />
LOSS (NIHL) BY CHEMICAL CONTAMINANTS.<br />
L. D. fechter, B. Pouyatos and C. A. Gearhart. Research<br />
(151), Loma Linda VA Medical Center, Loma Linda,<br />
CA.<br />
#51 11:10 MODULATION OF CHOLINERGIC TOXICITY<br />
BY CANNABINOIDS. A. Nallapaneni, N. Mirajkar, S.<br />
Karanth and C. Pope. Physiological Sciences,<br />
Oklahoma State University, Stillwater, OK.<br />
PLATFORM SESSION: RECEPTORS: PPAR<br />
Chairperson(s): Jon Corton, Toxicogenomics, Chapel Hill, NC.<br />
#53 9:30 PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR α IS REGULATED BY GSK3. K. A.<br />
Burns and J. P. Vanden Heuvel. Center for Molecular<br />
<strong>Toxicology</strong> and Carcinogenesis, The Pennsylvania State<br />
University, University Park, PA.<br />
#54 9:50 PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR ALPHA- AND P53-RESPONSIVE<br />
GENE REGULATION BY RIBOSOMAL PROTEIN<br />
L11. L. Gopinathan 1 , J. P. Gray 2 and J. P. Vanden<br />
Heuvel 1 . 1 Center for Molecular <strong>Toxicology</strong> and<br />
Carcinogenesis, Penn State University, State College,<br />
PA and 2 Department <strong>of</strong> Pharmacology and <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ.<br />
#55 10:10 THE PEROXISOME PROLIFERATOR-<br />
ACTIVATED RECEPTOR-β(PPARβ) AGONIST<br />
GW0742 INHIBITS COLON CARCINOGENESIS.<br />
H. E. Marin 1 , A. N. Billin 2 , T. M. Willson 2 and J. M.<br />
Peters 3,1 . 1 Biochemistry, Microbiology, and Molecular<br />
Biology, The Pennsylvania State University, University<br />
Park, PA, 2 Nuclear Receptor Discovery Research,<br />
GlaxoSmithKline, Research Triangle Park, NC and<br />
3 Veterinary Science and the Center <strong>of</strong> Molecular<br />
<strong>Toxicology</strong> and Carcinogenesis, Pennsylvania State<br />
University, University Park, PA.<br />
#56 10:30 UNDERSTANDING GENE EXPRESSION<br />
CHANGES CONTROLLED BY THE<br />
PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTORα IN RATS. P. D. Cornwell 1 , W. J.<br />
Bailey 2 , A. T. De Souza 1 and R. G. Ulrich 1 . 1 Preclinical<br />
Molecular Pr<strong>of</strong>iling, Rosetta Inpharmatics LLC (a<br />
wholly owned subsidiary <strong>of</strong> Merck & Co. Inc.), Seattle,<br />
WA and 2 LSIT, Merck Research Laboratories, West<br />
Point, PA.<br />
#57 10:50 OVERLAPPING TRANSCRIPTIONAL<br />
PROGRAMS REGULATED BY THE NUCLEAR<br />
RECEPTORS PEROXISOME PROLIFERATOR-<br />
ACTIVATED RECEPTOR ALPHA, RETINOID X<br />
RECEPTOR AND LIVER X RECEPTOR IN<br />
MOUSE LIVER. A. Laughter 2 , S. P. Anderson 1 , C.<br />
Dunn 2 , L. Yoon 1 , C. Swanson 2 , R. Chandraratna 3 , T. M.<br />
Stulnig 4 , K. R. Steffensen 4 , J. Gustaffson 4 and J. C.<br />
Corton 5,2 . 1 GSK, Research Trangle Park, NC, 2 CIIT,<br />
Research Trangle Park, NC, 3 Allergan, Irvine, CA,<br />
4 Karolinska Institute, Huddinge, Sweden and<br />
5 ToxicoGenomics, Chapel Hill, NC.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 53
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#58 11:10 THE TRANSCRIPTIONAL RESPONSE TO A<br />
PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR ALPHA AGONIST INCLUDES<br />
INCREASED EXPRESSION OF PROTEOME<br />
MAINTENANCE GENES. S. P. Anderson 1 , P.<br />
Howroyd 2,3 , J. Liu 4 , X. Qian 4 , R. Bahnemann 5 , C.<br />
Swanson 3 , M. Kwak 6 , T. W. Kensler 6 and J. C.<br />
Corton 7,3 . 1 GSK, Research Triangle Park, NC, 2 EPL,<br />
Research Triangle Park, NC, 3 CIIT, Research Triangle<br />
Park, NC, 4 NCI at NIEHS, Research Triangle Park, NC,<br />
5 6 BASF, Ludwigshafen, Germany, Johns Hopkins<br />
University, Baltimore, MD and 7 ToxicoGenomics,<br />
Chapel Hill, NC.<br />
#59 11:30 ROLE OF PPARALPHA IN CALORIC<br />
RESTRICTION EFFECTS IN THE MOUSE<br />
LIVER. J. C. Corton 1,4 , U. Apte 2 , S. P. Anderson 3 , P.<br />
Limaye 2 , L. Yoon 3 , J. Latendresse 5 , J. Everitt 4 , K. A.<br />
Voss 6 , C. Kimbrough 3 , J. S. Wong 7 , S. S. Gill 7 , R. A.<br />
Chandraratna 8 , M. Kwak 9 , T. W. Kensler 9 , T. M.<br />
Stulnig 10 , K. R. Steffensen 10 , J. Gustafsson 10 and H. M.<br />
Mehendale 2 . 1 ToxicoGenomics, Chapel Hill, NC,<br />
2 3 University <strong>of</strong> Louisiana, Monroe, LA, GSK, Research<br />
Triangle Park, NC, 4 CIIT, Research Triangle Park, NC,<br />
5 6 7 PAI, Jefferson, AR, USDA, Athens, GA, University<br />
<strong>of</strong> California, Riverside, CA, 8 Allergan, Irvine, CA,<br />
9 Johns Hopkins University, Baltimore, MD and<br />
10 Karolinska Institute, Huddinge, Sweden.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: LIVER I<br />
Chairperson(s): Hartmut Jaeschke, University <strong>of</strong> Arizona, Tucson, AZ.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#60 TOXICOGENETIC ANALYSIS OF<br />
SUSCEPTIBILITY TO ACETAMINOPHEN-<br />
INDUCED LIVER INJURY. A. Hege 1 , C. Lodestro 3 ,<br />
D. Lee 3 , L. D. Balletta 3 , B. U. Bradford 2 , A. Maki 2 , R.<br />
Tennant 4 , M. A. Bogue 5 , K. Paigen 5 , D. W. Threadgill 1,3<br />
and I. Rusyn 1,2 . 1 Curriculum in <strong>Toxicology</strong>, UNC,<br />
Chapel Hill, NC, 2 Department <strong>of</strong> Environmental<br />
Sciences and Engineering, UNC, Chapel Hill, NC,<br />
3 Department <strong>of</strong> Genetics, UNC, Chapel Hill, NC,<br />
4 5 NIEHS, Research Triangle Park, NC and The Jackson<br />
Laboratory, Bar Harbor, ME.<br />
#61 PARACETAMOL TOXICITY IN RATS<br />
PRETREATED WITH CYTOCHROME P450 OR<br />
GLUTATHIONE INHIBITORS USING AN<br />
INTEGRATED GENOMICS APPROACH. M. F.<br />
DeCrist<strong>of</strong>aro 1 , D. Bodian 1 , E. Perentes 2 , I. M.<br />
Nicholls 2 , P. End 2 , J. Harleman 2 , S. Chibout 3 , F.<br />
Staedtler 3 and H. Firat 3 . 1 Biomarker Development,<br />
Novartis Pharmaceuticals Corporation, East Hanover,<br />
NY, 2 Preclinical Safety, Novartis Pharmacology AG,<br />
Basel, Switzerland and 3 Biomarker Development,<br />
Novartis Pharmacology AG, Basel, Switzerland.<br />
#62 DECREASED ACETAMINOPHEN AND<br />
BROMOBENZENE-INDUCED<br />
HEPATOTOXICITY AND LETHALITY IN TYPE 2<br />
DIABETIC MICE. M. S. Mitra 1 , S. P. Sawant 1 , A. V.<br />
Dnyanmote 1 , J. R. Latendresse 2 , A. Warbritton 2 and H.<br />
M. Mehendale 1 . 1 University <strong>of</strong> Louisiana at Monroe,<br />
Monroe, LA and 2 NCTR, Jefferson, AR.<br />
#63 ROLE OF POLY(ADP-RIBOSE) POLYMERASE<br />
(PARP) ACTIVATION IN ACETAMINOPHEN-<br />
INDUCED LIVER CELL NECROSIS IN MICE. C.<br />
Cover 1 , P. Fickert 2 , T. Knight 1 , A. Fuchsbichler 2 , M.<br />
Trauner 2 and H. Jaeschke 1 . 1 Liver Research Institute,<br />
University <strong>of</strong> Arizona, Tucson, AZ and 2 Department <strong>of</strong><br />
Medicine, Medical University <strong>of</strong> Graz, Graz, Austria.<br />
#64 PROTEOMIC ANALYSIS OF WHOLE LIVER<br />
AND SUBCELLULAR FRACTIONS FOLLOWING<br />
ACETAMINOPHEN-INDUCED<br />
HEPATOTOXICITY IN MALE RATS. M. E. Bruno 1 ,<br />
B. A. Wetmore 1 , J. H. Madenspacher 1 , R. Pieper 1 , A. M.<br />
McGrath 2 , C. L. Gatlin 2 , A. J. Makusky 2 , M. Zhao 2 , J.<br />
Zhou 2 , J. Taylor 2 , S. Steiner 2 , J. M. Fostel 1 , M. D.<br />
Waters 1 , R. W. Tennant 1 , K. B. Tomer 1 and B. A.<br />
Merrick 1 . 1 National Ctr Toxicogenomics, NIEHS,<br />
Research Triangle Pk, NC and 2 Proteomics Division,<br />
Large Scale Biology Corporation, Germantown, MD.<br />
#65 ROLE OF THE XENOBIOTIC RECEPTOR PXR<br />
IN ACETAMINOPHEN HEPATOTOXICITY. K. K.<br />
Wolf 2 , S. G. Wood 1 , B. W. Walton-Strong 3 , K. Yasuda 7 ,<br />
L. Lan 7 , P. R. Sinclair 1,3,2 , S. A. Wrighton 4 , E. H.<br />
Jeffery 5 , R. M. Evans 6 , E. G. Schuetz 7 and J. F.<br />
Sinclair 1,3,2 . 1 Veterans Administration Medical Center,<br />
White River Junction, VT, 2 Pharmacology and<br />
<strong>Toxicology</strong>, Dartmouth Medical School, Hanover, NH,<br />
3 Biochemistry, Dartmouth Medical School, Hanover,<br />
NH, 4 Department <strong>of</strong> Drug Disposition, Lilly Research<br />
Laboratories, Indianapolis, IN, 5 Department <strong>of</strong> Food<br />
Science and Human Nutrition, University <strong>of</strong> Illinois,<br />
Urbana, IL, 6 Howard Hughes Medical Institute, Gene<br />
Expression Laboratory, The Salk Institute for Biological<br />
Studies, La Jolla, CA and 7 Department <strong>of</strong><br />
Pharmaceutical Sciences, St. Jude Children’s Research<br />
Hospital, Memphis, TN.<br />
#66 THE EFFECT OF S-ADENOSYL-L-METHIONINE<br />
(SAME)ON MITOCHONDRIAL GLUTATHIONE<br />
AND PROTEIN CARBONYLS FOLLOWING<br />
ACETAMINOPHEN (APAP) TREATMENT IN<br />
MICE. M. Terneus, K. Kiningham and M. Valentovic.<br />
Pharmacology, Marshall University School <strong>of</strong> Medicine,<br />
Huntington, WV.<br />
#67 EVIDENCE SUGGESTING A ROLE FOR<br />
NAD(P)H:QUINONE OXIDOREDUCTASE 1 IN<br />
THE PROTECTION AGAINST<br />
ACETAMINOPHEN HEPATOTOXICITY BY<br />
CLOFIBRATE TREATMENT. J. S. M<strong>of</strong>fit 1 , L. M.<br />
Aleksunes 1 , A. M. Slitt 2 , M. Kardas 1 , C. D. Klaassen 2<br />
and J. E. Manautou 1 . 1 Department <strong>of</strong> Pharmaceutical<br />
Sciences, University <strong>of</strong> Connecticut, Storrs, CT and<br />
2 Department <strong>of</strong> Pharmacology, <strong>Toxicology</strong> and<br />
Therapeutics, University <strong>of</strong> Kansas Medical Center,<br />
Kansas City, KS.<br />
54<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#68 ROLE OF VASCULAR ENDOTHELIAL GROWTH<br />
FACTOR (VEGF) IN ACETAMINOPHEN<br />
HEPATOTOXICITY. B. Donahower 1 , S. S.<br />
McCullough 2 and L. P. James 3,2 . 1 Pharmacology,<br />
University <strong>of</strong> Arkansas For Medical Sciences, Little<br />
Rock, AR, 2 <strong>Toxicology</strong>, University <strong>of</strong> Arkansas For<br />
Medical Sciences, Little Rock, AR and 3 Arkansas<br />
Children’s Hospital Research Institute, Little Rock, AR.<br />
Sponsor: J. Hinson.<br />
#69 LIPOPOLYSACCHARIDE POTENTIATES<br />
ACETAMINOPHEN HEPATOTOXICITY. S. W.<br />
Newport, C. M. Dugan, X. Deng, P. E. Ganey, R. A.<br />
Roth and J. F. Maddox. Pharmacology and <strong>Toxicology</strong>,<br />
National Food Safety and <strong>Toxicology</strong> Center, Michigan<br />
State University, East Lansing, MI.<br />
#70 POTENTIATION OF 3-(3, 5-<br />
DICHLOROPHENYL)-2, 4-<br />
THIAZOLIDINEDIONE (DCPT)-INDUCED<br />
HEPATOTOXICITY IN RATS BY<br />
DEXAMETHASONE (DEX) PRETREATMENT. C.<br />
M. Crincoli, N. N. Patel, R. Tchao and P. J. Harvison.<br />
Department <strong>of</strong> Pharmaceutical Sciences, University <strong>of</strong><br />
the Sciences in Philadelphia, Philadelphia, PA.<br />
#71 PROTECTIVE EFFECT OF DIBROMOACETATE<br />
IN PRIMARY HEPATOCYTE CULTURES. J. M.<br />
McMillan and K. McKelvey. Pharmacology, Medical<br />
University <strong>of</strong> South Carolina, Charleston, SC.<br />
#72 NICOTINAMIDE ALTERATION OF<br />
BROMOBENZENE-INDUCED<br />
HEPATOTOXICITY. K. W. Hall 1 , P. C. Grivas 1 , C.<br />
Muro-Cacho 2 and R. D. Harbison 1,2 . 1 <strong>Toxicology</strong>,<br />
University <strong>of</strong> South Florida, Tampa, FL and 2 Pathology,<br />
College <strong>of</strong> Medicine, University <strong>of</strong> South Florida,<br />
Tampa, FL.<br />
#73 COLCHICINE ANTIMITOSIS ABOLISHES<br />
SUBCHRONIC CHLOROFORM-INDUCED<br />
PROTECTION AGAINST LETHAL DOSE OF<br />
CHLOROFORM. B. K. Philip 1 , S. S. Anand 2 , P. S.<br />
Palkar 1 , M. M. Mumtaz 3 , J. R. Latendresse 4 and H. M.<br />
Mehendale 1 . 1 Department <strong>of</strong> <strong>Toxicology</strong>, University <strong>of</strong><br />
Louisiana at Monroe, Monroe, LA, 2 University <strong>of</strong><br />
Georgia, Athens, GA, 3 ATSDR, CDC, Chamblee, GA<br />
and 4 NCTR, Jefferson, AR.<br />
#74 UNDERNUTRITION FAILS TO EXACERBATE<br />
ALCOHOL-INDUCED LIVER DAMAGE<br />
DESPITE EVIDENCE OF INCREASED<br />
OXIDATIVE STRESS. J. N. Baumgardner 1,2 , B. N.<br />
Yarberry 2 , J. V. Badeaux 2 , M. Hidestrand 1,2 , K.<br />
Shankar 1,2 , T. M. Badger 2,3 and M. J. Ronis 1,2 .<br />
1 Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Arkansas<br />
for Medical Sciences (UAMS), Little Rock, AR,<br />
2 Arkansas Children’s Nutrition Center, Little Rock, AR<br />
and 3 Physiology and Biophysics, UAMS, Little Rock,<br />
AR.<br />
#75 RESILIENCY OF AGED FISCHER 344 RATS TO<br />
CHLORDECONE-AMPLIFIED CARBON<br />
TETRACHLORIDE TOXICITY. H. M. Mehendale,<br />
B. Murali and M. C. Korrapati. <strong>Toxicology</strong>, University<br />
<strong>of</strong> Louisiana at Monroe, Monroe, LA.<br />
#76 PENTOXIFYLLINE AND ANTI-TUMOR<br />
NECROSIS FACTOR α ANTIBODIES ARE<br />
UNABLE TO PROTECT MICE FROM<br />
FUMONISIN HEPATOTOXICITY. Q. He and R. P.<br />
Sharma. The University <strong>of</strong> Georgia, Athens, GA.<br />
#77 CALPASTATIN OVER-EXPRESSION PROTECTS<br />
AGAINST TOXICANT-INDUCED PROGRESSION<br />
OF INJURY ASSOCIATED WITH ACUTE LIVER<br />
FAILURE IN MICE. P. B. Limaye 1 , V. S. Bhave 1 , P. S.<br />
Palkar 1 , J. R. Latendresse 2 , S. Yu 3 , J. K. Reddy 3 and H.<br />
M. Mehendale 1 . 1 <strong>Toxicology</strong>, University <strong>of</strong> Louisiana at<br />
Monroe, Monroe, LA, 2 NCTR, Jefferson, AR and<br />
3 Northwestern University, Chicago, IL.<br />
#78 IMPAIRED HEPATIC REGENERATION IN<br />
METALLOTHIONEIN KNOCKOUT MICE<br />
AFTER PARTIAL HEPATECTOMY. J. R. Oliver<br />
and G. Cherian. Pathology, University <strong>of</strong> Western<br />
Ontario, London, ON, Canada.<br />
#79 THE ROLE OF GLUTATHIONE DEPLETION<br />
AND OXIDATIVE STRESS ON CYTOTOXICITY<br />
OF CHROMIUM (VI) IN ISOLATED RAT<br />
HEPATOCYTES. O. S. El-Tawil 1 , A. M. Mohamadin 2<br />
and A. H. Abou-Hadeed 3 . 1 <strong>Toxicology</strong> and Forensic<br />
Medicine, Faculty <strong>of</strong> Veterinary Medicine, Cairo<br />
University, Cairo, Egypt, 2 Department <strong>of</strong> Biochemistry,<br />
Faculty <strong>of</strong> Pharmacy, Al-Azhar University, Cairo, Egypt<br />
and 3 Department <strong>of</strong> Forensic Medicine and <strong>Toxicology</strong>,<br />
Faculty <strong>of</strong> Veterinary Medicine, Zagazig University,<br />
Zagzig, Egypt.<br />
#80 ANTI-HYPERCHOLESTEROLEMIA DRUGS IN<br />
THE STATIN CLASS REDUCE GLUTATHIONE<br />
LEVELS AND INCREASE CASPASE 3<br />
ACTIVATION IN AN IN VITRO CELL MODEL. J.<br />
F. Pregenzer, J. M. McKim, Jr., P. C. Wilga and D. K.<br />
Petrella. CeeTox, Kalamazoo, MI.<br />
#81 EFFECT OF THIAZOLIDINEDIONE (TZD) RING<br />
MODIFICATION ON 3-(3, 5-<br />
DICHLOROPHENYL)-2, 4-<br />
THIAZOLIDINEDIONE (DCPT) INDUCED<br />
HEPATOTOXICITY IN RATS. N. N. Patel, C. M.<br />
Crincoli, R. Tchao and P. J. Harvison. Department <strong>of</strong><br />
Pharmaceutical Sciences, University <strong>of</strong> the Sciences in<br />
Philadelphia, Philadelphia, PA.<br />
#82 ENDOGENOUS FATTY ACID METHYL ESTERS<br />
AS A POTENTIAL MARKER OF HUMAN<br />
HEPATOCELLULAR CARCINOMA. S. H. Khan, B.<br />
S. Kaphalia and G. Ansari. Pathology, UTMB,<br />
Galveston, TX.<br />
#83 AN INVESTIGATION INTO THE<br />
RELATIONSHIP OF VITAMIN A LEVELS AND<br />
HEPATITIS, HYPERPLASIA, BENIGN OR<br />
MALIGNANT LESIONS IN RODENT LIVERS. C.<br />
Bray. Covance Laboratories Ltd., Harrogate, United<br />
Kingdom. Sponsor: D. Everett.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 55
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RECEPTOR: AH RECEPTOR II<br />
Chairperson(s): Michael Denison, University <strong>of</strong> California, Davis, Davis,<br />
CA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#84 CHARACTERIZATION OF A HIGH-POTENCY<br />
ENDOGENOUS LIGAND FOR THE ARYL<br />
HYDROCARBON RECEPTOR. E. C. Henry 1 , J. C.<br />
Bemis 1 , A. S. Kende 2 and T. A. Gasiewicz 1 .<br />
1 Environmental Medicine, University <strong>of</strong> Rochester,<br />
Rochester, NY and 2 Chemistry, University <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#85 NATURALLY OCCURRING ANTAGONISTS OF<br />
AHR PATHWAY: A NOVEL APPROACH OF<br />
CANCER CHEMOPREVENTION? D. puppala and<br />
H. Swanson. Pharmacology, University <strong>of</strong> Kentucky,<br />
Lexington, KY.<br />
#86 IMPACT OF NH-TERMINAL TAGS ON AH<br />
RECEPTOR LOCALIZATION AND<br />
DEGRADATION IN CELL CULTURE. J.<br />
McQuown 2,1 , J. Wentworth 1 , E. Dougherty 1 and R. S.<br />
Pollenz 1 . 1 Biology, University <strong>of</strong> South Florida, Tampa,<br />
FL and 2 Cancer Biology, M<strong>of</strong>fitt Cancer Center, Tampa,<br />
FL.<br />
#87 COMPUTATIONAL APPROACH TOWARDS<br />
IDENTIFYING GENES WITH DIOXIN<br />
RESPONSE ELEMENTS IN HUMAN, MOUSE,<br />
AND RAT GENOMES. C. Vezina, H. M. Theobald<br />
and R. E. Peterson. School <strong>of</strong> Pharmacy, UW-Madison,<br />
Madison, WI.<br />
#88 IDENTIFICATION OF ZEBRAFISH ARNT1<br />
HOMOLOGS: TCDD DEVELOPMENTAL<br />
TOXICITY IN ZEBRAFISH REQUIRES ARNT1.<br />
A. L. Prasch 1 , R. L. Tanguay 2 , W. Heideman 1 and R. E.<br />
Peterson 1 . 1 University <strong>of</strong> Wisconsin, Madison, WI and<br />
2 Environmental & Molecular <strong>Toxicology</strong>, Oregon State<br />
University, Corvallis, OR.<br />
#89 5, 6-LEUKOTRIENE A4 A IS POTENT<br />
ACTIVATOR OF THE AH RECEPTOR. C. R.<br />
Chiaro 1 , A. D. Jones 2 , Y. Cao 1 , J. Born 3 , C. Marcus 3<br />
and G. H. Perdew 1 . 1 Veterinary Science, Penn State<br />
University, University Park, PA, 2 Chemistry, Penn State<br />
University, University Park, PA and 3 <strong>Toxicology</strong>,<br />
University <strong>of</strong> New Mexico, Albuquerque, NM.<br />
#90 ER-α REPRESSES TCDD-INDUCIBLE CYP1A1<br />
GENE TRANSCRIPTION THROUGH A DIRECT<br />
PROTEIN-PROTEIN INTERACTION WITH<br />
AHR/ARNT. T. Beischlag and G. H. Perdew. Center<br />
for Molecular <strong>Toxicology</strong> and Carcinogenesis,<br />
Department <strong>of</strong> Veterinary Sciences, Penn State<br />
University, University Park, PA.<br />
#91 ROLE OF ARNT2 IN NORMAL DEVELOPMENT<br />
BUT NOT TCDD DEVELOPMENTAL TOXICITY<br />
IN ZEBRAFISH. A. J. HILL 1 , A. L. Prasch 2,1 , W.<br />
Heideman 1,2 and R. E. Peterson 1,2 . 1 School <strong>of</strong><br />
Pharmacy, University <strong>of</strong> Wisconsin, Madison, WI and<br />
2 Molecular and Environmental <strong>Toxicology</strong> Center,<br />
University <strong>of</strong> Wisconsin, Madison, WI.<br />
#92 ALTERED CELL CYCLE REGULATION IN AH<br />
RECEPTOR-NULL MOUSE FIBROBLASTS. X.<br />
Chang and A. Puga. Environmental Health, University<br />
<strong>of</strong> Cincinnati Medical Center, Cincinnati, OH.<br />
#93 COMPARISONS OF RAT LIVER GENE<br />
EXPRESSION PROFILES FOR TCDD, D3T AND<br />
I3C: IMPLICATIONS FOR THE TOXICITY<br />
EQUIVALENCE FACTOR (TEF) APPROACH. C.<br />
Sutter 1 , K. Illouz 2 , A. Possolo 2 , S. Goodwin 1 , Y.<br />
Huang 1 , T. Kensler 3 , J. Silkworth 2 and T. Sutter 1 .<br />
1 Feinstone Center for Genomic Research, University <strong>of</strong><br />
Memphis, Memphis, TN, 2 Global Research, GE,<br />
Schenectady, NY and 3 Environmental Health Sciences,<br />
Johns Hopkins Bloomberg School <strong>of</strong> Public Health,<br />
Baltimore, MD.<br />
#94 NATURALLY OCCURRING MARINE<br />
COMPOUNDS SHOW A SPECIES-SPECIFIC<br />
DIFFERENCE IN AHR DRIVEN REPORTER<br />
GENE EXPRESSION. D. DeGroot 1 , M. E. Hahn 2 , B.<br />
K. Carte 3 , T. Higa 4 and M. S. Denison 1 . 1 Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California, Davis, CA,<br />
2 Woods Hole Oceanographic Institution, Woods Hole,<br />
MA, 3 Ancile Pharmaceuticals, San Diego, CA and<br />
4 University <strong>of</strong> Ryukyus, Okinawa, Japan.<br />
#95 PERSISTENT BINDING OF LIGANDS TO THE<br />
HEPATIC AH RECEPTOR FROM VARIOUS<br />
SPECIES. J. E. Bohonowych and M. S. Denison.<br />
Environmental <strong>Toxicology</strong>, University <strong>of</strong> California<br />
Davis, Davis, CA.<br />
#96 TCDD EXPOSURES ACTIVATE PKC, MAPK AND<br />
NFKB SIGNALING PATHWAYS IN HUMAN<br />
CANCER CELLS. C. K. Yu, M. H. Wong and C. K.<br />
Wong. Biology, Hong Kong Baptist University, Hong<br />
Kong, China.<br />
#97 THE ARYL HYDROCARBON RECEPTOR (AHR)<br />
ANTAGONIST EGCG, INHIBITS AHR<br />
ACTIVATION THROUGH AN INDIRECT<br />
MECHANISM INVOLVING BINDING TO HSP90:<br />
A NOVEL MECHANISM FOR A REPORTED<br />
ANTI-CANCER AGENT. C. M. Palermo and T. A.<br />
Gasiewicz. Department <strong>of</strong> Environmental Medicine,<br />
University <strong>of</strong> Rochester, Rochester, NY.<br />
#98 A NOVEL ARNT-INTERACTING PEPTIDE AINP2<br />
ENHANCES THE ARYL HYDROCARBON<br />
RECEPTOR SIGNALING. Y. Li, T. C. Luu and W. K.<br />
Chan. Thomas J. Long School <strong>of</strong> Pharmacy & Health<br />
Sciences, University <strong>of</strong> the Pacific, Stockton, CA.<br />
#99 THE ROLE OF THE JUN N-TERMINAL KINASE<br />
PATHWAYS IN THE TISSUE-SPECIFIC TCDD<br />
TOXICITY. Z. Tan, A. Puga and Y. Xia. Environmental<br />
Health, University <strong>of</strong> Cincinnati, Cincinnati, OH.<br />
56<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#100 ISOLATION AND CHARACTERIZATION OF<br />
THE CYP1A1 PROMOTER REGION FROM<br />
ZEBRAFISH. J. Wentworth and R. S. Pollenz. Biology,<br />
University <strong>of</strong> South Florida, Tampa, FL.<br />
#101 MICROARRAY EXAMINATION OF TCDD<br />
MEDIATED CHANGES IN GENE EXPRESSION<br />
IN HEPA1C1C7 MURINE HEPATOMA CELLS. E.<br />
Dere, D. R. Boverh<strong>of</strong>, L. D. Burgoon and T. R.<br />
Zacharewski. Department <strong>of</strong> Biochemistry & Molecular<br />
Biology, Department <strong>of</strong> Pharmacology & <strong>Toxicology</strong>,<br />
Center for Integrative <strong>Toxicology</strong>, National Food Safety<br />
& <strong>Toxicology</strong> Center, Michigan State University, East<br />
Lansing, MI.<br />
#102 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN<br />
ALTERS EXPRESSION OF RETINOIC ACID<br />
RECEPTORS IN NORMAL HUMAN<br />
KERATINOCYTES. K. A. Murphy, C. M. Villano and<br />
L. A. White. Biochemistry and Microbiology, Rutgers<br />
University, New Brunswick, NJ.<br />
#103 HEPATIC GENE EXPRESSION IN AHR-/- AND<br />
C57BL/6J MICE TREATED WITH 7H-<br />
DIBENZO[C, G]CARBAZOLE. D. Warshawsky, M.<br />
Genter, B. Warner, S. Goins, K. LaDow, A. Puga, M.<br />
Sartor and M. Medvedovic. Environmental Health,<br />
University <strong>of</strong> Cincinnati College <strong>of</strong> Medicine,<br />
Cincinnati, OH.<br />
#104 ARYL HYDROCARBON RECEPTOR<br />
ACTIVATION INHIBITS E2F1-INDUCED<br />
APOPTOSIS. J. L. Marlowe, X. Chang and A. Puga.<br />
Environmental Health, University <strong>of</strong> Cincinnati,<br />
Cincinnati, OH.<br />
#105 ARNT1 AND ARNT2 ARE EXPRESSED IN<br />
HUMAN KERATINOCYTES IN VITRO. K. N. De<br />
Abrew 1 and B. Allen-H<strong>of</strong>fmann 1,2 . 1 Molecular and<br />
Environmental <strong>Toxicology</strong> Center, University <strong>of</strong><br />
Wisconsin, Madison, WI and 2 Department <strong>of</strong> Pathology<br />
and Laboratory Medicine, University <strong>of</strong> Wisconsin,<br />
Madison, WI.<br />
#106 DETECTION OF AH RECEPTOR LIGANDS IN<br />
EXTRACTS FROM COMMON COMMERCIAL<br />
AND CONSUMER PRODUCTS USING AHR-<br />
BASED BIOASSAYS. M. S. Denison 1 , W. J. Rogers 1 ,<br />
J. E. Bohonowych 1 , M. Ziccardi 1 , T. Pedersen 2 , K.<br />
Dettmer 2 , B. D. Hammock 2 and B. Zhao 1 .<br />
1 Environmental <strong>Toxicology</strong>, University <strong>of</strong> California,<br />
Davis, CA and 2 Entomology, University <strong>of</strong> California,<br />
Davis, CA.<br />
#107 INTERACTION BETWEEN THE AH RECEPTOR<br />
AND NF-KB PATHWAYS: ANTAGONISM AT<br />
THE LEVEL OF HISTONE MODIFICATIONS. T.<br />
Z. Yu, S. Ke and Y. Tian. Texas A&M University,<br />
College Station, TX.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: GENE EXPRESSION-I<br />
Chairperson(s): Lori White, Rutgers University, New Brunswick, NJ.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#108 INTEGRATED ANALYSIS OF GENE<br />
EXPRESSION DATA, LITERATURE, AND<br />
BIOLOGICAL PATHWAYS OF MOUSE<br />
EMPHYSEMA STUDY. V. L. Burnett 1 , P. J. Monroe 1 ,<br />
K. Lee 2 and J. G. Pounds 3 . 1 OmniViz, Inc., Maynard,<br />
MA, 2 Battelle <strong>Toxicology</strong> Northwest, Richland, WA and<br />
3 Pacific Northwest National Laboratory, Richland, WA.<br />
#109 TRANSCRIPTIONPATH, A NOVEL METHOD<br />
THAT IDENTIFIES AND QUANTIFIES GENE<br />
TRANSCRIPTION, DETECTS CHANGES<br />
ASSOCIATED WITH TOXICOLOGY. M. E.<br />
Warren 1 , V. Alexiadis 1 , B. Egan 1 , J. Cashman 2 and P.<br />
Labhart 1 . 1 Genpathway, Inc., San Diego, CA and<br />
2 Human BioMolecular Research Institute, San Diego,<br />
CA. Sponsor: D. Schlenk.<br />
#110 CELL BASED ASSAYS REVEAL INDIVIDUAL<br />
AND COOPERATIVE ROLES FOR THE GLI<br />
TRANSCRIPTION FACTORS IN MEDIATING<br />
THE HEDGEHOG SIGNAL. R. J. Lipinski 2,1 and W.<br />
Bushman 1,2 . 1 Surgery, University <strong>of</strong> Wisconsin-<br />
Madison, Madison, WI and 2 Molecular and<br />
Environmental <strong>Toxicology</strong> Center, University <strong>of</strong><br />
Wisconsin-Madison, Madison, WI.<br />
#111 TOXICOGENOMIC ANALYSIS OF INTESTINAL<br />
RESPONSES TO NORMAL OR IMBALANCED<br />
HUMAN MICROFLORA IN GERM-FREE MICE<br />
OR HFA MICE EXPOSED TO<br />
ANTIMICROBIALS. S. jeong, S. Park, H. Kang and<br />
J. Cho. <strong>Toxicology</strong> Division, National Veterinary<br />
Research & Quarantine Service, Anyang, South Korea.<br />
#112 INDUCTION OF CYCLOOXYGENASE-2 BY<br />
CORTICOSTERONE IN CARDIOMYOCYTES. H.<br />
Sun and Q. M. Chen. Pharmacology, University <strong>of</strong><br />
Arizona, Tucson, AZ.<br />
#113 DEVELOPING AN IN VITRO GENE<br />
EXPRESSION ASSAY FOR PREDICTING<br />
HEPATOTOXICITY. S. abel, Y. Yang and J. Waring.<br />
Toxicogenomics, Abbott Laboratories, Abbott Park, IL.<br />
#114 ELUCIDATION OF THE MECHANISM OF<br />
KINASE INHIBITOR-INDUCED KIDNEY AND<br />
LIVER TOXICITY USING THE “OMICS”<br />
TECHNOLOGIES. P. S. Rao 1 , M. Wojke 1 , M.<br />
Hower 1 , T. Connolly 2 , J. Gautier 1 , J. Leonard 1 , A.<br />
Amberg 1 , M. Kurz 4 , H. Juretschke 3 , M. Valerio 1 , M.<br />
Pino 1 , K. Morgan 1 and Z. Jayyosi 1 . 1 Drug Safety<br />
Evaluation, Aventis, Bridgewater, NJ, 2 Cambridge<br />
Genomics Center, Aventis, Boston, MA, 3 Biomarkers,<br />
Aventis, Frankfurt, Germany and 4 Chemistry, Aventis,<br />
Frankfurt, Germany.<br />
MONDAY<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#115 CHARACTERIZATION OF FUNCTIONAL<br />
VARIATION IN HUMAN GSTM3 IN GLIOMA<br />
CELLS USING RNAI. X. Liu, M. R. Campbell, G. S.<br />
Pittman and D. A. Bell. Molecular genetics, NIEHS,<br />
Research Triangle Park, NC.<br />
#116 DIFFERENTIAL GENE EXPRESSION IN F344<br />
RATS FOLLOWING EXPOSURE TO EITHER<br />
POLYBROMINATED DIPHENYL ETHERS<br />
(PBDES) OR PCBs. J. M. Sanders 1,2 , L. T. Burka 1 and<br />
M. L. Cunningham 1 . 1 Laboratory <strong>of</strong> Pharmacology and<br />
Chemistry, NIEHS, Research Triangle Park, NC and<br />
2 Department <strong>of</strong> <strong>Toxicology</strong>, NC State University,<br />
Raleigh, NC.<br />
#117 EXTRACTION OF GENES WITH STABLE<br />
EXPRESSION IN RAT LIVER TREATED WITH<br />
VARIOUS COMPOUNDS–ANALYSIS OF THE<br />
DATA IN THE TOXICOGENOMICS PROJECT IN<br />
JAPAN -. H. UEDA, T. KASAHARA, H. TOTSUKA,<br />
T. MIYAGISHIMA, T. URUSHIDANI and T. NAGAO.<br />
Toxicogenomics Project, National Institute <strong>of</strong> Health<br />
Science, Setagayaku, Tokyo, Japan. Sponsor: T.<br />
INOUE.<br />
#118 CHARACTERIZATION OF AN ACUTE<br />
MOLECULAR MARKER OF NON-GENOTOXIC<br />
HEPATOCARCINOGENESIS IN RODENTS BY<br />
GENE EXPRESSION PROFILING IN A LONG-<br />
TERM CLOFIBRIC ACID STUDY. C. Michel 1 , C.<br />
Desdouets 2 , R. A. Roberts 1,3 , K. R. Isaacs 4 and E.<br />
Boitier 1 . 1 Drug Safety Evaluation, San<strong>of</strong>i Aventis,<br />
Vitry-sur-Seine, France, 2 INSERM U370, Paris, France,<br />
3 Safety Assessment, AstraZeneca, Cheshire, United<br />
Kingdom and 4 CITP, Harrogate, United Kingdom.<br />
#119 PROFILES OF GLOBAL GENE EXPRESSION IN<br />
IONIZING RADIATION-DAMAGED HUMAN<br />
DIPLOID FIBROBLASTS REVEAL<br />
SYNCHRONIZATION BEHIND THE G1<br />
CHECKPOINT. T. Zhou 1 , J. W. Chou 2 , D. A.<br />
Simpson 1 , Y. Zhou 1 , T. E. Mullen 1 , M. Medeiros 1 , P. R.<br />
Bushel 2 , R. S. Paules 2 , X. Yang 1 , P. Hurban 3 , E. K.<br />
Lobenh<strong>of</strong>er 3 and W. K. Kaufmann 1 . 1 Pathology & Lab.<br />
Medicine, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC, 2 National Institute <strong>of</strong> Environmental Health<br />
Science, Research Triangle Park, NC and 3 Paradigm<br />
Genetics, Research Triangle Park, NC.<br />
#120 EXPRESSION OF THE HELIX-LOOP-HELIX<br />
INHIBITOR OF DNA BINDING-1 (ID-1) GENE IS<br />
REGULATED BY RETINOIC ACID IN NORMAL<br />
HUMAN KERATINOCYTES. L. A. White and C. M.<br />
Villano. Biochemistry and Microbiology, Rutgers<br />
University, New Brunswick, NJ.<br />
#121 APPLICATION OF A CROSS-PLATFORM RNA<br />
STANDARD FOR ASSESSING MICROARRAY<br />
DATA COMPARABILITY. P. S. Pine 1 , B. A.<br />
Rosenzweig 1 , J. C. Fuscoe 2 , C. A. Afshari 3 , H. K.<br />
Hamadeh 3 , J. D. Retief 4 , Y. Turpaz 4 , E. Blomme 5 , R.<br />
Ciurlionis 5 , J. F. Waring 5 , R. S. Paules 6 , C. J. Tucker 6 ,<br />
T. L. Fare 7 , E. M. C<strong>of</strong>fey 7 , Y. He 7 , J. Collins 8 , K.<br />
Jarnagin 9 , S. Fujimoto 9 , G. L. Kiser 10 , T. Kaysser-<br />
Kranich 10 , F. D. Sistare 11 , J. Sina 11 and K. Thompson 1 .<br />
1 2 CDER, U.S. FDA, Silver Spring, MD, NCTR, U.S.<br />
FDA, Jefferson, AR, 3 Amgen Inc., Thousand Oaks, CA,<br />
4 5 Affymetrix Inc., Santa Clara, CA, Abbott<br />
Laboratories, Abbott Park, IL, 6 NIEHS, Research<br />
Triangle Park, NC, 7 Rosetta Inpharmatics, Seattle, WA,<br />
8 9 Agilent Technologies, Santa Clara, CA, Iconix<br />
Pharmaceuticals, Mountain View, CA, 10 GE Healthcare,<br />
Chandler, AZ and 11 Merck & Co. Inc., West Point, PA.<br />
#122 GENE EXPRESSION MODIFICATIONS IN A<br />
MOUSE EMPHYSEMA MODEL INDUCED BY<br />
ELASTASE. Q. Meng 1 , K. M. Waters 2 , J. M. Malard 2 ,<br />
K. Lee 1 and J. G. Pounds 2 . 1 Battelle <strong>Toxicology</strong><br />
Northwest, Richland, WA and 2 Pacific Northwest<br />
National Laboratories, Richland, WA.<br />
#123 TUMOR SUBTYPE CHEMOTHERAPEUTIC<br />
RESPONSES IN THE BREAST. K. Hoadley 1 , M. A.<br />
Troester 2 and C. M. Perou 1,2,3 . 1 Curriculum in Genetics<br />
and Molecular Biology, University <strong>of</strong> North Carolina,<br />
Chapel Hill, NC, 2 Lineberger Comprehensive Cancer<br />
Center, University <strong>of</strong> North Carolina, Chapel Hill, NC<br />
and 3 Department <strong>of</strong> Genetics, University <strong>of</strong> North<br />
Carolina, Chapel Hill, NC. Sponsor: J. Swenberg.<br />
#124 USE OF GENE EXPRESSION CHANGES IN<br />
CIRCULATING BLOOD CELLS TO MONITOR<br />
XENOESTROGEN EXPOSURE IN NEONATAL<br />
MICE. F. Lim, K. Antrobus, D. J. Moore, H. Tinwell, I.<br />
Kimber, J. Ashby, G. Orphanides and J. Moggs.<br />
Syngenta CTL, Macclesfield, Cheshire, United<br />
Kingdom.<br />
#125 COMPARISON OF WHOLE BLOOD GENE<br />
EXPRESSION PROFILES FROM THREE NON-<br />
HUMAN PRIMATE SPECIES AND HUMANS. C.<br />
S. Phillips and J. F. Dillman. Applied Pharmacology,<br />
USAMRICD, Aberdeen Proving Ground, MD. Sponsor:<br />
A. Sciuto.<br />
#126 THE BIOLOGY OF DRUG SIGNATURES. C.<br />
Pearson, R. Brennan, M. Fielden, B. Ganter, W. Hu, S.<br />
Tugendreich, A. Vladimirova and K. Kolaja. Iconix<br />
Pharmaceuticals, Inc., Mountain View, CA.<br />
#127 GENE EXPRESSION ANALYSIS OFFERS<br />
UNIQUE ADVANTAGES TO HISTOPATHOLOGY<br />
IN PREDICTION OF OVERALL LIVER<br />
CONDITION. A. N. Heinloth 1 , G. A. Boorman 2 and R.<br />
S. Paules 1 . 1 NCT, NIEHS, Research Triangle Park, NC<br />
and 2 ETP, NIEHS, Research Triangle Park, NC.<br />
58<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#128 CHANGES IN GENE EXPRESSION INDUCED BY<br />
TECHNICAL CHLORDANE, CIS-NONACHLOR,<br />
TRANS-NONACHLOR AND OXYCHLORDANE<br />
IN RAT LIVERS MONITORED BY<br />
OLIGONUCLEOTIDE MICRO-ARRAYS.<br />
CURRAN, I.H.A., HIERLIHY, A., AND BONDY, G.,<br />
TOXICOLOGY RESEARCH DIVISION, FOOD<br />
DIRECTORATE, HPFB, HEALTH CANADA,<br />
OTTAWA, ONTARIO, CANADA. I. Curran, A.<br />
Hierlihy and G. Bondy. <strong>Toxicology</strong> Research Division,<br />
Food Directorate, Health Canada, Ottawa, ON, Canada.<br />
Sponsor: G. Bondy.<br />
#129 EFFECT OF REPRODUCTIVE TOXICANTS ON<br />
GENE EXPRESSION IN THE RAT TESTES. T.<br />
Fukushima 1,2 , T. Yamamoto 1 , R. Kikkawa 1 , Y.<br />
Hamada 1 , I. Horii 1 and C. Mori 2 . 1 Worldwide Safety<br />
Sciences, Pfizer Global and Research Nagoya<br />
Laboratories, Taketoyo, Aichi, Japan and<br />
2 Bioenvironmental Medicine, Chiba University, Chiba,<br />
Japan. Sponsor: M. Kurata.<br />
#130 GENE EXPRESSION CHANGES IN FETAL<br />
THYMUS EXPOSED TO ORGANIC<br />
COMPOUNDS EXTRACTED FROM DIESEL<br />
EXHAUST PARTICLES. T. Ito 1 , H. Nagai 1,2 , T. Lin 3 ,<br />
R. E. Peterson 3 , C. Tohyama 1 , T. Kobayashi 1 and K.<br />
Nohara 1 . 1 National Institute for Environmental Studies,<br />
Tsukuba, Japan, 2 Science University <strong>of</strong> Tokyo, Noda,<br />
Japan and 3 University <strong>of</strong> Wisconsin, Madison, WI.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: ARSENIC AND URANIUM TOXICOLOGY<br />
Chairperson(s): John P. Christopher, CAL-EPA, Sacramento, CA and David<br />
S. Barber, University <strong>of</strong> Florida, Gainesville, FL.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#131 MOLECULAR CLONING AND<br />
CHARACTERIZATION OF HUMAN CYT19, AN<br />
S-ADENOSYL-L-METHIONINE:AS-<br />
METHYLTRANSFERASE FROM HEPG2 CELLS.<br />
A. McNally and D. Barber. University <strong>of</strong> Florida,<br />
Gainesville, FL.<br />
#132 GLOBAL CHANGES IN POSTTRANSLATIONAL<br />
COVALENT HISTONE MODIFICATIONS<br />
MEDIATED BY LOW-DOSE ARSENIC. J. F.<br />
Reichard and A. Puga. Environmental Health,<br />
University <strong>of</strong> Cincinnati, Cincinnati, OH.<br />
#133 ARSENIC CAUSES DOSE-DEPENDENT<br />
ENHANCEMENT AND SUPPRESSION OF<br />
RETINOIC ACID RECEPTOR (RAR)-MEDIATED<br />
GENE ACTIVATION. J. C. Davey, L. Ingram, C.<br />
Batki, J. Lariviere and J. W. Hamilton. Pharmacology &<br />
<strong>Toxicology</strong>, Dartmouth Medical School, Hanover, NH.<br />
#134 ARSENITE INHIBITS CELL CYCLE<br />
PROGRESSION OF U937 MYELOID LEUKEMIA<br />
CELLS THROUGH INDUCTION OF CDC25A<br />
DEGRADATION. G. McCollum Lehmann and M. J.<br />
McCabe. University <strong>of</strong> Rochester, Rochester, NY.<br />
#135 MOLECULAR MECHANISMS UNDERLYING<br />
INHIBITION OF INSULIN-STIMULATED<br />
GLUCOSE UPTAKE IN ADIPOCYTES EXPOSED<br />
TO TRIVALENT ARSENICALS. D. S. Paul, A. W.<br />
Harmon and M. Styblo. Department <strong>of</strong> Nutrition,<br />
University <strong>of</strong> North Carolina, Chapel Hill, NC.<br />
#136 FURTHER STUDIES ON ABERRANT GENE<br />
EXPRESSION IN ARSENIC-INDUCED<br />
MALIGNANT TRANSFORMATION OF LIVER<br />
EPITHELIAL CELLS. J. Liu 1 , L. Benbrahim-Tallaa 1 ,<br />
Y. Xie 1 , X. Qian 2 , W. Qu 1 , J. Otstot 3 and M. Waalkes 1 .<br />
1 Laboratory <strong>of</strong> Comparative Carcinogenesis, NCI at<br />
NIEHS, Research Triangle Park, NC, 2 LST, NIEHS,<br />
Research Triangle Park, NC and 3 DNA Sequencing<br />
Core, NIEHS, Research Triangle Park, NC.<br />
#137 ARSENITE DECREASES CYP3A INDUCTION IN<br />
CULTURED RAT HEPATOCYTES BY DUAL<br />
MECHANISMS. T. L. Noreault 1 , J. M. Jacobs 3,4 , R. C.<br />
Nichols 2,3 , H. W. Trask 4 , S. A. Wrighton 5 , P. R.<br />
Sinclair 1,2,4 , R. M. Evans 6 and J. F. Sinclair 1,2,4 .<br />
1 Pharmacology & <strong>Toxicology</strong>, Dartmouth Medical<br />
School, Hanover, NH, 2 VA Medical Center, White River<br />
Junction, VT, 3 Microbiology/Immunology, Dartmouth<br />
Medical School, Hanover, NH, 4 Biochemistry,<br />
Dartmouth Medical School, Hanover, NH, 5 Lilly<br />
Research Laboratories, Indianapolis, IN and 6 Howard<br />
Hughes Medical Institute, Salk Institute for Biological<br />
Studies, San Diego, CA.<br />
#138 ANALYSIS OF GLOBAL AND GENE SPECIFIC<br />
DNA METHYLATION IN LIVERS OF NEWBORN<br />
MICE TRANSPLACENTALLY EXPOSED TO A<br />
CARCINOGENIC DOSE OF ARSENIC. Y. Xie 1 , J.<br />
Liu 1 , L. Benbrahim-Tallaa 1 , B. Diwan 2 and M.<br />
Waalkes 1 . 1 Laboratory <strong>of</strong> Comparative Carcinogenesis,<br />
NCI at NIEHS, Research Triangle Park, NC and 2 BRP,<br />
SAIC-Frederick, NCI at Frederick, Frederick, MD.<br />
#139 ARSENITE INDUCES CYTOKERATIN<br />
EXPRESSION IN MICE LIVER. P. Ramirez 1 , M.<br />
Cerbon 2 and M. E. Gonsebatt 3 . 1 Laboratorio de<br />
Toxicologia Celular, FES Cuautitlan, Cuatitlan, Mexico,<br />
2 Biologia, Facultad de Quimica, UNAM, Mexico, DF,<br />
Mexico and 3 Medical Genomics and Environmental<br />
<strong>Toxicology</strong>, Instituto de Investigaciones Biomedicas,<br />
UNAM, Mexico, DF, Mexico.<br />
#140 REDUCTION OF ARSENATE BY HUMAN<br />
ERYTHROCYTE (RBC) LYSATE AND RAT<br />
LIVER CYTOSOL (CS) IS LINKED TO<br />
GLYCOLYSIS. B. Nemeti and Z. Gregus. Department<br />
Pharmacology, University Pecs, Med. School, Pecs,<br />
Hungary.<br />
#141 THE ROLE OF THE RAS SIGNALING PATHWAY<br />
IN ANDROGEN-INDEPENDENCE ACQUIRED<br />
DURING ARSENIC-INDUCED MALIGNANT<br />
TRANSFORMATION OF HUMAN PROSTATE<br />
EPITHELIAL CELLS. L. Benbrahim-Tallaa 1 , M.<br />
Webber 2 and M. Waalkes 1 . 1 Laboratory <strong>of</strong> Comparative<br />
Carcinogenesis, NCI at NIEHS, Research Triangle Park,<br />
NC and 2 Michigan State University, East Lansing, MI.<br />
#142 ARSENITE BINDING TO SUBSETS OF THE<br />
HUMAN ESTROGEN RECEPTOR-α. K. T. Kitchin<br />
and K. A. Wallace. Environmental Carcinogenesis<br />
Division, U.S. EPA, Research Triangle Park, NC.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 59
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#143 ALTERED PROTEIN EXPRESSION<br />
FOLLOWING IN UTERO EXPOSURE TO<br />
ARSENIC. C. Lantz, J. S. Petrick and A. M. Hays. Cell<br />
Biology and Anatomy, University <strong>of</strong> Arizona, Tucson,<br />
AZ.<br />
#144 ABERRANT GENE EXPRESSION IN THE<br />
NEONATAL MOUSE LUNG FOLLOWING IN<br />
UTERO EXPOSURE TO INORGANIC ARSENIC.<br />
J. Shen 1 , Y. Xie 1 , J. Liu 1 , B. Diwan 2 and M. Waalkes 1 .<br />
1 Laboratory <strong>of</strong> Comparative Carcinogenesis, NCI at<br />
NIEHS, Research Triangle Park, NC and 2 BRP, SAIC-<br />
Frederick, NCI at Frederick, Frederick, MD.<br />
#145 ARSENIC INDUCES CHROMOSOMAL AND<br />
CENTROMERIC ABNORMALITIES, IN HUMAN<br />
LUNG CELLS. J. P. Lynch 1,2 , S. S. Wise 1,2 and J. P.<br />
Wise 1,2 . 1 Wise Laboratory <strong>of</strong> Environmental and<br />
Genetic <strong>Toxicology</strong>, University <strong>of</strong> Southern Maine,<br />
Portland, ME and 2 Maine Center for <strong>Toxicology</strong> and<br />
Environmental Health, University <strong>of</strong> Southern Maine,<br />
Portland, ME.<br />
#146 CHARACTERIZATION OF HUMAN BLADDER<br />
UROTHELIAL CELLS MALIGNANTLY<br />
TRANSFORMED BY ARSENITE. K. E. Billings 1 , T.<br />
G. Bredfeldt 1 , X. H. Zheng 1 , M. J. Kopplin 1 , G. S.<br />
Watts 2 , D. A. Sens 4 , E. A. Mash 3 and A. J. Gandolfi 1 .<br />
1 Depts <strong>of</strong> Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong><br />
AZ, Tucson, AZ, 2 AZ Cancer Center, University <strong>of</strong> AZ,<br />
Tucson, AZ, 3 Department <strong>of</strong> Chemistry, University <strong>of</strong><br />
AZ, Tucson, AZ and 4 Depts <strong>of</strong> Pathology and Surgery,<br />
School <strong>of</strong> Medicine and Health Sciences, University <strong>of</strong><br />
ND, Grand Forks, ND.<br />
#147 ARSENITE AND MONOMETHYL ARSONOUS<br />
ACID-INDUCED TOXICITY IN HUMAN<br />
UROTHELIAL CELLS. T. G. Bredfeldt 1 , K. E.<br />
Billings 1 , X. H. Zheng 1 , E. A. Mash 2 , F. E. Domann 3 , S.<br />
S. Lau 1 , D. A. Sens 4 and A. J. Gandolfi 1 . 1 Pharmacology<br />
and <strong>Toxicology</strong>, University <strong>of</strong> AZ, Tucson, AZ,<br />
2 3 Chemistry, University <strong>of</strong> AZ, Tucson, AZ, Radiation<br />
Oncology, University <strong>of</strong> IA, Iowa City, IA and<br />
4 Pathology and Surgery, University <strong>of</strong> ND, Grand<br />
Forks, ND.<br />
#148 METABOLISM AND TOXICITY OF ARSENIC IN<br />
HUMAN URINARY BLADDER EPITHELIAL<br />
CELLS EXPRESSING RAT ARSENIC (+3)-<br />
METHYLTRANSFERASE. Z. Drobna 1 , S. B.<br />
Waters 2 , V. Devesa 3 , A. W. Harmon 1 , D. J. Thomas 4 and<br />
M. Styblo 1,3 . 1 Pediatrics, UNC Chapel Hill, NC, Chapel<br />
Hill, NC, 2 Curriculum in <strong>Toxicology</strong>, UNC, Chapel<br />
Hill, NC, 3 CEMALB, UNC, Chapel Hill, NC and<br />
4 NHEERL, U.S. EPA, Triangle Research Park, NC.<br />
#149 GLYCERALDEHYDE 3-PHOSPHATE<br />
DEHYDROGENASE (GAPDH) AS AN ARSENATE<br />
REDUCTASE IN HUMAN RED BLOOD CELLS<br />
(HRBC) AND RAT LIVER CYTOSOL (RLC). Z.<br />
Gregus and B. Nemeti. Department Pharmacology,<br />
University Pecs, Med. School, Pecs, Hungary.<br />
#150 ARSENITE INDUCES PROCOAGULANT<br />
ACTIVITY IN HUMAN PLATELETS BY<br />
PHOSPHATIDYLSERINE EXPOSURE AND<br />
MICROPARTICLE GENERATION. O. Bae, K. Lim<br />
and J. Chung. College <strong>of</strong> Pharmacy, Seoul National<br />
University, Seoul, South Korea.<br />
#151 ARSENIC METHYLTRANSFERASE CYT19<br />
EXPRESSION AND ACTIVITY IN RAT TISSUES.<br />
Y. Kobayashi 1,2 , T. Hayakawa 1 and S. Hirano 1 .<br />
1 Environmental Health Sciences Division, National<br />
Institute for Environmental Studies, Tsukuba, Ibaraki,<br />
Japan and 2 Japan Foundation for Aging and Health,<br />
Chita, Aichi, Japan.<br />
#152 THE ROLE OF VALENCE AND METHYLATION<br />
STATE ON THE ACTIVITY OF ARSENIC<br />
DURING MITOSIS. A. D. Kligerman, C. L. Doerr and<br />
A. H. Tennant. Environmental Carcinogenesis Division,<br />
U.S. EPA, Research Triangle Park, NC. Sponsor: D.<br />
Wolf.<br />
#153 INORGANIC ARSENIC BIOTRANSFORMATION<br />
AND MMA(V) REDUCTASE/GSTO1-1<br />
KNOCKOUT MICE. U. K. Chowdhury, R. A.<br />
Zakharyan, M. D. Avram, M. Wollenberg, A.<br />
Hernandez, M. Kopplin and H. V. Aposhian. Molecular<br />
and Cellular Biology, University <strong>of</strong> Arizona, Tucson,<br />
AZ.<br />
#154 DETERMINATION OF TRANSCRIPTION<br />
FACTORS IMPORTANT IN ARSENIC-INDUCED<br />
ALTERATIONS IN GENE EXPRESSION. A. Hays 1 ,<br />
R. Pandey 2 , R. Ahmed 1 , A. S. Andrew 3 , J. W. Hamilton 3<br />
and C. Lantz 1 . 1 Cell Biology and Anatomy, University<br />
<strong>of</strong> Arizona, Tucson, AZ, 2 Arizona Cancer Center,<br />
University <strong>of</strong> Arizona, Tucson, AZ and 3 Pharmacology<br />
& <strong>Toxicology</strong>, Dartmouth Medical School, Hanover,<br />
NH.<br />
#155 ARSENIC IN SEAFOOD: WHAT PERCENTAGE<br />
OF THE TOTAL IS INORGANIC ARSENIC? L. L.<br />
Chappell 1 , J. Colman 1 , R. M. Lorenzana 3 , P. McGinnis 2 ,<br />
R. Troast 4 and A. Yeow 4 . 1 Environ Sciences Ctr,<br />
Syracuse Research Corp, Syracuse, NY, 2 Syracuse<br />
Research Corp, Philadelphia, PA, 3 ORD Region 10,<br />
U.S. EPA, Seattle, WA and 4 OSRTI, U.S. EPA,<br />
Washington, DC.<br />
#156 ASSESSMENT OF EXPOSURE TO ARSENIC AND<br />
LIFE STYLE IN KOREAN. J. Park 1 , W. Lee 1 , M.<br />
Choi 4 , E. Park 2 , K. Park 3 and S. Kim 3 . 1 Preventive<br />
Medicine, Chung-Ang University, Seoul, South Korea,<br />
2 Pathology, Chung-Ang University, Seoul, South Korea,<br />
3 Advanced Analysis Center, Korea Institute <strong>of</strong> Science<br />
and Technology, Seoul, South Korea and 4 Chung-Un<br />
University, Chung-Un, South Korea.<br />
#157 URANYL ACETATE INDUCED OXIDATIVE<br />
STRESS IN CHINESE HAMSTER OVARY AA8<br />
CELLS: EFFECT ON DNA OXIDATION. J.<br />
Orozco 1 , A. M. Hays 1 , M. Yazzie 2 , D. M. Stearns 2 and<br />
C. Lantz 1 . 1 Cell Biology and Anatomy, University <strong>of</strong><br />
Arizona, Tucson, AZ and 2 Department <strong>of</strong> Chemistry and<br />
Biochemistry, Northern Arizona University, Flagstaff,<br />
AZ.<br />
#158 THE HPRT SPECTRA OF SPONTANEOUS,<br />
URANYL-ACETATE- AND HYDROGEN-<br />
PEROXIDE-INDUCED HPRT MUTANTS IN<br />
CHINESE HAMSTER OVARY EM9 CELLS. V. H.<br />
Coryell and D. M. Stearns. Chemistry and<br />
Biochemistry, Northern Arizona University, Flagstaff,<br />
AZ.<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#159 CYTOTOXICITY, GENOTOXICITYAND<br />
MUTAGENICITY OF COMBINED EXPOSURES<br />
OF URANYL ACETATE AND SODIUM<br />
ARSENITE IN CHO CELLS. Y. Monica 1 , W. H.<br />
Johnson 1 , J. T. Shelley 1 , H. M. Allison 2 , R. C. Lantz 2<br />
and D. M. Stearns 1 . 1 Chemistry and Biochemistry,<br />
Northern Arizona University, Flagstaff, AZ and 2 Cell<br />
Biology and Anatomy, University <strong>of</strong> Arizona, Tucson,<br />
AZ.<br />
#160 GENOTOXICITY OF PARTICULATE URANIUM<br />
AND CHROMIUM. S. S. Wise 1,2 , A. L. Holmes 1,2 , J.<br />
A. Moreland 1,2 and J. P. Wise 1,2 . 1 Wise Laboratory <strong>of</strong><br />
Environmental and Genetic <strong>Toxicology</strong>, University <strong>of</strong><br />
Southern Maine, Portland, ME and 2 Maine Center for<br />
<strong>Toxicology</strong> and Environmental Health, University <strong>of</strong><br />
Southern Maine, Portland, ME.<br />
#161 NEPHROTOXIC EFFECTS OF DEPLETED<br />
URANIUM (DU) IN THE RAT. INTERACTIONS<br />
WITH STRESS. L. Tobias 1 , D. Barber 2 , K.<br />
Zimmerman 1 , S. Hancock 1 , J. Hinckley 1 , M. Ehrich 1<br />
and B. S. Jortner 1 . 1 Virginia Tech, Blacksburg, VA and<br />
2 University <strong>of</strong> Florida, Gainesville, FL.<br />
#162 BIOLOGIC EFFECTS AFTER BRIEF<br />
INHALATION EXPOSURE TO URANIUM OXIDE<br />
OR DEPLETED URANIUM OXIDE AEROSOLS.<br />
F. F. Hahn 1 , E. B. Barr 1 , G. Bench 2 , J. Karlsson 3 and J.<br />
Lewis 3 . 1 Lovelace Respiratory Research Institute,<br />
Albuquerque, NM, 2 LLNL, Livermore, CA and<br />
3 University <strong>of</strong> New Mexico, Albuquerque, NM.<br />
#163 RENAL BIOMARKER RESULTS IN DEPLETED<br />
URANIUM (DU) EXPOSED GULF WAR<br />
VETERANS. M. A. McDiarmid 1,2 and K. Squibb 1,2 .<br />
1 Occupational Health, University <strong>of</strong> Maryland Medical<br />
Center, Baltimore, MD and 2 Depleted Uranium<br />
Followup <strong>Program</strong>, VA Maryland Health Care System,<br />
Baltimore, MD.<br />
#164 ASSESSING THE RENAL TOXICITY OF<br />
DEPLETED URANIUM AND OTHER URANIUM<br />
COMPOUNDS. L. E. Roszell 1 , F. F. Hahn 2 and R. B.<br />
Lee 1 . 1 US Army Center for Health Promotion and<br />
Preventive Medicine, Aberdeen Proving Ground, MD<br />
and 2 Lovelace Respiratory Research Institute,<br />
Albuquerque, NM.<br />
#165 UTILITY OF PATIENT MAILED URINE<br />
SPECIMENS FOR RENAL BIOMARKER<br />
ANALYSIS IN DEPLETED URANIUM (DU)<br />
EXPOSED 1991 GULF WAR VETERANS. K. S.<br />
Squibb 1,2 , M. Oliver 1,2 , P. Gucer 1,2 , S. Engelhardt 2,1 and<br />
M. McDiarmid 1,2 . 1 <strong>Program</strong> in <strong>Toxicology</strong>, University<br />
<strong>of</strong> Maryland School <strong>of</strong> Medicine, Baltimore, MD and<br />
2 Depleted Uranium <strong>Program</strong>, VA Maryland Health Care<br />
System, Baltimore, MD.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: IMMUNOTOXICOLOGY–METHODS AND<br />
SAFETY EVALUATION<br />
Chairperson(s): Danuta Herzyk, GlaxoSmithKline, Safety Assessment<br />
Immunotoxicology, King <strong>of</strong> Prussia, PA and Kimber White, Virginia<br />
Commonwealth University, Pharmacology and <strong>Toxicology</strong>, Richmond, VA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#166 NK CELL CYTOTOXICITY EVALUATION:<br />
TECHNICAL AND ANALYTICAL<br />
ALTERNATIVES TO CONVENTIONAL<br />
51 1 CHROMIUM RELEASE ASSAY. E. R. Gore , J.<br />
K. Gower 1 , E. Kurail 2 and D. J. Herzyk 1 . 1 Safety<br />
Assessment, GlaxoSmithKline, King <strong>of</strong> Prussia, PA and<br />
2 Statistical Sciences, GlaxoSmithKline, King <strong>of</strong> Prussia,<br />
PA.<br />
#167 ANTI-NKP46 IMPROVES DETECTION OF<br />
NATURAL KILLER CELLS IN MACAQUE<br />
BLOOD. W. Frings and G. Weinbauer. Covance<br />
Laboratories GmbH, 48163 Muenster, Germany.<br />
#168 IMMUNE SYSTEM DEVELOPMENT IN THE<br />
CYNOMOLGUS MONKEY: LYMPH NODES<br />
AND SPLEEN. G. Habermann, S. Friderichs-Gromoll,<br />
J. Kaspareit and E. Buse. Covance Laboratories GmbH,<br />
48163 Muenster, Germany. Sponsor: G. Weinbauer.<br />
#169 ANALYTICAL VALIDATION OF PERIPHERAL<br />
BLOOD IMMUNOPHENOTYPING FOR<br />
CYNOMOLGUS MONKEY. R. Caldwell, J. Fishel,<br />
G. Leatherberry and P. Marshall. Covance Laboratories,<br />
Madison, WI. Sponsor: P. Thomas.<br />
#170 IMMUNOGENICITY AND IMMUNOTOXICITY<br />
ASSESSMENTS OF TWO DRUG AFFINITY<br />
COMPLEX COMPOUNDS IN CYNOMOLGUS<br />
MONKEYS. S. Wen 1 , V. Iordanova 1 , C. N.<br />
Papagiannis 2 , M. Rebelatto 2 , T. Najarian 1 and J.<br />
Castaigne 1 . 1 ConjuChem, Inc., Montreal, QC, Canada<br />
and 2 MPI Research, Inc., Mattawan, MI. Sponsor: J.<br />
Daniels.<br />
#171 DEVELOPMENT AND VALIDATION OF SEMI-<br />
QUANTITATIVE ASSAYS FOR TOTAL AND<br />
NEUTRALIZING PRIMATE ANTIBODIES<br />
AGAINST A HUMAN THERAPEUTIC<br />
MONOCLONAL ANTIBODY. X. Guo 1 , D. Finco-<br />
Kent 1 , C. Soderstrom 1 , B. Cohen 1 , H. Wang 1 and T.<br />
Kawabata 1 . 1 Pfizer Inc., Groton, CT and 2 Pfizer Inc.,<br />
Groton, CT.<br />
#172 TEMPORAL STABILITY OF WHOLE BLOOD<br />
AND MONONUCLEAR CELL CULTURES TO<br />
SUPPORT LYMPHOCYTE PROLIFERATION<br />
FOLLOWING MITOGEN AND RECALL<br />
ANTIGEN STIMULATION. M. Wing, S. Wilkins, J.<br />
Hubbard and K. Gilbert. Huntingdon Life Sciences Ltd.,<br />
Huntingdon, United Kingdom. Sponsor: S. Dean.<br />
MONDAY<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#173 PERIPHERAL LYMPH NODES: ISSUES WITH<br />
THE COLLECTION AND ANALYSIS FOR<br />
IMMUNOTOXICITY STUDIES. P. J. Haley 1 , L.<br />
Chouinard 2 , P. Ciaccio 1 , D. Ennulat 3 , L. Gore 3 , S.<br />
Emeigh Hart 1 and J. Lapointe 4 . 1 Global Safety<br />
Assessment, AstraZeneca, Wilmington, DE, 2 CTBR,<br />
Montreal, QC, Canada, 3 GlaxoSmithKline, King <strong>of</strong><br />
Prussia, PA and 4 Pfizer, Groton, CT.<br />
#174 VALIDATION OF A METHOD FOR THE<br />
DETECTION OF ANTI-PROTEIN-X IGG<br />
ANTIBODIES IN RAT AND DOG SERUM BY<br />
ENZYME LINKED IMMUNOSORBENT ASSAY<br />
(ELISA). M. Ionescu, N. Rouleau, G. Desilets, A.<br />
Michaux, M. Duchesneau and L. LeSauteur.<br />
Immunology, CTBR Bio-Research Inc., Senneville, QC,<br />
Canada.<br />
#175 THE REAL TIME MONITOR OF ANTIBODY-<br />
CELL BINDING BY BIOSENSOR ASSAY. K.<br />
Harada, N. Ohtake, S. Hayashi, E. Furukawa, Y.<br />
Kikuchi and J. Kawahara. Pharmaceutical Development<br />
Laboratories, Pharmaceutical Division, Kirin Brewery<br />
Co., Ltd.,, Maebashi-shi, Gunma, Japan. Sponsor: E.<br />
Weaver.<br />
#176 ADVANTAGE OF USING WHOLE SHEEP RED<br />
BLOOD CELLS VERSUS CELL MEMBRANE IN<br />
ELISA ASSAYS TO ASSESS<br />
IMMUNOSUPPRESSION IN VIVO. T. Tsuchiya, A.<br />
Minakawa, H. Watanabe, E. Ohta, M. Sasaki, T. Ikeda,<br />
K. Samura and M. Nishikibe. Tsukuba Safety<br />
Assessment Laboratories, Banyu Pharmaceutical Co.,<br />
Ltd.,, Tsukuba, Ibaraki, Japan. Sponsor: N. Imura.<br />
#177 AN ALTERNATIVE KLH-BASED PROTOCOL<br />
FOR THE SRBC PLAQUE-FORMING CELL<br />
ASSAY: DOSE RANGE FINDER STUDY. M. van<br />
Zijverden, E. Klein Koerkamp, P. van den Berg and A.<br />
Penninks. <strong>Toxicology</strong> and Applied Pharmacology, TNO<br />
Nutrition and Food Research, Zeist, Netherlands.<br />
Sponsor: V. Feron.<br />
#178 SENSITIVITY OF THE KEYHOLE LIMPET<br />
HEMOCYANIN (KLH) ELISA MODEL IS<br />
DIRECTLY RELATED TO DOSE USED FOR<br />
SENSITIZATION. V. L. Peachee 1,2 , C. M. Sheth 1 , A.<br />
M. Halpen 2 and K. L. White 1,2 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, Virginia Commonwealth University,<br />
Richmond, VA and 2 ImmunoTox, Inc., Richmond, VA.<br />
#179 EVALUATION OF T CELL RESPONSES TO<br />
KEYHOLE LIMPET HEMOCYANIN IN THE RAT<br />
MODEL. A. E. Hillegas, C. A. Genell, C. C. Maier and<br />
D. J. Herzyk. Safety Assessment, GlasxoSmithKline,<br />
King <strong>of</strong> Prussia, PA.<br />
#180 COMPARISON OF ANTIBODY TITER AND<br />
CONCENTRATION IN A RAT<br />
IMMUNOTOXICITY MODEL. J. R. Piccotti, J. D.<br />
Alvey, C. Y. Malinczak and R. M. Slim. Worldwide<br />
Safety Sciences, Pfizer Global Research &<br />
Development, Ann Arbor, MI. Sponsor: M. Bleavins.<br />
#181 THE UTILITY OF HOST RESISTANCE ASSAYS<br />
IN LEAD CANDIDATE SELECTION AND<br />
PHARMACEUTICAL SAFETY ASSESSMENT. S.<br />
Groom, C. Thompson and K. Rioux. <strong>Toxicology</strong>, CTBR,<br />
Senneville, QC, Canada.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SIGNAL TRANSDUCTION: KINASES<br />
Chairperson(s): Dennis Petersen, University <strong>of</strong> Colorado, Denver, CO.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#182 ALTERED SIGNAL TRANSDUCTION IN HUMAN<br />
KERATINOCYTES FOLLOWING EXPOSURE TO<br />
BI-FUNCTIONAL ALKYLATING AGENTS. G. D.<br />
Minsavage and J. F. Dillman. Applied Pharmacology<br />
Branch Army Medical Research Institute <strong>of</strong> Chemical<br />
Defense, Aberdeen Proving Ground, MD.<br />
#183 2, 4, 6-TRINITROTOLUENE CAUSES<br />
REDUCTION OF ENOS ACTIVITY BUT<br />
PHOSPHORYLATES ENOS THROUGH<br />
ACTIVATION OF PI3K/AKT SIGNALING IN<br />
ENDOTHELIAL CELLS. Y. sun and Y. Kumagai.<br />
Social and Environmental Medicine, University <strong>of</strong><br />
Tsukuba, Tsukuba, Ibaraki, Japan. Sponsor: A.<br />
Naganuma.<br />
#184 PROTEIN KINASE Cζ MEDIATES LPS<br />
ACTIVATION OF NUCLEAR FACTOR KAPPA B<br />
(NF-κB) IN KIDNEY EPITHELIAL CELLS. W. W.<br />
Polk, J. V. Kushleika, M. E. Ellis, P. L. Simmonds and J.<br />
S. Woods. Environmental and Occupational Health<br />
Sciences, University <strong>of</strong> Washington, Seattle, WA.<br />
#185 4-HYDROXYNONENAL-MEDIATED<br />
INHIBITION OF ERK-ELK-AP-1 SIGNALING. B.<br />
P. Sampey, J. A. Doorn and D. R. Petersen.<br />
Pharmaceutical Sciences, University <strong>of</strong> Colorado HSC,<br />
Denver, CO.<br />
#186 INORGANIC PHOSPHATE CONTROLS CELL<br />
GROWTH THROUGH AKT/MEK-MEDIATED<br />
ERK-DEPENDENT MNK1 TRANSLOCATION IN<br />
NORMAL HUMAN BRONCHIAL EPITHELIAL<br />
CELLS. S. Chang 1 , G. R. Beck 2 , K. Lee 3 , D. Cho 4 and<br />
M. Cho 1 . 1 Laboratory <strong>of</strong> <strong>Toxicology</strong>, College <strong>of</strong><br />
Veterinary Medicine, Seoul National University, Seoul,<br />
South Korea, 2 Laboratory <strong>of</strong> Cancer Prevention,<br />
National Cancer Institute, Frederick, MD, 3 Laboratory<br />
<strong>of</strong> MOlecular Oncology, Korea Institute <strong>of</strong> Radiological<br />
& Medical Sciences, Seoul, South Korea and<br />
4 Reproductive <strong>Toxicology</strong>, National Institute <strong>of</strong><br />
Toxicological Research, KFDA, Seoul, South Korea.<br />
#187 ACTIVATION OF THE TRANSCRIPTION<br />
FACTOR AP-1 BY 2, 2’4, 4’-<br />
TETRACHLOROBIPHENYL (TCB) INVOLVES<br />
EXTRACELLULAR SIGNAL-REGULATED<br />
KINASES (ERKS) ENHANCED EXPRESSION OF<br />
C-FOS PROTOONCOGENE AND IN RAT LIVER<br />
CELLS. G. Chen, B. V. Madhukar and B. Wood.<br />
Pediatrics/Human Development, Michigan State<br />
University, East Lansing, MI.<br />
62<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: METHODS AND DEVICES<br />
Chairperson(s): James Swenberg, University <strong>of</strong> North Carolina Chapel Hill,<br />
Chapel Hill, NC and Kenneth Cheever, NIOSH, Cincinnati, OH.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#188 EFFECT OF EXTRACTION TECHNIQUE, LONG-<br />
TERM STORAGE AND GENDER ON GENE<br />
EXPRESSION PROFILES OF HUMAN WHOLE<br />
BLOOD. S. Kim 1 , R. N. Murrell 2 , J. E. Schmid 3 , K. E.<br />
Thompson 3 , D. J. Dix 3 and J. C. Rockett 3 . 1 Curriculum<br />
in <strong>Toxicology</strong>, University <strong>of</strong> North Carolina, Chapel<br />
Hill, NC, 2 Environmental and Molecular <strong>Toxicology</strong>,<br />
North Carolina State University, Raleigh, NC and<br />
3 RTD/NHEERL/ORD, U.S. EPA, Research Triangle<br />
Park, NC.<br />
#189 NANBIOTECHNOLOGY: DEVICES TO<br />
QUANTIFY CELLS AND THEIR FUNCTIONS. R.<br />
T. Emeny, T. J. Zieziulewicz, N. Mishra, J. N. Turner<br />
and D. A. Lawrence. Wadsworth Center, Albany, NY.<br />
#190 A HEADSPACE PROCEDURE FOR THE<br />
QUANTIFICATION OF 1- AND 2-<br />
BROMOPROPANE IN HUMAN URINE. C.<br />
B’Hymer and K. L. Cheever. BHAB, NIOSH,<br />
Cincinnati, OH.<br />
#191 EVALUATION OF TEST PROCEDURES FOR<br />
THE QUANTIFICATION OF URINARY (2-<br />
METHOXYETHOXY)ACETIC ACID. K. L. Cheever<br />
and C. B’Hymer. Molecular and Genetic Monitoring,<br />
NIOSH, Cincinnati, OH.<br />
#192 AUTOMATIC BIOSENSOR ANALYZER FOR<br />
RAPID ASSAY OF NEUROPATHY TARGET<br />
ESTERASE (NTE) IN BLOOD. V. V. Malygin 1 , G. F.<br />
Makhaeva 1 , N. N. Strakhova 1 , L. V. Sigolaeva 2 , L. G.<br />
Sokolovskaya 2 , A. V. Eremenko 2 , I. N. Kurochkin 2 and<br />
R. J. Richardson 3 . 1 Institute <strong>of</strong> Physiologically Active<br />
Compounds RAS, Chernogolovka, Russian Federation,<br />
2 Faculty <strong>of</strong> Chemistry, M.V. Lomonosov Moscow State<br />
University, Moscow, Russian Federation and 3 EHS<br />
Department, <strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong><br />
Michigan, Ann Arbor, MI.<br />
#193 AN IMPROVED METHOD FOR THE<br />
QUANTITATION OF 8-HYDROXY-2’-<br />
DEOXYGUANOSINE IN BIOLOGICAL<br />
SAMPLES. A. M. Luke 1 , S. Liao 2 , G. Boysen 2 and J.<br />
A. Swenberg 1,2 . 1 Curriculum in <strong>Toxicology</strong>, University<br />
<strong>of</strong> North Carolina, Chapel Hill, NC and 2 Department <strong>of</strong><br />
Environmental Sciences and Engineering, University <strong>of</strong><br />
North Carolina, Chapel Hill, NC.<br />
#194 BIOLOGICAL SAMPLE ANALYSIS METHODS<br />
DEVELOPMENT AND VALIDATION FOR A<br />
TOXICOKINETIC STUDY OF BIS(2-<br />
CHLOROETHOXY)METHANE. B. L. Burback 1 , S.<br />
Hong 1 , J. D. Johnson 1 , S. W. Graves 1 , J. Merrill 1 and C.<br />
Smith 2 . 1 Chemistry Technical Center, Battelle,<br />
Columbus, OH and 2 NIEHS, Research Triangle Park,<br />
NC.<br />
#195 VALIDATION OF A METHOD FOR THE<br />
DETECTION OF ANTI-KEYHOLE LIMPET<br />
HEMOCYANIN (KLH) IGM ANTIBODIES IN<br />
THE NEONATAL/JUVENILE CD-1 MOUSE<br />
SERUM BY ENZYME-LINKED<br />
IMMUNOSORBENT ASSAY (ELISA). N. Rouleau,<br />
C. Gelinas and L. LeSauteur. Immunology, CTBR,<br />
Senneville, QC, Canada.<br />
#196 NANBIOTECHNOLOGY: GRATING-COUPLED<br />
SURFACE PLASMON RESONANCE (GCSPR), A<br />
CELL AND PROTEIN MICROARRAY<br />
PLATFORM FOR THE ANALYSIS OF<br />
TOXICANT EFFECTS. D. Unfricht 1 , A. Sweatt 1 , S.<br />
Fernandez 2 , G. Jin 1 , T. Zieziulewicz 3 , D. Lawrence 3 and<br />
M. A. Lynes 1 . 1 Molecular and Cell Biology, University<br />
<strong>of</strong> Connecticut, Storrs, CT, CT, 2 Ciencia, Inc., E.<br />
Hartford, CT and 3 Wadsworth Center, Albany, NY.<br />
#197 RAT KIDNEY INJURY MOLECULE-1 (RKIM-1)<br />
ELISA: A SENSITIVE ASSAY FOR EARLY<br />
DETECTION OF KIDNEY TUBULAR INJURY IN<br />
PRECLINICAL TOXICITY STUDIES. V. S. Vaidya,<br />
T. Ichimura and J. V. Bonventre. Renal, Brigham and<br />
Women’s Hospital, Harvard Medical School, Boston,<br />
MA.<br />
#198 ANALYSIS OF HYDROXYMETHYLVINYL<br />
KETONE DERIVED 1, N 2 -<br />
PROPANODEOXYGUANOSINE BY LC-MS/MS.<br />
M. W. Powley 1 , V. E. Walker 2 and J. A. Swenberg 1 .<br />
1 Environmental Sciences and Engineering, University<br />
<strong>of</strong> North Carolina, Chapel Hill, NC and 2 Lovelace<br />
Respiratory Research Institute, Albuquerque, NM.<br />
#199 DEVELOPMENT AND VALIDATION OF A<br />
BIOANALYTICAL METHOD FOR TUNGSTEN.<br />
D. Kracko 1 , R. Marr 1 , R. Arimoto 2 and J. McDonald 1 .<br />
1 <strong>Toxicology</strong>, Lovelace Respiratory Research Institute,<br />
Albuquerque, NM and 2 Carlsbad Environmental<br />
Monitoring and Research Center, Carlsbad, NM.<br />
Sponsor: J. Mauderly.<br />
#200 N-(2, 3, 4, 5, 6-<br />
PENTAFLUOROPHENYL)DITHIOCARBAMATE<br />
AS A SENSITIVE DERIVATIZING REAGENT<br />
FOR THE ESTIMATION OF EPOXIDES OF 1, 3-<br />
BUTADIENE AND OTHER PETROCHEMICAL<br />
ALKENES. R. M. Uppu. Environmental <strong>Toxicology</strong>,<br />
Southern University and A&M College, Baton Rouge,<br />
LA.<br />
#201 A LUMINESCENT METHOD FOR MEASURING<br />
DRUG-DEPENDENT CHANGES IN P-<br />
GLYCOPROTEIN ATPASE ACTIVITY. J. Cali, R.<br />
Bulliet and D. Ma. Promega Corp, Madison, WI.<br />
#202 COMPARISON OF CALUX BIOASSAY AND<br />
HRGC/MS CHEMICAL ANALYSIS FOR THE<br />
DIOXIN LEVEL IN ENVIRONMENTAL<br />
MATRICES. Y. Y. Sheen 1 , K. E. Joung 1 , K. N. Min 1 , J.<br />
S. Kim 1 , M. J. Seo 1 , S. Y. Yang 1 and Y. H. Chung 2 .<br />
1 Pharmacy, Ewha Womans University, Seoul, South<br />
Korea and 2 Water Research, National Institute <strong>of</strong><br />
Environmental Research, Incheon, South Korea.<br />
Sponsor: J. Chung.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 63
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#203 A METHOD FOR REPEATED JUGULAR-VEIN<br />
TOXICOKINETIC BLOOD SAMPLING IN<br />
CONSCIOUS, NON-CANNULATED RATS. R. E.<br />
Kubaszky, G. Washer, N. Galliard, J. Laliberte and H.<br />
M. Moldovan. General <strong>Toxicology</strong>, ITR Laboratories<br />
Canada, Baie d’Urfe (Montreal), QC, Canada.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: OXIDATIVE STRESS I<br />
Chairperson(s): Bhupendra Kaphalia, University Of Texas, Galveston, TX<br />
and Manisha Bagchi, Interhealth Research Center, Benicia, CA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#204 ELECTROSTATIC SURFACE CHARGE OF<br />
NANOPARTICLES ACTIVATES CNS<br />
MACROPHAGES (MICROGLIA). M. Pooler 1 , O.<br />
Makwana 1 , J. Carter 2 , I. Beck-Speier 3 , W. Kreyling 3<br />
and B. Veronesi 2 . 1 <strong>Toxicology</strong> <strong>Program</strong>, NCSU,<br />
Raleigh, NC, 2 NHEERL, U.S. EPA, Research Triangle<br />
Park, NC and 3 National Research Center for<br />
Environment and Health, GSF Research Center,<br />
Munich, Germany.<br />
#205 INCREASED REACTIVE OXYGEN SPECIES<br />
PRODUCTION AND METABOLIC<br />
ALTERATIONS IN MITOCHONDRIA OF<br />
EXPERIMENTAL DIABETIC RAT TISSUES. H.<br />
Raza 1,2 , S. K. Prabu 2 and N. G. Avadhani 2 .<br />
1 Biochemistry, UAE University, Al Ain, United Arab<br />
Emirates and 2 Animal Biology, University <strong>of</strong><br />
Pennsylvania, Philadelphia, PA.<br />
#206 FAILURE OF DIETARY VITAMIN E TO<br />
PREVENT DOXORUBICIN-INDUCED CARDIAC<br />
MITOCHONDRIONOPATHY IN VIVO. J. M.<br />
Berthiaume 1 , P. Oliveira 2 , M. W. Fariss 3 and K. B.<br />
Wallace 1 . 1 Biochem. & Mol. Biology, <strong>Toxicology</strong><br />
Graduate <strong>Program</strong>, University <strong>of</strong> Minnesota, Duluth,<br />
MN, 2 Center for Neurosciences and Cell Biology,<br />
University <strong>of</strong> Coimbra, Coimbra, Portugal and<br />
3 Pharmaceutical Sciences and Cancer Center, University<br />
<strong>of</strong> Colorado Health Sciences Center, Denver, CO.<br />
#207 PRIMAQUINE-INDUCED HEMOLYTIC<br />
ANEMIA: ROLE OF SPLENIC MACROPHAGES,<br />
LIPID PEROXIDATION AND CYTOSKELETAL<br />
PROTEIN ALTERATIONS IN THE<br />
HEMOTOXICITY OF 5-<br />
HYDROXYPRIMAQUINE. Z. Bowman 1 , J. D.<br />
Morrow 2 , D. J. Jollow 1 and D. C. McMillan 1 . 1 Cell and<br />
Molecular Pharmacology, Medical University <strong>of</strong> South<br />
Carolina, Charleston, SC and 2 Department <strong>of</strong> Medicine,<br />
Vanderbilt University School <strong>of</strong> Medicine, Nashville,<br />
TN.<br />
#208 OXIDATIVE STRESS CAUSED BY<br />
GLUTATHIONE SYNTHESIS INHIBITOR<br />
BUTHIONINE SULFOXIMINE RESULTS IN<br />
GENOME REARRANGEMENTS IN MICE. R. H.<br />
Schiestl and R. Reliene. Pathology, Environmental<br />
Health and Radiation Oncology, UCLA, Los Angeles,<br />
CA.<br />
#209 INHIBITION OF HSP90α CHAPERONE<br />
ACTIVITY BY 4-HYDROXY-2-NONENAL. D. R.<br />
Petersen 1 , D. L. Carbone 1 , J. A. Doorn 2 and Z.<br />
Kiebler 1 . 1 University <strong>of</strong> Colorado Health Sciences<br />
Center, Denver, CO and 2 University <strong>of</strong> Iowa, Iowa City,<br />
IA.<br />
#210 HIGH FAT DIET DIFFERENTIALLY AND SITE-<br />
SPECIFICALLY ALTERS LUNG GLUTATHIONE<br />
AND ACUTE CYTOTOXICITY IN MALE AND<br />
FEMALE MICE. L. S. Van Winkle 1 , R. Stelck 1 , J.<br />
Graham 2 , K. Sutherland 1 , C. Brown 1 , J. Shimizu 1 , A.<br />
Buckpitt 3 , P. Havel 2 and G. Baker 1 . 1 VM:APC, UC<br />
Davis, Davis, CA, 2 Nutrition, UC Davis, Davis, CA and<br />
3 VM: Mol Biosci, UC Davis, Davis, CA.<br />
#211 MOLECULAR PATHOLOGICAL ANALYSIS OF<br />
HEPATOCARCINOGENESIS IN MICE TREATED<br />
WITH DICYCLANIL. M. moto 1 , T. Umemura 2 , M.<br />
Okamura 1 , Y. Kashida 1 , N. Machida 1 and K.<br />
Mitsumori 1 . 1 Tokyo University <strong>of</strong> Agriculture and<br />
Technology, Tokyo, Japan and 2 NIHS, Tokyo, Japan.<br />
Sponsor: M. takahashi.<br />
#212 ROLE OF NITRIC OXIDE IN DIESEL EXHAUST<br />
PARTICLE-INDUCED GENOTOXIC AND<br />
MUTAGENIC ACTIVITIES IN THE RAT LUNG. J.<br />
Y. Ma 1 , H. W. Zhao 1 , X. J. Yin 2 , M. W. Barger 1 , J. K.<br />
Ma 2 and V. Catranova 1 . 1 HELD, NIOSH, Morgantown,<br />
WV and 2 School <strong>of</strong> Pharmacy, West Virginia University,<br />
Morgantown, WV.<br />
#213 CONTRIBUTION OF REACTIVE OXYGEN<br />
SPECIES TO PARA-AMINOPHENOL-INDUCED<br />
CYTOTOXICITY. B. D. Foreman and J. B. Tarl<strong>of</strong>f.<br />
Pharmaceutical Sciences, University <strong>of</strong> the Sciences in<br />
Philadelphia, Philadelphia, PA.<br />
#214 ENVIRONMENTAL BASIS OF<br />
NEURODEGENERATION (ND) AND AGING:<br />
DIBROMOACETONITRILE (DBAN) INDUCES<br />
PROTEIN OXIDATION, INHIBITS<br />
PROTEASOMAL ACTIVITY AND ALTERS<br />
CYTOSOLIC PROTEOME IN NEUROGLIAL<br />
CELLS. A. E. Ahmed 1 , A. Kurosky 2 , J. R. Perez-Polo 2 ,<br />
B. Kurian 1 and S. Jacob 1 . 1 Pathology, University TX<br />
Medical Branch, Galveston, TX and 2 HBC&G,<br />
University TX Medical Branch, Galveston, TX.<br />
#215 AGE-RELATED ALTERATIONS IN KAINIC<br />
ACID-INDUCED NEURONAL OXIDATIVE<br />
DAMAGE. D. Milatovic 1 , S. Zaja-Milatovic 1 , R. C.<br />
Gupta 2 and T. J. Montine 1 . 1 Pathology, University <strong>of</strong><br />
Washington, Seattle, WA and 2 <strong>Toxicology</strong>, Murray State<br />
University, Hipkinsville, KY.<br />
#216 PROTECTIVE EFFECTS OF TAURINE AGAINST<br />
REACTIVE OXYGEN SPECIES IN ARPE-19<br />
CELLS. M. Tsang and R. Tchao. Department <strong>of</strong><br />
Pharmaceutical Sciences, University <strong>of</strong> the Sciences in<br />
Philadelphia, Philadelphia, PA. Sponsor: J. Tarl<strong>of</strong>f.<br />
64<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#217 INDUCTION OF INFLAMMATORY MEDIATORS<br />
AND ANTIOXIDANTS FOLLOWING EXPOSURE<br />
OF MACROPHAGES TO PARAQUAT. R.<br />
Mukhopadhyay 1 , J. P. Gray 1 , D. E. Heck 2 , A. T. Black 1 ,<br />
V. M. Mishin 2 , M. Thiruchelvam 1 , D. A. Cory-Slechta 1<br />
and J. D. Laskin 1 . 1 Environmental and Occupational<br />
Medicine, UMDNJ-Robert W Johnson Med. School,<br />
Piscataway, NJ and 2 Pharmacology and <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ.<br />
#218 ASCORBATE INHIBITS UROPORPHYRIA IN<br />
ASCORBATE-REQUIRING MICE. P. R. Sinclair 1,2 ,<br />
N. Gorman 1,2 , H. W. Trask 1,2 , A. Zaharia 1,2 and J. F.<br />
Sinclair 1,2 . 1 Research, VA Med. Ctr, White River<br />
Junction, VT and 2 Biochem/Pharmacol-Toxicol,<br />
Dartmouth Med. School, Hanover, NH.<br />
#219 DETERMINATION OF PARAMETERS<br />
INDICATIVE FOR OXIDATIVE STRESS IN<br />
CARBON TETRACHLORIDE TREATED RATS. P.<br />
Sagelsdorff 1 and Y. Balduchelly 2 . 1 Mechanistic<br />
<strong>Toxicology</strong>, RCC Ltd., Fuellinsdorf, Switzerland and<br />
2 Chimie, HEVs, Sion, Switzerland. Sponsor: K.<br />
Sachsse.<br />
#220 6-HYDROXYDOPAMINE ACTIVATES THE<br />
ANTIOXIDANT RESPONSE ELEMENT<br />
THROUGH A COMBINATION OF OXIDATIVE,<br />
EXCITOTOXIC, AND STRUCTURAL FACTORS.<br />
R. J. Jakel 1,2,3 , J. T. Kern 3 , D. A. Johnson 3 and J. A.<br />
Johnson 1,3 . 1 Neuroscience Training <strong>Program</strong>, University<br />
<strong>of</strong> Wisconsin, Madison, WI, 2 Medical Scientist Training<br />
<strong>Program</strong> and UW Medical School, University <strong>of</strong><br />
Wisconsin, Madison, WI and 3 Pharmaceutical Sciences,<br />
University <strong>of</strong> Wisconsin, Madison, WI.<br />
#221 ACTIVATION OF TRANSCRIPTION FACTOR<br />
AP-1 IN ANILINE-INDUCED SPELENIC<br />
TOXICITY. S. -. Kannan, J. -. Wang and M. Khan.<br />
Pathology, Univesrity <strong>of</strong> Texas Medical Branch,<br />
Galveston, TX.<br />
#222 DOWN-REGULATION OF NITRIC OXIDE AND<br />
ANTIOXIDANT SYSTEMS IN ALCOHOL-<br />
INDUCED HYPERTENSION. K. Husain, J. Lalla and<br />
S. Kazim. Pharmacology and <strong>Toxicology</strong>, Ponce School<br />
<strong>of</strong> Medicine, Ponce, Puerto Rico.<br />
#223 HO-1 INDUCTION CONTRIBUTES TO PCB-<br />
INDUCED OXIDATIVE STRESS IN<br />
DOPAMINERGIC CELLS. D. W. Lee, R. M. Gelein<br />
and L. A. Opanashuk. Department <strong>of</strong> Environmental<br />
Medicine, University <strong>of</strong> Rochester School <strong>of</strong> Medicine<br />
and Dentistry, Rochester, NY.<br />
#224 REACTIVE OXYGEN/NITROGEN SPECIES IN<br />
ACETAMINOPHEN (APAP) TOXICITY IN<br />
FRESHLY ISOLATED MOUSE HEPATOCYTES.<br />
A. B. Reid and J. A. Hinson. Pharmacology, University<br />
<strong>of</strong> Arkansas for Medical Sciences, Little Rock, AR.<br />
#225 ACETAMINOPHEN INDUCED HEPATOXICITY<br />
IN A GCLM- NULL MOUSE MODEL. L.<br />
McConnachie 1 , C. Fernandez 1 , I. Mohar 1 , R. Pierce 2<br />
and T. Kavanagh 1 . 1 Department <strong>of</strong> Environmental and<br />
Occupational Health Sciences, University <strong>of</strong><br />
Washington., Seattle, WA and 2 Department <strong>of</strong> Pathology<br />
and Lab. Medicine, University <strong>of</strong> Rochester, Rochester,<br />
NY.<br />
#226 INDUCTION OF METALLOTHIONEIN<br />
SYNTHESIS MEDIATED THROUGH OXIDATIVE<br />
STRESS IN MITOCHONDRIA AND ITS<br />
BIOLOGICAL ROLE. M. Sato. Faculty <strong>of</strong> Pharmacy,<br />
Tokushima Bunri University, Tokushima, Japan.<br />
#227 HEPATOCYTE-SPECIFIC DELETION OF GCLC<br />
RESULTS IN PROGRESSIVE LOSS OF<br />
MITOCHONDRIAL FUNCTION. Y. Chen, D. Shen,<br />
H. G. Shertzer, M. L. Miller, S. N. Schneider, D. W.<br />
Nebert and T. P. Dalton. Environmental Health,<br />
University <strong>of</strong> Cincinnati Medical Center, Cincinnati,<br />
OH.<br />
#228 A NOVEL HALOENOL LACTONE DERIVATIVE<br />
INDUCES OXIDATIVE STRESS IN HUMAN<br />
TUMOR CELLS THROUGH A GLUTATHIONE S-<br />
TRANSFERASE MEDIATED MECHANISM. W.<br />
Wang and J. Zheng. Pharmaceutical Sciences,<br />
Northeastern University, Boston, MA.<br />
#229 IDENTIFICATION AND CHARACTERIZATION<br />
OF BIOACTIVE COMPOUNDS FROM TOBACCO<br />
AS INHIBITORS OF NEURONAL NITRIC OXIDE<br />
SYNTHASE. P. Venkatakrishnan 1 and T. R. Miller 1 .<br />
1 Graduate Center for <strong>Toxicology</strong>, University <strong>of</strong><br />
Kentucky, Lexington, KY and 2 Graduate Center for<br />
<strong>Toxicology</strong>, University <strong>of</strong> Kentucky, Lexington, KY.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: METHYL IODIDE RISK ASSESSMENT<br />
Chairperson(s): Michael Gargas, Sapphire Group Inc., Dayton, OH and Lisa<br />
Sweeney, The Sapphire Group, Dayton, OH.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#230 DEVELOPMENT AND VALIDATION OF AN<br />
ASSAY FOR IODIDE IN SERUM USING ION<br />
CHROMATOGRAPHY WITH AMPEROMETRIC<br />
DETECTION. E. Kaiser 1 , J. M. Flaherty 1 , M. W.<br />
Himmelstein 2 and J. H. Kinzell 3 . 1 Exygen Research,<br />
Inc., State College, PA, 2 DuPont Haskell Laboratory for<br />
Health and Environmental Sciences, Newark, DE and<br />
3 Arvesta Corporation, San Francisco, CA.<br />
#231 METHYLATION OF HEMOGLOBIN CYSTEINE<br />
AS A BIOMARKER OF EXPOSURE TO<br />
IODOMETHANE. D. L. Nabb 1 , M. W. Himmelstein 1 ,<br />
M. P. Delorme 1 , E. Sloter 3 , M. L. Gargas 2 , J. H.<br />
Kinzell 4 and R. A. Kemper 1 . 1 DuPont Haskell<br />
Laboratory, Newark, DE, 2 The Sapphire Group, Dayton,<br />
OH, 3 WIL Research Laboratories, Ashland, OH and<br />
4 Arvesta Corporation, San Fransisco, CA.<br />
#232 UPTAKE OF METHYL IODIDE IN THE NASAL<br />
CAVITY OF RATS AND RABBITS. K. D. Thrall 1 , A.<br />
D. Woodstock 1 , J. J. Soelberg 1 , J. H. Kinzell 2 and M. L.<br />
Gargas 3 . 1 Battelle, Pacific Northwest Division,<br />
Richland, WA, 2 Arvesta Corp., San Francisco, CA and<br />
3 The Sapphire Group, Inc., Beavercreek, OH.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 65
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#233 SPECIES AND TISSUE COMPARISON OF THE<br />
GLUTATHIONE CONJUGATION OF METHYL<br />
IODIDE IN RAT, RABBIT, AND HUMAN<br />
CYTOSOL. T. Poet 1 , H. Wu 1 , J. Soelberg 1 , J. Kinzell 2<br />
and M. Gargas 3 . 1 Biological Monitoring and Modeling,<br />
Battelle, Richland, WA, 2 Arvesta Corp, San Francisco,<br />
CA and 3 The Sapphire Group, Inc., Beavercreek, OH.<br />
#234 IODOMETHANE: 2-DAY MECHANISTIC<br />
INHALATION EXPOSURE STUDY IN THE RAT.<br />
M. W. Himmelstein 1 , M. P. DeLorme 1 , R. A. Kemper 1 ,<br />
D. L. Nabb 1 , J. C. O’Connor 1 , M. L. Gargas 2 and J. H.<br />
Kinzell 3 . 1 DuPont Haskell Laboratory for Health and<br />
Environmental Sciences, Newark, DE, 2 The Sapphire<br />
Group, Dayton, OH and 3 Arvesta Corporation, San<br />
Francisco, CA.<br />
#235 EVALUATION OF RESPIRATORY PARAMETERS<br />
IN RATS AND RABBITS EXPOSED TO<br />
IODOMETHANE. M. DeLorme 1 , M. W. Himmelstein 1 ,<br />
M. L. Gargas 2 and J. H. Kinzell 3 . 1 DuPont Haskell<br />
Laboratory, Newark, DE, 2 The Sapphire Group, Dayton,<br />
OH and 3 Aresta Corporation, San Francisco, CA.<br />
#236 IODOMETHANE PARTITION COEFFICIENTS<br />
IN RAT AND RABBIT TISSUES AND HUMAN<br />
BLOOD. S. Gannon 1 , M. W. Himmelstein 1 , L. M.<br />
Sweeney 2 , M. L. Gargas 2 and J. H. Kinzell 3 . 1 Dupont<br />
Haskell Laboratory for Health and Environmental<br />
Sciences, New Castle, DE, 2 The Sapphire Group,<br />
Dayton, OH and 3 Arvesta Corporation, San Francisco,<br />
CA.<br />
#237 DERIVATION OF HUMAN TOXICITY<br />
REFERENCE VALUES FOR METHYL IODIDE<br />
USING PBPK MODELING. L. M. Sweeney 1 , J. H.<br />
Kinzell 2 and M. L. Gargas 1 . 1 The Sapphire Group,<br />
Dayton, OH and 2 Arvesta Corporation, San Francisco,<br />
CA.<br />
#238 THE DISPOSITION AND PHARMACOKINETICS<br />
OF RADIOIODIDE IN PREGNANT RABBITS<br />
AND FETUSES. J. E. Morris 1 , L. B. Sasser 1 , J. A.<br />
Creim 1 , L. K. Fritz 1 , K. D. Thrall 1 , J. H. Kinzell 2 and<br />
M. L. Gargas 3 . 1 Battelle, Pacific Northwest Division,<br />
Richland, WA, 2 Arvesta Corp., San Francisco, CA and<br />
3 The Sapphire Group, Beavercreek, OH.<br />
#239 PRENATAL DEVELOPMENTAL TOXICITY<br />
STUDIES IN RABBITS REVEAL A SUSCEPTIBLE<br />
WINDOW OF METHYL IODIDE-INDUCED<br />
FETOTOXICITY LATE IN GESTATION. M. D.<br />
Nemec 1 , E. D. Sloter 1 , J. F. Holson 1 , D. G. Stump 1 and<br />
J. Kinzell 2 . 1 WIL Research Laboratories, Inc., Ashland,<br />
OH and 2 Arvesta Corporation, San Francisco, CA.<br />
#240 METHYL IODIDE-INDUCED<br />
HYPOTHYROIDISM IN FETAL RABBITS. E. D.<br />
Sloter 1 , M. D. Nemec 1 , R. Baumgartner 1 , J. F. Holson 1 ,<br />
M. Gargas 2 and J. Kinzell 3 . 1 WIL Research<br />
Laboratories, Inc., Ashland, OH, 2 The Sapphire Group,<br />
Inc., Beavercreek, OH and 3 Arvesta Corporation, San<br />
Francisco, CA.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: REGULATORY/POLICY<br />
Chairperson(s): Abdel-Razak Kadry, OPHS/USDA/FSIS, Washington, DC and<br />
Timothy McMahon, U.S. EPA, Washington, DC.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#241 QUANTITATIVE ASSESSMENT OF DERMAL<br />
SENSITIZATION RISK FROM TREATED<br />
ARTICLES: HEXAVALENT CHROMIUM (CRVI)<br />
AS A CASE STUDY. T. McMahon and J. Chen. U.S.<br />
EPA, Washington, DC.<br />
#242 THE USE OF RISK ASSESSMENT IN<br />
EVALUATING FOOD BIOSECURITY OPTIONS.<br />
A. M. Kadry 1 , C. Maczka 2 , P. Santiago 2 and L. Borghi 3 .<br />
1 Risk Assessement Division, OPHS/USDA/FSIS,<br />
Washington, DC, 2 OFSEP/USDA/FSIS, Washington,<br />
DC and 3 Science Applications International<br />
Corporation, Germantown, MD.<br />
#243 MYCOTOXIN RISK ASSESSMENT FOR THE<br />
PURPOSE OF SETTING INTERNATIONAL<br />
REGULATORY STANDARDS. F. Wu. Environmental<br />
& Occupational Health, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA. Sponsor: M. Karol.<br />
#244 ASSESSMENT OF THE TOXICOLOGICAL RISK<br />
OF CHEMICAL MIXTURES AT WORKPLACE. A.<br />
Vyskocil 1 , D. Drolet 2 , C. Viau 1 , F. Lemay 2 , G.<br />
Lapointe 3 , R. Tardif 1 , G. Truchon 2 , M. Baril 2 , N.<br />
Gagnon 3 , D. Begin 1 and M. Gerin 1 . 1 Environmental and<br />
Occupational Health, University <strong>of</strong> Montreal, Montreal,<br />
QC, Canada, 2 IRSST, Montreal, QC, Canada and<br />
3 CSST, Montreal, QC, Canada.<br />
#245 SCIENTIFIC PEER REVIEW TO INFORM<br />
REGULATORY DECISION-MAKING:<br />
LEADERSHIP RESPONSIBILITIES AND<br />
CAUTIONS. D. Patton 1,2 and S. Olin 1 . 1 Risk Science<br />
Institute, International Life Sciences Institute,<br />
Washington, DC and 2 Consultant, Washington, DC.<br />
Sponsor: P. Fenner-crisp.<br />
#246 A STRATEGY FOR THE SELECTION OF THE<br />
NON-RODENT IN REGULATORY<br />
PHARMACEUTICAL TOXICITY TESTING. J.<br />
Burnett and J. Gardner. Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom. Sponsor: D. Everett.<br />
#247 CIRCADIAN VARIATION IN FEEDING<br />
BEHAVIOUR OF RODENTS RECEIVING<br />
POWDERED DIET ON REGULATORY<br />
TOXICITY STUDIES: 1) THE MOUSE. D. Everett,<br />
R. Jones and F. Halleema. Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom.<br />
66<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: EDUCATION AND PUBLIC OUTREACH<br />
Chairperson(s): Daniel Petersen, U.S. EPA, Cincinnati, OH.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#248 ADDRESSING TOXICOLOGICAL CHALLENGES<br />
TO COMMUNITY WATER FLUORIDATION IN<br />
WASHINGTON STATE. D. Dodge, R. C. Pleus and<br />
M. K. Peterson. Intertox, Seattle, WA.<br />
#249 HOW STAFF GROW IN A CRO. L. K. Earl.<br />
<strong>Toxicology</strong> Consultancy, Huntingdon Life Sciences,<br />
Cambridgeshire, United Kingdom. Sponsor: C. Hardy.<br />
#250 PERCEPTION OF METHYLMERCURY RISK<br />
INFORMATION. D. D. Petersen 1,2 . 1 ORD, U.S. EPA,<br />
Cincinnati, OH and 2 Biology, University <strong>of</strong> Cincinnati,<br />
Cincinnati, OH.<br />
#251 TOXICOLOGY EDUCATION–TO LEARN OR TO<br />
TEACH? T. Malmfors. Malmfors Consulting AB,<br />
Johanneshov, Stockholm, Sweden.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CHILDRENS HEALTH AND JUVENILE ANIMAL<br />
TOXICOLOGY<br />
Chairperson(s): Susan Knadle, CAL-EPA, Sacramento, CA and Gonzalo<br />
Garcia-Vargas, Universidad Juarez del Estado de Durango, Gomez Palacio,<br />
Mexico.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#252 BLOOD LEAD, ANEMIA, AND SHORT STATURE<br />
ARE INDEPENDENTLY ASSOCIATED WITH<br />
COGNITIVE PERFORMANCE IN MEXICAN<br />
SCHOOL CHILDREN. G. G. Garcia-Vargas 1 , K.<br />
Kordaz 2 , M. Rubio-Andrade 1 , P. Lopez 3 , J. L. Rosado 4 ,<br />
J. Alatorre Rico 5 , D. Ronquillo 4 , M. E. Cebrian 6 and R.<br />
J. Stoltzfus 2 . 1 Facultad de Medicina., Universidad<br />
Juarez de Durango, Gomez Palacio, Durango, Mexico,<br />
2 Division Nutritional Sciences, Cornell University, New<br />
York, 3 Department Fisiologia Nutricion, Inst. Nal.<br />
Ciencias Medicas y Nutricion, Mexico, D. F., Mexico,<br />
4 Escuela de Ciencias Naturales, UAQ, Queretaro,<br />
Mexico, 5 Facultad de Psicologia, UNAM, Mexico, D.<br />
F., Mexico and 6 Depto Toxicologia, CINVESTAV-IPN,<br />
Mexico, D. F., Mexico.<br />
#253 LEAD EXPOSURE AS RISK FACTOR BY<br />
ALLERGY DISEASES IN MEXICAN<br />
CHILDHOOD. A PILOT STUDY. R. Goytia-<br />
Acevedo 1 , G. Rodriguez 1 , M. Meza-Velazquez 1 , E.<br />
Calderon-Aranda 2 , G. Garcia-Arenas 1 , G. Rosales 1 , M.<br />
Rubio-Andrade 1 , R. Candelas 1 and G. Garcia-Vargas 1 .<br />
1 Investigacion, Universidad Juarez Del Estado de<br />
Durango, Gomez Palacio, Durango, Mexico and<br />
2 Toxicologia, Centro de Investigacion y de Estudios<br />
Avanzados, DF, Mexico.<br />
#254 DEVELOPMENT OF CHILD-SPECIFIC<br />
REFERENCE VALUES FOR SCHOOL SITE RISK<br />
ASSESSMENT. S. Knadle 1 , D. W. Chan 1 , J. C.<br />
Carlisle 1 , K. E. Stewart 3 , C. A. Poole 2 , C. Vaughn 2 , S.<br />
Camacho 2 and D. M. Siegel 1 . 1 Cal/EPA, Sacramento,<br />
CA, 2 UC, Davis, CA and 3 U.S. EPA, S.F., CA.<br />
#255 ENVIRONMENTAL FACTORS AND PUBERTY<br />
TIMING: SUMMARY OF AN EXPERT PANEL<br />
WORKSHOP. S. Y. Euling 1 , S. G. Selevan 1 , O. H.<br />
Pescovitz 2 and N. E. Skakkebaek 3 . 1 NCEA-W, U.S.<br />
EPA, Washington, DC, 2 Pediatric<br />
Endocrinology/Diabetology, Indiana University,<br />
Indianapolis, IN and 3 University Department <strong>of</strong> Growth<br />
and Reproduction, Rigshospitalet, Copenhagen,<br />
Denmark. Sponsor: C. Kimmel.<br />
#256 BISPHENOL A EXPOSURE AND ENDOCRINE<br />
DISORDERS IN CHILDREN. M. Yang 1 , Y. Kim 1 , C.<br />
Shin 2 , S. Han 3 and M. Pyo 1 . 1 Pharmacy, Sookmyung<br />
Women’s University, Seoul, South Korea, 2 Pediatrics,<br />
Seoul National University, Seoul, South Korea and<br />
3 Urology, Yonsei University, Seoul, South Korea.<br />
#257 AN AGE-DEPENDENT HALF-LIFE MODEL FOR<br />
ESTIMATING CHILDHOOD BODY BURDENS<br />
OF DIBENZODIOXINS AND DIBENZOFURANS.<br />
B. D. Kerger 1 , H. W. Leung 2 , P. Scott 3 and D. J.<br />
Paustenbach 4 . 1 Health Science Resource Integration,<br />
Inc., Tallahassee, FL, 2 Private Consultant, Danbury, CT,<br />
3 4 ChemRisk, Pittsburgh, PA and ChemRisk, San<br />
Francisco, CA.<br />
#258 ARE THERE AGE RELATED DIFFERENCES IN<br />
CHILDRENS SUSCEPTIBILITY FOR<br />
DEVELOPING SECONDARY ACUTE<br />
MYELOGENOUS LEUKEMIA? D. Pyatt 1,2 , S.<br />
Hays 4 and C. Cushing 3 . 1 ChemRisk, Boulder, CO,<br />
2 MTEHS, University <strong>of</strong> Colorado Health Sciences<br />
Center, Denver, CO, 3 Exponent, Boulder, CO and<br />
4 Summit <strong>Toxicology</strong>, Lyons, CO.<br />
#259 PBPK MODELING OF INTER-CHILD<br />
DIFFERENCES IN PHARMACOKINETICS ON<br />
THE BASIS OF SUBJECT-SPECIFIC DATA ON<br />
HEPATIC CYP2E1 LEVELS. A. Nong 1 , D. G.<br />
McCarver 2 , R. Hines 2 and K. Krishnan 1 . 1 Occupational<br />
and Environmental Health, Universite de Montreal,<br />
Montreal, QC, Canada and 2 Medical College <strong>of</strong><br />
Wisconsin, Milwaukee, WI.<br />
MONDAY<br />
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44 th Annual Meeting<br />
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MONDAY<br />
#260 DEVELOPMENTAL EXPOSURE TO<br />
ENVIRONMENTAL ESTROGENS IS<br />
ASSOCIATED WITH OBESITY LATER IN LIFE.<br />
E. Padilla-Banks 1 , W. Jefferson 1,2 , R. Snyder 2 and R.<br />
Newbold 1 . 1 Laboratory <strong>of</strong> Molecular <strong>Toxicology</strong>,<br />
NIEHS, NIH/DHHS, Research Triangle Park, NC and<br />
2 Molecular and Evironmental <strong>Toxicology</strong> Department,<br />
NC State University, Raleigh, NC.<br />
#261 PHYSIOLOGICAL PARAMETERS FOR EARLY<br />
LIFE STAGES. S. Olin 1 , H. Clewell 2 , R. Gentry 2 and<br />
I. Working Group 1 . 1 Risk Science Institute, International<br />
Life Sciences Institute, Washington, DC and<br />
2 ENVIRON Health Sciences Institute, Ruston, LA.<br />
#262 NON-CLINICAL RODENT PEDIATRIC STUDIES<br />
AT CTBR: ASSESSMENT OF MORTALITY AND<br />
GROWTH. L. Pouliot, L. Pinsonneault, M. Adamo and<br />
K. Robinson. <strong>Toxicology</strong>, CTBR, Senneville, QC,<br />
Canada. Sponsor: M. Vezina.<br />
#263 AGE-RELATED DIFFERENCES IN<br />
SUSCEPTIBILITY TO TOXIC EFFECTS OF<br />
VALPROIC ACID IN RATS. P. Espandiari, T. Miller,<br />
A. Knapton, J. Zhang and J. Hanig. CDER, U.S. FDA,<br />
Silver Spring, MD.<br />
#264 ASSESSMENT OF HAZARD POTENTIAL AND<br />
RISK FOR ASTHMATIC RESPONSES<br />
FOLLOWING RESIDENTIAL EXPOSURE TO<br />
PHTHALATES. R. McKee, R. David, J. H. Butala, R.<br />
Parod and L. Navarro. Phthalate Esters Panel,<br />
Washington, DC.<br />
#265 BENZYL ALCOHOL: SAFETY ASSESSMENT IN<br />
JUVENILE RATS. O. Foulon, L. Mungapen, W.<br />
Gaoua and R. Forster. CIT, Evreux, France.<br />
#266 LIPID PEROXIDATION PRODUCT INDUCED<br />
GASTRIC GROWTH IN POSTNATAL RATS BY<br />
MODULATION OF SELECTED PROTEIN<br />
KINASES. P. C. Lee 1,2 . 1 Pediatrics, Medical College <strong>of</strong><br />
Wisconsin, Milwaukee, WI and 2 Pharmacology and<br />
<strong>Toxicology</strong>, Medical College <strong>of</strong> Wisconsin, Milwaukee,<br />
WI.<br />
#267 GENE EXPRESSION PROFILES OF THE<br />
ARTICULAR CARTILAGE IN JUVENILE RATS<br />
TREATED WITH THE QUINOLONE<br />
ANTIBACTERIAL AGENT OFLOXACIN. K.<br />
Goto 1 , K. Yabe 1 , S. Takada 1 , Y. Yamamoto 1 , H. Yokota 2 ,<br />
T. Jindo 1 and K. Furuhama 1 . 1 Drug Safety Research<br />
Laboratory, Daiichi Pharmaceutical Co., Ltd.,, Tokyo,<br />
Japan and 2 Proteome Research Laboratory, Daiichi<br />
Pharmaceutical Co., Ltd.,, Tokyo, Japan.<br />
#268 A NOVEL APPROACH TO GENERATE<br />
JUVENILE ANIMAL DATA DURING THE<br />
PRE/POSTNATAL RANGE FINDING STUDY IN<br />
THE RAT. L. M. De Schaepdrijver 1 , G. P. Bailey 1 , L.<br />
M. Burns 2 , J. Monbaliu 1 , P. Annaert 1 , T. P. Coogan 3 and<br />
W. Coussement 1 . 1 Johnson and Johnson Pharmaceutical<br />
Research & Development, Beerse, Belgium, 2 Sequani<br />
Limited, Ledbury, United Kingdom and 3 Johnson and<br />
Johnson Pharmaceutical Research and Development,<br />
Springhouse, PA.<br />
#269 IMPACT OF DOSE RATE ON NEUROTOXICITY<br />
OUTCOME IN CD RAT PUPS GIVEN THE N-<br />
METHYL-D-ASPARTATE (NMDA) RECEPTOR<br />
ANTAGONIST, MK-801. M. S. Marty, J. A.<br />
Hammond, A. J. Clark, D. Rick, J. Van Fleet, A. K.<br />
Andrus and J. P. Maurissen. <strong>Toxicology</strong> &<br />
Environmental Research, The Dow Chemical Company,<br />
Midland, MI.<br />
#270 COMPARATIVE DATA OF HAND-REARED AND<br />
MATERNALLY REARED INFANT<br />
CYNOMOLGUS MONKEYS FOR TOXICITY<br />
STUDIES. F. P. de Villa 1 , R. M. Perez 1 , T. Hayashi 1 , N.<br />
Muto 2 , M. Nomura 2 and H. Nakagawa 2 . 1 Ina Research<br />
Philippines, Inc., Binan Laguna, Philippines and 2 Ina<br />
Research Inc., Nagano, Japan.<br />
Monday Morning, March 7<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: DEVELOPMENTAL TOXICITY TESTING<br />
Chairperson(s): Christopher Lau, U.S. EPA, Research Triangle Park, NC and<br />
Gregg Cappon, Pfizer Global Research & Development, Groton, CT.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#271 INFLUENCE OF MATERNAL TOXICITY IN<br />
STUDIES ON DEVELOPMENTAL TOXICITY: A<br />
WORKSHOP REPORT. F. Welsch 1 and E. C.<br />
Hennes 2 . 1 Orbitox, Santa Fe, NM and 2 ECETOC,<br />
Brussels, Belgium.<br />
#272 TIME-MATED RABBITS WITH VASCULAR<br />
ACCESS PORT (VAP): A NOVEL APPROACH TO<br />
THE VASCULAR SYSTEM FOR SERIAL<br />
INFUSION OR REPETITIVE BLOOD<br />
COLLECTION. D. S. Broughton 1 , B. Fetter 2 , S.<br />
Fleener 1 and N. Frampton 2 . 1 Technical Services, CRP,<br />
Denver, PA and 2 SAD, CRP, Denver, PA. Sponsor: K.<br />
Williams.<br />
#273 EFFECTS OF FEED RESTRICTION ON<br />
EMBRYO-FETAL DEVELOPMENT IN RATS AND<br />
RABBITS. T. N. Lawrence, L. Tripp, M. S. Gilman, G.<br />
D. Cappon, M. E. Hurtt and T. L. Fleeman. Pfizer<br />
Global Research and Development, Groton, CT.<br />
#274 MICROARRAY-BASED ANALYSIS OF<br />
NUTRITION-ETHANOL INTERACTIONS<br />
DURING GESTATION. K. Shankar 1,3 , M.<br />
Hidestrand 1,3 , B. Yarberry 3 , R. Xiao 2,3 , F. A. Simmen 2,3 ,<br />
T. M. Badger 2,3,1 and M. J. Ronis 1,3 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Arkansas for Medical<br />
Sciences, Little Rock, AR, 2 Physiology and Biophysics,<br />
University <strong>of</strong> Arkansas for Medical Sciences, Little<br />
Rock, AR and 3 Arkansas Children’s Nutrition Center,<br />
Little Rock, AR.<br />
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<strong>Program</strong> Description<br />
#275 DEVELOPMENTAL AND REPRODUCTIVE<br />
TOXICITY OF DI-ISOHEPTYL PHTHALATE IN<br />
RODENTS. R. H. McKee 1 , K. L. Pavkov 1 , G. W.<br />
Trimmer 1 , L. H. Keller 2 and D. G. Stump 3 . 1 <strong>Toxicology</strong><br />
& Environmental Sciences, ExxonMobil Biomedical<br />
Sciences, Inc., Annandale, NJ, 2 ExxonMobil Chemical<br />
Company, Houston, TX and 3 Wil Research<br />
Laboratories, Ashland, OH.<br />
#276 ASSESSING THE ROLE OF CYTOSOLIC<br />
PHOSPHOLIPASE A (CPLA 2 ) INHIBITION IN<br />
PHTHALATE ESTER TOXICITY. R. A. Clewell, S.<br />
M. Ross, K. W. Gaido and M. E. Andersen. CIIT<br />
Centers for Health Research, Research Triangle Park,<br />
NC.<br />
#277 MEDIUM CHAIN CHLORINATED<br />
PARAFFIN(MCCP)-INDUCED HAEMORRHAGIC<br />
LESIONS IN NEONATAL SPRAGUE-DAWLEY<br />
RATS. A ROLE FOR ALTERED VITAMIN K<br />
DISPOSITION? C. Elcombe 1 , B. Elcombe 1 , R.<br />
Powrie 1 , S. Barton 3 and D. Farrar 2 . 1 CXR Biosciences<br />
Ltd., Dundee, United Kingdom, 2 Ineos Chlor Ltd.,<br />
Runcorn, United Kingdom and 3 Inveresk Research,<br />
Tranent, United Kingdom.<br />
#278 EFFECTS OF EXPOSURE TO 1-<br />
BROMOPROPANE IN GESTATION AND<br />
LACTATION PERIOD ON DAMS AND<br />
OFFSPRING IN RATS. K. Furuhashi 1 , H. Wang 1 , J.<br />
Kitoh 1 , H. Tsukamura 2 , K. Maeda 2 , Y. Takeuchi 1 and G.<br />
Ichihara 1 . 1 Nagoya University Graduate School <strong>of</strong><br />
Medicine, Nagoya, Japan and 2 Nagoya University<br />
Graduate School <strong>of</strong> Bioagricultural Sciences, Nagoya,<br />
Japan.<br />
#279 L-THREO 3, 4-DIHYDROXYPHENYLSERINE<br />
(DOPS) TREATMENT DURING PERINATAL<br />
DEVELOPMENT DOES NOT ALTER THE<br />
IMPACT OF DIETARY COPPER DEFICIENCY IN<br />
MICE. J. Pyatskowit and J. R. Prohaska. University <strong>of</strong><br />
Minnesota-Duluth, Duluth, MN. Sponsor: K. Wallace.<br />
#280 EFFECTS OF PERFLUOROOCTANOIC ACID<br />
EXPOSURE DURING PREGNANCY IN THE<br />
MOUSE. J. Thibodeaux, R. G. Hanson, J. M. Rogers<br />
and C. Lau. RTD, NHEERL, ORD, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#281 DEVELOPMENTAL TOXICITY OF 1-BUTANOL<br />
GIVEN TO RATS IN DRINKING WATER<br />
THROUGHOUT PREGNANCY. M. EMA 1 , H. Hara 2 ,<br />
M. Matsumoto 1 , A. Hirose 1 and E. KAMATA 1 . 1 Risk<br />
Assessment, National Institute <strong>of</strong> Health Sciences,<br />
Tokyo, Japan and 2 Ina Research, Inc., Ina, Japan.<br />
#282 ASSESSMENT OF ISOBUTYL HEPTYL KETONE<br />
(IBHK) BY ORAL GAVAGE IN AN OECD 422 RAT<br />
REPRODUCTION/DEVELOPMENTAL<br />
SCREENING STUDY WITH SYSTEMIC AND<br />
NEUROLOGICAL ENDPOINTS. D. M. Wilson, E.<br />
W. Carney, C. L. Zablotny, B. L. Yano and T. J. Cawley.<br />
Dow Chemical, Midland, MI.<br />
#283 A REVIEW OF THE ROLE OF GENOTOXICITY<br />
IN THE DEVELOPMENTAL/REPRODUCTIVE<br />
TOXICITY OF AGROCHEMICALS. P. R. IYER 1<br />
and D. W. Gammon 2 . 1 OEHHA/RCHAS,<br />
CALIFORNIA EPA, SACRAMENTO, CA and 2 CDPR,<br />
California EPA, Sacramento, CA.<br />
#284 DETERMINATION OF DART REFERENCE<br />
DOSES FOR WORKPLACE CHEMICAL<br />
EXPOSURES. C. J. Fields 1 , R. J. Parod 2 , T. A.<br />
Lewandowski 1 , C. A. Bradlee 2 , S. L. Jasti 2 and E. J.<br />
Kerfoot 2 . 1 Gradient Corporation, Seattle, WA and<br />
2 BASF Corporation, Wynadotte, MI.<br />
#285 DEVELOPMENT OF QSAR MODELS TO<br />
PREDICT DEVELOPMENTAL AND<br />
REPRODUCTIVE TOXICITY OF CHEMICALS.<br />
H. Choudhury 1 , R. Venkatapathy 2 and C. Moudgal 1 .<br />
1 NCEA, U.S. EPA, Sodertalje, Sweden and<br />
2 ORISE/NCEA-U.S. EPA, Cincinnati, OH.<br />
Abstract 286 is located on page 70.<br />
Monday Afternoon, March 7<br />
12:15 PM to 1:15 PM<br />
Ballroom B<br />
Monday Afternoon<br />
MEDICAL RESEARCH COUNCIL (MRC) LECTURE: NOVEL<br />
UNCOMPETITIVE ANTAGONISTS PROTECT NEURONS FROM<br />
EXCITOTOXIC, OXIDATIVE, AND NITROSATIVE STRESS<br />
Lecturer: Stuart A. Lipton, MD, PhD, Pr<strong>of</strong>essor, Burnham/Salk/Scripps<br />
Research Institutes and UC San Diego.<br />
Monday Afternoon, March 7<br />
12:15 PM to 1:15 PM<br />
Room RO1<br />
ROUNDTABLE SESSION: ELECTROCARDIOGRAPHY SAFETY<br />
EVALUATION STUDIES–NEW TECHNIQUES AND APPROACHES<br />
Chairperson(s): Lewis B. Kinter, AstraZeneca Pharmaceuticals, Wilmington,<br />
DE and Dennis J. Murphy, GlaxoSmithKline Pharmaceuticals, King <strong>of</strong><br />
Prussia, PA.<br />
#339 12:15 ELECTROCARDIOGRAPHY SAFETY<br />
EVALUATION STUDIES: NEW TECHNIQUES<br />
AND APPROACHES. L. B. Kinter 1 and D. J.<br />
Murphy 2 . 1 Safety Assessment, AstraZeneca,<br />
Wilmington, DE and 2 Drug Safety Assessment,<br />
GlaxoSmithKline, King <strong>of</strong> Prussia, PA.<br />
#340 12:20 CARDIAC ELECTROPHYSIOLOGY FROM THE<br />
SINGLE CELL TO THE INTACT HEART. R.<br />
Hamlin. Veterinary Cardiology, Ohio State University,<br />
Columbus, OH. Sponsor: L. Kinter.<br />
#341 12:30 TECHNIQUES AND ELECTROGRAPHIC LEAD<br />
PLACEMENTS FOR IMPLANTED ECG<br />
MONITORS. R. Coatney. Animal Modeling &<br />
Imaging, GlaxoSmithKline, King <strong>of</strong> Prussia, PA.<br />
Sponsor: L. Kinter.<br />
MONDAY<br />
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44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
MONDAY<br />
#342 12:45 INTRACARDIAC AND INTRAVASCULAR LEAD<br />
UTILIZATION: METHODS FOR IMPROVED<br />
DATA COLLECTION. C. Hassler. Safety<br />
Pharmacology, Battelle Memorial Laboratories,<br />
Columbus, OH. Sponsor: L. Kinter.<br />
#343 1:00 OBTAINING QUALITY ECG ENDPOINTS IN<br />
SAFETY PHARMACOLOGY AND GENERAL<br />
TOXICOLOGY STUDIES. ARE RESTRAINT AND<br />
SURGICAL INTERVENTION NECESSARY? M.<br />
Zawada and L. B. Kinter. Safety Assessment,<br />
AstraZeneca, Wilmington, DE.<br />
Abstract 344 is located on page74.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room RO8<br />
INNOVATIONS IN TOXICOLOGICAL SCIENCES SESSION:<br />
ALTERNATIVE RNA SPLICING: A MECHANISM FOR ENHANCING<br />
DIVERSITY OF GENE EXPRESSION<br />
Chairperson(s): Curt Omiecinski, Pennsylvania State University, University<br />
Park, PA and Craig Marcus, University <strong>of</strong> New Mexico, Albuquerque, NM.<br />
Endorsed by:<br />
Carcinogenesis SS<br />
Alternative RNA splicing is an emerging field <strong>of</strong> molecular science that has<br />
significant impact on the toxicological considerations <strong>of</strong> gene expression and<br />
protein function. The diversity <strong>of</strong> alternatively spliced transcripts has farreaching<br />
significance in terms <strong>of</strong> understanding interindividual differences in<br />
response to xenobiotics, mechanisms <strong>of</strong> toxicity at the molecular level, tissuespecific<br />
toxicity, and the mechanisms for regulating responses to environmental<br />
and chemical challenge. This Symposium will provide an overview <strong>of</strong> basic<br />
mechanisms and toxicological significance <strong>of</strong> RNA alternative splicing, with a<br />
focus on alternatively spliced xenobiotic nuclear receptors. Importantly, the<br />
session will also address bioinformatics-related issues pertaining to the identification<br />
<strong>of</strong> splice variants, including the design <strong>of</strong> microarray and genomics<br />
platforms that facilitate variant transcript detection.<br />
#286 1:30 INTRODUCTION TO SYMPOSIUM:<br />
ALTERNATIVE RNA SPLICING: A<br />
MECHANISM FOR ENHANCING DIVERSITY OF<br />
GENE EXPRESSION. C. Omiecinski. Ctr Molec<br />
<strong>Toxicology</strong>, Penn State University, University Park, PA.<br />
#287 1:35 DISCOVERY AND TISSUE-SPECIFIC<br />
MONITORING OF ALTERNATIVE PRE-MNRA<br />
SPLICING WVENTS USING INK-JET<br />
MICROARRAYS. J. M. Johnson, J. Castle, P. Garrett-<br />
Engele, Z. Kan, L. Lim, C. Armour, C. Raymond and E.<br />
Schadt. Informatics, Rosetta Inpharmatics, Merck &<br />
Co., Inc., Seattle, WA. Sponsor: C. Marcus.<br />
#288 2:10 FUNCTIONALLY DISTINCT ISOFORMS OF THE<br />
FARNESOID X RECEPTOR (FXR). P. A. Edwards,<br />
Y. Zhang and F. Y. Lee. Biological Chemistry, UCLA,<br />
Los Angeles, CA. Sponsor: C. Marcus.<br />
#289 2:45 HUMAN PXR: GENERATION OF DIVERSITY<br />
THROUGH ALTERNATIVE SPLICING AND<br />
POLYMORPHISM. E. G. Schuetz. Pharmaceutical<br />
Sciences, St. Jude Children’s Research Hospital,<br />
Memphis, TN. Sponsor: C. Marcus.<br />
#290 3:20 FUNCTIONALLY DISTINCT ALTERNATIVE<br />
SPLICE VARIANTS OF THE HUMAN<br />
XENOBIOTIC RECEPTOR, CAR. C. Omiecinski, S.<br />
Auerbach and M. Stoner. Ctr Molec <strong>Toxicology</strong>, Penn<br />
State University, University Park, PA.<br />
#291 3:55 STEROID RECEPTOR COACTIVATORS<br />
PROMOTE COORDINATE TRANCRIPTION AND<br />
ALTERNATIVE SPLICING. B. W. O’Malley.<br />
Molecular & Cellular Biology, Baylor College <strong>of</strong><br />
Medicine, Houston, TX. Sponsor: C. Marcus.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room 208<br />
SYMPOSIUM SESSION: DIETARY ACRYLAMIDE: NEW OR<br />
ANCIENT RISK?<br />
Chairperson(s): Philip M. Bolger, U.S. FDA, College Park, MD and Danial<br />
Doerge, National Center for Toxicological Research, Jefferson, AR.<br />
Endorsed by:<br />
Food Safety SS*<br />
Occupational and Public Health SS<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Initial investigations by Swedish researchers <strong>of</strong> fried and oven-baked foods indicated<br />
that acrylamide formation is associated with high temperature cooking<br />
processes for certain carbohydrate-rich foods, such as potatoes and cereals.<br />
Since then similar findings have been reported by researchers in other countries.<br />
The discovery <strong>of</strong> acrylamide in food is a concern because acrylamide is a potential<br />
carcinogen and genotoxicant, and a known human neurotoxicant. It does not<br />
appear to be present in uncooked food and is present in low or undetectable<br />
levels in foods cooked at lower temperatures, such as by boiling. One plausible<br />
mechanism responsible for acrylamide formation in carbohydrate-rich foods<br />
cooked at high temperatures is the Mallard reaction between asparagine and<br />
certain sugars. However, not enough is known about acrylamide formation to<br />
identify safe, effective, and practical modifications to food processing techniques<br />
that will clearly prevent or reduce formation. Identifying major<br />
mechanisms <strong>of</strong> formation is an important step in identifying ways to reduce or<br />
prevent acrylamide formation during cooking. There are significant uncertainties<br />
about the impact <strong>of</strong> dietary acrylamide exposure on public health, since<br />
foods reported to contain acrylamide have been consumed for many years.<br />
While acrylamide causes cancer in laboratory animals at high doses, it is not<br />
clear whether a similar response would occur at the much lower levels found in<br />
food. Several epidemiological environmental studies <strong>of</strong> workplace and dietary<br />
exposures have failed to show an increased cancer risk with acrylamide exposure.<br />
It is also conceivable that subtle effects can occur on the developing<br />
nervous system at acrylamide doses lower than those that have been studied in<br />
animals and humans. To better assess the risk <strong>of</strong> acrylamide information is<br />
needed on dietary exposure, bioavailability from food, biomarkers <strong>of</strong> exposure,<br />
and the potential to cause cancer and neurotoxic or neurodevelopmental effects<br />
when consumed in food.<br />
#292 1:30 OVERVIEW OF DIETARY ACRYLAMIDE. P. M.<br />
Bolger. Center for Food Safety and Applied Nutrition,<br />
US Food and Drug Administration, College Park, MD.<br />
#293 1:35 TOXICOKINETICS OF ACRYLAMIDE AND<br />
GLYCIDAMIDE IN B6C3F1 MICE AND FISCHER<br />
344 RATS. D. R. Doerge 1 , J. F. Young 2 , L. McDaniel 1 ,<br />
N. C. Twaddle 1 and M. I. Churchwell 1 . 1 Biochem.<br />
Toxicol., NCTR, Jefferson, AR and 2 Biometry and Risk<br />
Assessment, NCTR, Jefferson, AR. Sponsor: P. Bolger.<br />
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<strong>Program</strong> Description<br />
#294 1:50 REFERENCE VALUES IN THE ACRYLAMIDE<br />
IRIS ASSESSMENT DEVELOPED BY THE U.S.<br />
EPA. R. S. DeWoskin. ORD/NCEA, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#295 2:30 DIETARY ACRYLAMIDE AND RISK OF HUMAN<br />
CANCER: THE ROLE OF EPIDEMIOLOGY. L.<br />
Mucci 1 and H. Adami 2 . 1 Channing Laboratory, Harvard<br />
Medical School, Boston, MA and 2 Department <strong>of</strong><br />
Medical Epidemiology and Biostatistics, Karolinska<br />
Institutet, Stockholm, Sweden. Sponsor: P. Bolger.<br />
#296 3:10 AN INTERNATIONAL SAFETY/RISK<br />
ASSESSMENT OF ACRYLAMIDE. S. H. Henry.<br />
Center for Food Safety & Applied Nutrition (HFS-308),<br />
U. S. Food & Drug Admin., College Park, MD.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
La Louisiane Ballroom B<br />
SYMPOSIUM SESSION: ENVIRONMENTAL FACTORS AFFECTING<br />
BREAST CANCER SUSCEPTIBILITY<br />
Chairperson(s): Suzanne Fenton, U.S. EPA, Research Triangle Park, NC and<br />
Scott W. Burchiel, University <strong>of</strong> New Mexico, Albuquerque, NM.<br />
Endorsed by:<br />
Carcinogenesis SS<br />
Reproductive and Development SS*<br />
Toxicologic and Exploratory Pathology SS<br />
Women in <strong>Toxicology</strong> SS<br />
Breast cancer is still the most common malignancy afflicting women in the<br />
Western world. Although substantial progress has been made in elucidating<br />
some <strong>of</strong> the genetic contributors to breast cancer (i.e., the highly penetrant<br />
susceptibility genes, BRCA1 and 2), it has been estimated that only 6-12% <strong>of</strong><br />
all breast cancer cases are due to heritable factors. Few other specific factors<br />
have been identified that contribute significantly to an individuals lifetime risk<br />
<strong>of</strong> breast cancer. It has become apparent that elements affecting cancer susceptibility<br />
(genetic or environmental components) cannot be considered separately.<br />
Environmental factors (e.g., industrial compounds, pharmaceuticals, diet, occupational<br />
hazards) have been identified in both epidemiological and rodent<br />
studies that alter breast development and tumor formation. These constituents<br />
may act as either a mutagen or as a developmental compound able to alter<br />
susceptibility to carcinogens. In addition to the contributions <strong>of</strong> environmental<br />
factors, a large percentage <strong>of</strong> cancer cases are due to sporadic mutations that<br />
may occur as a result <strong>of</strong> spontaneous genetic events, and the interactions<br />
between gene and environmental factors. A relatively recent focus in the breast<br />
cancer field is on the interaction between genes and environment as the causal<br />
mechanism in the disease. Primary candidates for gene-environment interaction<br />
studies have been genes that encode enzymes involved in the metabolism <strong>of</strong><br />
established cancer risk factors and those involving oxidative stress response.<br />
There are common varying forms <strong>of</strong> these genes (polymorphisms) that may<br />
directly result in impacting the risk <strong>of</strong> cancer by altering normal metabolism,<br />
circulating hormone levels, ability to respond correctly to normal stressors, or<br />
response to environmental factors. We will present data from both epidemiological<br />
and rodent studies demonstrating the importance that environmental factors<br />
play in breast cancer susceptibility. These studies will elucidate the importance<br />
<strong>of</strong> evaluating gene-environment interactions and the various environmental<br />
factors, such as diet and endocrine disrupting chemicals, on breast cancer risk<br />
assessment.<br />
#297 1:30 ENVIRONMENTAL FACTORS AFFECTING<br />
BREAST CANCER SUSCEPTIBILITY. S. Fenton.<br />
U.S. EPA, Research Triangle Park, NC.<br />
#298 1:45 GENE-ENVIRONMENT INTERACTIONS IN THE<br />
ETIOLOGY OF BREAST CANCER. C. Ambrosone.<br />
Roswell Park Cancer Institute, Buffalo, NY. Sponsor: S.<br />
Fenton.<br />
#299 2:15 INFLUENCE OF ENDOCRINE DISRUPTING<br />
COMPOUNDS (EDCS) ON MAMMARY GLAND<br />
DEVELOPMENT AND TUMOR<br />
SUSCEPTIBILITY. S. Fenton 1 and J. L. Rayner 2 .<br />
1 Reproductive <strong>Toxicology</strong> Division, U.S. EPA,<br />
Research Triangle Park, NC and 2 DESE, UNC, Chapel<br />
Hill, NC.<br />
#300 2:45 EARLY LIFE DIETARY ESTROGENIC<br />
EXPOSURES AND LATER SUSCEPTIBILITY TO<br />
MAMMARY TUMORIGENESIS. L. A. Hilakivi-<br />
Clarke, B. Yu and M. Martin. Oncology, Georgetown<br />
University, Washington, DC. Sponsor: S. Fenton.<br />
#301 3:15 DNA DAMAGE/REPAIR IN HUMAN BREAST<br />
CANCER RISK. J. J. Hu. Cancer Biology, Wake<br />
Forest U. School <strong>of</strong> Medicine, Winston-Salem, NC.<br />
#302 3:45 ROLE OF OXIDANT STRESS IN THE<br />
ACTIVATION OF GROWTH FACTOR<br />
SIGNALING PATHWAYS IN HUMAN BREAST<br />
EPITHELIAL CELLS BY ENVIRONMENTAL<br />
POLYCYCLIC AROMATIC HYDROCARBONS<br />
(PAHS). S. W. Burchiel 1 , A. D. Burdick 2 , K. F.<br />
Melendez 1 , F. T. Lauer 1 and J. W. Davis 3 . 1 College <strong>of</strong><br />
Pharmacy, University <strong>of</strong> New Mexico, Albuquerque,<br />
NM, 2 Center for Molecular <strong>Toxicology</strong>, Penn State<br />
University, University Park, PA and 3 Worldwide Safety<br />
Sciences, Pfizer Global Research and Development, St.<br />
Louis, MO.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 71
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room RO4<br />
SYMPOSIUM SESSION: THE MULTI-SITE AMBIENT PARTICLE<br />
STUDY (MAPS): AN INTEGRATED APPROACH TO STUDYING<br />
HEALTH EFFECTS OF PM COMPONENTS<br />
Chairperson(s): Robert Devlin, National Health and Environmental Effects<br />
Research Laboratory, Research Triangle Park, NC and Terry Gordon, New<br />
York University, Tuxedo, NY.<br />
Endorsed by:<br />
Inhalation SS*<br />
Occupational and Public Health SS<br />
The World Health Organization estimates that particulate air pollution (PM) is<br />
responsible for more than 500, 000 deaths worldwide each year. A large number<br />
<strong>of</strong> epidemiology studies have associated PM mass with increased mortality, and<br />
the EPA currently regulates PM on the basis <strong>of</strong> mass in different size ranges.<br />
However, recent studies suggest that PM derived from different sources may<br />
differ in toxicity and that specific PM components may serve as markers for<br />
different sources, suggesting an alternative, more efficient way <strong>of</strong> regulating<br />
PM. The overall objective <strong>of</strong> MAPS was to collect particles from several<br />
different geographical regions, characterize their physical and chemical properties,<br />
and make them available to investigators for in vitro and animal instillation<br />
health studies that can relate health effects with PM components and ultimately<br />
sources. Airborne particles in the ultrafine, fine, and coarse size ranges were<br />
collected in eight different locations in the US and Europe. The sites were<br />
selected to take advantage <strong>of</strong> regional differences in PM sources and components.<br />
Weekly samples were collected for a period <strong>of</strong> a month in each location,<br />
using a 3 stage particle impactor (developed at Harvard University) which is<br />
capable <strong>of</strong> collecting several mg <strong>of</strong> material during a weekly sampling interval.<br />
The particles were then assayed for a number <strong>of</strong> chemical components and made<br />
available to investigators in several different laboratories. This symposium will<br />
describe some <strong>of</strong> the studies which have characterized health effects associated<br />
with PM and PM components from each <strong>of</strong> the different geographical locations.<br />
Relating adverse health effects to specific PM size modes and specific PM<br />
chemical components is the first step towards relating these effects to PM<br />
derived from specific sources. This will ultimately allow the EPA to more effectively<br />
implement PM standards, thereby reducing not only the health impacts<br />
now associated with PM, but also their substantial impacts on quality <strong>of</strong> life and<br />
the national economy.<br />
#303 1:30 THE MULTI-SITE AMBIENT PARTICLE STUDY<br />
(MAPS): AN INTEGRATED APPROACH TO<br />
STUDYING HEALTH EFFECTS OF PM<br />
COMPONENTS. R. Devlin 1 and T. Gordon 2 . 1 U.S.<br />
EPA, Research Triangle Park, NC and 2 Environmental<br />
Medicine, New York University, Tuxedo, NY.<br />
#304 1:45 SAMPLE CHARACTERIZATION AND SOURCE<br />
APPORTIONMENT OF AMBIENT<br />
PARTICULATE MATTER: COMBINING<br />
ATMOSPHERIC SCIENCE AND LUNG<br />
TOXICOLOGY. J. M. Veranth 1 , G. S. Yost 1 , J. C.<br />
Chow 2 and J. G. Watson 2 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Utah, Salt Lake City, UT and<br />
2 Atmospheric Sciences, Desert Research Institute, Reno,<br />
NV.<br />
#305 2:15 EFFECTS OF AMBIENT PM ON OXIDATIVE<br />
STRESS AND SIGNALING PATHWAYS. L. Chen 1 ,<br />
X. Jin 1 , C. Huang 1 , T. Gordon 1 and J. Hwang 2 .<br />
1 Environmental Medicine, NYU School <strong>of</strong> Medicine,<br />
Tuxedo, NY and 2 Statistics Institute, Academia Sinica,<br />
Taipei, Taiwan.<br />
#306 2:45 EFFECTS ON CYTOKINE PRODUCTION BY<br />
MACROPHAGES, ENDOTHELIUM AND<br />
EPITHELIAL CELLS. J. N. Finkelstein 1,2 .<br />
1 Pediatrics, University <strong>of</strong> Rochester, Rochester, NY and<br />
2 Evironmental Medicine, University <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#307 3:15 HEALTH EFFECTS OF PARTICLES FROM<br />
TRAFFIC-RELATED AMBIENT AIR<br />
POLLUTION ON RESPIRATORY ALLERGY AND<br />
INFLAMMATION: A EUROPEAN MULTISITE<br />
STUDY. F. Cassee 1,3 , T. Sandstrom 3 and E. Dybing 2 .<br />
1 Centre for Environmental Health Research (MGO),<br />
National Institute for Public Health and the<br />
Environment (RIVM), Bilthoven, Netherlands,<br />
2 Norwegian Institute <strong>of</strong> Public Health, Oslo, Norway<br />
and 3 Medicine and Allergy University Hospital, Umea,<br />
Sweden.<br />
#308 3:45 EFFECT OF SIZE FRACTIONATED AMBIENT<br />
PM SAMPLES ON INDUCTION OF<br />
PULMONARY ALLERGY IN MICE. M. Gilmour.<br />
NHEERL, U.S. EPA, Research Triangle Park, NC.<br />
Abstract 309 is located on page 94.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room 220<br />
WORKSHOP SESSION: ENVIRONMENTAL TERRORISM:<br />
DEVELOPMENT OF EVACUATION, RE-ENTRY AND RE-USE<br />
GUIDELINES FOR CHEMICAL, BIOLOGICAL AND<br />
RADIOLOGICAL AGENTS<br />
Chairperson(s): Mark Maddaloni, U.S. EPA, New York, NY and Annie<br />
Jarabek, U.S. EPA, Research Triangle Park, NC.<br />
Endorsed by:<br />
Risk Assessment SS*<br />
The collapse <strong>of</strong> the World Trade Center (WTC) presented a host <strong>of</strong> challenges<br />
to the governmental agencies charged with making decisions on evacuation, reentry<br />
and long-term re-habitation for the impacted public in Lower Manhattan.<br />
Occupational standards, ranging from immediately dangerous to life and health<br />
(IDLH) concentrations to long-term permissible exposure limits (PELs) existed<br />
for many <strong>of</strong> the building components and combustion by-products released from<br />
the WTC disaster. However, these standards are generally not well-suited for<br />
application to the general public (i.e. residents and <strong>of</strong>fice workers).<br />
Conventional environmental standards and guidelines have focused on establishing<br />
long-term exposure limits for chemical contaminants in the ambient<br />
environment. That leaves a lot <strong>of</strong> poorly chartered territory for assessing environmental<br />
terrorism incidents that may involve biological or radiological agents<br />
within indoor settings, as well as in the ambient environment. The anthrax<br />
bioterrorism event <strong>of</strong> October, 2001 made that abundantly clear. The environmental<br />
response to the WTC disaster involved numerous governmental agencies<br />
along with the inevitable overlapping <strong>of</strong> jurisdictions and responsibilities. A<br />
future environmental terrorism event will likely follow suit. Accordingly, this<br />
workshop will engage the key governmental agencies involved in protecting the<br />
public health from environmental terrorism. The workshop will focus on<br />
comparing and contrasting available methods for deriving short term (i.e. evacuation),<br />
subchronic (i.e. re-entry) and long-term (i.e. re-habitation) exposure<br />
criteria a for chemical, biological and radiological agents. Of particular interest<br />
will be the role <strong>of</strong> background levels, analytical detection limits, social and<br />
economic disruption, and other miscellaneous factors in the setting <strong>of</strong> exposure<br />
limits. Risk levels for the different exposure scenarios and agent classes will be<br />
evaluated for comparability. Data gaps and methodological shortcomings will<br />
be identified for representative exposure scenarios within each class <strong>of</strong> agents.<br />
72<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#327 1:30 ENVIRONMENTAL TERRORISM:<br />
DEVELOPMENT OF EVACUATION, RE-ENTRY<br />
AND RE-USE GUIDELINES FOR CHEMICAL,<br />
BIOLOGICAL AND RADIOLOGICAL AGENTS.<br />
M. A. Maddaloni. U.S. EPA, New York. Sponsor: A.<br />
Jarabek.<br />
#328 1:45 AN EPA PERSPECTIVE ON CHEMICAL<br />
CONTAMINATION CLEAN-UP. S. Sterling, I. P.<br />
Baumel and C. Sonich-Mullin. ORD/NHSRC, U.S.<br />
EPA, Washington, DC. Sponsor: M. Maddaloni.<br />
#329 2:15 A MILITARY APPROACH TO ASSESSING<br />
HEALTH RISK. V. Hauschild and B. Thran.<br />
Directorate <strong>of</strong> Health Risk Management, US Army Ctr<br />
for Health Promotion and Preventive Medicine,<br />
Aberdeen Proving Ground, Edgewood Area, MD.<br />
Sponsor: M. Maddaloni.<br />
#330 2:45 BIOTERRORIST THREATS TO THE US FOOD<br />
SUPPLY SYSTEM: A RISK ASSESSMENT<br />
PERSPECTIVE. B. Hope. Air Quality Division,<br />
Oregon Department <strong>of</strong> Environmental Quality, Portland,<br />
OR. Sponsor: A. Jarabeck.<br />
#331 3:15 A PRIMER ON RADIATION ISSUES RELATED<br />
TO NUCLEAR TERRORISM. S. L. Simon.<br />
Radiation Epidemiology Branch, National Cancer<br />
Institutes, Bethesda, MD. Sponsor: M. Maddaloni.<br />
#332 3:45 DEVELOPMENT OF OPERATIONAL<br />
GUIDELINES FOR CONSEQUENCE<br />
MANAGEMENT OF RADIOLOGICAL<br />
DISPERSAL DEVICE INCIDENTS. S. Domotor 1 , A.<br />
Wallo 1 , C. YU 2 , D. LePoire 2 and S. Kamboj 2 . 1 US<br />
DOE, Washington, DC and 2 Argonne National<br />
Laboratory, Washington, DC. Sponsor: A. Jarabek.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room RO6<br />
WORKSHOP SESSION: HIGH THROUGHPUT SCREENING<br />
APPROACHES IN GENETIC TOXICOLOGY<br />
Chairperson(s): Jiri Aubrecht, Pfizer, Inc., Groton, CT and Robert Schiestl,<br />
University <strong>of</strong> California, Los Angeles, Los Angeles, CA.<br />
Endorsed by:<br />
In Vitro SS*<br />
Risk Assessment SS<br />
Recent progress in combinatorial chemistry, molecular biology, genomics, and<br />
automation has enabled identifying a relatively large number <strong>of</strong> compounds<br />
capable <strong>of</strong> reacting with intended pharmacological targets. However, 40% <strong>of</strong><br />
drug candidates ultimately fail during clinical development due to safety related<br />
issues. The overall attrition <strong>of</strong> drug candidates due to genetic toxicology issues<br />
alone includes about 12% <strong>of</strong> drug candidates. This causes delays in the introduction<br />
<strong>of</strong> vital drugs to patients and significant economic losses. Therefore, the<br />
development <strong>of</strong> relevant mechanism-based high throughput screening technologies<br />
to assess genetic toxicity at the early stages <strong>of</strong> drug discovery with<br />
relatively limited amount <strong>of</strong> chemical is extremely important. Genetic toxicology<br />
provides the necessary information for assessment <strong>of</strong> the genotoxic risk<br />
associated with the use <strong>of</strong> drugs. Since the beginning <strong>of</strong> genotoxicity testing in<br />
the early 1970s, many different test systems have been developed and used.<br />
Since no single test is capable <strong>of</strong> detecting all genotoxic agents, the current standard<br />
in vitro genotoxicity testing consists <strong>of</strong> evaluating mutagenicity (bacterial<br />
reverse mutation assay) and chromosome damage (lymphocyte aberration assay<br />
or mouse lymphoma assay). Unfortunately, these standard in vitro assays are not<br />
amenable to high throughput testing and their application in early phases <strong>of</strong> drug<br />
discovery is not feasible. Therefore, the research and assay development efforts<br />
have been directed to developing alternative approaches, technologies and/or<br />
endpoints. The speakers in this session present emerging state-<strong>of</strong>-the-art technologies<br />
under development and/or currently used in the pharmaceutical<br />
industry. The topics covered in this symposium comprise high throughput<br />
versions <strong>of</strong> the Salmonella assay, assays for DNA deletions, chromosome aberrations,<br />
the comet assay and a gene expression reporter assay. The presentations<br />
will cover exciting developments that may spark further interest in the automation<br />
<strong>of</strong> genotoxicity assays.<br />
#333 1:30 HIGH THROUGHPUT SCREENING<br />
APPROACHES IN GENETIC TOXICOLOGY. R.<br />
H. Schiestl 2 and J. Aubrecht 1 . 1 Safety Sciences, Pfizer,<br />
Inc., Groton, CT and 2 Departments <strong>of</strong> Pathology and<br />
Environmental Health, UCLA, Los Angeles, CA.<br />
#334 1:40 BIOLUMINESCENT SALMONELLA REVERSE<br />
MUTATION ASSAY: A HIGH THROUGHPUT<br />
APPROACH FOR DETECTION OF<br />
MUTAGENICITY. J. Aubrecht. Safety Sciences,<br />
Pfizer, Inc., Groton, CT.<br />
#335 2:10 BIOLUMINESCENT YEAST DEL ASSAY TO<br />
DETECT CARCINOGENS AND CLASTOGENS. R.<br />
Schiestl 1 and J. Aubrecht 2 . 1 Pathology, UCLA, Los<br />
Angeles, CA and 2 Safety Sciences, Pfizer, Inc., Groton,<br />
CT.<br />
#336 2:40 APPLICATION OF A HIGH THROUGHPUT<br />
COMET ASSAY IN DRUG DISCOVERY. A.<br />
Hartmann 1 and W. Frieauff 2 . 1 Non Clinical Safety,<br />
F.H<strong>of</strong>fmann-La Roche Ltd., Basel, Switzerland and<br />
2 GenSafe / Precinical Safety, Novartis Pharmacology,<br />
Basel, Switzerland. Sponsor: J. Aubrecht.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 73
44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
MONDAY<br />
#337 3:10 A FLOW CYTOMETRIC PROCESS FOR<br />
DETECTING ANEUGENIC AGENTS IN VITRO. P.<br />
A. Muehlbauer and M. J. Schuler. Genetic <strong>Toxicology</strong>,<br />
Pfizer Global R & D, Groton, CT.<br />
#338 3:40 HIGH-THROUGHPUT SCREENING USING<br />
STRESS-RESPONSIVE REPORTER GENE<br />
ASSAYS. R. Brennan 1 and J. D. Haley 2 . 1 <strong>Toxicology</strong>,<br />
Iconix Pharmaceuticals Inc., Mountain View, CA and<br />
2 Cancer Cell Biology, OSI Pharmaceuticals Inc.,<br />
Farmingdale, NY.<br />
Abstract 339 is located on page 69.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room RO1<br />
PLATFORM SESSION: COMPUTATIONAL TOXICOLOGY:<br />
ADVANCES AND APPLICATIONS<br />
Chairperson(s): Melvin Andersen, CIIT Centers for Health Research,<br />
Research Triangle Park, NC and Kannan Krishnan, Université de Montréal,<br />
Montreal, QC, Canada.<br />
#344 1:30 BIOLOGICALLY-BASED MATHEMATICAL<br />
MODEL FOR GENE EXPRESSION DUE TO JP-8<br />
EXPOSURE TO SKIN. J. N. McDougal 1 , C. M.<br />
Garrett 1 , C. A. Amato 1 , Y. Zheng 2 , Q. Zhang 3 and R. B.<br />
Conolly 3 . 1 Department <strong>of</strong> Pharmacology & <strong>Toxicology</strong>,<br />
Wright State University School <strong>of</strong> Medicine, Dayton,<br />
OH, 2 Department <strong>of</strong> Biomedical Engineering, Purdue<br />
University, West Lafayette, IN and 3 Center for<br />
Computational Systems Biology and Human Health<br />
Assessment, CIIT Centers for Health Research,<br />
Research Triangle Park, NC.<br />
#345 1:50 MODELLING THE RELATIONSHIP BETWEEN<br />
NICKEL AND CHROMIUM EXPOSURE AND<br />
CONTACT DERMATITIS. S. Franks and A. Jones.<br />
Health and Safety Laboratory, Buxton, United<br />
Kingdom. Sponsor: R. Conolly.<br />
#346 2:10 COMPUTATIONAL MODELS FOR THE<br />
ACQUISITION OF NEOCORTICAL NEURONS IN<br />
THE DEVELOPING HUMAN, MONKEY, AND<br />
MOUSE: CROSS SPECIES COMPARISON OF<br />
TOXICODYNAMICS. J. M. Gohlke, W. C. Griffith<br />
and E. M. Faustman. Environmental and Occupational<br />
Health Sciences, University <strong>of</strong> Washington, Seattle,<br />
WA.<br />
#347 2:30 MAGNETIC RESONANCE IMAGING AND<br />
COMPUTATIONAL FLUID DYNAMICS<br />
SIMULATIONS OF RABBIT NASAL AIRFLOWS<br />
FOR HYBRID CFD/PBPK MODELING OF<br />
METHYL IODIDE. H. E. Trease 1 , K. R. Minard 1 , L.<br />
L. Trease 1 , R. A. Corley 1 , J. S. Kimbell 2 , J. R.<br />
Harkema 3 , J. H. Kinzell 4 and M. L. Gargas 5 . 1 Battelle<br />
Northwest, Richland, WA, 2 CIIT Centers for Health<br />
Research, Research Triangle Park, NC, 3 Michigan State<br />
University, East Lansing, MI, 4 Arvesta Corp., San<br />
Francisco, CA and 5 The Sapphire Group, Beavercreek,<br />
OH.<br />
#348 2:50 IN SILICO PHARMACOGENETIC ANALYSIS OF<br />
R-WARFARIN METABOLISM. Y. Guo 1 , P. Cheung 2 ,<br />
J. Wang 1 , G. Liao 1 , J. Usuka 1 , M. Masjedizadeh 3 , P.<br />
Weller 2 and G. Peltz 1 . 1 Genetics & Genomics, Roche<br />
Palo Alto, Palo Alto, CA, 2 DMPK, Roche Palo Alto,<br />
Palo Alto, CA and 3 Chemical Services, Roche Palo<br />
Alto, Palo Alto, CA.<br />
#349 3:10 AN INTEGRATED QSAR-PBPK MODEL FOR<br />
SIMULATING PHARMACOKINETICS OF<br />
CHEMICALS IN MIXTURES. K. Price and K.<br />
Krishnan. Occupational and Environmental Health,<br />
Universite de Montreal, Montreal, QC, Canada.<br />
#350 3:30 ISSUES IN THE USE OF PBPK MODELING IN<br />
THE DEVELOPMENT OF CANCER SLOPE<br />
FACTORS FOR PERCHLOROETHYLENE. J. E.<br />
Kester, P. Gentry, T. R. Covington and H. J. Clewell.<br />
ENVIRON Health Sciences Institute, Ruston, LA.<br />
#351 3:50 NEW APPLICATIONS FOR THE LEAD PBPK<br />
MODEL. S. M. Hays. Summit <strong>Toxicology</strong>, Lyons, CO.<br />
Sponsor: D. Pyatt.<br />
#352 4:10 CAN HYDROGEN CYANIDE POISONING BE<br />
DETECTED IN EXHALED AIR? G. Johanson, K.<br />
Stamyr and P. Nord. Work Environment <strong>Toxicology</strong>,<br />
Karolinska Institute, Stockholm, Sweden.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Room RO3<br />
PLATFORM SESSION: BIOTRANSFORMATION/CYTOCHROME<br />
P450<br />
Chairperson(s): Ernest Hodgson, North Carolina State University, Raleigh,<br />
NC and Burhan Ghanayem, NIEHS, Research Triangle Park, NC.<br />
#353 1:30 LARGE-SCALE GENE EXPRESSION<br />
PROFILING IN RATS IDENTIFIES MANY<br />
NOVEL CYP1A1 INDUCERS AND AH<br />
RECEPTOR LIGANDS. W. Hu 1 , M. R. Fielden 1 , D.<br />
Baston 2 , B. Zhao 2 , Y. Song 2 , J. Bohonowych 2 , A.<br />
Soshilov 2 , D. DeGroot 2 , C. Sorrentino 2 , M. Denison 2<br />
and K. Kolaja 1 . 1 Chemogenomics and <strong>Toxicology</strong>,<br />
Iconix Pharmaceuticals Inc., Mountain View, CA and<br />
2 Department <strong>of</strong> Environmental <strong>Toxicology</strong>, University<br />
<strong>of</strong> California Davis, Davis, CA.<br />
#354 1:50 EFFECTS OF FLAVONOIDS ON CYP1<br />
EXPRESSION IN RL95-2 ENDOMETRIAL<br />
CANCER CELLS. Z. R. Master 1 , T. R. Sutter 2 and K.<br />
L. Willett 1 . 1 Pharmacology and Environmental<br />
<strong>Toxicology</strong> Research <strong>Program</strong>, University <strong>of</strong><br />
Mississippi, University, MS and 2 W. Harry Feinstone<br />
Center for Genomic Research, University <strong>of</strong> Memphis,<br />
Memphis, TN.<br />
#355 2:10 REDUCTION OF OBESITY IS ASSOCIATED<br />
WITH INCREASED HEPATIC CYP3A<br />
EXPRESSION IN WOMEN. D. Springer 1 , T. I.<br />
Leakey 1 , R. J. Feuers 1 , C. Buffington 2 , G. S. Cowan 2<br />
and J. E. Leakey 1 . 1 OSC, NCTR, Jefferson, AR and<br />
2 Department <strong>of</strong> Surgery, University <strong>of</strong> Tennessee,<br />
Memphys, TN.<br />
74<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#356<br />
#357<br />
#358<br />
#359<br />
#360<br />
#361<br />
Monday<br />
1:30 PM<br />
Room RO2<br />
PLATFORM<br />
Chairperson(s):<br />
Richmond,<br />
#362<br />
2:30<br />
2:50<br />
3:10<br />
3:30<br />
3:50<br />
4:10<br />
Afternoon,<br />
to 4:30<br />
SESSION:<br />
VA and<br />
1:30<br />
BIPHENYL PROPARGYL ETHERS AS<br />
#363 1:52 THE ROLE OF CYCLIN DEPENDENT KINASE<br />
INHIBITORS OF CYP 1A1, CYP 1A2, AND CYP<br />
INHIBITOR P21 IN TCDD-INDUCED THYMIC<br />
2B1. N. E. Hopkins 1 , B. Bowman 2 , T. Smith 2,1 , C.<br />
ATROPHY. M. Fisher 1 , M. Nagarkatti 2 and P. S.<br />
DeCuir-Charbonnet 1 , A. Henderson 1 and M.<br />
Nagarkatti 1,2 . 1 Pharmacology and <strong>Toxicology</strong>, Virginia<br />
Foroozesh 2 . 1 Cell & Molecular Biology, Tulane<br />
Commonwealth University School <strong>of</strong> Medicine,<br />
University, New Orleans, LA and 2 Chemistry, Xavier<br />
Richmond, VA and 2 Microbiology and Immunology,<br />
University, New Orleans, LA.<br />
Virginia Commonwealth University School <strong>of</strong><br />
Medicine, Richmond, VA.<br />
USE OF A HUMAN HEPATOCYTE-DERIVED<br />
CELL LINE TO SIMULTANEOUSLY ASSESS<br />
#364 2:14 TCDD SUPPRESSES ANTIGEN-SPECIFIC<br />
CYP3A4 INDUCTION AND TIME-DEPENDENT<br />
INTERACTIONS BETWEEN OTII CD4 T CELLS<br />
INHIBITION. S. L. Ripp 1 , K. A. Trevena 1 , D. R.<br />
AND OVA-LOADED DENDRITIC CELLS. S.<br />
Gibbons 2,1 and J. B. Mills 1 . 1 Pharmacokinetics,<br />
Navarro 1 and D. M. Shepherd 1,2 . 1 CEHS, University <strong>of</strong><br />
Dynamics, & Metabolism, Pfizer Global Research &<br />
Montana, Missoula, MT and 2 Biomedical &<br />
Development, Groton, CT and 2 Michigan State<br />
Pharmaceutical Sciences, University <strong>of</strong> Montana,<br />
University, East Lansing, MI.<br />
Missoula, MT.<br />
HUMAN NAPHTHALENE METABOLISM. T. M. #365 2:36 SUPERANTIGEN-PRIMED T CELLS EXPOSED<br />
Cho, R. L. Rose and E. Hodgson. Environmental &<br />
TO 2, 3, 7, 8-TETRACHLORODIBENZO-P-<br />
Molecular <strong>Toxicology</strong>, North Carolina State University,<br />
DIOXIN (TCDD) UNDERGO APOPTOSIS<br />
Raleigh, NC.<br />
DURING THE FIRST ENCOUNTER AND<br />
EXHIBIT ANERGY UPON RESTIMULATION<br />
ROLE OF PULMONARY CYTOCHROME P450<br />
WITH THE ANTIGEN. L. Faulconer 2 , I. Camacho 1 3A1 IN 1-NITRONAPHTHALENE<br />
M. Nagarkatti 1 and P. Nagarkatti 2 . 1 Microbiology and<br />
BIOACTIVATION AND INJURY IN ADULT AND<br />
Immunology, Virginia Commonwealth University,<br />
POSTNATAL RATS. K. C. Day, J. D. Reynolds, D. R.<br />
Richmond, VA and 2 Pharmacology and <strong>Toxicology</strong>,<br />
Morin, C. G. Plopper and M. V. Fanucchi. University <strong>of</strong><br />
Virginia Commonwealth University, Richmond, VA.<br />
California, Davis, Davis, CA.<br />
#366 2:58 B CELL MATURATION AND TCDD-INDUCED<br />
MODIFICATION OF PULMONARY CYP2B1 AND<br />
MODULATION OF THE 3’α ENHANCER. C. E.<br />
INDUCED CYP1A1 ACTIVITIES BY<br />
Sulentic. Pharmacology&<strong>Toxicology</strong>, Wright State<br />
INTRAVENOUS INJECTION OF IRON<br />
DEXTRAN. M. M. Ghanem 1,2 , L. Battelli 1 University, Dayton, OH.<br />
, M.<br />
Barger 1 , J. Nath 2 and A. F. Hubbs 1 . 1 HELD, NIOSH, #367 3:20 SYNTHETIC AND ENDOGENOUS PPARγ<br />
CDC, Morgantown, WV and 2 Genetics and<br />
AGONISTS, GW7845, 15-DEOXY-∆ 12, 14 -<br />
Developmental Biology <strong>Program</strong>, WVU, Morgantown,<br />
PROSTAGLANDIN J 2 , AND MONO-(2-<br />
WV. Sponsor: V. Castranova.<br />
ETHYLHEXYL) PHTHALATE, ACTIVATE<br />
COMPLEX CASPASE CASCADES IN PRO/PRE-B<br />
ROLE OF CYP2E1 IN THE OXIDATION OF<br />
CELLS. J. Schlezinger, J. Emberley and D. Sherr.<br />
ACRYLAMIDE (AA) TO GLYCIDAMIDE (GA)<br />
Environmental Health, Boston University School <strong>of</strong><br />
AND FORMATION OF DNA AND HEMOGLOBIN<br />
ADDUCTS. B. I. Ghanayem 1 , L. McDaniel 2 Public Health, Boston, MA.<br />
, M. I.<br />
Churchwell 2 , N. C. Twaddle 2 , R. Snyder 3 , T. R. Fennell 3 #368 3:42 CB2 CANNABINOID RECEPTOR AGONIST,<br />
and D. R. Doerge 2 . 1 Laboratory <strong>of</strong> Pharmacology and<br />
JWH015 TRIGGERS APOPTOSIS IN IMMUNE<br />
Chemistry, NIEHS/NIH, Research Triangle Park, NC,<br />
CELLS: POTENTIAL ROLE FOR CB2<br />
2 3 NCTR, Jefferson, AR and RTI International, Research<br />
SELECTIVE LIGANDS AS<br />
Triangle Park, NC.<br />
IMMUNOSUPPRESSIVE AGENTS. C. A. Lombard<br />
M. Nagarkatti 1 and P. S. Nagarkatti 2 . 1 Microbiology<br />
and Immunology, MCV Campus, Virginia<br />
March 7<br />
Commonwealth University, Richmond, VA and<br />
PM<br />
2 Pharmacology and <strong>Toxicology</strong>, MCV Campus, Virginia<br />
Commonwealth University, Richmond, VA.<br />
MECHANISMS OF IMMUNOTOXICITY<br />
#369 4:04 THE ENDOGENOUS CANNABINOID, 2-<br />
ARACHIDONYL-GLYCEROL, SUPPRESSES NF-<br />
Mitzi Nagarkatti, Virginia Commonwealth University,<br />
AT NUCLEAR TRANSLOCATION AND<br />
David Shepherd, University <strong>of</strong> Montana, Missoula, MT.<br />
INTERFERON-γ PRODUCTION. B. L. Kaplan 1,2 ,<br />
GENE EXPRESSION ALTERATIONS IN<br />
Ouyang 1 , C. E. Rockwell 1 , G. K. Rao 1,2 and N. E.<br />
IMMUNE SYSTEM PATHWAYS FOLLOWING<br />
Kaminski 1,2 . 1 Pharmacology and <strong>Toxicology</strong>, Michigan<br />
EXPOSURE TO IMMUNOSUPPRESSIVE<br />
State University, East Lansing, MI and 2 Center for<br />
CHEMICALS. R. M. Patterson 1 , N. Walker 1 , S.<br />
Integrative <strong>Toxicology</strong>, Michigan State University, East<br />
Baker 2 , T. Dickinson 2 , K. White 3 , D. Musgrove 3 , S.<br />
Lansing, MI.<br />
Harrison 1 and D. R. Germolec 1 . 1 NIEHS, Research<br />
Triangle Park, NC, 2 Illumina, Inc., San Diego, CA and<br />
3 VCU, Richmond, VA.<br />
,<br />
1 ,<br />
Y.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 75
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RISK ASSESSMENT I<br />
Chairperson(s): Moiz Mumtaz, ATSDR, Chamblee, GA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#370 CONCEPTUAL PRINCIPLES FOR UTILIZING<br />
OMIC TECHNOLOGIES IN MECHANISTIC<br />
RISK ASSESSMENT. C. Borgert 1,2 , P. Guiney 3 , G.<br />
Casella 4 and K. Shiverick 5 . 1 Applied Pharmacology<br />
<strong>Toxicology</strong> Inc., Gainesville, FL, 2 Department <strong>of</strong><br />
Physiological Sciences, University <strong>of</strong> FL College <strong>of</strong><br />
Veterinary Medicine, Gainesville, FL, 3 S.C. Johnson &<br />
Son, Inc., University <strong>of</strong> FL College <strong>of</strong> Veterinary<br />
Medicine, Racine, WI, 4 Department <strong>of</strong> Statistics,<br />
University <strong>of</strong> FL College <strong>of</strong> Veterinary Medicine,<br />
Gainesville, FL and 5 University <strong>of</strong> FL College <strong>of</strong><br />
Medicine, Gainesville, FL.<br />
#371 USE OF GENOMICS DATA TO PREDICT MODE<br />
OF ACTION IN CHEMICAL HAZARD<br />
CHARACTERIZATION. I. Pagan 1 and B. Sen 2,3 .<br />
1 NCEA/ORD, U.S. EPA, Research Triangle Park, NC,<br />
2 National Research Council, Washington, DC and<br />
3 ECD/ORD, U.S. EPA, Research Triangle Park, NC.<br />
#372 ASSIGNING OCCUPATIONAL HAZARD<br />
CATEGORIES (OHCS) FOR MATERIALS USED<br />
AND SYNTHESIZED IN THE<br />
PHARMACEUTICAL INDUSTRY. F. J. Guerriero 1 ,<br />
C. W. Seaman 2 , M. J. Olson 3 , M. W. Abromovitz 1 and<br />
G. L. Sprague 1 . 1 GlaxoSmithKline, King <strong>of</strong> Prussia, PA,<br />
2 GlaxoSmithKline, Ware, Herts, United Kingdom and<br />
3 GlaxoSmithKline, Research Triangle Park, NC.<br />
#373 USING STRUCTURE-ACTIVITY<br />
RELATIONSHIPS FOR CHEMICAL HAZARD<br />
SCREENING UNDER THE SUSTAINABLE<br />
FUTURES PROGRAM. L. T. Haber 1 , A. Maier 1 , E.<br />
Becker 2 and J. Santory 3 . 1 <strong>Toxicology</strong> Excellence for<br />
Risk Assessment (TERA), Cincinnati, OH, 2 Consortium<br />
for Environmental Risk Management (CERM),<br />
Evansville, IN and 3 CERM, Pittsburgh, PA.<br />
#374 SCIENTIFIC CRITERIA TO TEST INGREDIENTS<br />
ADDED TO CIGARETTES. D. M. Byrd, A.<br />
Brownawell, M. Falk, R. Feldman, K. Lewis and P.<br />
Nixon. LSRO, Bethesda, MD.<br />
#375 AN INTEGRATED DECISION TOOL FOR<br />
EVALUATING CHEMICAL SAFETY IN<br />
LABORATORY RESEARCH STUDIES<br />
INVOLVING ANIMALS. A. Maier 1 , J. Utrecht 2 , C.<br />
Pittinger 4 , J. Stewart 3 and A. Parker 1 . 1 <strong>Toxicology</strong><br />
Excellence for Risk Assessment (TERA), Cincinnati,<br />
OH, 2 University <strong>of</strong> Cincinnati, Cincinnati, OH,<br />
3 Environmental Health and Engineering, Newton, MA<br />
and 4 Exponent, Inc., Cincinnati, OH.<br />
#376 REAL WORLD TOXICOLOGY: A FRAMEWORK<br />
FOR EVALUATING TORT CLAIMS IN THE<br />
COURTROOM. S. M. Bobst 1 , N. Zheng 2 and F.<br />
Thomas 2 . 1 CERATOX, Houston, TX and 2 RAM Group<br />
Inc., Houston, TX. Sponsor: J. Jabbour.<br />
#377 A FRAMEWORK/APPROACH FOR<br />
INCORPORATING PBPK MODELING INTO<br />
CUMULATIVE RISK ASSESSMENT OF<br />
CHEMICAL MIXTURES. R. S. Yang 1 , J. E.<br />
Dennison 1 and J. C. Lipscomb 2 . 1 Quantitative and<br />
Computational <strong>Toxicology</strong> Group, Center for<br />
Environmental <strong>Toxicology</strong> and Technology, Colorado<br />
State University, Fort Collins, CO and 2 U.S. EPA,<br />
ORD/NCEA, Cincinnati, OH.<br />
#378 DEVELOPMENT OF A CHILDREN’S HEALTH<br />
RISK ASSESSMENT FRAMEWORK USING A<br />
LIFE-STAGE APPROACH. S. Barone 1 , R. Brown 2,1 ,<br />
S. Euling 1 , E. Cohen-Hubal 3 , C. A. Kimmel 1 , S.<br />
Makris 1 , J. Moya 1 , S. G. Selevan 1 , B. Sonawane 1 , T.<br />
Thomas 4,1 and C. M. Thompson 4,1 . 1 NCEA, U.S. EPA,<br />
Washington, DC, 2 ASPH, Association <strong>of</strong> Schools <strong>of</strong><br />
Public Health, Washington, DC, 3 NERL, U.S. EPA,<br />
Research Triangle park, NC and 4 AAAS, American<br />
Association for Advancement Science, Washington, DC.<br />
#379 CASE STUDIES: DEVELOPING A DECISION-<br />
MAKING FRAMEWORK FOR OCCUPATIONAL<br />
HEALTH AND SAFETY CLEARANCE OF NEW<br />
CHEMICALS. S. Kim 1 , A. Maier 2 , P. J. Hakkinen 2,3 ,<br />
A. Wullenweber 2 , D. A. Seid 1 and L. T. Haber 2 .<br />
1 2 Applied Biosystems, Foster City, CA, <strong>Toxicology</strong><br />
Excellence for Risk Assessment, Cincinnati, OH and<br />
3 Institute for Health and Consumer Protection, Physical<br />
and Chemical Exposure Unit, European Commission,<br />
Joint Research Centre, Ispra, Italy.<br />
#380 A RETROSPECTIVE REVIEW OF STUDIES<br />
UTILIZING GAVAGE DOSING OF PRE-<br />
WEANING RATS DEMONSTRATES NO<br />
ADVERSE CONSEQUENCES OF DOSING<br />
PROCEDURES. S. L. Makris 1 , E. Mendez 2 and K. C.<br />
Raffaele 3 . 1 ORD/NCEA, U.S. EPA, Washington, DC,<br />
2 3 OPP, U.S. EPA, Washington, DC and OPP, U.S. EPA,<br />
Washington, DC.<br />
#381 RISK ASSESSMENT IN NEPHROTOXICOLOGY<br />
– SENSITIVITY OF RENAL TESTS. P. A. Potnis 1 ,<br />
A. Maier 1 and T. L. Guidotti 1 . 1 Environmental and<br />
Occupational Health, The George Washington<br />
University, Washington, DC, 2 <strong>Toxicology</strong>, <strong>Toxicology</strong><br />
Excellence for Risk Assessment (TERA), Cincinnati,<br />
OH and 3 Environmental and Occupational Health, The<br />
George Washington University, Washington, DC.<br />
#382 RELEVANCE OF RODENT FORESTOMACH<br />
TUMORS IN CANCER RISK ASSESSMENT. D.<br />
Proctor and S. Hong. Exponent, Irvine, CA.<br />
#383 APPLICATION OF QSTRS TO SELECT A<br />
SURROGATE CHEMICAL FOR A CHEMICAL<br />
LACKING ORAL TOXICITY DATA. R. M. Bruce 1 ,<br />
R. Venkatapathy 2 , C. Moudgal 1 and H. Choudhury 1 .<br />
1 2 NCEA, U.S. EPA, Cincinnati, OH and ORISE/NCEA-<br />
U.S. EPA, Cincinnati, OH.<br />
#384 A HISTORICAL PERSPECTIVE ON LONG-<br />
TERM ANIMAL BIOASSAYS. T. A. Lewandowski 1 ,<br />
B. D. Beck 2 , L. A. Beyer 2 and L. R. Rhomberg 2 .<br />
1 Gradient Corporation, Seattle, WA and<br />
2 Gradient<br />
Corporation, Cambridge, MA.<br />
76<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#385 THE T25 METHOD FOR CANCER HAZARD<br />
CHARACTERISATION. COMPARISON WITH<br />
HAZARD CHARACTERISATION BASED ON<br />
EPIDEMIOLOGY. T. Sanner 1 and E. Dybing 2 .<br />
1 Institute <strong>of</strong> Cancer Research, The Norwegian Radium<br />
Hospital, Oslo, Norway and 2 Division <strong>of</strong> Environmental<br />
Medicine, Norwegian Institute <strong>of</strong> Public Health, Oslo,<br />
Norway.<br />
#386 DOSE-RELATED ISSUES IN THE DESIGN AND<br />
INTERPRETATION OF CHRONIC TOXICITY<br />
AND CARCINOGENICITY STUDIES IN<br />
RODENTS. L. Rhomberg 1 , S. Olin 2 and I. Working<br />
Group 2 . 1 Gradient Corporation, Cambridge, MA and<br />
2 Risk Science Institute, International Life Sciences<br />
Institute, Washington, DC.<br />
#387 STATISTICAL PROPERTIES OF CARCINOGEN<br />
THRESHOLD ESTIMATES USING LOG-LINEAR<br />
REGRESSION. D. A. Dankovic and M. T. Wheeler.<br />
Risk Evaluation Branch, CDC/NIOSH, Cincinnati, OH.<br />
#388 AN EMPIRICAL APPROACH TO DOSE-<br />
DURATION-RESPONSE MODELING AND TIME-<br />
SCALING. K. G. Brown 1 and G. L. Foureman 2 .<br />
1 2 KBinc, Chapel Hill, NC and NCEA/ORD, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#389 STATISTICAL METHODOLOGY FOR THE<br />
SIMULTANEOUS ANALYSIS OF MULTIPLE<br />
TYPES OF OUTCOMES IN NONLINEAR<br />
THRESHOLD MODELS. T. C<strong>of</strong>fey 1 , C. Gennings 1<br />
and V. C. Moser 2 . 1 Biostatistics, Virginia<br />
Commonwealth University, Richmond, VA and<br />
2 ORD/NHEERL, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#390 TOXICITY ESTIMATION OF LOW LEVEL<br />
SHORT-TERM EXPOSURES TO CHEMICAL<br />
MIXTURES. M. M. Mumtaz 1 , C. T. De Rosa 1 , H.<br />
Pohl 1 , D. M<strong>of</strong>fett 1,2 , H. A. El-Masri 1 and B. A. Fowler 1 .<br />
1 2 Division <strong>of</strong> <strong>Toxicology</strong>, ATSDR, Atlanta, GA and US<br />
Public Health Service, Atlanta, GA.<br />
#391 PURITY ANALYSES FOR TOXICOLOGY<br />
STUDIES–A CASE STUDY WITH<br />
ANTHRAQUINONE. S. Graves 1 , N. South 1 and C.<br />
Smith 2 . 1 <strong>Toxicology</strong> Columbus, Battelle, Columbus, OH<br />
and 2 NIEHS, Research Triangle Park, NC.<br />
#392 THE TCDD TEQ IN HUMAN BLOOD FROM<br />
DIETARY VS. ANTHROPOGENIC DIOXINS: A<br />
DIETARY STUDY. M. A. harris 1 and B. Finley 2 .<br />
1 2 Exponent, Houston, TX and Exponent, Santa Rosa,<br />
CA. Sponsor: L. Haws.<br />
#393 RELATIVE POTENCIES OF THREE DIOXIN<br />
CONGENERS BASED ON LIVER FOCI<br />
FORMATION ASSAY AND LIVER<br />
CONCENTRATIONS IN RAT AND HUMAN<br />
ESTIMATED BY PBPK MODELS. W. Maruyama<br />
and Y. Aoki. Research Center for Environmental Risk,<br />
National Institute for Environmental Studies, Tsukuba,<br />
Japan.<br />
#394 VARIABILITY AND UNCERTAINTY<br />
DISTRIBUTIONS FOR THE CARCINOGENIC<br />
POTENCY OF 2, 3, 7, 8-TCDD. E. Crouch.<br />
Cambridge Environmental Inc., Cambridge, MA.<br />
Sponsor: L. Green.<br />
#395 COMPARING ENVIRONMENTALLY RELEVANT<br />
PCBs TO TCDD IN CYP1A2 NULL AND<br />
WILDTYPE MICE. D. E. Burgin 1,2 , J. J. Diliberto 3<br />
and L. S. Birnbaum 3 . 1 National Center for<br />
Environmental Economics, U.S. EPA, Washington, DC,<br />
2 <strong>Toxicology</strong>, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC and 3 ORD/NHEERL/ETD, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#396 CANCER POTENCY ESTIMATION FOR<br />
ACRYLAMIDE. M. S. Sandy, T. A. McDonald and L.<br />
Zeise. Office <strong>of</strong> Environmental Health Hazard<br />
Assessment, California EPA, Oakland, CA.<br />
#397 ACRYLAMIDE TOXICITY–IS A REAPPRAISAL<br />
NECESSARY? C. Siegers 1 and J. B. Schulze 2 .<br />
1 Institute <strong>of</strong> Experimental and Clinical Pharmacology<br />
and <strong>Toxicology</strong>, Luebeck, Germany and 2 Office <strong>of</strong> the<br />
Dean, Medical Faculty, Frankfurt, Germany.<br />
#398 DOSE-RESPONSE MODELING OF IN VIVO<br />
GENOTOXICITY DATA: ITS RELEVANCE TO<br />
RISK ASSESSMENT ILLUSTRATED BY AN<br />
APPLICATION TO ACRYLAMIDE. B. Allen 1 , E.<br />
Zeiger 2 , M. Friedman 3 and A. Shipp 4 . 1 Environ Health<br />
Sciences Institute, Chapel Hill, NC, 2 Errol Zeiger<br />
Consulting, Chapel Hill, NC, 3 UNDMJ, Newark, NJ<br />
and 4 Environ Health Sciences Institute, Ruston, LA.<br />
#399 ISSUES RELATING TO THE DERIVATION OF<br />
ORAL TOXICITY VALUES FOR<br />
CHLORDECONE. J. A. Stickney 1 , M. H. Follansbee 1 ,<br />
D. W. Wohlers 2 , P. R. McClure 2 , M. Odin 2 and P. M.<br />
McGinnis 3 . 1 Environmental Science Center, Syracuse<br />
Research Corp, Scarborough, ME, 2 Environmental<br />
Science Center, Syracuse Research Corp, Syracuse, NY<br />
and 3 Environmental Science Center, Syracuse Research<br />
Corp, Philadelphia, PA.<br />
#400 RE-EVALUATION OF THE RISK OF LUNG<br />
CANCER FROM DIESEL EXHAUST EXPOSURE.<br />
T. W. Hesterberg 2 , W. B. Bunn 2 and C. A. Lapin 1 . 1 Lapin<br />
and Associates, Glendale, CA and 2 International Truck<br />
and Engine Corp, Warrenville, IL.<br />
#401 IMPORTANCE OF PEROXISOME<br />
PROLIFERATION IN UNDERSTANDING<br />
POTENTIAL MODE(S) OF ACTION FOR TCE<br />
AND ITS APPLICATION IN RISK ASSESSMENT.<br />
N. Keshava 1 and J. C. Caldwell 1 . 1 Office <strong>of</strong> Research<br />
and Development, U.S. EPA, Washington, DC and<br />
2 Office <strong>of</strong> Research and Development, U.S. EPA,<br />
Washington, DC.<br />
#402 INCORPORATION OF TRICHLOROACETIC<br />
ACID PLASMA BINDING IN HUMAN AND<br />
MOUSE IN TRICHLOROETHYLENE RISK<br />
ASSESSMENT. D. A. Keys 1 , M. H. Lumpkin 2 , J. V.<br />
Bruckner 1 and J. W. Fisher 1 . 1 Interdisciplinary<br />
<strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong> Georgia, Athens,<br />
GA and 2 Clayton Group Services, Inc., Kennesaw, GA.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 77
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#403 USE OF A PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC MODEL FOR<br />
CHLOROFORM TO EVALAUTE<br />
BIOMONITORING DATA. K. H. Liao 1 , R. B.<br />
Conolly 1 , A. M. Mason 2 and Y. Tan 1 . 1 Center for<br />
Computational Systems Biology & Human Health<br />
Assessment, CIIT Centers for Health Research,<br />
Research Triangle Park, NC and 2 Chlorine Chemistry<br />
Council, Arlington, VA.<br />
#404 MONTE CARLO ANALYSIS OF SOURCES OF<br />
VARIABILITY IN CHLOROFORM-INDUCED<br />
HEPATIC CYTOLETHALITY AND<br />
REGENERATIVE PROLIFERATION IN B6C3F1<br />
MICE. Y. Tan and R. B. Conolly. Center for<br />
Computational Systems Biology & Human Health<br />
Assessment, CIIT Centers for Health Research,<br />
Research Triangle Park, NC.<br />
#405 DOSE-RESPONSE MODELING AND<br />
BENCHMARK CALCULATIONS FROM<br />
SPONTANEOUS BEHAVIOR DATA ON MICE<br />
NEONATALLY EXPOSED TO 2, 2′, 4, 4′,<br />
5–PENTABROMODIPHENYL ETHER. S. Sand 1 , D.<br />
von Rosen 2 , P. Eriksson 3 , A. Fredriksson 3 , H. Viberg 3 ,<br />
K. Victorin 1 and A. Falk Filipsson 1 . 1 Institute <strong>of</strong><br />
Environmental Medicine, Karolinska Institutet,<br />
Stockholm, Sweden, 2 Biometry and Informatics,<br />
Swedish University <strong>of</strong> Agricultural Sciences, Uppsala,<br />
Sweden and 3 Enviromental <strong>Toxicology</strong>, Uppsala<br />
University, Uppsala, Sweden.<br />
#406 ADVANTAGES AND LIMITATIONS OF<br />
BENCHMARK DOSE MODELING AND THE<br />
NOAEL/LOAEL APPROACH IN PERFORMING<br />
DOSE-RESPONSE ASSESSMENT BASED ON<br />
SMALL STUDIES: SUBCHRONIC RFD FOR<br />
CHLOROBENZENE AS A CASE STUDY. M. Odin,<br />
P. McClure and P. McGinnis. Environmental Science<br />
Center, Syracuse Research Corp, Syracuse, NY.<br />
#407 BENCHMARK DOSE MODELING OF<br />
DEVELOPMENTAL RESPONSES IN OFFSPRING<br />
OF RATS EXPOSED TO TRICHLOROACETIC<br />
ACID. L. H. Moilanen 1 , P. McClure 1 , D. Wong 2 and P.<br />
McGinnis 1 . 1 Environmental Science Center, Syracuse<br />
Research Corp, Syracuse, NY and 2 Office <strong>of</strong> Research<br />
& Development NCEA/IRIS <strong>Program</strong>, U.S. EPA,<br />
Washington, DC.<br />
#408 EMPIRICAL EVALUATION OF SUFFICIENT<br />
SIMILARITY FOR A MIXTURE OF NINE<br />
HALOACETIC ACIDS (HAA’S) ON CHINESE<br />
HAMSTER OVARY CELL CHRONIC<br />
CYTOTOXICITY USING A FIXED-RATIO RAY<br />
DESIGN. L. G. Stork 1 , C. Gennings 1 , W. Carter, Jr. 1 , R.<br />
Johnson 1 , D. Mays 2 , R. Carchman 3 , J. Simmons 4 and M.<br />
Plewa 5 . 1 Biostatistics, Virginia Commonwealth<br />
University, Richmond, VA, 2 Statistical Sciences and O.<br />
R., VCU, Richmond, VA, 3 Solveritas, LLC, Richmond,<br />
VA, 4 ORD/NHEERL, U.S. EPA, Research Triangle<br />
Park, NC and 5 Crop Sciences, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: EXPOSURE ASSESSMENT/EPIDEMIOLOGY<br />
Chairperson(s): Michael Lumpkin, Clayton Group Services Inc., Kennesaw,<br />
GA and Robert Krieger, University <strong>of</strong> California Riverside, Riverside, CA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#409 EVALUATION OF PROPOSED THRESHOLD<br />
DOSES FOR CHRYSOTILE EXPOSURE AND<br />
RESPIRATORY DISEASE. B. Finley 1 , F. Mowat 2 , R.<br />
Richter 3 , G. Brorby 4 , V. Craven 1 and P. Sheehan 4 .<br />
1 2 Exponent, Santa Rosa, CA, Exponent, Menlo Park,<br />
CA, 3 Exponent, Irvine, CA and 4 Exponent, Oakland,<br />
CA.<br />
#410 CHRYSOTILE ASBESTOS EXPOSURE<br />
ASSOCIATED WITH REMOVAL OF<br />
AUTOMOBILE EXHAUST SYSTEMS (CIRCA<br />
1946-1970). D. J. Paustenbach 1 , A. Madl 1 , K. Clark 1 ,<br />
K. Fehling 1 and T. Lee 2 . 1 ChemRisk, Inc., San<br />
Francisco, CA and 2 Carolina EHS, Lake Wylie, SC, SC.<br />
#411 EXPOSURE RECONSTRUCTION OF<br />
HISTORICAL AIRBORNE BENZENE<br />
CONCENTRATIONS: CASE STUDY OF A DECK<br />
CREWMAN ON BOARD CRUDE OIL AND<br />
CHEMICAL TANKERS. A. Madl 1 , K. Unice 3 , P.<br />
Scott 3 , K. Robinson 2 , P. Scaramella 1 , D. Pyatt 2,4 and D.<br />
Paustenbach 1 . 1 ChemRisk, Inc., San Francisco, CA,<br />
2 3 ChemRisk, Inc., Boulder, CO, ChemRisk, Inc.,<br />
Pittsburgh, PA and 4 University <strong>of</strong> Colorado Health<br />
Sciences Center, Denver, CO.<br />
#412 DIESEL-RELATED BENZENE EXPOSURES<br />
DURING REFUELING OPERATIONS AT TWO<br />
GROCERY DISTRIBUTION CENTERS. M. J.<br />
Fedoruk 1 , T. Smalstig 1 , J. Tran 1 , M. Shum 1 , R. O.<br />
Richter 1 , R. Bronstein 1 and B. D. Kerger 2 . 1 Exponent<br />
Inc., Irvine, CA and 2 Health Science Resource<br />
Integration, Inc., Tallahassee, FL.<br />
#413 OCCUPATIONAL PESTICIDE EXPOSURE<br />
DURING SEED CORN PRODUCTION IN<br />
MICHIGAN. B. Hughes 1 , L. Olsen 2 , P. Hite 3 and P.<br />
Bills 2 . 1 PPPM, MI Department Ag., Lansing, MI, 2 Ent.,<br />
MSU, East Lansing, MI and 3 Lab., MI Department Ag.,<br />
East Lansing, MI.<br />
#414 PESTICIDE EXPOSURE ASSESSMENT:<br />
MOISTURE ENHANCES MALATHION<br />
TRANSFER TO HARVESTER GLOVES AND<br />
CLOTHING, BUT DOES NOT INCREASE<br />
ABSORBED DOSE. R. I. Krieger, X. Zhang, T. Din<strong>of</strong>f,<br />
Y. Chou and S. Acevedo. University <strong>of</strong> California<br />
Riverside, Riverside, CA.<br />
#415 CHEMICAL EXPOSURE ASSESSMENT:<br />
SURFACE DEPOSITION OF ENVIRONMENTAL<br />
TOBACCO SMOKE (ETS). J. J. Keenan, X. Zhang<br />
and R. Krieger. Environmental <strong>Toxicology</strong> <strong>Program</strong> and<br />
Department <strong>of</strong> Entomology, University <strong>of</strong> California,<br />
Riverside, CA.<br />
78<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#416 VALIDATION OF A SURROGATE MIX TO<br />
DETERMINE CONCENTRATION OF<br />
INDIVIDUAL COMPONENTS OF JP-8 IN<br />
AEROSOL AND VAPOR SAMPLES BY GC/MS. K.<br />
Dietzel 1 , J. Campbell 1 , M. Bartlett 2 , M. Witten 3 and J.<br />
Fisher 1 . 1 Interdisciplinary <strong>Toxicology</strong> <strong>Program</strong>,<br />
Univeristy <strong>of</strong> Georgia, Athens, GA, 2 Pharmaceutical<br />
and Biomedical Sciences, University <strong>of</strong> Georgia,<br />
Athens, GA and 3 Pediatrics, Univeristy <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
#417 PHYSICOCHEMICAL CHARACTERISATION OF<br />
COMBUSTION PARTICLES FROM<br />
RESIDENTIAL WOOD SMOKE AND VEHICLE<br />
EXHAUST. A. Kocbach 1 , K. E. Yttri 2 , P. E. Schwarze 1<br />
and E. Namork 1 . 1 Environmental Medicine, Norwegian<br />
Institute <strong>of</strong> Public Health, Oslo, Norway and<br />
2 Department for Chemical Analysis, Norwegian<br />
Institute for Air Research, Kjeller, Norway. Sponsor: E.<br />
Dybing.<br />
#418 COMPARISON OF TRACER METHODS USED<br />
TO MEASURE IN-VEHICLE<br />
CONCENTRATIONS. M. D. Easter 1 , R. Ireson 2 , T.<br />
Hesterberg 3 , M. Lakin 1 and C. Lapin 4 . 1 EnSIGHT,<br />
Walnut Creek, CA, 2 AQM Consulting, Greenbrae, CA,<br />
3 International Truck & Engine Corporation, Chicago, IL<br />
and 4 Lapin & Associates, Los Angeles, CA.<br />
#419 SIMULATION AND ASSESSMENT OF<br />
OCCUPATIONAL EXPOSURES TO<br />
ISOCYANATES AND VOCS DURING<br />
APPLICATION OF A URETHANE PRODUCT<br />
SUITE UNDER WORST-CASE CONDITIONS. M.<br />
H. Lumpkin 1 , V. Runnion 1 , R. Lieckfield 1 , S. D. Paul 1<br />
and R. D. Harbison 2 . 1 Clayton Group Services, Inc.,<br />
Kennesaw, GA and 2 Environmental & Occupational<br />
Health, College <strong>of</strong> Public Health, University <strong>of</strong> South<br />
Florida, Tampa, FL.<br />
#420 OCCUPATIONAL EXPOSURE TO ULTRAFINE<br />
PARTICLES AND POLYCYCLIC AROMATIC<br />
HYDROCARBONS FROM CANDLE EMISSIONS.<br />
D. Silver and R. D. Harbison. University <strong>of</strong> South<br />
Florida, Tampa, FL.<br />
#421 EXPOSURE ASSESSMENT FOR PERCHLORATE<br />
IN MILK. D. Proctor. Exponent, Irvine, CA.<br />
#422 CURRENT ALCOHOL USE IS ASSOCIATED<br />
WITH A REDUCED RISK OF HOT FLASHES IN<br />
PERI-MENOPAUSAL WOMEN. C. Schilling 1 , L.<br />
Gallicchio 2 , S. Miller 2 , J. Babus 1 , L. Lewis 1 , H. Zacur 2<br />
and J. A. Flaws 1 . 1 University <strong>of</strong> Maryland, Baltimore,<br />
MD and 2 Johns Hopkins University, Baltimore, MD.<br />
#423 ENVIRONMENTAL EXPOSURE TO CADMIUM<br />
AT A LEVEL INSUFFICIENT TO INDUCE<br />
RENAL TUBULAR DYSFUNCTION DOES NOT<br />
AFFECT BONE DENSITY AMONG FEMALE<br />
JAPANESE FARMERS. F. Kayama 1,2 , H.<br />
Horiguchi 1,2 , E. Oguma 1,2 , S. Sasaki 3 , K. Miyamaoto 1 ,<br />
Y. Ikeda 1 and M. Munehito 1 . 1 Environmental Medicine,<br />
Jichi Medical School, Kawachi-Gun, Tochigi, Japan,<br />
2 CREST, JST, Kawaguchi, Saitama, Japan and<br />
3 National Institute <strong>of</strong> Health and Nutrition, Tokyo,<br />
Japan. Sponsor: T. Yoshida.<br />
#424 HEALTH EFFECTS REPORTED IN TEXAS<br />
HOMES WITH VISIBLE MOLD AND/OR WATER<br />
DAMAGE. J. Gandy 1,2 and A. J. Harris 1 . 1 Center for<br />
<strong>Toxicology</strong> and Environmental Health, Little Rock, AR<br />
and 2 College <strong>of</strong> Public Health, Department <strong>of</strong><br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Arkansas<br />
School for Medical Sciences, Little Rock, AR.<br />
#425 AN INVESTIGATION OF HOME DAMPNESS<br />
AND ADVERSE HEALTH EFFECTS ON A<br />
NATIVE AMERICAN RESERVATION. A. L. Stock,<br />
K. Davis, C. Brown, J. Sarisky and C. Blanton. NCEH,<br />
Centers For Disease Control and Prevention, Atlanta,<br />
GA.<br />
#426 UNIVOCAL DECISION RULES FOR THE<br />
ASSESSMENT OF CHRONIC SOLVENT-<br />
INDUCED ENCEPHALOPATHY; A PROPOSAL.<br />
M. Verberk 1 , J. van der Hoek 4 , E. Wekking 3,2 , M. van<br />
Hout 5,2 , G. Hageman 3,2 and G. van der Laan 2 . 1 Coronel<br />
Institute for Occupational Medicine, Academic Medical<br />
Center, Amsterdam, Netherlands, 2 Netherlands Center<br />
for Occupational Diseases, Academic Medical Center,<br />
Amsterdam, Netherlands, 3 Psychiatry, Academic<br />
Medical Center, Amsterdam, Netherlands, 4 Neurology,<br />
Medical Spectrum Twente Hospital Group, Enschede,<br />
Netherlands and 5 Clinical Psychology, Medical<br />
Spectrum Twente Hospital Group, Enschede,<br />
Netherlands. Sponsor: P. Bogaard.<br />
#427 MATERNAL DDE SERUM LEVELS AND<br />
NEUROLOGICAL DEVELOPMENT IN INFANTS.<br />
PRELIMINARY FINDINGS. L. Torres-Sanchez 1 , L.<br />
Lopez-Carrillo 1 , L. Schnaas 2 , E. Osorio 2 , M.<br />
Hernandez 2 , R. Garcia 3 and M. Cebrian 3 . 1 INSP,<br />
Morelos, Mexico, 2 IN Perinatologia, Mexico City,<br />
Mexico and 3 <strong>Toxicology</strong>, CINVESTAV-IPN, Mexico<br />
City, Mexico.<br />
#428 ASSESSING THE PUBLIC HEALTH IMPACTS<br />
OF THE 1991 GULF WAR IN SAUDI ARABIA: A<br />
QUALITATIVE RISK ASSESSMENT APPROACH.<br />
H. I. Williams 1 , A. Wiman 1 , C. Williams 1 , C. Stineman 2 ,<br />
R. Freeman 3 , R. V. Lee 4 , M. Bell 5 , M. J. Symons 6 , S.<br />
Kim 6 , R. White 6 , J. Samet 6 and P. Breysse 6 . 1 Ecology<br />
and Environment, Inc., Tallahassee, FL, 2 Ecology and<br />
Environment, Inc., Chicago, IL, 3 TERRA, Inc.,<br />
Tallahassee, FL, 4 School <strong>of</strong> Medicine and Biomedical<br />
Sciences, State University <strong>of</strong> New York at Buffalo,<br />
Buffalo, NY, 5 Yale School <strong>of</strong> Forestry and<br />
Environmental Studies, New Haven, CT and 6 Johns<br />
Hopkins Bloomberg School <strong>of</strong> Public Health,<br />
Baltimore, MD.<br />
#429 GETTING THE LEAD DOSE-RESPONSE CURVE<br />
RIGHT: IMPLICATIONS FOR PUBLIC HEALTH<br />
AND POLICY. S. J. Rothenberg 1 , J. C. Rothenberg 2<br />
and D. A. Fox 3 . 1 Instituto Nacional de Salud Publica,<br />
Cuernavaca, Morelos, Mexico, 2 University <strong>of</strong> Sydney,<br />
Camperdown, NSW, Australia and 3 University <strong>of</strong><br />
Houston, Houston, TX.<br />
#430 MECHANISMS OF METAL-ASSOCIATED<br />
VASCULAR DISEASE. E. K. Silbergeld, A. Navas-<br />
Acien, B. S. Schwartz, R. Sharrett, E. Sharrett and E.<br />
Guallar. Johns Hopkins University Bloomberg School<br />
Public Health, Baltimore, MD.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 79
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#431 CATEGORIZATION OF THE ASSOCIATIONS<br />
BETWEEN EXPOSURE TO THE HERBICIDES<br />
USED IN VIETNAM OR THEIR<br />
CONTAMINANTS AND HEALTH OUTCOMES. J.<br />
Cohen and M. Catlin. The National Academies,<br />
Washington, DC.<br />
#432 THE IMPACT OF REDUCTION OF THE<br />
OCCUPATIONAL EXPOSURE LIMIT FOR<br />
FORMALDEHYDE IN QUEBEC: A RE-<br />
EVALUATION OF HEALTH RISKS. N. Noisel, M.<br />
Bouchard and G. Carrier. Sante Environnementale &<br />
Sante Au Travail, Universite de Montreal, Montreal,<br />
QC, Canada.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RESPIRATORY TRACT I–PULMONARY,<br />
CARDIOVASCULAR, AND IMMUNE EFFECTS OF PM<br />
CHAIRPERSON(S): PRAMILA SINGH, U.S. EPA, RESEARCH TRIANGLE<br />
PARK, NC AND MICHELLE V. FANUCCHI, UC DAVIS, DAVIS, CA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#433 EFFECTS OF INHALED COMBUSTION-<br />
DERIVED PARTICULATE MATTER ON INDICES<br />
OF CARDIAC, PULMONARY, AND<br />
THERMOREGULATORY FUNCTION IN<br />
SPONTANEOUSLY HYPERTENSIVE RATS. L. B.<br />
Wichers 1 , W. H. Rowan 2 , J. P. Nolan 2 , U. P. Kodavanti 2 ,<br />
M. J. Schladweiler 2 , A. D. Ledbetter 2 , D. L. Costa 2 and<br />
W. P. Watkinson 2 . 1 SPH, UNC, Chapel Hill, NC and<br />
2 ORD/NHEERL/ETD/PTB, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#434 CARDIOPULMONARY EFFECT OF<br />
PARTICULATE MATTERS ON DIABETIC RATS:<br />
FROM CAPS TO ULTRAFINE PARTICLES. Y. Lei<br />
and T. Cheng. College <strong>of</strong> Public Health, National<br />
Taiwan University, Taipei, Taiwan. Sponsor: T. Ueng.<br />
#435 TOXICOGENOMIC EXPRESSION PROFILES OF<br />
SPONTANEOUSLY HYPERTENSIVE RATS<br />
EXPOSED TO CONCENTRATED AMBIENT<br />
PARTICLES. Y. Lei and T. Cheng. Public Health,<br />
National Taiwan University, Taipei, Taiwan. Sponsor:<br />
T. Ueng.<br />
#436 TIME-COURSE OF INFLAMMATION AND<br />
TISSUE DAMAGE IN THE MOUSE LUNG<br />
CAUSED BY FINE PARTICULATE MATTER<br />
FROM SIX EUROPEAN CITIES (PAMCHAR). M.<br />
S. Happo 1,2 , R. O. Salonen 1 , A. I. Halinen 1 , P. Jalava 1,2<br />
and M. Hirvonen 1 . 1 Department <strong>of</strong> Environmental<br />
Health, National Public Health Institute, Kuopio,<br />
Finland and 2 University <strong>of</strong> Kuopio, Kuopio, Finland.<br />
Sponsor: M. Viluksela.<br />
#437 EXPOSURE TO CONCENTRATED AMBIENT<br />
PARTICLES DOES NOT AFFECT<br />
ENDOTHELIAL VASOMOTOR FUNCTION IN<br />
PATIENTS WITH ISCHEMIC HEART DISEASE.<br />
N. L. Mills 1 , D. E. Newby 1 , S. D. Robinson 1 , D.<br />
Anderson 1 , E. Freney 1 , D. Robert 1 , N. A. Boon 1 , W.<br />
MacNee 1 , K. Donaldson 1 and F. Cassee 2 . 1 Centre for<br />
Cardiovascular Science, ELEGI Colt Research<br />
Laboratories or Department <strong>of</strong> Chemistry, University <strong>of</strong><br />
Edinburgh, Edinburgh, United Kingdom and 2 Centre for<br />
Environmental Health Research, National Institute for<br />
Public Health and the Environment, Bilthoven,<br />
Netherlands.<br />
#438 EXPOSURE TO CONCENTRATED AMBIENT<br />
PARTICLES IN DETROIT ALTERS HEART RATE<br />
VARIABILITY IN SPONTANEOUSLY<br />
HYPERTENSIVE RATS. J. G. Wagner 1 , L. B.<br />
Wichers 2 , M. Morishita 3 , A. C. Rohr 4 , G. J. Keeler 3 and<br />
J. R. Harkema 1 . 1 Michigan State University, East<br />
Lansing, MI, 2 U.S. EPA -NHEERL, Research Triangle<br />
Park, NC, 3 University Michigan, Ann Arbor, MI and<br />
4 Electrical Power Research Inst, Palo Alto, CA.<br />
#439 EXPOSURE TO CONCENTRATED AMBIENT<br />
PARTICLES IN DETROIT, MICHIGAN CAUSES<br />
HEART RATE AND THERMOREGULATORY<br />
CHANGES IN SPONTANEOUSLY<br />
HYPERTENSIVE AND WISTAR-KYOTO RATS.<br />
A. C. Rohr 1 , J. G. Wagner 2 , M. Morishita 3 , G. J.<br />
Keeler 3 and J. R. Harkema 2 . 1 EPRI, Palo Alto, CA,<br />
2 Michigan State University, East Lansing, MI and<br />
3 University <strong>of</strong> Michigan, Ann Arbor, MI.<br />
#440 SUBCHRONIC EFFECTS OF CONCENTRATED<br />
AMBIENT PARTICLES (CAPS) IN SENESCENT<br />
MICE (AKR). Q. LI and L. Chen. Environmental<br />
Health, NYU School <strong>of</strong> Medicine, Tuxedo, NY.<br />
#441 CARDIAC INJURY FROM LONG-TERM<br />
EPISODIC EXPOSURE TO PARTICULATE<br />
MATTER (PM): SOLUBLE COMPONENTS OR<br />
SOLID PARTICLES? U. P. Kodavanti 1 , M. C.<br />
Schladweiler 1 , A. D. Ledbetter 1 , J. McGee 1 , P. S.<br />
Gilmour 2 , W. P. Watkinson 1 , D. C. Christiani 3 , D. L.<br />
Costa 1 , R. H. Jaskot 1 , J. H. Richards 1 and A. Nyska 4 .<br />
1 ETD/NHEERL/ORD, U.S. EPA, Research Triangle<br />
Park, NC, 2 CEMALB, UNC, Chapel Hill, NC, 3 HSPH,<br />
Boston, MA and 4 NIEHS, Research Triangle Park, NC.<br />
#442 HEART RATE CHANGES IN 24-MONTH OLD<br />
FISHER 344 RATS EXPOSED TO<br />
CONCENTRATED PARTICULATE MATTER<br />
(PM2.5) CLOSE TO A FREEWAY IN DIAMOND<br />
BAR, CA. A. K. hamade, T. Lam and M. T. Kleinman.<br />
University <strong>of</strong> California, Irvine, CA. Sponsor: H.<br />
Hamadeh.<br />
#443 EFFECTS OF ON-ROAD AEROSOLS IN AGED<br />
RATS. A. Elder 1 , N. Corson 1 , P. Mercer 1 , R. Gelein 1 , J.<br />
Finkelstein 2 , P. Hopke 3 , W. Watts 4 , D. Kittelson 4 and G.<br />
Oberdorster 1 . 1 Environment Med., University <strong>of</strong><br />
Rochester, Rochester, NY, 2 Ped., University <strong>of</strong><br />
Rochester, Rochester, NY, 3 Chem. Eng., Clarkson<br />
University, Potsdam, NY and 4 Mech. Eng., University<br />
<strong>of</strong> Minnesota, Minneapolis, MN.<br />
80<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#444 COLLECTION, AEROSOLIZATION, AND<br />
CHARACTERIZATION OF PAVED ROAD DUST<br />
FOR AN INHALATION TOXICITY STUDY. J.<br />
McDonald, E. Barr and J. L. Mauderly. <strong>Toxicology</strong>,<br />
Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
#445 CHEMICAL, MICROBIOLOGICAL AND<br />
TOXICOLOGICAL CHARACTERIZATION OF<br />
FINE PARTICULATE MATTER (PM2.5) FROM<br />
AN INDOOR ENVIRONMENT IN PUERTO RICO.<br />
A. Gioda 1 , E. Fuentes-Mattei 2,1 , B. Bolanos 2 and B. D.<br />
Jimenez-Velez 2,1 . 1 Center <strong>of</strong> Environmental and<br />
Toxicological Research-UPR Medical Science Campus,<br />
San Juan, PR, Puerto Rico and 2 Biochemistry, UPR<br />
Medical Science Campus, San Juan, PR, Puerto Rico.<br />
#446 HIGH NO2/NOX RATIO IN DIESEL ENGINE<br />
EMISSION AEROSOL MAY REPRESENT A<br />
MORE IMPORTANT ACUTE TOXIC TRIGGER<br />
THAN PARTICULATE MATTER (PM) FOR<br />
LUNG TISSUE. J. MORIN 1 , A. Bion 1,2 , V. Keravec 2,1<br />
and F. Dionnet 2 . 1 INSERM U644, Rouen, France and<br />
2 CERTAM, Saint Etienne du Rouvray, France. Sponsor:<br />
R. FORSTER.<br />
#447 EFFECTS OF DIESEL EXHAUST ON TLR3<br />
SIGNALING IN RESPIRATORY EPITHELIAL<br />
CELLS. J. M. Ciencewicki 1 , M. Madden 3,1 and I.<br />
Jaspers 2,1 . 1 Curriculum <strong>of</strong> <strong>Toxicology</strong>, University <strong>of</strong><br />
North Carolina, Chapel Hill, NC, 2 Pediatrics, University<br />
<strong>of</strong> North Carolina, Chapel Hill, NC and 3 Human Studies<br />
Division, U.S. EPA, Chapel Hill, NC.<br />
#448 NEUROTROPHIN RECEPTOR BLOCKADE<br />
ATTENUATES DIESEL EXHAUST<br />
PARTICULATE MATTER (DEP)<br />
ENHANCEMENT OF ALLERGIC RESPONSES. A.<br />
K. Farraj 1,2 , N. Haykal-Coates 2 , A. D. Ledbetter 2 , P. A.<br />
Evansky 2 and S. H. Gavett 2 . 1 Molecular and Biomedical<br />
Sciences, North Carolina State University, Raleigh, NC<br />
and 2 Experimental <strong>Toxicology</strong> Division, NHEERL,<br />
ORD, U.S. EPA, Research Triangle Park, NC.<br />
#449 YM1/2 CHITINASE PROTEINS IN MURINE<br />
NASAL EPITHELIUM AFTER A 13-WEEK<br />
INHALATION EXPOSURE TO ULTRAFINE<br />
CARBON BLACK PARTICLES. J. R. Harkema 1 , P.<br />
Santhanam 1 , J. G. Wagner 1 , L. A. Bramble 1 , A. P.<br />
Elder 2 and G. Oberdorster 2 . 1 Pathobiology and<br />
Diagnostic Invesitgation, Michigan State University,<br />
East Lansing, MI and 2 Environmental Medicine,<br />
University <strong>of</strong> Rochester, Rochester, NY.<br />
#450 PARTICLE SURFACE AREA AND PARTICLE<br />
NUMBER, BUT NOT PARTICLE MASS,<br />
PREDICT THE ADJUVANT EFFECT OF<br />
PARTICLES ON ALLERGIC RESPONSES IN<br />
MICE. U. C. Nygaard, M. Samuelsen, A. Aase and M.<br />
Lovik. Environmental Immunology, Norwegian Institute<br />
<strong>of</strong> Public Health, Oslo, Norway. Sponsor: E. Dybing.<br />
#451 CHEMICAL CHARACTERISTICS AND<br />
TOXICITY OF POLAR ORGANIC EXTRACT OF<br />
DIESEL EXHAUST PARTICLES. T. Kobayashi 1 , H.<br />
Shima 1 and E. Koike 2 . 1 Environmental Health Sciences<br />
Division, National Institute for Environmental Studies,<br />
Tsukuba, Ibaragi, Japan and 2 PM2.5 and DEP Research<br />
Project, National Institute for Environmental Studies,<br />
Tsukuba, Ibaragi, Japan. Sponsor: S. Hirano.<br />
#452 ORGANIC EXTRACT OF DIESEL EXHAUST<br />
PARTICLES STIMULATES EXPRESSION OF IA<br />
AND COSTIMULATORY MOLECULES<br />
ASSOCIATED WITH ANTIGEN PRESENTATION<br />
IN RAT PERIPHERAL BLOOD MONOCYTES<br />
BUT NOT ALVEOLAR MACROPHAGES. E.<br />
KOIKE 1 and T. KOBAYASHI 2 . 1 PM2.5 and DEP<br />
Research Project, National Institute for Environmental<br />
Studies, Tsukuba, Ibaraki, Japan and 2 Environmental<br />
Health Sciences Division, National Institute for<br />
Environmental Studies, Tsukuba, Ibaraki, Japan.<br />
Sponsor: S. Hirano.<br />
#453 WOOD SMOKE PARTICLES INCREASE<br />
ALLERGIC RESPONSES IN MICE, BUT LESS<br />
THAN DIESEL EXHAUST PARTICLES (DEP). M.<br />
Samuelsen, U. C. Nygaard and M. Lovik. Norwegian<br />
Institute <strong>of</strong> Public Health, Oslo, Norway. Sponsor: E.<br />
Dybing.<br />
#454 COMPARISON OF PULMONARY TOXICITY<br />
BETWEEN HEALTHY SPRAGUE-DAWLEY RATS<br />
AND SPONTANEOUSLY HYPERTENSIVE RATS<br />
EXPOSED TO DIESEL EXHAUST PARTICLES.<br />
W. Chang, Y. Lei and T. Cheng. College <strong>of</strong> Public<br />
Health, Institute <strong>of</strong> Occupational Medicine and<br />
Industrial Hygiene, Taipei, Taiwan. Sponsor: T. Ueng.<br />
#455 APOE MOUSE MODEL OF ATHEROSCLEROSIS<br />
CONFERS SUSCEPTIBILITY TO<br />
EXTRAPULMONARY EFFECTS OF DIESEL<br />
EXHAUST. M. J. Campen, J. Seagrave, L. Blair, S.<br />
Lucas, A. Gigliotti, M. Reed and J. McDonald.<br />
<strong>Toxicology</strong>, Lovelace Respiratory Research Institute,<br />
Albuquerque, NM.<br />
#456 RELATIVE EFFICACY OF COMBUSTION<br />
EMISSION PARTICULATE MATTER TO<br />
ADSORB THE NEUTROPHIL-ATTRACTING<br />
CHEMOKINE IL-8. J. Seagrave and C. Knall.<br />
Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
#457 DIESEL EXHAUST PARTICLES SUPPRESS LPS-<br />
STIMULATED PRODUCTION OF PGE2 IN<br />
HUMAN ALVEOLAR MACROPHAGES: ROLE<br />
OF P38 MAPK AND ERK PATHWAYS. M. C.<br />
Madden 1 , S. Becker 1 and S. Mundandhara 2 . 1 ORD,<br />
NHEERL, HSD, Clinical Research Branch, U.S. EPA,<br />
Chapel Hill, NC and 2 CEMALB, University N.<br />
Carolina, Chapel Hill, NC.<br />
#458 SULFORAPHANE, A POTENT PHASE 2<br />
INDUCER, INHIBITS THE ADJUVANT EFFECT<br />
OF AEROSOLIZED DIESEL EXHAUST<br />
PARTICLES IN A MURINE MODEL FOR<br />
OVALBUMIN SENSITIZATION. M. J. Whitekus, S.<br />
A. Ritz and D. Diaz-Sanchez. UCLA School <strong>of</strong><br />
Medicine/Division <strong>of</strong> Clinical Immunology and Allergy,<br />
UCLA, Los Angeles, CA.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 81
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#459 THE INCREASE IN TOTAL IGE IN SERUM OF<br />
FEMALE MICE AFTER INTRANASAL<br />
EXPOSURE OF CARBON BLACK PARTICLES<br />
WITH POLLEN. K. Kobayashi 1 , K. Itoh 1 , Y. Inoue 1 ,<br />
Y. Kudo 1 , M. Tsunoda 1 , T. Satoh 1 , C. Yashiro 2 , Y.<br />
Sugita-Konishi 2 and Y. Aizawa 1 . 1 Preventive Medicine<br />
and Public Health, Kitasato University School <strong>of</strong><br />
Medicine, Sagamihara, Kanagawa, Japan and 2 Division<br />
<strong>of</strong> Microbiology, National Institute <strong>of</strong> Health Sciences,<br />
Setagaya-ku, Tokyo, Japan.<br />
#460 DIESEL AND HARDWOOD SMOKE EMISSIONS<br />
DIFFERENTIALLY AFFECT CLEARANCE AND<br />
INFLAMMATION OF INTRATRACHEALLY<br />
INSTILLED PSEUDOMONAS AERUGINOSA. M.<br />
Reed 1 and K. S. Harrod 2 . 1 <strong>Toxicology</strong>, Lovelace<br />
Respiratory Research Institute, Albuquerque, NM and<br />
2 Infectious Disease <strong>Program</strong>, Lovelace Respiratory<br />
Research Institute, Albuquerque, NM.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
#465 PHARMACOLOGY AND TOLERABILITY OF<br />
INS50589, A REVERSIBLE P2Y 12 RECEPTOR<br />
ANTAGONIST WITH ANTI-PLATELET<br />
AGGREGATION ACTIVITY, ADMINISTERED BY<br />
CONTINUOUS INTRAVENOUS INFUSION IN<br />
RATS AND DOGS. M. S. Cowlen, C. S. Crean, R.<br />
Krishnamoorthy, P. S. Watson, J. L. Boyer, W. M.<br />
Peterson and S. A. Anderson. Inspire, Durham, NC.<br />
#466 RANGE-FINDING TOXICITY STUDIES WITH<br />
SQ109, AN ANTI-TUBERCULAR AGENT, IN<br />
RATS AND DOGS. E. Glaze 1 , Y. Chen 2 , L. Alex 2 , R.<br />
Morrissey 3 , L. Jia 1 , P. Noker 4 and J. Tomaszewski 1 .<br />
1 2 NIH, Rockville, MD, University <strong>of</strong> Illinois, Chicago,<br />
IL, 3 Pathology Associates, Chicago, IL and 4 Southern<br />
Research Institute, Birmingham, AL.<br />
#467 SAFETY ASSESSMENT OF A NOVEL P38<br />
INHIBITOR IN CYNOMOLGUS MONKEYS<br />
FOLLOWING DAILY ORAL DOSING. S. L. Wild 1 ,<br />
T. Pabst Marra 1 , G. Jang 1 , W. Min 1 , R. House 3 , A.<br />
Mould 2 and M. Cosenza 1 . 1 Amgen Inc., Thousand Oaks,<br />
CA, 2 Covance Laboratories Inc., Madison, WI and<br />
3 DynPort Vaccine Company LLC, Frederick, MD.<br />
POSTER SESSION: PHARMACEUTICALS-GENERAL<br />
Chairperson(s): Mary Moslem, University <strong>of</strong> Texas, Galveston, TX.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#461 SAFETY EVALUATION OF AEROSOLIZED<br />
CYCLOSPORINE IN RATS AND DOGS. T. Wang 1 ,<br />
R. Steigerwalt 1 , M. Lynch 2 , R. Kovelesky 1 , C.<br />
Rodriguez 1 and K. Sprugel 1 . 1 Drug Assessment and<br />
Development, Chiron Corporation, Emeryville, CA and<br />
2 <strong>Toxicology</strong>, Battelle, Columbus, OH.<br />
#462 TOXICITY OF A SELECTIVE INHIBITOR OF<br />
LCK IS DUE TO INHIBITION OF LCK AND IS<br />
NOT CHEMOTYPE-RELATED. R. F. Stachlewitz 1 ,<br />
A. J. Schwartz 1 , B. Bettencourt 1 , J. Syed 1 , D. Conlon 1 ,<br />
J. E. Erickson 1 , E. O’Connor 1 , D. J. Calderwood 2 and<br />
G. C. Hirst 2 . 1 Discovery Safety, Metabolism &<br />
Pharmacokinetics, Abbott Bioresearch Center, Abbott<br />
Laboratories, Worcester, MA and 2 Chemistry, Abbott<br />
Bioresearch Center, Abbott Laboratories, Worcester,<br />
MA.<br />
#463 THE IMMUNOHISTOCHEMICAL EXPRESSION<br />
OF UROPLAKIN III IN RAT BLADDER TISSUE.<br />
S. Grainger. Covance Laboratories Ltd., Harrogate,<br />
United Kingdom. Sponsor: D. Everett.<br />
#464 BORTEZOMIB (VELCADE®) DOES NOT<br />
INDUCE THE FORMATION OF PROTEINASE K-<br />
RESISTANT PRION PROTEIN IN MURINE AND<br />
HUMAN NEURONAL CELL LINES IN VITRO. V.<br />
G. Sasseville 1 , A. Raczynski 1 , V. Csizmadia 1 , W.<br />
Riordan 1 , J. Ironside 2 , M. Rolfe 1 and P. Bouchard 1 .<br />
1 Millennium Pharmaceuticals, Inc., Cambridge, MA and<br />
2 University <strong>of</strong> Edinburgh, Edinburgh, United Kingdom.<br />
Sponsor: C. Alden.<br />
#468 CYTOFLAVINE REDUCES HYPOXIA CAUSED<br />
BY SEVERE ALCOHOLIC INTOXICATION AND<br />
MILD HEAD TRAUMA. A. D. Tsivinsky 1,3 , B. V.<br />
Batotsyrenov 2 , T. N. Savateeva 1 , V. E. Marusanov 3 and<br />
A. L. Kovalenko 1 . 1 Institute <strong>of</strong> <strong>Toxicology</strong>,<br />
St.Petersburg, Russian Federation, 2 Regional Poison<br />
Center, St.Petersburg, Russian Federation and<br />
3 Postgraduate Medical Academy, St.Petersburg, Russian<br />
Federation. Sponsor: J. Waksman.<br />
#469 TEMPO ATTENUATION OF DICLOFENAC<br />
ADDUCTION AND ENTEROPATHY. L. Kaphalia 1 ,<br />
J. F. Aronson 1 , K. A. Nethery 1 and M. Treinen<br />
Moslen 1,2 . 1 Pathology, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX and 2 Internal Medicine,<br />
University <strong>of</strong> Texas Medical Branch, Galveston, TX.<br />
#470 ENDOSCOPY STUDY OF THE<br />
GASTROINTESTINAL TOLERANCE OF<br />
STRONTIUM RANELATE IN CYNOMOLGUS<br />
MONKEYS. C. Fisch 1 , M. Attia 1 , F. Dargent 1 , S. de<br />
Jouffrey 1 , I. Dupin-Roger 2 and J. Claude 3 . 1 CIT,<br />
Evreux, France, 2 Laboratoires Servier, Courbevoie,<br />
France and 3 Paris V University, Paris, France.<br />
#471 TC 1734-112: PRECLINICAL SAFETY<br />
ASSESSMENT OF A SELECTIVE α4β2<br />
NICOTINIC ACETYLCHOLINE RECEPTOR<br />
AGONIST. V. M. Traina, G. J. Gatto and M. Bencherif.<br />
<strong>Toxicology</strong>, Targacept, Inc., Winston-Salem, NC.<br />
#472 OPIOIDS: OCCUPATIONAL CONTACT<br />
DERMATITIS AND THE LOCAL LYMPH NODE<br />
ASSAY (LLNA). M. J. Olson 1 , F. J. Guerriero 2 , M.<br />
Cunningham-Hill 2 and N. Tapscott 2 . 1 GlaxoSmithKline,<br />
Research Triangle Park, NC and 2 GlaxoSmithKline,<br />
Philadelphia, PA.<br />
82<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#473 USE OF NALTREXONE TO PREVENT ADVERSE<br />
EFFECTS OF SUFENTANIL IN BEAGLE DOGS.<br />
M. Soloviev 1 , M. J. Taylor 2 , T. R. Edwards 1 , J.<br />
Culwell 2 , C. R. Rampersand 2 , J. A. Felice 2 , D.<br />
Argonza 2 , M. Calimlin 2 , R. Ordonio 2 , R. Afan 2 , T. J.<br />
Siacotos 2 and G. J. Schaefer 1 . 1 WIL Research<br />
Laboratories, Ashland, OH and 2 Durect Corporation,<br />
Cupertino, CA.<br />
#474 FLORIDA RED TIDES: MOLECULAR<br />
THERAPEUTICS FROM A SEA OF RED. D.<br />
Baden 1 , A. J. Bourdelais 1 and W. Abraham 2 . 1 Center for<br />
Marine Science, UNCW, Wilmington, NC and 2 Division<br />
<strong>of</strong> Research, Mt Sinai Medical Center, Miami Beach,<br />
FL.<br />
#475 EFFICACY OF PIROXICAM IN ALLEVIATING<br />
TETRACYCLINE-INDUCED MUSCLE DAMAGE.<br />
J. Jahun 1 and H. M. Lantum 2 . 1 Faculty <strong>of</strong> Vet. Medicine,<br />
Amadou Bello University, Zaria, Nigeria and 2 African<br />
<strong>Society</strong> for Toxicological Sciences (ASTS), Rochester,<br />
NY.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SAFETY EVALUATION-EVALUATION OF<br />
METHODS IN VITRO/IN VIVO<br />
Chairperson(s): Albert Li, Advanced Pharmaceutical Sciences Inc.,<br />
Columbia, MD.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#476 THE EFFECTS OF CONTINUOUS<br />
INTRAVENOUS INFUSION OF SALINE ON<br />
BODY WEIGHT GAIN, FOOD INTAKE AND<br />
CLINICAL PATHOLOGY IN THE GÖTTINGEN<br />
MINI PIG. M. Mus and C. Copeman. IPN, CTBR Bio-<br />
Research Inc., Senneville, QC, Canada. Sponsor: M.<br />
Vezina.<br />
#477 BACKGROUND INCIDENCE OF<br />
EXPERIMENTAL DESIGN-RELATED EVENTS<br />
ON INTRAVENOUS INFUSION STUDIES. C.<br />
Copeman and M. Vezina. IPN, CTBR Bio-Research<br />
Inc., Senneville, QC, Canada.<br />
#478 VALIDATION OF A NEWLY INVENTED PORT<br />
CATHETER SYSTEM FOR CONTINUOUS<br />
INFUSION STUDIES. P. Nowak, S. Korte, F. Vogel<br />
and W. Mueller. Covance Laboratories GmbH, 48163<br />
Muenster, Germany. Sponsor: G. Weinbauer.<br />
#479 CONTINUOUS SUBCUTANEOUS INFUSION IN<br />
RODENTS AND NON RODENTS. M. Stilianesis, S.<br />
Groom and C. Copeman. <strong>Toxicology</strong>, CTBR,<br />
Senneville, QC, Canada. Sponsor: M. Vezina.<br />
#480 A METHOD FOR LONG-TERM CONTINUOUS<br />
SUBCUTANEOUS INFUSION IN RATS AND<br />
DOGS. G. Washer, S. Jerat, M. Landry, S. Vachon, N.<br />
Galliard, J. Laliberte, P. Ha and J. Hooson. ITR<br />
Laboratories Canada Inc., Baie d’Urfe, QC, Canada.<br />
#481 SUCCESSFULL PREVALIDATION OF AN IN<br />
VITRO RECONSTITUTED HUMAN CORNEA<br />
MODEL TO ASSESS THE EYE IRRITATING<br />
POTENTIAL OF CHEMICALS. B. De Wever 1 , F.<br />
Van Goethem 2 , F. Straube 3 , N. Alepee 4 and E.<br />
Adriaens 5 . 1 SkinEthic Laboratories, Nice, France,<br />
2 Johnson & Johnson Pharmaceutical R&D, Beerse,<br />
Belgium, 3 Novartis Pharmacology, Basel, Switzerland,<br />
4 5 Pfizer Global R&D, Amboise, France and University<br />
<strong>of</strong> Ghent, Ghent, Belgium.<br />
#482 IN VITRO SKIN IRRITATION : STRONG<br />
REPRODUCIBILITY FOR 50 CHEMICALS<br />
TESTED ON THE SKINETHIC<br />
RECONSTITUTED HUMAN EPIDERMAL<br />
MODEL. B. De Wever 1 , C. Tornier 1 , H. Maibach 2 , E.<br />
Adriaens 3 and M. Rosdy 1 . 1 SkinEthic Laboratories,<br />
Nice, France, 2 University Center <strong>of</strong> San Francisco, San<br />
Francisco, CA and 3 University <strong>of</strong> Ghent, Ghent,<br />
Belgium.<br />
#483 DETERMINATION OF THE DOSE-RESPONSE<br />
RELATIONSHIP FOR SURFACTANTS USING<br />
THE BCOP. S. Yan and E. Choudhury. Limited Brands,<br />
Paramus, NJ.<br />
#484 EVALUATION OF A SOLUBILITY PROTOCOL<br />
FOR IN VITRO CYTOTOXICITY TESTING. J.<br />
Strickland 1,2 , M. Paris 1,2 , W. Stokes 1 , S. Casati 3 , R.<br />
Tice 1,2 , H. Raabe 4 , C. Cao 5 , R. Clothier 6 , J. Harbell 4 , G.<br />
Mun 4 , A. Sizemore 4 , G. Moyer 4 , J. Madren-Whalley 4 ,<br />
C. Krishna 5 , M. Owen 6 , N. Borne 6 , M. Wenk 7 and M.<br />
Vallant 8 . 1 NICEATM, NIEHS, Research Triangle Park,<br />
NC, 2 ILS, Inc., Research Triangle Park, NC, 3 JRC,<br />
ECVAM, Ispra, Italy, 4 IIVS, Gaithersburg, MD, 5 ECBC,<br />
USArmy, Aberdeen Proving Ground, MD, 6 University<br />
<strong>of</strong> Nottingham, Nottingham, United Kingdom,<br />
7 8 BioReliance, Rockville, MD and NIEHS, Research<br />
Triangle Park, NC.<br />
#485 INTEGRATED DISCRETE MULTIPLE ORGAN<br />
CULTURE: A NOVEL IN VITRO<br />
EXPERIMENTAL SYSTEM FOR TOXICITY<br />
STUDIES. A. P. LI 1,3 , Y. Sakai 1 and C. Bode 2 .<br />
1 Advanced Pharmaceutical Sciences, Inc., Columbia,<br />
MD, 2 Tissue Transformation Technologies, Inc., Edison,<br />
NJ and 3 The ADMET Group LLC, Rockville, MD.<br />
#486 EFFECTS OF NANOSPHERES ON THE<br />
ADHESION AND CELL VIABILITY OF<br />
ASTROCYTES. C. Au 1 , L. Mutkus 2 , A. Dobson 2 , J.<br />
Riffle 3 , J. Lallli 3 , R. Claus 3 and M. Aschner 1 .<br />
1 Pediatrics, Vanderbilt University Medical Center,<br />
Nashville, TN, 2 Physiology and Pharmacology, Wake<br />
Forest University School <strong>of</strong> Medicine, Winston Salem,<br />
NC and 3 NanoSonic Inc., Blacksburg, VA.<br />
#487 IN VITRO MODEL OF PENETRATION AND<br />
ACTIVE DECONTAMINATION OF A<br />
CORROSIVE. L. MATHIEU 1 , C. Godard 1 , H.<br />
Coudouel 1 and A. H. Hall 2 . 1 Scientific Researches,<br />
Prevor, Talence, France and 2 Scientific communications,<br />
TCMTS Inc., Elk Mountain, WY.<br />
#488 TESTING CASCADE TO PREDICT THE<br />
POTENTIAL OF DRUG DISCOVERY<br />
COMPOUNDS TO INDUCE MITOCHONDRIAL<br />
DYSFUNCTION. L. D. Marroquin, G. J. Stevens and<br />
Y. Will. Safety Sciences, Pfizer, San Diego, CA.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 83
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#489 PREDICTION OF TOXICITY PARAMETERS OF<br />
AMINO- AND NITROBENZENE DERIVATIVES.<br />
K. Kabirov and A. Lyubimov. <strong>Toxicology</strong> Research<br />
Laboratory, University <strong>of</strong> Illinois at Chicago, Chicago,<br />
IL.<br />
#490 THE USE OF LASER SCANNING CYTOMETRY<br />
(LSC) AS A POTENTIAL TOOL FOR<br />
QUANTITATIVE ANALYSIS OF CYPS IN LIVER<br />
TISSUE SECTIONS. V. Kostrubsky 1 , S. Kulkarni 1 , A.<br />
Shen 2 , S. Schomaker 2 , I. Pruimboom-Brees 2 , D.<br />
Amacher 2 and D. Brees 2 . 1 WWSS, Pfizer, Ann Arbor,<br />
MI and 2 WWSS, Pfizer, Groton, CT.<br />
#491 METABONOMICS COMES INTO THE COLD:<br />
COMPARISON OF SENSITIVITY AND<br />
REPRODUCIBILITY OF CRYOGENIC PROBES<br />
VERSUS INCREASED FIELD STRENGTH. M. J.<br />
Santostefano 1 , B. C. Sweatman 2 , S. Castellino 3 , A. W.<br />
Nicholls 2 , S. A. Ringeissen 2 , B. F. Hamilton 1 , H. L.<br />
Jordan 1 , T. L. Schehl 4 and J. N. Haselden 2 . 1 SA,<br />
GlaxoSmithKline, Research Triangle Park, NC, 2 IPT,<br />
GlaxoSmithKline, Ware, United Kingdom, 3 DMPK,<br />
GlaxoSmithKline, Research Triangle Park, NC and<br />
4 Randstad, Research Triangle Park, NC.<br />
#492 EFFECTS OF REPEAT INTRAMUSCULAR<br />
DOSING OF KETAMINE FOR 14-DAYS IN<br />
CYNOMOLGUS MONKEYS. K. Moore 1 , J.<br />
Mandsager 1 , S. Roesch 1 , P. Franklin 1 , J. Jabbour 1 , W.<br />
Congdon 1 , S. Meyer 1 and R. Nagata 2,1 . 1 Safety<br />
Assessment, SNBL USA, Ltd.,, Everett, WA and 2 Shin<br />
Nippon Biomedical Laboratories, Ltd., Kagoshima,<br />
Japan.<br />
#493 A CANINE MODEL FOR SAFETY EVALUATION<br />
OF PERCUTANEOUS INTRAHEPATIC<br />
INJECTION OF 10% ROSE BENGAL. R. Jones 1 , E.<br />
Wachter 2 , D. Griffin1, K. Davis1 and N. Foster 1 .<br />
1 <strong>Toxicology</strong>, Charles River Laboratories– DDS–<br />
Arkansas Division, Redfield, AR and 2 Provectus<br />
Pharmaceuticals, Inc., Knoxville, TN.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: BIOMARKERS<br />
Chairperson(s): Timothy Fennell, RTI International, Research Triangle Park,<br />
NY and Deirdre Mahle, US Air Force, Wright-Patterson AFB, OH.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#494 CHARACTERIZATION OF NOVEL<br />
BIOMARKERS OF PERCHLORATE EXPOSURE<br />
IN ZEBRAFISH. S. Mukhi 1 and R. Patino 2 .<br />
1 Department <strong>of</strong> Environmental <strong>Toxicology</strong>, Texas Tech<br />
University, Lubbock, TX and 2 Texas Cooperative Fish<br />
and Wildlife Research Unit, Lubbock, TX.<br />
#495 CROSS-TISSUE BIOMARKERS THAT PREDICT<br />
AND CHARACTERIZE THE ACUTE PHASE<br />
RESPONSE. S. Tugendreich. Iconix Pharmaceuticals,<br />
Mountain View, CA. Sponsor: K. Kolaja.<br />
#496 THE CHANGE IN FINGER OVAL AREA IN A<br />
NON-HUMAN PRIMATE COLLAGEN-INDUCED<br />
ARTHRITIS MODEL AND ITS CORRELATION<br />
WITH BIOCHEMICAL PARAMETERS. N. Horai,<br />
H. Horai, H. Tsusaki, H. Tokado, K. Fukuzaki and R.<br />
Nagata. Shin Nippon Biomedical Laboratories, Ltd.,<br />
(SNBL), Kagoshima, Japan.<br />
#497 EFFECTS OF BRIEF ENVIRONMENTAL<br />
TOBACCO SMOKE (ETS) AND PROPIONIC<br />
ACID EXPOSURES. J. C. Walker, D. B. Walker, R.<br />
Whitt, J. C. Suarez, K. W. Winship, M. Russo and N. J.<br />
Walker. Sensory Research Institute, Florida State<br />
University, Tallahassee, FL. Sponsor: C. Smith.<br />
#498 RESPONSES OF MRP2-DEFICIENT TR RAT TO<br />
REPEATED DICLOFENAC EXPOSURE. V.<br />
Ramirez-Alcantara 1,2 , L. Kaphalia 1 , J. F. Aronson 1,3 , M.<br />
F. Kanz 1 and M. Treinen-Moslen 1,3 . 1 Pathology, UTMB,<br />
Galveston, TX, 2 CINVESTAV-IPN, D.F, Mexico and<br />
3 Internal Medicine, UTMB, Galveston, TX.<br />
#499 EVALUATION OF THE EFFECTS OF<br />
INTRANASAL ADMINISTRATION OF IL-4 TO<br />
MICE AND INHIBITION OF THESE EFFECTS<br />
BY A MURINE IL-4 RECEPTOR ANTIBODY. M.<br />
Horner 1 , L. L. Carlock 1 , J. Tocker 1 , B. He 2 and J. L.<br />
Bussiere 1 . 1 Amgen Inc., Thousand Oaks, CA and 2 Gene<br />
Logic Laboratories Inc., Gaithersburg, MD.<br />
#500 CYSTEINYL KERATIN 1 AND 10 PROTEIN<br />
ADDUCTS OF BENZENE OXIDE AND<br />
NAPHTHALENE-1, 2-OXIDE FOR<br />
QUANTIFICATION OF DERMAL EXPOSURE TO<br />
BENZENE AND NAPHTHALENE. L. A. Nylander-<br />
French 1 , D. Fox 1 , K. Jayara 1 , D. G. Klapper 2 , A. Gold 1 ,<br />
L. M. Ball 1 and J. E. French 3 . 1 Environmental Sciences<br />
& Engineering, UNC-CH, Chapel Hill, NC,<br />
2 Department <strong>of</strong> Microbiology and Immunology, UNC-<br />
CH, Chapel Hill, NC and 3 Laboratory <strong>of</strong> Molecular<br />
<strong>Toxicology</strong>, NIEHS, Research Triangle Park, NC.<br />
#501 GLYCOPROTEOMIC ANALYSIS OF RAT<br />
PLASMA FOLLOWING PROTEIN<br />
PHOSPHATASE INHIBITION BY<br />
MICROCYSTIN-LR. C. R. Wilson 1,3 , F. E. Regnier 2<br />
and S. B. Hooser 1,3 . 1 Animal Disease Diagnostic<br />
Laboratory, Purdue University, West Lafayette, IN,<br />
2 Chemistry, Purdue University, West Lafayette, IN and<br />
3 Vet. Path, Purdue University, West Lafayette, IN.<br />
#502 FORMATION OF UVA LIGHT INDUCED<br />
OXYPEUCEDANIN DNA ADDUCTS AND<br />
DETECTION USING HPLC 32 P-<br />
POSTLABELING. L. H. Couch 1,2 , N. V. Gopee 1,2 , M.<br />
I. Churchwell 1 , D. R. Doerge 1 , W. G. Wamer 3 and P. C.<br />
Howard 1,2 . 1 Division <strong>of</strong> Biochemical <strong>Toxicology</strong>,<br />
NCTR, U.S. FDA, Jefferson, AR, 2 NTP Center for<br />
Phototoxicology, NCTR, U.S. FDA, Jefferson, AR and<br />
3 Office <strong>of</strong> Cosmetics and Colors, CFSAN, U.S. FDA,<br />
College Park, MD.<br />
84<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#503 ACTIVATION OF HUMAN AH RECEPTOR<br />
SIGNALING BY POLYCYCLIC AROMATIC<br />
HYDROCARBONS AND EXTRACTS OF SOILS<br />
FROM THE NEW ORLEANS AREA. C. A. Miller 1 ,<br />
G. Wang 2 , J. Hughes 3 and A. Alnafisi 1 . 1 Environmental<br />
Health Sciences, Tulane University, New Orleans, LA,<br />
2 Chemistry, Xavier University, New Orleans, LA and<br />
3 Biostatistics, Tulane University, New Orleans, LA.<br />
#504 INDUCTION OF CYCLOOXYGENASE-2 IN THE<br />
LUNGS OF RATS EXPOSED TO TOBACCO<br />
SMOKE. K. R. Smith 1 , S. T. Owens 1 , A. W. Goodyear 1 ,<br />
U. P. Kodavanti 2 and K. E. Pinkerton 1 . 1 Center for<br />
Health and the Environment, University <strong>of</strong> California,<br />
Davis, CA and 2 NHEERL, U.S. EPA, Research Triangle<br />
Park, NC.<br />
#505 DNA AND HEMOGLOBIN ADDUCTS FROM<br />
ORAL ADMINISTRATION OF ACRYLAMIDE TO<br />
MALE FISCHER 344 RATS. T. Fennell 1 , R. W.<br />
Snyder 1 and M. A. Friedman 2 . 1 RTI International,<br />
Research Triangle Park, NC and 2 UMDNJ, Newark, NJ.<br />
#506 CHARACTERIZATION OF MAINSTREAM<br />
CIGARETTE SMOKE-INDUCED CHRONIC<br />
INFLAMMATION IN ICR AND C57BL/6 MICE. K.<br />
C. Hodge-Bell 1 , K. M. Lee 2 , A. F. Fuciarelli 2 , R. A.<br />
Renne 2 , S. J. Harbo 2 and W. J. McKinney 1 . 1 Research &<br />
Technology, Phillip Morris USA, Richmond, VA and<br />
2 Battelle <strong>Toxicology</strong> Northwest, Richland, WA.<br />
#507 NANBIOTECHNOLOGY: AUTOMATED REAL-<br />
TIME MEASURES OF TOXICANT INFLUENCE<br />
ON CELL SPEED IN CHEMOTACTIC<br />
ENVIRONMENTS. X. Yin, N. Hadjout, D. Knecht and<br />
M. A. Lynes. Molecular and Cell Biology, University <strong>of</strong><br />
Connecticut, Storrs, CT, CT.<br />
#508 MODULATION OF EXTRACELLULAR MATRIX<br />
MARKS EARLY DEGENERATION OF KIDNEY<br />
PAPILLAE INTERSTITIAL CELLS (IC) OF RATS<br />
DOSED WITH INDOMETHACIN (IND). P.<br />
Ciaccio 1 , S. Emeigh Hart 1 , J. Bartock 1 , V. Oreffo 2 , C.<br />
Kind 2 , K. Kenne 3 , S. Matis 1 , F. Pognan 4 and B.<br />
Graham 4 . 1 Safety Assessment, Astrazeneca<br />
Pharmacology, Wilmington, DE, 2 Astrazeneca<br />
Pharmacology, Leicestershire, United Kingdom,<br />
3 Astrazeneca Pharmacology, Sodertalje, Sweden and<br />
4 Astrazeneca Pharmacology, Macclesfield, United<br />
Kingdom.<br />
#509 A METABONOMICS INVESTIGATION OF THE<br />
HEPTOTOXICITY OF VALPROIC ACID. L. K.<br />
Schnackenberg 1 , D. Hansen 2 and R. D. Beger 1 .<br />
1 Division <strong>of</strong> Systems <strong>Toxicology</strong>, National Center for<br />
Toxicological Research, Jefferson, AR and 2 Division <strong>of</strong><br />
Genetic and Reproductive <strong>Toxicology</strong>, National Center<br />
for Toxicological Research, Jefferson, AR.<br />
#510 POTENTIAL ROLE OF METHYLGUANIDINE<br />
FOUND IN METABONOMICS INVESTIGATION<br />
OF NEPHROTOXICITY. A. Amberg 1 , I.<br />
Stammberger 1 , M. Kurz 2 , M. Will 2 , H. Juretschke 3 and<br />
M. Gerl 3 . 1 Drug Safety Evaluation, San<strong>of</strong>i Aventis,<br />
Hattersheim, Germany, 2 Chemistry, San<strong>of</strong>i Aventis,<br />
Frankfurt, Germany and 3 Gobal Experimental Medicine,<br />
San<strong>of</strong>i Aventis, Frankfurt, Germany. Sponsor: M.<br />
Bonnefoi.<br />
#511 PATTERN RECOGNITION OF NMR SPECTRA<br />
OF URINE FROM WISTAR RATS DOSED WITH<br />
LIVER AND RENAL TOXICANTS. R. D. Beger 1 , L.<br />
K. Schnackenberg 1 , Y. P. Dragan 1 , M. D. Reily 2 and D.<br />
G. Robertson 3 . 1 Division <strong>of</strong> Systems <strong>Toxicology</strong>,<br />
National Center for Toxicological Research, Jefferson,<br />
AR, 2 Discovery Technologies, Pfizer, Ann Arbor, MI<br />
and 3 World Wide Safety Sciences, Pfizer, Ann Arbor,<br />
MI.<br />
#512 DIBUTYLTIN EXPOSURE ALTERS<br />
CIRCULATING BLOOD GROWTH FACTOR<br />
LEVELS. T. Lyons-Darden 1 , S. Jenkins 2 , R. Luebke 4<br />
and S. Barone 3 . 1 Neurotoxicology, U.S. EPA, Research<br />
Triangle Park, NC, 2 Office <strong>of</strong> Air Quality Planning and<br />
Standards, U.S. EPA, Research Triangle Park, NC,<br />
3 National Center for Environmental Assessment, U.S.<br />
EPA, Washington, DC and 4 Environmantal <strong>Toxicology</strong>,<br />
U.S. EPA, Research TRaingle Park, NC.<br />
#513 EVALUATION OF CYTOCHROME P450 1A1 AND<br />
1B1 IN HUMAN BLOOD LYMPHOCYTES AS<br />
BIOMARKERS OF EXPOSURE TO DIOXIN-LIKE<br />
COMPOUNDS. M. van Duursen, T. Sanderson and M.<br />
van den Berg. Institute for Risk Assessment Sciences,<br />
Utrecht, Netherlands.<br />
#514 MULTI-TISSUE CHARACTERIZATION OF<br />
RHABDOMYOLYSIS FOR THE HIGH PROFILE<br />
FAILURE CERIVASTATIN. B. Ganter and K. L.<br />
Kolaja. Chemogenomics and <strong>Toxicology</strong>, Iconix<br />
Pharmaceuticals, Mountain View, CA.<br />
#515 EVALUATION OF KIDNEY TOXICITY<br />
DETECTION METHODS: URINARY GSTS AND<br />
PROTEIN PROFILING BY SELDI-TOF-MS. K.<br />
Okamoto 1,2 , W. W. Collette 2 , M. Mondal 2 , A. de<br />
Peyster 1 and G. J. Stevens 2 . 1 Graduate School <strong>of</strong> Public<br />
Health, San Diego State University, San Diego, CA and<br />
2 Worldwide Safety Sciences, Pfizer Global Research<br />
and Development, San Diego, CA.<br />
#516 CHARACTERIZATION OF EPOXIDE ADDUCTS<br />
OF POLYCYCLIC AROMATIC<br />
HYDROCARBONS (PAH) WITH HEMOGLOBIN<br />
(HB). M. Y. Ali, H. E. Hurst and S. R. Myers.<br />
Pharmacology and <strong>Toxicology</strong>, Center for<br />
Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#517 EXHALATION OF CYTOKINES BY<br />
LABORATORY RODENTS. E. Bermudez and O. R.<br />
Moss. CIIT Centers for Health Research, Research<br />
Triangle Park, NC.<br />
#518 THE INFLUENCE OF DIET ON ENDPOINTS<br />
TYPICALLY USED IN 13-WEEK TOXICITY<br />
STUDIES FOR RODENTS. E. Harvey 2 , L. J. Betz 2<br />
and G. Travlos 1 . 1 NIEHS, Durham, NC and 2 Constella<br />
Health Sciences, Durham, NC. Sponsor: C. Portier.<br />
MONDAY<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#519 USE OF IN VITRO TECHNOLOGIES AND<br />
METABONOMICS IN THE STUDY OF<br />
PHOSPHOLIPIDOSIS. C. E. Thomas 1 , J. M. Colet 2 ,<br />
A. Meissner 2 , B. Halstead 1 , R. Morgan 1 , K. Kramer 2 ,<br />
W. Dewe 3 and D. Monteith 1 . 1 Inv. <strong>Toxicology</strong>., Lilly<br />
Research Labs, Greenfield, IN, 2 Inv. <strong>Toxicology</strong>., Lilly<br />
Development Centre, Mont-Saint-Guibert, Belgium and<br />
3 Statistics, Lilly Development Centre, Mont-Saint-<br />
Guibert, Belgium.<br />
#520 EVALUATION OF VITAMIN K AND VITAMIN K<br />
EPOXIDE AS BIOMARKERS OF<br />
COAGULOPATHY IN RAT SERUM UTILIZING<br />
HPLC. K. A. Navetta, P. E. Quintas, M. D. Aleo and J.<br />
L. Colangelo. Safety Sciences, Pfizer, Groton, CT.<br />
#521 A MOLECULAR BASIS FOR THE PREDICTION<br />
OF RENAL TUBULAR INJURY BY DRUG<br />
SIGNATURES FOLLOWING SHORT-TERM<br />
COMPOUND TREATMENT. M. Fielden, G.<br />
Natsoulis and K. Kolaja. Chemogenomics and<br />
<strong>Toxicology</strong>, Iconix Pharmaceuticals Inc., Mountain<br />
View, CA.<br />
#522 BIOMARKERS THAT CHARACTERIZE<br />
FIBROSIS AND BILE DUCT HYPERPLASIA. A.<br />
Vladimirova, R. Brennan, M. Fielden, K. Kolaja and C.<br />
Pearson. Iconix Pharmaceuticals, Inc., Mountain View,<br />
CA.<br />
#523 MULTI-ADDUCT ANALYSIS OF GLOBIN FROM<br />
MICE AND RATS AFTER INHALATION<br />
EXPOSURE TO 1, 3-BUTADIENE. N. I. Georgieva 1 ,<br />
G. Boysen 1 , P. B. Upton 1 , Y. Li 1 , V. Walker 2 and J. A.<br />
Swenberg 1 . 1 ESE, UNC, Chapel Hill, NC and 2 Lovelace<br />
Respiratory Research Institute, Albuquerque, NM.<br />
#524 INTERACTIONS OF COMPLEX CHEMICAL<br />
MIXTURES FROM CONTAMINATED<br />
SEDIMENTS AT A SUPERFUND SITE. A.<br />
Gillespie 1 , T. D. Phillips 1 , T. J. McDonald 2 , L. He 1 , G.<br />
Zhou 2,1 and K. Donnelly 2,1 . 1 VIBS, Texas A&M<br />
University, College Station, TX and 2 EOH, Texas A&M<br />
University H.S.C., S.R.P.H., College Station, TX.<br />
#525 CORRELATION OF HEXENAL-DERIVED DNA<br />
BINDING WITH DETOXIFICATION AND DNA<br />
REPAIR STATUS IN CULTURED CELLS. M. D.<br />
Stout 1 , J. Nakamura 2 , G. Boysen 2 , M. W. Powley 2 and J.<br />
A. Swenberg 1,2 . 1 Curriculum in <strong>Toxicology</strong>, University<br />
<strong>of</strong> North Carolina, Chapel Hill, NC and 2 Environmental<br />
Sciences and Engineering, University <strong>of</strong> North Carolina,<br />
Chapel Hill, NC.<br />
#526 COMPARISON OF PLASMA AND URINE<br />
SAMPLES FROM ANIT-EXPOSED F344 RATS<br />
USING NMR SPECTROSCOPY. D. Mahle 1 , N. J.<br />
DelRaso 1 , S. C. Gustafson 2 , C. L. Leakeas 2 , M. P.<br />
Westrick 1 , A. E. Neuforth 3 and N. V. Reo 3 .<br />
1 AFRL/HEPB, US Air Force, Wright-Patterson AFB,<br />
OH, 2 AFIT/ENG, US Air Force, Wright-Patterson AFB,<br />
OH and 3 Wright State University, Fairborn, OH.<br />
#527 USE OF METABOLOMICS TO IDENTIFY<br />
BIOMARKERS OF BREVETOXIN EXPOSURE. A.<br />
J. bourdelais 1 , J. Benson 2 , A. Higgins 3 , H. Mei 3 , K.<br />
Powell 3 , K. Wang 3 , B. Tibbetts 2 and D. G. Baden 1 .<br />
1 2 CMS, UNCW, Wilmington, NC, Lovelace Respiratory<br />
Research Institute, Albuquerque, NM and 3 Icoria,<br />
Research Triangle Park, NC.<br />
#528 CAN LEVELS OF PLASMA TESTOSTERONE BE<br />
USED TO PREDICT MALE SEXUAL MATURITY<br />
IN RHESUS MONKEYS (MACACA MULATTA)?<br />
M. D. Saunders, R. Davis, S. Fox and L. Earl.<br />
<strong>Toxicology</strong> Operations, Huntingdon Life Sciences,<br />
Huntingdon, United Kingdom. Sponsor: C. Hardy.<br />
#529 ADMINISTRATION OF A MEK INHIBITOR<br />
RESULTS IN TISSUE MINERALIZATION IN THE<br />
RAT DUE TO DYSREGULATION OF<br />
PHOSPHORUS AND CALCIUM HOMEOSTASIS.<br />
A. P. Brown, C. Courtney, T. Carlson and M. Graziano.<br />
Safety Sciences, Pfizer Global Research and<br />
Development, Ann Arbor, MI.<br />
#530 USE OF METABONOMIC ANALYSIS FOR<br />
BIOMARKERS OF MUSCULOSKELETAL<br />
SYNDROME IN RATS. F. Grzemski 1 , L. C. Robosky 2 ,<br />
M. D. Reily 2 , D. Baker 2 , C. A. Lesch 3 , M. G. Evans 1 ,<br />
D. F. Wells 1 and D. G. Robertson 3 . 1 Safety Sciences,<br />
Pfizer, Ann Arbor, MI, 2 Discovery Technology, Pfizer,<br />
Ann Arbor, MI and 3 Inflammation Pharmacology,<br />
Pfizer, Ann Arbor, MI.<br />
#531 INVESTIGATION OF A HEPATOTOXICITY<br />
SCREENING SYSTEM IN PRIMARY CELL<br />
CULTURE. R. Kikkawa, T. Yamamoto, T. Fukushima,<br />
Y. Hamada, H. Yamada and I. Horii. PGRD Nagoya<br />
Lab., Pfizer Japan Inc., Taketoyo, Aichi, Japan.<br />
Sponsor: K. Masaaki.<br />
#532 THE IDENTIFICATION OF POTENTIAL<br />
VASCULITIS BIOMARKERS TARGETED<br />
THROUGH SELDI SCREENING. C. Drupa 1 , J. L.<br />
Colangelo 1 , R. A. Goldstein 1 , M. L. Mirsky 1 , R. M.<br />
Leimgruber 2 , M. Cabonce 2 , P. W. Brown 2 and E.<br />
Dalmasso 3 . 1 World Wide Safety Sciences, Pfizer,<br />
Groton, CT, 2 World Wide Safety Sciences, Pfizer, St.<br />
Louis, MO and 3 Ciphergen Biosystems, Inc., Fremont,<br />
CA. Sponsor: M. Lawton.<br />
#533 ALANINE AMINOTRANSFERASE ACTIVITY IN<br />
THE FA2N-4 HEPATOCYTE CLONE. E. R. Jackson<br />
and D. E. Amacher. Safety Sciences, Pfizer, Inc.,<br />
Groton, CT.<br />
#534 TOXICOLOGIC AND PATHOLOGIC<br />
SURVEILLANCE OF SEARCH & RESCUE DOGS<br />
DEPLOYED TO THE WORLD TRADE CENTER,<br />
THE PENTAGON, AND THE STATEN ISLAND<br />
FRESH KILLS LANDFILL SITES. W. K. Rumbeiha 1 ,<br />
S. D. Fitzgerald 1 , E. W. Braselton 1 , C. M. Otto 2 and A.<br />
B. Downend 2 . 1 Pathobiology and Diagnostic<br />
Investigagtion, Michigan State University, Lansing, MI<br />
and 2 Clinical Sciences, School <strong>of</strong> Veterinary Medicine,<br />
University <strong>of</strong> Pennsyllvania, Philadelphia, PA.<br />
#535 SEQUENCE AND EXPRESSION ANALYSIS OF<br />
CANINE ALT1 AND ALT2. L. Nelms, B. Lu and M.<br />
Lawton. Pfizer, Groton, CT.<br />
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and ToxExpo<br />
<strong>Program</strong> Description<br />
#536 AUTOMATED BIOCHEMICAL<br />
MEASUREMENTS OF ACYL-COA OXIDASE<br />
AND CARNITINE PALMITOYLTRANSFERASE<br />
FOR ASSESSMENT OF PPAR-INDUCED<br />
PEROXISOME PROLIFERATION IN<br />
CYNOMOLGUS MONKEYS. D. F. Adams, M. A.<br />
Tirmenstein, K. M. Lynch, C. X. Hu, B. E. Maleeff, T.<br />
L. Gales, T. S. Sellers, D. Ennulat and L. W. Schwartz.<br />
Safety Asssessment, GlaxoSmithKline, King <strong>of</strong> Prussia,<br />
PA.<br />
#537 EVALUATING TOXICOLOGY AT A SYSTEMS<br />
LEVEL USING COHERENT ANALYSIS OF<br />
LARGE-SCALE DATA STREAMS. I. Shah, Z. Cai,<br />
B. Bullard, T. Colatsky, A. Berger, M. Fedor, P. Hurban,<br />
G. Yuan and A. Higgins. Icoria, INC, Research Triangle<br />
Park, NC. Sponsor: N. Sponsor.<br />
#538 A COMPARISON OF THE SPECIFICITY AND<br />
SENSITIVITY OF TRADITIONAL BIOMARKERS<br />
OF NEPHROTOXICITY IN THE RAT WITH<br />
METABONOMIC AND PROTEOMIC<br />
METHODOLOGIES. A. C. Gibbs. Scientific and<br />
Regulatory Consulting, Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom. Sponsor: D. Everett.<br />
#539 THE RELATIONSHIP OF TREATMENT-<br />
RELATED DECREASES IN SERUM ALKALINE<br />
PHOSPHATASE ACTIVITY WITH<br />
ALTERATIONS IN BODY WEIGHT FOR RATS IN<br />
13-WEEK TOXICITY STUDIES. L. Betz 2 , E.<br />
Harvey 2 and G. Travlos 1 . 1 NIEHS, Durham, NC and<br />
2 Constella Health Sciences, Durham, NC. Sponsor: C.<br />
Portier.<br />
#540 IDENTIFYING CANDIDATE BIOMARKERS OF<br />
VITAMIN D ANALOG–INDUCED RENAL<br />
MINERALIZATION USING A SYSTEMS<br />
BIOLOGY APPROACH. C. I. Nduaka 1 , L. Jones 2 , M.<br />
Boren 1 , N. hanson 1 , T. Osborne 3 , K. Herbert 1 , L.<br />
Nelms 1 , M. Nowakowski 1 , K. Steever 1 , C. Edmond 1 , D.<br />
Blackwell 1 , M. Delnomdedieu 1 , C. Bagi 1 , F. Geoly 1 and<br />
M. Lawton 1 . 1 World Wide Safety Sciences, Pfizer Inc.,<br />
Groton, CT, 2 University <strong>of</strong> Maryland, Baltimore, MD<br />
and 3 University <strong>of</strong> Illinois, Chicago, IL.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: MALE REPRODUCTIVE<br />
Chairperson(s): Sandra Morseth, Morseth Consulting LLC, Jefferson, MD<br />
and Darryl Arfsten, US Navy, Wright-Patterson AFB, OH.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#541 EFFECT OF TESTICULAR EDEMA ON<br />
SPERMATOGENESIS IN TOXICANT-TREATED<br />
RAT TESTES. K. Porter, C. C. Weng and M. L.<br />
Meistrich. Experimental Radiation Oncology, U.T. M.D.<br />
Anderson Cancer Center, Houston, TX.<br />
#542 EFFECT OF ETHYLENE GLYCOL<br />
MONOETHYL ETHER ON SPERM MOTION IN<br />
RAT. R. WANG 1 , K. OHTANI 1 , N. JIA 2 , M. SUDA 1 ,<br />
X. GAO 2 and T. HONMA 1 . 1 National Institute Ind.<br />
Health, Kawasaki, Kanagawa, Japan and 2 Beijing<br />
Diseases Control and Prevention Center, Beijing, China.<br />
Sponsor: X. YU.<br />
#543 CHANGES OF GENE EXPRESSION IN THE<br />
EPIDIDYMIDES AND SPERM ACROSOME<br />
REACTION IN RATS TREATED WITH<br />
SULFASALAZINE FOR SEVERAL DAYS. Y.<br />
Hamada 1 , T. Fukushima 1,2 , M. Komiyama 2 , C. Mori 2<br />
and I. Horii 1 . 1 Worldwide Safety Sciences, Pfizer<br />
Global and Research Nagoya Laboratories, Taketoyo,<br />
Aichi, Japan and 2 Bioenvironmental Medicine, Chiba<br />
University, Chiba, Japan. Sponsor: M. Kurata.<br />
#544 DEVELOPMENTAL TOXICOLOGY OF CJC-1131,<br />
A LONG-ACTING GLP-1 ANALOGUE. B.<br />
Lawrence 1 , S. Wen 1 , Y. Fukushima 1 , E. M. Lewis 2 , S.<br />
Morseth 3 and J. Castaigne 1 . 1 ConjuChem, Inc.,<br />
Montreal, QC, Canada, 2 Argus Research, Horsham, PA<br />
and 3 Morseth Consulting LLC., Jefferson, MD.<br />
#545 EFFECT OF IMPLANTED DEPLETED URANIUM<br />
(DU) ON MALE RAT REPRODUCTIVE<br />
SUCCESS, SPERM CONCENTRATION AND<br />
MOTION. D. P. Arfsten 1 , E. R. Wilfong 1 , E. W.<br />
Johnson 1 , D. J. Schaeffer 2 and K. R. Still 1 . 1 NHRC EHE<br />
Lab., Wright-Patterson AFB, OH and 2 Department <strong>of</strong><br />
Veterinary Biosciences, University <strong>of</strong> Illinois at Urbana<br />
Champaign, Urbana, IL.<br />
#546 THE EFFECTS OF SUBACUTE ORAL<br />
EXPOSURE TO VINCLOZOLIN ON<br />
REPRODUCTIVE PARAMETERS IN<br />
PERIPUBERTAL AND POST-PUBERTAL BOARS.<br />
T. J. Evans 1 , E. M. Walters 1 , Y. Agca 1 , T. J. Fangman 2 ,<br />
F. Williams III 1 , J. K. Critser 1 and R. A. Hess 3 .<br />
1 Veterinary Pathobiology, University <strong>of</strong> Missouri,<br />
Columbia, MO, 2 Veterinary Extension and Continuing<br />
Education, University <strong>of</strong> Missouri, Columbia, MO and<br />
3 Veterinary Biosciences, University <strong>of</strong> Illinois, Urbana,<br />
IL.<br />
#547 DELAYED PREPUTIAL SEPARATION (PPS) AND<br />
SP22 MEASUREMENT IN RATS ADMINISTERED<br />
BROMOCHLOROACETIC ACID (BCA) IN<br />
DRINKING WATER. C. S. Sloan 1 , G. R. Klinefelter 2 ,<br />
J. M. Goldman 2 , K. D. Vick 1 , P. A. Fail 1 and R. W. Tyl 1 .<br />
1 Life Sciences and <strong>Toxicology</strong>, RTI International,<br />
Research Triangle Park, NC and 2 Reproductive<br />
<strong>Toxicology</strong> Division, NHEERL, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#548 USE OF 5α-DIHYDROTESTOSTERONE (DHT)-<br />
EXPOSED UROGENITAL SINUSES (UGS) FROM<br />
FEMALE MICE TO INVESTIGATE INHIBITION<br />
OF PROSTATIC BUDDING CAUSED BY 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN (TCDD). T.<br />
Lin and R. E. Peterson. School <strong>of</strong> Pharmacy, University<br />
<strong>of</strong> Wisconsin, Madison, WI.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 87
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#549 IN VIVO EXPOSURE OF PREPUBERTAL RATS<br />
TO METHOXYCHLOR (M) INHIBITS EX VIVO<br />
LEYDIG CELL (LC) BASAL AND HUMAN<br />
CHORIONIC GONADOTROPIN (HCG)-<br />
STIMULATED TESTOSTERONE (T)<br />
FORMATION. E. P. Murono and R. C. Derk.<br />
Pathology and Physiology Research Branch,<br />
CDC/NIOSH, Morgantown, WV. Sponsor: V.<br />
Castranova.<br />
#550 IN UTERO EXPOSURE TO 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN ALTERS<br />
SONIC HEDGEHOG AND BONE<br />
MORPHOGENIC PROTEIN 4 EXPRESSION IN<br />
THE DEVELOPING MOUSE UROGENITAL<br />
SINUS. W. A. Fritz, W. A. Bushman and R. E. Peterson.<br />
University <strong>of</strong> Wisconsin, Madison, WI.<br />
#551 CRITICAL WINDOW OF MALE<br />
REPRODUCTIVE TRACT DEVELOPMENT IN<br />
RATS FOLLOWING GESTATIONAL EXPOSURE<br />
TO DI-N-BUTYL PHTHALATE. C. M. Carruthers 1<br />
and P. Foster 2 . 1 NIEHS, Research Triangle Park, NC<br />
and 2 NIEHS, Research Triangle Park, NC.<br />
#552 EFFECT OF DI(N-BUTYL) PHTHALATE ON<br />
MALE REPRODUCTIVE ORGAN<br />
DEVELOPMENT IN HYPOTHYROID RATS. H.<br />
Kim, E. Lee, M. Ahn and H. Kim. College <strong>of</strong> Pharmacy,<br />
Pusan National University, PUSAN, South Korea.<br />
Sponsor: I. Yu.<br />
#553 EFFECTS OF TCDD ON STEROIDOGENESIS OF<br />
RAT LEYDIG CELLS. K. P. Lai, H. Y. Yeung, M. H.<br />
Wong and C. K. Wong. Biology, Hong Kong Baptist<br />
University, Hong Kong, China.<br />
#554 ESTROGEN RECEPTOR ALPHA IS NOT<br />
REQUIRED FOR NORMAL PROSTATIC BUD<br />
FORMATION OR FOR INHIBITION OF<br />
PROSTATIC BUD FORMATION BY 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN (TCDD) IN<br />
MICE. S. M. Hicks 2 , T. Lin 1 , M. Mukai 3 , P. S. Cooke 3<br />
and R. E. Peterson 1,2 . 1 School <strong>of</strong> Pharmacy, University<br />
<strong>of</strong> Wisconsin, Madison, WI, 2 Molecular and<br />
Environmental <strong>Toxicology</strong> Center, University <strong>of</strong><br />
Wisconsin, Madison, WI and 3 Department <strong>of</strong> Veterinary<br />
Biosciences, University <strong>of</strong> Illinois, Urbana, IL.<br />
#555 CHARACTERIZATION OF 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN (TCDD)<br />
RESPONSIVENESS IN MOUSE UROGENITAL<br />
SINUS (UGS) USING ARYL HYDROCARBON<br />
RECEPTOR (AHR)-DEPENDENT LACZ MICE. D.<br />
R. Kelman 1 , J. C. Bemis 3 , T. Lin 2 , T. A. Gasiewicz 3 and<br />
R. E. Peterson 1,2 . 1 Molecular and Environmental<br />
<strong>Toxicology</strong> Center, University <strong>of</strong> Wisconsin, Madison,<br />
WI, 2 Pharmacy, University <strong>of</strong> Wisconsin, Madison, WI<br />
and 3 Environmental Medicine, University <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#556 ANALYSIS OF CORTACTIN EXPRESSION IN<br />
THE ECTOPLASMIC SPECIALIZATION OF<br />
TESTES IN FLUTAMIDE TREATMENT MOUSE.<br />
R. Anahara 1 , Y. Toyama 2 , M. Maekawa 2 , M. Kai 3,4 , F.<br />
Ishino 5 , K. Toshimori 2 and C. Mori 1,6 .<br />
1 Bioenvironmental Medicine, Chiba University, Chiba,<br />
Japan, 2 Anatomy and Developmental Biology, Chiba<br />
University, Chiba, Japan, 3 Pharmaceutical Research<br />
Laboratories, Kirin Brewery Co. Ltd., Gunma, Japan,<br />
4 Division for Gene Research, Center for Biological<br />
Resources and Informatics, Tokyo, Japan, 5 Medical<br />
Research Institute, Tokyo Medical and Dental<br />
University, Tokyo, Japan and 6 CREST, Japan Science<br />
and Technology Agency, Kawaguchi, Japan.<br />
#557 CHARACTERIZATION OF THE GENE<br />
EXPRESSION PROFILE INDUCED BY<br />
ETHYLENE GLYCOL MONOMETHYL ETHER<br />
IN THE RAT TESTIS WITH DNA<br />
MICROARRAYS. E. Blomme 1 , R. Ciurlionis 1 , K.<br />
Whitney 1 , I. Milicic 1 , M. Strakhova 1 and J. Waring 1 .<br />
1 2 Abbott Labs, Abbott Park, IL and Abbott Labs, Abbott<br />
Park, IL.<br />
#558 THE USE OF CD-1 MICE FOR FERTILITY AND<br />
EARLY-EMBRYONIC DEVELOPMENT (ICH-1<br />
STUDIES. L. Pinsonneault, A. St-Pierre, C. Tremblay,<br />
M. Adamo, L. Pouliot and K. Robinson. Reproductive<br />
<strong>Toxicology</strong>, CTBR Bio-Research Inc., Senneville, QC,<br />
Canada. Sponsor: M. Vezina.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: GENE EXPRESSION II<br />
Chairperson(s): Curtis Klaassen, Kansas University Medical Center, Kansas<br />
City, KS.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#559 UNDERSTANDING HEPATIC VACUOLATION:<br />
GENE EXPRESSION ANALYSIS OF<br />
PHOSPHOLIPIDOSIS AND STEATOSIS IN RAT<br />
LIVER. D. Pelletier, B. Lu and M. Lawton. Molecular<br />
and Investigative <strong>Toxicology</strong>, Pfizer Inc., Groton, CT.<br />
#560 TOXICOGENOMIC STUDY OF HYCANTHONE,<br />
AN ANTITUMOR AGENT: MOLECULAR<br />
MECHANISMS OF HEPATOTOXICITY. A. E.<br />
Roberts, Y. Wang, X. Luo, R. Khan-Malek, V. Shultz, J.<br />
Morsman, N. Bowen, N. Bichet, O. Gillardeaux and V.<br />
Baker. <strong>Toxicology</strong>, San<strong>of</strong>i-aventis, Malvern, PA.<br />
#561 GENE EXPRESSION PROFILING IN RAT LIVER<br />
AND HEPATOCYTES TREATED WITH FIBRIC<br />
ACIDS: ANALYSIS OF THE DATA IN THE<br />
TOXICOGENONMICS PROJECT IN JAPAN. K.<br />
Tamura, T. Miyagishima, T. Urushidani and T. Nagao.<br />
Toxicogenomics Project, National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan. Sponsor: T. Inoue.<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#562 GENE EXPRESSION PROFILING IN RAT LIVER<br />
AND HEPATOCYTES TREATED WITH<br />
ETHIONINE–ANALYSIS OF THE DATA IN THE<br />
TOXICOGENOMICS PROJECT IN JAPAN -. T.<br />
Matsushita, T. Miyagishima, T. Urushidani and T.<br />
Nagao. Toxicogenomics Progect, National Institute <strong>of</strong><br />
Health Sciences, Tokyo, Japan. Sponsor: T. Inoue.<br />
#563 GENE EXPRESSION ARRAY ANALYSIS OF<br />
MALE C3H AND C57BL/6 LIVER. J. C. Fuscoe 2,1 ,<br />
A. Naito 1 , T. Han 2,1 and Y. Dragan 1 . 1 Systems<br />
<strong>Toxicology</strong>, National Center for Toxicolological<br />
Research, Jefferson, AR and 2 Center for Functional<br />
Genomics, NCTR, Jefferson, AR.<br />
#564 REGULATION OF MOUSE HEPATIC<br />
TRANSPORTERS BY PERFLUORODECANOIC<br />
ACID (PFDA). X. Cheng, J. M. Maher, M. Z. Dieter<br />
and C. D. Klaassen. Pharmacology & <strong>Toxicology</strong>,<br />
KUMC, Kansas City, KS.<br />
#565 ANALYSIS OF BENZO(A)PYRENE-INDUCED<br />
GENE EXPRESSION CHANGES IN FISHER 344<br />
RAT LIVER BY QUANTITATIVE REAL-TIME<br />
PCR. A. U. N and J. C. Means.<br />
Chemistry/Environmental Institute, Western Michigan<br />
University, Kalamazoo, MI.<br />
#566 ALTERATIONS OF GENE EXPRESSION IN<br />
FEMALE LUNG ADENOCARCINOMA CL5<br />
CELLS BY MOTORCYCLE EXHAUST<br />
PARTICULATES AND BENZO(A)PYRENE. T.<br />
Ueng and C. Hung. Institute <strong>of</strong> <strong>Toxicology</strong>, National<br />
Taiwan University, Taipei, Taiwan.<br />
#567 EXPRESSION OF GENES INVOLVED IN<br />
POLYCYCLIC AROMATIC HYDROCARBONS<br />
(PAH) TOXICITY IN HEPG2 CULTURE CELLS.<br />
F. Castorena-Torres 1 , M. Bermudez de Leon 2 , B.<br />
Cisneros 2 , J. E. Salinas-Moreno 3 and A. Albores 1 .<br />
1 <strong>Toxicology</strong> Section., Cinvestav-IPN, Mexico City,<br />
Mexico, 2 Genetics and Biology Molecular Department,<br />
Cinvestav-IPN, Mexico City, Mexico and 3 Hospital<br />
General de Zona 24, IMSS, Nueva Rosita, Coah.,<br />
Mexico.<br />
#568 EFFECTS OF DIETS CONTAINING HIGH SOY<br />
PROTEIN AND ISOFLAVONES ON GENE<br />
EXPRESSION IN FEMALE RAT LIVERS. A.<br />
Hierlihy, G. Cooke and I. Curran. <strong>Toxicology</strong> Research<br />
Division, Health Canada, Ottawa, ON, Canada.<br />
#569 A GENE SIGNATURE FOR BILE DUCT TOXINS.<br />
M. K. McMillian 1 , J. B. Parker 1 , A. M. Leone 1 , M.<br />
Kemmerer 1 , A. Y. Nie 1 , S. Bryant 1 , J. Herlich 1 , L.<br />
Yieh 2 , A. Bittner 2 , X. Liu 2 , J. Wan 2 , M. D. Johnson 1<br />
and P. G. Lord 1 . 1 Mechanistic <strong>Toxicology</strong>, Johnson &<br />
Johnson PRD, LLC, Raritan, NJ and 2 Bioinformatics &<br />
Microarrays, Johnson & Johnson PRD, LLC, La Jolla,<br />
CA.<br />
#570 CENTRAL ROLE OF LIVER RECEPTOR<br />
HOMOLOG-1 IN INDUCING LIVER-SPECIFIC<br />
GENES AND REGULATING LIPID<br />
METABOLISM IN KIDNEY OF 5/6<br />
NEPHRECTOMIZED RATS. H. Lu and C. D.<br />
Klaassen. Pharmacology and <strong>Toxicology</strong>, KU Medical<br />
Center, Kansas City, KS.<br />
#571 GENE EXPRESSION PROCESS IS A MAJOR<br />
INTRACELLULAR TARGET ASSOCIATED<br />
WITH A-NAPHTHYLISOTHIOCYANATE<br />
HEPATOTOXICITY. V. Chan 1 , A. R. Stapleton 1 and<br />
N. DelRaso 2 . 1 ManTech Environmental Technology,<br />
Inc., Wright-Patterson AFB, Dayton, OH and 2 Applied<br />
Biotechnology Branch, Human Effectiveness<br />
Directorate, Air Force Research Laboratory, Wright-<br />
Patterson AFB, Dayton, OH. Sponsor: J. Gearhart.<br />
#572 GESTATIONAL EXPOSURE TO THE<br />
PHYTOESTROGEN GENISTEIN INFLUENCES<br />
EPIGENETIC GENE REGULATION IN MICE. D.<br />
C. Dolinoy 1 , R. L. Jirtle 1 and R. A. Waterland 2 .<br />
1 Department <strong>of</strong> Radiation Oncology, Duke University<br />
Medical Center, Durham, NC and 2 Departments <strong>of</strong><br />
Pediatrics and Molecular and Human Genetics, Baylor<br />
College <strong>of</strong> Medicine, Houston, TX.<br />
#573 USING RNA INTERFERENCE TO VALIDATE<br />
MECHANISMS OF TOXICITY. J. Milano and D.<br />
Tran. Safety Assessment, AstraZeneca, Wilmington, DE.<br />
Sponsor: P. Ciaccio.<br />
#574 CIGARETTE SMOKE CONDENSATE INHIBITS<br />
PROMOTER ACTIVITY OF LYSYL OXIDASE IN<br />
CULTURED LUNG FIBROBLASTS. S. Gao 1 , Y.<br />
Zhao 1 , L. Chen 1 , D. K. Chou 1 , P. Toselli 1 , I. Chou 2 , P.<br />
Stone 1 and W. Li 1 . 1 Biochemistry, Boston University<br />
School <strong>of</strong> Medicine, Boston, MA and 2 Microbiology,<br />
Boston University School <strong>of</strong> Medicine, Boston, MA.<br />
#575 REGULATION OF THE STEROIDOGENIC<br />
ACUTE REGULATORY PROTEIN (STAR) BY<br />
TRANSFORMING GROWTH FACTOR BETA<br />
(TGF-BETA). J. Kocerha 1 , N. Denslow 1 and M.<br />
Prucha 2 . 1 Department <strong>of</strong> Physiological Sciences,<br />
University <strong>of</strong> Florida, Gainesville, FL and 2 Department<br />
<strong>of</strong> Pharmacology and Therapeutics, University <strong>of</strong><br />
Florida, Gainesville, FL.<br />
#576 COMPENSATORY CHANGES IN PHASE I, II,<br />
AND III ENZYMES IN MICE LACKING THE<br />
MULTIDRUG RESISTANCE-ASSOCIATED<br />
PROTEIN 1 (MRP1/ABCC1). J. Sivils, L. Bain, R. A.<br />
Feldman, A. J. Zimmerman and I. Gonzalez. Biology,<br />
University <strong>of</strong> Texas El Paso, El Paso, TX.<br />
#577 TIME COURSE OF HEPG2 GENE EXPRESSION<br />
FOLLOWING TREATMENT WITH<br />
THIOXANTHONE ANTITUMOR COMPOUNDS.<br />
A. E. Roberts, X. Luo, Y. Wang, R. Khan-Malek, V.<br />
Shultz, J. Morsman, N. Bowen, N. Bichet, O.<br />
Gillardeaux and V. Baker. San<strong>of</strong>i-aventis, Malvern, PA.<br />
#578 ISOLATING (NEURO)TOXIC GENE<br />
EXPRESSION SIGNATURES. P. S. Spencer and N.<br />
and. Center for Research on Occupational and<br />
Environmental <strong>Toxicology</strong>, Oregon Health & Science<br />
University, Portland, OR.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 89
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#579 PREDICTION OF TRANSCRIPTION FACTORS<br />
COMMONLY AFFECTED BY GLUTAMATE-<br />
CYSTEINE LIGASE EXPRESSION IN MICE<br />
EXPOSED TO ACETAMINOPHEN, CARBON<br />
TETRACHLORIDE OR TUMOR NECROSIS<br />
FACTOR. S. Shi, D. Botta, T. Bammler, R. P. Beyer<br />
and T. J. Kavanagh. Environmental and Occupational<br />
Health Sciences, University <strong>of</strong> Washington, Seattle,<br />
WA.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RECEPTOR: PPAR<br />
Chairperson(s): Andrew Burdick, Penn State University, University Park, PA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#580 MOLECULAR MECHANISMS OF PPARA-<br />
MEDIATED GENE EXPRESSION OF PXR. S.<br />
aouabdi, G. Gibson and N. Plant. school <strong>of</strong> biological<br />
and molecular sciences, university <strong>of</strong> surrey, guildford,<br />
surrey, United Kingdom.<br />
#581 DECREASED LONGEVITY AND<br />
ENHANCEMENT OF AGE-DEPENDENT<br />
LESIONS IN MICE LACKING THE NUCLEAR<br />
RECEPTOR PEROXISOME PROLIFERATOR-<br />
ACTIVATED RECEPTOR ALPHA. P. Howroyd 1,2 ,<br />
C. Swanson 1 , C. Dunn 1 , R. C. Cattley 1,3 and J. C.<br />
Corton 4,1 . 1 CIIT, Research Triangle Park, NC, 2 EPL,<br />
Research Triangle Park, NC, 3 Amgen, Thousand Oaks,<br />
CA and 4 ToxicoGenomics, Chapel Hill, NC.<br />
#582 CONSTITUTIVE EXPRESSION OF<br />
PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR ALPHA-REGULATED GENES IN<br />
DWARF MICE. A. J. Stauber 2 , J. Liu 4 , M. P.<br />
Waalkes 4 , H. Brown-Borg 3 , K. A. Voss 5 , J. J.<br />
Kopchick 6 and J. C. Corton 1,2 . 1 ToxicoGenomics,<br />
Chapel Hill, NC, 2 CIIT Centers for Health Research,<br />
Research Triangle Park, NC, 3 University <strong>of</strong> North<br />
Dakota, Grand Forks, ND, 4 NCI at NIEHS, Research<br />
Triangle Park, NC, 5 USDA, Athens, GA and 6 Ohio<br />
University, Athens, OH.<br />
#583 PEROXISOME PROLIFERATOR ACTIVATED<br />
RECEPTOR β (PPARβ) REGULATES<br />
EXPRESSION OF CANCER-RELATED GENES<br />
IN LIVER. W. Shan 1,2 and J. M. Peters 1 . 1 Department<br />
<strong>of</strong> Veterinary Science and Center for Molecular<br />
<strong>Toxicology</strong> and Carcinogenesis, The Pennsylvania<br />
State University, University Park, PA and 2 The<br />
Intercollege Graduate Degree <strong>Program</strong> in Genetics,<br />
The Pennsylvania State University, University Park,<br />
PA.<br />
#584 GENE EXPRESSION PATTERNS ASSOCIATED<br />
WITH FENOFIBRATE INDUCED MYOPATHY.<br />
N. R. Bordelon, B. H. Romach, R. Brown and R. T.<br />
Miller. SA, GSK, Research Triangle Park, NC.<br />
#585 EVALUATION OF THE ACTIVITY OF THE<br />
PESTICIDE CYHALOFOP-BUTYL IN A<br />
PEROXISOME-PROLIFERATOR RECEPTOR-α<br />
REPORTER ASSAY. G. D. Charles 1 , L. Kan 1 , T. R.<br />
Hanley 2 and B. B. Gollapudi 1 . 1 The Dow Chemical<br />
Company, Midland, MI and 2 Dow AgroSciences LLC,<br />
Indianapolis, IN.<br />
#586 PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR β (PPARβ) SELECTIVELY<br />
REGULATES KERATINOCYTE<br />
DIFFERENTIATION AND PROLIFERATION. D.<br />
J. Kim 1,2 , A. N. Billin 3 , T. M. Willson 3 and J. M.<br />
Peters 1,2 . 1 Department <strong>of</strong> Veterinary Science and The<br />
Center for Molecular <strong>Toxicology</strong> and Carcinogenesis,<br />
The Pennsylvania State University, University Park,<br />
PA, 2 Graduate <strong>Program</strong> in Molecular <strong>Toxicology</strong>, The<br />
Huck Institute for Life Sciences, The Pennsylvania<br />
State University, University Park, PA and 3 Discovery<br />
Research, GlaxoSmithKline, Research Triangle Park,<br />
NC.<br />
#587 THE PEROXISOME PROLIFERATOR-<br />
ACTIVATED RECEPTOR β (PPARβ) AGONIST<br />
GW0742 INHIBITS SKIN CARCINOGENESIS.<br />
M. K. Devlin 1,2 , D. J. Kim 1 , A. N. Billin 3 , T. M.<br />
Willson 3 and J. M. Peters 1,2 . 1 Department <strong>of</strong><br />
Veterinary Sciences and The Center for Molecular<br />
<strong>Toxicology</strong> and Carcinogenesis, Penn State University,<br />
University Park, PA, 2 Graduate <strong>Program</strong> in Molecular<br />
Medicine, Huck Institute for Life Sciences,<br />
Pennsylvania State University, University Park, PA and<br />
3 Discovery Research, GlaxoSmithKline, Research<br />
Triangle Park, NC.<br />
#588 TRANSCRIPTIONAL REGULATION OF<br />
TISSUE-SPECIFIC INHIBITOR OF MATRIX<br />
METALLOPROTEINASE 1 (TIMP1) BY<br />
PEROXISOME PROLIFERATOR-ACTIVATOR<br />
RECEPTOR β (PPARβ). M. T. Bility 1,2 , D. J. Kim 1,2 ,<br />
A. N. Billin 3 , T. M. Willson 3 and J. M. Peters 1,2 .<br />
1 Department <strong>of</strong> Veterinary Science and The Center for<br />
Molecular <strong>Toxicology</strong> and Carcinogenesis, The<br />
Pennsylvania State University, University Park, PA,<br />
2 Graduate <strong>Program</strong> in Molecular <strong>Toxicology</strong>, The<br />
Huck Institutes for Life Sciences, The Pennsylvania<br />
State University, University Park, PA and 3 Discovery<br />
Research, GlaxoSmithKline, Research Triangle Park,<br />
NC.<br />
#589 TRANSCRIPTION PROFILING REVEALS<br />
HEPATIC HYPERTROPHY TO BE<br />
INDISTINGUISHABLE FROM THE<br />
PHARMACOLOGY OF PPARα AGONISM IN<br />
THE RAT. A. T. De Souza 1 , P. D. Cornwell 1 , X. Dai 2 ,<br />
M. J. Caguyong 3 and R. G. Ulrich 1 . 1 Preclinical<br />
Molecular Pr<strong>of</strong>iling, Rosetta Inpharmatics, a wholly<br />
owned subsiduary <strong>of</strong> Merck & Co. Inc., Seattle, WA,<br />
2 Informatics, Rosetta Inpharmatics, a wholly owned<br />
subsiduary <strong>of</strong> Merck & Co. Inc., Seattle, WA and<br />
3 Project Management, Rosetta Inpharmatics, a wholly<br />
owned subsiduary <strong>of</strong> Merck & Co. Inc., Seattle, WA.<br />
90<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NEUROTOXICITY OF METALS: DOSIMETRY<br />
AND EFFECTS<br />
Chairperson(s): Donald Smith, University <strong>of</strong> California Santa Cruz, Santa<br />
Cruz, CA and Vanessa Fitsanakis, Vanderbilt University Medical Center,<br />
Nashville, TN.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#590 DISTRIBUTION OF COPPER (CU) AND ZINC<br />
(ZN) TRANSPORTER IN RAT CHOROID<br />
PLEXUS, BRAIN REGIONAL CAPILLARIES,<br />
AND CHOROIDAL Z310 CELLS BY REAL TIME<br />
RT-PCR. M. Chigurupati, G. Li, B. Choi, S. X. Wang<br />
and W. Zheng. School <strong>of</strong> Health Sciences, Purdue<br />
University, West Lafayette, IN.<br />
#591 COPPER (CU) TRANSPORT AND<br />
TRANSPORTERS IN THE BLOOD-BRAIN<br />
BARRIER (BBB) AND BLOOD-CSF BARRIER<br />
(BCB). B. Choi, J. S. Crossgrove, M. Chigurupati and<br />
W. Zheng. School <strong>of</strong> Health Sciences, Purdue<br />
University, West Lafayette, IN.<br />
#592 THE EFFECTS OF COPPER<br />
DIMETHYLDITHIOCARBAMATE (CDDC) ON<br />
RAT HIPPOCAMPAL ASTROCYTES. L. Passaint<br />
and L. D. Trombetta. Pharmaceutical Sciences, St. Johns<br />
Universtty, Jamaica, NY.<br />
#593 MANGANESE EXPOSURE ALTERS IRON<br />
REGULATORY MECHANISMS AT BLOOD-<br />
CEREBROSPINAL FLUID BARRIER (BCB) AND<br />
SELECTED REGIONS OF BLOOD-BRAIN<br />
BARRIER (BBB) IN RATS. G. Li 1 , J. Liu 2 , M. P.<br />
Waalkes 2 and W. Zheng 1 . 1 School <strong>of</strong> Health Sciences,<br />
Purdue University, West Lafayette, IN and 2 Inorganic<br />
Carcinogenesis Section, NCI at NIEHS, Research<br />
Triangle Park, NC.<br />
#594 OVEREXPRESSION OF DMT1 IN THE<br />
CHOROID PLEXUS FOLLOWING MANGANESE<br />
(MN) EXPOSURE. X. Wang, J. G. Li and W. Zheng.<br />
Health Sciences, Purdue University, West Lafayette, IN.<br />
Sponsor: W. Zheng.<br />
#595 IRON DEFICIENT AND MANGANESE<br />
ENHANCED DIETS ALTER METALS AND<br />
TRANSPORTERS IN THE DEVELOPING RAT<br />
BRAIN. S. J. Garcia 1 , T. Syversen 2 , K. Gellein 3 and M.<br />
Aschner 4 . 1 Physiology/ Pharmacology, Wake Forest<br />
University Health Sciences, Winston Salem, NC,<br />
2 Neuroscience, Norwegian University <strong>of</strong> Science &<br />
Technology, Trondheim, Norway, 3 Chemistry,<br />
Norwegian University <strong>of</strong> Science & Technology,<br />
Trondheim, Norway and 4 Pediatrics, Vanderbilt<br />
University Medical Center, Nashville, NC.<br />
#596 INFLUENCE OF SUBACUTE MANGANESE<br />
SULFATE ON DOPAMINE AND N-METHYL-D-<br />
ASPARTATE RECEPTORS. H. Komiskey. Xavier<br />
University <strong>of</strong> Louisiana, New Orleans, LA.<br />
#597 BIOLOGICAL MARKERS OF MN EXPOSURE:<br />
RELATIONSHIPS BETWEEN MN DOSE,<br />
PARTITIONING IN BLOOD, AND<br />
ACCUMULATION IN BRAIN. C. Kern 1 , L. Cadena 1 ,<br />
R. Gwiazda 1 , R. Lucchini 2 and D. R. Smith 1 .<br />
1 Environmental <strong>Toxicology</strong>, University <strong>of</strong> California,<br />
Santa Cruz, CA and 2 Institute <strong>of</strong> Occupational Health,<br />
University <strong>of</strong> Brescia, Brescia, Italy.<br />
#598 PROGRESSION OF NEUROCHEMICAL<br />
EFFECTS IN DIFFERENT BRAIN REGIONS AS A<br />
FUNCTION OF THE MAGNITUDE AND<br />
DURATION OF MANGANESE EXPOSURE. R.<br />
Gwiazda, C. Kern and D. Smith. Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California, Santa Cruz, Santa<br />
Cruz, CA.<br />
#599 DETERMINATION OF DEPLETED URANIUM<br />
(DU) IN RATS FOLLOWING 6-MONTH<br />
EXPOSURE TO SURGICALLY IMPLANTED DU<br />
PELLETS. V. A. Fitsanakis 1 , K. M. Erikson 2 , S. J.<br />
Garcia 3 , T. L. Syversen 4 and M. Aschner 1 . 1 Pediatrics,<br />
Vanderbilt University Medical Center, Nashville, TN,<br />
2 3 Nutrition, UNC-G, Greensboro, NC, Physiology &<br />
Pharmacology, Wake Forest University Medical School,<br />
Winston-Salem, NC and 4 Neuroscience, Norwegian<br />
University <strong>of</strong> Science & Technology, Trondheim,<br />
Norway.<br />
#600 NEUROLOGICAL EFFECTS OF ACUTE<br />
URANIUM EXPOSURE. D. Barber 1 , S. Hancock, 2 ,<br />
A. McNally 1 , J. Hinckley 2 , E. Binder 2 , M. Ehrich 2 and<br />
B. Jortner 2 . 1 Center for Environmental and Human<br />
<strong>Toxicology</strong>, University <strong>of</strong> Florida, Gainesville, FL and<br />
2 Laboratory for Neurotoxicity Studies, VPI&SU,<br />
Blacksburg, VA.<br />
#601 DIFFERENTIAL EFFECT OF LEAD (PB)<br />
EXPOSURE ON THE N-METHYL-D-ASPARTATE<br />
(NMDA) INDUCED INWARD CURRENT IN<br />
DOPAMINE (DA)-CONTAINING NEURONS AND<br />
HIPPOCAMPAL CA1 NEURONS. D. K. Pitts and M.<br />
W. Lewis. Pharmaceutical Sciences, Wayne State<br />
University, Detroit, MI.<br />
#602 ORAL EXPOSURE TO INORGANIC LEAD (PB)<br />
IN RATS: BLOOD CONCENTRATIONS, BRAIN<br />
CONCENTRATIONS AND EFFECTS ON<br />
ACOUSTIC STARTLE. R. Commissaris, A. Davis and<br />
D. K. Pitts. Pharmaceutical Sciences, Wayne State<br />
University, Detroit, MI.<br />
#603 LIPID PEROXIDATION AND DISTRIBUTION OF<br />
INORGANIC ARSENIC AND ITS METABOLITES<br />
IN RAT NERVOUS SYSTEM. E. Garcia-Chavez 1 , I.<br />
Jimenez 2 , B. Segura 3 , L. C. Sanchez-Pena 1 , J. C.<br />
Guadarrama 2 and L. M. Del Razo 1 . 1 <strong>Toxicology</strong>,<br />
Cinvestav-IPN, Mexico D.F., Mexico, 2 Physiol.<br />
Biophys. & Neurosci., Cinvestav-IPN, Mexico D.F.,<br />
Mexico and 3 FES-Iztacala, UNAM, Mexico D.F.,<br />
Mexico.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 91
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#604 EFFECT OF INORGANIC ARSENIC EXPOSURE<br />
INITIATING FROM IN UTERO THROUGH<br />
AFTER BIRTH ON THE NEUROBEHAVIOR AND<br />
NEUROTRANSMITTERS IN THE BRAIN OF<br />
MOUSE OFFSPRING. T. Itoh 1 , Y. Nakagi 1 , K.<br />
Nakai 2 , H. Sato 2 , C. Watanabe 3 , H. Yamauchi 4 and T.<br />
Yoshida 1 . 1 Asahikawa Medical College, Asahikawa,<br />
Japan, 2 Tohoku University, Sendai, Japan, 3 Tokyo<br />
University, Tokyo, Japan and 4 St. Marianna Medical<br />
College, Kawasaki, Japan.<br />
#605 NEUROBEHAVIORAL CHANGES IN<br />
METALLOTHIONEIN-NULL MICE<br />
PRENATALLY EXPOSED TO MERCURY VAPOR.<br />
M. Yoshida 1 , C. Watanabe 2 , K. Horie 1 , M. Satoh 3 , M.<br />
Sawada 4 and A. Shimada 4 . 1 Department <strong>of</strong><br />
Biochemistry, St. Marianna University School <strong>of</strong><br />
Medicine, Kawasaki, Japan, 2 Department <strong>of</strong> Human<br />
Ecology, Graduate School <strong>of</strong> Medicine, University <strong>of</strong><br />
Tokyo, Tokyo, Japan, 3 Department <strong>of</strong> Hygienics, Gifu<br />
Pharmaceutical University, Gifu, Japan and<br />
4 Department <strong>of</strong> Veterinary Pathology, Tottori University,<br />
Tottori, Japan.<br />
#606 MERCURY EXPOSURE OF MOTHERS AND<br />
NEWBORNS IN SURINAM: A PILOT STUDY. S.<br />
Mohan 1 , M. Tiller 2 , G. B. Vandervoet 2 , H. Kanhai 2 and<br />
F. A. de Wolff 2 . 1 Department <strong>of</strong> Obstetrics and<br />
Gynecology, ‘s Lands Hospital, Gravenstratt,<br />
Netherlands and 2 <strong>Toxicology</strong> Laboratory, Leiden<br />
University Medical Center, Leiden, Netherlands.<br />
#607 THE EFFECTS OF TRIBUTYLTIN (TBT)<br />
CHLORIDE ON DOPAMINE METABOLISM IN<br />
BRAIN TISSUES OF FEMALE MICE AFTER<br />
SUBACUTE ORAL EXPOSURE. M. Tsunoda 1 , Y.<br />
Kudo 1 , K. Nakano 2 , N. Konno 3 , Y. Sugita-Konishi 4 and<br />
Y. Aizawa 1 . 1 Preventive Medicine and Public Health,<br />
Kitasato University School <strong>of</strong> Medicine, Sagamihara,<br />
Kanagawa, Japan, 2 Fukushima Prefecture Ken-poku<br />
Public Health and Welfare Office, Fukushima, Japan,<br />
3 Home Economics, Koriyama Women’s University,<br />
Koriyama, Fukushima, Japan and 4 Division <strong>of</strong><br />
Microbiology, National Institute <strong>of</strong> Health Sciences,<br />
Setagaya-ku, Tokyo, Japan.<br />
#608 BLOOD BRAIN BARRIER (BBB) DISRUPTION<br />
AFTER VANADIUM INHALATION. M. AVILA-<br />
COSTA 1,2 , A. Zepeda-Rodriguez 2 , L. Colin-Barenque 1 ,<br />
F. Pasos 2 , P. Aley 1 , A. Gonzalez-Villalva 2 , P. Mussali-<br />
Galante 2 , J. Ordonez-Librado 1 , A. Gutierrez-Valdez 1 , V.<br />
Rodriguez-Lara 2 , A. Reyes-Olivera 1 , G. Pinon-Zarate 2 ,<br />
M. Rojas-Lemus 2 , V. Delgado 2 , B. Chavez 2 and T. I.<br />
Fortoul 2 . 1 Neurosciencias, UNAM, Mexico, D.F.,<br />
Mexico and 2 Biologia Celular Y Tisular, UNAM,<br />
Mexico, D.F., Mexico.<br />
#609 CYTOTOXIC EFFECTS OF TELLURIUM<br />
TETRACHLORIDE AND (4-METHOXYPHENYL)<br />
TRICHLOROTELLURIUM ON RAT<br />
HIPPOCAMPAL ASTROCYTES. M. Aravantinou 2<br />
and D. Hardej 1 . 1 Pharmaceutical Sciences, St. John’s<br />
University, Jamaica, NY and 2 Biological Sciences, St.<br />
John’s University, Jamaica, NY.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NEUROTOXICITY OF METALS: MECHANISMS<br />
Chairperson(s): Richard Seegal, New York State Department <strong>of</strong> Health,<br />
Albany, NY and Damani Parran, National Institute <strong>of</strong> Environmental Health<br />
Science, Raleigh, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#610 TMT-INDUCED NEUROGENESIS IN THE ADULT<br />
MOUSE HIPPOCAMPUS. B. C. Weig, K. R. Reuhl<br />
and H. E. Lowndes. Department <strong>of</strong> Pharmacology and<br />
<strong>Toxicology</strong>, Joint Graduate <strong>Program</strong> in <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ.<br />
#611 NEURONAL MICROTUBULE DAMAGE CAUSED<br />
BY IN VITRO EXPOSURE TO LEAD AND<br />
METHYLMERCURY. J. L. Bisson 1 and K. R.<br />
Reuhl 1,2 . 1 Joint Graduate <strong>Program</strong> in <strong>Toxicology</strong>,<br />
Rutgers/UMDNJ, Piscataway, NJ and 2 Neurotoxicology<br />
Labs, Department <strong>of</strong> Pharmacology and <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ.<br />
#612 THE EFFECTS OF MANCOZEB ON THE<br />
MICROTUBULAR ARCHITECTURE OF RAT<br />
HIPPOCAMPAL ASTROCYTES. M. M. Tsang and L.<br />
D. Trombetta. Pharmaceutical Sciences, St. Johns<br />
Universtty, Jamaica, NY.<br />
#613 NEUROPROTECTIVE EFFECTS OF<br />
MELATONIN ON NEUROBLASTOMA CELLS<br />
EXPOSED TO LEAD. C. S. Chetty 1 , A. O. Dennis 1 , J.<br />
Heinz 1 , M. C. Vemuri 2 and C. Suresh 1 . 1 Natural<br />
Sciences and Mathematics, Savannah State University,<br />
Savannah, GA and 2 Surgery, Children’s Hospital <strong>of</strong><br />
Philadelphia, Philadelphia, PA.<br />
#614 BLOCKAGE OF INTERLEUKIN-6 SECRETION<br />
FROM ASTROGLIA BY LEAD: INVOLVEMENT<br />
OF GRP78. Y. Qian 1 , F. Valencia 1 , Y. Zheng 1 , K. S.<br />
Ramos 2 and E. Tiffany-Castiglioni 1 . 1 Texas A&M<br />
University, College Station, TX and 2 University <strong>of</strong><br />
Louisville Health Sciences Center, Louisville, KY.<br />
#615 MANGANESE INDUCED APOPTOSIS IN SH-<br />
SY5Y HUMAN NEUROBLASTOMA CELLS. A. P.<br />
Stephenson and R. Reams. College <strong>of</strong> Pharmacy, Florida<br />
A&M University, Tallahassee, FL.<br />
#616 THE MODULATION OF METALLOTHIONEIN-3<br />
(MT-3) EXPRESSION IN MOUSE ASTROCYTES<br />
IN RESPONSE TO PROINFLAMMATORY<br />
MEDIATORS, SECOND MESSENGER<br />
ACTIVATORS, AND CELL STRESS. S. H. Garrett.<br />
Pathology, University <strong>of</strong> North Dakota, Grand Forks,<br />
ND.<br />
#617 MANGANESE-INDUCED ALTERATIONS IN NFκB-RELATED<br />
GENE EXPRESSION BY<br />
ACTIVATED MICROGLIA. P. L. Crittenden and N.<br />
M. Filipov. Center for Environmental Health Sciences,<br />
Basic Sciences, Coll. Vet. Med., Mississippi State<br />
University, Mississippi State, MS.<br />
92<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#618 DIFFERENTIAL GENE EXPRESSION AT TWO<br />
DOSES OF METHYLMERCURY IN MOUSE<br />
CEREBELLA AS ANALYZED BY APOPTOSIS-<br />
SPECIFIC MICROARRAY. K. A. Thuett, S. Bellum<br />
and L. C. Abbott. Veterinary Integrative Biosciences,<br />
Texas A&M University / College <strong>of</strong> Veterinary<br />
Medicine & Biomedical Sciences, College Station, TX.<br />
#619 FORMATION OF REACTIVE OXYGEN SPECIES<br />
IN CEREBELLAR GRANULE CELLS OF MICE<br />
EXPOSED TO METHYLMERCURY. S. Bellum, K.<br />
A. Thuett and L. C. Abbott. Veterinary Integrative<br />
Biosciences, Texas A&M University, College Station,<br />
TX.<br />
#620 METHYLMERCURY (MEHG)-INDUCED<br />
REACTIVE OXYGEN SPECIES (ROS) LEVELS<br />
ARE MODULATED BY INTRACELLULAR<br />
REDOX. M. Aschner 2 , G. Shanker 1 , T. Syversen 3 , J.<br />
Aschner 2 and U. Sonnewald 3 . 1 Physiology and<br />
Pharmacology, Wake Forest University School <strong>of</strong><br />
Medicine, Winston Salem, NC, 2 Pediatrics, Vanderbilt<br />
University Medical Center, Nashville, TN and<br />
3 Neuroscience, University <strong>of</strong> Trondheim, Trondheim,<br />
Norway.<br />
#621 EFFECTS OF METHYLMERCURY ON<br />
MITOCHONDRIAL FUNCTION AND REACTIVE<br />
OXYGEN SPECIES FORMATION IN STRIATAL<br />
SYNAPTOSOMES FROM RAT. A. Dreiem 1 and R. F.<br />
Seegal 1,2 . 1 New York State Department <strong>of</strong> Health,<br />
Wadsworth Center, Albany, NY and 2 School <strong>of</strong> Public<br />
Health, University at Albany, Albany, NY.<br />
#622 POTENTIATION OF MITOCHONDRIAL<br />
SUSCEPTIBILITY, OXIDATIVE STRESS AND<br />
NF-KB SIGNALING FOLLOWING CHEMICAL<br />
MIXTURE (LEAD AND ARSENIC)-INDUCED<br />
NEUROTOXICITY. R. Yasmeen, G. Hashim, O.<br />
Ogunmosin, D. Ghosh and P. G. Gunasekar. Biology,<br />
Texas Southern University, Houston, TX.<br />
#623 EFFECTS OF GABA- B RECEPTOR ACTIVATION<br />
& INHIBITON ON METHYLMERCURY-<br />
INDUCED ALTERATIONS OF INTRACELLULAR<br />
CA IN RAT CEREBELLAR GRANULE<br />
NEURONS. D. K. Atchison and W. D. Atchison.<br />
Department Pharmacology/<strong>Toxicology</strong>, Mich State<br />
University, East Lansing, MI.<br />
#624 COMPARATIVE EFFECTS OF<br />
METHYLMERCURY (MEHG) ON<br />
INTRACELLULAR CA IN RAT CEREBELLAR<br />
GRANULE & CORTICAL NEURONS IN<br />
CULTURE. A. Segarra and W. D. Atchison. Department<br />
Pharmacology/<strong>Toxicology</strong>, Mich State University, East<br />
Lansing, MI.<br />
#625 EFFECTS OF SEMI-CHRONIC<br />
METHYLMERCURY EXPOSURE ON<br />
INTRACELLULAR CALCIUM LEVELS IN RAT<br />
UNDIFFERENTIATED PC12 CELLS. S. Baker 2,1<br />
and W. D. Atchison 1,2 . 1 Department<br />
Pharmacology/<strong>Toxicology</strong>, Mich State University, East<br />
Lansing, MI and 2 Coll Vet. Med., Mich State<br />
University, East Lansing, MI.<br />
#626 EFFECTS OF THIMEROSAL ON NGF SIGNAL<br />
TRANSDUCTION AND CELL DEATH IN<br />
NEUROBLASTOMA CELLS. D. K. Parran, A. M.<br />
Barker and M. F. Ehrich. Biomedical Sciences, Virginia<br />
Tech, Blacksburg, VA.<br />
#627 METHYL MERCURY (MEHG) ALTERS IL-6<br />
SIGNAL TRANSDUCTION IN MOUSE<br />
CEREBELLAR CELLS IN CULTURE. E. S.<br />
Calderon-Aranda 1,2 , L. C. Acosta-Saavedra 2 and E. K.<br />
Silbergeld 1 . 1 EHS, BSPH, Johns Hopkins University,<br />
Baltimore, MD and 2 Toxicologia, Cinvestav, Mexico,<br />
DF, Mexico.<br />
#628 ACUTE EXPOSURE TO URANYL ION (UO2) IN<br />
VITRO DIMINISHES K+-STIMULATED<br />
GLUTAMATE/GABA RELEASE INDEPENDENT<br />
OF EXTRACELLULAR CALCIUM. S. M. Lasley<br />
and K. R. Vietti. Biomedical & Therapeutic Sciences,<br />
University <strong>of</strong> Illinois College <strong>of</strong> Medicine, Peoria, IL.<br />
#629 EFFECTS OF LOW-LEVEL MN EXPOSURE ON<br />
THE METABOLISM OF AMINO ACIDS, GABA,<br />
AND CELLULAR RESPIRATION IN<br />
GABAERGIC AF5 NEURAL CELLS. D. R. Crooks 1 ,<br />
N. Welch 1 , A. F. Rosenthal 1 , J. Sanchez 2 , W. J. Freed 2<br />
and D. R. Smith 1 . 1 Environmental <strong>Toxicology</strong>,<br />
University <strong>of</strong> Calif. Santa Cruz, Santa Cruz, CA and<br />
2 Cellular Neurobiology Branch, National Institute on<br />
Drug Abuse, Baltimore, MD.<br />
#630 MN ALTERS CELLULAR COMT-1,<br />
SECRETOGRANIN II, AND UCH-LI LEVELS IN<br />
PC12 CELLS: IMPLICATIONS FOR MN<br />
NEUROTOXICITY. D. R. Smith, S. Reaney, S.<br />
Whitman, R. Gwiazda and T. Holman. Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California, Santa Cruz, CA.<br />
#631 MANGANESE INHIBITS THE BINDING OF THE<br />
COCAINE ANALOG [ 3 H]-WIN 35, 428 TO THE<br />
DOPAMINE TRANSPORTER (DAT) FROM RAT<br />
STRIATUM. M. Chen, E. Furukawa and T. R. Guilarte.<br />
Environmental Health Sciences, Johns Hopkins<br />
University Bloomberg School <strong>of</strong> Public Health,<br />
Baltimore, MD.<br />
#632 DIFFERENTIAL EFFECTS OF MANGANESE<br />
(MN) AND MPP + IN DIFFERENTIATED AND<br />
NON-DIFFERENTIATED PC12 CELLS. L. T.<br />
Russel, K. S. Squibb and A. M. Elnabawi. <strong>Program</strong> in<br />
<strong>Toxicology</strong>, University <strong>of</strong> Maryland School <strong>of</strong><br />
Medicine, Baltimore, MD.<br />
#633 NEUROTOXIC EFFECT OF MANGANESE AND<br />
NEUROPROTECTIVE EFFECT OF COPPER IN A<br />
CELL CULTURE MODEL OF PRION DISEASES.<br />
C. J. Choi, V. Anantharam, A. Kanthasamy and A.<br />
Kanthasamy. Biomedical Sciences, Iowa State<br />
University, Ames, IA.<br />
#634 MECHANISM OF ARSENIC PERIPHERAL<br />
NEUROTOXICITY. A. Vahidnia, G. B. Vandervoet<br />
and F. A. de Wolff. <strong>Toxicology</strong> Laboratory, Leiden<br />
University Medical Center, Leiden, Netherlands.<br />
Abstract 635 is located on page 97.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 93
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room RO6<br />
SUNSET SESSION: BROMINATED FLAME RETARDANTS: NEW<br />
FINDINGS<br />
Chairperson(s): Arnold Schecter, University <strong>of</strong> Texas School <strong>of</strong> Public Health,<br />
Dallas, TX and Linda Birnbaum, U.S. EPA, Research Triangle Park, NC.<br />
Endorsed by:<br />
Neurotoxicology SS<br />
Occupational and Public Health SS*<br />
Reproductive and Development SS<br />
Risk Assessment SS<br />
The brominated flame retardants are new potential public health hazards. They<br />
resemble PCBs and are found worldwide. They can be found in carpets, styr<strong>of</strong>oam,<br />
and in household and <strong>of</strong>fice electrical equipment. Brominated flame<br />
retardants (BFRs), especially the common polybrominated diphenyl ethers<br />
(PBDEs) have recently been reported in humans at markedly increasing levels<br />
in blood and milk. The highest levels in humans and food worldwide have been<br />
reported in US samples. Studies <strong>of</strong> milk report 10-100 times higher levels in US<br />
than in European women. US food levels are highest in fish, then meat, and<br />
finally dairy. All human and food samples measured to date are contaminated<br />
with many <strong>of</strong> the 13 commonly reported PBDE congeners, although the<br />
congener pattern can vary in different specimens. Blood and milk levels in the<br />
USA are currently similar. PBDEs cannot be measured in 1973 blood, and are<br />
increasing markedly in humans in the USA (at the same time dioxins and PCBs<br />
are decreasing). No human health studies <strong>of</strong> these compounds have been<br />
published but cell culture and laboratory animal studies suggest certain adverse<br />
health effects, similar to those reported for PCBs which the PBDEs structurally<br />
resemble. New findings will be presented for human tissue levels and food<br />
levels in the USA and worldwide in the general population and in specially<br />
exposed workers. The uncertainty regarding toxicity <strong>of</strong> various congeners will<br />
be reviewed and compared to the dioxin toxic equivalency factor concept. No<br />
such toxicity comparison factors are available for the PBDEs at the present time<br />
making it difficult to decide which congeners should be measured. There is<br />
currently no consensus on which to be measured; this topic will be reviewed and<br />
recommendations made. Temporal trends in human PBDE levels will be<br />
presented and compared with temporal trend for dioxins, dibenz<strong>of</strong>urans and<br />
PCBs. New toxicological findings with respect to pharmacokinetics, neurological,<br />
reproductive and developmental, endocrine, and cancer endpoints will be<br />
presented. Finally, human risk assessment will be considered.<br />
#309 4:30 BROMINATED FLAME RETARDANTS: NEW<br />
FINDINGS. L. Birnbaum 1 and A. J. Schecter. 1 U.S.<br />
EPA, Research Triangle Park, NC and 2 Environmental<br />
Sciences, University <strong>of</strong> Texas School <strong>of</strong> Public Health,<br />
Dallas, TX.<br />
#310 4:40 PBDES IN US HUMANS, FOOD AND<br />
ENVIRONMENTAL SAMPLES. A. J. Schecter 1 , O.<br />
Paepke 2 , J. Ryan 3 , L. Birnbaum 4 , D. Staskal 5 and K.<br />
Tung 1 . 1 Environmental Sciences, University <strong>of</strong> Texas<br />
School <strong>of</strong> Public Health, Dallas, TX, 2 ERGO<br />
Laboratory, Hamburg, Germany, 3 Health Canada,<br />
Ottawa, ON, Canada, 4 U.S. EPA, Research Triangle<br />
Park, NC and 5 UNC, Chapel Hill, NC.<br />
#311 4:55 TOXICOKINETICS OF BDE 47 IN MICE. D.<br />
Staskal 1 , J. J. Diliberto 2 , M. J. DeVito 2 and L. S.<br />
Birnbaum 2 . 1 UNC Curriculum in <strong>Toxicology</strong>, Research<br />
Triangle Park, NC and 2 ETD, NHEERL, ORD, U.S.<br />
EPA, Research Triangle Park, NC.<br />
#312 5:10 DEVELOPMENTAL NEUROTOXICITY OF<br />
PBDES IN MICE AND RATS. H. Viberg, A.<br />
Fredriksson and P. Eriksson. Environmental <strong>Toxicology</strong>,<br />
Uppsala University, Uppsala, Sweden.<br />
#313 5:25 PBDE LEVELS AMONG US WOMEN, DAILY<br />
INTAKE AND RISK OF HARM TO THE<br />
DEVELOPING BRAIN AND REPRODUCTIVE<br />
ORGANS. T. A. McDonald. Office <strong>of</strong> Environmental<br />
Health Hazard Assessment, California Environmental<br />
Protection Agency, Oakland, CA. Sponsor: L. Zeise.<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room RO8<br />
SUNSET SESSION: DEVELOPMENTAL TOXICOLOGY<br />
EVALUATIONS: ISSUES WITH INCLUDING NEUROTOXICOLOGY<br />
AND IMMUNOTOXICOLOGY ASSESSMENTS<br />
Chairperson(s): Gregory S. Ladics, DuPont Co., Newark, DE and Leigh Ann<br />
Burns Naas, Pfizer, Inc., San Diego, CA.<br />
Endorsed by:<br />
Immunotoxicology SS*<br />
Neurotoxicology SS<br />
Risk Assessment SS<br />
Evaluation <strong>of</strong> <strong>of</strong>fspring following maternal exposures during gestation and<br />
lactation (i.e. reproductive/developmental toxicology [RDT]) has historically<br />
been a routine part <strong>of</strong> the safety assessment process. Recently, increased attention<br />
has focused on the effects <strong>of</strong> agricultural and industrial chemicals, as well<br />
as pharmaceuticals, on the developing nervous and immune systems <strong>of</strong> the fetus<br />
and newborn. This new focus on developmental neurotoxicology (DNT) and<br />
developmental immunotoxicology (DIT) is based on the premise that the developing<br />
nervous and immune systems may be qualitatively and/or quantitatively<br />
more susceptible to chemical perturbation compared to the adult and studies<br />
conducted currently may be insufficient to protect the young. DNT studies have<br />
become common for agricultural chemicals, following the preparation <strong>of</strong> test<br />
guidelines from the U.S. EPA (OPPTS 870.6300, 1998) and OECD (TG 426,<br />
draft). With increased DNT testing and the prospect <strong>of</strong> new DIT test guidelines,<br />
there has been considerable interest in both DNT and DIT, with many scientific<br />
workshops, roundtables, symposia, as well as sponsored research devoted to the<br />
subjects. The intent <strong>of</strong> this session is to highlight and discuss issues that are<br />
common to RDT, DNT, and DIT, including the consequences <strong>of</strong> high dose selection<br />
and maternal toxicity; the adequacy <strong>of</strong> pup exposure during lactation;<br />
whether a different dosing paradigm should be applied to RDT vs. DNT or DIT<br />
studies; whether DIT and DNT endpoints can be incorporated into a single<br />
(RDT) study for hazard identification purposes (e.g., for screening purposes,<br />
what endpoints have proven their value and should be retained). This session<br />
will provide a forum to discuss how assessment <strong>of</strong> RDT, DIT, and DNT could<br />
be integrated for hazard identification purposes and to reduce animal usage.<br />
#314 4:30 DEVELOPMENTAL TOXICOLOGY<br />
EVALUATIONS: ISSUES WITH INCLUDING<br />
NEUROTOXICOLOGY AND<br />
IMMUNOTOXICOLOGY ASSESSMENTS. G. S.<br />
Ladics 1 and L. Burns-Naas 2 . 1 DuPont Co., Newark, DE<br />
and 2 Pfizer, Inc., San Diego, CA.<br />
94<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room RO2<br />
SUNSET SESSION: INTERVIEWING SKILLS FOR GRADUATE<br />
STUDENTS AND POST-DOCS<br />
Chairperson(s): Robert J. Mitkus, University <strong>of</strong> Maryland, Baltimore, MD<br />
and Melinda Pomeroy, Virginia-Maryland Regional College <strong>of</strong> Veterinary<br />
Medicine, Blacksburg, VA.<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room 220<br />
SUNSET SESSION: TEACHING UNDERGRADUATE TOXICOLOGY<br />
IN THE 21ST CENTURY<br />
Chairperson(s): Thomas W. Simmons, Indiana University <strong>of</strong> Pennsylvania,<br />
Indiana, PA and Joan B. Tarl<strong>of</strong>f, University <strong>of</strong> Sciences in Philadelphia,<br />
Philadelphia, PA.<br />
Endorsed by:<br />
Career Resource and Development Committee<br />
Education Committee<br />
National Capital Area Chapter*<br />
Student Advisory Committee<br />
The ability to interview well is a critical career skill, and keeping this skill upto-date<br />
is even more important in a volatile social and economic environment.<br />
Moreover, interviewing skills that are considered important in one sector <strong>of</strong> the<br />
job market may be quite different from those in another. Therefore, it is no<br />
surprise that there are substantial differences in the expectations <strong>of</strong> employers<br />
looking to fill positions in these two areas <strong>of</strong> post-graduate employment. The<br />
purpose <strong>of</strong> this session is to expand the personal skills sets <strong>of</strong> graduate students<br />
and post-docs with regard to interviewing for post-doctoral research positions at<br />
an academic institution, faculty positions at a community college or undergraduate<br />
institution, positions in the federal government, as well as positions in the<br />
private sector. This goal will be accomplished through formal presentations on<br />
interviewing skills, followed by question-and-answer sessions. An informed<br />
presentation on interview questions that are legally permissible across all hiring<br />
sectors is an essential part <strong>of</strong> this session. Because acquiring and processing<br />
knowledge <strong>of</strong> current interviewing skills and practices is a prerequisite for<br />
putting these skills into practice, this workshop is a must for all toxicologists<br />
who are making the transition into the workforce.<br />
#315 4:30 INTERVIEWING SKILLS FOR GRADUATE<br />
STUDENTS AND POST-DOCS. R. J. Mitkus 1 and M.<br />
Pomeroy-Black 2 . 1 Epidemiology and Preventive<br />
Medicine, University <strong>of</strong> Maryland, Baltimore, MD and<br />
2 Biomedical Sciences and Pathobiology, Virginia-<br />
Maryland Regional College <strong>of</strong> Veterinary Medicine,<br />
Blacksburg, VA.<br />
#316 4:32 INTERVIEWING FOR AN ACADEMIC POST-<br />
DOCTORAL POSITION. M. Ehrich. Biomedical<br />
Sciences and Pathobiology, Virginia-Maryland Regional<br />
College <strong>of</strong> Veterinary Medicine, Blacksburg, VA.<br />
#317 4:47 INTERVIEWING SKILLS FOR A TEACHING<br />
POSITION AT AN UNDERGRADUATE<br />
INSTITUTION. R. Resau. Biology, McDaniel College,<br />
Baltimore, MD. Sponsor: R. Mitkus.<br />
#318 5:02 INTERVIEWING SKILLS FOR A POSITION IN<br />
THE FEDERAL GOVERNMENT: AN<br />
INTERVIEWER’S PERSPECTIVE. R. J. Mitkus and<br />
A. C. Mosby. Office <strong>of</strong> Communications and<br />
Government Relations, U.S. EPA Region III,<br />
Philadelphia, PA. Sponsor: R. Mitkus.<br />
#319 5:17 INTERVIEWING SKILLS FOR A POSITION IN<br />
THE PRIVATE SECTOR. J. C. Lamb. The Weinberg<br />
Group, Washington, DC.<br />
#320 5:32 WHAT INTERVIEWERS CAN AND CANNOT<br />
ASK BY LAW. A. Mosby. OPM, U.S. EPA Region III,<br />
Philadelphia, PA. Sponsor: R. Mitkus.<br />
Endorsed by:<br />
Allegheny-Erie RC<br />
Education Committee*<br />
Mid-Atlantic RC<br />
Women in <strong>Toxicology</strong> SS<br />
Undergraduate toxicology course <strong>of</strong>ferings and teaching methods for delivering<br />
these courses have dramatically changed over the last twenty years. Historically,<br />
toxicology was a discipline that was more or less restricted to graduate and postdoctoral<br />
training. This emphasis was reflected by a symposium on Some Special<br />
<strong>Toxicology</strong> Education and Training <strong>Program</strong>s that was sponsored by the<br />
National Institute <strong>of</strong> Environmental Health Sciences in 1980. The idea <strong>of</strong> undergraduate<br />
toxicology <strong>of</strong>ferings was debated and discussed, and four Bachelor <strong>of</strong><br />
Science programs were highlighted at this workshop. In 1992 a follow-up forum<br />
on Undergraduate <strong>Toxicology</strong> Coursework was convened at a <strong>Society</strong> <strong>of</strong><br />
<strong>Toxicology</strong> annual meeting. The objective <strong>of</strong> this Forum was to reach a<br />
consensus on the content <strong>of</strong> a one-year course in toxicology to be <strong>of</strong>fered at the<br />
undergraduate level by colleges and universities. Interestingly, Dr. Donald Reed<br />
stated in his opening remarks that by the 21st century there could be tens <strong>of</strong><br />
thousands <strong>of</strong> undergraduate students taking toxicology. Although the number <strong>of</strong><br />
undergraduate students enrolled today in toxicology courses may not number in<br />
the tens <strong>of</strong> thousands, it is clear that a significant number <strong>of</strong> students are taking<br />
courses in major, minor and track toxicology programs. In addition, many more<br />
students are enrolled in courses <strong>of</strong>fered by non-toxicology/pharmacology degree<br />
programs. Along with this increase in toxicology course <strong>of</strong>ferings; topics,<br />
methods and tools for teaching toxicology have also grown. New technologies<br />
including s<strong>of</strong>tware programs and internet resources, current events including<br />
bio-terrorism, television programming such as Crime Scene Investigation, and<br />
new teaching strategies incorporating scientific inquiry, constructivism, and<br />
reflective practice are transforming the toxicology classroom. The goal <strong>of</strong> this<br />
workshop is to provide a forum to improve teaching and learning in the toxicological<br />
sciences, by sharing experiences related to these trends.<br />
#321 4:30 TEACHING UNDERGRADUATE TOXICOLOGY<br />
IN THE 21 ST CENTURY. T. W. Simmons 1 and J. B.<br />
Tarl<strong>of</strong>f 2 . 1 Department <strong>of</strong> Biology, Indiana University <strong>of</strong><br />
Pennsylvania, Indiana, PA and 2 Department <strong>of</strong><br />
Pharmaceutical Sciences, University <strong>of</strong> the Sciences in<br />
Philadelphia, Philadelphia, PA.<br />
#322 4:35 OVERVIEW OF UNDERGRADUATE COURSE<br />
OFFERINGS: TOXICOLOGY TEACHING<br />
PROJECT. T. W. Simmons. Department <strong>of</strong> Biology,<br />
Indiana University <strong>of</strong> Pennsylvania, Indiana, PA.<br />
#323 4:40 LABORATORY EXPERIENCES IN THE<br />
CLASSROOM. J. B. Tarl<strong>of</strong>f. Department <strong>of</strong><br />
Pharmaceutical Sciences, University <strong>of</strong> the Sciences in<br />
Philadelphia, Philadelphia, PA.<br />
#324 5:00 CURRENT EVENTS IN THE CLASSROOM. S. M.<br />
Ford. College <strong>of</strong> Pharmacy & Allied Health, Saint Johns<br />
University, Jamaica, NY.<br />
MONDAY<br />
up-to-date information at www.toxicology.org 95
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#325 5:20 LOBO PHARMACOKINETICS COMPUTER<br />
SOFTWARE: INTERACTIVE<br />
PHARMACOKINETIC MODELING. C. Marcus 1 ,<br />
D. Godwin 1 , E. Dan<strong>of</strong>f 1 and R. Galinsky 2 . 1 College <strong>of</strong><br />
Pharmacy, University New Mexico, Albuquerque, NM<br />
and 2 College <strong>of</strong> Pharmacy and Pharmacal Sciences,<br />
Purdue University, W. Lafayette, IN.<br />
#326 5:40 DISTANCE EDUCATION: ONLINE TEACHING<br />
OF TOXICOLOGY. K. L. Willett and A. Bouldin.<br />
Department <strong>of</strong> Pharmacology, University <strong>of</strong> Mississippi,<br />
University, MS.<br />
Abstract 327 is located on page 73.<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room 207<br />
CAREER RESOURCE AND DEVELOPMENT SEMINAR:<br />
CONSULTING AS A CAREER CHOICE<br />
Sponsored by:<br />
The Career Resource and Development Committee (formerly the<br />
Placement Committee)<br />
Chairperson(s): Tracy Williams, Eli Lilly & Company, Greenfield, IN and<br />
Barbara D. Beck, Gradient Corporation, Cambridge, MA.<br />
<strong>Toxicology</strong> consulting provides a unique employment option that can be tailored<br />
to an individual scientist’s educational and technical background. <strong>Toxicology</strong><br />
consultants may enjoy certain freedoms with respect to schedule, client relationships,<br />
and work environment, although client demands, market factors, and<br />
other elements can be limitations. <strong>Toxicology</strong> consultants are employed in every<br />
sector <strong>of</strong> toxicology including, but not limited to, consumer products, environmental,<br />
agriculture, chemical, and pharmaceutical industries, litigation support,<br />
risk assessment and product safety. Prior to embarking on this career path it is<br />
wise to appreciate the advantages and disadvantages <strong>of</strong> consulting and understand<br />
what consulting is all about. In this session, participants will learn about<br />
life as a toxicology consultant, choosing to operate as a sole practitioner versus<br />
joining a company, starting a consulting business, consulting following retirement,<br />
and Internet-based and other tools to increase your visibility and client<br />
portfolio.<br />
• Consulting Overview, Tracy Williams, Eli Lilly and Company, Greenfield,<br />
IN.<br />
• Life <strong>of</strong> a Consultant, Barbara D. Beck, Gradient Corporation, Cambridge,<br />
MA.<br />
• Starting a Consulting Company, Rosalind School, Integral Consulting<br />
Inc, Mercer Island, WA.<br />
• Virtual Consulting Tools and Opportunities, Dennis Hoover, Eli Lilly<br />
and Company, Greenfield, IN.<br />
Monday Afternoon, March 7<br />
4:30 PM to 6:00 PM<br />
Room 223<br />
SPECIALTY SECTION PRESIDENTS’AND OFFICERS’ MEETING<br />
Monday Evening, March 7<br />
6:00 PM to 6:30 PM<br />
Room RO2<br />
Monday Evening<br />
UNDERGRADUATE TOXICOLOGY TEACHING FORUM<br />
Chairperson(s): Thomas Simmons, Indiana University <strong>of</strong> Pennsylvania,<br />
Indiana, PA.<br />
Sponsored by:<br />
Education Committee<br />
Allegheny-Erie Regional Chapter<br />
All those interested in undergraduate education are invited to attend this session.<br />
The meeting will continue the discussion from the Sunset Workshop, and<br />
develop a formal structure for continuing the group. Other future activities will<br />
be discussed as time permits.<br />
Monday Evening, March 7<br />
6:00 PM to 7:30 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
SPECIALTY SECTION MEETINGS:<br />
ETHICAL, LEGAL AND SOCIAL ISSUES, IMMUNOTOXICOLOGY,<br />
MECHANISMS, OCCUPATIONAL AND PUBLIC HEALTH, RISK<br />
ASSESSMENT, TOXICOLOGIC AND EXPLORATORY PATHOLOGY<br />
Monday Evening, March 7<br />
6:00 PM to 11:00 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
REGIONAL CHAPTER MEETINGS/RECEPTIONS<br />
Many <strong>of</strong> the Regional Chapters meet during the SOT Annual Meeting. Details<br />
for these Regional Chapter receptions and meetings are listed in <strong>Program</strong>’s<br />
Events Calendar.<br />
96<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
7:00 AM to 8:30 AM<br />
Room 225<br />
Tuesday Morning<br />
REGIONAL CHAPTER PRESIDENTS’AND OFFICERS’ MEETING<br />
Tuesday Morning, March 8<br />
7:00 AM to 7:45 AM<br />
RO1<br />
SUNRISE SESSION: TOXIC TORTS: TOXICOLOGISTS IN THE<br />
COURTROOM<br />
Chairperson(s): Richard Parent, Consultox, Ltd.,, Damariscotta, ME and<br />
Willie J. McKinney, Philip Morris, USA, Richmond, VA.<br />
Endorsed by:<br />
Career Resource and Development Committee*<br />
Ethical Legal and Social Issues SS<br />
Regulatory and Safety Evaluation SS<br />
Student Advisory Committee<br />
Litigation involving exposure to chemicals is on the rise in the United States.<br />
This has created a new role for toxicologists. Toxicologists are <strong>of</strong>ten called upon<br />
to provide testimony (e.g. expert, fact) in a variety <strong>of</strong> legal situations (e.g. court,<br />
deposition, hearings, state, federal, defense, and plaintiff). However, explaining<br />
extremely complex and sometimes controversial scientific concepts and data to<br />
a non-scientist (e.g. judges, juries) can be challenging. Therefore, knowledge <strong>of</strong><br />
skills necessary for effective clear testimony, attorney/client expectations, and<br />
potential ethical conflicts are critical prior to entering the court room. In addition,<br />
a toxicologist called upon to provide litigation support should be aware <strong>of</strong><br />
the potential positive and negative career impacts. This sunrise session will<br />
provide a forum to discuss issues a scientist functioning as an expert witness<br />
may encounter as well as give information that will be valuable for scientist<br />
called upon for expert testimony.<br />
#635 7:00 TOXIC TORTS: TOXICOLOGISTS IN THE<br />
COURTROOM. W. J. McKinney 1 , R. Parent 2 , R. G.<br />
Smith 3 and A. R. Brody 4 . 1 Philip Morris USA,<br />
Richmond, VA, 2 Consultox, Damariscotta, ME,<br />
3 4 Venable LLP, Baltimore, MD and Pathology and<br />
Laboratory Medicine, Tulane University Health<br />
Sciences Center, New Orleans, LA.<br />
Tuesday Morning, March 8<br />
7:15 AM to 8:15 AM<br />
Room RO6<br />
TOWN HALL MEETING: NIH-MANDATED PUBLIC ACCESS TO<br />
SPONSORED RESEARCH PUBLICATIONS: IMPACT ON<br />
TOXICOLOGICAL SCIENCES<br />
Presiding: Lois Lehman-McKeeman, Editor <strong>of</strong> Toxicological Sciences and<br />
Richard Peterson, Chair <strong>of</strong> the Board <strong>of</strong> Publications.<br />
Lois Lehman-McKeeman, Editor <strong>of</strong> Toxicological Sciences, and Richard<br />
Peterson, Chair <strong>of</strong> the Board <strong>of</strong> Publications, will share their perspectives on the<br />
potential consequences <strong>of</strong> new policies mandating open access to NIHsponsored<br />
research on the future <strong>of</strong> our Journal.<br />
Tuesday Morning, March 8<br />
8:00 AM to 4:30 PM<br />
Room 213<br />
PARACELSUS GOES TO SCHOOL TEACHER WORKSHOP<br />
Chairperson(s): Kenneth McMartin, Louisiana State University Health<br />
Science Center, Shreveport, LA and Mark Reasor, West Virginia University,<br />
Morgantown, WV.<br />
Sponsored by:<br />
The Education Committee<br />
The Education Subcommittee for K–12 Education<br />
This special program will be <strong>of</strong>fered for local educators teaching grades K–12<br />
and for interested SOT members. The main goal <strong>of</strong> the program is to enhance<br />
science education by stimulating ideas for incorporating multidisciplinary toxicology<br />
and environmental health science concepts and teaching materials into<br />
classrooms. Lectures and interactive workshops will be tailored to the needs <strong>of</strong><br />
different grade levels. New Orleans area toxicologists will serve as Science<br />
Partners to continue the effort in local classrooms.<br />
7:15 AM–7:45 AM Registration<br />
8:00 AM–8:15 AM Opening and Welcome<br />
Kenneth McMartin, Local Chair, LSU Health<br />
Science Center, Shreveport, LA.<br />
Linda Birnbaum, SOT President, U.S. EPA,<br />
Research Triangle Park, NC.<br />
8:15 AM–8:35 AM The Diversity that is <strong>Toxicology</strong><br />
Harihara Mehendale, University <strong>of</strong> Louisiana at<br />
Monroe, Monroe, LA.<br />
8:35 AM–9:05 AM Overview <strong>of</strong> Local Toxicological Issues in<br />
Louisiana<br />
Charles Miller, Tulane University, New Orleans,<br />
LA.<br />
Steve Pruett, LSU Health Science Center,<br />
Shreveport, LA<br />
9:05 AM–9:15 AM Issues Surrounding the Use <strong>of</strong> Animals in<br />
Toxicological Research<br />
Joanne Zurlo, NAS Institute <strong>of</strong> Laboratory Animal<br />
Science, Washington, DC.<br />
9:15 AM–11: 45 AM Workshops Session I<br />
K–4—My Health My World (Room 211)<br />
Barbara Tharp and Nancy Moreno, Baylor College<br />
<strong>of</strong> Medicine, Houston, TX.<br />
4–8—What Students Need to Know About Diet,<br />
Sun Exposure, and Tobacco Use (Room 212)<br />
Jennifer Gorenstein and Donna Meyer, University<br />
<strong>of</strong> Texas MD Anderson Cancer Center, Smithville,<br />
TX.<br />
9–12—Risk Assessment Case Study (Room 214)<br />
Suzanne Fitzpatrick, U.S. FDA, Rockville, MD<br />
and Joseph Rodericks, ENVIRON Corporation,<br />
Arlington, VA.<br />
11:45 AM–1:15 PM Lunch for Teachers and <strong>Toxicology</strong> Science<br />
Partners (break out rooms)<br />
Education Poster Session<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 97
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
1:15 PM–2:45 PM Workshop Session II (break out rooms)<br />
2:45 PM–3:15 PM Paracelsus in Practice (Room 213)<br />
Moderator: David Cragin, Merck and Company,<br />
Inc., Whitehouse Station, NJ.<br />
3:15 PM–3:30 PM <strong>Program</strong> Conclusion and Evaluation<br />
Kenneth McMartin, LSU Health Science Center,<br />
Shreveport, LA.<br />
3:30 PM–4:30 PM Visit ToxExpo<br />
Tuesday Morning, March 8<br />
8:30 AM to 9:30 AM<br />
Room 223<br />
INFORMATIONAL SESSION: THE ROSETTA RESOLVER®<br />
SYSTEM: AN ENTERPRISE SOLUTION FOR GENE EXPRESSION<br />
ANALYSIS AND PREDICTIVE TOXICOLOGY<br />
The Rosetta Resolver® System, an enterprise gene expression analysis solution,<br />
is a cornerstone in drug discovery for routinely processing and managing data<br />
from thousands <strong>of</strong> high-density microarrays. This presentation will focus on the<br />
current challenges <strong>of</strong> toxicogenomics data analysis in drug development, and<br />
how the use <strong>of</strong> the Resolver system addresses those challenges.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO2<br />
SYMPOSIUM SESSION: ALTERED IRON HOMEOSTASIS (AIH) AS A<br />
BASIS FOR PULMONARY IMMUNOTOXICOLOGIC EFFECTS OF<br />
PARTICULATE MATTER<br />
Chairperson(s): Mitch Cohen, New York University School <strong>of</strong> Medicine,<br />
Tuxedo, NY and Andrew Ghio, National Health & Environmental Effect<br />
Research Laboratory, Chapel Hill, NC.<br />
Endorsed by:<br />
Immunotoxicology SS*<br />
Inhalation Specialty Section<br />
Student Advisory Committee<br />
The scientific literature is replete with reports on the pulmonary toxicologic and<br />
immuno-toxicologic effects <strong>of</strong> particulate matter (PM). Although it has become<br />
increasingly accepted that the composition <strong>of</strong> PM is a major factor influencing<br />
biological effects, mechanisms to describe how composition might induce<br />
observed toxicities are mostly lacking. The altered iron homeostasis (AIH)<br />
theory postulates that specific components in PM induce alterations in the levels<br />
<strong>of</strong> free catalytically-active iron within the lungs as well as in iron availability to<br />
both lung epithelial and immune cells. These changes, in turn, impact upon local<br />
responses to infectious agents and allergens, as well as upon the release <strong>of</strong> cell<br />
products that might contribute to cardiopulmonary changes. The AIH theory not<br />
only provides a basis to explain how select PM constituents might induce these<br />
effects, but also how day-to-day or regional differences in the amounts <strong>of</strong> these<br />
components (relative to that <strong>of</strong> iron) may underlie the variability in reported<br />
health effects induced with equivalent doses <strong>of</strong> differing PM samples. Following<br />
introductory talks about the role <strong>of</strong> iron homeostasis in maintenance <strong>of</strong> immune<br />
cell functions and how components <strong>of</strong> PM may be selectively mobilized, this<br />
symposium will highlight specifically how AIH could be the basis for the<br />
observed alterations in allergic, immunologic, and cardiopulmonary responses<br />
after host exposures to PM.<br />
#636 8:30 ALTERED IRON HOMEOSTASIS (AIH) AS A<br />
BASIS FOR PULMONARY<br />
IMMUNOTOXICOLOGIC EFFECTS OF<br />
PARTICULATE MATTER. M. Cohen. Environmental<br />
Medicine, New York University, Tuxedo, NY.<br />
#637 8:35 THE ROLE OF IRON (FE) HOMEOSTASIS IN<br />
IMMUNE CELL FUNCTIONALITY. C. L. Bowlus.<br />
Department <strong>of</strong> Internal Medicine, University <strong>of</strong><br />
California Davis Medical Center, Sacramento, CA.<br />
Sponsor: M. Cohen.<br />
#638 9:10 MOBILIZATION OF METALS FROM<br />
PARTICLES: IMMUNOTOXICOLOGIC<br />
IMPLICATIONS. A. E. Aust. Department <strong>of</strong><br />
Chemistry and Biochemistry, Utah State University,<br />
Logan, UT.<br />
#639 9:45 METALS, PARTICLES AND IMPACT UPON<br />
PULMONARY ALLERGIC RESPONSES. M.<br />
Gilmour. National Health and Environmental Effects<br />
Research Laboratory, U.S. EPA, Research Triangle<br />
Park, Durham, NC.<br />
#640 10:20 EFFECTS OF PARTICLES ON FE TRANSPORT<br />
AND THE IMMUNOTOXICOLOGIC<br />
OUTCOMES. A. J. Ghio. National Health and<br />
Environmental Effects Research Laboratory, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#641 10:55 DO ALTERED FE STATUS-INDUCED EFFECTS<br />
ON TRANSCRIPTION FACTORS HAVE A ROLE<br />
IN PM-INDUCED<br />
PULMONARY/CARDIOVASCULAR DISEASES?<br />
K. Salnikow. Laboratory <strong>of</strong> Comparative<br />
Carcinogenesis, National Cancer Institute, Frederick,<br />
MD.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room 208<br />
SYMPOSIUM SESSION: BEYOND LIVER TOXICOGENOMICS:<br />
GENE EXPRESSION BASED BIOMARKERS IN NON-HEPATIC<br />
TISSUES<br />
Chairperson(s): Kyle Kolaja, Iconix, Mountain View, CA and David J. Dix,<br />
National Health & Environmental Effects Research Laboratory, Research<br />
Triangle Park, NC.<br />
Endorsed by:<br />
Carcinogenesis SS<br />
Toxicologic and Exploratory Pathology SS<br />
Toxicogenomics, the genome scale analysis <strong>of</strong> chemically induced changes in<br />
complex populations <strong>of</strong> mRNA to understand toxicity, has already dramatically<br />
impacted predictive and mechanistic toxicology. Gene expression based<br />
biomarkers can provide a precise and rapid assessment <strong>of</strong> toxicity or exposure,<br />
but most toxicogenomics efforts to date have been conducted in liver due to toxicological<br />
interest, technical ease <strong>of</strong> data creation, relative homogeneity <strong>of</strong> tissue<br />
sample, and historical inertia. Recently analysis <strong>of</strong> gene expression data in nonhepatic<br />
organs and tissues has started to gain momentum, and this session will<br />
include presentations <strong>of</strong> significant and promising examples ranging from toxicogenomic<br />
analyses <strong>of</strong> vascular, cardiac, kidney, neural and reproductive tissues<br />
treated with various drugs, chemicals, and toxicants. From these burgeoning<br />
studies, researchers are identifying biomarkers predictive <strong>of</strong> toxicity and indicative<br />
<strong>of</strong> various mechanisms and pharmacology in non-hepatic tissues.<br />
#642 8:30 BEYOND LIVER TOXICOGENOMICS: GENE<br />
EXPRESSION BASED BIOMARKERS IN NON-<br />
HEPATIC TISSUES. K. L. Kolaja. <strong>Toxicology</strong>, Iconix<br />
Pharmaceuticals, Mountain View, CA.<br />
98<br />
SOT’s 44 th Annual Meeting
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<strong>Program</strong> Description<br />
#643 8:35 MEASURING GENE EXPRESSION IN BLOOD<br />
VESSELS: THE CHALLENGES OF APPLYING<br />
TOXICOGENOMICS TO VASCULITIS. M. P.<br />
Lawton. Molecular and Investigative <strong>Toxicology</strong>, Pfizer,<br />
Inc., Groton, CT.<br />
#644 9:10 GENE EXPRESSION PROFILING TO IDENTIFY<br />
BIOMARKERS OF REPRODUCTIVE TOXICITY.<br />
D. J. Dix. Office <strong>of</strong> Research and Development, U.S.<br />
EPA, Research Triangle Park, NC.<br />
#645 9:45 EXPOSURE-INDUCED NEURODEGENERATION:<br />
A TOXICOGENOMICS CASE STUDY OF<br />
NEURONAL FUNCTION AND<br />
NEURODEGENERATIVE DISEASE. A. Brooks 1,2 ,<br />
D. Cory-Slechta 3 , E. Richfeild 3 and M. Thiruchelvam 3 .<br />
1 Environmental Medicine, Univeristy <strong>of</strong> Rochester<br />
Medical Center, Rochester, NY, 2 Functional Genomics<br />
Center, Univeristy <strong>of</strong> Rochester Medical Center,<br />
Rochester, NY and 3 Environmental and Occupational<br />
Medicine, UMDNJ, Piscataway, NJ.<br />
#646 10:20 GENE EXPRESSION-BASED BIOMARKERS OF<br />
CARDIAC AND RENAL PHARMACO- AND<br />
TOXICOGENOMICS. K. L. Kolaja. Chemogenomics<br />
and <strong>Toxicology</strong>, Iconix Pharmaceuticals, Mountain<br />
View, CA.<br />
#647 10:55 APPLICATION OF TOXICOGENOMICS<br />
BEYOND LIVER. Y. Yang, R. Ciurlionis, S. J. Abel, E.<br />
A. Blomme and J. F. Waring. R463, Abbott<br />
Laboratories, Abbott Park, IL.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
SYMPOSIUM SESSION: EMERGING ISSUES IN RISK ASSESSMENT<br />
AND RISK PERCEPTION OF NANOMATERIALS<br />
Chairperson(s): Joyce S. Tsuji, Exponent Environmental Group Inc.,<br />
Bellevue, WA and Annette B. Santamaria, Exponent, Houston, TX.<br />
Endorsed by:<br />
Inhalation SS<br />
Risk Assessment SS*<br />
Nanotechnology has been hailed as the new industrial revolution akin to silicon<br />
chip development in the last century. Nanomaterials are generally
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#653 10:45 RISK ASSESSMENT AND SAFETY EVALUATION<br />
OF NANOMATERIALS IN CONSUMER<br />
PRODUCTS. A. B. Santamaria 1 and N. J. Rachman 2 .<br />
1 2 Health Risk, Exponent, Houston, TX and Food and<br />
Chemicals, Exponent, Washington, DC.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO6<br />
SYMPOSIUM SESSION: NUCLEOCYTOPLASMIC TRAFFICKING<br />
IN MECHANISMS OF TOXICITY<br />
Chairperson(s): Walter Watson, Johns Hopkins Bloomberg School <strong>of</strong> Public<br />
Health, Baltimore, MD and Richard Pollenz, University <strong>of</strong> South Florida,<br />
Tampa, FL.<br />
Endorsed by:<br />
Mechanisms SS*<br />
Molecular Biology SS<br />
Student Advisory Committee<br />
#659 10:50 TOXICANT-INDUCED NUCLEAR<br />
TRANSLOCATION OF THIOREDOXIN. W. H.<br />
Watson. Environmental Health Sciences, Johns Hopkins<br />
Bloomberg School <strong>of</strong> Public Health, Baltimore, MD.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO3<br />
WORKSHOP SESSION: CURRENT STATUS AND FUTURE<br />
CONSIDERATIONS FOR THE DEVELOPMENT AND VALIDATION<br />
OF IN VITRO ALTERNATIVES TO THE DRAIZE RABBIT EYE TEST<br />
Chairperson(s): William Stokes, National Institute <strong>of</strong> Environmental Health<br />
Sciences, Research Triangle Park, NC.<br />
Endorsed by:<br />
In Vitro SS*<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
TUESDAY<br />
Transport <strong>of</strong> proteins across the nuclear membrane is tightly regulated by the<br />
nuclear pore, a multisubunit complex consisting <strong>of</strong> at least 30 proteins. There<br />
are few known examples <strong>of</strong> toxins or toxicants that act directly at the nuclear<br />
pore to affect transport. However, import or export <strong>of</strong> specific proteins is a key<br />
component <strong>of</strong> cellular responses to a variety <strong>of</strong> toxicants. For example, many<br />
transcription factors are maintained as inactive cytoplasmic pools that can<br />
rapidly translocate to the nucleus upon exposure to toxicants and other stimuli.<br />
Interactions that anchor proteins in either compartment or target proteins to the<br />
nuclear pore may be disrupted (or enhanced) by toxicants or by specific posttranslational<br />
modifications such as phosphorylation or SUMO modification. An<br />
understanding <strong>of</strong> the factors that control the dynamic localization <strong>of</strong> proteins<br />
across the nuclear membrane is necessary for the definition <strong>of</strong> toxicological<br />
mechanisms and physiological pathways.<br />
#654 8:30 NUCLEOCYTOPLASMIC TRAFFICKING IN<br />
MECHANISMS OF TOXICITY. W. H. Watson 1 and<br />
G. H. Perdew 2 . 1 Environmental Health Sciences, Johns<br />
Hopkins Bloomberg School <strong>of</strong> Public Health,<br />
Baltimore, MD and 2 Center for Molecular <strong>Toxicology</strong>,<br />
Penn State University, University Park, PA.<br />
#655 8:30 NUCLEOCYTOPLASMIC TRAFFICKING IN<br />
MECHANISMS OF TOXICITY. W. H. Watson.<br />
Environmental Health Sciences, Johns Hopkins<br />
Bloomberg School <strong>of</strong> Public Health, Baltimore, MD.<br />
#656 8:35 NUCLEAR PROTEIN TRANSPORT: A ROLE IN<br />
REGULATING CELLULAR RESPONSES TO<br />
STIMULI. A. H. Corbett, M. T. Harreman, T. M. Kline<br />
and A. E. Hodel. Biochemistry, Emory University<br />
School <strong>of</strong> Medicine, Atlanta, GA. Sponsor: W. Watson.<br />
#657 9:20 SPECIES-DEPENDENT DIFFERENCES IN AH<br />
RECEPTOR NUCLEOCYTOPLASMIC<br />
SHUTTLING PROPERTIES. G. Perdew, P.<br />
Ramadoss and B. D. Hollingshead. Center for<br />
Molecular <strong>Toxicology</strong> and Carcinogenesis and<br />
Department <strong>of</strong> Veterinary Science, The Pennsylvania<br />
State University, University Park, PA.<br />
#658 10:05 SUMO MODIFICATION AND REGULATION OF<br />
NUCLEAR TRANSPORT. M. J. Matunis and H.<br />
Zhang. Biochemistry and Molecular Biology, Johns<br />
Hopkins University, Baltimore, MD. Sponsor: W.<br />
Watson.<br />
The Draize rabbit eye test has been used as the standard test method for<br />
assessing ocular irritation and corrosivity potential <strong>of</strong> chemicals and products<br />
for over 60 years. Largely due to the pain and discomfort associated with this<br />
test, there have been extensive efforts to develop and validate alternative test<br />
methods that would partially or fully replace the current regulatory version <strong>of</strong><br />
the Draize rabbit eye test. These efforts are also being driven by the 7th<br />
Amendment to the European Union Cosmetics Directive that will ban the use <strong>of</strong><br />
animals for ocular testing by 2009 and pressure to minimize or avoid animal use<br />
for the European Union Chemicals Policy Initiative (REACH). This workshop<br />
will address scientific and regulatory considerations for developing and validating<br />
in vitro test methods that will refine, reduce, and replace the Draize rabbit<br />
eye test. ICCVAM, NICEATM, and ECVAM have recently initiated collaborations<br />
to assess the usefulness <strong>of</strong> currently available in vitro ocular toxicity<br />
methods and to review the state-<strong>of</strong>-the-science with regard to in vitro test<br />
methods. These efforts include an evaluation <strong>of</strong> several in vitro test methods for<br />
their ability to detect severe ocular irritants, an assessment <strong>of</strong> the performance<br />
characteristics <strong>of</strong> the in vivo rabbit eye test, and a review <strong>of</strong> the current status <strong>of</strong><br />
methods for identifying nonirritants and mild to moderate irritants. Current and<br />
future challenges in validating alternative methods and approaches to evaluate<br />
ocular toxicity will be presented including the need for high quality reference<br />
data to assess test method performance.<br />
#660 8:30 CURRENT STATUS AND FUTURE<br />
CONSIDERATIONS FOR THE DEVELOPMENT<br />
OF IN VITRO ALTERNATIVES TO THE DRAIZE<br />
RABBIT EYE TEST FOR ASSESSING OCULAR<br />
IRRITANTS. T. Hartung 1 and W. S. Stokes 2 . 1 ECVAM,<br />
Ispra, Italy and 2 NICEATM, NIEHS/NIH/DHHS,<br />
Research Triangle Park, NC.<br />
#661 8:40 CURRENT STATUS AND FUTURE<br />
CONSIDERATIONS FOR ALTERNATIVE<br />
METHODS TO REFINE, REDUCE, AND<br />
REPLACE ANIMAL USE FOR OCULAR SAFETY<br />
TESTING. W. S. Stokes. NICEATM,<br />
NIEHS/NIH/DHHS, Research Triangle Park, NC.<br />
#662 9:10 THE PERFORMANCE CHARACTERISTICS OF<br />
THE IN VIVO RABBIT EYE TEST. J. H. Haseman 1 ,<br />
N. Y. Choksi 2,3 , C. Inh<strong>of</strong> 2,3 , J. Truax 2,3 , R. R. Tice 2,3 and<br />
W. S. Stokes 3 . 1 Consultant, NIEHS/NIH/DHHS,<br />
Research Triangle Park, NC, 2 ILS, Inc., Research<br />
Triangle Park, NC and 3 NICEATM,<br />
NIEHS/NIH/DHHS, Research Triangle Park, NC.<br />
100<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#663 9:40 PERFORMANCE OF BCOP, IRE, ICE, AND HET-<br />
CAM IN DETECTING SUBSTANCES THAT<br />
INDUCE SEVERE IRRITATION AND<br />
IRREVERSIBLE OCULAR DAMAGE. N. Y.<br />
Choksi 1,2 , D. A. Allen 1,2 , C. Inh<strong>of</strong> 1,2 , J. Truax 1,2 , R. R.<br />
Tice 1,2 and W. S. Stokes 2 . 1 ILS, Inc., Research Triangle<br />
Park, NC and 2 NICEATM, NIEHS/NIH/DHHS,<br />
Research Triangle Park, NC.<br />
#664 10:10 THE STATE OF THE SCIENCE ON IN VITRO<br />
TEST METHODS FOR DETECTING MILD TO<br />
MODERATE OCULAR IRRITANTS. C. Eskes, T.<br />
Hartung and V. Zuang. ECVAM, IHCP, European<br />
Commission–DG JRC, Ispra, Varese, Italy. Sponsor: W.<br />
Stokes.<br />
#665 10:40 CHALLENGES IN THE VALIDATION OF<br />
ALTERNATIVE TEST METHODS TO EVALUATE<br />
OCULAR TOXICITY. T. Hartung, C. Eskes and V.<br />
Zuang. European Centre for the Validation <strong>of</strong><br />
Alternative Methods, European Commission DG JRC,<br />
Ispra, Varese, Italy. Sponsor: W. Stokes.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO4<br />
WORKSHOP SESSION: MODE OF ACTION IN RELEVANCE OF<br />
RODENT LIVER TUMORS TO HUMAN CANCER RISK<br />
Chairperson(s): Yvonne Dragan, National Center for Toxicological Research,<br />
Jefferson, AR and Michael Holsapple, International Life Sciences Institute,<br />
Washington, DC.<br />
Endorsed by:<br />
Carcinogenesis SS*<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
The recent adoption <strong>of</strong> the IPCS mode <strong>of</strong> action paradigm (Sonich-Mullin et al.,<br />
2001, Regul Toxicol Pharmacol 34:146-152) coupled with the recent ILSI<br />
human relevance framework (Cohen et al., 2003, Crit Rev Toxicol 33:581-589)<br />
have led to an approach for the systematic analysis <strong>of</strong> data on modes <strong>of</strong> carcinogenic<br />
action <strong>of</strong> chemicals in experimental animals and its application to the<br />
assessment <strong>of</strong> human cancer risk assessment. Hazard identification and risk<br />
assessment paradigms depend on the presumption <strong>of</strong> similarity <strong>of</strong> rodents to<br />
humans, yet species-specific responses and high dose to low dose extrapolation<br />
plague the development <strong>of</strong> appropriate risk assessments. The first step in a mode<br />
<strong>of</strong> action analysis is to establish the key biochemical and cellular events,<br />
temporal occurrence, and dose response concordance relationships common to<br />
each mode <strong>of</strong> action <strong>of</strong> a chemical. The next step is to assess the biological plausibility<br />
and relevance to human cancer risk <strong>of</strong> the proposed mode(s) <strong>of</strong> action<br />
taking kinetic and dynamic factors into consideration. The identification <strong>of</strong> key<br />
events can be used to bridge species and dose differences. These discussions<br />
will be used to generate a minimal dataset necessary to establish selected modes<br />
<strong>of</strong> action. This mode <strong>of</strong> action framework has been previously applied to rodent<br />
liver tumors associated with exposure to peroxisome proliferators mediated<br />
through the alpha receptor (Klaunig et al., 2003, Crit Rev Toxicol 33:655-780).<br />
More recently, several additional modes <strong>of</strong> action for rodent liver cancer development<br />
have been described including cytotoxicity, P450 induction, hormone<br />
mediated and porphyrogenicity / metal overload. An understanding <strong>of</strong> the mode<br />
<strong>of</strong> action underlying cancer development in the liver will place rodent liver<br />
tumors into a more appropriate perspective when human risk assessment is<br />
performed.<br />
#666 8:30 MODE OF ACTION IN RELEVANCE OF<br />
RODENT LIVER TUMORS TO HUMAN CANCER<br />
RISK. M. P. Holsapple 1 and Y. P. Dragan 2 . 1 HESI,<br />
Washington, DC and 2 NCTR, Jefferson, AR.<br />
#667 8:35 THE PATHOGENESIS OF RODENT<br />
HEPATOCARCINOGENESIS: POTENTIAL<br />
APPLICATIONS TO HUMAN CANCER RISK. H.<br />
C. Pitot. Oncology, McArdle Lab., University <strong>of</strong><br />
Wisconsin, Madison, WI.<br />
#668 9:05 FRAMEWORK FOR EVALUATING THE HUMAN<br />
RELEVANCE OF CARCINOGENIC MODES OF<br />
ACTION IN ANIMALS. S. M. Cohen. Pathology and<br />
Microbiology, University <strong>of</strong> Nebraska Medical Center,<br />
Omaha, NE.<br />
#669 9:35 MODE OF ACTION AND HUMAN RELEVANCE<br />
OF PHENOBARBITAL-LIKE RODENT LIVER<br />
CARCINOGENS. A. R. Boobis 1 , B. G. Lake 2 , E.<br />
Harpur 3 , J. M. Rice 4 and J. I. Goodman 5 . 1 Experimental<br />
Medicine and <strong>Toxicology</strong>, Imperial College London,<br />
London, United Kingdom, 2 BIBRA International Ltd.,<br />
Carshalton, United Kingdom, 3 San<strong>of</strong>i-Synthelabo,<br />
Malvern, PA, 4 Georgetown University, Washington, DC<br />
and 5 Michigan State University, East Lansing, MI.<br />
#670 9:55 MODE OF ACTION AND HUMAN RELEVANCE<br />
OF METAL OVERLOAD AND<br />
PORPHYRINOGENIC COMPOUNDS. J. E.<br />
Klaunig 1 , A. Nyska 2 , J. Popp 3 , A. Smith 4 , W. Stott 5 and<br />
G. Williams 6 . 1 Indiana University, Indianapolis, IN,<br />
2 3 NIEHS/NTP, Research Triangle Park, NC, Purdue<br />
Pharmacology, New York, 4 MRC <strong>Toxicology</strong>,<br />
University <strong>of</strong> Leicester, United Kingdom, 5 The Dow<br />
Chemical Company, Midland, MI and 6 New York<br />
Medical College, Valhalla, NY.<br />
#671 10:15 HORMONAL PERTURBATION AS A MODE OF<br />
ACTION FOR RODENT LIVER TUMORS. T.<br />
Pastoor 4 , Y. Dragan 1 , M. Cunningham 3 , I. White 7 , J.<br />
Teeguarden 6 , H. Pitot, III 5 and C. Capen 2 . 1 NCTR,<br />
Jefferson, AR, 2 Ohio State University, Columbus, OH,<br />
3 NIH/National Center for Toxicogenomics, Research<br />
Triangle Park, NC, 4 Syngenta CropScience, Greenboro,<br />
NC, 5 University <strong>of</strong> Wisconsin, Madison, WI,<br />
6 ENVIRON Corporation, Collegeville, PA and<br />
7 University <strong>of</strong> Leicester, Leicester, United Kingdom.<br />
#672 10:35 RODENT HEPATIC TUMORS: CYTOXICITY<br />
MODE OF ACTION. V. L. Dellarco 1 , S. Cohen 2 , D.<br />
Wolf 3 , R. Maronpot 4 and D. Jacobson-Kram 5 . 1 Office <strong>of</strong><br />
Pesticide <strong>Program</strong>s, U.S. EPA, Washington, DC,<br />
2 University <strong>of</strong> Nebraska Medical Center, Omaha, NE,<br />
3 Health and Environmental Effects Research<br />
Laboratory, U.S. EPA, Research Triangle Park, NC,<br />
4 NIEHS, National <strong>Toxicology</strong> <strong>Program</strong>, Research<br />
Triangle Park, NC and 5 CDER, U.S. FDA, Rockville,<br />
MD.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 101
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO1<br />
WORKSHOP SESSION: NEUROIMAGING STRATEGIES FOR<br />
APPLICATION TO NEUROTOXICOLOGY AND RISK ASSESSMENT<br />
Chairperson(s): William Slikker, Jr., National Center for Toxicological<br />
Research, Jefferson, AR and Tomas Guilarte, Johns Hopkins, Baltimore, MD.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
Neurotoxicology SS*<br />
Regulatory and Safety Evaluation SS<br />
Student Advisory Committee<br />
#678 10:55 EARLY BIOMARKERS OF PARKINSON’S<br />
DISEASE AS DEFINED BY POSITRON<br />
EMISSION TOMOGRAPHY. T. R. Guilarte 1 , M. K.<br />
Chen 1 , H. Kuwabara 2 , J. L. McGlothan 1 , M.<br />
Alexander 2 , J. R. Brasic 2 , R. J. Adams 3 and D. F.<br />
Wong 1,2 . 1 Department Environmental Health Sciences,<br />
Johns Hopkins Un, Baltimore, MD, 2 Department<br />
Radiology, Johns Hopkins University, Baltimore, MD<br />
and 3 Department Comparative Med., Johns Hopkins<br />
University, Baltimore, MD.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room 207<br />
TUESDAY<br />
Recent technological innovations now make it possible to apply many in vivo<br />
neuroimaging technologies such as positron emission tomography (PET) and<br />
magnetic resonance imaging (MRI) to small animals, including nonhuman<br />
primates, rats and mice. The availability <strong>of</strong> these new technologies coincides<br />
with progress in developing animal models <strong>of</strong> various developmental and<br />
neurodegenerative diseases and improvements in assessment protocols for identifying<br />
deficits in animals that correlate well with human deficits. The<br />
integration <strong>of</strong> neuroimaging techniques with traditional neurotoxicological<br />
assessments has the potential to enhance greatly the ability to relate behavioral,<br />
cognitive or motor dysfunction induced by a toxicant to structural and functional<br />
brain pathology. Changes in anatomy <strong>of</strong> s<strong>of</strong>t and hard tissue, metabolism and<br />
gene expression can now be done in both a preclinical and a clinical setting<br />
using such technologies as Magnetic Resonance Imaging (MRI), Magnetic<br />
Resonance Spectroscopy (MRS), Positron Emission Tomography (PET),<br />
Computer Tomography Scanning (CT scan) and Visible and Infrared Spectral<br />
Imaging. This permits longitudinal studies <strong>of</strong> the same subject subsequently<br />
reducing the number <strong>of</strong> animals required for studies while providing definitive<br />
information as a basis <strong>of</strong> risk assessment. This workshop will be <strong>of</strong> interest to<br />
toxicologists in general and in particular to neurotoxicologists and risk assessors.<br />
#673 8:30 NEUROIMAGING STRATEGIES FOR<br />
APPLICATION TO NEUROTOXICOLOGY AND<br />
RISK ASSESSMENT. W. Slikker 1 and T. R. Guilarte 2 .<br />
1 Division <strong>of</strong> Neurotoxicology, NCTR/FDA, Jefferson,<br />
AR and 2 Department <strong>of</strong> Environmental Health Sciences,<br />
Johns Hopkins Medical Institutions, Baltimore, MD.<br />
#674 8:35 NEUROIMAGING: NEW APPROACHES FOR<br />
NEUROTOXICOLOGY. W. Slikker. Division <strong>of</strong><br />
Neurotoxicology, NCTR/FDA, Jefferson, AR.<br />
#675 9:10 MAGNETIC RESONANCE IMAGING OF<br />
METALS IN THE BRAIN. D. C. Dorman. CIIT<br />
Centers for Health Research, Research Triangle Park,<br />
NC.<br />
#676 9:45 MOLECULAR IMAGING OF CENTRAL<br />
NERVOUS SYSTEM BIOLOGY IN SMALL<br />
ANIMALS. M. G. Pomper. Department <strong>of</strong> Radiology,<br />
Pharmacology, and Molecular Sciences and Oncology,<br />
Johns Hopkins University School <strong>of</strong> Medicine,<br />
Baltimore, MD. Sponsor: W. Slikker.<br />
#677 10:20 MRS TO ASSESS DEVELOPMENTAL<br />
NEUROTOXICITY. C. Cloak. Manoa School <strong>of</strong><br />
Medicine, University <strong>of</strong> Hawai’i, Honolulu, HI.<br />
Sponsor: W. Slikkers, Jr.<br />
PLATFORM SESSION: DEVELOPMENTAL TOXICOLOGY<br />
Chairperson(s): Anne Greenlee, OHSU, LaGrande, OR and Barbara Abbott,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#679 8:30 EARLY EXPOSURE TO TCDD IMPAIR RAT<br />
BONE TISSUE COMPOSITION AND FUNCTION.<br />
M. P. Lind 1 , H. M. Miettinen 2 , J. Orberg 3 , M.<br />
Backstrom 1 , I. Pettersson 3,1 , S. Larsson 4 and M.<br />
Viluksela 2 . 1 Institute <strong>of</strong> Environmental Medicine,<br />
Karolinska Institutet, Stockholm, Sweden, 2 Department<br />
<strong>of</strong> Environmental Health, National Public Health<br />
Institute, Kuopio, Finland, 3 Department <strong>of</strong><br />
Environmental <strong>Toxicology</strong>, Uppsala University,<br />
Uppsala, Sweden and 4 Department <strong>of</strong> Orthopaedics,<br />
Uppsala University Hospital, Uppsala, Sweden.<br />
Sponsor: G. Johansson.<br />
#680 8:50 EXPRESSION OF EGFR AND ITS LIGANDS IN<br />
RESPONSE TO TCDD OR RETINOIC ACID IN<br />
EGF AND TGFα KO FETAL MOUSE PALATE. B.<br />
D. Abbott 1 , H. Boyd 2 , C. Wood 1 and G. Held 1 . 1 Repro.<br />
<strong>Toxicology</strong>. Division, U.S. EPA/ORD/NHEERL,<br />
Research Triangle Park, NC and 2 MARC <strong>Program</strong>,<br />
NCCU, Durham, NC.<br />
#681 9:10 A ROBUST EXAMINATION OF EFFECTS OF<br />
TCDD ON THE DEVELOPING MALE<br />
REPRODUCTIVE SYSTEM. D. R. Bell 1 , G. Loizou 2 ,<br />
S. White 3 , A. Fernandes 3 , M. Rose 3 , B. G. Miller 4 , L.<br />
Tran 4 , S. Clode 5 , P. M. Foster 6 and A. MacNicoll 3 .<br />
1 2 Biology, Nottingham, Notts, United Kingdom, HSL,<br />
Sheffield, United Kingdom, 3 CSL, York, United<br />
Kingdom, 4 IOM, Edinburgh, United Kingdom,<br />
5 6 Covance, Harrogate, United Kingdom and NIEHS,<br />
Raleigh, NC.<br />
#682 9:30 COMPARISON OF MATRIGEL AND GELATIN<br />
SUBSTRATA FOR FEEDER-FREE CULTURE OF<br />
UNDIFFERENTIATED MOUSE EMBRYONIC<br />
STEM CELLS FOR TOXICITY TESTING. A. R.<br />
Greenlee 1,2 , T. A. Kronenwetter-Koepel 2 , S. J. Kaiser 2<br />
and K. Liu 3 . 1 School <strong>of</strong> Nursing and Center for<br />
Research on Occupational and Environmental<br />
<strong>Toxicology</strong>, OHSU, La Grande, OR, 2 Marshfield Clinic<br />
Research Foundation, Marshfield, WI and 3 Department<br />
<strong>of</strong> Biostatistics, Forest Research Institute, Jersey City,<br />
NJ.<br />
102<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#683 9:50 ALTERED TRANSCRIPTIONAL RESPONSES IN<br />
MOUSE EMBRYOS EXPOSED TO<br />
BISINDOLYLMALEIMIDE I (BIS I) IN WHOLE<br />
EMBRYO CULTURE. E. D. Karoly 1,2 , J. E. Schmid 2 ,<br />
M. R. Blanton 2 and E. S. Hunter III 2 . 1 Curriculum in<br />
<strong>Toxicology</strong>, UNC Chapel Hill, Chapel Hill, NC and<br />
2 Reproductive <strong>Toxicology</strong> Division, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#684 10:10 FOLATE PREVENTION OF OXIDATIVE STRESS<br />
IN FUMONISIN-INDUCED NEURAL TUBE<br />
DEFECTS. J. B. Gelineau-van Waes, J. Wilberding, F.<br />
Aleman, L. Bauer and J. Maddox. Department <strong>of</strong><br />
Genetics, Cell Biology & Anatomy, University <strong>of</strong><br />
Nebraska Medical Center, Omaha, NE. Sponsor: G.<br />
Bennett.<br />
#685 10:30 MATERNAL IMMUNE STIMULATION<br />
REDUCES DIABETES INDUCED<br />
CRANIOFACIAL MALFORMATIONS. S. D.<br />
Holladay 1,2 , T. C. Hrubec 2,1 , R. Prater 2,1 and K. Toops 1 .<br />
1 Veterinary Medicine, Virginia Tech, Blacksburg, VA<br />
and 2 Biomedical Sciences, College <strong>of</strong> Osteopathic<br />
Medicine, Blacksburg, VA.<br />
#686 10:50 ARSENIC TOXICITY: MOLECULAR AND<br />
DEVELOPMENTAL MECHANISMS IN<br />
MISCARRIAGE. J. C<strong>of</strong>fin 1 , W. He 2 , R. J. Greenwell 1 ,<br />
J. C. Pfau 1 , D. Brooks 1 , M. Bently 3 , T. J. Poole 3 and H.<br />
D. Beall 1 . 1 CEHS, University <strong>of</strong> Montana, Missoula,<br />
MT, 2 University <strong>of</strong> Pittsburg, Pittsburg, PA and 3 SUNY<br />
Upstate Medical University, Syracuse, NY.<br />
#687 11:10 SYNERGISTIC DEVELOPMENTAL TOXICITY<br />
OF POLYCYCLIC AROMATIC<br />
HYDROCARBONS: TOWARDS A<br />
MECHANISTIC UNDERSTANDING. R. Di Giulio 1 ,<br />
S. Billiard 1 , J. Meyer 3 , D. Wassenberg 1 and P. Hodson 2 .<br />
1 2 Duke University, Durham, NC, Queens University,<br />
Kingston, ON, Canada and 3 NIEHS, Research Triangle<br />
Park, NC.<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room RO8<br />
PLATFORM SESSION: METALS TOXICOLOGY<br />
Chairperson(s): Joyce S. Tsuji, Exponent Environmental Group Inc.,<br />
Bellevue, WA and Michael P. Waalkes, NIEHS, Research Triangle Park, NC.<br />
#688 8:30 ARSENIC TRIOXIDE INHIBITS NUCLEAR<br />
EXPRESSION OF RXR AND BINDING OF RXR-<br />
CONTAINING HETERODIMERS. K. K. Mann, A.<br />
M. Padovani and W. H. Miller. Lady Davis Institute for<br />
Medical Research, McGill University, Montreal, QC,<br />
Canada.<br />
#689 8:50 P53 MODULATES ARSENITE-INDUCED<br />
MITOTIC DISRUPTION AND ALTERED GENE<br />
EXPRESSION. S. C. McNeely 1 , B. Taylor 1 , X. Xu 1 , W.<br />
Zacharias 2,1 , M. J. McCabe 3 and J. States 1 .<br />
1 Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong> Louisville,<br />
Louisville, KY, 2 Medicine, University <strong>of</strong> Louisville,<br />
Louisville, KY and 3 Environmental Medicine,<br />
University <strong>of</strong> Rochester, Rochester, NY.<br />
#690 9:10 P53 SUPPRESSION OF ARSENITE INDUCED<br />
MITOTIC ARREST IS MEDIATED BY P21. B.<br />
Taylor 1 , S. C. McNeely 1 , H. L. Miller 1 , M. J. McCabe 2<br />
and J. States 1 . 1 Pharmacology & <strong>Toxicology</strong>, University<br />
<strong>of</strong> Louisville, Louisville, KY and 2 Environmental<br />
Medicine, University <strong>of</strong> Rochester, Rochester, NY.<br />
#691 9:30 ARSENIC EXPOSURE ACCELERATES<br />
ATHEROGENIC CHANGES IN APOE-/- MICE. J.<br />
States 1 , S. Srivastava 3 , U. Sen 2 , H. L. Miller 1 and S. E.<br />
D’Souza 2 . 1 Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong><br />
Louisville, Louisville, KY, 2 Physiology & Biophysics,<br />
University <strong>of</strong> Louisville, Louisville, KY and 3 Medicine,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#692 9:50 EXAMINING BIOMARKERS OF EXPOSURE<br />
AND PREPARATION TECHNIQUES FOR<br />
ARSENIC QUANTITATION IN BIOLOGICAL<br />
STUDIES. B. M. Adair 1 , E. E. Hudgens 2 , R. L.<br />
Calderon 2 and D. J. Thomas 1 . 1 Experimental<br />
<strong>Toxicology</strong> Division/NHEERL, U.S. EPA, Research<br />
Triangle Park, NC and 2 Human Sudies<br />
Division/NHEERL, U.S. EPA, Chapel Hill, NC.<br />
#693 10:10 BIOMONITORING OF A COMMUNITY FOR<br />
SOIL ARSENIC EXPOSURE. J. S. Tsuji 1 , M. D. Van<br />
Kerkhove 2 , C. G. Scrafford 3 and R. S. Kaetzel 1 .<br />
1 2 Exponent, Bellevue, WA, Exponent, New York and<br />
3 Exponent, Washington, DC.<br />
#694 10:30 CARCINOGENIC EFFECTS OF CADMIUM<br />
CHLORIDE, CISPLATIN AND NICKEL<br />
SUBSULFIDE IN METALLOTHIONEIN-I/II<br />
DOUBLE KNOCKOUT MICE. M. Waalkes 1 , J. Liu 1 ,<br />
K. Kasprzak 3 and B. Diwan 2 . 1 Laboratory <strong>of</strong><br />
Comparative Carcinogenesis, NCI at NIEHS, Research<br />
Triangle Park, NC, 2 NCI at Frederick, Frederick, MD<br />
and 3 BRP, SAIC-Frederick, NCI at Frederick, Frederick,<br />
MD.<br />
#695 10:50 LEAD IS A RISK FACTOR FOR<br />
OSTEOARTHRITIS: MOLECULAR<br />
MECHANISMS. J. E. Puzas, K. Hochberg, M. Zuscik,<br />
T. Sheu, E. Schwarz, R. O’Keefe and R. Rosier.<br />
Department <strong>of</strong> Orthopaedics, University <strong>of</strong> Rochester<br />
School <strong>of</strong> Medicine, Rochester, NY.<br />
#696 11:10 DISSOLUTION RATES OF NANOPARTICULATE<br />
METALLIC SPECIES IN ARTIFICIAL HUMAN<br />
SWEAT UNDER PHYSIOLOGICALLY<br />
RELEVANT CONDITIONS. N. J. Szabo, S. C.<br />
Wasdo, G. Brubaker, C. M. Jenkins and S. M. Roberts.<br />
University <strong>of</strong> Florida, Gainesville, FL.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 103
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
Tuesday Morning, March 8<br />
8:30 AM to 11:30 AM<br />
Room 220<br />
PLATFORM SESSION: EVALUATING DNA<br />
DAMAGE AND REPAIR<br />
Chairperson(s): Toby G. Rossman, New York University School <strong>of</strong> Medicine,<br />
Tuxedo, NY and John E. French, NIEHS, Research Triangle Park, NC.<br />
#697 8:30 GENETIC TOXICOLOGY TESTING IN HTS. R.<br />
M. Walmsley 1,2 , P. Cahill 2 , A. Knight 2 and N.<br />
Billinton 2 . 1 Biomolecular Sciences, UMIST,<br />
Manchester, England, United Kingdom and 2 Product<br />
Development, Gentronix Ltd., Manchester, United<br />
Kingdom. Sponsor: S. Dean.<br />
#698 8:50 AMES II AND DEREK VERSUS THE STANDARD<br />
AMES PROTOCOL: A COMPARATIVE STUDY.<br />
C. Andreas, K. Braun, I. Stammberger, H. Spirkl and A.<br />
Amberg. San<strong>of</strong>i-Aventis, Hattersheim, Germany.<br />
Sponsor: M. Bonnefoi.<br />
#699 9:10 STUDY IN VITRO OF THE TUMORIGENIC<br />
ACTION OF ACRYLAMIDE ON THYROID<br />
CELLS. J. DUMONT 1 , J. Van Sande 1 , C. Massart 1 , M.<br />
Friedman 2 and V. CHICO-GALDEZ 1 . 1 I.R.I.B.H.M.,<br />
ULB, Brussels, Belgium and 2 Free Consultant, Orlando,<br />
FL.<br />
#700 9:30 UNEXPECTED CLASTOGENICITY OF SOME<br />
PHARMACEUTICALS IS DUE TO DNA<br />
INTERCALATION. R. D. Snyder 1 , G. B. Zairov 1 and<br />
L. B. Hendry 2 . 1 Investigative and Molecular<br />
<strong>Toxicology</strong>, Schering-Plough, Lafayette, NJ, 2 Schering-<br />
Plough, Lafayette, NJ and 3 Accelerated<br />
Pharmaceuticals, Augusta, GA.<br />
#701 9:50 PHOSPHOTRIESTER ALKYLATION OF DNA BY<br />
MNU AND MMS. L. H. Pottenger, F. Zhang, M. J.<br />
Bartels, M. R. Schisler and B. B. Gollapudi. <strong>Toxicology</strong><br />
and Environmental Research & Consulting, The Dow<br />
Chemical Company, Midland, MI.<br />
#702 10:10 RECOGNITION AND REPAIR OF BUTADIENE<br />
EPOXIDE DNA ADDUCTS: INVOLVEMENT OF<br />
NUCLEOTIDE EXCISION REPAIR. J. Wickliffe 1 ,<br />
O. Masters 2 , S. Herring 1 , M. Ammenheuser 1 , L.<br />
Galbert 1 , J. Xie 1 , R. S. Lloyd 3 and J. Ward 1 . 1 University<br />
<strong>of</strong> Texas Medical Branch, Galveston, TX, 2 University <strong>of</strong><br />
Oklahoma, Norman, OK and 3 Oregon Health and<br />
Science University, Portland, OR.<br />
#703 10:30 BENZO[A]PYRENE-DNA ADDUCTS DERIVED<br />
FROM DIOL-EPOXIDE AND QUINONE<br />
PATHWAYS. Q. Ruan 1 , Q. Dai 2 , H. Kim 1 , R. G.<br />
Harvey 2 , T. M. Penning 1 and I. A. Blair 1 . 1 Department<br />
<strong>of</strong> Pharmacology, University <strong>of</strong> Pennsylvania,<br />
Philadelphia, PA and 2 Ben May Institute for Cancer<br />
Research, University <strong>of</strong> Chicago, Chicago, IL. Sponsor:<br />
S. Burchiel.<br />
#704 10:50 SIGNALING PATHWAYS FOR DNA DAMAGE<br />
AND REPAIR, APOPTOSIS AND LYMPHOID<br />
PROGENITOR CELL SURVIVAL ARE<br />
DYSREGULATED BY N-ACETYL-L-CYSTEINE.<br />
J. E. French 1 , K. R. Martin 2 , F. W. Kari 1 and J. C.<br />
Barrett 3 . 1 Laboratory <strong>of</strong> Molecular <strong>Toxicology</strong>, NIEHS,<br />
NIH, Research Triangle Park, NC, 2 Nutrition and<br />
Cancer Laboratory, Pennsylvania State University,<br />
University Park, PA and 3 Laboratory <strong>of</strong> Biosystems and<br />
Cancer, NCI, Bethesda, MD.<br />
#705 11:10 PREVENTION OF ARSENIC CO-<br />
CARCINOGENESIS BY SELENIUM<br />
COMPOUNDS. T. G. Rossman, A. N. Uddin and F. J.<br />
Burns. Environment Med., New York University School<br />
<strong>of</strong> Medicine, Tuxedo, NY.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 I<br />
Chairperson(s): Xinxin Ding, New York State Department <strong>of</strong> Health, Albany,<br />
NY.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#706 CELLULAR DISTRIBUTION OF SELECTIVE<br />
AGE DEPENDENT TESTICULAR<br />
CYTOCHROME P450-DEPENDENT<br />
ALKOXYRESORUFIN O-DEALKYLATION IN<br />
SPRAGUE-DAWLEY RATS. J. E. Seng 1 , J. Gandy 2 ,<br />
R. Ansari 2 and J. Leakey 3 . 1 Charles River Laboratories,<br />
Discovery and Developmental Services, Redfield, AR,<br />
2 Department <strong>of</strong> Pharmacology & <strong>Toxicology</strong>, University<br />
<strong>of</strong> Arkansas Medical Sciences, Little Rock, AR and<br />
3 National Center for Toxicological Research, Jefferson,<br />
AR.<br />
#707 ORAL ADMINISTRATION OF EGCG IS NON-<br />
TOXIC AND MODULATES CYP19 AND CYP2E1<br />
IN THE FEMALE BALB/C MOUSE. M. J. Scandlyn,<br />
M. G. Goodin and R. J. Rosengren. Pharmacology &<br />
<strong>Toxicology</strong>, University <strong>of</strong> Otago, Dunedin, New<br />
Zealand.<br />
#708 MAJOR DETERMINANTS IN SEX DIFFERENCE<br />
ON DAILY RHYTHM OF HEPATIC P450<br />
MONOOXYGENASE ACTIVITIES IN RATS. J.<br />
Hirao 1 , S. Arakawa 1 , M. Nishimura 2 , N. Niino 1 , K. Ito 1 ,<br />
N. Kiyosawa 1 , K. Muramatsu 1 and T. Furukawa 1 .<br />
1 Medicinal Safety Research Laboratories, SANKYO<br />
CO., LTD., Fukuroi, Shizuoka, Japan and 2 Biomedical<br />
Research Laboratories, SANKYO CO., LTD.,<br />
Shinagawa, Tokyo, Japan. Sponsor: N. Matsunuma.<br />
104<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#709 INTERINDIVIDUAL VARIATION OF<br />
EXPRESSION LEVEL OF CYP3A4 AND ITS<br />
RELATED PHARMACOGENETIC GENES IN<br />
JAPANESE LIVER TISSUE. A. Miyajima-Tabata 1 , S.<br />
Ozawa 1 , J. He 1 , H. Tanaka 2 , K. Nakai 2 , M. Sunouchi 1 ,<br />
Y. Kamikawa 3 , K. Kubota 4 , H. Ogata 2 and Y. Ohno 1 .<br />
1 Division <strong>of</strong> Pharmacology, National Institute <strong>of</strong> Health<br />
Sciences, Setagaya, Tokyo, Japan, 2 Department <strong>of</strong><br />
Biopharmaceutics, Meiji Pharmaceutical University,<br />
Kiyose, Tokyo, Japan, 3 Department <strong>of</strong> Pharmacology,<br />
Dokkyo University School <strong>of</strong> Medicine, Mibu, Tochigi,<br />
Japan and 4 Second Department <strong>of</strong> Surgery, Dokkyo<br />
University School <strong>of</strong> Medicine, Mibu, Tochigi, Japan.<br />
Sponsor: M. Ema.<br />
#710 USE OF NOVEL MULTIPLEXED QPCR ASSAYS<br />
TO ACCURATELY QUANTIFY HUMAN<br />
CYTOCHROME P450 EXPRESSION. R. D.<br />
Larsen 1 , C. Chang 1 , M. Tan 1 , C. Patten 2 and S. Parikh 2 .<br />
1 2 BD Biosciences Clontech, Palo Alto, CA and BD<br />
Biosciences Discovery Labware, Billerica, MA.<br />
Sponsor: D. Stresser.<br />
#711 USING P450-GLO LUMINESCENT ASSAYS TO<br />
SCREEN FOR XENOBIOTIC EFFECTS ON<br />
CYTOCHROMES P450. J. Cali 1 , D. Liu 1 , R. Bulliet 1<br />
and D. Ma 1 . 1 Promega Corp, Madison, WI and 2 R&D,<br />
Promega Biosciences, Sac Louis Obispo, CA.<br />
#712 DIOXIN AND DIET EFFECTS ON GROWTH AND<br />
P450 INDUCTION. M. La Merrill 1 and D. W.<br />
Threadgill 2,1 . 1 Curriculum in <strong>Toxicology</strong>, UNC-CH,<br />
Chapel Hill, NC and 2 Genetics, UNC-CH, Chapel Hill,<br />
NC.<br />
#713 DIOXIN INDUCTION OF CYP1A1 EXPRESSION<br />
IS SUPPRESSED IN HEPATITIS C VIRUS<br />
REPLICATING CELLS. G. R. Anderson, A. Hasan, I.<br />
Qadri and L. C. Quattrochi. Medicine, University <strong>of</strong><br />
Colorado Health Sciences Ctr, Denver, CO.<br />
#714 DIFFERENTIAL REGULATION OF LIVER<br />
MITOCHONDRIAL CYTOCHROME P4501A1<br />
(P450MT2) BY 3-METHYLCHOLANTHRENE IN<br />
MICE DEFICIENT IN THE CYTOCHROME<br />
P4501A2 GENE. B. Moorthy, S. Kondraganti and W.<br />
Jiang. Pediatrics, Baylor College <strong>of</strong> Medicine, Houston,<br />
TX.<br />
#715 ENDOGENOUS SUBSTRATES OF CYP1B1<br />
WHICH MAY BE ENDOGENOUS LIGANDS OF<br />
THE ARYL HYDROCARBON RECEPTOR. B.<br />
Stapleton 1 , A. Annalora 1 , C. Chiaro 5 , M. Doshi 3 , A.<br />
Bailey 1 , J. Omdahl 2 , B. Bejjani 4 , D. Edward 3 , G.<br />
Perdew 5 and C. Marcus 1 . 1 <strong>Toxicology</strong>, University New<br />
Mexico, Albuquerque, NM, 2 Biochemistry, University<br />
New Mexico, Albuquerque, NM, 3 Opthalmology &<br />
Visual Sciences., University IL, Chicago, IL, 4 Genetics<br />
& Pediatrics, WA. St. University, Spokane, WA and<br />
5 Cell & Molecular Biology, Penn. St. University,<br />
University Park, PA.<br />
#716 THE RESPONSE OF THE RAT HEPATIC P450<br />
SYSTEM TO FIVE ARCHETYPAL HUMAN<br />
MICROSOMAL ENZYME INHIBITORS. S. J.<br />
Schomaker, S. E. Boldt and D. E. Amacher. Safety<br />
Sciences Groton, Pfizer Inc., Groton, CT.<br />
#717 EFFECTS OF DIESEL EXHAUST PARTICLES ON<br />
CYTOCHROME P450 ACTIVITIES IN PRIMARY<br />
CULTURES OF ADULT RAT HEPATOCYTES: A<br />
USEFUL INDICATOR FOR THE STUDY OF<br />
HEALTH RISK. T. Jeon 1 , S. Hyun 1 , S. Lee 1 , C. Jin 1 ,<br />
D. Lee 1 , G. Kim 1 , I. Jun 1 , K. Chung 2 , C. Moon 3 and T.<br />
Jeong 1 . 1 College <strong>of</strong> Pharmacy, Yeungnam University,<br />
Kyungsan, South Korea, 2 College <strong>of</strong> Pharmacy,<br />
Sungkyunkwan University, Suwon, South Korea and<br />
3 College <strong>of</strong> Pharmacy, Seoul National University, Seoul,<br />
South Korea.<br />
#718 IN VITRO EVALUATION OF HISTAMINE AND<br />
ITS MAJOR METABOLITES AS INHIBITORS OR<br />
INDUCERS OF CYTOCHOME P450<br />
EXPRESSION IN HUMAN LIVER. S. A. Tonetta 1 , F.<br />
Nodikum-M<strong>of</strong>for 2 , B. L. Paris 2 and B. M. Richard 1 .<br />
1 Nonclinical, Maxim Pharmaceuticals, San Diego, CA<br />
and 2 Metabolism, Xenotech LLC, Lenexa, KS.<br />
#719 COMPARATIVE STUDIES OF CYTOCHROME<br />
P4503A4 INDUCTION RESPONSE IN PRIMARY<br />
CULTURES OF CRYOPRESERVED AND FRESH<br />
HUMAN HEPATOCYTES. J. Johnson 1 , C. M.<br />
Chandler 1 , S. Kim 2 , L. Tarabelsi 1 , D. M. Stresser 1 , M.<br />
Sinz 2 and J. G. Zhang 1 . 1 BD Discovery Labware,<br />
woburn, MA and 2 Bristol Myers Squibb Co.,<br />
Wallingford, CT.<br />
#720 REGULATIONS OF HUMAN CYP3A4<br />
PROXIMAL AND XREM PROMOTER<br />
ACTIVITIES IN HEPA I AND HEPG2 CELLS. Y. Y.<br />
Sheen, K. N. Min, J. Y. An, K. E. Joung, Y. W. Kim and<br />
D. Kim. Pharmacy, Ewha Womans University, Seoul,<br />
seoul, South Korea. Sponsor: J. Chung.<br />
#721 ROLE OF NF-κB IN REGULATION OF PXR<br />
TRANSCRIPTIONAL ACTIVITY: A<br />
MECHANISM FOR THE SUPPRESSION OF<br />
CYTOCHROME P450 3A4 BY INFLAMMATORY<br />
AGENTS. X. Gu 1 , T. Sheng 2 , S. Ke 1 , P. E. Thomas 3 ,<br />
M. A. Gallo 3 , W. Xie 4 and Y. Tian 1 . 1 Interdisciplinary<br />
Faculty <strong>of</strong> <strong>Toxicology</strong>, College Station, TX, 2 The<br />
University <strong>of</strong> Texas Medical Branch, Galveston, TX,<br />
3 EOHSI, Rutgers University, Piscataway, NJ and<br />
4 University <strong>of</strong> Pittsburgh, Pittsburgh, PA.<br />
#722 DOWN-REGULATION OF HEPATIC<br />
CYTOCHROME P450S IN ENDOTOXEMIC<br />
MICE IS INDEPENDENT OF PEROXISOME<br />
PROLIFERATOR ACTIVATED RECEPTOR<br />
ALPHA (PPARα). T. Richardson and E. T. Morgan.<br />
Pharmacology, Emory University, Atlanta, GA.<br />
#723 GENERATION AND CHARACTERIZATION OF A<br />
TRANSGENIC MOUSE MODEL WITH HEPATIC<br />
EXPRESSION OF HUMAN CYP2A6. J. Gu, Q.<br />
Zhang, T. Su, H. Cui, X. Zhuo, P. J. Swiatek, L. Zhang,<br />
W. Yang and X. Ding. Wadsworth Center, Albany, NY.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 105
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#724 AFFINITY LABELING OF SER-57 IN RAT<br />
CYTOCHROME P450C24A1 (CYP24A1) OF THE<br />
VITAMIN D PATHWAY: MUTATION AND<br />
CHARACTERIZATION. A. J. Annalora 1,2 , A.<br />
Pastusyzn 2 , R. Ray 3 , C. B. Marcus 1 and J. L. Omdahl 2 .<br />
1 College <strong>of</strong> Pharmacy, University <strong>of</strong> New Mexico,<br />
Albuquerque, NM, 2 Department <strong>of</strong> Biochemistry and<br />
Molecular Biology, University <strong>of</strong> New Mexico,<br />
Albuquerque, NM and 3 Vitamin D Laboratory, Boston<br />
University-SOM, Boston, MA.<br />
#725 THE USE OF THE MECHANISM BASED<br />
INHIBITOR 2-ETHYNYLNAPHTHALENE (2EN)<br />
TO PROBE THE ACTIVE SITE OF CYP2B4. D.<br />
Cheng, J. R. Reed, R. W. Kelley and W. L. Backes.<br />
Pharmacology, LSUHSC, New Orleans, LA.<br />
#726 INHIBITION OF THE HUMAN LIVER<br />
MICROSOMAL AND HUMAN CYTOCHROME<br />
P450 1A2 AND 3A4 METABOLISM OF<br />
ESTRADIOL BY DEPLOYMENT-RELATED<br />
CHEMICALS. K. A. Usmani, R. L. Rose and E.<br />
Hodgson. Environmental & Molecular <strong>Toxicology</strong>,<br />
North Carolina State University, Raleigh, NC.<br />
#727 CORRELATIONS BETWEEN ACTIVITIES OF<br />
CYPS 2E1/1A2 AND HISTOLOGIC FIBROSIS IN<br />
HCV PATIENTS. S. I. Shedl<strong>of</strong>sky 1,3 , R. T. Tosheva 1 ,<br />
C. Hallberg 2 and K. E. Anderson 2 . 1 Medicine,<br />
University <strong>of</strong> Kentucky, Lexington, KY, 2 University <strong>of</strong><br />
Texas Medical Branch, Galveston, TX and 3 General<br />
Clinical Research Center, Lexington, KY.<br />
#728 ROLE OF CYTOCHROME P450 2E1 (CYP2E1) IN<br />
TRICHLOROETHYLENE (TCE) METABOLISM<br />
AND DISPOSITION: COMPARATIVE STUDIES<br />
USING CYP2E1-/- AND WILD-TYPE MICE. D.<br />
Kim and B. I. Ghanayem. Laboratory <strong>of</strong> Pharmacology<br />
and Chemistry, NIEHS/NIH, Research Triangle Park,<br />
NC.<br />
#729 CYTOCHROME P450 2E1 (CYP2E1) INDUCTION<br />
BY PYRIDAZINE PRODUCES QUALITATIVE<br />
AND QUANTITATIVE CHANGES IN THE<br />
METABOLISM OF TRICHLOROETHYLENE TO<br />
POTENTIALLY CARCINOGENIC<br />
METABOLITES. S. Lee, S. Muralidhara, C. A. White<br />
and J. V. Bruckner*. Department <strong>of</strong> PBS, University <strong>of</strong><br />
Georgia, Athens, GA.<br />
#730 PROTECTIVE EFFECT OF DIALLYL SULFONE<br />
AGAINST LUNG MUTAGENESIS INDUCED BY<br />
VINYL CARBAMATE. L. G. Hernandez and P.<br />
Forkert. Department <strong>of</strong> Anatomy and Cell Biology,<br />
Queen’s University, Kingston, ON, Canada.<br />
#731 ROLE OF TOXICOKINETICS IN THE<br />
BIOACTIVATION-MEDIATED LIVER INJURY<br />
OF THIOACETAMIDE IN AD LIBITUM FED AND<br />
DIET RESTRICTED RATS. J. Chilakapati, M. C.<br />
Korrapati and H. M. Mehendale. <strong>Toxicology</strong>, University<br />
<strong>of</strong> Louisiana at Monroe, Monroe, LA.<br />
#732 CYP2E1 OXIDATION MEDIATES THE SPERM<br />
TOXICITY OF 1-BROMOPROPANE IN MICE. C.<br />
Garner 1 , J. Davis 1 , C. Sloan 1 , J. Burgess 1 , A. Jeffcoat 1 ,<br />
A. Hughes 1 , A. Parham 1 , J. Mathews 1 , L. Burka 2 and B.<br />
Ghanayem 2 . 1 DMPK, RTI International, Research<br />
Triangle Park, NC and 2 NIEHS, Research Triangle<br />
Park, NC.<br />
#733 HEPATIC METABOLISM OF AROMATIC AMINE<br />
HAIR DYE COMPONENTS AS COMPARED<br />
WITH THAT OF 2-AMINOFLUORENE. L.<br />
Stanley 1 , J. Skare 2 , E. Doyle 1 , R. Powrie 1 , D. D’<br />
Angelo 2 and C. Elcombe 1 . 1 CXR Biosciences Ltd.,<br />
Dundee, United Kingdom and 2 Central Product Safety,<br />
Sharon Woods Technical Center, Procter & Gamble<br />
Company, Cincinnati, OH.<br />
#734 DECHLORINATION OF PCB IUPAC #101 BY<br />
HUMAN CYP 2B6 TRANSFECTED INSECT CELL<br />
MICROSOMES. D. P. Waller and J. E. McGraw.<br />
Biopharmaceutical Sciences, University <strong>of</strong> Illinois at<br />
Chicago College <strong>of</strong> Pharmacy, Chicago, IL.<br />
#735 REGIO-SPECIFIC (ω TO ω-6) FATTY ACID<br />
(LAURIC, MYRISTIC AND PALMITIC)<br />
HYDROXYLATION IN HUMAN POOLED LIVER<br />
AND RECOMBINANT MICROSOMES. M. L.<br />
Haasch and J. C. Allgood. National Center for Natural<br />
Products Research, Environmental <strong>Toxicology</strong> Research<br />
<strong>Program</strong>, Pharmacology, The University <strong>of</strong> Mississippi,<br />
University, MS.<br />
#736 ROLE OF CYTOCHROME P450 3A IN<br />
HEPATOTOXICITY OF THE<br />
CHLOROACETANILIDE HERBICIDE<br />
ALACHLOR. S. R. Miranda and S. A. Meyer.<br />
<strong>Toxicology</strong>, University <strong>of</strong> Louisiana at Monroe,<br />
Monroe, LA.<br />
#737 INTERINDIVIDUAL VARIABILITY IN P450-<br />
MEDIATED METABOLISM OF 4-<br />
(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-<br />
BUTANONE(NNK) IN HUMAN WHOLE<br />
PERIPHERAL LUNG MICROSOMES. P. J. Brown 1 ,<br />
K. R. Reid 2 , D. Petsikas 2 and T. E. Massey 1 .<br />
1 Pharmacology and <strong>Toxicology</strong>, Queen, Kingston, ON,<br />
Canada and 2 Surgery, Queen’s University, Kingston,<br />
ON, Canada.<br />
#738 COMPARATIVE METABOLISM OF AFLATOXIN<br />
B1 (AFB1) BY ZEBRAFISH, RAINBOW TROUT<br />
AND HUMAN CYTOCHROMES P450. C. L.<br />
Miranda, W. Chung, J. Wang and D. R. Buhler.<br />
Environment & Molec. <strong>Toxicology</strong>, Oregon State<br />
University, Corvallis, OR.<br />
#739 EXPRESSION AND CHARECTERIZATION OF<br />
CHANNEL CATFISH CYP 2X1. S. MOSADEGHI,<br />
B. Furnes, C. Wong and D. Schlenk. Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California, Riverside, CA.<br />
#740 CHARACTERIZATION AND COMPARISON OF<br />
METHODS FOR VESICULAR<br />
RECONSTITUTION OF CYTOCHROME P450<br />
2B4 AND NADPH P450 REDUCTASE. J. R. Reed, R.<br />
W. Kelley and W. L. Backes. Pharmacology, Louisiana<br />
State University Health Science Center, New Orleans,<br />
LA.<br />
106<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: HEPATOCARCINOGENESIS<br />
Chairperson(s): Alan M. Jeffrey, New York Medical College, Valhalla, NY and<br />
Lisa M. Kamendulis, Indiana University School <strong>of</strong> Medicine, Indianapolis, IN.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#741 QUANTITATIVE DOSE-RESPONSE EFFECTS OF<br />
ACETYLAMINOFLUORENE<br />
HEPATOCARCINOGENESIS IN RATS. A. M.<br />
Jeffrey, M. J. Iatropoulos, J. Duan and G. M. Williams.<br />
New York Medical College, Valhalla, NY.<br />
#742 INFLUENCE OF STRAIN AND DIET ON<br />
HEPATOCARCINOGENICITY OF N-BUTYL-N-(4-<br />
HYDROXYBUTYL)NITROSAMINE (BBN) IN<br />
RATS. A. Hagiwara 1 , T. Murai 2 , E. Miyata 1 , Y. Toda 1 ,<br />
M. Sano 1 , S. Mori 2 and S. Fukushima 2 . 1 Daiyu-kai<br />
Institute <strong>of</strong> Medical Science, Ichinomiya, Japan and<br />
2 Department <strong>of</strong> Pathology, Osaka City University<br />
Medical School, Osaka, Japan.<br />
#743 THIAMETHOXAM INDUCED MOUSE LIVER<br />
TUMORS AND THEIR RELEVANCE TO<br />
HUMANS 1. MODE OF ACTION STUDIES IN<br />
THE MOUSE. S. Lloyd 2 , T. Green 2 , A. Toghill 2 , R.<br />
Lee 2 , F. Waechter 2 , J. Noakes 2 and T. P. Pastoor 1 .<br />
1 Syngenta Crop Protection, Greensboro, NC and<br />
2 Syngenta Central <strong>Toxicology</strong> Laboratory, Alderley<br />
Park, United Kingdom.<br />
#744 THIAMETHOXAM INDUCED MOUSE LIVER<br />
TUMORS AND THEIR RELEVANCE TO<br />
HUMANS 2. SPECIES DIFFERENCES IN<br />
RESPONSE. C. Waterfield 2 , T. Green 2 , R. Lee 2 , A.<br />
Toghill 2 , F. Waechter 2 , R. Peffer 1 , J. Noakes 2 , M.<br />
Robinson 2 and T. P. Pastoor 1 . 1 Syngenta Crop<br />
Protection, Greensboro, NC and 2 Syngenta CTL,<br />
Alderley Park, Cheshire, United Kingdom.<br />
#745 THIAMETHOXAM INDUCED MOUSE LIVER<br />
TUMORS AND THEIR RELEVANCE TO<br />
HUMANS 3. WEIGHT OF EVIDENCE<br />
EVALUATION. T. P. Pastoor 1 , P. Rose 2 , S. Lloyd 2 , R.<br />
Peffer 1 and T. Green 2 . 1 Syngenta Crop Protection,<br />
Greensboro, NC and 2 Syngenta CTL, Alderley Park,<br />
Cheshire, United Kingdom.<br />
#746 ESTIMATION OF A NO OBSERVED EFFECT<br />
LEVEL FOR 4, 4′-OXYDIANILINE, A<br />
GENOTOXIC LIVER CARCINOGEN, IN A 16-<br />
WEEK FEEDING STUDY USING MALE F344<br />
RATS. Y. Doi 1 , N. Imai 1 , A. Hagiwara 1 , H. Yoshino 1 , S.<br />
Tamano 1 , H. Wanibuchi 2 , K. Morimura 2 and S.<br />
Fukushima 2 . 1 Daiyu-Kai Institute <strong>of</strong> Medical Science,<br />
Inc., Ichinomiya, Japan and 2 Department <strong>of</strong> Pathology,<br />
Osaka City University Medical School, Osaka, Japan.<br />
#747 MUTAGENICITY OF PYRROLIZIDINE<br />
ALKALOIDS IN RAT LIVER. T. Chen, N. Mei and<br />
R. H. Heflich. Division <strong>of</strong> Genetic and Reproductive<br />
<strong>Toxicology</strong>, NCTR/FDA, Jefferson, AR.<br />
#748 EXPERIMENTAL STUDY ON CARCINOGENESIS<br />
INDUCED BY CYANOBACTERIAL<br />
MICROCYSTINS AND ORGANIC EXTRACTS OF<br />
TAP WATER. J. ZHAO 1,2 , S. Jiang 1 , W. Qu 1 and H.<br />
Zhu 1 . 1 EOH, Fudan University, Shanghai, China and<br />
2 EOH, University <strong>of</strong> Pitt, Pittsburgh, PA. Sponsor: J.<br />
Jiang.<br />
#749 INHIBITION OF GAP JUNCTIONAL<br />
INTERCELLULAR COMMUNICATION BY<br />
CHLOROHYDROXYFURANONES IN WB-F344<br />
CELLS. E. Rintala, P. Hakulinen, J. Maki-Paakkanen<br />
and H. Komulainen. Department <strong>of</strong> Environmental<br />
Health, National Public Health Institute, Kuopio,<br />
Finland. Sponsor: J. Tuomisto.<br />
#750 α2-MACROGLOBULIN: A NOVEL<br />
CYTOCHEMICAL MARKER<br />
CHARACTERIZING PRENEOPLASTIC AND<br />
NEOPLASTIC RAT LIVER LESIONS NEGATIVE<br />
FOR HITHERTO ESTABLISHED<br />
CYTOCHEMICAL MARKERS. T. Sukata 1,2 , S.<br />
Uwagawa 1,2 , K. Ozaki 1,2 , K. Sumida 1 , M. Kushida 1,2 ,<br />
K. Saito 1 , K. Morimura 2 , K. Oeda 1 , N. Mikami 1 and S.<br />
Fukushima 2 . 1 Environmental Health Science<br />
Laboratory, Sumitomo Chemical Co., Ltd.,, Osaka,<br />
Japan and 2 Pathology, Osaka City University Medical<br />
School, Osaka, Japan.<br />
#751 MECHANISMS OF 2-BUTOXYETHANOL<br />
CARCINOGENESIS. S. M. Corthals, L. M.<br />
Kamendulis and J. E. Klaunig. Division <strong>of</strong> <strong>Toxicology</strong>,<br />
Indiana University School <strong>of</strong> Medicine, Indianapolis,<br />
IN.<br />
#752 EVIDENCE FOR THE INVOLVEMENT OF THE<br />
KUPFFER CELL IN HEPATIC<br />
CARCINOGENESIS. L. M. Kamendulis, S. M.<br />
Corthals and J. E. Klaunig. Division <strong>of</strong> <strong>Toxicology</strong>,<br />
Indiana University School <strong>of</strong> Medicine, Indianapolis,<br />
IN.<br />
#753 MECHANISTIC ANALYSIS OF CARCINOGENIC<br />
AND NONCARCINOGENIC LIVER TOXICANTS<br />
USING TOXICOGENOMIC DATA DERIVED<br />
FROM RAT LIVER OR PRIMARY RAT<br />
HEPATOCYTES. M. S. Orr, K. K. Daniels and W. B.<br />
Mattes. Toxicogenomics, Gene Logic Inc.,<br />
Gaithersburg, MD.<br />
#754 DEVELOPMENT OF A GENE SIGNATURE THAT<br />
DISCRIMINATES BETWEEN GENOTOXIC AND<br />
NON-GENOTOXIC COMPOUNDS. G. Vansant, P.<br />
Pezzoli, C. Duffy and J. Monforte. Althea Technologies,<br />
San Diego, CA. Sponsor: F. Ferre.<br />
#755 A GENE EXPRESSION SIGNATURE FOR NON-<br />
GENOTOXIC CARCINOGENS. A. Y. Nie, M. K.<br />
McMillian, A. M. Leone, J. B. Parker, L. Piechta, S.<br />
Bryant, J. Herlich, M. Kemmerer, N. Raghavan, D.<br />
Amaratunga, L. Yieh, A. Bittner, J. Wan, M. D. Johnson<br />
and P. G. Lord. Mechanistic <strong>Toxicology</strong>, Johnson &<br />
Johnson PRD, LLC, Raritan, NJ.<br />
#756 EFFECTS OF 3-METHYLCHOLANTHRENE ON<br />
HEPATIC GENE EXPRESSION PATTERNS IN<br />
RATS USING CDNA MICROARRAY ANALYSES.<br />
S. Kondraganti, W. Jiang, K. Muthiah and B. Moorthy.<br />
Pediatrics, Baylor College <strong>of</strong> Medicine, Houston, TX.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 107
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#757 GENE EXPRESSION PROFILING IDENTIFIES<br />
GENE CHANGES INDICATIVE OF POTENTIAL<br />
EARLY NEOPLASTIC LIVER LESIONS CAUSED<br />
BY THE RODENT HEPATOCARCINOGEN<br />
METHYLEUGENOL. J. T. Auman, J. Foley and R. S.<br />
Paules. National Center for Toxicogenomics, NIEHS,<br />
Research Triangle Park, NC.<br />
#758 GENE REGULATION PATTERNS IN RAINBOW<br />
TROUT AFLATOXIN B 1 -INDUCED<br />
HEPATOCELLULAR CARCINOMA COMPARED<br />
TO NORMAL ADJACENT LIVER. S. C. Tilton 1,2 , J.<br />
D. Hendricks 1 , G. S. Bailey 1,2 and D. E. Williams 1,2 .<br />
1 Environmental & Molecular <strong>Toxicology</strong> Department<br />
and Marine & Freshwater Biomedical Sciences Center,<br />
Oregon State University, Corvallis, OR and 2 Linus<br />
Pauling Institute, Oregon State University, Corvallis,<br />
OR.<br />
#759 TOXICOGENOMIC ANALYSIS OF NUCLEAR<br />
RECEPTOR-MEDIATED AND -INDEPENDENT<br />
RESPONSES TO PEROXISOME<br />
PROLIFERATORS. C. G. Woods 1 , B. U. Bradford 1 ,<br />
M. L. Cunningham 2 , M. Kadiiska 3 , R. P. Mason 3 , A. M.<br />
Burns 4 , J. M. Peters 4 and I. Rusyn 1 . 1 Environmental<br />
Science and Engineering, UNC, Chapel Hill, NC, 2 NCT<br />
and NTP, NIEHS, Research Triangle Park, NC,<br />
3 Laboratory <strong>of</strong> Pharmacology and Chemistry, NIEHS,<br />
Research Triangle Park, NC and 4 Veterinary Science,<br />
PSU, University Park, PA. Sponsor: I. Rusyn.<br />
#760 COMPARATIVE EEFFECTS OF<br />
TRICHLORACETIC ACID ON RODENT AND<br />
HUMAN HEPATOCYTES: ROLE OF<br />
PEROXISOME PROLIFERATOR ACTIVATED<br />
RECEPTOR α (PPARα). D. J. Smith, X. Pu, L. M.<br />
Kamendulis and J. E. Klaunig. Division <strong>of</strong> <strong>Toxicology</strong>,<br />
Indiana University School <strong>of</strong> Medicine, Indianapolis,<br />
IN.<br />
#761 THE EFFECTS OF AMMONIUM<br />
PERFLUOROOCTANOATE (APFO) ON THE<br />
TRANSCRIPTIONAL PROFILE OF PANCREAS<br />
AND LIVER OF MALE RATS. S. Plummer, O.<br />
Vassieva and C. Elcombe. CXR Biosciences Ltd.,<br />
Dundee, United Kingdom.<br />
#762 EFFECT OF 6MONTS ADMINISTRATION OF<br />
HEPATIC TUMOR PROMOTERS ON IGF<br />
SIGNALING PATHWAY EXPRESSION IN THE<br />
RAT LIVER. A. Naito, S. Dial and Y. Dragan. Division<br />
<strong>of</strong> System <strong>Toxicology</strong>, NCTR, Jefferson, AR.<br />
#763 DIFFERENTIAL CHANGES OF GENE<br />
EXPRESSION PROFILES IN MALE LONG-<br />
EVANS CINNAMON AND F344 RATS BY THE<br />
ADMINISTRATION OF N-<br />
NITROSOMORPHOLINE. Y. Kawano 1 , K.<br />
Nakayama 1 , D. Nakae 2 , A. Maekawa 2 , M. Tsuchitani 1<br />
and M. Sekijima 1 . 1 Mitsubishi Chemical Safety Institute<br />
Ltd.,, Ibaraki, Japan and 2 Sasaki Institute, Sasaki<br />
Foundation, Tokyo, Japan.<br />
#764 DOWN-REGULATION OF E-CADHERIN BY THE<br />
INTEGRIN-LINKED KINASE PATHWAY (ILK) IN<br />
HEPATOCYTES; A POSSIBLE MECHANISM<br />
FOR HEXACHLOROBENZENE-INDUCED<br />
TUMOR PROMOTION. I. Plante, D. G. Cyr and M.<br />
Charbonneau. INRS-Institut Armand-Frappier,<br />
Universite du Quebec, Montreal, QC, Canada.<br />
#765 TOXICOGENOMIC APPROACH FOR<br />
PREDICTION OF HEPATOCARCINOGENS<br />
USING RAT HEPATOMA CELLS AND<br />
COMPARISON OF GENE EXPRESSION<br />
PATTERNS WITH CHEMICAL-TREATED RAT<br />
AND HUMAN HEPATOMA CELLS. K.<br />
TSUJIMURA 1,2 , M. Asamoto 1 , S. Suzuki 1 , K. Ogawa 1<br />
and T. Shirai 1 . 1 Department <strong>of</strong> Experimental Pathology<br />
and Tumor Biology, Nagoya City University Graduate<br />
School <strong>of</strong> Medical Sciences, Nagoya, Aichi, Japan and<br />
2 Chemicals Assessment Center, Hita laboratory,<br />
Chemicals Evaluation and Research Institute, Hita, Oita,<br />
Japan.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CHEMICAL & BIOLOGICAL WEAPONS<br />
Chairperson(s): Alan Brimfield, USAMRICD, Aberdeen Proving Groud, MD<br />
and Gary Rosenthal, RxKinetix, Louisville, CO.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#766 EVALUATION OF A VACCINE DELIVERY<br />
SYSTEM FOR RECOMBINANT ANTHRAX<br />
PROTECTIVE ANTIGEN IN RABBITS. J. M.<br />
Blonder 1 , C. Coeshott 1 , E. Verderber 1 , A. Samaniego 1 ,<br />
S. Smithson 2 , M. Westerink 2 and G. Rosenthal 1 .<br />
1 2 RxKinetix, Louisville, CO and Department Medicine,<br />
Medical College <strong>of</strong> Ohio, Toledo, OH.<br />
#767 HISTOLOGICAL RESPONSE OF RAT ORGANS<br />
TO REPEATED BLAST OVERPRESSURE<br />
EXPOSURE. EFFECTS OF NUMBER OF<br />
EXPOSURES AND TIME AFTER EXPOSURE. N.<br />
Elsayed 1,2 , N. Gorbunov 3 , A. Januszkiewicz 3 and J.<br />
Atkins 3 . 1 Hurley Consulting Associates, Chatham, NJ,<br />
2 SUNY Downstate Medical Center, Brooklyn, NY and<br />
3 Walter Reed Army Institute <strong>of</strong> Research, Silver Spring,<br />
MD.<br />
#768 DEVELOPMENT OF A MICROBIAL RISK<br />
ASSESSMENT METHODS COMPENDIUM AND<br />
ASSESSMENT OF SECONDARY DATA U. M.<br />
Coleman 1 , P. McClure 1 , P. McGinnis 2 , R. Starmer 1 , P.<br />
Rodgers 3 , I. Baumel 4,6 , J. Choich 4,7 and E. Brady-<br />
Roberts 4,5 . 1 Environ Sciences Ctr, Syracuse Research<br />
Corp, Syracuse, NY, 2 Syr Res Corp, Philadelphia, PA,<br />
3 Battelle Mem Inst, Columbus, OH,<br />
4 NHomeland Sec<br />
Res, U.S. EPA, Washington, DC, 5 NHomeland Sec Res,<br />
U.S. EPA, Cincinnati, OH, 6 U.S. EPA, Washington, DC<br />
and 7 Amer Assn Adv Sciences, Washington, DC.<br />
108<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#769 MICROARRAY ANALYSIS OF RAW264.7 CELLS<br />
EXPOSED TO BACILLUS ANTHRACIS-<br />
EVIDENCE OF VOLLUM 1B-INDUCED<br />
MACROPHAGE APOPTOSIS. B. W. Gutting and R.<br />
S. Mackie. NSWC Dahlgren, Dahlgren, VA.<br />
#770 DECONTAMINATION OF BACILLUS<br />
ANTHRACIS SPORES ON INDOOR BUILDING<br />
SURFACES USING FORMALDEHYDE GAS. W. R.<br />
Richter, Y. W. Choi, C. L. Sabourin, M. L. Taylor and J.<br />
V. Rogers. Battelle Memorial Institute, Columbus, OH.<br />
#771 DECONTAMINATION OF BACILLUS<br />
ANTHRACIS SPORES ON INDOOR BUILDING<br />
SURFACES USING HYDROGEN PEROXIDE<br />
GAS. Y. W. Choi, W. R. Richter, C. L. Sabourin, M. L.<br />
Taylor and J. V. Rogers. Battelle Memorial Institute,<br />
Columbus, OH.<br />
#772 A METHOD FOR THE SIMULTANEOUS<br />
MEASUREMENT OF SPECIFIC IGGS TO FIVE<br />
CDC SELECT BIOTERRORISM AGENTS IN<br />
SERUM. R. E. Biagini 1 , D. L. Sammons 1 , J. P. Smith 1 ,<br />
B. A. MacKenzie 1 , C. A. Striley 1 , S. A. Robertson 1 , J.<br />
E. Snawder 1 and C. P. Quinn 2 . 1 CDC/NIOSH,<br />
Cincinnati, OH and 2 CDC/NCID, Atlanta, GA.<br />
#773 GENERATION, METHODOLOGY AND<br />
ANALYSIS OF VX VAPOR. J. S. Anthony 1 , E. M.<br />
Jakubowski 1 , R. J. Mioduszewski 1 , S. A. Thomson 1 , K.<br />
L. Matson 2 , R. A. Evans 2 , C. L. Crouse 2 and J. M.<br />
McGuire 2 . 1 Edgewood Chemical Biological Center,<br />
Department <strong>of</strong> the Army, Aberdeen Proving Ground,<br />
MD and 2 Geo-Centers, Inc., Abingdon, MD.<br />
#774 CORRELATING GENE EXPRESSION PROFILES<br />
WITH THERAPEUTIC EFFICACY OF<br />
POTENTIAL VESICANT MEDICAL<br />
COUNTERMEASURES. J. F. Dillman 1 , L. M.<br />
Dorsch 1 , A. I. Hege 1 , A. J. Sylvester 1 , C. S. Phillips 1 , R.<br />
C. Kiser 2 , Y. W. Choi 2 and C. L. Sabourin 2 . 1 Applied<br />
Pharmacology, USAMRICD, Aberdeen Proving<br />
Ground, MD and 2 Medical Research and Evaluation<br />
Facility, Battelle Memorial Institute, Columbus, OH.<br />
#775 FLUORIDE ION REGENERATION OF<br />
CYCLOSARIN (GF) FROM MINIPIG TISSUE<br />
AND FLUIDS FOLLOWING WHOLE BODY GF<br />
MIOSIS LEVEL VAPOR EXPOSURE. E. M.<br />
Jakubowski 1 , J. M. McGuire 2 , R. A. Evans 2 , S. W.<br />
Hulet 1 , D. C. Burnett 1 , R. A. Way 1 , B. P. Gaviola 1 , J. A.<br />
Scotto 1 , W. T. Muse 1 , D. B. Miller 1 , R. J.<br />
Mioduszewski 1 and S. A. Thomson 1 . 1 <strong>Toxicology</strong> Team,<br />
Edgewood Chemical Biological Center, APG-<br />
Edgewood, MD and 2 Geo-Centers, Inc., Edgewood,<br />
MD.<br />
#776 CHOLINESTERASE AND SARIN (GB)<br />
REGENERATION PROFILE FOLLOWING LOW<br />
LEVEL GB IN GUINEA PIGS: USEFULNESS<br />
FOR PBPK MODELING. L. A. Lumley 1 , C.<br />
Whalley 2 , J. McGuire 3 , M. O’Malley 1 , A.<br />
D’Ambrozio 1 , C. Robison 1 , E. Mason 1 , C.<br />
Krauthauser 3 , E. Jakubowski 2 , S. McAvoy 1 , T.<br />
Rowland 1 , C. Clark 1 , R. Evans 3 , D. Miller 3 , T. Belski 3 ,<br />
J. Renner 3 , J. Scotto 2 , J. Jarvis 2 , J. Anthony 2 , C.<br />
Crouse 3 , J. McDonough 1 , R. Mioduszewski 2 , S.<br />
Thomson 2 and T. Shih 1 . 1 USAMRICD, Aberdeen<br />
Proving Ground, MD, 2 ECBC, Aberdeen Proving<br />
Ground, MD and 3 Geo-Centers, Aberdeen Proving<br />
Ground, MD.<br />
#777 PRETREATMENT OF HUMAN EPIDERMAL<br />
KERATINOCYTES WITH D, L SULFORAPHENE<br />
PROTECTS AGAINST SULFUR MUSTARD<br />
CYTOTOXICITY. C. L. Gross, E. W. Nealley, M. T.<br />
Nipwoda and W. J. Smith. USAMRICD, APG-EA, MD.<br />
Sponsor: A. Sciuto.<br />
#778 THE EFFECT OF SULFUR MUSTARD<br />
EXPOSURE ON THE PERCENT, SIZE AND<br />
DENSITY OF HUMAN T CELLS (CD3+). H. L.<br />
Meier and M. S. Oravitz. Biochemical Pharmacology<br />
Research Institute <strong>of</strong> Chemical Defense, Aberdeen<br />
Proving Ground, MD. Sponsor: S. Baskin.<br />
#779 EFFECT OF TOPICAL IODINE TREATMENT ON<br />
EARLY SULFUR-MUSTARD-INDUCED<br />
CUTANEOUS CHANGES AND EPIDERMAL-<br />
CELL PROLIFERATION. S. Trivedi 1 , U. Wormser 2 ,<br />
N. Flagler 1 , B. Brodsky 2 , S. Peddada 2 and A. Nyska 1 .<br />
1 Laboratory <strong>of</strong> Experimental Pathology, NIEHS,<br />
Research Triangle Park, NC and 2 School <strong>of</strong> Pharmacy,<br />
Faculty <strong>of</strong> Medicine, Institute <strong>of</strong> Life Sciences, The<br />
Hebrew University <strong>of</strong> Jerusalem, Jerusalem, Israel.<br />
#780 THE MATRIX METALLOPROTEINASE<br />
INHIBITOR GM 1489 REDUCES MMP-9<br />
ACTIVITY AFTER SULFUR MUSTARD<br />
EXPOSURE IN VIVO. D. R. Gerecke 1 , P. Bhatt 1 , Y.<br />
Chang 1 , C. L. Sabourin 2 , T. L. Rudge Jr. 2 , R. C. Kiser 2 ,<br />
S. L. Casbohm 2 , M. K. Gordon 1 , D. J. Riley 3 , M. P.<br />
Shakarjian 3 and R. P. Casillas 2 . 1 Pharmacology &<br />
<strong>Toxicology</strong>, Rutgers University, Piscataway, NJ,<br />
2 Battelle Memorial Inst., Med. Res. & Eval. Fac.,<br />
Columbus, OH and 3 Medicine, UMDNJ-Robert Wood<br />
Johnson Med. School, Piscataway, NJ.<br />
#781 OBSERVATIONS ON THE INTERACTION OF<br />
SULFUR MUSTARD WITH CYTOCHROME P450.<br />
A. A. Brimfield 1 and E. Hodgson 2 . 1 Biochemical<br />
Pharmacology, USAMRICD, Aberdeen Proving<br />
Ground, MD and 2 Environmental and Molecular<br />
<strong>Toxicology</strong>, North Carolina State University, Raleigh,<br />
NC.<br />
#782 PUTATIVE ROLE OF PLATELET ACTIVATING<br />
FACTOR (PAF) ANALOGS IN CELL CYCLE<br />
ABERRATIONS IN HUMAN ENDOTHELIAL<br />
CELLS IN VITRO. O. E. Clark, E. W. Nealley, K. W.<br />
Leiter, K. L. Finke, A. L. Miller and W. J. Smith.<br />
Pharmacology, USAMRICD, Aberdeen Proving<br />
Ground, MD.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 109
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#783 ORAL DOSING WITH N-ACETYL-L-CYSTEINE<br />
SIGNIFICANTLY INCREASES GLUTATHIONE<br />
LEVELS AND GLUTATHIONE-S-TRANSFERASE<br />
ACTIVITY IN RAT SKIN. E. Wilfong, A. J. Bobb, E.<br />
W. Johnson, S. L. Lohrke, R. H. Casavant and D. P.<br />
Arfsten. Naval Health Research Center Detachment<br />
Environmental Health Effects Laboratory, Wright-<br />
Patterson AFB, OH.<br />
#784 TOPICAL IODINE SUPPRESSES SULFUR-<br />
MUSTARD-INDUCED TUMOR NECROSIS<br />
FACTOR-ALPHA INDUCTION IN MOUSE-EAR<br />
MODEL. U. Wormser 1 , B. Brodsky 1 , E. Proscura 1 , J. F.<br />
Foley 2 , T. Jones 2 and A. Nyska 2 . 1 Pharmacology, The<br />
Hebrew University, Jerusalem, Israel and 2 Laboratory <strong>of</strong><br />
Experimental Pathology, NIEHS, Research Triangle<br />
Park, NC.<br />
#785 DEVELOPMENT OF INTERSPECIES AND<br />
MULTI-EXPOSURE ROUTE DOSE METRICS<br />
FOR SARIN VIA PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC/PHARMACODYNAMIC<br />
MODELLING. J. Gearhart 1 , K. Yu 2 , P. Robinson 1 , E.<br />
Jakubowski 3 , R. Mioduszewski 3 , C. Whalley 3 , S.<br />
Thompson 3 , T. Shih 4 , L. Lumley 4 and J. McDonough 4 .<br />
1 ManTech Environmental Technology, Inc., Wright-<br />
Patterson AFB, OH, 2 AFRL/HEPB, Wright-Patterson<br />
AFB, OH, 3 US Army Edgewood Chem Bio Center,<br />
Aberdeen Proving Ground, MD and 4 US Army MRICD,<br />
Aberdeen Proving Ground, MD.<br />
#786 A PBPK REGIONAL MODEL FOR NERVE<br />
AGENTS IN THE BRAIN. P. J. Robinson 1 , J. M.<br />
Gearhart 1 , K. O. Yu 1 , E. M. Jakubowski 2 , R. J.<br />
Mioduszewski 2 and S. A. Thomson 2 . 1 Wright-Patterson<br />
AFB, Dayton, OH and 2 Edgewood Chemical Biological<br />
Center, Aberdeen, MD.<br />
#787 SARIN (GB) REGENERATION AND<br />
CHOLINESTERASE PROFILES FOLLOWING<br />
INHALATION OF GB IN GUINEA PIGS:<br />
APPLICATION TO PBPK MODELING. C. E.<br />
Whalley 1 , L. A. Lumley 2 , E. M. Jakubowski 1 , J.<br />
McGuire 3 , C. Krauthauser 3 , D. Miller 3 , R. Evans 3 , T.<br />
Belski 3 , J. Renner 3 , J. Anthony 1 , C. Crouse 3 , J. Scotto 1 ,<br />
J. Jarvis 1 , A. Totura 3 , M. O’Malley 2 , A. D’Ambrozio 2 ,<br />
C. Robison 2 , E. Mason 2 , S. McAvoy 2 , T. Rowland 2 , C.<br />
Clark 2 , J. H. McDonough 2 , R. J. Mioduszewski 1 , T. M.<br />
Shih 2 and S. A. Thomson 1 . 1 ECBC, Aberdeen Proving<br />
Ground, MD, 2 USAMRICD, Aberdeen Proving Ground,<br />
MD and 3 Geo-Centers, Aberdeen Proving Ground, MD.<br />
#788 ESTIMATING LETHAL AND SEVERE TOXIC<br />
EFFECTS IN MINIPIGS FOLLOWING 10, 60 AND<br />
180-MINUTES OF WHOLE-BODY GB VAPOR<br />
EXPOSURE. S. W. Hulet 1 , D. R. Sommerville 1 , P. A.<br />
Dabisch 2 , B. J. Benton 1 , D. B. Miller 2 , J. S. Forster 1 , J.<br />
A. Scotto 1 , R. B. Crosier 1 , C. L. Krauthauser 2 , J. R.<br />
Jarvis 2 , J. H. Manthei 1 , W. T. Muse 1 , D. C. Burnett 1 , R.<br />
A. Moretz 1 , B. P. Gaviola 1 , R. J. Mioduszewski 1 and S.<br />
A. Thomson 1 . 1 <strong>Toxicology</strong>, US Army ECBC, Aberdeen<br />
Proving Grounds, MD and 2 GEO-Centers, Inc.,<br />
Abingdon, MD.<br />
#789 PRETREATMENT WITH CARBOXYESTERASE<br />
INHIBITOR CBDP SENSITIZES MICE TO<br />
SARIN: POTENTIAL MODEL FOR LOW-DOSE<br />
EXPOSURE ASSESSMENT. R. D. Grubbs, W. A.<br />
Price, J. B. Lucot and M. Morris. Pharmacology &<br />
<strong>Toxicology</strong>, Wright State University School <strong>of</strong><br />
Medicine, Dayton, OH.<br />
#790 GENISTEIN PROTECTS MICE FROM<br />
RADIATION-INDUCED WEIGHT LOSS. M. R.<br />
Landauer, J. Kramer, C. Pham and V. Srinivasan.<br />
AFRRI, Bethesda, MD.<br />
#791 LOW DOSE SARIN PRODUCES LONG LASTING<br />
CHANGES IN CARDIOVASCULAR FUNCTION.<br />
V. Farah, S. J. Paton and M. Morris. Pharmacology and<br />
<strong>Toxicology</strong>, Wright State University, Dayton, OH.<br />
Sponsor: J. McDougal.<br />
#792 EVIDENCE OF CYSTEINE LOADING IN SKIN<br />
AND OTHER TISSUES IN SPRAGUE-DAWLEY<br />
RATS DOSED AT 4-HOUR INTERVALS WITH N-<br />
ACETYL-L-CYSTEINE (1, 200 MG/KG). E. W.<br />
Johnson, E. R. Wilfong, A. J. Bobb and D. P. Arfsten.<br />
NHRC EHE Lab., Wright-Patterson AFB, OH.<br />
#793 LOW-LEVEL INHALATION EXPOSURE TO GB,<br />
GF AND VX INDUCES EXPRESSION OF<br />
NEURONAL APOPTOSIS AND REGENERATION<br />
GENES IN RAT. J. W. Sekowski 1 , J. Bucher 1 , M.<br />
Orehek 1 , M. Horsmon 1 , J. J. Valdes 1 , C. Whalley 1 , B.<br />
Benton 1 , W. Muse 1 , D. Miller 1 , J. Scotto 1 , J. Forster 1 , J.<br />
Manthei 1 , R. Way 1 , D. Burnett 1 , B. Gaviola 1 , R.<br />
Mioduszewski 1 , S. Thomson 1 , M. Nau 2 and M. Vahey 2 .<br />
1 Edgewood Chemical Biological Center, US Army<br />
RDECOM, APG-EA, MD and 2 Walter Reed Army<br />
Institute <strong>of</strong> Research, US Army MRMC, Rockville,<br />
MD.<br />
#794 MECHANISM OF THE MIOTIC TOLERANCE<br />
OBSERVED FOLLOWING MULTIPLE<br />
EXPOSURES TO SARIN VAPOR. P. A. Dabisch 2,1 ,<br />
D. B. Miller 3 , D. C. Burnett 1 , E. M. Jakubowski 1 , S. A.<br />
Reutter 1 , R. J. Mioduszewski 1 and S. Thomson 1 .<br />
1 Operational <strong>Toxicology</strong>, US Army Edgewood<br />
Chemical Biological Center, Aberdeen Proving Ground,<br />
MD, 2 National Research Council Postdoctoral<br />
Associate, National Academy <strong>of</strong> Sciences, Washington,<br />
DC and 3 Geo-Centers, Inc., Aberdeen Proving Ground,<br />
MD.<br />
#795 THE URINE CONCENTRATIONS OF 2-AMINO-2-<br />
THIAZOLINE-4- CARBOXYLIC ACID AS A<br />
BIOMARKER FOR CYANIDE IN SMOKING AND<br />
NON-SMOKING MALE AND FEMALE<br />
VOLUNTEERS. B. A. Logue 1 , S. I. Baskin 2 , G. A.<br />
Rockwood 2 , N. P. Kirschten 2 , S. Royster 2 , M.<br />
Keebaugh 2 and G. E. Plat<strong>of</strong>f 2 . 1 Drug Assessment,<br />
USAMRICD, Aberdeen Proving Ground, MD and<br />
2 South Dakota State University, Brookings, SD.<br />
#796 INTERACTION OF 2-AMINO-2-THIOZOLINE-4-<br />
CARBOXYLIC ACID WITH CYTOCHROME C<br />
OXIDASE IMMOBILIZED IN AN ELECTRODE-<br />
SUPPORTED LIPID BILAYER MEMBRANE. J. B.<br />
Kelly 2 , F. M. Hawkridge 2 , S. I. Baskin 1 , G. A.<br />
Rockwood 1 and G. E. Plat<strong>of</strong>f. 1 USAMRICD, Aberdeen<br />
Proving Ground, MD and 2 Chemistry, Virginia<br />
Commonwealth University, Richmond, VA.<br />
110<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SAFETY EVALUATION-BIOTECHNOLOGY<br />
PRODUCTS AND VACCINES<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#797 VALIDATION OF REAL TIME QUANTITATIVE<br />
PCR AND SAMPLE PREPARATION<br />
PROCEDURE IN BIODISTRIBUTION STUDY OF<br />
ADENOVIRUS VECTORS. B. Tian, S. S. Rentz, G. S.<br />
Gregory, R. Tina and J. G. Page. Southern Research<br />
Institute, Birmingham, AL.<br />
#798 SINGLE-DOSE TOXICITY STUDY OF AN<br />
ONCOLYTIC ADENOVIRUS ADMINISTERED BY<br />
INTRAVENOUS INFUSION TO CYNOMOLGUS<br />
MONKEYS. B. McIntyre 1 , S. Thibault 1 , N. Kishnani 2 ,<br />
D. Compton 1 , R. Veneziale 1 , J. Nelson 3 , R. Ralston 4,2<br />
and R. Morrissey 1 . 1 Schering-Plough Research Institute,<br />
Lafayette, NJ, 2 Schering-Plough Research Institute,<br />
Kenilworth, NJ, 3 Charles River Laboratories, Sierra<br />
Division, Sparks, NV and 4 Canji, San Diego, CA.<br />
#799 FIFTEEN-MONTH REPEATED DOSE<br />
SUBCUTANEOUS ADMINISTRATION STUDY OF<br />
RHFGF-2 IN ATHYMIC NUDE MICE. S. Tsunoda 1 ,<br />
T. Nakamura 1 , T. Sibanushi 1 , K. Kuzutani 1 and M.<br />
Takahashi 2 . 1 Safety Research Department, Kaken<br />
Pharmaceutical co., Ltd., Sizuoka, Japan and 2 Pathology<br />
Peer Review Center, Tokyo, Japan.<br />
#800 PRECLINICAL SAFETY OF RECOMBINANT<br />
HUMAN THROMBIN. J. K. Heffernan, R. Ponce, L.<br />
A. Zuckerman, J. Visich and M. Rogge. Preclinical<br />
Development, ZymoGenetics, Seattle, WA.<br />
#801 SAFETY ASSESSMENT OF MONOCLONAL<br />
ANTIBODY MAB216 + VINCRISTINE IN<br />
RABBITS. K. Steinmetz 1 , D. Fairchild 1 , N. Teng 2 , M.<br />
Bieber 2 , K. Schweikart 3 , J. Tomaszewski 3 and J.<br />
Mirsalis 1 . 1 SRI International, Menlo Park, CA,<br />
2 3 Stanford University, Stanford, CA and National<br />
Cancer Institute, Bethesda, MD.<br />
#802 RISING DOSE TOLERABILITY STUDIES OF A<br />
CHIMERIC ANTI-PHOSPHATIDYLSERINE<br />
MONOCLONAL ANTIBODY (TARVACIN) IN<br />
RATS AND CYNOMOLGUS MONKEYS. S.<br />
Carpenter 1 , C. Stewart 2 , L. Willis 2 and P. E. Thorpe 3 .<br />
1 2 Peregrine Pharmaceuticals, Inc., Tustin, CA, MPI<br />
Research, Inc., Mattawan, MI and 3 The University <strong>of</strong><br />
Texas Southwestern, Dallas, TX.<br />
#803 SAFETY EVALUATION OF A CHIMERIC ANTI-<br />
PHOSPHATIDYLSERINE MONOCLONAL<br />
ANTIBODY (TARVACIN) IN MICE USING A<br />
FULL-THICKNESS EXCISIONAL DERMAL<br />
WOUND MODEL. S. Carpenter 1 , T. Nguyen 2 and P.<br />
E. Thorpe 3 . 1 Peregrine Pharmaceuticals, Inc., Tustin,<br />
CA, 2 Explora Biolabs, LLC, La Jolla, CA and 3 The<br />
University <strong>of</strong> Texas Southwestern, Dallas, TX. Sponsor:<br />
L. Kamendulis.<br />
#804 REPRODUCTIVE AND DEVELOPMENTAL<br />
EFFECTS OF AVASTIN, A MONOCLONAL<br />
ANTIBODY AGAINST VASCULAR<br />
ENDOTHELIAL GROWTH FACTOR. C. L. Zuch 1 ,<br />
A. Bricarello 2 , J. C. Beyer 1 , P. J. Thomford 3 , B. J.<br />
Christian 3 and A. M. Hoberman 4 . 1 Safety Assessment,<br />
Genentech, Inc., South San Francisco, CA, 2 Study<br />
Management, Genentech, Inc., South San Francisco,<br />
CA, 3 Covance Laboratories, Inc., Madison, WI and<br />
4 Charles River Laboratories, Inc., Argus Research<br />
Division, Horsham, PA.<br />
#805 ACUTE TOXICITY STUDIES WITH A<br />
TRANSFORMING GROWTH FACTOR-BETA<br />
ANTAGONIST IN SPRAGUE-DAWLEY RATS<br />
AND CYNOMOLGUS MONKEYS. E. R. LaCasse,<br />
R. Pawliuk, J. DelCarpini, C. Rogers and L. Andrews.<br />
Pharmacology/<strong>Toxicology</strong>, Genzyme, Framingham,<br />
MA.<br />
#806 SAFETY EVALUATION OF A HUMAN FUSION<br />
PROTEIN PRO97796 (BR3-FC). T. R. Gelzleichter 1 ,<br />
T. Kamenosono 2 , D. M. Danilenko 1 , S. Ren 1 , A. Song 1 ,<br />
S. R. Brignoli 1 , T. M. Watson 1 and Y. Vugmeyster 1 .<br />
1 2 Genentech, South San Francisco, CA and SNBL,<br />
USA, Seattle, WA.<br />
#807 CJC-1295, A LONG-ACTING GROWTH<br />
HORMONE RELEASE FACTOR ANALOGUE, IS<br />
WELL TOLERATED IN DOGS UP TO 14 DAYS. V.<br />
Iordanova 1 , S. Wen 1 , B. Lawrence 1 , C. N. Papagiannis 2 ,<br />
S. Morseth 3 and J. Castaigne 1 . 1 ConjuChem, Inc.,<br />
Montreal, QC, Canada, 2 MPI Research, Inc., Mattawan,<br />
MI and 3 Morseth Consulting LLC, Jefferson, MD.<br />
#808 RODENT SUBCHRONIC TOXICITY STUDIES<br />
WITH THE PEPTIDE ANTIBIOTIC XMP.629. R.<br />
Hawks 1 , S. W. Frantz 2 , J. T. Secrest 2 and K. E. Meyer 1 .<br />
1 2 XOMA LLC, Berkeley, CA and MPI Research,<br />
Mattawan, MI.<br />
#809 SAFETY AND EFFICACY OF GLYCOSYLATED<br />
UNDENATURED TYPE II COLLAGEN (UC-II) IN<br />
OBESE-ARTHRITIC DOGS. R. C. Gupta 1 , L.<br />
DeParle 1 , T. Canerdy 1 , J. Goad 1 , M. Bagchi 2 and D.<br />
Bagchi 2 . 1 <strong>Toxicology</strong>, Murray State university,<br />
Hopkinsville, KY and 2 InterHealth Nutraceuticals Inc.,<br />
Benicia, CA.<br />
#810 PRECLINICAL SAFETY ASSESSMENT OF<br />
RECOMBINANT PLAGUE VACCINE (RF1V)<br />
FOLLOWING REPEAT-DOSE<br />
ADMINISTRATION. R. V. House 1 , J. Shearer 1 , S.<br />
Manetz 2 and S. Morris 1 . 1 DynPort Vaccine Company<br />
LLC, Frederick, MD and 2 Gene Logic Laboratories,<br />
Gaithersburg, MD.<br />
#811 PRECLINICAL SAFETY ASSESSMENT OF<br />
RECOMBINANT BOTULINUM VACCINE A/B<br />
(RBV A/B) FOLLOWING REPEAT-DOSE<br />
ADMINISTRATION. J. Shearer 1 , I. Henderson 1 , S.<br />
Manetz 2 and R. V. House 1 . 1 DynPort Vaccine Company<br />
LLC, Frederick, MD and 2 Gene Logic Laboratories.<br />
Inc., Gaithersburg, MD.<br />
TUESDAY<br />
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44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
TUESDAY<br />
#812 SPONTANEOUS HEMORRHAGE OF THE<br />
PANCREATIC ISLET IN SPRAGUE-DAWLEY<br />
RATS. M. Imaoka, T. Suzuki, K. Nozaki, H. Satoh, T.<br />
Sugawara and K. Furuhama. Drug Safety Research<br />
Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo,<br />
Japan.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SIGNAL TRANSDUCTION: OXIDANT STRESS<br />
Chairperson(s): Dean P. Jones, Emory University SOM, Atlanta, GA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#813 NRF2 ACTIVATION INVOLVES AN OXIDATIVE-<br />
STRESS INDEPENDENT PATHWAY IN<br />
TETRAFLUOROETHYLCYSTEINE-INDUCED<br />
CYTOTOXICITY. H. Ho 1 , C. White 2 , C. Fernandez 2 ,<br />
N. Fausto 3 , T. Kavanagh 2 , S. Nelson 1 and S. Bruschi 1 .<br />
1 Medicinal Chemistry, University <strong>of</strong> Washington,<br />
Seattle, WA, 2 Environmental and Occupational Health,<br />
University <strong>of</strong> Washington, Seattle, WA and 3 Pathology,<br />
University <strong>of</strong> Washington, Seattle, WA.<br />
#814 NRF2-DEPENDENT ARE ACTIVATION IS A<br />
GAIN OF FUNCTION ALTERATION SPECIFIC<br />
TO DIFFERENTIATED AND FUNCTIONALLY<br />
ACTIVATED ASTROCYTES. J. A. Johnson, J. Li, D.<br />
A. Johnson and M. J. Calkins. School <strong>of</strong> Pharmacy,<br />
University <strong>of</strong> Wisconsin, Madison, WI.<br />
#815 INDUCTION OF NAD(P)H:QUINONE<br />
OXIDOREDUCTASE 1 IN MOUSE LIVER<br />
DURING EXTRAHEPATIC CHOLESTASIS IS<br />
DEPENDENT UPON NRF2 ACTIVATION. A. L.<br />
Slitt 1 , L. M. Aleksunes 2 , J. M. Maher 1 , M. Z. Dieter 1 , N.<br />
J. Cherrington 3 , J. E. Manautou 2 , J. Y. Chan 4 and C. D.<br />
Klaassen 1 . 1 Pharmacology, <strong>Toxicology</strong>, & Therapeutics,<br />
University <strong>of</strong> Kansas Medical Center, Kansas City, KS,<br />
2 Pharmaceutical Sciences, University <strong>of</strong> Connecticut,<br />
Storrs, CT, 3 Pharmacology and <strong>Toxicology</strong>, University<br />
<strong>of</strong> Arizona, Tucson, AZ and 4 Pathology, University <strong>of</strong><br />
California Irvine, Irvine, CA.<br />
#816 ALTERATIONS IN GENE EXPRESSION BY 2378-<br />
TETRACHLORO-P-DIBENZODIOXIN (TCDD) IN<br />
LIVERS OF NRF2 KNOCKOUT MICE. M.<br />
Matsumoto 1 , H. Sato 2 , K. Itoh 3 , M. Yamamoto 3 and Y.<br />
Aoki 1 . 1 National Institute for Environmental Studies,<br />
Tsukuba, Japan, 2 Institute <strong>of</strong> Medicinal Molecular<br />
Design Inc., Tokyo, Japan and 3 University <strong>of</strong> Tsukuba<br />
TARA Center, Tsukuba, Japan.<br />
#817 PHOSPHORYLATION OF NRF2 BY CASEIN<br />
KINASE 2 (CK2) REGULATES ACTIVATION AND<br />
DEGRADATION. J. Pi 1,2 , Y. Bai 2 , J. Reece 3 , J.<br />
William 4 , D. Liu 5 , M. Freeman 6 , W. Fahl 7 , D. Shugar 8<br />
and M. Waalkes 1 . 1 Lab. <strong>of</strong> Comparative Carcinogenesis,<br />
NCI at NIEHS, Research Triangle Park, NC, 2 Division<br />
<strong>of</strong> Biology Sciences, CIIT Centers for Health Research,<br />
Research Triangle Park, NC, 3 LST, NIEHS, Research<br />
Triangle Park, NC, 4 LSB, NIEHS, Research Triangle<br />
Park, NC, 5 LRDT, NIEHS, Research Triangle Park, NC,<br />
6 Vanderbilt University School <strong>of</strong> Medicine, Nashvile,<br />
TN, 7 University <strong>of</strong> Wisconsin, Madison, WI and 8 Polish<br />
Academy <strong>of</strong> Sciences, Warsaw, Poland.<br />
#818 NRF3 NEGATIVELY REGULATES ARE-<br />
MEDIATED EXPRESSION AND ANTIOXIDANT<br />
INDUCTION OF DETOXIFYING ENZYME<br />
GENES. S. KANNAN and A. K. JAISWAL.<br />
Pharmacology, Baylor College <strong>of</strong> Medicine, Houston,<br />
TX. Sponsor: B. Moorthy.<br />
#819 ANTIOXIDANT INDUCED NUCLEAR IMPORT<br />
AND EXPORT OF OXIDATIVE STRESS-<br />
RESONSE FACTOR NRF2. A. K. Jain and A. K.<br />
Jaiswal. Pharmacology, Baylor College <strong>of</strong> Medicine,<br />
Houston, TX. Sponsor: B. Moorthy.<br />
#820 COMPARTMENTAL OXIDATION OF<br />
THIOL/DISULFIDE REDOX COUPLES DURING<br />
EGF SIGNALING. P. J. Halvey 1 , J. M. Hansen 1 , W. H.<br />
Watson 2 , Y. Go 1 and D. P. Jones 1 . 1 Medicine, Emory<br />
University, Atlanta, GA and 2 Environmental Health<br />
Sciences, Johns Hopkins University, Baltimore, MD.<br />
#821 UPREGULATION OF MRP3 AND MRP4 BY<br />
SULFHYDRYL-MODIFYING COMPOUNDS IS<br />
MEDIATED BY THE TRANSCRIPTION FACTOR<br />
NRF2. J. M. Maher 1 , M. Z. Dieter 1 , A. L. Slitt 1 , J. Y.<br />
Chan 2 and C. D. Klaassen 1 . 1 University <strong>of</strong> Kansas<br />
Medical Center, Kansas City, KS and 2 University <strong>of</strong><br />
California Irvine, Irvine, CA.<br />
#822 EPIGENETIC EFFECTS OF OXIDATIVE<br />
STRESS. B. Upham 1,2 and J. E. Trosko 1,2 .<br />
1 Pediatrics/Human Development, Michigan State<br />
University, East Lansing, MI and 2 National Food Safety<br />
& <strong>Toxicology</strong> Ctr., Michigan State University, East<br />
Lansing, MI.<br />
#823 HISTONE H3.3 MODIFICATIONS DURING<br />
REACTIVE OXYGEN SPECIES INDUCED DNA<br />
DAMAGE. R. Xie, T. T. Monks and S. S. Lau.<br />
Pharmacology and Toxicolocy, University <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
112<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CARDIOVASCULAR DISEASE II<br />
Chairperson(s): Paul Boor, University <strong>of</strong> Texas Medical Branch, Galveston,<br />
TX and Bernard Hennig, University <strong>of</strong> Kentucky, Lexington, KY.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#824 EVALUATION OF PLASMA VON WILLEBRAND<br />
FACTOR (VWF) AND VWF PROPEPTIDE IN<br />
DRUG-INDUCED VASCULAR INJURY. D. Brott 1,2 ,<br />
A. Katein 1 , K. Ershaw 1 , G. Evans 3 , H. Jones 3 , S.<br />
Gould 3 , G. Betton 3 , J. Valentin 3 , R. J. Richardson 2 and<br />
C. Louden 1,2 . 1 Global Safety Assessment, AstraZeneca<br />
Pharmaceuticals, Wilmington, DE, 2 <strong>Toxicology</strong><br />
<strong>Program</strong>, Environmental Health Science Department,<br />
The University <strong>of</strong> Michigan, Ann Arbor, MI and<br />
3 Global Safety Assessment, AstraZeneca<br />
Pharmaceuticals, Alderley, United Kingdom.<br />
#825 MORPHOLOGIC IMAGING OF<br />
EXTRACELLULAR MATRIX IN CHEMICAL-<br />
INDUCED DEVELOPMENTAL DISSECTING<br />
AORTIC ANEURYSM USING MULTIPHOTON<br />
FLORESCENCE AND SECOND HARMONIC<br />
GENERATION MICROSCOPY BIN GONG, JU<br />
SUN, GRACIE VARGAS, PAUL BOOR. B. gong 1 , J.<br />
Sun 2 , G. Vargas 2 and P. boor 1 . 1 pathology, UTMB at<br />
Galveston, Galveston, TX and 2 biomedical engineering<br />
center, UTMB at Galveston, Galveston, TX.<br />
#826 EFFECTS OF GONADAL STEROIDS ON<br />
CALCIUM CURRENTS AND ACTION<br />
POTENTIALS IN GUINEA PIG CARDIAC<br />
MUSCLES. S. Nagayama, K. Yunomae, S. Ichisaki, J.<br />
Matsuo, M. Haruyama, K. Fukuzaki, R. Nagata and G.<br />
Kito. Shin Nippon Biomedical Laboratories, Ltd<br />
(SNBL), Kagoshima, Japan.<br />
#827 NUCLEOSIDE ANALOG REVERSE<br />
TRANSCRIPTASE INHIBITOR (NRTI)-INDUCED<br />
ρ – RAT CARDIAC MYOCYTES IN CELL<br />
CULTURE. A. Rolo, J. A. Bjork and K. B. Wallace.<br />
Biochemistry & Molecular Biology, University <strong>of</strong><br />
Minnesota Medical School, Duluth, MN.<br />
#828 EPHENDRINE AND CAFFEINE CAUSE<br />
SIGNIFICANT MORTALITY IN 14 WEEK OLD<br />
BUT NOT IN 7 WEEK OLD FISCHER RATS. P.<br />
Hanlon 1 , R. Howden 2 , J. Petranka 1 , S. Kleeberger 2 , J.<br />
Dunnick 3 , A. Nyska 4 and E. Murphy 1 . 1 Laboratory <strong>of</strong><br />
Signal Transduction, NIEHS, Research Triangle Park,<br />
NC, 2 Laboratory <strong>of</strong> Respiratory Biology, NIEHS,<br />
Research Triangle Park, NC, 3 <strong>Toxicology</strong> Branch,<br />
NIEHS, Research Triangle Park, NC, 4 Laboratory <strong>of</strong><br />
Environmental Pathology, NIEHS, Research Triangle<br />
Park, NC and 5 NIEHS, Research Triangle Park, NC.<br />
#829 ACUTE HEMORRHAGIC MYOCARDIAL<br />
NECROSIS AND SUDDEN DEATH OF RATS<br />
EXPOSED TO A COMBINATION OF<br />
EPHEDRINE AND CAFFEINE. A. Nyska 1 , E.<br />
Murphy 2 , J. F. Foley 1 , B. J. Collins 4 , J. Petranka 2 , R.<br />
Howden 3 , P. Hanlon 2 and J. K. Dunnick 4 . 1 Laboratory<br />
<strong>of</strong> Experimental Pathology, NIEHS, Research Triangle<br />
Park, NC, 2 Laboratory <strong>of</strong> Signal Transduction, NIEHS,<br />
Research Triangle Park, NC, 3 Laboratory <strong>of</strong> Respiratory<br />
Biology, NIEHS, Research Triangle Park, NC and<br />
4 Environmental <strong>Toxicology</strong> <strong>Program</strong>, NIEHS, Research<br />
Triangle Park, NC.<br />
#830 EFFECTS OF HYPOKALIEMIA ON THE QT<br />
INTERVAL IN DOGS. A. Yvon, J. Provost, Y.<br />
Rabemampianina and G. Hanton. Pfizer PGRD,<br />
Amboise, France. Sponsor: H. Sterz.<br />
#831 DOES AUTONOMIC NERVOUS TONE<br />
DIRECTLY AFFECT THE QT INTERVAL? T.<br />
Harada, J. Abe, M. Shiotani, Y. Hamada and I. Horii.<br />
PGRD Nagoya Lab., Pfizer Inc., Taketoyo, Aichi, Japan.<br />
Sponsor: M. Kurata.<br />
#832 SENSITIVITY OF CANINE AND RABBIT<br />
CARDIAC REPOLARIZATION ASSAYS FOR<br />
DETECTION OF POTENTIAL QT LIABILITY. J.<br />
Kramer. ChanTest, Inc., Cleveland, OH. Sponsor: T.<br />
Narahashi.<br />
#833 ACCURATE EVALUATION OF QT INTERVAL IN<br />
CONSCIOUS CYNOMOLGUS MONKEYS BY<br />
USE OF TELEMETRY ECG. K. Kuwano, T.<br />
Jikuzono, S. Otsuka, M. Hijioka, T. Miyake, T. Uchino,<br />
M. Shoki, T. Koga, K. Fukuzaki, R. Nagata and G.<br />
Kito. Shin Nippon Biomedical Laboratories, Ltd.,<br />
(SNBL), Kagoshima, Japan.<br />
#834 NEW SAFETY ASSESSMENT ON LEFT<br />
VENTRICULAR VOLUME AND ITS FUNCTION<br />
IN MONKEYS USING THREE-DIMENSIONAL<br />
ECHOCARDIOGRAPHY. T. Yamada 1 , H. Tsusaki 1 ,<br />
H. Yonamine 1 , A. Tamai 1 , M. Shimomoto 2 , G. Kito 1<br />
and R. Nagata 1 . 1 Shin Nippon Biomedical Laboratories,<br />
Ltd.,, Kagoshima, Japan and 2 Philips Medical Systems,<br />
Fukuoka, Japan.<br />
#835 HERG LIABILITY: THINKING OUTSIDE THE<br />
BLOCK. B. Wible. ChanTest, Inc., Cleveland, OH.<br />
Sponsor: T. Narahashi.<br />
#836 VARIABILITY IN THE MEASUREMENT OF<br />
HERG POTASSIUM CHANNEL INHIBITION:<br />
EFFECTS OF TEMPERATURE AND STIMULUS<br />
PATTERN. G. Kirsch. ChanTest, Inc., Cleveland, OH.<br />
Sponsor: T. Narahashi.<br />
#837 VALIDATION OF QT EVALUATION IN<br />
CONSCIOUS GUINEA PIGS WITH A<br />
TELEMETRY SYSTEM. M. Shiotani 1 , T. Harada 1 , J.<br />
Abe 1 , Y. Hamada 1 , K. Hashimoto 2 and I. Horii 1 . 1 PGRD<br />
Nagoya Lab., Pfizer Inc., Taketoyo, Aichi, Japan and<br />
2 Interdisciplinary Graduate School <strong>of</strong> Medicine and<br />
Engineering, University <strong>of</strong> Yamanashi, Nakakoma,<br />
Yamanashi, Japan. Sponsor: M. Kurata.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 113
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#838 ASTEMIZOLE : SPECIES DIFFERENCES IN QT<br />
PROLONGATION AND ARRHYTHMOGENESIS.<br />
J. Le Bigot, P. Lainee, A. Betat, G. Froget, L. Camus<br />
and R. Forster. CIT, Evreux, France.<br />
#839 VALIDATION OF THE ISOLATED RABBIT<br />
HEART FOR CARDIOVASCULAR SAFETY<br />
ASSESSMENT. E. Tanhehco, P. Senese and M.<br />
Gralinski. CorDynamics, Inc., Chicago, IL.<br />
#840 NON-SURGICAL TELEMETRY TECHNIQUES<br />
FOR ELECTROCARDIOGRAM (ECG)<br />
DETERMINATION IN DOGS AND MONKEYS<br />
DURING TOXICOLOGY STUDIES. P. Shaver-<br />
Walker, M. Vezina, N. Leblond and C. Copeman. IPN,<br />
CTBR Bio-Research Inc., Senneville, QC, Canada.<br />
#841 GENERATION OF BACKGROUND<br />
ELECTROCARDIOGRAM (ECG) TELEMETRY<br />
DATA IN DOGS USING A POSITIVE CONTROL<br />
SUBSTANCE (DL-SOTALOL) FOR QT<br />
PROLONGATION. M. Vezina, N. Leblond, K.<br />
Tenneson and C. Copeman. IPN, CTBR Bio-Research<br />
Inc., Senneville, QC, Canada.<br />
#842 THE ROLE OF CALPAIN-CALPASTATIN<br />
SYSTEM IN 2-BUTOXYETHANOL-INDUCED<br />
HEMOLYSIS. P. S. Palkar, V. S. Bhave, B. K. Philip,<br />
P. B. Limaye and H. M. Mehendale. Department <strong>of</strong><br />
<strong>Toxicology</strong>, University <strong>of</strong> Louisiana at Monroe,<br />
Monroe, LA.<br />
#843 ADHESION-MOLECULE CHANGES IN 2-<br />
BUTOXYETHANOL (BE) FISCHER F344 RAT<br />
MODEL FOR THROMBOTIC SEQUELAE OF<br />
HEMOLYTIC ANEMIAS. T. L. Ortel 2 , A. Potti 2 , D.<br />
Lewis 2 , J. Wu 2 and A. Nyska 1 . 1 Laboratory <strong>of</strong><br />
Experimental Pathology, NIEHS, Research Triangle<br />
Park, NC and 2 Division <strong>of</strong> Hematology, Duke<br />
University Medical Center, Durham, NC.<br />
#844 2-BUTOXYETHANOL FEMALE RAT MODEL OF<br />
HEMOLYSIS AND DISSEMINATED<br />
THROMBOSIS: X-RAY CHARACTERIZATION<br />
OF OSTEONECROSIS AND GROWTH PLATE<br />
SUPPRESSION. D. N. Lewis 1 , K. Johnson 1 , D.<br />
Malarkey 1 , S. Ward 1 , M. Streicker 3 , S. Shabat 4 , S.<br />
Peddada 2 , M. Nyska 4 and A. Nyska 1 . 1 Laboratory <strong>of</strong><br />
Experimental Pathology, NIEHS, Research Triangle<br />
Park, NC, 2 Biostatistics Branch, NIEHS, Research<br />
Triangle Park, NC, 3 Integrated Laboratory Systems<br />
(ILS), Research Triangle Park, NC and 4 Department <strong>of</strong><br />
Orthopaedic Surgery, Sapir Medical Center, Kfar-Saba,<br />
44281, Israel.<br />
#845 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN<br />
ALTERS FETAL MURINE CARDIAC GROWTH<br />
AND GENE EXPRESSION, AND LEADS TO<br />
CARDIAC HYPERTROPHY AND ALTERED<br />
CARDIAC FUNCTION AFTER BIRTH. E. A.<br />
Thackaberry, B. A. Nunez, I. D. Ivnitski-Steele and M.<br />
K. Walker. College <strong>of</strong> Pharmacy, U <strong>of</strong> New Mexico,<br />
Albuquerque, NM.<br />
#846 SUB-CHRONIC, LOW LEVEL 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN (TCDD)<br />
EXPOSURE INCREASES BLOOD PRESSURE IN<br />
ADULT MICE AS MEASURED BY TELEMETRY.<br />
P. G. Kopf, A. K. Lund and M. K. Walker. College <strong>of</strong><br />
Pharmacy, University <strong>of</strong> New Mexico, Albuquerque,<br />
NM.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: PBPK MODELS<br />
Chairperson(s): Jeffery Fisher, Univeristy <strong>of</strong> Georgia, Athens, GA and Elaina<br />
Kenyon, U.S. EPA, Research Triangle Park, NC.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#847 A HARMONIZED PBPK MODEL FOR<br />
TRICHLOROETHYLENE RISK ASSESSMENT. T.<br />
R. Covington 1 , H. J. Clewell 1 , J. W. Fisher 2 , D. A.<br />
Keys 2 , C. Hack 3 and J. Q. Zhao 3 . 1 ENVIRON Health<br />
Sciences Institute, Ruston, LA, 2 University <strong>of</strong> Georgia,<br />
Athens, GA and 3 <strong>Toxicology</strong> Excellence for Risk<br />
Assessment, Cincinnati, OH.<br />
#848 PHYSIOLOGICAL MODELING OF THE<br />
DERMAL ABSORPTION OF<br />
OCTAMETHYLCYCLOTETRASILOXANE (D4)<br />
AND DECAMETHYLCYCLOPENTASILOXANE<br />
(D5). M. B. Reddy 1 , K. P. Plotzke 2 , J. R. Looney 3 , M. J.<br />
Utell 3 , M. L. Jovanovic 2 , J. M. McMahon 2 , D. A.<br />
McNett 2 and M. E. Andersen 4 . 1 Colorado State<br />
University, Fort Collins, CO, 2 Dow Corning<br />
Corporation, Midland, MI, 3 University <strong>of</strong> Rochester,<br />
Rochester, NY and 4 CIIT, Research Triangle Park, NC.<br />
#849 ALTERATION OF HEXACHLOROBENZENE<br />
DISPOSITION BY PCB126 COEXPOSURE AND<br />
APPLICATION OF PBPK MODELING IN A<br />
MEDIUM-TERM LIVER FOCI BIOASSAY. Y. LU,<br />
M. Lohitnavy, O. Lohitnavy, E. Perrigo and R. Yang.<br />
Environmental and Radiological Health Sciences,<br />
Colorado State University, Fort Collins, CO.<br />
#850 PREDICTIVE PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODELING OF<br />
PYRETHROID PESTICIDES. S. J. Godin 1 , R.<br />
Tornero-Velez 2 , E. J. Scollon 3 , M. F. Hughes 3 and M. J.<br />
Devito 3 . 1 Curriculum in <strong>Toxicology</strong>, University <strong>of</strong> North<br />
Carolina, Chapel Hill, NC, 2 NERL, U.S. EPA, ORD,<br />
Research Triangle Park, NC and 3 NHEERL, U.S. EPA,<br />
ORD, Research Triangle Park, NC.<br />
#851 ROUTE-TO-ROUTE EXTRAPOLATION OF<br />
METABOLIC INTERACTIONS IN MIXTURES<br />
OF ALKYLBENZENES USING A PBPK MODEL.<br />
R. Tardif, A. Nong and K. Krishnan. Occupational and<br />
Environmental Health, Universite de Montreal,<br />
Montreal, QC, Canada.<br />
#852 A PBPK MODEL FOR A MIXTURE OF DIOXIN-<br />
LIKE CHEMICALS. M. Easterling 1 , N. J. Walker 2 , F.<br />
M. Parham 2 and C. J. Portier 2 . 1 Constella Group,<br />
Durham, NC and 2 NIEHS, Durham, NC.<br />
114<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#853 A HUMAN PBTK MODEL DESCRIBING<br />
ACETONE KINETICS IN BREATH AND BLOOD<br />
AT DIFFERENT WORKLOADS. A. Mork and G.<br />
Johanson. Work Environment <strong>Toxicology</strong>, Karolinska<br />
Institute, Stockholm, Sweden.<br />
#854 EVALUATION OF ORAL AND INTRAVENOUS<br />
ROUTE PHARMACOKINETICS, PLASMA<br />
PROTEIN BINDING AND UTERINE TISSUE<br />
DOSE METRICS OF BISPHENOL A: A<br />
PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC APPROACH. J. G.<br />
Teeguarden 1 , J. M. Waechter 3 , H. J. Clewell 2 , T. R.<br />
Covington 2 and H. A. Barton 4 . 1 Biological Monitoring<br />
and Modeling, Pacific Northwest National Laboratory,<br />
Richland, WA, 2 ENVIRON International, Ruston, LA,<br />
3 The Dow Chemical Company, Midland, MI and<br />
4 NHEERL, U.S. EPA, Research Triangle Park, NC.<br />
#855 LACK OF BIOACCUMULATION WITH<br />
REPEATED, PERIODIC EXPOSURES OF<br />
CYCLIC SILOXANES. M. E. Andersen 1 , M. B.<br />
Reddy 2 and K. P. Plotzke 3 . 1 CIIT, Research Triangle<br />
Park, NC, 2 Colorado State University, Fort Collins, CO<br />
and 3 Dow Corning Corporation, Midland, MI.<br />
#856 IMPACT OF MODEL MISSPECIFICATION ON A<br />
PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR DMA. C. R.<br />
Eklund, M. V. Evans and E. M. Kenyon.<br />
ORD/NHEERL/ETD, U. S. EPA, Research Triangle<br />
Park, NC.<br />
#857 HUMAN PBPK MODELING OF CLINICAL CASE<br />
REPORTS OF ETHYLENE GLYCOL<br />
OVERDOSING: INCORPORATION OF<br />
THERAPEUTIC INTERVENTIONS. R. A. Corley 1<br />
and K. E. McMartin 2 . 1 Battelle Northwest, Richland,<br />
WA and 2 Louisiana State University Health Sciences<br />
Center, Shreveport, LA.<br />
#858 DEVELOPMENT OF A PHYSIOLOGICALLY<br />
BASED PHARMACOKINETIC (PBPK) MODEL<br />
TO COMPARE DIFFERENCES IN DISPOSITION<br />
OF TRICHLOROETHYLENE(TCE), AND<br />
METABOLITES IN ADULT VERSUS ELDERLY<br />
RATS. M. V. Evans 1 , R. Tornero-Velez 2 , M. J. DeVito 2 ,<br />
M. Okino 3 , A. Geller 2 , J. Blancato 2 and L. Birnbaum 2 .<br />
1 U.S. EPA/NHEERL, Research Triangle Park, NC,<br />
2 U.S. EPA/NERL, Research Triangle Park, NC and<br />
3 U.S. EPA/NERL, LV, NV.<br />
#859 A PBPK MODEL TO EVALUATE VARIABILITY<br />
IN RENAL CLEARANCE. R. S. DeWoskin 1 and C.<br />
M. Thompson 2 . 1 ORD/NCEA, U.S. EPA, Research<br />
Triangle Park, NC and 2 Risk Policy Fellow / NCEA,<br />
AAAS, Washington, DC.<br />
#860 DEVELOPMENT OF A PHYSIOLOGICALLY<br />
BASED PHARMACOKINETIC MODEL FOR<br />
SCH-D IN THE RAT. G. Pastino 1 , C. Rosenfeld 1,2 , C.<br />
Cox 1 , I. Knemeyer 1 , K. Fellows 1 and L. Sultatos 2 .<br />
1 Schering Plough research Institute, Lafayette, NJ and<br />
2 University <strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey,<br />
Newark, NJ.<br />
#861 PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR ALL-TRANS<br />
RETINOIC ACID IN PREGNANT CD-1 MICE. J.<br />
L. Campbell 1 , D. Warren 2 , M. Smith 1 and J. W. Fisher 1 .<br />
1 Environmental Health Science, University <strong>of</strong> Georgia,<br />
Athens, GA and 2 <strong>Program</strong> in Environmental Science,<br />
University <strong>of</strong> South Carolina-Beaufort, Beaufort, SC.<br />
#862 PREDICTION OF DI-N-BUTYLPHTHALATE<br />
(DBP) LEVELS IN PREGNANT RATS USING A<br />
PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODEL. J. J.<br />
Kremer, R. A. Clewell and S. J. Borgh<strong>of</strong>f. CIIT Centers<br />
for Health Research, Research Triangle Park, NC.<br />
#863 PULMONARY FUNCTION IN RATS DURING<br />
PREGNANCY. T. Leavens, C. Parkinson, A. James, D.<br />
House and D. Dorman. CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
#864 A PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC (PBPK) MODEL FOR THE<br />
PESTICIDE MONOMETHYLARSONIC ACID<br />
(MMA V ). E. M. Kenyon, M. F. Hughes, C. Eklund and<br />
M. V. Evans. U.S. EPA, Research Triangle Park, NC.<br />
#865 DEVELOPMENT OF A HYBRID REACTION<br />
NETWORK-PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC MODEL OF<br />
BENZO(A)PYRENE AND ITS METABOLITES. K.<br />
F. Reardon 1,2 , K. H. Liao 1,2 and R. S. Yang 1 .<br />
1 Quantitative and Computational <strong>Toxicology</strong> Group,<br />
Center for Environmental <strong>Toxicology</strong> and Technology,<br />
Colorado State University, Fort Collins, CO and<br />
2 Department <strong>of</strong> Chemical Engineering, Colorado State<br />
University, Fort Collins, CO.<br />
#866 VALIDATION OF A HUMAN<br />
PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL FOR VINYL<br />
ACETATE AGAINST HUMAN NASAL<br />
DOSIMETRY DATA. P. M. Hinderliter 1 , K. D.<br />
Thrall 2 , R. A. Corley 2 , L. J. Bloemen 3 and B. S.<br />
Matthew 1 . 1 Haskell Laboratory for Health and<br />
Environmental Sciences, Newark, DE, 2 Biological<br />
Sciences Division, Battelle Pacific Northwest<br />
Laboratories, Richland, WA and 3 Epidemiology, Health<br />
Services, Dow Benelux NV, Terneuzen, Netherlands.<br />
#867 DEVELOPMENT AND EVALUATION OF A PBPK<br />
MODEL FOR THE FATE OF 2-<br />
BUTOXYETHANOL IN HUMANS AFTER<br />
DERMAL AND INHALATION EXPOSURE. S.<br />
kezic, J. Kruse and I. Jakasa. Coronel Institute,<br />
Academic Medical Centre, Amsterdam, Netherlands.<br />
Sponsor: P. Boogaard.<br />
#868 PHYSIOLOGICAL MODELING OF THE<br />
TOXICOKINETICS OF METHYL TERT-BUTYL<br />
ETHER (MTBE) AND ITS METABOLITE TERT-<br />
BUTANOL (TBA) IN HUMANS. K. Krishnan 1,3 , A.<br />
Nihlen 2 , L. Ernstgard 3 and G. Johanson 3 . 1 Universite de<br />
Montreal, Montreal, QC, Canada, 2 Active Biotech<br />
Research AB, Lund, Sweden and 3 Work Environment<br />
<strong>Toxicology</strong>, Karolinska Institute, Stockholm, Sweden.<br />
TUESDAY<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#869 A HUMAN DIETARY IODIDE PBPK MODEL TO<br />
EVALUATE THE EFFECTS OF PERCHLORATE<br />
ON THYROIDAL IODIDE CONTENT. J. W.<br />
Fisher 1 , J. L. Campbell 1 and D. Guth 2 . 1 Environmental<br />
Health Science, University <strong>of</strong> Georgia, Athens GA, GA<br />
and 2 The Boeing Company, Seattle, WA.<br />
#870 USE OF A PHYSIOLOGICALLY-BASED<br />
PHARMACOKINETIC MODEL TO ESTIMATE<br />
ABSORBED CARBARYL DOSE IN CHILDREN<br />
AFTER TURF APPLICATION. M. Okino 1 , F. W.<br />
Power 1 , J. B. Knaak 4 , R. Tornero-Velez 2 , C. Lunchick 5 ,<br />
A. Lowit 3 , J. N. Blancato 2 and C. C. Dary 1 .<br />
1 2 NERL\EDRB, U.S. EPA, Las Vegas, NV, NERL, U.S.<br />
EPA, Research Triangle Park, NC, 3 Office <strong>of</strong> Pesticide<br />
<strong>Program</strong>s, U.S. EPA, Washington, DC, 4 Pharmacology<br />
and <strong>Toxicology</strong>, SUNY, Buffalo, Buffalo, NY and<br />
5 Bayer CropScience, Research Triangle Park, NC.<br />
#871 ASSESSING THE RISKS ASSOCIATED WITH<br />
CHILDREN INGESTING LEAD IN SCHOOL<br />
DRINKING WATER: PBPK MODELING AND<br />
RISK COMMUNICATION. M. K. Peterson, R. C.<br />
Pleus and S. M. Hays. Intertox, Inc., Seattle, WA.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: IMMUNOMODULATION<br />
Chairperson(s): Deborah Keil, NIOSH, Morgantown, WV and Ghulam<br />
Ansari, UTMB, Pathology, Galveston, TX.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#872 ENFUVIRTIDE DOES NOT IMPAIR HOST<br />
RESISTANCE TO INFECTIONS IN RATS. T. D.<br />
Steele 1 , W. Geng 1 , F. Burleson 2 and G. Burleson 2 .<br />
1 Nonclinical Drug Safety, H<strong>of</strong>fmann-LaRoche, Inc.,<br />
Nutley, NJ and 2 Burleson Research Technologies,<br />
Raleigh, NC.<br />
#873 EFFECTS OF METHYLPREDNISOLONE ON<br />
CELL PHENOTYPES IN A MURINE CANDIDA<br />
HOST DEFENSE MODEL. C. Maier, C. Genell, A.<br />
Hillegas and D. J. Herzyk. Safety Assessment,<br />
GlaxoSmithKline, King <strong>of</strong> Prussia, PA.<br />
#874 AH RECEPTOR ACTIVATION ELEVATES<br />
INTERFERON GAMMA (IFNγ) AND INDUCIBLE<br />
NITRIC OXIDE SYNTHASE (INOS) LEVELS IN<br />
THE LUNGS OF MICE INFECTED WITH<br />
INFLUENZA A VIRUS. H. Neff-LaFord 1 and B.<br />
Lawrence 2 . 1 Pharmacology/<strong>Toxicology</strong> Graduate<br />
<strong>Program</strong>, Washington State University, Pullman, WA<br />
and 2 Pharmaceutical Sciences, Washington State<br />
University, Pullman, WA.<br />
#875 INCREASED NUMBERS OF NEUTROPHILS IN<br />
TCDD-TREATED MICE INFECTED WITH<br />
INFLUENZA A VIRUS ARE CAUSED BY AN AH<br />
RECEPTOR-MEDIATED MECHANISM THAT IS<br />
LIKELY SPECIFIC TO THE LUNG. S. Teske 1 , A. A.<br />
Bohn 2 and B. Lawrence 1,2 . 1 Pharmacology/<strong>Toxicology</strong><br />
Graduate <strong>Program</strong>, Washington State University,<br />
Pullman, WA and 2 Department <strong>of</strong> Veterinary Clinical<br />
Sciences, Washington State University, Pullman, WA.<br />
#876 ∆9-TETRAHYDROCANNABINOL ALTERS HOST<br />
RESISTANCE TO INFLUENZA A/PR/8<br />
INFECTION IN C57BL/6 MICE. J. P. Buchweitz 1,3 ,<br />
N. E. Kaminski 1,3 and J. R. Harkema 2 . 1 Pharmacology<br />
and <strong>Toxicology</strong>, Michigan State University, East<br />
Lansing, MI, 2 Pathobiology and Diagnostic<br />
Investigation, Michigan State University, East Lansing,<br />
MI and 3 Center for Integrative <strong>Toxicology</strong>, Michigan<br />
State University, East Lansing, MI.<br />
#877 EXPOSURE TO THC, A MARIJUANA<br />
CANNABINOID, INDUCES ALTERATIONS IN<br />
TH1/TH2 CYTOKINE PROFILE RESULTING IN<br />
SUPPRESSION OF IMMUNITY AND INCREASED<br />
SUSCEPTIBILITY TO BREAST CANCER. R.<br />
McKallip 1 , P. S. Nagarkatti 2 and M. Nagarkatti 1 .<br />
1 Department Micro/Immunol, VCU/MCV, Richmond,<br />
VA and 2 Pharmacology and <strong>Toxicology</strong>, VCU/MCV,<br />
Richmond, VA.<br />
#878 IMMUNE FUNCTIONAL AND<br />
HISTOPATHOLOGICAL ALTERATIONS<br />
FOLLOWING EXPOSURE IN FEMALE B6C3F1<br />
MICE TO THE WIDELY USED VEHICLE<br />
ELMIRON® K. L. White Jr. 1 , A. Nyska 2 , R. D.<br />
Brown 1 , D. L. Musgrove 1 , T. L. Guo 1 and D. R.<br />
Germolec 2 . 1 Virginia Commonwealth University,<br />
Richmond, VA and 2 NIEHS, Research Triangle Park,<br />
NC.<br />
#879 INTERACTIONS OF MERCURY WITH LIVER-<br />
STAGE RESPONSES TO MALARIA INFECTION.<br />
J. F. Nyland 1 , A. Lima 1 , G. Mouton 2 , K. West 3 , F.<br />
Zavala 1 and E. Silbergeld 1 . 1 EHS & MMI, Johns<br />
Hopkins, Baltimore, MD, 2 Grambling State, Grambling,<br />
LA and 3 University Hosp <strong>of</strong> West Indies, Kingston,<br />
Jamaica.<br />
#880 THE EFFECTS OF CIGARETTE SMOKE<br />
EXPOSURE AND PREGNANCY ON INNATE AND<br />
ADAPTIVE IMMUNE RESPONSES IN B6C3F1<br />
MICE. E. M. Vancza, S. P. Ng and J. T. Zelik<strong>of</strong>f. New<br />
York University School <strong>of</strong> Medicine, Tuxedo, NY.<br />
#881 SMOKING DURING PREGNANCY REDUCES<br />
IMMUNE TUMOR SURVEILLANCE<br />
MECHANISMS IN THE OFFSPRING: A<br />
TOXICOLOGICAL MODEL. S. P. Ng 1 , A. E.<br />
Silverstone 2 , Z. Lai 2 and J. T. Zelik<strong>of</strong>f 1 . 1 Nelson Institute<br />
<strong>of</strong> Environmental Medicine, New York University<br />
School <strong>of</strong> Medicine, Tuxedo, NY and 2 Department <strong>of</strong><br />
Microbiology & Immunology, SUNY Upstate Medical<br />
University, Syracuse, NY.<br />
116<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#882 GESTATIONAL EXPOSURE TO PFOS<br />
SUPPRESSES IMMUNOLOGICAL FUNCTION IN<br />
F1 MICE. D. E. Keil 1 , T. Mehlman 1 , L. Butterworth 1<br />
and M. M. Peden-Adams 2 . 1 Analytical Sciences Branch,<br />
NIOSH, Morgantown, WV and 2 Department <strong>of</strong><br />
Pediatrics, Medical University <strong>of</strong> South Carolina,<br />
Charleston, SC.<br />
#883 CHANGES IN THE OVINE HYPOTHALAMIC-<br />
PITUITARY-ADRENAL AXIS DURING<br />
PREGNANCY AND LACTATION FOLLOWING<br />
CHALLENGE WITH ESCHERICHIA COLI<br />
LIPOPOLYSACCHARIDE. L. C. Kabar<strong>of</strong>f 1 , N.<br />
Karrow 1 and H. Boermans 2 . 1 Animal and Poultry<br />
Science, University <strong>of</strong> Guelph, Guelph, ON, Canada<br />
and 2 <strong>Toxicology</strong>, University <strong>of</strong> Guelph, Guelph, ON,<br />
Canada.<br />
#884 TETRACHLORODIBENZO-P-DIOXIN (TCDD)<br />
INHIBITS DIFFERENTIATION AND INCREASES<br />
APOPTOTIC CELL DEATH OF PRECURSOR T<br />
CELLS IN THE FETAL MOUSE THYMUS. E.<br />
Besteman, K. Zimmerman, B. Smith and S. Holladay.<br />
Virginia Tech, Blacksburg, VA.<br />
#885 POST-NATAL EXPOSURE OF THE RAT TO<br />
CYCLOSPORINE DOES NOT RESULT IN<br />
PROLONGED IMPAIRMENT OF THE IMMUNE<br />
SYSTEM. J. Descotes 1 , G. Ravel 2 , F. Horand 2 and P.<br />
C. Barrow 2 . 1 Poison Center, Lyon, France and 2 MDS<br />
Pharmacology Services, Saint Germain s/ L’Arbresle,<br />
France.<br />
#886 EFFECT OF TRIBUTYLTIN CHLORIDE ON<br />
NATURAL IMMUNODEFENCES IN THE F1<br />
GENERATION IN MICE. Y. Sugita-Konishi 1 , K.<br />
Kimura 2 , K. Kobayashi 1 , M. Tsunoda 3 and Y. Suzuki 2 .<br />
1 Division <strong>of</strong> Microbiology, National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan, 2 Department <strong>of</strong> Veterinary<br />
Sciences, Azabu University, Sagamihara, Japan and<br />
3 Department <strong>of</strong> Preventive Medicine and Public Health,<br />
Kitazato University, School <strong>of</strong> Medicine, Sagamihara,<br />
Japan.<br />
#887 ALTERED SPLENOCYTE FUNCTIONS IN<br />
FOURTEEN-MONTH OLD MICE PRENATALLY<br />
EXPOSED TO DIETHYLSTILBESTROL. R. M.<br />
Gogal 1,2 , J. Fenaux 1 , D. Lindsay 1 , C. Hardy 1 , D. Ward 1 ,<br />
G. Saunders 1 and S. Ahmed 1 . 1 Biomedical Sciences and<br />
Pathobiology, Va Tech, Blacksburg, VA and 2 Biomecical<br />
Sciences, Via Virginia Colleg <strong>of</strong> Osteopathic medicine,<br />
Blacksburg, VA.<br />
#888 T-CELL MEDIATED IMMUNITY IN ADULT<br />
SPRAGUE-DAWLEY RATS IMPLANTED WITH<br />
DEPLETED URANIUM. L. B. Healey 1 , J. M.<br />
Rutkiewicz 1 , S. R. Lohrke 2 , D. P. Arfsten 2 and K. A.<br />
Grasman 1 . 1 Wright State University, Dayton, OH and<br />
2 Naval Health Research Center Environmental Health<br />
Effects Laboratory, Wright-Patterson AFB, OH.<br />
#889 IMMUNE FUNCTION IN ADULT RATS<br />
EXPOSED TO DBT IN DRINKING WATER. J.<br />
DeWitt 1 , C. Copeland 2 and R. Luebke 2 . 1 Curriculum in<br />
<strong>Toxicology</strong>, UNC, Chapel Hill, NC and<br />
2 NHEERL/ETD/ITB, U.S. EPA, Research Triangle<br />
Park, NC.<br />
#890 IN VIVO AND IN VITRO IMMUNOSUPPRESSIVE<br />
EFFECTS OF 1, 2:5, 6-DIBENZANTHRACENE IN<br />
FEMALE BALB/C MICE. C. Jin 1 , T. Jeon 1 , S. Lee 1 ,<br />
S. Hyun 1 , D. Lee 1 , G. Kim 1 , I. Jun 1 , E. Lee 1 , H. Jeong 2<br />
and T. Jeong 1 . 1 College <strong>of</strong> Pharmacy, Yeungnam<br />
University, Kyungsan, South Korea and 2 College <strong>of</strong><br />
Pharmacy, Chosun University, Gwangju, South Korea.<br />
#891 EVALUATION OF THE IMMUNOMODULATORY<br />
EFFECTS OF DIBENZ(A, H)ANTHRACENE IN<br />
ADULT FEMALE B6C3F1MICE. D. M. Hernandez,<br />
W. Auttachoat, T. L. Guo and K. L. White Jr.. Virginia<br />
Commonwealth University, Richmond, VA.<br />
#892 CYTOCHROME P450 1B1 (CYP1B1) IS<br />
REQUIRED FOR 7, 12-DIMETHYLBENZ(A)-<br />
ANTHRACENE (DMBA) INDUCED SPLEEN<br />
CELL IMMUNOTOXICITY IN C57BL/6N MICE.<br />
J. Gao, S. W. Burchiel, F. T. Lauer and S. Dunaway.<br />
College <strong>of</strong> Pharmacy <strong>Toxicology</strong> <strong>Program</strong>, The<br />
University <strong>of</strong> New Mexico, Albuquerque, NM.<br />
#893 NONCOPLANAR PCB-INDUCED<br />
IMMUNOTOXICITY IN A FISH MODEL IS NOT<br />
AHR-MEDIATED. J. T. Zelik<strong>of</strong>f and J. Duffy.<br />
Department <strong>of</strong> Environmental Medicine, New York<br />
University School <strong>of</strong> Medicine, Tuxedo, NY.<br />
#894 METALLOTHIONEIN INFLUENCES ON<br />
IMMUNE CAPACITY IN METAL-STRESSED<br />
SYSTEMS. K. Zaffuto, D. Unfricht, E. Canpolat, G.<br />
Jin, N. Hadjout, X. Yin and M. A. Lynes. Molecular and<br />
Cell Biology, University <strong>of</strong> Connecticut, Storrs, CT, CT.<br />
#895 THE PARADOXICAL EFFECTS OF LEAD IN<br />
IFNγKNOCKOUT (KO) BALB/C MICE. D. Gao, J.<br />
Kasten-Jolly and D. A. Lawrence. Wadsworth Center,<br />
Albany, NY.<br />
#896 ROLE OF COPPER CHELATION, ALTERATION<br />
OF RED-OX BALANCE, AND STRESS<br />
MEDIATORS IN MODULATION OF CYTOKINE<br />
RESPONSES BY SODIUM<br />
METHYLDITHIOCARBAMATE. S. B. Pruett, C. L.<br />
Schwab, Q. Zheng and R. Fan. Cell. Biol. & Anatomy,<br />
LSU Health Sciences Center, Shreveport, LA.<br />
#897 SODIUM METHYLDITHIOCARBAMATE<br />
SUPPRESSES INNATE IMMUNITY: ROLE OF<br />
TLR SIGNALING AND CYTOKINE<br />
PRODUCTION. C. L. Schwab, Q. Zheng, R. Fan and<br />
S. B. Pruett. Cell. Biol. & Anatomy, LSU Health<br />
Sciences Center, Shreveport, LA.<br />
#898 IDENTIFICATION OF BIOMARKERS FOR<br />
DRUG-INDUCED STRESS: COMPARISON OF<br />
MOUSE AND RAT MODELS. P. Hebert 1 , S. B.<br />
Pruett 1 , J. M. LaPointe 2 and T. T. Kawabata 2 . 1 Cell.<br />
Biol. & Anatomy, LSU Health Sciences Center,<br />
Shreveport, LA and 2 Safety Sciences, Pfizer, Inc.,<br />
Groton, CT.<br />
#899 ROLE OF CORTICOSTERONE IN STRESS-<br />
MEDIATED SUPPRESSION OF TUMOR<br />
RESISTANCE. J. Adams, S. B. Pruett and P. Hebert.<br />
Cell. Biol. & Anatomy, LSU Health Sciences Center,<br />
Shreveport, LA.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 117
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#900 INVESTIGATION OF HABITUATION OR<br />
TOLERANCE IN THE STRESS RESPONSE AND<br />
IMMUNOMODULATORY ACTIONS OF<br />
ETHANOL. Q. Zheng, C. L. Schwab, R. Fan and S. B.<br />
Pruett. Cell. Biol. & Anatomy, LSU Health Sciences<br />
Center, Shreveport, LA.<br />
#901 ACUTE AND CHRONIC EFFECTS OF ETHANOL<br />
ON MACROPHAGES. Q. Dai and S. B. Pruett. Cell.<br />
Biol. & Anatomy, LSU Health Sciences Center,<br />
Shreveport, LA.<br />
#902 EVALUATION OF FLOW CTYOMETRIC<br />
ENDPOINTS FOR THE LYMPH NODE<br />
PROLIFERATION ASSAY (LNPA). J. L. Weaver and<br />
D. Broud. DAPR, U.S. FDA, Silver Spring, MD.<br />
#903 ASSESSMENT OF EARLY IMMUNOLOGICAL<br />
PARAMETERS IN THE POPLITEAL LYMPH<br />
NODE ASSAY TO DETECT<br />
IMMUNOMODULATING DRUGS. R. Pieters 1 , M.<br />
Aalbers 1 , R. Bleumink 1 , L. Boon 2 and S. Nierkens 1 .<br />
1 Immunotoxicology, Institute for Risk Assessment<br />
Sciences, Utrecht, Netherlands and 2 Bioceros BV,<br />
Utrecht, Netherlands.<br />
#904 INVESTIGATING THE MECHANISM OF<br />
NEVIRAPINE-INDUCED SKIN LESIONS IN THE<br />
FEMALE BROWN NORWAY RAT. M. Popovic, J.<br />
M. Shenton and J. P. Uetrecht. Pharmaceutical<br />
Sciences, University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />
#905 ASSOCIATION OF ACETAMINOPHEN-INDUCED<br />
HEPATOTOXICITY WITH<br />
IMMUNOSUPPRESSION. M. Masson 1 , R. Peterson 2 ,<br />
M. L. Graf 1 , C. Chung 1 , D. Krull 2 , J. Sciarrotta 2 , C. W.<br />
Quall 2 , J. L. Ambroso 2 , R. Lightfoot 2 , M. Bourdi 1 and<br />
L. R. Pohl 1 . 1 Molecular and Cellular <strong>Toxicology</strong><br />
Section, LMI, NHLBI, NIH, Bethesda, MD and 2 Safety<br />
Assessment, GlaxoSmithKline, Research Triangle Park,<br />
NC.<br />
#906 ANTIBODIES AGAINST CYP2E1 AFTER<br />
EXPOSURE TO 1, 1, 1-TRIFLUOROETHANE<br />
AND 1, 1, 1, 2-TETRAFLUOROETHANE. S.<br />
Gunnare 1 , M. Vidali 2 , E. Albano 2 and G. Johanson 1 .<br />
1 Work Environment <strong>Toxicology</strong>, Karolinska Institutet,<br />
Stockholm, Sweden and 2 Department <strong>of</strong> Medical<br />
Sciences, University <strong>of</strong> Piedmont, Novara, Italy.<br />
#907 POTENTIAL AUTOIMMUNITY OF<br />
RECOMBINANT MOUSE IL-2 AS A CANCER<br />
THERAPEUTIC AGENT IN TUMOR-BEARING<br />
BALB/C MICE. H. Kim, Y. Cho, J. H. Eom, J. Gil, J.<br />
Lee and K. Park. <strong>Toxicology</strong>, National Institute for<br />
Toxicological Research, Seoul, South Korea. Sponsor:<br />
Y. Heo.<br />
#908 SILICA FAILS TO INDUCE FIBROSIS IN<br />
SCAVENGER RECEPTOR DEFICIENT MICE. C.<br />
A. Beamer and A. Holian. Center for Environmental<br />
Health Sciences, University <strong>of</strong> Montana, Missoula, MT.<br />
#909 COMPARISON OF CHLORDECONE AND<br />
ESTROGEN EFFECTS ON PHENOTYPIC<br />
MARKERS ON IMMUNOCYTES. F. Wang 1,2 , S. M.<br />
Roberts 1,3 and E. S. Sobel 2 . 1 Depts <strong>of</strong> Pharmacology<br />
and Therapeutics, University <strong>of</strong> Florida, Gainesville,<br />
FL, 2 College <strong>of</strong> Medicine, University <strong>of</strong> Florida,<br />
Gainesville, FL and 3 Physiological Sciences, University<br />
<strong>of</strong> Florida, Gainesville, FL.<br />
#910 ADAPTATION OF THE SYSTEMIC LUPUS<br />
ERYTHREMATOSUS PRONE (NZB X NZW)F1<br />
MOUSE STRAIN FOR AUTOIMMUNE<br />
TOXICOLOGY EVALUATION. S. P. Keegan, K. L.<br />
Nadwodny, B. A. Speal, D. J. Herzyk and J. M. Soos.<br />
Safety Assessment, GlaxoSmithKline, King <strong>of</strong> Prussia,<br />
PA.<br />
#911 ASBESTOS-INDUCED AUTOIMMUNITY IN<br />
C57BL/6 MICE. J. C. Pfau, J. Sentissi, R. Thompson<br />
and C. MacKenzie. Ctr for Environ Health<br />
Sciences/Biomed Pharmacology Sciences, University <strong>of</strong><br />
Montana, Missoula, MT.<br />
#912 IMMUNOTOXICITY OF DICHLOROACETYL<br />
CHLORIDE AND DICHLOROACETIC<br />
ANHYDRIDE IN FEMALE MRL +/+ MICE. G.<br />
Ansari, P. Cai, M. F. Khan and B. S. Kaphalia.<br />
pathology, UTMB, Galveston, TX.<br />
#913 IMMUNOTOXICITY OF OLEIC ACID ANILIDE<br />
AND ITS HYDROLYSIS PRODUCTS IN FEMALE<br />
MRL +/+ MICE. P. Cai, M. F. Khan, B. S. Kaphalia<br />
and G. S. Ansari. Pathology, UTMB, Galveston, TX.<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RESPIRATORY TRACT II<br />
Chairperson(s): Joel Pounds, Batelle NW, Richland, WA and Matthew<br />
Campen, Lovelace, Albuquerque, NM.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#914 A RESPIRATORY SAFETY PHARMACOLOGY<br />
ASSESSMENT OF HYDROCODONE<br />
BITARTRATE AND NALTREXONE<br />
HYDROCHLORIDE. K. Hew 1 , S. Mason 2 and H.<br />
Penton 2 . 1 Safety Assessment, Purdue Pharmacology<br />
L.P., Ardsley, NY and 2 Safety Pharmacology, CTBR<br />
Bio-Research Inc., Senneville, NY.<br />
#915 PARTICLE OVERLOAD IN RAT LUNG<br />
FOLLOWING INHALATION TO A POORLY<br />
SOLUBLE COMPOUND. S. Holt 1 , M. Pino 1 , N.<br />
Barlow 1 , E. Orton 2 and T. M. Monticello 1 . 1 Drug Safety<br />
& Evaluation, san<strong>of</strong>i-aventis, Bridgewater, NJ and<br />
2 GPD/Pharmaceutical Sciences, san<strong>of</strong>i-aventis,<br />
Bridgewater, NJ.<br />
118<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#916 ALTERED SUSCEPTIBILITY TO 1-<br />
NITRONAPHTHALENE OF RAT NASAL<br />
MUCOSA AFTER CHRONIC OZONE<br />
EXPOSURE. M. G. Lee 1 , A. M. Wheelock 2 , M. V.<br />
Fanucchi 1 , A. R. Buckpitt 2 and C. G. Plopper 1 .<br />
1 2 VM:APC, UC Davis, Davis, CA and VM:MB, UC<br />
Davis, Davis, CA.<br />
#917 QUANTITATION OF AIRWAY SPECIFIC GENE<br />
EXPRESSION OF ENDOTHELIN-1 AND IT’S<br />
RECEPTORS DURING NAPHTHALENE INJURY<br />
AND REPAIR IN THE ADULT MOUSE LUNG. G.<br />
L. Baker, K. L. Sutherland, C. D. Brown, C. G. Plopper<br />
and L. S. Van Winkle. VM: APC, UC Davis, Davis, CA.<br />
#918 PROTEOMIC CHARACTERIZATION OF<br />
BRONCHOALVEOLAR LAVAGE FLUID (BALF),<br />
LUNG, AND SERUM IN A MOUSE EMPHYSEMA<br />
MODEL INDUCED BY ELASTASE. J. N. Adkins 1 ,<br />
R. C. Barry 1 , M. E. Monroe 1 , R. D. Smith 1 , K. Lee 2 and<br />
J. G. Pounds 1 . 1 Battelle, Pacific Northwest National<br />
Laboratory, Richland, WA and 2 Battelle, <strong>Toxicology</strong><br />
Northwest Division, Richland, WA.<br />
#919 CHARACTERIZATION OF ELASTASE-INDUCED<br />
EMPHYSEMA IN MOUSE LUNG PER<br />
HISTOPATHOLOGY, MORPHOMETRY, AND<br />
BRONCHOALVEOLAR LAVAGE (BAL)<br />
MEASUREMENTS. K. M. Lee 1 , Q. Meng 1 , R. A.<br />
Renne 1 , K. M. Gideon 1 , S. J. Harbo 1 , J. T. Pierce 1 , L. A.<br />
Wisse 1 and J. G. Pounds 2 . 1 Battelle <strong>Toxicology</strong> NW,<br />
Richland, WA and 2 Pacific Northwest National<br />
Laboratories, Richland, WA.<br />
#920 THE USE OF LUNG MECHANICS FOR THE<br />
PHENOTYPING OF LUNG RESPONSES TO<br />
CIGARETTE SMOKE EXPOSURE IN MICE. M.<br />
G. Cosio 2 and T. F. Schuessler 1 . 1 SCIREQ Inc.,<br />
Montreal, QC, Canada and 2 Meakins-Christie Labs,<br />
McGill University, Montreal, QC, Canada. Sponsor: N.<br />
Sponsor.<br />
#921 EVALUATION OF RELATIVE CONTRIBUTIONS<br />
OF VAPOR PHASE AND PARTICULAR MATTER<br />
TO THE TOTAL CYTOTOXICITY OF<br />
CIGARETTE SMOKE. R. Meng, M. Clark, K.<br />
Hitchman and L. Wisse. Battelle, Richland, WA.<br />
Sponsor: K. lee.<br />
#922 LUNG INFLAMMATION IN RATS AFTER<br />
ACUTE EXPOSURE TO CIGARETTE SMOKE. P.<br />
Vanscheeuwijck 1 , E. Van Miert 1 and B. Friedrichs 2 .<br />
1 PHILIP MORRIS Research Laboratories bvba, Leuven,<br />
Belgium and 2 PHILIP MORRIS Research Laboratories<br />
GmbH, Cologne, Germany. Sponsor: H. Haussmann.<br />
#923 FOCAL PROLIFERATIVE LESIONS IN A/J<br />
MOUSE LUNG FOLLOWING 5-MONTH<br />
EXPOSURE TO CIGARETTE MAINSTREAM<br />
SMOKE. J. T. Hamm 1 , S. Yee 1 , N. Rajendran 2 , R. L.<br />
Morrissey 3 and M. Misra 1 . 1 Lorillard Tobacco<br />
Company, Greensboro, NC, 2 IIT Research Institute,<br />
Chicago, IL and 3 PAI, Chicago, IL. Sponsor: C. Smith.<br />
#924 INFLUENCE OF SUB-CHRONIC CIGARETTE<br />
SMOKE EXPOSURE ON THE PROGRESSION OF<br />
MYOCARDIAL HYPERTROPHY IN<br />
SPONTANEOUSLY HYPERTENSIVE RATS<br />
(SHR). K. von Holt 1 , K. Schlueter 2 , S. Ruf 2 , K.<br />
Meurrens 3 and R. Schleef 1 . 1 PHILIP MORRIS Research<br />
Laboratories GmbH, Cologne, Germany, 2 Justus-Liebig-<br />
University, Giessen, Germany and 3 PHILIP MORRIS<br />
Research Laboratories bvba, Leuven, Belgium. Sponsor:<br />
H. Haussmann.<br />
#925 CIGARETTE SMOKE ENHANCES ENDOTOXIN-<br />
INDUCED PULMONARY INFLAMMATION. G.<br />
Kulkarni, P. Nadkarni, J. M. Cerreta and J. O. Cantor.<br />
Department <strong>of</strong> Pharmaceutical Sciences, Saint John’s<br />
University, Jamaica, NY. Sponsor: L. Trombetta.<br />
#926 TETRAHYDROCANNABINOL CAUSES<br />
PULMONARY CELL MITOCHONDRIAL INJURY<br />
IN VITRO AND IN VIVO. T. A. Sarafian 1 , N. Habib 1 ,<br />
M. J. Oldham 2 , N. Seeram 1 , R. Lee 1 , D. P. Tashkin 1 and<br />
M. D. Roth 1 . 1 Medicine, UCLA, Los Angeles, CA and<br />
2 Community and Environmental Medicine, UC Irvine,<br />
Irvine, CA.<br />
#927 SPONTANEOUSLY HYPERTENSIVE RATS ARE<br />
SUSCEPTIBLE TO AIRWAY DISEASE INDUCED<br />
BY SULFUR DIOXIDE. M. C. Schladweiler 1 , A. D.<br />
Ledbetter 1 , D. L. Costa 1 , K. E. Pinkerton 2 , J. H.<br />
Richards 1 , P. Evansky 1 and U. P. Kodavanti 1 .<br />
1 2 NHEERL/ETD/PTB, U.S. EPA, Durham, NC and UC<br />
Davis, Davis, CA.<br />
#928 HOST-DEPENDENT INCREASE IN LUNG<br />
EPITHELIAL MEMBRANE PERMEABILITY<br />
AFTER O3. E. McElvania TeKippe, K. G. Berman, J.<br />
W. Hollingsworth II, D. A. Schwartz and W. Foster.<br />
Pulmonary, Allergy, and Critical Care, Duke University,<br />
Durham, NC.<br />
#929 EVALUATION OF THE SENSITIVITY TO<br />
INHALED OXIDANTS IN CSB MICE. I. M.<br />
Kooter 1 , P. H. Fokkens 1 , D. L. Leseman 1 , J. F. Boere 1 ,<br />
M. E. Gerl<strong>of</strong>s-Nijland 1 , H. van Steeg 2 and F. R.<br />
Cassee 1 . 1 MGO, RIVM, Bilthoven, Netherlands and<br />
2 TOX, RIVM, Bilthoven, Netherlands. Sponsor: H. van<br />
Loveren.<br />
#930 ZINC DEFICIENCY ENHANCES PRO-<br />
INFLAMMATORY RESPONSES AFTER OZONE<br />
EXPOSURE. I. Jaspers 1,3 , K. A. Bridge 2 , M. Doyle 2 ,<br />
K. Sexton 2 , E. Ho 4 , M. Styblo 3 and H. Jeffries 2 .<br />
1 CEMALB, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC, 2 ESE, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC, 3 Pediatrics, University <strong>of</strong> North Carolina, Chapel<br />
Hill, NC and 4 Nutrition, Oregon State University,<br />
Corvallis, OR.<br />
#931 MECHANISMS REGULATING ACTIVATION OF<br />
MACROPHAGES IN THE LUNG FOLLOWING<br />
OZONE INHALATION. A. Conner 1,3 , J. D. Laskin 2,3<br />
and D. L. Laskin 1,3 . 1 Pharmacology and <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ, 2 Environmental and<br />
Occupational Medicine, UMDNJ-Robert W Johnson<br />
Med. Sch, Piscataway, NJ and 3 Joint Graduate <strong>Program</strong><br />
in <strong>Toxicology</strong>, Rutgers University, Piscataway, NJ.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 119
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#932 3β-HYDROXY-5-OXO-5, 6-SECOCHOLESTAN-6-<br />
AL, A MAJOR OZONIZATION PRODUCT OF<br />
CHOLESTEROL, INDUCES APOPTOSIS IN<br />
CARDIOMYOCYTES. M. Haque 1 , I. Sehgal 1 , S.<br />
Murthy 2 , J. Francis 1 and R. Uppu 3 . 1 LSU School <strong>of</strong><br />
Veterinary Medicine, Baton Rouge, LA, 2 Tulane<br />
University Health Sciences Center, New Orleans, LA<br />
and 3 Southern University, Baton Rouge, LA.<br />
#933 INCREASED SUSCEPTIBILITY OF<br />
HYPERTHYROID RATS TO OZONE: EARLY<br />
EVENTS AND MECHANISMS. L. Huffman 1,2 , C.<br />
Beighley 3 , D. Frazer 1,2 , W. McKinney 1 and D. Porter 1,2 .<br />
1 2 PPRB, NIOSH, Morgantown, WV, Physiology and<br />
Pharmacology, West Virginia University, Morgantown,<br />
WV and 3 Biostatistics, NIOSH, Morgantown, WV.<br />
#934 INHIBITION OF TRANSFORMING GROWTH<br />
FACTOR BETA MNRA TRANSCRIPTION BY<br />
ANTISENSE OLIGONUCLEOTIDES IN<br />
AMIODARONE TREATED HAMSTERS. H.<br />
conway, U. doshi and J. M. cerreta. Department <strong>of</strong><br />
Pharmaceutical Sciences, St. John’s University, Jamaica,<br />
NY.<br />
#935 INVESTIGATION OF PREVENTION OF<br />
AMIODARONE- AND<br />
DESETHYLAMIODARONE-INDUCED<br />
TOXICITY IN HUMAN PERIPHERAL LUNG<br />
EPITHELIAL CELLS HPL1A. A. C. Nicolescu, J. F.<br />
Brien, W. J. Racz and T. E. Massey. Pharmacology &<br />
<strong>Toxicology</strong>, Queen’s University, Kingston, ON, Canada.<br />
#936 GENE MICROARRAY ANALYSIS IN A RAT<br />
MODEL OF SMOKE INHALATION-INDUCED<br />
ACUTE LUNG INJURY. S. S. Wong 1 , N. N. Sun 1 , C.<br />
D. Fastje 1 , R. Lantz 2 and M. L. Witten 1 . 1 Center for<br />
<strong>Toxicology</strong> & Department <strong>of</strong> Pediatrics, The University<br />
<strong>of</strong> Arizona, Tucson, AZ and 2 Center for <strong>Toxicology</strong> &<br />
Department <strong>of</strong> Cell Biology/Anatomy, The University<br />
<strong>of</strong> Arizona, Tucson, AZ.<br />
#937 EXPRESSION AND CHARACTERIZATION OF<br />
TRPM8 RECEPTORS IN THE LUNG<br />
EPITHELIUM. A. S. Sabnis, M. E. Johansen, G. S.<br />
Yost and C. A. Reilly. Pharmacology & <strong>Toxicology</strong>,<br />
University <strong>of</strong> Utah, Salt Lake City, UT.<br />
#938 AEROSOLIZED HYALURONAN MODIFIES<br />
ENDOTOXIN-INDUCED LUNG INJURY IN A<br />
TIME-DEPENDENT MANNER. P. Nadkarni, G.<br />
Kulkarni and J. Cantor. Pharmacy and Allied Health<br />
Pr<strong>of</strong>essions, St John’s University, New York. Sponsor:<br />
L. Trombetta.<br />
#939 IMMUNE RESPONSE TO ZYMOSAN-INDUCED<br />
PULMONARY INFLAMMATION IN RATS. S.<br />
Young, J. R. Roberts and J. M. Antonini. NIOSH,<br />
Morgantown, WV.<br />
#940 HYDROGEN SULFIDE EXPOSURE CAUSES<br />
INTRACELLULAR ACIDIFICATION OF RAT<br />
NASAL RESPIRATORY EPITHELIAL CELLS. E.<br />
S. Roberts, V. A. Wong, B. E. McManus and D. C.<br />
Dorman. CIIT Centers for Health Research, Research<br />
Triangle Park, NC.<br />
#941 PERTURBATION OF COPPER HOMEOSTASIS<br />
AND EXPRESSION OF COPPER-BINDING<br />
PROTEINS IN CADMIUM-RESISTANT LUNG<br />
FIBROBLASTS. D. K. Chou 1 , Y. Zhao 1 , S. Gao 1 , L.<br />
Chen 1 , I. Chou 2 , P. Toselli 1 , P. Stone 1 and W. Li 1 .<br />
1 Biochemistry, Boston University School <strong>of</strong> Medicine,<br />
Boston, MA and 2 Microbiology, Boston University<br />
School <strong>of</strong> Medicine, Boston, MA.<br />
#942 PHOTOCHEMICAL REACTIONS ENHANCE<br />
INFLAMMATORY RESPONSES IN HUMAN<br />
LUNG CELLS. M. Doyle 1 , K. G. Sexton 1 , H. Jeffries 1 ,<br />
K. Lichtveld 1 and I. Jaspers 2,1 . 1 ESE, UNC-CH, Chapel<br />
Hill, NC and 2 CEMALB, UNC-CH, Chapel Hill, NC.<br />
#943 INHALATION EXPOSURE TO TERTIARY AMYL<br />
METHYL ETHER (TAME) ALTERS THE<br />
ACTIVITIES OF CYTOCHROME P450<br />
ISOZYMES IN HEPATIC AND RESPIRATORY<br />
TISSUES OF SPRAGUE DAWLEY RATS. J. L.<br />
Weissert and R. A. Schatz. <strong>Toxicology</strong>, Northeastern<br />
University, Boston, MA.<br />
#944 BIOPERSISTENCE OF ROCK WOOL (RW) IN<br />
THE RAT LUNG AFTER SHORT-TERM<br />
INHALATION VIA NOSE. Y. Kudo, Y. Sugiura, M.<br />
Tsunoda, T. Satoh and Y. Aizawa. Department <strong>of</strong><br />
Preventive Medicine and Public Health, Kitasato<br />
University School <strong>of</strong> Medicine, Sagamihara, Japan.<br />
#945 TWO-WEEK INHALATION STUDIES WITH<br />
DISK-SHAPED PARTICLES OF POTASSIUM<br />
TITANATE COMPOUNDS: TERRACESS PS AND<br />
TERRACESS LS. S. Sakai 1 , K. Inada 1 , A. K. Tanaka 1 ,<br />
D. P. Kelly 3 , G. Sykes 3 and K. P. Lee 4 . 1 Otsuka<br />
Chemical Co. Ltd., Osaka, Japan, 2 DuPont Haskell<br />
Laboratory, Newark, DE, 3 Veterinary Pathology<br />
Services, West Grove, PA and 4 Pathology Consulting,<br />
Newark, DE.<br />
#946 CHRONIC LUNG TOXICITY IN RATS DUE TO<br />
EXPOSURE TO DIFFERENT<br />
CONCENTRATIONS OF THE MINERAL OIL. F.<br />
S. Abouzakhar 1,2,3 . 1 Electrical Eng., Al-Tahadi<br />
University, Sirt, Libya, 2 Forensic Med.& <strong>Toxicology</strong>, El<br />
Minia University, El Minia, Egypt, 3 Pharmacology &<br />
Therapeutics, Ain Shams University, Ain Shams, Egypt<br />
and 4 Internal Medicine, Al-Tahady University, Sirt,<br />
Libya. Sponsor: F. Abouzakhar.<br />
#947 SENSORY IRRITATION RESPONSE TO ATP, α, β-<br />
METHYLENE-ATP AND ADENOSINE<br />
AEROSOLS. W. S. Wilkie and J. B. Morris.<br />
<strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong> Connecticut, Storrs,<br />
CT.<br />
120<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: REPRODUCTION AND DEVELOPMENT<br />
Chairperson(s): Wendy Koch, Epona Associates LLC, Willington, CT and Eve<br />
Mylchreest, DuPont Haskell Laboratories, Newark, DE.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#948 EFFECTS OF GROUP HOUSING ON<br />
REPRODUCTIVE PARAMETERS IN THE<br />
SEXUALLY MATURE CYNOMOLGUS MONKEY.<br />
G. Weinbauer 1 , M. Nieh<strong>of</strong>f 1 , M. Bergmann 2 and W.<br />
Mueller 1 . 1 Covance Laboratories GmbH, 48163<br />
Muenster, Germany and 2 Institute <strong>of</strong> Veterinary<br />
Anatomy, University <strong>of</strong> Giessen, 35392 Giessen,<br />
Germany.<br />
#949 28-DAY INHALATION AND<br />
REPRODUCTIVE/DEVELOPMENTAL<br />
SCREENING TOXICITY STUDIES OF<br />
TETRAMETHYLSILANE IN SPRAGUE-DAWLEY<br />
RATS. W. Siddiqui 1 , L. Meeker 1 , J. Tobin 1 , J.<br />
Crissman 1 , J. Knochel 1 , S. Cr<strong>of</strong>oot 1 , G. Burin 2 and K.<br />
Plotzke 1 . 1 Health and Environmental Sciences, Dow<br />
Corning Corporation, Midland, MI and 2 <strong>Toxicology</strong><br />
Division, Technology Sciences Group, Washington, DC.<br />
#950 GLYCIDOXYPROPYLTRIMETHOXYSILANE<br />
(TMSPGE): ONE-GENERATION<br />
REPRODUCTION STUDY IN THE RAT. W. H.<br />
Koch 1 and H. Becker 2 . 1 Epona Associates, LLC,<br />
Willington, CT and 2 <strong>Toxicology</strong>/Safety Assessment 1,<br />
RCC Ltd., Fullinsdorf, Switzerland.<br />
#951 DEVELOPMENTAL TOXICITY AND COMBINED<br />
MALE AND FEMALE FERTILITY STUDIES IN<br />
RATS EXPOSED TO 2, 3-DICHLORO-1, 3-<br />
BUTADIENE (DCBD) BY INHALATION. L. A.<br />
Malley, E. Mylchreest, A. O. O’Neill, T. A. Kegelman,<br />
G. P. Sykes and R. Valentine. DuPont Haskell<br />
Laboratory, Newark, DE.<br />
#952 LACK OF FERTILITY OR ESTROUS CYCLE<br />
EFFECTS OF A FLUORINATED ORGANIC<br />
ETHOXYLATE SURFACTANT IN RATS. J. M.<br />
Lewis 1 , E. Mylchreest 1 , S. R. Frame 1 , R. C. Buck 2 and<br />
J. C. Stadler 1 . 1 DuPont Haskell Laboratory, Newark,<br />
DE and 2 DuPont, Wilmington, DE.<br />
#953 DEVELOPMENTAL IMMUNOTOXICITY OF<br />
DEXAMETHASONE AND CYCLOSPORIN A. I. D.<br />
Waalkens-Berendsen, A. P. Wolterbeek, A. Dijkstra, F.<br />
C. Kuper, A. H. Penninks, M. Zijverden van, E. I. Klein<br />
Koerkamp, P. T. Berg van den and M. M. Tegelenbosch.<br />
<strong>Toxicology</strong> and Applied Pharmacology, TNO Nutrition<br />
and Food Research, Zeist, Netherlands. Sponsor: V.<br />
Feron.<br />
#954 BEHAVIORAL ABNORMALITY ASSOCIATED<br />
WITH ATTENTION DEFICIT HYPERACTIVE<br />
DISORDER IN RAT OFFSPRING PRENATALLY<br />
EXPOSED TO 5-BROMO-2’-DEOXYURIDINE. K.<br />
Orito 1 , M. Kuwagata 2 , T. Ogawa 3 , K. Muneoka 3 , M.<br />
Shirai 1 , F. Akahori 1 , K. Mishima 4 and M. Fujiwara 4 .<br />
1 Pharmacology, Azabu university School <strong>of</strong> Veterinary<br />
Medicine, Sagamihara, Japan, 2 Hatano Research<br />
Institute, FDSC, Hadano, Japan, 3 Anatomy I, Showa<br />
University School <strong>of</strong> Medicine, Tokyo, Japan and<br />
4 Neuropharmacology, Faculty <strong>of</strong> Pharmaceutical<br />
Sciences, Fukuoka University, Fukuoka, Japan.<br />
#955 MATERNAL DETOXICATION VIA CYP1A1<br />
PREVENTS METABOLIC ACTIVATION AND<br />
EMBRYO TOXICITY FOLLOWING ORAL<br />
EXPOSURE TO BENZO(A)PYRENE. C. P. Curran 1 ,<br />
M. L. Miller 1 , N. Dragin 1 , T. P. Dalton 1 , D. W. Nebert 1<br />
and S. Uno 2 . 1 University <strong>of</strong> Cincinnati Medical Center,<br />
Cincinnati, OH and 2 Nihon University School <strong>of</strong><br />
Medicine, Tokyo, Japan.<br />
#956 MATURATION OF HEPATIC CYTOCHROME<br />
P450 ISOZYMES IN DEVELOPING SPRAGUE-<br />
DAWLEY RATS. B. McPhail, S. Muralidhara, S.<br />
Anand and J. Bruckner. Pharmaceutical and Biomedical<br />
Sciences, University <strong>of</strong> Georgia, Athens, GA.<br />
#957 RESISTANCE TO PCB INDUCTION OF P450 1A<br />
(CYP1A) ACTIVITY AND REACTIVE OXYGEN<br />
SPECIES (ROS) PRODUCTION IN A POLLUTED<br />
KILLIFISH (FUNDULUS HETEROCLITUS)<br />
POPULATIONS. X. Arzuaga 1 and A. A. Elskus 2 .<br />
1 <strong>Toxicology</strong>, University <strong>of</strong> Kentucky, Lexington, KY<br />
and 2 Department <strong>of</strong> Biological Sciences, USGS, Orono,<br />
ME. Sponsor: B. Hennig.<br />
#958 SUB-CHRONIC SODIUM ARSENATE EXPOSURE<br />
AFFECTS FERTILITY AND EARLY<br />
DEVELOPMENT IN HOMING PIGEONS: A<br />
MODEL FOR MIGRATORY BIRDS. J. Brasel 1 , A.<br />
C. Collier 2 and C. A. Pritsos 2,1 . 1 Environmental<br />
Sciences and Health <strong>Program</strong>, University <strong>of</strong> Nevada,<br />
Reno, NV and 2 Nutrition, University <strong>of</strong> Nevada, Reno,<br />
NV.<br />
#959 TRUE HERMAPHRODITISM IN A CD-1 MOUSE.<br />
A. Moran. Covance Laboratories Ltd., Harrogate,<br />
United Kingdom. Sponsor: D. Everett.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 121
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
Tuesday Morning, March 8<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: DEVELOPMENTAL NEUROTOXICITY I<br />
Chairperson(s): Russell Carr, Mississippi State University, Mississippi State,<br />
MS and Bernie Jortner, Virginia Tech, Blacksburg, VA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#960 CIGARETTE SMOKE INHALATION IN<br />
JUVENILE RATS: A POTENTIAL ANIMAL<br />
MODEL OF ADOLESCENT NICOTINE<br />
ADDICTION. T. F. Murray 1 , J. M. Benson 2 , E. B.<br />
Barr 2 , J. McDonald 2 , M. D. Campen 2 , X. Yan 1 and C. S.<br />
Hale 1 . 1 Physiology and Pharmacology, University <strong>of</strong><br />
Georgia, Athens, GA and 2 Lovelace Biomedical and<br />
Environmental Institute, Albuquerque, NM.<br />
#961 “SENSORIMOTOR PERFORMANCE DEFICITS,<br />
NEURONAL CELL LOSS, AND ELEVATED<br />
GLIAL ACIDIC PROTEIN EXPRESSION IN<br />
PURKINJE CELLS AND CA1 OF THE<br />
HIPPOCAMPUS IN ADULT OFFSPRING<br />
FOLLOWING MATERNAL EXPOSURE TO<br />
NICOTINE”. W. A. Khan, A. M. Dechkovskaia, A. A.<br />
Rahman, X. Guan and M. B. Abou-Donia.<br />
Pharmacology and Cancer Biology, Duke University<br />
Medical Center, Durham, NC.<br />
#962 “INCREASED EXPRESSION OF GLIAL<br />
FIBRILLARY ACIDIC PROTEIN IN THE MOTOR<br />
CORTEX AND HIPPOCAMPUS, AND<br />
NEUROBEHAVIORAL DEFICITS IN THE<br />
OFFSPRING FOLLOWING GESTATIONAL<br />
EXPOSURE TO IMIDACLOPRID”. A. A. Abdel-<br />
Rahman, A. M. Dechkovskaia, J. M. Sutton, T. Tu, W.<br />
A. Khan and M. B. Abou-Donia. Pharmacology and<br />
Cancer Biology, Duke University Medical Center,<br />
Durham, NC.<br />
#963 NONCHOLINESTERASE MECHANISM(S) OF<br />
CHLORPYRIFOS NEUROTOXICITY<br />
INDICATED BY GENE EXPRESSION PROFILES<br />
OF RAT BRAIN TISSUE. A. R. Stapleton 1 , N.<br />
DelRaso 2 and V. Chan 1 . 1 ManTech Environmental<br />
Technology, Inc., Wright-Patterson AFB, Dayton, OH<br />
and 2 Applied Biotechnology Branch, Human<br />
Effectiveness Directorate, Air Force Research<br />
Laboratory, Wright-Patterson AFB, Dayton, OH.<br />
Sponsor: J. Gearhart.<br />
#964 OXIDATIVE MECHANISMS CONTRIBUTING<br />
TO THE DEVELOPMENTAL NEUROTOXICITY<br />
OF NICOTINE AND CHLORPYRIFOS. D. Qiao, F.<br />
J. Seidler and T. A. Slotkin. Pharmacology & Cancer<br />
Biology, Duke University Med. Ctr, Durham, NC.<br />
#965 DEVELOPMENTAL CHLORPYRIFOS<br />
EXPOSURE TARGETS SEROTONIN FUNCTION<br />
AND RELATED BEHAVIORS. J. E. Aldridge, E. D.<br />
Levin, F. J. Seidler and T. A. Slotkin. Pharmacol/Cancer<br />
Biol, Duke U Med. Ctr, Durham, NC.<br />
#966 YOUNG ANIMALS ARE DEFICIENT IN BOTH<br />
HEPATIC P450 AND CARBOXYLESTERASE<br />
DETOXIFICATION OF DELTAMETHRIN, A<br />
PYRETHROID PESTICIDE. W. T. Haines 1,2 , R. S.<br />
Marshall 2 , D. L. Hunter 2 and S. Padilla 2 . 1 Curriculum<br />
in <strong>Toxicology</strong>, University <strong>of</strong> NC at Chapel Hill, Chapel<br />
Hill, NC and 2 Neurotoxicology Division, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#967 EFFECT OF ORGANOPHOSPHORUS<br />
INSECTICIDES AND THEIR METABOLITES ON<br />
DNA SYNTHESIS IN ASTROGLIAL CELLS. M.<br />
Guizzetti, S. Pathak, G. Giordano and L. G. Costa.<br />
EOHS, University <strong>of</strong> Washington, Seattle, WA.<br />
#968 PON1 MODULATES OP TOXICITY DURING<br />
DEVELOPMENT. C. Pettan-Brewer 1 , T. B. Cole 1,2,3 ,<br />
J. Fisher 3 , B. Walter 3 , A. Forbes 3 , N. Yee 1 , L. G. Costa 3<br />
and C. E. Furlong 1,2 . 1 Medical Genetics, University <strong>of</strong><br />
Washington, Seattle, WA, 2 Genome Sciences,<br />
University <strong>of</strong> Washington, Seattle, WA and<br />
3 Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Washington, Seattle, WA.<br />
#969 REPEATED EARLY POSTNATAL EXPOSURE TO<br />
CHLORPYRIFOS AFFECTS WORKING<br />
MEMORY PERFORMANCE IN THE 12-ARM<br />
RADIAL MAZE. F. O. Johnson, J. E. Chambers and R.<br />
L. Carr. Center For Environmental Health Sciences,<br />
College <strong>of</strong> Veterinary Medicine, Mississippi State<br />
University, Starkville, MS.<br />
#970 DISRUPTION OF PERFORMANCE IN THE 12-<br />
ARM RADIAL MAZE IN RATS EXPOSED TO<br />
METHYL PARATHION DURING THE EARLY<br />
POSTNATAL PERIOD. R. L. Carr, J. E. Chambers<br />
and F. Johnson. Center for Environmental Health<br />
Sciences, College <strong>of</strong> Veterinary Medicine, Mississippi<br />
State University, Mississippi State, MS.<br />
#971 NGF GENE EXPRESSION AND PROTEIN<br />
LEVELS IN THE JUVENILE HIPPOCAMPUS<br />
AFTER REPEATED EXPOSURE TO<br />
CHLORPYRIFOS AND METHYL PARATHION. A.<br />
M. Betancourt, S. C. Burgess and R. L. Carr. Center for<br />
Environmental Health Sciences, College <strong>of</strong> Veterinary<br />
Medicine, Mississippi State University, Mississippi<br />
State, MS.<br />
#972 EFFECTS OF POSTNATAL TREATMENT WITH<br />
CHLORPYRIFOS AND METHYL PARATHION<br />
ON CHOLINERGIC PARAMETERS IN RAT<br />
BRAIN REGIONS. S. Guo-Ross, J. A. Dobbs, M. B.<br />
Dail and J. E. Chambers. Center for Environmental<br />
Health Sciences, Mississippi State University,<br />
Mississippi State, MS.<br />
#973 DEVELOPMENTAL PYRETHROID EXPOSURE<br />
ALTERS DOPAMINERGIC NEUROCHEMISTRY<br />
RESULTING IN HYPERACTIVITY AND<br />
ENHANCED TOXICITY OF MPTP. J. R.<br />
Richardson, T. S. Guillot, M. Caudle, M. Z. Wang and<br />
G. W. Miller. Center for Neurodegenerative Disease and<br />
Department <strong>of</strong> Environmental and Occupational Health,<br />
Rollins School <strong>of</strong> Public Health, Emory University,<br />
Atlanta, GA.<br />
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<strong>Program</strong> Description<br />
#974 NEONATAL EXPOSURE TO NICOTINE<br />
INDUCES INCREASED SUSCEPTIBILITY TO<br />
PARAOXON EXPOSURE AT ADULT AGE. E.<br />
Ankarberg, A. Fredriksson and P. Eriksson. Department<br />
<strong>of</strong> Environmental <strong>Toxicology</strong>, Uppsala University,<br />
Uppsala, Sweden.<br />
#975 NEONATAL EXPOSURE TO A SINGLE LOW<br />
DOSE OF A TYPE I PYRETHROID<br />
(BIOALLETHRIN) AFFECTS SPONTANEOUS<br />
BEHAVIOR AND LEARNING IN ADULT MICE<br />
OF DIFFERENT STRAINS. C. Fischer, A.<br />
Fredriksson and P. Eriksson. Department <strong>of</strong><br />
Environmental <strong>Toxicology</strong>, Uppsala University,<br />
Uppsala, Sweden.<br />
#976 STRUCTURAL IMPACT OF DIAZINON AND<br />
MOLINATE ON NEURITE OUTGROWTH IN<br />
N1E-115 CELLS. D. T. Edge 1 , R. D. Cannady 2 , J. S.<br />
Ross 2 , A. Umantsev 2 and S. L. Chao 2 . 1 Department <strong>of</strong><br />
Chemistry, North Carolina State University, Raleigh,<br />
NC and 2 Department <strong>of</strong> Natural Sciences, Fayetteville<br />
State University, Fayetteville, NC. Sponsor: J. Casida.<br />
#977 NEUROPATHOLOGICAL FINDINGS IN<br />
DEVELOPMENTAL NEUROTOXICITY<br />
TESTING: COMPARISON OF QUALITATIVE<br />
AND QUANTITATIVE EVALUATIONS. K.<br />
Raffaele 1 , W. Sette 2 , J. Doherty 1 , S. Makris 1 and K.<br />
Cr<strong>of</strong>ton 3 . 1 OPP, U.S. EPA, Washington, DC, 2 OSA, U.S.<br />
EPA, Washington, DC and 3 NHEERL, ORD, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#978 A SIMPLE METHOD TO ESTIMATE RAT PUP<br />
EXPOSURE IN DIETARY DEVELOPMENTAL<br />
NEUROTOXICITY STUDIES. M. L. Weiner 1 , J. D.<br />
McCarty 1 , A. Chen 1 , M. Nemec 2 , G. Schaefer 2 and J.<br />
Buelke-Sam 3 . 1 <strong>Toxicology</strong>, FMC Corporation,<br />
Princeton, NJ, 2 WIL Research Laboratories, Ashland,<br />
OH and 3 <strong>Toxicology</strong> Services, Greenfield, IN.<br />
#979 THALIDOMIDE-INDUCED OXIDATIVE STRESS<br />
IN RAT DORSAL ROOT GANGLIA (DRG) CELL<br />
CULTURES. R. Roman Gomez 1 , C. A. Flynn 1 , T. L.<br />
Builee 1 , P. A. Paximadis 1 , J. M. Hansen 2 , M. A.<br />
Philbert 1 and C. Harris 1 . 1 Environmental Health<br />
Sciences, University <strong>of</strong> Michigan, Ann Arbor, MI and<br />
2 Biochemistry, Emory University, Atlanta, GA.<br />
#980 EFFECTS OF DEVELOPMENTAL<br />
HYPOTHYROIDISM INDUCED BY PTU ON<br />
BRAIN FUNCTION IN RATS. R. Tsuji, K.<br />
Kobayashi, T. Yoshioka, M. Sasaki, M. kushida, S.<br />
Yabushita, T. Mino and T. Seki. Sumitomo Chemical<br />
Co., Ltd., Environmental Health Science Laboratory,<br />
Osaka, Japan. Sponsor: T. Yamada.<br />
#981 EFFECT OF HYPOTHYROIDISM INDUCED BY<br />
PERINATAL EXPOSURE TO PTU ON<br />
CEREBELLAR GENE EXPRESSION. K. kobayashi,<br />
R. Tsuji, T. Yoshioka, M. Kushida, T. Mino and T. Seki.<br />
Sumitomo Chemical Co., Ltd.,, Osaka, Japan. Sponsor:<br />
T. Yamada.<br />
#982 GABERGIC FUNCTION IS ALTERED<br />
FOLLOWING DEVELOPMENTAL<br />
HYPOTHYROIDISM: NEUROANATOMICAL<br />
AND NEUROPHYSIOLOGICAL EVIDENCE. M.<br />
E. Gilbert 1 , L. Sui 1,2 , S. Thomas 3 , S. Smoller 3 , J.<br />
Schon 3 and J. Goodman 3 . 1 Neurotoxicology, U.S. EPA,<br />
Research Triangle Park, NC, 2 NRC, Washington, DC<br />
and 3 CNRRR, Helen Hayes Hosp, W Haverstraw, NY.<br />
#983 VITAMIN E PROTECTS AGAINST THE<br />
BEHAVIORAL DEFICITS PRODUCED BY<br />
NEONATAL SODIUM VALPROATE EXPOSURE<br />
IN MICE. A. K. Halladay 1,3 , G. C. Wagner 2,3 , X.<br />
Ming 3 and K. R. Reuhl 1,3 . 1 Pharmacology &<br />
<strong>Toxicology</strong>, Rutgers University, Piscataway, NJ,<br />
2 Psychology, Rutgers University, Piscataway, NJ and<br />
3 Center for Childhood Neurotoxicology & Exposure<br />
Assessment, UMDNJ, New Brunswick, NJ.<br />
#984 CAMPTOTHECIN-INDUCED APOPTOSIS IN<br />
NEURAL STEM CELLS AND DIFFERENTIATED<br />
CULTURES THROUGH TWO DIFFERENT<br />
MECHANISMS. J. Li, M. L. Spletter and J. A.<br />
Johnson. University <strong>of</strong> Wisconsin at Madison, Madison,<br />
WI.<br />
#985 THE ROLE OF AMYLOID-β AND α-SECRETASE<br />
CLEAVED AMYLOID PRECURSOR PROTEIN<br />
ON NEUROGENESIS IN ADULT HUMAN<br />
NEOCORTICAL SLICE CULTURES. J. Kim 1 , T. D.<br />
Stein 2 , N. J. Anders 1 and J. A. Johnson 1,2,3 . 1 School <strong>of</strong><br />
Pharmacy, University <strong>of</strong> Wisconsin-Madison, Madison,<br />
WI, 2 Neuroscience Training <strong>Program</strong>, University <strong>of</strong><br />
Wisconsin-Madison, Madison, WI and 3 Waisman<br />
Center, University <strong>of</strong> Wisconsin-Madison, Madison, WI.<br />
#986 BISPHENOL-A, AN ENVIRONMENTAL<br />
CONTAMINANT THAT ACTS AS A THYROID<br />
HORMONE RECEPTOR ANTAGONIST IN<br />
VITRO, INCREASES SERUM THYROXINE AND<br />
ALTERS RC3/NEUROGRANIN EXPRESSION IN<br />
THE DEVELOPING RAT BRAIN. R. Bansal and C.<br />
Parris. Biology, University <strong>of</strong> Massachusetts, Amherst,<br />
MA. Sponsor: R. Zoeller.<br />
#987 EXPOSURE OF RHESUS MONKEYS TO<br />
COCAINE THROUGHOUT GESTATION<br />
RESULTS IN DECREASED SENSITIVITY TO<br />
COCAINE IN ADULTHOOD: EFFECTS OF<br />
COCAINE ON TIMING BEHAVIOR. M. G.<br />
Paule 1,3 , M. P. GIllam 1 , S. A. Graham 3 and J. J.<br />
Chelonis 2,3,1 . 1 Division <strong>of</strong> Neurotoxicology, National<br />
Center for Toxicological Research, Jefferson, AR,<br />
2 Graduate School, University <strong>of</strong> Arkansas at Little<br />
Rock, Little Rock, AR and 3 Pediatrics, Arkansas<br />
Children’s Hosptal, Little Rock, AR.<br />
#988 OBSERVATION OF CATECHOLAMINERGIC<br />
NEURONS IN THE FETAL RAT BRAIN<br />
EXPOSED TO THE GENOTOXIC COMPOUND,<br />
5-BROMO-2’-DEOXYURIDINE (BRDU). T.<br />
Ogawa 1 , M. Kuwagata 1,2 , K. T. Muneoka 1 and S.<br />
Shioda 1 . 1 Anatomy, Showa University School <strong>of</strong><br />
Medicine, Tokyo, Japan and 2 Hatano Research Institute,<br />
Kanagawa, Japan.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 123
44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
TUESDAY<br />
#989 HETEROGENEOUS SENSITIVITY OF THE<br />
EMBRYONIC NERVOUS SYSTEM TO THE<br />
GENOTOXIC AGENT BRDU IN MICE. M.<br />
Kuwagata 1,2 , T. Ogawa 2 , K. T. Muneoka 2 , H. Ono 1 and<br />
S. Shioda 2 . 1 <strong>Toxicology</strong>, Hatano Research Institute,<br />
Food and Drug Safety Center, Kanagawa, Japan and<br />
2 Anatomy, Showa University School <strong>of</strong> Mrdicine,<br />
Tokyo, Japan.<br />
Tuesday Morning, March 8<br />
9:45 AM to 10:45 AM<br />
Room 223<br />
INFORMATIONAL SESSION: EXPRESSION PROFILING WITH<br />
BEADARRAY TM TECHNOLOGY: IDENTIFICATION OF GENES<br />
INDUCED BY LOW LEVEL OXIDATIVE STRESS — PRESENTED BY<br />
ILLUMINA<br />
We examined variability in bead-based oligonucleotide microarrays by evaluation<br />
<strong>of</strong> dispersion characteristics among hybridization and biological replicate<br />
samples <strong>of</strong> lymphocyte RNA. Using a consecutive sampling and coincidence<br />
test, we have identified genes whose expression was significantly altered by low<br />
level exposure to oxidative stress.<br />
Tuesday Morning, March 8<br />
9:45 AM to 10:45 AM<br />
Room 215<br />
INFORMATIONAL SESSION: TOXICITY TESTING: WHAT BONE<br />
MARROW CAN TELL US — PRESENTED BY STEMCELL<br />
TECHNOLOGIES, INC.<br />
Over the past three decades, a spectrum <strong>of</strong> standardized assays has been developed<br />
to characterize and measure bone marrow function and assess the multiple<br />
cell lineages it contains. In humans, bone marrow is one <strong>of</strong> the five major organ<br />
systems most sensitive to chronic low-dose chemical toxicants, making it an<br />
important target to assess in toxicity screening. This session will illustrate the<br />
rationale for targeting bone marrow for drug toxicity screening, assays that are<br />
employed and importance <strong>of</strong> using primary human cells in functional cell-based<br />
assays.<br />
Tuesday Morning, March 8<br />
11:00 AM to 12:00 NOON<br />
Room 223<br />
Tuesday Morning, March 8<br />
11:00 AM to 12:00 NOON<br />
Room 215<br />
INFORMATIONAL SESSION: SEARCHING THE NTP DATABASES —<br />
PRESENTED BY NIEHS<br />
The National <strong>Toxicology</strong> <strong>Program</strong> (NTP) conducts studies on potentially toxic<br />
agents to determine their impact on human health. Enhancing public access to<br />
these data, this workshop provides information about what is available within<br />
the NTP databases, using real examples to demonstrate the search process.<br />
Tuesday Afternoon, March 8<br />
12:00 NOON to 1:15 PM<br />
La Louisiane Ballroom A<br />
Tuesday Afternoon<br />
IN VITRO TOXICOLOGY LECTURE: USING IN VITRO<br />
TOXICOLOGY TO PROTECT HUMAN HEALTH AND ADVANCE<br />
ANIMAL WELFARE<br />
Lecturer: William S. Stokes, DVM, NIEHS, Research Triangle Park, NC.<br />
Sponsored by:<br />
The Colgate-Palmolive Company<br />
This lecture will discuss the application <strong>of</strong> in vitro toxicology to regulatory<br />
safety assessment and provide examples <strong>of</strong> how recently adopted in vitro test<br />
methods have benefited animal welfare by refining and reducing animal use<br />
while providing for the protection <strong>of</strong> human heath. The process by which new<br />
technological methods evolve from development to regulatory acceptance will<br />
be discussed, including the validation process necessary to determine their<br />
usefulness and limitations for defined specific purpose. Dr. Stokes will also<br />
discuss expected opportunities for an expanded role for in vitro toxicology in an<br />
integrated approach to safety assessment.<br />
Students register for this event on the Annual Meeting Registration form; a $5<br />
deposit per ticket is required and will be exchanged for the ticket at the<br />
luncheon. Seating is limited.<br />
INFORMATIONAL SESSION: DESIGNING BETTER PRECLINICAL<br />
STUDIES USING GENE EXPRESSION ANALYSIS — PRESENTED BY<br />
GENE LOGIC<br />
Understanding the expression pattern <strong>of</strong> a target protein in various tissues can<br />
help you plan your small molecule and biologics safety studies with more precision<br />
by suggesting additional target tissues and potential areas for concern. In<br />
this presentation, you will hear case studies on how scientists can use Gene<br />
Logic’s web-based ASCENTA System to design better preclinical studies.<br />
124<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Afternoon, March 8<br />
12:00 NOON to 1:00 PM<br />
La Louisiane Ballroom B<br />
SOT/EUROTOX DEBATE<br />
Motion: Nanoparticles are a Major Threat to Human Health<br />
Sponsored by:<br />
SOT (<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>)<br />
EUROTOX (European Societies <strong>of</strong> <strong>Toxicology</strong>)<br />
Debaters:<br />
(Pro) SOT: Joseph V. Rodricks, Ph.D., DABT, The ENVIRON<br />
Institute for Health Risk Sciences, Arlington, VA<br />
(Con) EUROTOX: Anthony Seaton, Pr<strong>of</strong> Emeritus, University <strong>of</strong><br />
Aberdeen, Scotland.<br />
Nanoparticles represent an explosively expanding technology for selective drug<br />
delivery. The number <strong>of</strong> potential applications is limitless; However the highly<br />
penetrant properties raises serious concern regarding wide-spread, uncontrolled<br />
distribution and possible persistence <strong>of</strong> these particles within living systems.<br />
The discussants will produce strong and persuasive arguments both in support<br />
and to refute adverse human health concerns <strong>of</strong> this rapidly emerging technology.<br />
Tuesday Afternoon, March 8<br />
12:15 PM to 1:15 PM<br />
Room 223<br />
INFORMATIONAL SESSION: RAPID GENERATION OF<br />
PREDICTIVE TOXICOGENOMIC ANALYSIS — PRESENTED BY<br />
GENE LOGIC<br />
Learn how to facilitate drug candidate selection by characterizing a compound's<br />
toxicity pr<strong>of</strong>ile using an easy, intuitive toxicogenomic-based s<strong>of</strong>tware application.<br />
Several case studies will be discussed that demonstrate how these rapidly<br />
generated results can be combined with other data to help make better inform<br />
compound decisions.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 2:30 PM<br />
Room 215<br />
INFORMATIONAL SESSION: LEVERAGING A MULTI-<br />
DIMENSIONAL CARDIOVASCULAR ASSESSMENT DURING LEAD<br />
OPTIMIZATION — PRESENTED BY CORDYNAMICS<br />
CorDynamics is a contract research organization focused on examining the<br />
cardiac effects <strong>of</strong> emerging drug candidates. Our models allow us to optimize<br />
these lead candidates early in the drug development process. Focusing on this<br />
critical and dynamic phase improves the attrition rates <strong>of</strong> compounds selected<br />
for further testing, thereby reducing the overall costs and timelines associated<br />
with your projects.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 3:30 PM<br />
Room RO2<br />
FORUM ON GRANTSMANSHIP AND SOURCES FOR RESEARCH<br />
SUPPORT<br />
Chairperson(s): Mitzi Nagarkatti, Virginia Commonwealth University,<br />
Richmond, VA and Rosita R. Proteau, Oregon State University, Corvallis, OR.<br />
Sponsored by:<br />
Career Resource and Development Committee (formerly the Placement<br />
Committee)<br />
Education Committee<br />
The Grantsmanship Forum will provide an overview <strong>of</strong> a variety <strong>of</strong> research<br />
funding sources and tips for successful applications for scientists at all stages <strong>of</strong><br />
their research careers.<br />
The first two talks will address NIH funding, including the reorganization <strong>of</strong> the<br />
review process by the Center for Scientific Research (CSR), which reviews the<br />
majority <strong>of</strong> applications to NIH. For the toxicology community, this restructuring<br />
has meant the elimination <strong>of</strong> two <strong>of</strong> the study sections in which many<br />
toxicology grant applications were reviewed. A third study section, used for<br />
neurotoxicology applications, was replaced. There has been confusion among<br />
applicants about the appropriate study section for their applications, as well as<br />
concern about toxicology applications getting proper reviews. The first speaker<br />
will provide a brief overview <strong>of</strong> the restructuring process, some results<br />
regarding toxicology applications from the first several review cycles, and some<br />
thoughts for applicants on how to work within the new system and hopefully be<br />
more successful.<br />
The second presentation will provide an overview <strong>of</strong> some <strong>of</strong> the specialized<br />
NIH grant mechanisms available to support research, training and career development.<br />
Included will be information on Career Development Awards (K series<br />
grants), Fellowships (F series grants), Training (T series grants), and research<br />
grants designed for specialized goals (R series grants).<br />
The EPA is another significant funding source for toxicologists. The third<br />
speaker will discuss EPA’S extramural grants and fellowship program with<br />
particular emphasis on Science to Achieve Results (STAR) <strong>Program</strong>. The EPA<br />
issues requests for applications in targeted areas that complement EPA’s intramural<br />
research programs. First, applications undergo a scientific review by an<br />
external peer panel, and then an internal programmatic review. These grants lead<br />
to interactions between extramural and intramural scientists. In addition, EPA<br />
supports graduate students in environmental science and engineering through<br />
the STAR program.<br />
Significant opportunities for research funding beyond NIH and EPA are also<br />
available. An experienced SOT investigator will provide perspectives on finding<br />
these sources. Learn ways to identify these alternative funding sources and their<br />
missions. Each funding source has a set <strong>of</strong> goals that need careful consideration<br />
as you apply for dollars to support your research effort.<br />
Time will be available for specific questions to these speakers.<br />
1:30 PM Introduction, Mitzi Nagarkatti, Virginia<br />
Commonwealth University, Richmond, VA.<br />
1:35 PM Reorganization <strong>of</strong> NIH Study Sections, Patrick<br />
Mastin, NIEHS, Research Triangle Park, NC.<br />
2:10 PM Non-Conventional Sources <strong>of</strong> NIH Funding, Carol<br />
Shreffler, NIEHS, Research Triangle Park, NC.<br />
2:45 PM Funding from Environmental Protection Agency,<br />
Elaine Z. Francis, U.S. EPA, Washington, DC.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 125
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
3:20 PM Funding Alternatives to NIH: Being Creative,<br />
Jean F. Regal, University <strong>of</strong> Minnesota Medical<br />
School, Duluth, MN.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room RO1<br />
SYMPOSIUM SESSION: THE AHR IN CELL GROWTH AND DEATH<br />
Chairperson(s): David Sherr, Boston University School <strong>of</strong> Public Health,<br />
Boston, MA and Prakash Nagarkatti, Virginia Commonwealth University,<br />
Richmond, VA.<br />
Endorsed by:<br />
Immunotoxicology SS<br />
Since its first description as a dioxin-binding protein in the 1980s, the aryl<br />
hydrocarbon receptor (AhR) has been studied primarily for its control <strong>of</strong><br />
biologic responses to environmental agonists. However, in the last few years it<br />
has become apparent that the AhR, which clearly did not evolve to recognize<br />
environmental pollutants, likely plays an important physiologic function.<br />
Indeed, the ability <strong>of</strong> the AhR to directly regulate important cellular genes and<br />
factors such as Bax, the estrogen receptor, Rb, and NF-kB hints at a critical role<br />
for the AhR in cell growth and death. The presence <strong>of</strong> constitutively active AhR<br />
in cells that exhibit aberrant growth and apoptosis regulation, i.e. neoplastic<br />
cells, further supports this hypothesis. In this symposium we will present several<br />
examples <strong>of</strong> AhR-mediated control <strong>of</strong> cell growth and death and will begin to<br />
detail the molecular mechanisms through which this control is manifest. In<br />
some studies presented herein, AhR function is revealed with exogenous<br />
agonists such as TCDD or PAH. In other cases, constitutive AhR function is<br />
demonstrated by modulation <strong>of</strong> AhR expression and activity in the absence <strong>of</strong><br />
exogenous ligands. In all cases, the roles that the AhR may play in normal<br />
cellular physiology and the consequences <strong>of</strong> disrupting these functions with<br />
environmental agonists are discussed.<br />
#990 1:30 THE AHR IN CELL GROWTH AND DEATH. D. H.<br />
Sherr 1 and P. Nagarkatti 2 . 1 Environmental Health,<br />
Boston University School <strong>of</strong> Public Health, Boston, MA<br />
and 2 Department <strong>of</strong> Pharmacology and <strong>Toxicology</strong>,<br />
Virginia Commonwealth Unviersity, Richmond, VA.<br />
#991 1:40 LIGATION OF AHR LEADS TO UP-<br />
REGULATION OF APOPTOTIC GENES<br />
THROUGH DRE-DEPENDENT AND -<br />
INDEPENDENT PATHWAYS INVOLVING NF-KB<br />
AND CONSEQUENT INDUCTION OF<br />
APOPTOSIS IN THYMOCYTES. P. S. Nagarkatti.<br />
Pharmacology and <strong>Toxicology</strong>, Medical College <strong>of</strong><br />
Virginia Campus, Virginia Commonwealth University,<br />
Richmond, VA.<br />
#992 2:10 AHR CONTROL OF B LYMPHOCYTE DEATH<br />
AND GROWTH. S. H. David, H. Ryu, J. K. Emberley,<br />
L. L. Allan and J. J. Schlezinger. Environmental Health,<br />
Boston University School <strong>of</strong> Public Health, Boston,<br />
MA.<br />
#993 2:40 REGULATION OF MAMMARY TUMOR<br />
GROWTH THROUGH THE ARYL<br />
HYDROCARBON RECEPTOR. S. H. Safe.<br />
Veterinary Physiology, Texas A & M University,<br />
College Station, TX.<br />
#994 3:10 CURRENT INSIGHTS INTO AHR-MEDIATED<br />
LIVER CELL CYCLE CONTROL. C. J. Elferink.<br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Texas<br />
Medical Branch, Galveston, TX. Sponsor: D. Sherr.<br />
#995 3:40 AHR CONTROL OF APOPTOSIS INDUCED BY<br />
AGENTS CAUSING LYSOSOMAL DAMAGE. J. J.<br />
Reiners. Institute <strong>of</strong> Environmental Health Sciences,<br />
Wayne State University, Detroit, MI. Sponsor: D.<br />
Sherr.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room RO4<br />
SYMPOSIUM SESSION: ORGANOPHOSPATES & CARBMATES:<br />
CHOLINERGIC VS. NONCHOLINERGIC MECHANISMS<br />
Chairperson(s): Ramesh Gupta, Murray State University, Hopkinsville, KY<br />
and Carey N. Pope, Oklahoma State University, Stillwater, OK.<br />
Endorsed by:<br />
Comparative and Veterinary SS<br />
Neurotoxicology SS*<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Organophosphates (OPs) and carbamates (CMs) are commonly used as pesticides<br />
in agriculture, industry, and around the home/garden. Some OPs have also<br />
been used in chemical warfare and terrorism, while some CMs have been used<br />
to treat diseases such as myasthenia gravis and dementia. Interestingly, the CM<br />
pyridostigmine is used prophylactically to protect soldiers from possible OP<br />
nerve agent exposure. Many compounds <strong>of</strong> both classes are extremely toxic and<br />
lack selectivity, thus their inadvertent/accidental use continues to pose a threat<br />
to human and animal health, aquatic systems and wildlife. While these<br />
compounds have a wide variety <strong>of</strong> toxic effects, neurotoxicity elicited by inhibition<br />
<strong>of</strong> acetylcholinesterase (AChE) is generally <strong>of</strong> primary concern. In recent<br />
years, a variety <strong>of</strong> novel mechanisms for OPs and CMs have been proposed<br />
which may modulate cholinergic neurotoxicity or lead to non-cholinergic<br />
effects. Molecular studies <strong>of</strong> AChE and its interaction with inhibitors has<br />
allowed a more thorough characterization <strong>of</strong> the structure, function, and regulation<br />
<strong>of</strong> this enzyme. In vitro studies indicate that NGF-differentiated SY5Y cells<br />
may distinguish between OPs that produce OPIDN and those that do not, and<br />
may therefore be a suitable mechanistic model for exploring the effects <strong>of</strong><br />
different classes <strong>of</strong> OPs. Evidence suggests that while cholinergic mechanisms<br />
play a critical role in the initial stage <strong>of</strong> cholinergic toxicity, neuronal<br />
damage/death may occur through non-cholinergic mechanisms including oxidative<br />
stress. The Food Quality Protection Act <strong>of</strong> 1996 requires EPA to consider<br />
the cumulative risk to pesticides with a common mechanism <strong>of</strong> action. In the<br />
case <strong>of</strong> OPs and CMs, this common mechanism is initiated by inhibition <strong>of</strong><br />
AChE (via phosphorylation or carbamylation, respectively). However,<br />
noncholinergic mechanisms are not currently considered in risk assessment.<br />
This symposium will review the latest developments in understanding <strong>of</strong> molecular<br />
mechanisms (cholinergic and non-cholinergic) for these toxicants, as well<br />
as discuss current strategies <strong>of</strong> cumulative risk assessment for pesticides acting<br />
through a common mechanism.<br />
#996 1:30 ORGANOPHOSPHATES & CARBAMATES:<br />
CHOLINERGIC & NONCHOLINERGIC<br />
MECHANISMS. R. C. Gupta. <strong>Toxicology</strong>, Murray<br />
State University, Hopkinsville, KY.<br />
#997 1:40 CONTEMPORARY PROTEOMICS IN<br />
ACETYLCHOLINESTERASE AND RELATED α,<br />
β HYDROLASE-FOLD PROTEINS AS TARGETS<br />
OF TOXICOLOGICAL MANIFESTATIONS AND<br />
GENETIC DISORDERS. P. Taylor, Z. Radic, L.<br />
Jennings and S. Camp. Pharmacology, University <strong>of</strong><br />
California, San Diego, La Jolla, CA. Sponsor: R.<br />
Gupta.<br />
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<strong>Program</strong> Description<br />
#998 2:10 ORGANOPHOSPHORUS AND CARBAMATE<br />
CHOLINESTERASE INHIBITORS: USES AND<br />
MISUSES OF A COMMON MECHANISM. C. N.<br />
Pope. Physiological Sciences, Oklahoma State<br />
University, Stillwater, OK.<br />
#999 2:40 IN VITRO MODELS FOR TESTING<br />
NEUROTOXICITY OF ORGANOPHOSPHORUS<br />
COMPOUNDS AND PROTECTIVE EFFECTS OF<br />
OP HYDROLASE. E. Tiffany-Castiglioni. Veterinary<br />
Anatomy and Public Health, Texas A&M University,<br />
College Station, TX.<br />
#1000 3:10 OXIDATIVE STRESS INVOLVEMENT IN<br />
NEUROTOXICITY OF ORGANOPHOSPHATES<br />
AND CARBAMATES. R. C. Gupta 1 , S. Milatovic 2 , T.<br />
J. Montine 2 , W. D. Dettbarn 3 and D. Milatovic 2 .<br />
1 <strong>Toxicology</strong>, Murray State University, Hopkinsville,<br />
KY, 2 University <strong>of</strong> Washington, Seattle, WA and<br />
3 Vanderbilt University, Nashville, TN.<br />
#1001 3:40 EPA PERSPECTIVE: SCIENTIFIC<br />
APPROACHES FOR ASSESSING THE<br />
CUMULATIVE RISK OF<br />
ORGANOPHOSPHORUS AND N-METHYL<br />
CARBAMATE CHOLINESTERASE INHIBITING<br />
PESTICIDES. A. Lowit. Office <strong>of</strong> Pesticide <strong>Program</strong>s,<br />
U.S. EPA, Washington, DC. Sponsor: R. Gupta.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
La Louisiane Ballroom B<br />
SYMPOSIUM SESSION: PROTEOMICS AND ANTIBODY<br />
MICROARRAYS: APPLICATIONS IN TOXICOLOGY<br />
Chairperson(s): Richard Zangar, Pacific Northwest Laboratories, Richland,<br />
WA and Alex Merrick, National Institute for Envirornmental Health Sciences,<br />
Research Triangle Park, NC.<br />
#1003 1:35 ANALYSIS OF MARKERS OF CANCER AND<br />
XENOBIOTIC EXPOSURE USING ANTIBODY<br />
MICROARRAYS. R. C. Zangar 1 , S. M. Varnum 1 , D.<br />
S. Daly 1 , A. M. White 1 , C. Y. Covington 2 , S. Wiley 1 , B.<br />
D. Thrall 1 and R. D. Stenner 1 . 1 Pacific Northwest<br />
National Laboratory, Richland, WA and 2 University <strong>of</strong><br />
California School <strong>of</strong> Nursing, Los Angeles, CA.<br />
#1004 2:10 FINDING NEW SIGNAL TRANSDUCTION<br />
PARADIGMS USING PROTEIN-DOMAIN<br />
MICROARRAY. M. T. Bedford, A. Espejo and J.<br />
Daniel. MD Anderson Cancer Center, Bastrop, TX.<br />
Sponsor: R. Zanger.<br />
#1005 2:45 PROTEOMIC ANALYSIS OF SERUM PROTEINS<br />
DURING ACUTE ACETAMINOPHEN TOXICITY<br />
IN RATS REVEALS ACUTE PHASE AND<br />
ANTIOXIDANT RESPONSE. B. A. Merrick 1 , K. B.<br />
Tomer 1 , M. E. Bruno 1 , J. H. Madenspacher 1 , B. A.<br />
Wetmore 1 , R. Pieper 2 , C. L. Gatlin 2 , M. M. Andrew 2 , A.<br />
J. Makusky 2 , M. Zhao 2 , J. Zhou 2 , J. Taylor 2 , S. Steiner 2<br />
and R. W. Tennant 1 . 1 NCT, NIEHS, Research Triangle<br />
Park, NC and 2 Proteomics, LSBC, Germantown, MD.<br />
#1006 3:20 IDENTIFYING PROTEIN MODIFICATIONS<br />
RESULTING FROM OXIDATIVE STRESS USING<br />
LC/ESI/MS. I. A. Blair, S. Lee and T. Oe.<br />
Pharmacology, University <strong>of</strong> Pennsylvania, Philadephia,<br />
PA. Sponsor: R. Zanger.<br />
#1007 3:55 COMPARATIVE PROTEOMIC ANALYSIS OF<br />
CONTROL AND TUMOR-BEARING MOUSE<br />
PLASMA BY GEL-LC-MS/MS. S. R. Tannenbaum, V.<br />
B. Bhat, M. Choi and J. S. Wishnok. Biological<br />
Engineering Division, MIT, Cambridge, MA.<br />
TUESDAY<br />
Endorsed by:<br />
Mechanisms SS*<br />
Molecular Biology SS<br />
Student Advisory Committee<br />
It is now possible to sequence a whole genome and predict the complete<br />
proteome <strong>of</strong> an organism. This information, when used in combination with<br />
sophisticated techniques for protein analysis such as tandem mass spectrometry<br />
(MS), allows for the rapid analysis <strong>of</strong> hundreds or thousands <strong>of</strong> proteins in a<br />
single biological sample. These proteomic technologies <strong>of</strong>fer the ability to<br />
rapidly determine which <strong>of</strong> the identified proteins are altered in response to<br />
toxicity, xenobiotic exposure or various disease states. One specialized application<br />
<strong>of</strong> proteomics technology is the analysis <strong>of</strong> protein modifications. Since<br />
many <strong>of</strong> the toxic effects <strong>of</strong> xenobiotic exposure and oxidative stress are associated<br />
with covalent protein modifications, this area <strong>of</strong> research is expected to<br />
result in significant advances in our understanding <strong>of</strong> the molecular basis for<br />
toxicity. Another rapidly developing technology is protein arrays, which can be<br />
used for broad comparisons <strong>of</strong> protein-protein interactions or quantitative<br />
analyses. In comparison to MS-based analyses, protein microarrays generally<br />
have greater throughput but are limited to a select group <strong>of</strong> proteins. Overall,<br />
these developing technologies are expected to provide a broader insight into the<br />
mechanisms <strong>of</strong> toxicity and identify new markers <strong>of</strong> disease and toxicity.<br />
#1002 1:30 PROTEOMICS AND ANTIBODY<br />
MICROARRAYS: APPLICATIONS IN<br />
TOXICOLOGY. R. C. Zangar. Pacific Northwest<br />
National Laboratory, Richland, WA.<br />
up-to-date information at www.toxicology.org 127
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<strong>Program</strong> Description<br />
TUESDAY<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room RO8<br />
SYMPOSIUM SESSION: UPDATE ON MECHANISMS FOR<br />
ENVIRONMENTAL TOBACCO SMOKE-INDUCED HEALTH<br />
EFFECTS<br />
Chairperson(s): Chris A. Pritsos, University <strong>of</strong> Nevada, Reno, NV and Kevin<br />
E. Pinkerton, University <strong>of</strong> California, Davis, Davis, CA.<br />
Endorsed by:<br />
Occupational and Public Health SS<br />
Risk Assessment SS<br />
Epidemiological evidence has demonstrated an association between exposure to<br />
environmental tobacco smoke (ETS) and disease. Diseases associated with ETS<br />
exposure include a variety <strong>of</strong> cancers, cardiovascular disease, COPD, asthma<br />
and a number <strong>of</strong> perinatal manifestations, to name a few. While many <strong>of</strong> these<br />
exposure/disease associations are strong, the mechanism(s) by which ETS exposure<br />
influences the etiology <strong>of</strong> these diseases remains unclear. There are a great<br />
number <strong>of</strong> confounding factors which make ascribing any ETS-induced mechanism<br />
for disease difficult. Included amongst these factors is the immense<br />
complexity <strong>of</strong> the substituents which make up ETS. ETS is comprised <strong>of</strong> both a<br />
vapor phase and particulate phase with over 4000 chemicals identified to date.<br />
One must not only consider the effect <strong>of</strong> individual compounds but must also<br />
consider potential synergism between compounds. Another factor which needs<br />
to be considered is the fact that exposure to tobacco smoke compounds is<br />
substantially less than for smokers, due to dilution <strong>of</strong> the smoke. Chemical reactivity<br />
or “aging” <strong>of</strong> the ETS components can also modify their chemical nature.<br />
Also, an individual’s susceptibility to the harmful effects <strong>of</strong> ETS exposure can<br />
be greatly influenced by their genetic makeup. While quite complex, certain<br />
mechanistic themes are beginning to emerge as characteristic <strong>of</strong> ETS’s association<br />
with these diseases. The speakers will provide recent advances in our<br />
understanding <strong>of</strong> the mechanisms by which ETS can influence the etiology <strong>of</strong><br />
these diseases and provide a linkage between the epidemiological and biochemical/pathophysiological<br />
bases <strong>of</strong> disease. The symposium will have two<br />
presentations each dealing with: ETS and cardiovascular disease, ETS and<br />
cancer and ETS and respiratory diseases.<br />
#1008 1:30 UPDATE ON MECHANISMS FOR<br />
ENVIRONMENTAL TOBACCO SMOKE-<br />
INDUCED HEALTH EFFECTS. C. A. Pritsos 1 and<br />
K. E. Pinkerton 2 . 1 Nutrition, University <strong>of</strong> Nevada,<br />
Reno, NV and 2 Center for Health and the Environment,<br />
University <strong>of</strong> California, Davis, CA.<br />
#1009 1:35 IMPACT OF WORKPLACE ETS EXPOSURE ON<br />
RISK FACTORS FOR CORONARY HEART<br />
DISEASE. C. A. Pritsos 1 , G. R. Cutter 2 , S. St. Jeor 3 , J.<br />
A. Ashley 1 , S. Perumean-Chaney 2 , S. Clodfelter 1 , J. E.<br />
Woodrow 1 , A. C. Collier 1 , L. D. Bowen 1 , N. J. Martin 1<br />
and K. L. Pritsos 1 . 1 Nutrition, University <strong>of</strong> Nevada,<br />
Reno, NV, 2 Biostatistics, University <strong>of</strong> Alabama,<br />
Birmingham, Birmingham, AL and 3 Internal Medicine,<br />
University <strong>of</strong> Nevada, Reno, NV.<br />
#1010 2:00 IMPACT OF PRENATAL CARDIOVASCULAR<br />
DISEASE RISK FACTOR EXPOSURE ON<br />
MITOCHONDRIAL DAMAGE AND ADULT<br />
HEART DISEASE DEVELOPMENT. S. W.<br />
Ballinger 1 , Z. Yang 1 and A. Penn 2 . 1 Pathology,<br />
University Alabama at Birmingham, Birmingham, AL<br />
and 2 Veterinary Medicine, Louisiana State University,<br />
Baton Rouge, LA.<br />
#1011 2:30 IMMUNOLOGIC DETECTION OF<br />
CARCINOGEN-DNA AND PROTEIN ADDUCTS.<br />
R. M. Santella. Environmental Health Sciences,<br />
Columbia University, New York.<br />
#1012 3:00 ETS IMPACT ON ALLERGIC AIRWAYS<br />
RESPONSES TO ANTIGEN. A. penn 1 , D. Paulsen 2<br />
and D. Horohov 3 . 1 CBS, LSU Vet.Med., Baton Rouge,<br />
LA, 2 PBS, LSU Vet.Med., Baton Rouge, LA and 3 Vet.<br />
Sciences., University <strong>of</strong> KY, Lexington, KY.<br />
#1013 3:30 GESTATIONAL STAGE-SPECIFIC ETS-<br />
INDUCED OXIDATIVE DNA DAMAGE. L. M.<br />
Anderson 1 , A. Maciag 1 , I. Espiritu 2 , A. Bialkowska 1 , K.<br />
Kasprzak 1 and H. Witschi 2 . 1 Lab. Comparative<br />
Carcinogenesis, National Cancer Inst., Frederick, MD<br />
and 2 Center for Health and the Environment, University<br />
<strong>of</strong> California, Davis, CA.<br />
#1014 4:00 EFFECTS OF ENVIRONMENTAL TOBACCO<br />
SMOKE ON CYTOKINES AND<br />
NEUROTROPHINS IN THE NEONATAL LUNG.<br />
K. E. Pinkerton, J. P. Joad and M. Yu. Center for Health<br />
and the Environment, University <strong>of</strong> California, Davis,<br />
CA.<br />
Abstract 1015 is located on page 150.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room 220<br />
WORKSHOP SESSION: CURRENT AND FUTURE SCIENCE-BASED<br />
APPROACHES TO DRUG SAFETY EVALUATION: AN ASSESSMENT<br />
OF POTENTIAL CANCER RISK<br />
Chairperson(s): Martha M. Moore, U.S. FDA, Jefferson, AR and David<br />
Jacobson-Kram, U.S. FDA, Rockville, MD.<br />
Endorsed by:<br />
Carcinogenesis SS*<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Currently the preclinical safety evaluation <strong>of</strong> pharmaceuticals for potential<br />
cancer risk includes the application <strong>of</strong> genetic toxicology assays and the rodent<br />
cancer bioassay. While data from rodent carcinogenicity studies are generally<br />
available prior to marketing approval, data from short-term studies is used to<br />
assess cancer risk during the drug development phases. Although this has generally<br />
been a successful approach there is wide discussion as to the appropriate<br />
role <strong>of</strong> the genetic toxicology assays and the possibility that other assays such as<br />
the Syrian hamster embryo (SHE) test and the shorter term transgenic cancer<br />
bioassays (Trp53 and rasH2) might be useful. The emerging “omics” technologies<br />
provide for possible new and improved approaches to understanding<br />
whether new drugs might cause an increased cancer risk. In addition, both<br />
present and future technologies have the potential to be applied within the<br />
context <strong>of</strong> the clinical trials. This session will provide a forum to discuss these<br />
issues. The first speaker will provide an overview <strong>of</strong> the current approaches and<br />
issues relevant to preclinical drug safety assessment. Additional speakers will<br />
discuss the current thinking on the use <strong>of</strong> genetic toxicology assays, the SHE<br />
assay and the transgenic cancer bioassays. The last two speakers will consider<br />
both the present and potential future applications <strong>of</strong> “omic” technologies and<br />
our ability to utilize individuals in clinical trials to provide a better assessment<br />
<strong>of</strong> the potential human cancer risk from pharmaceutical drugs.<br />
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<strong>Program</strong> Description<br />
#1025 1:30 CURRENT AND FUTURE SCIENCE-BASED<br />
APPROACHES TO DRUG SAFETY<br />
EVALUATION: AN ASSESSMENT OF<br />
POTENTIAL CANCER RISK. M. Moore. DGRT,<br />
NCTR, Jefferson, AR.<br />
#1026 1:35 OVERVIEW OF THE CANCER SAFETY<br />
ASSESSMENT IN CDER/FDA. A. Jacobs. U.S. FDA,<br />
Rockville, MD.<br />
#1027 2:10 THE ROLE OF GENETIC TOXICOLOGY<br />
ASSAYS IN A WEIGHT-OF-WVIDENCE CANCER<br />
ASSESSMENT FOR NEW PHARMACEUTICALS.<br />
D. Jacobson-Kram 1 . 1 FDA, Rockville, MD and 2 Office<br />
<strong>of</strong> New Drugs, Center for Drug Evaluation and<br />
Research, U.S. FDA, Rockville, MD.<br />
#1028 2:45 TRANSGENIC CANCER BIOASSAYS: A USEFUL<br />
ADDITION TO CANCER SAFETY ASSESSMENT<br />
OF NEW PHARMACEUTICALS? R. D. Storer.<br />
Safety Assessment, Merck Research Laboratories, West<br />
Point, PA.<br />
#1029 3:20 INTEGRATION OF OMIC DATA INTO CANCER<br />
RISK ASSESSMENT. Y. Dragan. Hepatic <strong>Toxicology</strong>,<br />
NCTR, Jefferson, AR.<br />
#1030 3:55 CANCER BIOMARKERS: CAN THEIR<br />
APPLICATION IN CLINICAL TRIALS IMPROVE<br />
THE SAFETY ASSESSMENT OF NEW<br />
PHARMACEUTICALS? R. J. Albertini. Genetic<br />
<strong>Toxicology</strong> Lab., University <strong>of</strong> Vermont, Burlington,<br />
VT. Sponsor: M. Moore.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room RO3<br />
WORKSHOP SESSION: MOLECULAR PATHWAYS TO TOXICANT-<br />
INDUCED OSTEOPOROSIS<br />
Chairperson(s): Maryka Bhattacharyya, Argonne National Laboratory,<br />
Argonne, IL and Edward Puzas, University <strong>of</strong> Rochester School <strong>of</strong> Medicine,<br />
Rochester, NY.<br />
Endorsed by:<br />
Mechanisms SS<br />
Metals SS*<br />
Student Advisory Committee<br />
Women in <strong>Toxicology</strong> SS<br />
Osteoporosis is a disease characterized by low bone mass and structural deterioration<br />
<strong>of</strong> bone tissue, leading to bone fragility and an increased susceptibility<br />
to fractures <strong>of</strong> the hip, spine, and wrist. This disease is responsible for more than<br />
1.5 million fractures annually; 44 million Americans have low bone mass such<br />
that they either have osteoporosis or are at significant risk <strong>of</strong> developing the<br />
disease. Of the 10 million who actually have osteoporosis, 80 percent are<br />
women. Men suffer one-third <strong>of</strong> all hip fractures that occur, and approximately<br />
one-third <strong>of</strong> these men will not survive more than one year after the fracture.<br />
Our population is increasing in the fraction <strong>of</strong> elderly persons faster than at any<br />
other time in human history. Understanding ways in which toxicants contribute<br />
to the development <strong>of</strong> osteoporosis is an important undertaking. In this workshop,<br />
we will provide 1) basic information on pathways <strong>of</strong> bone formation and<br />
bone resorption and their role in the development <strong>of</strong> osteoporosis, 2) new<br />
insights into how the important metals, lead and cadmium, affect bone cell pathways<br />
and contribute to metabolic bone disease, 3) the role that alcohol<br />
consumption may play in the development <strong>of</strong> osteoporosis, and 4) discussion by<br />
workshop participants <strong>of</strong> the results presented with respect to their application<br />
and relevance to human health.<br />
#1031 1:30 MOLECULAR PATHWAYS TO TOXICANT-<br />
INDUCED OSTEOPOROSIS. M. H. Bhattacharyya 1 ,<br />
E. Puzas 2 , J. B. Lian 3 , D. J. Novack 4 and M. J. Ronis 5 .<br />
1 Biosciences Division, Argonne National Laboratory,<br />
Argonne, IL, 2 University <strong>of</strong> Rochester School <strong>of</strong><br />
Medicine, Rochester, NY, 3 University <strong>of</strong> Massachusetts<br />
Medical School, Worcester, MA, 4 Washington<br />
University School <strong>of</strong> Medicine, St. Louis, MO and<br />
5 University <strong>of</strong> Arkansas Medical Sciences, Little Rock,<br />
AR.<br />
#1032 1:35 MOLECULAR PATHWAYS REGULATING<br />
OSTEOBLAST GROWTH AND<br />
DIFFERENTIATION. J. B. Lian and G. S. Stein.<br />
Department <strong>of</strong> Cell Biology and Cancer Center,<br />
University <strong>of</strong> Massachusetts Medical School, Worcester,<br />
MA. Sponsor: M. Bhattacharyya.<br />
#1033 2:05 MOLECULAR PATHWAYS REGULATING<br />
OSTEOCLAST DIFFERENTIATION AND<br />
FUNCTION. D. Novack. Medicine/Bone and Mineral,<br />
Washington University School <strong>of</strong> Medicine, St. Louis,<br />
MO. Sponsor: M. Bhattacharyya.<br />
#1034 2:35 LEAD-INDUCED OSTEOPOROSIS. J. E. Puzas.<br />
Department <strong>of</strong> Orthopaedics, University <strong>of</strong> Rochester<br />
School <strong>of</strong> Medicine, Rochester, NY.<br />
#1035 3:05 FROM ITAI-ITAI TO OSTEOCLASTS:<br />
PATHWAYS TO CADMIUM-INDUCED BONE<br />
LOSS. M. H. Bhattacharyya, A. Regunathan and D. A.<br />
Glesne. Biosciences Division, Argonne National<br />
Laboratory, Argonne, IL.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 129
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TUESDAY<br />
#1036 3:35 MECHANISMS OF ETHANOL-INDUCED BONE<br />
LOSS DIFFER WITH PHYSIOLOGICAL STATE.<br />
M. J. Ronis 1,2 , T. Badger 1,2 , C. Lumpkin 1 , J. Aronson 1 ,<br />
M. Hidestrand 1 , K. Shankar 1 and R. Haley 1,2 .<br />
1 University <strong>of</strong> Arkansas for Medical Sciences, Little<br />
Rock, AR and 2 Arkansas Children’s Nutrition Center,<br />
Little Rock, AR.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room 208<br />
PLATFORM SESSION: NANOPARTICLE TOXICITY<br />
Chairperson(s): Anna Shvedova, NIOSH, Morgantown, WV and Lung Chi<br />
Chen, NYU, Tuxedo, NY.<br />
#1037 1:30 TOXICITIES OF NANOMATERIALS. C. Quan 1 , S.<br />
Wilson 2 and L. Chen 1 . 1 School <strong>of</strong> Medicine, NYU,<br />
Tuxedo, NY and 2 New York University, New York.<br />
#1038 1:50 EXPOSURE TO ULTRAFINE ELEMENTAL<br />
CARBON PARTICLES (UCP) SIGNIFICANTLY<br />
INCREASE THROMBOGENESIS. V. M. Silva, N.<br />
Corson, A. Elder, R. Gelein and G. Oberdorster.<br />
Environmental Medicine, University <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#1039 2:10 NANOPARTICLE DEPOSITION EFFICIENCY IN<br />
HUMAN NASAL AIRWAY REPLICAS. B. A. Wong 1 ,<br />
J. T. Kelly 2 , J. S. Kimbell 1 and B. Asgharian 1 . 1 CIIT<br />
CHR, Research Triangle Park, NC and 2 University <strong>of</strong><br />
California, Davis, CA.<br />
#1040 2:30 ELECTRON MICROSCOPIC STUDY ON THE<br />
TRANSLOCATION OF ULTRAFINE CARBON<br />
BLACK PARTICLES AT THE AIRWAY-<br />
CAPILLARY BARRIER IN LUNG. A. Shimada, N.<br />
Kawamura, T. Kaewamatawong, M. Okajima, M.<br />
Sawada and T. Morita. Veterinary Pathology, Tottori<br />
University, Tottori-shi, Japan.<br />
#1041 2:50 PULMONARY TOXICITY OF CARBON<br />
NANOTUBES. E. Kisin 1 , A. R. Murray 3 , V. Johnson 2 ,<br />
O. Gorelik 4,5 , S. Arepalli 4,5 , V. Z. Gandelsman 4,5 , A. F.<br />
Hubbs 1 , R. R. Mercer 1,3 , P. Baron 6 , V. E. Kagan 7 , V.<br />
Castranova 1,3,7 and A. A. Shvedova 1,3 . 1 PPRB,<br />
HELD/NIOSH, Morgantown, WV, 2 TMBB,<br />
HELD/NIOSH, Morgantown, WV, 3 Physiology &<br />
Pharmacology, WVU, Morgantown, WV, 4 Lockheed<br />
Martin Corporation, Engineering Directorate, Material<br />
& Processes Branch, NASA-JSC, Houston, TX,<br />
5 Nanotube Team, GBTech, Inc., NASA-JSC, Houston,<br />
TX, 6 MRSA/DART, NIOSH, Cincinnati, OH and<br />
7 University <strong>of</strong> Pittsburgh, Pittsburgh, PA.<br />
#1042 3:10 RESPONSES OF LUNG PARENCHYMA TO<br />
CARBON NANOTUBES. R. R. Mercer 1,2 , J.<br />
Scabilloni 1,2 , K. Kisin 1 , O. Gorelik 3,4 , S. Arepalli 3,4 , A.<br />
R. Murray 2 , V. Castranova 1,2 and A. A. Shvedova 1,2 .<br />
1 2 HELD, NIOSH, Morgantown, WV, Physiology and<br />
Pharmacology, West Virginia University, Morgantown,<br />
WV, 3 Engineering Directorate, Materials and Processes,<br />
Lockheed Marting Corporation, Houston, TX and<br />
4 Nanotube Team, GBTech, Inc. NASA-JSC, Houston,<br />
TX.<br />
#1043 3:30 PULMONARY TOXICITY SCREENING STUDIES<br />
WITH NANO VS. FINE-SIZED QUARTZ AND<br />
TIO2 PARTICLES IN RATS. D. B. Warheit 1 , K.<br />
Reed 1 , T. Webb 1 , C. Sayes 2 and V. Colvin 2 . 1 DuPont<br />
Haskell Laboratory, Newark, DE and 2 Rice University,<br />
Houston, TX.<br />
#1044 3:50 DEVELOPMENT OF ANIMAL MODELS OF<br />
INHALATION FEVER USING FINE AND<br />
NANOPARTICLE ZINC OXIDE EXPOSURES. K.<br />
Reed, T. Webb and D. Warheit. DuPont Haskell<br />
Laboratory, Newark, DE.<br />
#1045 4:10 PULMONARY EXPOSURE TO CARBON<br />
NANOTUBES INDUCES VASCULAR TOXICITY.<br />
Z. Li, R. Salmen, T. Huldermen, E. Kisin, A. Shvedova,<br />
M. I. Luster and P. P. Simeonova. HELD/TMBB,<br />
NIOSH, Morgantown, WV.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Room RO6<br />
PLATFORM SESSION: LIVER<br />
Chairperson(s): Jose Manautou, University <strong>of</strong> Connecticut, Storrs, CT and<br />
Ivan Rusyn, University <strong>of</strong> North Carolina Chapel Hill, Chapel Hill, NC.<br />
#1046 1:30 TOXICOGENETIC AND TOXICOGENOMIC<br />
ANALYSIS OF ALCOHOL-INDUCED LIVER<br />
INJURY. I. Rusyn 1 , M. Lee 2 , W. Tak 1 , J. Milton 3 , B.<br />
Bradford 1 , A. Maki 1 , M. Wheeler 3 , D. Threadgill 4 and J.<br />
Marron 2 . 1 Environmental Sciences and Engineering,<br />
UNC-CH, Chapel Hill, NC, 2 Statistics and Operations<br />
Research, UNC-CH, Chapel Hill, NC, 3 Nutrition, UNC-<br />
CH, Chapel Hill, NC and 4 Genetics, UNC-CH, Chapel<br />
Hill, NC.<br />
#1047 1:50 EVIDENCE FOR OSTEOPONTIN INDUCTION IN<br />
VIVO AND IN VITRO: A POSSIBLE<br />
MECHANISM FOR HIGHER NEUTROPHIL<br />
TRANSMIGRATION AND HIGHER LIVER<br />
INJURY IN FEMALE ALCOHOLICS. A. Banerjee,<br />
U. M. Apte and S. K. Ramaiah. Pathobiology, Texas<br />
A&M University, College Station, TX.<br />
#1048 2:10 ACETAMINOPHEN (APAP) USE IN<br />
ALCOHOLICS: HEPATIC FUNCTION DURING<br />
AND FOLLOWING THERAPEUTIC DOSING. R.<br />
C. Dart 1 , J. L. Green 1 , E. K. Kuffner 1 , G. M. Bogdan 1 ,<br />
P. Knox 2 and E. Casper 1 . 1 Denver Health/Rocky<br />
Mountain Poison & Drug Center, Denver, CO and<br />
2 Recovery Centers <strong>of</strong> King County, Seattle, WA.<br />
#1049 2:30 PHENOBARBITAL AND PHENYTOIN INDUCED<br />
ACETAMINOPHEN HEPATOTOXICITY DUE TO<br />
DIRECT INHIBITION OF UGT1A6 AND UGT1A9.<br />
S. Kostrubsky 1 , S. C. Strom 2 , E. Urda 1 , S. Kulkarni 1 , J.<br />
F. Sinclair 3,5 and A. Mutlib 4 . 1 Safety Science, Pfizer,<br />
Ann Arbor, MI, 2 Pathology, Pitsburgh Medical School,<br />
Pittsburgh, PA, 3 Pharmcology/<strong>Toxicology</strong>, Dartmouth<br />
Medical School, Hanover, NH, 4 Pharmacokinetic,<br />
Dynamic and Metabolism, Pfizer, Ann Arbor, MI and<br />
5 Veterans Administration Medical Center, White River<br />
Jct, VT.<br />
130<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1050 2:50 GENDER DIFFERENCE OF ACETAMINOPHEN-<br />
INDUCED HEPATOTOXICITY IN MOUSE. G. Dai,<br />
N. Chou, L. He, M. Gyamfi, A. J. Mendy and Y. Y. Wan.<br />
Pharmacology, <strong>Toxicology</strong> and Therapeutics, University<br />
<strong>of</strong> Kansas Medical Center, Kansas City, KS.<br />
#1051 3:10 ALTERED HEPATOBILIARY DISPOSITION OF<br />
ACETAMINOPHEN GLUCURONIDE IN MRP3<br />
KNOCKOUT MICE AND THEIR<br />
SUSCEPTIBILITY TO HEPATOTOXICITY. J. E.<br />
Manautou 1 , R. de Waart 2 , N. Zelcer 3 , C. Kunne 2 , M.<br />
Goedken 1 , P. Borst 3 and R. Oude Elferink 2 .<br />
1 Department <strong>of</strong> Pharmaceutical Sciences, University <strong>of</strong><br />
Connecticut, Storrs, CT, 2 Liver Center, Academic<br />
Medical Center, Amsterdam, Netherlands and 3 The<br />
Netherlands Cancer Institute, Amsterdam, Netherlands.<br />
#1052 3:30 RAPID ACTIVATION OF WNT/β-CATENIN<br />
PATHWAY FOLLOWING ACETAMINOPHEN-<br />
INDUCED LIVER INJURY AND REGENRATION.<br />
U. M. Apte, A. Micsenyi and S. Monga. Department <strong>of</strong><br />
Pathology, University <strong>of</strong> Pittsburgh School <strong>of</strong> Medicine,<br />
Pittsburgh, PA.<br />
#1053 3:50 ROLE OF MITOCHONDRIAL BAX<br />
TRANSLOCATION IN ACETAMINOPHEN-<br />
INDUCED HEPATIC NECROSIS IN MICE. M.<br />
Bajt 1 , J. J. Lemasters 2 and H. Jaeschke 1 . 1 Liver<br />
Research Institute, University <strong>of</strong> Arizona, Tucson, AZ<br />
and 2 Cell and Developmental Biology, University <strong>of</strong><br />
North Carolina at Chapel Hill, Chapel Hill, NC.<br />
#1054 4:10 ACETAMINOPHEN-INDUCED UPREGULATION<br />
OF PI-3K AND NF-κB IN MOUSE LIVER:<br />
REGULATION BY TNFα AND CAVEOLIN-1. C.<br />
Gardner 1,3 , H. Chiu 1 , J. D. Laskin 2,3 and D. L. Laskin 1,3 .<br />
1 2 Rutgers University, Piscataway, NJ, UMDNJ-RWJ<br />
Med. School, Piscataway, NJ and 3 EOHSI, Piscataway,<br />
NJ.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: DEVELOPMENTAL NEUROTOXICITY II<br />
Chairperson(s): Merle Paule, U.S. FDA, Jefferson, AR and John Barnett, West<br />
Virginia University, Morgantown, WV.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1055 EXPOSURE TO METHYLMERCURY AND<br />
PCB153 DURING PREGNANCY AND<br />
LACTATION. EFFECTS ON BRAIN AND<br />
LYMPHOCYTE CHOLINERGIC MUSCARINIC<br />
RECEPTORS IN RAT DAMS AND PUPS. T.<br />
Coccini 1 , A. F. Castoldi 1 , G. Randine 1 , P. Grandjean 2<br />
and L. Manzo 1,3 . 1 <strong>Toxicology</strong> Division, Maugeri<br />
Foundation, Pavia, Italy, 2 University <strong>of</strong> Odense,<br />
Odense, Denmark and 3 University <strong>of</strong> Pavia, Pavia, Italy.<br />
#1056 DEVELOPMENTAL NEUROPATHOLOGY OF<br />
METHYL MERCURY CHLORIDE. D. M. de<br />
Groot 1 , B. Bisselink 1 , S. A. Hartgring 1 , L. van der<br />
Horst 1 , M. Pelgrim 1 , M. Waanders 1 , M. Kuijpers 1 , J.<br />
O’Callaghan 2 , W. Kaufmann 3 , J. Lammers 1 , B.<br />
Pakkenberg 4 , I. Waalkens 1 and H. Gundersen 5 . 1 TNO<br />
Nutrition and Food Research, Zeist, Netherlands,<br />
2 3 NIOSH, Morgantown, VA, BASF, Ludwigshafen,<br />
Germany, 4 Research Laboratory for Stereology and<br />
Neuroscience, Copenhagen, Denmark and 5 University<br />
<strong>of</strong> Aarhus, Aarhus, Denmark. Sponsor: V. Feron.<br />
#1057 PRENATAL EXPOSURE TO METHYL<br />
MERCURY OR METHYLAZOXY METHANOL:<br />
EFFECTS ON EARLY POSTNATAL MOTOR<br />
ACTIVITY. D. M. de Groot 1 , M. Kuijpers 1 , J.<br />
O’Callaghan 2 , M. van Dael 1 , H. Gundersen 3 , S.<br />
Hartgring 1 , L. van der Horst 1 , W. Kaufmann 4 , M. Otto 1 ,<br />
B. Pakkenberg 5 , M. Pelgrim 1 , I. Waalkens 1 and J.<br />
Lammers 1 . 1 TNO Nutrition and Food Research, Zeist,<br />
Netherlands, 2 NIOSH, Morgantown, VA, 3 University <strong>of</strong><br />
Aarhus, Aarhus, Denmark, 4 BASF, Ludwigshafen,<br />
Germany and 5 Research Laboratory for Stereology and<br />
Neuroscience, Copenhagen, Denmark. Sponsor: V.<br />
Feron.<br />
#1058 METHYLMERCURY (MEHG) ELICITS ACUTE<br />
AND LONG-TERM EFFECTS ON NEWBORN<br />
RAT HIPPOCAMPAL NEUROGENESIS<br />
THROUGH CELL CYCLE MACHINERY. K.<br />
Burke 1 , Y. Cheng 1 , K. Reuhl 2 , A. Petrov 1 and E.<br />
DiCicco-Bloom 1 . 1 Neurosci & Cell Biol, Robert Wood<br />
Johnson Med. Sch, Piscataway, NJ and 2 Pharmacol &<br />
<strong>Toxicology</strong>, Rutgers University, Piscataway, NJ.<br />
#1059 MEHG DIFFERENTIALLY AFFECTS KINETICS<br />
OF SIPSCS OF RAT CEREBELLAR PURKINJE<br />
AND GRANULE CELLS. Y. Yuan and W. D. Atchison.<br />
Pharmacology/<strong>Toxicology</strong>, Michigan State University,<br />
East Lansing, MI.<br />
#1060 GESTATIONAL LEAD EXPOSURE PRODUCES<br />
ROD-MEDIATED ELECTRORETINOGRAPHIC<br />
(ERG) SUPERNORMALITY AND DECREASES IN<br />
RETINAL DOPAMINE METABOLISM OF ADULT<br />
RATS. D. A. Fox 1 and S. Kala 2 . 1 University <strong>of</strong><br />
Houston, Houston, TX and 2 Baylor College <strong>of</strong><br />
Medicine, Houston, TX.<br />
#1061 GESTATIONAL LEAD EXPOSURE PRODUCES A<br />
SELECTIVE DECREASE IN MOUSE RETINAL<br />
DOPAMINERGIC AMACRINE CELL DENSITY<br />
AND DISTRIBUTION. J. E. Johnson, A.<br />
Giddabasappa, Q. Chen and D. A. Fox. University <strong>of</strong><br />
Houston, Houston, TX.<br />
#1062 DEVELOPMENTAL EXPOSURE TO LEAD<br />
ELEVATES APP AND AβLEVELS IN THE AGING<br />
BRAIN BUT DOES NOT ALTER THE<br />
PROTEOLYTIC PROCESSING OF APP. M. Basha,<br />
M. Murali, W. Wei, H. K. Siddiqi and N. H. Zawia.<br />
Biomediacl and Pharmaceutical Sciences, University <strong>of</strong><br />
Rhode Island, Kingston, RI.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 131
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1063 DEVELOPMENTAL EXPOSURE TO LEAD<br />
MODULATES THE OCT-2 TRANSCRIPTION<br />
FACTOR AND ITS TARGET GENES IN THE RAT<br />
HIPPOCAMPUS. S. A. Bakheet and N. H. Zawia.<br />
Biomediacl and Pharmaceutical Sciences, University <strong>of</strong><br />
Rhode Island, Kingston, RI.<br />
#1064 MODULATION OF BRAIN CYTOKINE GENE<br />
EXPRESSION BY LEAD. J. Kasten-Jolly, N. Pabello<br />
and D. A. Lawrence. Wadsworth Center, Albany, NY.<br />
#1065 NMDAR SUBUNITS WERE AGGRESSIVELY<br />
REDUCED BY PB-EXPOSURE IN THE EARLY<br />
DEVELOPMENT OF RAT BRAIN. S. xu and B.<br />
Rajanna. Alcorn State University, Alcorn state, MS.<br />
#1066 PRENATAL EXPOSURE TO INHALED<br />
MANGANESE ALTERS DOPAMINERGIC<br />
SUSCEPTIBILITY TO POSTNATAL<br />
METHAMPHETAMINE NEUROTOXICITY. A.<br />
rinderknecht 1 and M. T. Kleinman 2 . 1 Environmental<br />
Health Science and Policy, Univeristy <strong>of</strong> California,<br />
Irvine, Irvine, CA and 2 Community and Environmental<br />
Medicine, University <strong>of</strong> California, Irvine, Irvine, CA.<br />
#1067 EFFECTS OF PRENATAL EXPOSURE OF MICE<br />
TO CHROMIUM PICOLINATE, CHROMIUM<br />
CHLORIDE, OR PICOLINIC ACID. M. M. Bailey 1 ,<br />
R. D. Hood 2,1 , J. F. Rasco 1 , J. G. Boohaker 1 , V. Stegall 1 ,<br />
J. J. Jernigan 3 and J. B. Vincent 4 . 1 Department <strong>of</strong><br />
Biological Sciences, The University <strong>of</strong> Alabama,<br />
Tuscaloosa, AL, 2 Ronald D. Hood & Associates,<br />
<strong>Toxicology</strong> Consultants, Tuscaloosa, AL, 3 Department<br />
<strong>of</strong> Biology, Stillman College, Tuscaloosa, AL and<br />
4 Department <strong>of</strong> Chemistry, The University <strong>of</strong> Alabama,<br />
Tuscaloosa, AL.<br />
#1068 DEXAMETHASONE ALTERS NEURONAL<br />
DEVELOPMENT: CELL ACQUISITION AND<br />
DIFFERENTIATION IN PC12 CELLS. R. R.<br />
Jameson, F. J. Seidler and T. A. Slotkin.<br />
Pharmacol/Cancer Biol, Duke U Med. Ctr, Durham,<br />
NC.<br />
#1069 PRENATAL OR NEONATAL GLUCOCORTICOID<br />
TREATMENT, AT DOSES COMMENSURATE<br />
WITH PHARMACOTHERAPY IN PRETERM<br />
INFANTS, DISRUPTS BRAIN DEVELOPMENT<br />
AND EVOKES LASTING BEHAVIORAL<br />
ABNORMALITIES. M. L. Kreider, E. D. Levin, F. J.<br />
Seidler and T. A. Slotkin. Pharmacology & Cancer<br />
Biology, Duke University Med. Ctr, Durham, NC.<br />
#1070 PERSISTING BEHAVIORAL CONSEQUENCES<br />
OF PRENATAL DOMOIC ACID EXPOSURE IN<br />
RATS. E. D. Levin 1 , K. Pizarro 1 , J. Harrison 1 , W. Pang 1<br />
and J. S. Ramsdell 2 . 1 Department <strong>of</strong> Psychiatry and<br />
Behavioral Sciences, Duke University Med. Ctr,<br />
Durham, NC and 2 Marine Biotoxins <strong>Program</strong>, NOAA-<br />
National Ocean Service, Charleston, SC.<br />
#1071 PERINATAL PERCHLORATE EXPOSURE IN<br />
THE RAT: DOES THYROID STATUS AFFECT<br />
BRAIN MORPHOMETRY? S. Schettler 1 , M. R.<br />
Seeley 1 , T. A. Lewandowski 2 and B. D. Beck 1 . 1 Gradient<br />
Corporation, Cambridge, MA and 2 Gradient<br />
Corporation, Seattle, WA.<br />
#1072 BEHAVIORAL EFFECTS ASSOCIATED WITH<br />
CHRONIC DEVELOPMENTAL EXPOSURE TO<br />
KETAMINE OR REMACEMIDE IN RATS. L. K.<br />
Wright 2,1 , C. M. Fogle 1 , E. Pearson 3 , T. Hammond 3 and<br />
M. G. Paule 1,2 . 1 Division <strong>of</strong> Neurotoxicology, NCTR,<br />
Jefferson, AR, 2 Department <strong>of</strong> Pharmacology and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Arkansas for Medical<br />
Sciences, Little Rock, AR and 3 AstraZeneca Safety<br />
Assessment, Leics, United Kingdom.<br />
#1073 EXPOSURE TO KETAMINE DURING<br />
NEONATAL LIFE INDUCES TRIGGERED<br />
APOPTOTIC NEURODEGENERATION AND<br />
BEHAVIOURAL DEFICITS IN ADULTHOOD. F.<br />
Anders 1 , E. Ponten 2 , T. Gordh 2 and P. Eriksson 1 .<br />
1 Department <strong>of</strong> Environmental <strong>Toxicology</strong>, Uppsala<br />
University, Uppsala, Sweden and 2 Department <strong>of</strong><br />
Anaesthesiology, Uppsala University, Uppsala, Sweden.<br />
#1074 DEVELOPMENTAL TOXICOLOGY IN THE<br />
NEONATAL MOUSE: THE USE OF RANDOMLY<br />
SELECTED INDIVIDUALS AS STATISTICAL<br />
UNIT COMPARED TO THE LITTER IN MICE<br />
NEONATALLY EXPOSED TO PBDE 99. P.<br />
Eriksson 1 , D. von Rosen 2 , H. Viberg 1 and A.<br />
Fredriksson 1 . 1 Department <strong>of</strong> Environmental<br />
<strong>Toxicology</strong>, Uppsala University, Uppsala, Sweden and<br />
2 Department <strong>of</strong> Biometry and Engineering, Swedish<br />
University <strong>of</strong> Agricultural Sciences, Uppsala, Sweden.<br />
#1075 POSTNATAL DEVELOPMENTAL<br />
NEUROTOXICITY (DNT): EVALUATION OF P-<br />
MENTHANE 3, 8, DIOL BY DERMAL<br />
ADMINISTRATION IN NEONATAL RATS. J. F.<br />
Barnett 1 , D. B. Learn 1 , A. M. Hoberman 1 , U. Vedula 2<br />
and T. G. Osimitz 3 . 1 Center for Photobiology, Charles<br />
River Discovery and Development Services, Argus<br />
Division, Horsham, PA, 2 S.C. Johnson & Sons, Inc.,<br />
Racine, WI and 3 Science Strategies, LLC,<br />
Charlottesville, VA.<br />
#1076 WATER DISINFECTANT BYPRODUCTS (DBP)<br />
AND ADVERSE PREGNANCY OUTCOMES<br />
(APO): CHLOROACETONITRILE (CAN)<br />
INDUCES GROWTH RESTRICTION AND<br />
ALTERS GENE EXPRESSION IN FETAL BRAIN.<br />
S. Jacob 1 , T. Wood 2 , H. Fouad 1 and A. E. Ahmed 1 .<br />
1 Pathology, University <strong>of</strong> TX Medical Brach,<br />
Galveston, TX and 2 Molecular Genomics, University <strong>of</strong><br />
TX Medical Brach, Galveston, TX.<br />
#1077 METHAMPHETAMINE-INITIATED<br />
NEURODEVELOPMENTAL DEFICITS ARE<br />
ENHANCED IN COCKAYNE SYNDROME B (CSB)<br />
KNOCKOUT MICE. A. W. Wong 1 , W. Jeng 1 and P. G.<br />
Wells 1,2 . 1 Faculty <strong>of</strong> Pharmacy, University <strong>of</strong> Toronto,<br />
Toronto, ON, Canada and 2 Department <strong>of</strong><br />
Pharmacology, University <strong>of</strong> Toronto, Toronto, ON,<br />
Canada.<br />
#1078 PERINATAL DIMETHYLTIN EXPOSURE<br />
ALTERS SPATIAL LEARNING ABILITY IN<br />
ADULT RATS. K. D. Ehman 1 , K. L. McDaniel 2 , P. M.<br />
Phillips 2 and V. C. Moser 2 . 1 Curriculum in <strong>Toxicology</strong>,<br />
UNC, Chapel Hill, NC and 2 NTD/NHEERL, U.S. EPA,<br />
Research Triangle Park, NC.<br />
132<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1079 PERTURBATION OF NEURAL CELL DAMAGE<br />
RESPONSE SENSITIZES NRF2 KO MICE,<br />
INCREASING THE DURATION AND SEVERITY<br />
OF KAINATE-INDUCED SEIZURES. A. D. Kraft 1 ,<br />
J. Lee 2 and J. A. Johnson 1,3,4 . 1 Pharmacy, University <strong>of</strong><br />
Wisconsin, Madison, WI, 2 Mass General Hospital,<br />
Boston, MA, 3 Waisman Center, University <strong>of</strong><br />
Wisconsin, Madison, WI and 4 <strong>Toxicology</strong>, University <strong>of</strong><br />
Wisconsin, Madison, WI.<br />
#1080 EFFECTS OF PERINATAL EXPOSURE TO PCB<br />
153 ON THE TURNOVER OF BRAIN<br />
NEUROTRANSMITTERS OF OFFSPRING RATS.<br />
T. Honma, M. Miyagawa, R. Wang, M. Suda and K.<br />
Kobayashi. Department <strong>of</strong> Research Planning, National<br />
Institute <strong>of</strong> Industrial Health, Kawasaki, Japan. Sponsor:<br />
M. Chiba.<br />
#1081 CHANGES IN GENE EXPRESSION PROFILE IN<br />
THE CEREBELLUM AND THE HIPPOCAMPUS<br />
FOLLOWING DEVELOPMENTAL EXPOSURE<br />
TO A NEUROTOXICANT. P. R. Kodavanti, T. R.<br />
Ward and J. E. Royland. Neurotoxicology Division,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#1082 EFFECTS OF PCB 84 ATROPISOMERS ON [ 3 H]<br />
PHORBOL ESTER BINDING IN RAT<br />
CEREBELLAR GRANULE CELLS AND 45 CA 2+ -<br />
UPTAKE IN RAT CEREBELLUM. H. Lehmler 1 , L.<br />
W. Robertson 1 , A. Garrison 2 and P. S. Kodavanti 3 .<br />
1 Occupational and Environmental Health, University <strong>of</strong><br />
Iowa, Iowa City, IA, 2 National Exposure Research<br />
Laboratory, Ecosystems Research Division, U.S. EPA,<br />
Athens, GA and 3 Neurotoxicology Division, Cellular<br />
and Molecular <strong>Toxicology</strong> Branch, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1083 PCBs REDUCE THE NUMBER OF DOPAMINE<br />
NEURONS AND INDUCE NEURONAL CELL<br />
DEATH IN ORGANOTYPIC CO-CULTURES OF<br />
DEVELOPING RAT STRIATUM AND<br />
SUBSTANTIA NIGRA. G. D. Lyng 2 , A. Snyder-<br />
Keller 1,2 and R. F. Seegal 1,2 . 1 NYS Department <strong>of</strong><br />
Health, Wadsworth Center, Albany, NY and<br />
2 Biomedical Sciences, School <strong>of</strong> Public Health,<br />
University at Albany, Albany, NY.<br />
#1084 ALTERED COGNITIVE FUNCTION AND<br />
DENDRITIC GROWTH IN WEANLING RATS<br />
EXPOSED DEVELOPMENTALLY TO AROCLOR<br />
1254. D. Yang and P. Lein. CROET, Oregon Health &<br />
Science University, Portland, OR.<br />
#1085 DEVELOPMENTAL EXPOSURE TO PCBs<br />
CAUSES AUDITORY IMPAIRMENTS IN RATS. B.<br />
E. Powers 1 , J. J. Widholm 2 , D. M. Gooler 1 , R. E.<br />
Lasky 3 and S. L. Schantz 1 . 1 Neuroscience, University <strong>of</strong><br />
Illinois, Urbana, IL, 2 Psychology, College <strong>of</strong><br />
Charleston, Charleston, SC and 3 Health Science Center,<br />
University <strong>of</strong> Texas, Houston, TX.<br />
#1086 PCB INDUCED HYPOTHYROXINEMIA ALTERS<br />
OLIGODENDROCYTE NUMBERS IN TWO<br />
WHITE MATTER TRACTS OF THE<br />
DEVELOPING RAT BRAIN. D. Sharlin, R. Bansal<br />
and R. Zoeller. Biology Department, University <strong>of</strong><br />
Massachusetts, Amherst, MA.<br />
#1087 VITAMIN A HOMEOSTASIS IS DISRUPTED IN<br />
OFFSPRING OF RAT DAMS EXPOSED TO<br />
PBDES DURING GESTATION AND LACTATION.<br />
R. Ellis-Hutchings, G. N. Cherr and C. L. Keen.<br />
Nutrition, University <strong>of</strong> California-Davis, Davis, CA.<br />
#1088 TCDD MODULATES GENE EXPRESSION<br />
ASSOCIATED WITH CEREBELLAR GRANULE<br />
NEURON MIGRATION AND<br />
DIFFERENTIATION. M. Williamson and L.<br />
Opanashuk. Department Environmental Medicine,<br />
University <strong>of</strong> Rochester, Rochester, NY.<br />
#1089 DEVELOPMENT OF A QUANTITATIVE ASSAY<br />
FOR DETERMINATION OF TCDD TOXIC<br />
EQUIVALENTS IN F1 GENERATION CNS<br />
TISSUES. L. Brown 1 , E. Harris 2 , A. Smith 3 , J. Wu 1 , S.<br />
Johnson 1 and D. B. Hood 1 . 1 Department <strong>of</strong><br />
Pharmacology & Center in Molecular and Behavioral<br />
Neuroscience, Meharry Medical College, Nashville, TN,<br />
2 Department <strong>of</strong> Biology, Xavier University <strong>of</strong><br />
Louisianna, New Orleans, LA and 3 Department <strong>of</strong><br />
Biology, Alabama A & M University, Huntsville, AL.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NERVOUS SYSTEM: METHODS AND<br />
FUNCTIONAL EFFECTS<br />
Chairperson(s): David W. Herr, U.S. EPA, Research Triangle Park, NC and<br />
Syed F. Ali, NCTR FDA, Little Rock, AR.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1090 THE RETURN OF THE “DARK” NEURON. A<br />
HISTOLOGICAL ARTIFACT COMPLICATING<br />
NEUROTOXICOLOGIC INTERPRETATION. B. S.<br />
Jortner. Laboratory for Neurotoxicity Studies, Virginia<br />
Tech, Blacksburg, VA.<br />
#1091 TEN-DAY EXPOSURE TO CARBONYL SULFIDE<br />
PRODUCE BRAINSTEM LESIONS AND<br />
CHANGES IN BRAINSTEM AUDITORY EVOKED<br />
RESPONSES IN FISCHER 344N RATS. D. W.<br />
Herr 1 , J. E. Graff 1 , P. B. Little 2 , V. C. Moser 1 , P. M.<br />
Phillips 1 , K. M. Cr<strong>of</strong>ton 1 , D. L. Morgan 3 and R. C.<br />
Sills 3 . 1 NTD, U.S. EPA, Research Triangle Park, NC,<br />
2 3 PAI, Research Triangle Park, NC and NIEHS,<br />
Research Triangle Park, NC.<br />
#1092 SELECTIVE NEURONAL DEGENERATION IN<br />
THE CENTRAL NERVOUS SYSTEM OF RATS<br />
EXPOSED TO 3, 3’-IMINODIPROPIONITRILE<br />
(IDPN), ALLYLNITRILE (AN), CIS-<br />
CROTONONITRILE (CIS-CN), TRANS-<br />
CROTONONITRILE (TRANS-CN) AND 2, 4-<br />
HEXADIENENITRILE (HDN). J. Llorens and P.<br />
Boadas-Vaello. D. Ciencies Fisiologiques II, Universitat<br />
de Barcelona, Hospitalet de Llobregat, Catalunya,<br />
Spain. Sponsor: K. Cr<strong>of</strong>ton.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 133
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1093 NORMAL VISUAL CONTRAST SENSITIVITY<br />
(VCS) AND COLOR VISION OF ADULTS AND<br />
SCHOOL-AGE CHILDREN FOUR TO FIVE<br />
YEARS AFTER EXPOSURE TO<br />
PERCHLOROETHYLENE (PERC). K. A. Mazor 1 ,<br />
R. L. Shultz 2 , M. Meldrum 1 , E. Lewis-Michl 1 , L.<br />
Gensburg 1 and J. E. Storm 1 . 1 Department <strong>of</strong> Health,<br />
New York State, Troy, NY and 2 Cornea Consultants <strong>of</strong><br />
Albany, Slingerlands, NY.<br />
#1094 NEW ASSESSMENT OF NEUROBEHAVIORAL<br />
CHANGES USING FUNCTIONAL<br />
OBSERVATIONAL BATTERY (FOB) IN<br />
MONKEYS. T. yoshikawa, Y. Deguchi, R. Anraku, K.<br />
Fukuzaki, G. Kito and R. Nagata. shin Nippon<br />
Biomedical Laboratories, Ltd., (SNBL), Yoshida,<br />
Kagoshima, Japan.<br />
#1095 NEUROBEHAVIORAL ASSESSMENT OF SIX<br />
NEUROTOXICANTS IN MALE SPRAGUE-<br />
DAWLEY RATS. K. Steinmetz, L. Rausch, A. Robb, G.<br />
Ganem, D. Lau, D. Middaugh and J. Mirsalis. SRI Int,<br />
Menlo Park, CA.<br />
#1096 ASSESSMENT OF NEUROTOXICITY USING<br />
ZEBRAFISH AS A MODEL ORGANISM. N. Roy,<br />
C. Ton, Y. Lin and C. Parng. Phylonix Pharmaceuticals,<br />
Inc., Cambridge, MA. Sponsor: D. Monteith.<br />
#1097 SENSITIVE DETECTION OF BEHAVIORAL<br />
IMPAIRMENTS IN MODERATELY LESIONED<br />
MPTP MICE BY AUTOMATED GAIT ANALYSIS.<br />
T. Guillot 1 , J. R. Richardson 1,2 and G. W. Miller 1,2 .<br />
1 Center for Neurodegenerative Disease, Atlanta, GA and<br />
2 2Environmental and Occupational Health, Rollins<br />
School <strong>of</strong> Public Health, Atlanta, GA.<br />
#1098 ALTERATIONS OF GENE EXPRESSION IN<br />
MICE INDUCED BY MPTP ADMINISTRATION:<br />
APPLICATION OF MICROARRAY ANALYSIS. Z.<br />
A. Xu 1 , D. R. Cawthon 1 , T. Han 2 , T. A. Patterson 1 , L.<br />
Shi 2 , H. Fang 3 , S. Ali 1 and W. Slikker 1 .<br />
1 2 Neurotoxicology, NCTR, Jefferson, AR, System<br />
<strong>Toxicology</strong>, NCTR, Jefferson, AR and 3 Division <strong>of</strong><br />
Bioinformatics, Z-Tech Corporation, NCTR, Jefferson,<br />
AR.<br />
#1099 MICROARRAY ANALYSIS DETECTED GENE<br />
EXPRESSION CHANGES IN PC12 CELLS AFTER<br />
EXPOSURE TO THE NEUROTOXIN MPP + S. F.<br />
Ali 1 , Z. A. Xu 1 , T. Han 2 , T. A. Patterson 1 , L. Shi 2 , H.<br />
Fang 3 , D. R. Cawthon 1 and W. Slikker 1 .<br />
1 2 Neurotoxicology, NCTR, Jefferson, AR, Systems<br />
<strong>Toxicology</strong>, NCTR, Jefferson, AR and 3 Division <strong>of</strong><br />
Bioinformatics, Z-Tech Corporation, NCTR, Jefferson,<br />
AR.<br />
#1100 COMPARISON OF MEMBRANE POTENTIAL-<br />
SENSITIVE FLUORESCENT DYES FOR<br />
MEASUREMENT OF TOXIN-INDUCED<br />
DEPOLARIZATION IN MURINE NEOCORTICAL<br />
NEURONS: CHARACTERIZATION OF<br />
BREVETOXIN-AND KCL-INDUCED<br />
DEPOLARIZATION. J. H. Peterson and T. F. Murray.<br />
Physiology and Pharmacology, University <strong>of</strong> Georgia,<br />
Athens, GA.<br />
#1101 BREVENOL, A NATURAL BREVETOXIN<br />
ANTAGONIST: COMPETITIVE ANTAGONIST<br />
OR ALLOSTERIC MODULATOR? E. P. Gold 1,2 , H.<br />
Jacocks 2 , A. J. Bourdelais 2 and D. G. Baden 2,1 .<br />
1 Biological Sciences, UNCW, Wilmington, NC and<br />
2 Center for Marine Science, UNCW, Wilmington, NC.<br />
#1102 FEASIBILITY OF CONTINUOUS<br />
INTRACEREBRO-VENTRICULAR (ICV)<br />
INFUSION IN THE RAT FOR 28 DAYS. K.<br />
Tenneson and C. Copeman. <strong>Toxicology</strong>, CTBR,<br />
Senneville, QC, Canada. Sponsor: M. Vezina.<br />
#1103 TEMPORAL ANALYSIS OF OPIATE-INDUCED<br />
INTRATHECAL GRANULOMATUS MASSES<br />
PROGRESSION AND REGRESSION USING MRI.<br />
J. W. Allen 1 , K. Horais 1 , N. Tozier 1 , J. Corbeil 2 , R. F.<br />
Mattrey 2 and T. L. Yaksh 1 . 1 Anesthesiology, University<br />
CA-San Diego, La Jolla, CA and 2 Radiology, University<br />
CA-San Diego, La Jolla, CA.<br />
#1104 A COMPARATIVE EVALUATION OF ANIMAL<br />
CHARACTERISTICS AND DEVELOPMENT OF<br />
CHOROIDAL NEOVASCULARIZATION (CNV)<br />
IN A LASER-INDUCED NON-HUMAN PRIMATE<br />
MODEL OF MACULAR DEGENERATION. M.<br />
Wills. Development and Discovery Services, Charles<br />
River Laboratories, Sparks, NV.<br />
#1105 ALZHEIMER’S DISEASE: THE CYNOMOLGUS<br />
MONKEY AS A MODEL IN TOXICOLOGICAL<br />
RESEARCH? E. Buse, G. Habermann, S. Friderichs-<br />
Gromoll, J. Kaspareit and P. Nowak. Covance<br />
Laboratories GmbH, 48163 Muenster, Germany.<br />
Sponsor: G. Weinbauer.<br />
#1106 EXPERIMENTAL ALLERGIC<br />
ENCEPHALOMYELITIS (EAE) IN THE FEMALE<br />
LEWIS RAT. S. Rowton and S. Grainger. Covance<br />
Laboratories Ltd., Harrogate, United Kingdom.<br />
Sponsor: D. Everett.<br />
#1107 ANALYSIS OF MYELIN LOSS USING<br />
SCANNING ELECTRON MICROSCOPY (SEM)<br />
UNDER FULLY HYDRATED CONDITIONS:<br />
VALIDATION IN A MOUSE MODEL OF<br />
EXPERIMENTAL AUTOIMMUNE<br />
ENCEPHALITIS. V. Behar 3 , E. Blaugrund 3 , A.<br />
Mayk 3 , E. Raymond 3 , N. Russek 2 , M. Horowitz 2 and A.<br />
Nyska 1 . 1 Laboratory <strong>of</strong> Experimental Pathology,<br />
NIEHS, Research Triangle Park, NC, 2 QuantomiX,<br />
Ltd.,, Ness Ziona, Israel and 3 Research & Development,<br />
Teva Pharmaceuticals Ltd.,, Sapir Industrial Zone,<br />
Israel.<br />
134<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: FEMALE REPRODUCTIVE<br />
Chairperson(s): Moussa Diawara, University <strong>of</strong> Southern Colorado, Pueblo,<br />
CO and Ulrike Luderer, University <strong>of</strong> California Irvine, Irvine, CA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1108 NEONATAL/PREPUBERTAL EXPOSURE TO<br />
BUTYL BENZYL PHTHALATE, BUT NOT<br />
BISPHENOL A, CAUSES SUBTLE ALTERATIONS<br />
TO THE RAT FEMALE REPRODUCTIVE<br />
TRACT. C. A. Lamartiniere and E. Abdalla.<br />
Pharmacology and <strong>Toxicology</strong>, University Alabama at<br />
Birmingham, Birmingham, AL.<br />
#1109 THE ARYL HYDROCARBON RECEPTOR (AHR)<br />
IS REQUIRED FOR NORMAL OVULATION IN<br />
THE MOUSE. D. Tomic, C. Greenfeld, J. K. Babus<br />
and J. A. Flaws. Epidemiology, University <strong>of</strong> Maryland<br />
School <strong>of</strong> Medicine, Baltimore, MD.<br />
#1110 EFFECTS OF ESTROGEN RECEPTOR<br />
MODULATORS ON UTERINE PATHOLOGY AND<br />
GENE EXPRESSION. D. T. Gray 1 , J. A. Styles 1 , P.<br />
Greaves 2 and I. N. White 1 . 1 Cancer Studies and<br />
Molecular Medicine, MRC Molecular Endocrinology<br />
Group, Leicester, United Kingdom and 2 MRC<br />
<strong>Toxicology</strong> Unit, University <strong>of</strong> Leicester, Leicester,<br />
United Kingdom. Sponsor: A. Smith.<br />
#1111 THE ARYL HYDROCARBON RECEPTOR (AHR)<br />
REDUCES EXPRESSION OF ENZYMES IN THE<br />
ESTROGEN BIOSYNTHESIS PATHWAY. C. B.<br />
Mainor 1 , K. Barnett 2 , D. Tomic 2 and J. Flaws 2 .<br />
1 University <strong>of</strong> Maryland Baltimore County, Baltimore,<br />
MD and 2 University <strong>of</strong> Maryland School <strong>of</strong> Medicine,<br />
Baltimore, MD.<br />
#1112 THE ARYL HYDROCARBON RECEPTOR (AHR)<br />
REGULATES OVARIAN FOLLICLE GROWTH<br />
IN VITRO. K. Barnett, D. Tomic and J. Flaws.<br />
University <strong>of</strong> Maryland School <strong>of</strong> Medicine, Baltimore,<br />
MD.<br />
#1113 ACTIVATION OF TH1 PRO-INFLAMMATORY<br />
CYTOKINE EXPRESSION BY ARYL<br />
HYDROCARBON RECEPTOR (AHR) LIGANDS<br />
IN HUMAN UTERINE ENDOMETRIAL CELLS.<br />
K. Shiverick 1 , T. Medrano 1 , N. Chegini 2 and M. James 3 .<br />
1 Department <strong>of</strong> Pharmacology & Therapeutics,<br />
University <strong>of</strong> Florida, Gainesville, FL, 2 Department <strong>of</strong><br />
Obstetrics & Gynecology, University <strong>of</strong> Florida,<br />
Gainesville, FL and 3 Department <strong>of</strong> Medicinal<br />
Chemistry, University <strong>of</strong> Florida, Gainesville, FL.<br />
#1114 STIMULATORY AND INHIBITORY EFFECTS OF<br />
GENISTEIN ON UTERINE LEIOMYOMA CELL<br />
GROWTH IN VITRO IS DETERMINED BY DOSE.<br />
L. Castro, A. Moore, L. Yu, C. Bortner, M. Sifre, R.<br />
Newbold and D. Dixon. NIEHS, Research Triangle<br />
Park, NC.<br />
#1115 SUPEROXIDE ANION, HYDROGEN PEROXIDE,<br />
AND HYDROXYL RADICALS IN CIGARETTE<br />
SMOKE INHIBIT HAMSTER OOCYTE<br />
CUMULUS COMPLEX PICKUP. C. Gieseke, R.<br />
Pederson and P. Talbot. Cell Biology and Neuroscience,<br />
University <strong>of</strong> California, Riverside, Riverside, CA.<br />
Sponsor: B. Krieger.<br />
#1116 CHARACTERIZING THE OVOTOXICITY OF<br />
CYCLOPHOSPHAMIDE METABOLITES ON<br />
CULTURED MOUSE OVARIES IN VITRO. P. J.<br />
Devine. Institut Armand-Frappier, Institut national de la<br />
recherche scientifique, Pointe Claire, QC, Canada.<br />
#1117 EFFECTS OF BUTHIONINE SULFOXIMINE<br />
TREATMENT ON THE EXPRESSION OF<br />
GLUTAMATE CYSTEINE LIGASE SUBUNITS IN<br />
THE RAT OVARY. Y. D. Hoang 1 , A. P. Avakian 2 and<br />
U. Luderer 2,1,3 . 1 Community and Environmental<br />
Medicine, University <strong>of</strong> California Irvine, Irvine, CA,<br />
2 Medicine, University <strong>of</strong> California Irvine, Irvine, CA<br />
and 3 Developmental and Cell Biology, University <strong>of</strong><br />
California Irvine, Irvine, CA.<br />
#1118 CUMULATIVE EFFECTS OF THIRAM AND<br />
AMITRAZ ON PREGNANCY MAINTENANCE<br />
AND DEVELOPMENT IN THE RAT. D. S. Best, M.<br />
G. Narotsky and R. L. Cooper. Reproductive<br />
<strong>Toxicology</strong> Division, U.S. EPA, ORD, NHEERL,<br />
Research Triangle Park, NC. Sponsor: T. Stoker.<br />
#1119 DIBROMOACETIC ACID ATTENTUATES A<br />
DITHIOCARBAMATE-INDUCED SUPPRESSION<br />
OF THE LH SURGE IN THE RAT. J. M. Goldman,<br />
A. S. Murr, A. R. Buckelew, W. McElroy and J. M.<br />
Ferrell. Endocrinol. Br., RTD, NHEERL, ORD, U.S.<br />
EPA, Res. Triangle Pk., NC. Sponsor: A. Cummings.<br />
#1120 A SINGLE DOSE OF 8-METHOXYPSORALEN<br />
REDUCES LUTEINIZING HORMONE LEVELS<br />
IN FEMALE RATS. M. M. Diawara 1 and P. B.<br />
Hoyer 2 . 1 Biology, Colorado State University-Pueblo,<br />
Pueblo, CO and 2 Physiology, University <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
#1121 EFFECTS OF FEED RESTRICTION ON<br />
FERTILITY AND EARLY EMBRYONIC<br />
DEVELOPMENT IN FEMALE RATS. M. S.<br />
Gilman, T. L. Fleeman, R. E. Chapin, M. E. Hurtt and<br />
K. K. Terry. Pfizer Global Research & Development,<br />
Pfizer Inc., Groton, CT.<br />
#1122 LATE GESTATIONAL ATRAZINE EXPOSURE<br />
ALTERS MATERNAL NURSING BEHAVIOR IN<br />
RATS. J. L. Rayner 1 and S. E. Fenton 2 . 1 DESE, UNC-<br />
Chapel Hill, Chapel Hill, NC and 2 RTD, NHEERL,<br />
ORD, U.S. EPA, Research Triangle Park, NC.<br />
#1123 PERIPHERAL BENZODIAZEPINE RECEPTOR<br />
LIGAND PK11195 AFFECTS FEMALE<br />
FERTILITY AS DEMONSTRATED IN AN IN-<br />
VITRO MOUSE FOLLICLE BIOASSAY. E.<br />
Gobbers 1 , K. Van Wemmel 1 , J. Smitz 2 and R.<br />
Cortvrindt 1,2 . 1 EggCentris NV, Zellik, Belgium and<br />
2 Follicle Biology Laboratory, Vrije Universiteit Brussel,<br />
Brussels, Belgium. Sponsor: R. De Coster.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 135
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: METALS TOXICOLOGY<br />
Chairperson(s): Elaine M. Faustman, Institute for Risk Analysis & Risk<br />
Communication, Seattle, WA and Donald Sens, University <strong>of</strong> North Dakota,<br />
Grand Forks, ND.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1124 THE CHEMICAL FORM OF ALUMINUM<br />
AFFECTS ITS PARACELLULAR FLUX ACROSS<br />
AND UPTAKE INTO CACO-2 CELLS. Y. Zhou 1 and<br />
R. A. Yokel 2,1 . 1 Graduate Center for <strong>Toxicology</strong>,<br />
University <strong>of</strong> Kentucky, Lexington, KY and 2 College <strong>of</strong><br />
Pharmacy, University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1125 ORAL ALUMINUM (AL) BIOAVAILABILITY<br />
FROM A FOOD CONTAINING AN AL FOOD<br />
ADDITIVE: RELEVANCE TO THE MAJOR<br />
SOURCES OF AL EXPOSURE FOR HUMANS. R.<br />
A. Yokel 1,2 and R. L. Florence 1 . 1 College <strong>of</strong> Pharmacy,<br />
University <strong>of</strong> Kentucky Medical Center, Lexington, KY<br />
and 2 Graduate Center for <strong>Toxicology</strong>, University <strong>of</strong><br />
Kentucky Medical Center, Lexington, KY.<br />
#1126 DOES ALUMINUM WELDING FUME CAUSE<br />
CLINICALLY SIGNIFICANT PNEUMOCONIOSIS<br />
AND LUNG CANCER?–AN ANALYSIS OF<br />
SPECIFIC CAUSATION. N. Zheng and B. Thomas.<br />
Risk Assessment and Management Group, Inc.,<br />
Houston, TX. Sponsor: A. Jabbour.<br />
#1127 PHYSICAL AND CHEMICAL<br />
CHARACTERIZATION OF BERYLLIUM<br />
PARTICLES FROM SEVERAL WORKPLACES IN<br />
QUEBEC–PART A: DETERMINING METHODS<br />
FOR THE ANALYSIS OF LOW LEVELS OF<br />
BERYLLIUM. J. Zayed 1 , M. Rouleau 1 , C. Dion 2 , P.<br />
Plamondon 3 , G. Kennedy 4 and G. L’Esperance 3 .<br />
1 Environmental and occupational Health, University <strong>of</strong><br />
Montreal, Montreal, QC, Canada, 2 Institut de recherche<br />
Robert-Sauve en sante et en securite du travail,<br />
Montreal, QC, Canada, 3 Centre for Characterization and<br />
Microscopy <strong>of</strong> Materials, Polytechnique School,<br />
Montreal, QC, Canada and 4 Physic Engineer,<br />
Polytechnique School, Montreal, QC, Canada.<br />
#1128 PHYSICAL AND CHEMICAL<br />
CHARACTERIZATION OF BERYLLIUM<br />
PARTICLES FROM SEVERAL WORKPLACES IN<br />
QUEBEC, CANADA. PART B: TIME-OF-FLIGHT<br />
SECONDARY ION MASS SPECTROSCOPY. J.<br />
Zayed 1 , M. Rouleau 1 , C. Dion 2 , P. Plamondon 3 and G.<br />
L’Esperance 3 . 1 Environmental and occupational Health,<br />
University <strong>of</strong> Montreal, Montreal, QC, Canada, 2 Institut<br />
de recherche Robert-Sauve en sante et en securite du<br />
travail, Montreal, QC, Canada and 3 Centre for<br />
Characterization and Microscopy <strong>of</strong> Materials,<br />
Polytechnique School, Montreal, QC, Canada.<br />
#1129 HUMAN SUSCEPTIBILITY GENE CONFERS<br />
BERYLLIUM HYPERSENSITIVITY ON FVB MICE.<br />
L. M. Tarantino 1 , C. Sorrentino 1 , Y. Zhu 2 , E. M. Rubin 2 ,<br />
S. S. Tinkle 3 and T. Gordon 1 . 1 Department <strong>of</strong><br />
Environmental Medicine, NYU School <strong>of</strong> Medicine,<br />
Tuxedo, NY, 2 Department <strong>of</strong> Genome Sciences,<br />
Lawrence Berkeley National Laboratory, Berkeley, CA<br />
and 3 NIEHS, Research Triangle Park, NC.<br />
#1130 THE ROLE OF HYPOXIA INDUCIBLE FACTOR<br />
1α IN COBALT CHLORIDE INDUCED CELL<br />
DEATH IN MOUSE EMBRYONIC<br />
FIBROBLASTS. A. Vengellur 2,1 and J. LaPres 1,3,4 .<br />
1 Biochemistry and Molecular Biology, Michigan State<br />
University, East Lansing, MI, 2 Graduate <strong>Program</strong> in<br />
Genetics, Michigan State University, East Lansing, MI,<br />
3 National Food Safety and <strong>Toxicology</strong> Center, Michigan<br />
State University, East Lansing, MI and 4 Center for<br />
Integrative <strong>Toxicology</strong>, Michigan State University, East<br />
Lansing, MI.<br />
#1131 STUDIES OF MECHANISMS OF POTASSIUM<br />
DICHROMATE-INDUCED NEPHROTOXICITY<br />
IN ISOLATED RAT RENAL CORTICAL SLICES.<br />
J. chen and S. K. Chakrabarti. Department <strong>of</strong><br />
Environmental and Occupational Health, Faculty <strong>of</strong><br />
Medicine, Universite de Montreal, Montreal, QC,<br />
Canada.<br />
#1132 PROTECTIVE EFFECT OF ALPHA-<br />
TOCOPHEROL ON RENAL INJURY CAUSED BY<br />
CHROMATE EXPOSURE. L. Arreola-Mendoza 1 , J.<br />
L. Reyes 2 , M. C. Namorado 2 , D. Martin 2 and L. M. Del<br />
Razo 1 . 1 <strong>Toxicology</strong>, Cinvesta-IPN, Mexico D.F, Mexico<br />
and 2 Physiol. Biophs.& Neurosci, Cinvesta-IPN,<br />
Mexico D.F, Mexico.<br />
#1133 CHROMIUM(VI) ACTIVATES STAT3 IN<br />
BRONCHIAL EPITHELIAL CELLS. K. A. O’Hara,<br />
R. J. Vaghjiani, L. R. Klei and A. Barchowsky.<br />
Environmental and Occupational Health, Graduate<br />
School <strong>of</strong> Public Health, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA.<br />
#1134 CARCINOGENIC LEAD CHROMATE INDUCES<br />
DNA DOUBLE-STRAND BREAKS AND<br />
ACTIVATES ATM KINASE IN HUMAN LUNG<br />
CELLS. H. Xie 1,2 , S. S. Wise 1,2 , A. L. Holmes 1,2 and J.<br />
P. Wise 1,2 . 1 Wise Laboratory <strong>of</strong> Environmental and<br />
Genetic <strong>Toxicology</strong>, University <strong>of</strong> Southern Maine,<br />
Portland, ME and 2 Maine Center for <strong>Toxicology</strong> and<br />
Environmental Health, University <strong>of</strong> Southern Maine,<br />
Portland, ME.<br />
#1135 REPAIR OF CHROMATE-INDUCED<br />
CHROMOSOME DAMAGE IS MEDIATED BY<br />
XRCC1. E. G. Duzevik 1,2 , S. S. Wise 1,2 , R. C.<br />
Munroe 1,2 and J. P. Wise 1,2 . 1 Maine Center for<br />
<strong>Toxicology</strong> and Environmental Health, University <strong>of</strong><br />
Southern Maine, Portland, ME and 2 Wise Laboratory <strong>of</strong><br />
Environmental and Genetic <strong>Toxicology</strong>, University <strong>of</strong><br />
Southern Maine, Portland, ME.<br />
136<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1136 IMPAIRMENT OF CHROMIUM-DNA ADDUCT<br />
FORMATION BY HYPOXIA. T. J. O’Brien 1,2 , H. G.<br />
Mandel 1,2 , K. D. Sugden 4 , A. Komarov 3 and S. R.<br />
Patierno 1,2 . 1 Pharmacology and Physiology, The George<br />
Washington University Med. Ctr., Washington, DC,<br />
2 The GW Cancer Institute, The George Washington<br />
University Med. Ctr., Washington, DC, 3 Biochemistry<br />
and Molecular Biology, The George Washington<br />
University Med. Ctr., Washington, DC and 4 Chemistry,<br />
University <strong>of</strong> Montana, Missoula, MT.<br />
#1137 ACUTE INHALATION TOXICITY OF<br />
TRIMETHYL GALLIUM IN RATS. G. R.<br />
Kiplinger 1 , G. P. Rosini 2 , S. V. Kala 3 , E. C. Bisinger,<br />
Jr. 4 and J. L. Orr 4 . 1 WIL Research Laboratories, Inc.,<br />
Ashland, OH, 2 Akzo Nobel Polymer Chemicals LLC,<br />
Chicago, IL, 3 Baylor School <strong>of</strong> Medicine, Houston, TX<br />
and 4 Akzo Nobel Chemicals Inc., Chicago, IL.<br />
#1138 OAT1 TRANSPORTS N-ACETYLCYSTEINE<br />
(NAC)-S CONJUGATES OF BOTH<br />
METHYLMERCURY AND INORGANIC<br />
MERCURY IN MDCK CELLS. S. Ahmad and R. K.<br />
Zalups. Basic Sciences, School <strong>of</strong> Medicine, Mercer<br />
University, Macon, GA.<br />
#1139 MERCURIC CHLORIDE ALTERS BAX-BCL2<br />
RATIO IN LEYDIG CELLS TOWARD<br />
APOPTOTIC PATHWAY. M. Mansour, J. Persaud, R.<br />
Ricks, K. Ali, H. El-kholy and A. Atkinson. College <strong>of</strong><br />
Veterinary Medicine, Nursing & Allied Health,<br />
Tuskegee University, Tuskegee, AL. Sponsor: R. Dalvi.<br />
#1140 EFFECTS OF SUBCHRONIC EXPOSURE TO<br />
MERCURIC CHLORIDE ON RAT FERTILITY<br />
AND REPRODUCTIVE PERFORMANCE: A<br />
CROSSOVER MATING TRIAL STUDY. K. A. Ali,<br />
A. Atkinson, H. EL-Kholy, M. Mansour, C. Harris, D.<br />
Chaney and M. Campbell. College <strong>of</strong> Veterinary<br />
Medicine, Nursing & Allied Health, Tuskegee<br />
University, Tuskegee, AL. Sponsor: R. Dalvi.<br />
#1141 MN INDUCED PULMONARY VEGF-<br />
EXPRESSION IN VIVO: A POTENTIAL<br />
MECHANISM OF PULMONARY TOXICITY. K. K.<br />
Divine, M. M. Falgout, T. H. March and S. Bredow.<br />
Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
#1142 A POTENTIAL MECHANISM FOR PULMONARY<br />
MANGANESE-TOXICITY: MANGANESE<br />
INDUCES PULMONARY VEGF EXPRESSION IN<br />
VITRO. S. Bredow, M. M. Falgout and K. K. Divine.<br />
Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
#1143 THE DISTURBANCE OF CELLULAR IRON<br />
REGULATION BY SOLUBLE NICKEL<br />
EXPOSURE AND ITS POSSIBLE MECHANISMS.<br />
H. Chen, T. Davidson and M. Costa. Environmental<br />
Medicine, New York University, Tuxedo, NY.<br />
#1144 SOLUBLE NICKEL ALTERS IRON<br />
HOMEOSTASIS. T. L. Davidson 1 , H. Chen 1 , M. D.<br />
Garrick 2 , S. Singleton 2 and M. Costa 1 . 1 Department <strong>of</strong><br />
Env. Med., New York University, Tuxedo, NY and<br />
2 Department <strong>of</strong> Biochemistry, SUNY Buffalo, Buffalo,<br />
NY.<br />
#1145 CHRONIC EXPOSURE TO LEAD IONS FROM<br />
LEAD CHROMATE INTERFERES WITH<br />
NORMAL MITOTIC PROGRESSION. A. L.<br />
Holmes 1,2 , S. J. Sandwick 1,2 , S. S. Wise 1,2 , N. Gordon 3,2<br />
and J. P. Wise 1,2 . 1 Wise Laboratory <strong>of</strong> Environmental<br />
and Genetic <strong>Toxicology</strong>, University <strong>of</strong> Southern Maine,<br />
Portland, ME, 2 Maine Center for <strong>Toxicology</strong> and<br />
Environmental Health, University <strong>of</strong> Southern Maine,<br />
Portland, ME and 3 Department <strong>of</strong> Chemistry, University<br />
<strong>of</strong> Southern Maine, Portland, ME.<br />
#1146 MICRONUCLEUS FREQUENCY IN BLOOD<br />
LYMPHOCYTES FROM CHILDREN<br />
ENVIRONMENTALLY EXPOSED TO LEAD. M.<br />
Moreno 1,2 , F. Rios 1 , M. Sordo 3 , E. Vera 2 , L. C. Acosta-<br />
Saavedra 2 , M. E. Cebrian 2 , E. S. Calderon-Aranda 2 and<br />
P. Ostrosky 3 . 1 Facultad de Ciencias Quimico Biologicas,<br />
UAG, Chilpancingo, Gro., Mexico, 2 Toxicologia,<br />
Cinvestav, Mexico, DF, Mexico and 3 Instituto de<br />
Investigaciones Biomedicas, UNAM, Mexico, DF,<br />
Mexico.<br />
#1147 SPERM NUCLEUS UPTAKES LEAD FROM<br />
TESTIS AND EPIDIDYMIS, ALTERING SPERM<br />
CHROMATIN CONDENSATION. I. Hernandez-<br />
Ochoa 1 , M. Solis-Heredia 1 , V. Rosales-Garcia 2 and B.<br />
Quintanilla-Vega 1 . 1 <strong>Toxicology</strong> Section, CINVESTAV-<br />
IPN, Mexico City, D.F., Mexico and 2 Central<br />
Laboratory, CINVESTAV-IPN, Mexico City, D.F.,<br />
Mexico.<br />
#1148 ASSOCIATIONS AMONG URIC ACID, LEAD<br />
BIOMARKERS, RENAL FUNCTION AND<br />
GENETIC POLYMORPHISMS IN KOREAN<br />
LEAD WORKERS. V. M. Weaver 1 , B. S. Schwartz 1 ,<br />
B. G. Jaar 1 , A. C. Todd 2 , K. Ahn 3 , K. T. Kelsey 4 , E. K.<br />
Silbergeld 1 , J. Wen 1 and B. Lee 3 . 1 Johns Hopkins<br />
University BSPH, Baltimore, MD, 2 Mount Sinai School<br />
<strong>of</strong> Medicine, New York, 3 SoonChunHyang University,<br />
Asan, South Korea and 4 Harvard School <strong>of</strong> Public<br />
Health, Boston, MA.<br />
#1149 PBPK MODELING OF THE EFFECT OF<br />
MICROGRAVITY ON THE RELEASE OF LEAD<br />
FROM BONE INTO BLOOD. H. D. Garcia 1 and S.<br />
Hays 2 . 1 Life Sciences Systems and Services, Wyle<br />
Laboratories, Houston, TX and 2 Intertox, Lyons, CO.<br />
Sponsor: C. Lam.<br />
#1150 PHARMACOKINETICS OF LEAD (PB) IN<br />
SALIVA OF RATS FOLLOWING AN ACUTE<br />
ORAL EXPOSURE. K. K. Weitz, D. A. Moore, R. A.<br />
Gies, H. Wu and C. Timchalk. Pacific Northwest<br />
National Laboratory, Richland, WA.<br />
#1151 LEAD DISTRIBUTION FOLLOWING<br />
RESPIRATORY EXPOSURE TO LEAD-<br />
CONTAINING MATERIALS IN SPRAGUE-<br />
DAWLEY RATS. G. M. Fent 1 , T. J. Evans 1 , D.<br />
Bannon 2 , M. Dunsmore 1 and S. W. Casteel 1 . 1 Veterinary<br />
Pathobiology, University <strong>of</strong> Missouri, Columbia, MO<br />
and 2 US Army center for Health Promotion and<br />
Preventitive Medicine, Aberdeen Proving Ground, MD.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 137
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1152 ROLE OF PLASMA GLUTATHIONE IN HEPATIC<br />
TOXICITY CAUSED BY VANADIUM<br />
COMPOUNDS IN MICE. T. Hasegawa 1 , M. Satoh 2<br />
and Y. Seko 1 . 1 Environmental Biochemistry, Yamanashi<br />
Institute <strong>of</strong> Environmental Sciences, Fujiyoshida,<br />
Yamanashi, Japan and 2 Department <strong>of</strong> Hygienics, Gifu<br />
Pharmaceutical University, Gifu, Japan.<br />
#1153 SPLEEN REPERCUSSIONS AFTER CHRONIC<br />
INHALATION OF VANADIUM PENTOXIDE<br />
(V2O5) EVALUATED IN MICE. T. I. FORTOUL 1 , G.<br />
Pinon-Zarate 1 , A. Gonzalez-Villalva 1 , V. Rodriguez-<br />
Lara 1 , M. Rojas-Lemus 1 , P. Mussali-Galante 1 , M. Avila-<br />
Casado 1 , V. Delgado 1 , F. Pasos 1 , B. Chavez 1 and M.<br />
AVILA-COSTA 2 . 1 Biologia Celular Y Tisular, Facultad<br />
de Medicina, UNAM, Mexico, Mexico and<br />
2 Neuromorfologia, Fes Iztacala, UNAM, Mexico,<br />
Mexico.<br />
#1154 ROLE OF OXIDATIVE STRESS IN THE<br />
MODULATION OF AHR-REGULATED GENE<br />
EXPRESSION BY HEAVY METALS. R. H. Elbekai<br />
and A. O. El-Kadi. University <strong>of</strong> Alberta, Edmonton,<br />
AB, Canada.<br />
#1155 INTEGRATIVE ANALYSIS OF GENOME-WIDE<br />
GENE EXPRESSION AND PATHWAY MAPPING<br />
IN MOUSE EMBRYONIC FIBROBLAST (MEF)<br />
EXPOSED TO CADMIUM, ARSENIC AND<br />
METHYLMERCURY: INDUCTION OF<br />
OXIDATIVE STRESS, DISRUPTION OF<br />
UBIQUITIN-PROTEASOME SYSTEM AND CELL<br />
CYCLE REGULATION. X. Yu, J. S. Sidhu, J. F.<br />
Robinson, S. Hong and E. M. Faustman. Environmental<br />
Health, IRARC, UW, Seattle, WA.<br />
#1156 EFFECT OF COMBINED LEAD, CADMIUM AND<br />
ARSENIC EXPOSURE ON THE EXPRESSION OF<br />
CELLULAR PROTECTIVE FACTORS IN RAT<br />
KIDNEYS AT LOEL DOSE LEVELS. G. Wang, X.<br />
Chen, M. M. Lipsky, M. H. Whittaker and B. A. Fowler.<br />
<strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong> Maryland,<br />
Baltimore, MD.<br />
#1157 COMPARISON OF METALS IN CYTOTOXICITY,<br />
FREE RADICAL GENERATION, AND HEAT<br />
SHOCK PROTEIN EXPRESSION IN A HUMAN<br />
BRONCHIAL EPITHELIAL CELL LINE, BEAS-<br />
2B. S. Han 1,2 and V. Vallyathan 1 . 1 Pathology and<br />
Physiology Research Branch, National Institute for<br />
Occupational Safety and Health, Morgantown, WV and<br />
2 Genetics and Developmental Biology, West Virginia<br />
University, Morgantown, WV.<br />
#1158 METAL-INDUCED OXIDATION OF<br />
THIOREDOXIN-1 AND THIOREDOXIN-2. J. M.<br />
Hansen and D. P. Jones. Medicine, Emory University,<br />
Atlanta, GA.<br />
#1159 INDUCTION OF OXIDATIVE STRESS IN<br />
RESPONSE TO INGESTION OF LEAD,<br />
CADMIUM AND ARSENIC MIXTURES. M. H.<br />
Whittaker, B. A. Fowler, G. Wang, C. Xue-Qing and M.<br />
Lipsky. <strong>Toxicology</strong> <strong>Program</strong>, The University <strong>of</strong><br />
Maryland, Baltimore, Baltimore, MD.<br />
#1160 CHANGING METAL ACCUMULATION IN NEW<br />
ORLEANS: DIFFERENCES BETWEEN SURVEY<br />
I (1992) AND SURVEY II (2000). H. W. Mielke 1 , E.<br />
Powell 1 , C. Gonzales 1 and P. Mielke (Emeritus) 2 .<br />
1 College <strong>of</strong> Pharmacy, Xavier University, New Orleans,<br />
LA and 2 Statistics, Colorado State University, Fort<br />
Collins, CO.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: GENE REGULATION: METALS<br />
Chairperson(s): Jay Gandolfi, University <strong>of</strong> Arizona, Tucson, AZ.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1161 TOXICOGENOMICAL STUDY ON HUMAN<br />
BLADDER EPITHELIUM EXPOSED TO<br />
ARSENIC. X. Zheng 1 , T. G. Bredfeldt 1 , G. S. Watts 2<br />
and A. Gandolfi 1 . 1 Pharmacology/<strong>Toxicology</strong>, College<br />
<strong>of</strong> Pharmacy, University <strong>of</strong> Arizona, Tucson, AZ and<br />
2 Arizona Cancer Center, University <strong>of</strong> Arizona, Tucson,<br />
AZ.<br />
#1162 DIFFERENTIAL EFFECTS OF CHRONIC LOW<br />
LEVEL ARSENIC EXPOSURES ON<br />
TRANSCRIPTION FACTOR BINDING IN<br />
CARDIOVASCULAR TISSUES. L. R. Klei 1,2 , M. A.<br />
Ihnat 3 , N. V. Soucy 2 , A. A. Nemec 1 and A.<br />
Barchowsky 1,2 . 1 Environmental and Occupational<br />
Health, University <strong>of</strong> Pittsburgh Graduate School <strong>of</strong><br />
Public Health, Pittsburgh, PA, 2 Pharmacology and<br />
<strong>Toxicology</strong>, Dartmouth Medical School, Hanover, NH<br />
and 3 Cell Biology, University <strong>of</strong> Oklahoma Health<br />
Sciences Center, Oklahoma City, OK.<br />
#1163 EUKARYOTIC TRANSLATION INITIATION<br />
FACTOR 4E IS A CELLULAR TARGET FOR<br />
ARSENIC BUT NOT CHROMIUM TOXICITY. P.<br />
Joseph and S. Othumpangat. NIOSH, Morgantown,<br />
WV.<br />
#1164 EFFECT OF ARSENITE ON PU.1, C/EBPS, AND<br />
NFKB ACTIVATION IN U937 PROMONOCYTIC<br />
LEUKEMIA CELLS. M. Yamamoto 1 , S. Hirano 1 , C.<br />
R. Jefcoate 2 and F. Matsumura 3 . 1 Environmental Health<br />
Sciences Division, National Institute for Environmental<br />
Studies, Tsukuba, Ibaraki, Japan, 2 Pharmacology,<br />
University <strong>of</strong> Wisconsin-Madison, Madison, WI and<br />
3 Environmental <strong>Toxicology</strong>, University <strong>of</strong> California-<br />
Davis, Davis, CA.<br />
#1165 IDENTIFICATION OF MOUSE SLC39A8 AS THE<br />
TRANSPORTER RESPONSIBLE FOR<br />
CADMIUM-INDUCED TOXICITY IN THE<br />
TESTIS. L. He 1 , T. P. Dalton 1 , B. Wang 1 , M. L. Miller 1 ,<br />
L. Jin 1 , K. F. Stringer 2 , X. Chang 1 , C. S. Baxter 1 and D.<br />
W. Nebert 1 . 1 Department <strong>of</strong> Environmental Health, and<br />
the Center for Environmental Genetics (CEG),<br />
University <strong>of</strong> Cincinnati, Cincinnati, OH and<br />
2 Department <strong>of</strong> Pathology, Cincinnati Children’s<br />
Hospital Medical Center, Cincinnati, OH.<br />
138<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1166 ROLE OF EUKARYOTIC TRANSLATION<br />
INITIATION FACTOR 4E (EIF4E) IN CADMIUM-<br />
INDUCED CYTOTOXICITY AND CELL DEATH.<br />
S. Othumpangat and P. Joseph. <strong>Toxicology</strong> and<br />
Molecular Biology Branch, NIOSH, Morgantown, WV.<br />
#1167 MECHANISMS OF ARSENITE-STIMULATED<br />
HEMEOXYGENASE-1 UPREGULATION IN<br />
HUMAN KERATINOCYTES. K. L. Cooper and L. G.<br />
Hudson. College <strong>of</strong> Pharmacy, University <strong>of</strong> NM,<br />
Albuquerque, NM.<br />
#1168 MERCURY, CADMIUM, ZINC, AND ARSENITE<br />
INHIBIT PAX3 DNA BINDING VIA THE PAIRED<br />
DOMAIN. F. A. Leal 1 , A. F. Machado 2 , M. D. Collins 1<br />
and J. M. Fukuto 1 . 1 Molecular <strong>Toxicology</strong> IDP,<br />
University <strong>of</strong> California, Los Angeles, CA and<br />
2 Department <strong>of</strong> Environmental and Occupational<br />
Health, California State University, Northridge, CA.<br />
Sponsor: O. Hankinson.<br />
#1169 NFκB MEDIATES ZINC-INDUCED COX-2<br />
EXPRESSION IN HUMAN BRONCHIAL<br />
EPITHELIAL CELLS. W. wu 1 . 1 Center for<br />
Environmental Medicine, University <strong>of</strong> North Carolina,<br />
Chapel Hill, NC and 2 Human Studies Division, U.S.<br />
EPA, Research Triangle Park, NC. Sponsor: M.<br />
Madden.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: PHARMACEUTICALS-METHODS OF<br />
EVALUATION<br />
Chairperson(s): Patrick Hayden, MatTek Corporation, Ashland, MA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1170 COMPARISON OF BCNU AND SARCNU<br />
TOXICITY IN LONG-TERM CULTURES OF<br />
PRECISION-CUT LUNG SLICES. C. A. Tyson, K.<br />
Amin, C. Ip and H. P. Behrsing. <strong>Toxicology</strong> Laboratory,<br />
SRI International, Menlo Park, CA.<br />
#1171 A HIGH-THROUGHPUT IN VITRO MODEL OF<br />
HUMAN TRACHEAL/BRONCHIAL<br />
EPITHELIUM (EPIAIRWAY) FOR PRECLINICAL<br />
SAFETY AND EFFICACY TESTING OF<br />
PHARMACEUTICALS. P. J. Hayden, G. R. Jackson,<br />
J. Kubilus, J. E. Sheasgreen and M. Klausner. MatTek<br />
Corp., Ashland, MA.<br />
#1172 VASCULAR PERMEABILITY IN THE RAT. S.<br />
Rowton and P. Robinson. Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom. Sponsor: D. Everett.<br />
#1173 REDUCED STRESS IN GROUP HOUSED NON-<br />
HUMAN PRIMATES. S. Grainger 1 , J. Hedley 1 and M.<br />
Nieh<strong>of</strong> 2 . 1 Covance Laboratories Ltd., Harrogate, United<br />
Kingdom and 2 Covance Laboratories GmbH, Munster,<br />
Germany. Sponsor: D. Everett.<br />
#1174 PREDICTING ANTIEPILEPTIC DRUG<br />
TOXICITY USING HEPATIC PROTEIN<br />
COVALENT BINDING AND GENE EXPRESSION<br />
POTENTIAL. A. M. Leone 1 , L. M. Kao 1 , M.<br />
McMillian 1 , A. Y. Nie 1 , J. B. Parker 1 , M. F. Kelley 1 , M.<br />
D. Johnson 1 , E. Usuki 2 , A. Parkinson 2 and P. Lord 1 .<br />
1 Mechanistic <strong>Toxicology</strong>, Johnson & Johnson<br />
Pharmaceutical Research & Development, L.L.C.,<br />
Raritan, NJ and 2 XenoTech LLC, Lenexa, KS.<br />
#1175 IN VIVO AND IN VITRO NON-CLINICAL DRUG<br />
SAFETY ASSESSMENT: A KEY PARTNER FOR<br />
ANTICANCER DRUG DEVELOPMENT. N. Lhote 1 ,<br />
Y. Sibiril 3 , D. Bazot 1 , A. Beamonte 1 , J. Delongeas 1 , D.<br />
Parent-Massin 3 and N. Claude 2 . 1 Servier Group, Gidy,<br />
France, 2 Servier Group, Courbevoie, France and 3 LTA<br />
EA3880, UBO Brest, France.<br />
#1176 PHARMACOKINETICS AND ENHANCED ORAL<br />
BIOAVAILABILITY OF NANOSTRUCTURED<br />
DRUG CRYSTALS: COMPARISON OF<br />
PARTICLE ENGINEERING TECHNOLOGIES<br />
FOR DANAZOL, KETOCONAZOLE AND<br />
NAPROXEN IN BEAGLE DOGS. G. G.<br />
Kupperblatt 2 , S. A. Saghir 1 , D. A. Markham 1 , T. L.<br />
Rogers 2 , C. J. Tucker 3 , J. E. Hitt 2 and E. J. Elder 2 .<br />
1 <strong>Toxicology</strong> & Environmental Research & Consulting,<br />
The Dow Chemical Company, Midland, MI,<br />
2 Dowpharma, The Dow Chemical Company, Midland,<br />
MI and 3 Corporate R&D, The Dow Chemical Company,<br />
Midland, MI.<br />
#1177 REDUCTION AND REFINEMENT IN<br />
RADIOLABELLED PRIMATE METABOLISM<br />
STUDIES. J. Kelly, J. Hedley and R. Allen. Covance<br />
Laboratories Ltd., Harrogate, United Kingdom.<br />
Sponsor: D. Everett.<br />
#1178 ADJUVANT ARTHRITIS IN THE MALE LEWIS<br />
RAT. S. Rowton and P. Robinson. Covance<br />
Laboratories Ltd., Harrogate, United Kingdom.<br />
Sponsor: D. Everett.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SAFETY EVALUATION-NON<br />
PHARMACEUTICAL<br />
Chairperson(s): Eugenia Theophilus, R.J. Reynolds Tobacco Company,<br />
Winston Salem, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1179 EVALUATION OF GENOTOXICITY AND<br />
SENSITIZATION POTENTIAL OF PEPTIDE<br />
COUPLING REAGENTS. D. A. Seid 1 , S. S. Kim 2 and<br />
S. Kim 1 . 1 Applied Biosystems, Foster City, CA and<br />
2 University <strong>of</strong> California, Berkeley, CA.<br />
#1180 COMPARISON OF PHOTOTOXICITY TESTING<br />
METHODS USED TO SCREEN LEAD<br />
COMPOUNDS L. LEE, G. STEVENS, AND B.<br />
JESSEN. PFIZER GLOBAL R&D. L. Lee. Pfizer<br />
Global R&D, San Diego, CA. Sponsor: G. Stevens.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 139
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1181 SUBCHRONIC TOXICITY STUDY OF<br />
HEXACHLOROBENZENE (HCB) IN FEMALE<br />
HARLAN SPRAGUE-DAWLEY RATS. J. D.<br />
Johnson 1 , D. Vasconcelos 1 , M. Ryan 1 , A. Fuciarelli 2 , S.<br />
Graves 1 , M. Hejtmancik 1 , A. Braen 3 , M. Vallant 4 , H.<br />
Toyoshiba 4 , R. Chhabra 4 , N. Walker 4 and M. Hooth 4 .<br />
1 Health and Life Sciences, Battelle, Columbus, OH,<br />
2 Colorado State University, Fort Collins, CO,<br />
3 4 H<strong>of</strong>fmann-La Roche, Nutley, NJ and NIEHS, NIH,<br />
Research Triangle Park, NC.<br />
#1182 SUBCHRONIC TOXICITY OF ALPHA-METHYL-<br />
1, 3-BENZODIOXOLE-5-PROPIONALDEHYDE<br />
IN RATS. A. Lapczynski, D. Isola and A. Api. Research<br />
Institute for Fragrance Material, Inc., Woodcliff Lake,<br />
NJ.<br />
#1183 SUBCHRONIC TOXICITY OF ACETYL<br />
CEDRENE IN RATS. C. Letizia, D. A. Isola and A.<br />
Api. Research Institute for Fragrance Materials, Inc.,<br />
Woodcliff Lake, NJ.<br />
#1184 CNS AND CARDIORESPIRATORY EFFECTS OF<br />
TWO NOVEL BISPYRIDINIUM OXIMES (ICD-39<br />
AND ICD-585). F. T. Chang, D. Spriggs and S. DeBus.<br />
Applied Pharmacology, USAMRICD, APG-EA, MD.<br />
Sponsor: A. Sciuto.<br />
#1185 TOXICOLOGICAL EVALUATION OF<br />
CIGARETTES WITH TWO BANDED<br />
CIGARETTE PAPER TECHNOLOGIES. E. H.<br />
Theophilus, D. R. Meckley, K. W. Shreve, P. H. Ayres,<br />
B. R. Bombick, M. F. Borgerding, C. D. Garner, D. H.<br />
Pence and J. E. Swauger. Research & Development, R.<br />
J. Reynolds Tobacco Company, Winston-Salem, NC.<br />
#1186 TOXICOLOGICAL EVALUATION OF A<br />
CIGARETTE PAPER WITH REDUCED<br />
IGNITION PROPENSITY: IN VITRO AND IN<br />
VIVO TESTS. M. Misra 1 , R. D. Leverette 1 , J. T.<br />
Hamm 1 , M. B. Bennett 1 , J. D. Heck 1 , R. Morrissey 2 and<br />
N. Rajendran 3 . 1 Lorillard Tobacco Company,<br />
Greensboro, NC, 2 PAI, Chicago, IL and 3 IIT Research<br />
Institute, Chicago, IL.<br />
#1187 TOXICOLOGICAL EVALUATION OF<br />
DIAMMONIUM PHOSPHATE (DAP) AND UREA<br />
AS INGREDIENTS ADDED TO CIGARETTE<br />
TOBACCO. M. S. Stavanja, P. H. Ayres, G. M. Curtin,<br />
B. R. Bombick, M. F. Borgerding, C. D. Garner, D. H.<br />
Pence and J. E. Swauger. R.J. Reynolds Tobacco<br />
Company, Winston-Salem, NC.<br />
#1188 IN VITRO TOXICITY EVALUATION OF<br />
TOOTHPASTES USING RECONSTRUCTED<br />
HUMAN ORAL AND GINGIVAL MUCOSA<br />
MODELS. B. De Wever 1 , B. Vande Vannet 2 , P.<br />
Bottenberg 2 and M. Cappadoro 1 . 1 SkinEthic<br />
Laboratories, Nice, France and 2 Free University <strong>of</strong><br />
Brussels, Brussels, Belgium.<br />
#1189 IN VITRO SAFETY EVALUTION STUDIES OF<br />
LUTEIN AND ZEAXANTHIN. X. Chen 1 , B. A.<br />
Fowler 2 and F. Khachik 3 . 1 <strong>Program</strong> in <strong>Toxicology</strong>,<br />
Department <strong>of</strong> Epidemiology & Preventive Medicine,<br />
University <strong>of</strong> Maryland, Baltimore, Baltimore, MD,<br />
2 Division <strong>of</strong> <strong>Toxicology</strong>, Agency for toxic Substances<br />
and Disease Registry, Atlanta, GA and 3 Chemistry and<br />
Biochemistry, University <strong>of</strong> Maryland, College Park,<br />
MD.<br />
#1190 AEROSOL CHARACTERIZATION FOR<br />
CONSUMER LAUNDRY ENZYME-CONTAINING<br />
STAIN REMOVERS. F. Ayala-Fierro 1 , D. P. Davis 1 , J.<br />
Billman 2 , C. Jeng 3 , R. E. Rogers 3 and A. Lefebvre 3 .<br />
1 Clinical Studies and <strong>Toxicology</strong>, The Dial Corporation,<br />
Scottsdale, AZ, 2 Research and Development, The Dial<br />
Corporation, Scottsdale, AZ and 3 Toxcon HSRC,<br />
Edmonton, AB, Canada.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: HYPERSENSITIVITY II<br />
Chairperson(s): Frank Gerberick, Procter & Gamble, Miami Valley<br />
Laboratories, Cincinnati, OH.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1191 ENHANCING EFFECT OF CHLORINATED<br />
ORGANIC SOLVENTS ON INFLAMMATORY<br />
MEDIATOR PRODUCTION. M. Seo, M. Satoh and<br />
H. Nagase. DEPARTMENT OF HYGIENICS, GIFU<br />
PHARMACEUTICAL UNIVERSITY, GIFU, Japan.<br />
#1192 RELATIONSHIP BETWEEN CD86/CD54<br />
EXPRESSION AND CELL VIABILITY IN IN<br />
VITRO SKIN SENSITIZATION TEST OF WATER-<br />
SOLUBLE CHEMICALS USING THP-1 CELLS. T.<br />
Ashikaga 1 , H. Sakaguchi 2 , K. Yoneyama 1 , S. Sono 1 , M.<br />
Miyazawa 2 , Y. Yoshida 2 , Y. Ito 2 , H. Suzuki 2 , H. Itagaki 1<br />
and H. Toyoda 1 . 1 Shiseido Co., Ltd.,, Kanagawa, Japan<br />
and 2 Kao Corporation, Tochiga, Japan.<br />
#1193 THE RELASHIONSHIP BETWEEN CD86/CD54<br />
EXPRESSION AND THP-1 CELL VIABILITY IN<br />
AN IN VITRO SKIN SENSITIZATION TEST FOR<br />
WATER-INSOLUBLE CHEMICALS. H.<br />
SAKAGUCHI 1 , T. ASHIKAGA 2 , M. MIYAZAWA 1 , Y.<br />
YOSHIDA 1 , Y. ITO 1 , K. YONEYAMA 2 , S. SONO 2 , H.<br />
ITAGAKI 2 , H. TOYODA 2 and H. SUZUKI 1 . 1 Kao<br />
Corporation, Tochigi, Japan and 2 Shiseido Co., Ltd.,,<br />
Kanagawa, Japan.<br />
#1194 PHENOTYPIC ALTERATIONS AND CYTOKINE<br />
PRODUCTION IN THP-1 CELLS IN RESPONSE<br />
TO ALLERGENS. M. MIYAZAWA, Y. ITO, Y.<br />
YOSHIDA, H. SAKAGUCHI and H. SUZUKI. Kao<br />
Corporation, TOCHIGI, Japan. Sponsor: J. AVALOS.<br />
#1195 EVALUATION OF CYTOKINES RELEASE FROM<br />
THP-1 CELLS AS PREDICTIVE MARKERS OF<br />
CONTACT SENSITIZATION. R. Slim, R. Petty, M.<br />
S. LaGattuta and J. R. Piccotti. Worldwide Safety<br />
Sciences, Pfizer Global Research & Development, Ann<br />
Arbor, MI.<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1196 USE OF HISTORICAL LOCAL LYMPH NODE<br />
DATA IN THE DEVELOPMENT OF<br />
ALTERNATIVE TEST METHODS FOR SKIN<br />
SENSITIZATION. C. Ryan 1 , P. Kern 2 , D. Basketter 3 ,<br />
G. Patlewicz 3 , R. Dearman 4 , I. Kimber 4 and F.<br />
Gerberick 1 . 1 Procter & Gamble Company, Cincinnati,<br />
OH, 2 Procter & Gamble Company, Brussels, Belgium,<br />
3 SEAC, Unilever, Sharnbrook, United Kingdom and<br />
4 Central <strong>Toxicology</strong> Laboratory, Syngenta,<br />
Macclesfield, United Kingdom.<br />
#1197 DEVELOPMENT OF A PEPTIDE REACTIVITY<br />
MODEL FOR SCREENING THE SKIN<br />
SENSITIZATION POTENTIAL OF CONTACT<br />
ALLERGENS. J. D. Vassallo 1 , J. G. Chaney 1 , R. E.<br />
Bailey 1 , S. W. Morrall 1 , B. B. Price 1 , J. Lepoittevin 2<br />
and F. G. Gerberick 1 . 1 Central Product Safety, Procter<br />
& Gamble, Cincinnati, OH and 2 Laboratorie de<br />
Dermatochimie, Universite Louis Pasteur, Strasburg,<br />
France.<br />
#1198 IDENTIFICATION OF POTENTIAL MARKERS<br />
FOR THE PREDICTION OF SKIN<br />
SENSITIZATION: REAL-TIME PCR ANALYSIS<br />
OF ALLERGEN-TREATED DENDRITIC CELLS.<br />
L. Gildea 1 , C. A. Ryan 1 , B. C. Hulette 1 , L. Foertsch 1 , R.<br />
J. Dearman 2 , I. Kimber 2 and F. Gerberick 1 . 1 Procter &<br />
Gamble Company, Cincinnati, OH and 2 Syngenta<br />
Central <strong>Toxicology</strong> Laboratory, Macclesfield, United<br />
Kingdom.<br />
#1199 EFFECTS OF LIPOPHILICITY AND VISCOSITY<br />
OF SOLVENTS ON DPM/LN BACKGROUND<br />
LEVEL IN MURINE LOCAL LYMPH NODE<br />
ASSAY (LLNA). W. Wang-Fan, L. G. Ullmann and G.<br />
Arcelin. <strong>Toxicology</strong>, RCC Ltd., Fuellinsdorf,<br />
Switzerland. Sponsor: K. Sachsse.<br />
#1200 INFLUENCE OF AGEING ON LOCAL LYMPH<br />
NODE ASSAY RESPONSES TO HEXYL<br />
CINNAMIC ALDEHYDE. C. Betts, A. Banyard, L.<br />
Beresford, R. J. Dearman and I. Kimber. Syngenta<br />
CTL, Macclesfield, Cheshire, United Kingdom.<br />
#1201 CORRELATION OF LLNA AND HUMAN SKIN<br />
SENSITISATION THRESHOLDS. D. A. Basketter 1 ,<br />
C. Clapp 1 , B. Safford 1 , D. Jefferies 1 , I. Kimber 2 , R.<br />
Dearman 2 , C. A. Ryan 3 and F. Gerberick 3 . 1 SEAC,<br />
Unilever, Sharnbrook, United Kingdom, 2 Syngenta<br />
CTL, Macclesfield, United Kingdom and 3 Procter &<br />
Gamble, Cincinnati, OH.<br />
#1202 POTENCEY ESTIMATIONS FOR SEVERAL<br />
FRAGRANCE MATERIALS IN THE LOCAL<br />
LYMPH NODE ASSAY AND THEIR<br />
CORRELATION TO HUMAN STUDIES. J. Lalko<br />
and A. Api. Research Institute for Fragrance Materials,<br />
Inc., Woodcliff Lake, NJ.<br />
#1203 ASSESSMENT OF THE LOCAL LYMPH NODE<br />
ASSAY USING A MODIFIED LOATS<br />
AUTOMATED MICRONUCLEUS ASSAY<br />
SYSTEM. J. Kerzee, Y. Xu and J. W. Parton.<br />
MicaGenix, Inc., Greenfield, IN.<br />
#1204 CYTOKINE EXPRESSION PROFILES OF CD4<br />
AND CD8 CELLS FROM PEANUT ALLERGEN-<br />
PRIMED MICE. P. Wachholz, R. J. Dearman and I.<br />
Kimber. Immunology, Syngenta Central <strong>Toxicology</strong><br />
Laboratory, Macclesfield, United Kingdom.<br />
#1205 ORAL AND SUBCUTANEOUS EXPOSURE TO<br />
PURIFIED PEANUT ALLERGENS AND PEANUT<br />
EXTRACT: THE FOOD MATRIX EFFECT. F. van<br />
Wijk 1,2 , R. Pieters 1 , S. Nierkens 1 , S. Koppelman 2 and<br />
L. Knippels 2 . 1 Immunotoxicology, IRAS, Utrecht,<br />
Netherlands and 2 TNO, Zeist, Netherlands.<br />
#1206 INFLUENCE OF BACTERIAL ENDOTOXIN ON<br />
IGE ANTIBODY RESPONSES PROVOKED IN<br />
MICE BY PROTEIN ALLERGENS. R. J. Dearman 1 ,<br />
D. Fox 2 , S. Attenborough 2 and I. Kimber 1 . 1 Syngenta<br />
CTL, Macclesfield, United Kingdom and 2 Syngenta<br />
Jealotts Hill, Bracknell, United Kingdom.<br />
#1207 CYTOKINE FINGERPRINTING OF CHEMICAL<br />
ALLERGENS : COMPARISONS OF MESSAGE<br />
VERSUS PROTEIN. B. Flanagan 1 , C. J. Betts 2 , H. T.<br />
Caddick 2 , R. J. Dearman 2 and I. Kimber 2 . 1 Liverpool<br />
University, Liverpool, United Kingdom and 2 Syngenta<br />
CTL, Macclesfield, United Kingdom.<br />
#1208 IMPACT OF ROUTE AND INTENSITY OF<br />
EXPOSURE DURING SENSITIZATION IN BN<br />
RATS. J. H. Arts 1 , N. Bloksma 2,3 , A. H. Penninks 1 and<br />
F. Kuper 1 . 1 TAP, TNO Nutrition and Food Research,<br />
Zeist, Netherlands, 2 Utrecht Institute for Pharmaceutical<br />
Sciences, Utrecht, Netherlands and 3 Faculty <strong>of</strong> Biology,<br />
Utrecht University, Utrecht, Netherlands. Sponsor: V.<br />
Feron.<br />
#1209 TOPICAL EXPOSURE OF MICE TO<br />
PHTHALATE IS WITHOUT ADJUVANT EFFECT.<br />
D. Shaw, R. J. Dearman and I. Kimber. Syngenta CTL,<br />
Macclesfield, United Kingdom.<br />
#1210 AUGMENTATION OF OVALBUMIN-INDUCED<br />
IGE AND AIRWAY HYPERREACTIVITY<br />
RESPONSE BY PERFLUOROOCTANOIC ACID<br />
(PFOA). K. J. Fairley 1 , S. Kearns 1 , L. P. Myers 1 , R.<br />
Purdy 2 and B. J. Meade 1 . 1 Agriculture and<br />
Immunotoxicology Group, NIOSH, Morgantown, WV<br />
and 2 Independent Toxiologist, River Falls, WI.<br />
#1211 EVALUATION OF DERMAL SENSITIZATION TO<br />
WESTERN RED CEDAR EXTRACT AND<br />
ABIETIC ACID USING THE LOCAL LYMPH<br />
NODE ASSAY. R. A. Brundage, S. Azadi, B. J. Meade,<br />
P. D. Siegel and D. N. Weissman. HELD/ASB, NIOSH,<br />
Morgantown, WV.<br />
#1212 INDUCTION OF CONTACT SENSITIZATION BY<br />
ANNATTO EXTRACT BIXIN BUT NOT BY<br />
NORBIXIN IN FEMALE BALB/C MICE. W.<br />
Auttachoat 1 , D. R. Germolec 2 , K. L. White Jr 1 and T. L.<br />
Guo 1 . 1 Virginia Commonwealth University, Richmond,<br />
VA and 2 NIEHS, Research Triangle Park, NC.<br />
#1213 DIFFERENTIAL ALLERGIC AND<br />
NEUROTROPHIN RESPONSES TO FUNGAL<br />
COMPONENT EXTRACTS IN MICE. M. Ward 1 , N.<br />
Haykal-Coates 1 , Y. Chung 2 , L. Copeland 1 and M.<br />
Selgrade 1 . 1 NHEERL, U.S. EPA, Research Triangle<br />
Park, NC and 2 SPH, UNC, Chapel Hill, NC.<br />
TUESDAY<br />
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<strong>Program</strong> Description<br />
TUESDAY<br />
#1214 EFFECTS OF DIESEL EXHAUST ON<br />
PULMONARY RESPONSES DURING ALLERGIC<br />
SENSITIZATION TO AEROSOLIZED<br />
OVALBUMIN IN BALB/C MICE. P. Singh 1 , M. J.<br />
Daniels 1 , D. L. Andrews 1 , E. H. Boykin 1 , T. Krantz 1 , W.<br />
P. Linak 2 and I. Gilmour 1 . 1 NHEERL, U.S. EPA,<br />
Research Triangle Park, NC and 2 NRMRL, U.S. EPA,<br />
Research Triangle Park, NC.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SIGNAL TRANSDUCTION I<br />
Chairperson(s): Russell Thomas, CIIT, Research Triangle Park, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1215 GLABRIDIN INHIBITS INDUCIBLE NITRIC<br />
OXIDE SYNTHASE EXPRESSION BY<br />
BLOCKING NUCLEAR FACTOR-κB<br />
ACTIVATION IN MURINE MACROPHAGES. J.<br />
Kang, Y. Yoon, I. Cho, M. Han, C. Lee, S. Park and H.<br />
Kim. Bioevaluation Center, Korea Research Institute <strong>of</strong><br />
Bioscience and Biotechnology, Taejon, South Korea.<br />
#1216 RHOA/ROCK SIGNALING NEGATIVELY<br />
REGULATES NUCLEAR FACTOR KAPPA B (NFκB)<br />
ACTIVATION VIA MODULATION OF IκBα<br />
LEVELS IN KIDNEY EPITHELIAL CELLS. M. E.<br />
Ellis, W. W. Polk, J. V. Kushleika, P. L. Simmonds and J.<br />
S. Woods. Environmental Health, University <strong>of</strong><br />
Washington, Seattle, WA.<br />
#1217 INDUCTION OF NUCLEAR FACTOR-KB<br />
ACTIVATION THROUGH TAK1 AND NIK BY<br />
DIESEL EXHAUST PARTICLES IN L2 CELL<br />
LINES. J. Lee 2 , K. Lee 2 , Y. Lim 1 , H. Kim 3 and H.<br />
Sohn 4 . 1 Occ. & Env. Med., St. Mary’s Hospital, Seoul,<br />
South Korea, 2 Pharmacology, The Catholic. University<br />
<strong>of</strong> Korea, Seoul, South Korea, 3 Internal Med.,<br />
Youngdong Severance Hospital, Seoul, South Korea and<br />
4 Preventive Med., Inje University, Busan, South Korea.<br />
Sponsor: I. Yu.<br />
#1218 APPLICATION OF A HIGH-COVERAGE,<br />
FUNCTIONAL GENOMIC SCREEN TO DISSECT<br />
THE NFκB SIGNALING PATHWAY. T. A. Halsey, T.<br />
J. Page, L. Pluta and R. S. Thomas. CIIT Centers for<br />
Health Research, Research Triangle Park, NC.<br />
#1219 TRPV1 ANTAGONISTS INDUCE<br />
TRANSLOCATION OF INTRACELLULAR<br />
TRPV1 TO THE PLASMA MEMBRANE<br />
ENHANCING VANILLOID-INDUCED<br />
TOXICITIES. M. E. Johansen 1 , C. A. Reilly 1 , D. L.<br />
Lanza 1 , J. Lee 2 and G. S. Yost 1 . 1 Department <strong>of</strong><br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Utah, Salt<br />
Lake City, UT and 2 College <strong>of</strong> Pharmacy, Seoul<br />
National University, Shinlim-Dong, South Korea.<br />
#1220 INDUCTION OF ORGANIC ANION<br />
TRANSPORTING POLYPEPTIDE 2 EXPRESSION<br />
BY CYCLIC AMP-DEPENDENT SIGNALING<br />
PATHWAY IN MOUSE HEPA-1 CELLS. C. Chen, X.<br />
G. Cheng and C. D. Klaassen. University <strong>of</strong> Kansas<br />
Medical Center, Kansas City, KS.<br />
#1221 TOBACCO SMOKE-INDUCED EPITHELIAL<br />
CELL PROLIFERATION AND SQUAMOUS<br />
METAPLASIA IN THE LUNGS OF RATS: ROLE<br />
OF MAPK/AP-1 PATHWAY. C. Zhong, Y. Zhou and<br />
K. E. Pinkerton. CHE, University <strong>of</strong> California, Davis,<br />
CA.<br />
#1222 MAPPING GENE EXPRESSION NETWORKS:<br />
USING WHOLE GENOME EXPRESSION<br />
ANALYSIS WITH RNAI TO DEFINE THE HEAT<br />
SHOCK SIGNAL TRANSDUCTION CASCADE. T.<br />
Page, T. Halsey, L. Pluta and R. S. Thomas. CIIT,<br />
Research Triangle Park, NC.<br />
#1223 IDENTIFICATION OF SIGNALING PATHWAYS<br />
ACTIVATING REACTIVE GLIOSIS IN<br />
MULTIPLE MODELS OF BRAIN INJURY: A<br />
GENOMIC, PROTEOMIC AND PROTEIN<br />
PHOSPHORYLATION ANALYSIS. K. Sriram and J.<br />
P. O’Callaghan. Centers for Disease Control &<br />
Prevention (CDC)-NIOSH, Morgantown, WV.<br />
#1224 CHANGES IN EXPRESSION OF TOTAL AND<br />
PHOSPHORYLATED ERK1/2 IN TCDD-<br />
EXPOSED EMBRYONIC MOUSE PALATES. C. J.<br />
Wolf and B. Abbott. Reproductive <strong>Toxicology</strong> Division,<br />
U.S. EPA, ORD, NHEERL, Research Triangle Park,<br />
NC.<br />
#1225 INTERACTIONS WITH THE TGF-β SIGNALING<br />
PATHWAY: A KEY MECHANISM OF<br />
DEVELOPMENTAL TOXICITY? T. W. Thomas 1,2<br />
and C. A. Kimmel 2 . 1 AAAS Risk Policy Fellow,<br />
Washington, DC and 2 NCEA, U.S. EPA, Washington,<br />
DC.<br />
#1226 DIABETES-INDUCED NEPHROPATHY<br />
ASSOCIATES WITH AKT AND P38 KINASE<br />
ACTIVATION. Y. Song, R. Wu, M. Barati, M. Rane<br />
and L. Cai. Medicine, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: DISPOSITION/PHARMACOKINETICS<br />
Chairperson(s): James Bruckner, University <strong>of</strong> Georgia, Athens, GA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1227 DISPOSITION OF TCDD IN A MOUSE MODEL<br />
OF OBESITY AND TYPE II DIABETES. J. J.<br />
Diliberto, M. J. DeVito, D. G. Ross, V. M. Richardson<br />
and L. S. Birnbaum. NHEERL, U.S. EPA, Research<br />
Triangle Park, NC.<br />
142<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1228 MATERNAL AND FETAL DISPOSITION OF<br />
GENISTEIN GLUCURONIDE AND SULFATE<br />
CONJUGATES FOLLOWING 14-DAY IN UTERO<br />
EXPOSURE TO GENISTEIN. N. V. Soucy, H. D.<br />
Parkinson, M. A. Sochaski and S. J. Borgh<strong>of</strong>f. CIIT<br />
Centers for Health Research, Research Triangle Park,<br />
NC.<br />
#1229 THE CANALICULAR TRANSPORTER<br />
MULTIDRUG RESISTANCE-ASSOCIATED<br />
PROTEIN 2 FACILITATES BILIARY<br />
EXCRETION OF DIETHYLSTILBESTROL. M. Z.<br />
Dieter, T. L. Callaghan and C. D. Klaassen. University<br />
<strong>of</strong> Kansas Medical Center, Kansas City, KS.<br />
#1230 DISPOSITION OF 2, 2′, 4, 4′, 5, 5′-<br />
HEXABROMODIPHENYL ETHER IN F344 RATS<br />
AND B6C3F1 MICE. E. H. Lebetkin 1 , J. M.<br />
Sanders 1,2 , A. C. Creech 1,3 and L. T. Burka 1 . 1 LPC,<br />
NIEHS, Research Triangle Park, NC, 2 Department <strong>of</strong><br />
<strong>Toxicology</strong>, NCSU, Raleigh, NC and 3 NCSU, Raleigh,<br />
NC.<br />
#1231 METABOLISM AND TISSUE DOSIMETRY OF<br />
PENTAVALENT AND TRIVALENT<br />
MONOMETHYLATED ARSENIC AFTER ORAL<br />
ADMINISTRATION IN MICE. M. F. Hughes 1 , V.<br />
Devesa 2 , B. M. Adair 1 , M. Styblo 2 , E. M. Kenyon 1 and<br />
D. J. Thomas 1 . 1 ORD/NHEERL, U.S. EPA, Research<br />
Triangle Park, NC and 2 CEMALB, University <strong>of</strong> North<br />
Carolina, Chapel Hill, NC.<br />
#1232 PHARMACOKINETIC EVALUATION OF<br />
PERFLUOROOCTANOIC ACID IN THE MOUSE.<br />
C. Lau 1 , M. J. Strynar 2 , A. B. Lindstrom 2 , R. G.<br />
Hanson 1 , J. R. Thibodeaux 1 and H. A. Barton 3 .<br />
1 Reproductive <strong>Toxicology</strong> Division, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC, 2 Human<br />
Exposure and Atmospheric Sciences Division, NERL,<br />
ORD, U.S. EPA, Research Triangle Park, NC and<br />
3 Experimental <strong>Toxicology</strong> Division, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#1233 INITIAL SKIN PENETRATION STUDY FOR<br />
DETERMINING BIS-(2-<br />
CHLOROETHOXY)METHANE (CEM)<br />
TOXICOKINETICS AFTER A SINGLE DERMAL<br />
APPLICATION IN RODENTS. S. HONG 1 , J. D.<br />
Johnson 1 , S. W. Graves 1 , B. Burback 1 , J. Merrill 1 and<br />
C. SMITH 2 . 1 Battelle Memorial Institute, Columbus,<br />
OH and 2 NIEHS, NIH, Research Triangle Park, NC.<br />
#1234 RODENT PLASMA AND TISSUE<br />
CONCENTRATION TIME COURSE DATA FOR<br />
BIS (2-CHLOROETHOXY)METHANE: A<br />
PRELIMINARY IV STUDY. J. W. Merrill 1 , J. D.<br />
Johnson 1 , S. Hong 1 , S. W. Graves 1 , B. Burback 1 and C.<br />
Smith 2 . 1 Battelle, Columbus, OH and 2 NIEHS, NIH,<br />
Research Triangle Park, NC.<br />
#1235 EFFECTS OF PARTICLE SIZE ON THE<br />
SYSTEMIC BIOAVILABILITY IN RATS<br />
FOLLOWING INHALATION EXPOSURE. S. Hu 1 ,<br />
B. Naumann 2 , M. Cwik 1 and N. Rajendran 1 . 1 IIT<br />
Research Institute, Chicago, IL and 2 Merck & Co., Inc.,<br />
Whitehouse Station, NJ.<br />
#1236 EVALUATION OF THE HALF-LIFE (T 1/2 ) OF<br />
ELIMINATION OF PERFLUOROOCTANOATE<br />
(PFOA) FROM HUMAN SERUM. D. Ehresman 1 , G.<br />
Olsen 1 , J. Burris 1 , J. Froehlich 2 , A. Seacat 1 and J.<br />
Butenh<strong>of</strong>f 1 . 1 Medical Department, 3M Company, St.<br />
Paul, MN and 2 Pace Analytical, St. Paul, MN.<br />
#1237 DISPOSITION OF [ 14 C]<br />
DECAMETHYLCYCLOPENTASILOXANE<br />
([ 14 C]D 5 ) IN FISCHER 344 RATS FOLLOWING<br />
SINGLE AND MULTIPLE INHALATION<br />
EXPOSURE. J. M. Tobin, D. A. McNett, J. A. Durham<br />
and K. P. Plotzke. Health and Environmental Sciences,<br />
Dow Corning Corporation, Auburn, MI.<br />
#1238 TOXICOKINETICS OF 14C-RDX IN MINIATURE<br />
PIGS. G. Reddy 1 , M. A. Major 1 , M. A. Berge 2 and S.<br />
Patzer 2 . 1 Directorate <strong>Toxicology</strong>, U.S.Army Center for<br />
Health Promotion and Preventive Medicine, Aberdeen<br />
Proving Ground, MD and 2 Covance Laboratories Inc.,<br />
Madison, WI.<br />
#1239 TOXICOKINETICS OF<br />
TETRABROMOBISPHENOL A IN HUMAN<br />
SUBJECTS. W. Dekant, W. Voelkel and U. Schauer.<br />
Department <strong>of</strong> toxicology, University <strong>of</strong> Wuerzburg,<br />
Wuerzburg, Germany.<br />
#1240 TISSUE DISTRIBUTION OF 14 C-<br />
ACETAMINOPHEN IN THE MONKEY USING<br />
QUANTITATIVE AUTORADIOLUMINOGRAPHY<br />
OR LIQUID SCINTILLATION COUNTING. O.<br />
Boutherin-Falson 1 , L. Faure 1 , A. Raynard 1 , M.<br />
Maynaud 1 and J. Descotes 2 . 1 MDS Pharmacology<br />
Services, St Germain s/ L’Arbresle, France and 2 Poison<br />
Center, Lyon, France.<br />
#1241 ETHYLENE GLYCOL UPTAKE IN<br />
VOLUNTEERS EXPOSED BY INHALATION AND<br />
BY THE DERMAL ROUTE. S. Upadhyay, J.<br />
Carstens, T. H. Faller, H. Greim, G. A. Csanady and J.<br />
G. Filser. <strong>Toxicology</strong>, GSF, Neuherberg, Germany.<br />
#1242 STRATEGIES TO ASSESS SYSTEMIC<br />
EXPOSURE OF TEST MATERIAL IN<br />
SUBCHRONIC STUDIES. S. A. Saghir, A. L.<br />
Mendrala, M. J. Bartels, S. J. Day, S. C. Hansen, J. M.<br />
Sushynski and J. S. Bus. <strong>Toxicology</strong> & Environmental<br />
Research & Consulting, The Dow Chemical Company,<br />
Midland, MI.<br />
#1243 THE EFFECT OF DOSE ON THE METABOLIC<br />
PROFILE OF TRICHLOROETHYLENE. C. Hines 2 ,<br />
S. Muralidhara 2 , C. A. White 2 and J. V. Bruckner 2 .<br />
1 2 University Of Georgia, Athens, GA, Pharmaceutical<br />
and Biomedical Sciences, UGA, Athens, GA, 3 UGA,<br />
Athens, GA and 4 UGA, Athens, GA.<br />
#1244 MATERNAL AND FETAL DISPOSITION OF<br />
LAMIVUDINE, ZIDOVUDINE, AND<br />
LAMIVUDINE-ZIDOVUDINE IN THE<br />
PREGNANT RAT. S. Lewis 1 , Y. Alnouti 2 , M. Bartlett 1<br />
and C. White 1 . 1 Pharmaceutical and Biomedical<br />
Sciences, University <strong>of</strong> Georgia, Athens, GA and<br />
2 University <strong>of</strong> Kansas Medical Center, Kansas City, KS.<br />
Sponsor: J. Bruckner.<br />
TUESDAY<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1245 TOXICOKINETICS OF DELTAMETHRIN IN<br />
DIFFERENT VEHICLES IN RATS. H. J. Kim, K.<br />
Kim, S. Muralidhara and J. V. Bruckner. Pharmaceutical<br />
and Biomedical Sciences, University <strong>of</strong> Georgia,<br />
Athens, GA.<br />
#1246 PHARMACOKINETICS AND TOXICOKINETICS<br />
OF PHOSPHORODIAMIDATE MORPHOLINO<br />
OLIGOMERS AGAINST HEPATITIS C VIRUS<br />
AFTER SINGLE INTRAVENOUS INJECTION. A.<br />
Amantana, M. Cate, M. Reddy, D. Weller and P.<br />
Iversen. <strong>Toxicology</strong>, AVIBioPharma, Inc., Corvallis,<br />
OR.<br />
#1247 TOXICOKINETIC STUDY FOR<br />
DELTAMETHRIN AND ITS METABOLITE, 3-<br />
PHENOXYBENZOIC ACID, IN IMMATURE AND<br />
ADULT RATS. K. Kim, J. V. Bruckner and H. Kim.<br />
Pharmaceutical and Biomedical Sciences, University <strong>of</strong><br />
Georgia, Athens, GA.<br />
#1248 UPTAKE AND DISPOSITION OF INHALED<br />
METHANOL VAPORS IN HUMANS. L. Ernstgard 1 ,<br />
G. Johanson 1 and E. Shibata 2 . 1 Institute <strong>of</strong><br />
Environmental Medicine, Karolinska Institutet,<br />
Stockholm, Sweden and 2 Department <strong>of</strong> Health and<br />
Psycosocial Medicine, Aichi Medical University School<br />
<strong>of</strong> Medicine, Nagakute-cho, Japan.<br />
#1249 PERCUTANEOUS ABSORPTION OF WATER<br />
SOLUTION OF TRICHLOROETHYLENE IN<br />
VOLUNTEERS DURING PRE-STEADY AND<br />
STEADY STATE. I. Jakasa 1 , J. Kruse 2 and S. Kezic 1 .<br />
1 Coronel Institute, Academic Medical Centre,<br />
Amsterdam, Netherlands and 2 Kinetox, Vleuten,<br />
Netherlands. Sponsor: P. Boogaard.<br />
#1250 INFLUENCE OF HEPATIC CLEARANCE ON<br />
THE TOXICITY OF THE TYPE I PYRETHROIDS<br />
BIFENTHRIN AND PERMETHRIN. E. J. Scollon 1 ,<br />
R. Tornero-Velez 2 , S. J. Godin 3 , M. F. Hughes 1 and M. J.<br />
DeVito 1 . 1 ORD/NHEERL, U.S. EPA, Research Triangle<br />
Park, NC, 2 ORD/NERL, U.S. EPA, Research Triangle<br />
Park, NC and 3 Curriculum in <strong>Toxicology</strong>, University <strong>of</strong><br />
North Carolina, Chapel Hill, NC.<br />
#1251 METABOLISM OF DI(2-ETHYLHEXYL)<br />
PHTHALATE (DEHP) IN JUVENILE AND FETAL<br />
MARMOSET AND RAT. Y. Kurata, F. Makinodan, N.<br />
Shimamura, M. Okada and M. Katoh. Mitsubishi<br />
Chemical Safety Institute Ltd.,, Ibaraki, Japan. Sponsor:<br />
M. Tsuchitani.<br />
#1252 TRANSPLACENTAL TOXICOKINETICS OF 3’-<br />
AZIDO-3’-DEOXYTHYMIDINE (AZT) IN MICE.<br />
B. Collins 2 , S. Black 1 , P. Patel 1 , J. Demeter 1 , J. Blake 1 ,<br />
S. Cooper 1 , R. Fernando 1 , M. Veselica 1 and C. Garner 1 .<br />
1 DMPK, RTI International, Research Triangle Park, NC<br />
and 2 NIEHS, Research Triangle Park, NC.<br />
#1253 DISPOSITION OF BDE 99 AND BDE 153 IN<br />
FEMALE MICE. D. Bauer 1 , D. F. Staskal 1 , J. J.<br />
Dileberto 2 and L. S. Birnbaum 2 . 1 Curriculum in<br />
<strong>Toxicology</strong>, University <strong>of</strong> North Carolina–Chapel Hill,<br />
Chapel Hill, NC and 2 Experimental <strong>Toxicology</strong><br />
Division, U.S. EPA, Research Triangle Park, NC.<br />
#1254 DEVELOPMENT OF AN IN VITRO BLOOD-<br />
BRAIN BARRIER MODEL FOR BRAIN<br />
DISPOSITION SCREENING OF<br />
PHARMACEUTICALS. G. Stolper, M. Klausner, J. E.<br />
Sheasgreen and P. J. Hayden. MatTek Corp., Ashland,<br />
MA.<br />
#1255 PHARMACOKINETICS OF TAFA93, A NOVEL<br />
PRO-DRUG OF THE MTOR INHIBITOR<br />
RAPAMYCIN. D. G. Freitag, M. D. Abel, L. J.<br />
Aspeslet, P. R. Mayo, R. S. Barber, D. J. Trepanier, D.<br />
Ure, R. T. Foster and R. W. Yatsc<strong>of</strong>f. Isotechnika,<br />
Edmonton, AB, Canada. Sponsor: J. Daniels.<br />
#1256 RAT STRAIN DIFFERENCES IN ETHYLENE<br />
GLYCOL RENAL TOXICITY IS DRIVEN BY THE<br />
RENAL CLEARANCE OF OXALIC ACID. W. M.<br />
Snellings 1 , M. Bartels 2 , R. Corley 3 , M. Dryzga 2 , D.<br />
Wilson 2 and J. Domoradzki 4 . 1 Global Environmental,<br />
Health & Safety, Dow Chemical, Danbury, CT,<br />
2 3 <strong>Toxicology</strong>, Dow Chemical, Midland, MI, Battelle<br />
Northwest, Richland, WA and 4 <strong>Toxicology</strong>, Dow<br />
Corning, Midland, MI.<br />
#1257 DBDPO METABOLISM IN FISH AND<br />
MAMMALS: CONTRIBUTION TO LOWER<br />
BROMINATED DIPHENYL ETHERS. M. Hardy.<br />
Albemarle Corporation, Baton Rouge, LA.<br />
#1258 BIO-PHYSICO CHEMICAL DETERMINANTS OF<br />
TIME-TO-STEADY STATE FOR VOLATILE<br />
ORGANIC COMPOUNDS (VOCS). D. A. Manca, G.<br />
Balagopal and P. Welsh. Standards Development<br />
Branch, Ontario Ministry <strong>of</strong> the Environment, Toronto,<br />
ON, Canada.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: GENETIC POLYMORPHISMS<br />
Chairperson(s): Steven Myers, University <strong>of</strong> Louisville, Louisville, KY.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1259 RELATIONSHIP BETWEEN CYP1A1 GENOTYPE<br />
AND BENZO(A)PYRENE (BP) HEMOGLOBIN<br />
(HB) ADDUCTS IN MATERNAL AND FETAL<br />
BLOOD. T. Wright, C. Cunningham and S. R. Myers.<br />
Pharmacology and <strong>Toxicology</strong>, Center for<br />
Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#1260 ASSOCIATION BETWEEN GENETIC<br />
POLYMORPHISMS IN CYP1A1 AND CYP17,<br />
RACE, AND TAMOXIFEN SIDE EFFECTS IN<br />
BREAST CANCER PATIENTS. M. M. Diawara 1 , J.<br />
B. Babus 2 , L. M. Lewis 2 and J. A. Flaws 2 . 1 Biology,<br />
Colorado State University-Pueblo, Pueblo, CO and<br />
2 Epidemiology and Prev. Medicine, University <strong>of</strong><br />
Maryland School <strong>of</strong> Medicine, Baltimore, MD.<br />
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SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
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<strong>Program</strong> Description<br />
#1261 STRUCTURAL HETEROGENEITY AT THE UDP-<br />
GLUCURONOSYLTRANSFERASE 1A LOCUS IN<br />
A KOREAN POPULATION. S. Yea 1,2 , W. Kim 2 , S.<br />
Lee 2 , J. Sohn 2 , S. Oh 2 , Y. Park 1 and J. Shin 2 .<br />
1 Department <strong>of</strong> Biochemistry, Inje University, Pusan,<br />
Korea, South Korea and 2 PharmacoGenomics Research<br />
Center, Inje University, Pusan, South Korea. Sponsor:<br />
H. Kim.<br />
#1262 ROLE OF ALCOHOL DEHYDROGENASE<br />
GENOTYPE IN PREDICTING DEVELOPMENT<br />
OF FETAL ALCOHOL SYNDROME (FAS). N. M.<br />
Spiegl 1 , J. L. Powell 1 , K. S. Squibb 1 , K. A. Strauss 1 , J.<br />
O’Kane 2 and J. D. Cook 2 . 1 Epidemiology and<br />
Preventive Medicine, University <strong>of</strong> Maryland School <strong>of</strong><br />
Medicine, Baltimore, MD and 2 Medical and Research<br />
Technology, University <strong>of</strong> Maryland School <strong>of</strong><br />
Medicine, Baltimore, MD.<br />
#1263 CHARACTERIZATION OF THE VAL108MET<br />
COMT POLYMORPHISM. A. E. Doyle 1 , B. L.<br />
McAtee 1 , J. P. Bressler 1,2 , P. M. Silber 3 and J. D.<br />
Yager 1 . 1 Environmental Health Sciences, Johns Hopkins<br />
University, Baltimore, MD, 2 Kennedy-Krieger Institute,<br />
Baltimore, MD and 3 In Vitro Technologies, Inc.,<br />
Baltimore, MD.<br />
#1264 POLYMORPHISM IN N-ACETYLTRANSFERASE<br />
1 ALLELES NAT1*10 AND NAT1*14A IN<br />
BENZIDINE-EXPOSED WORKERS IN THE<br />
CHINESE DYESTUFF INDUSTRY: LACK OF<br />
ASSOCIATION WITH CYTOLOGICAL<br />
GRADING OF EXFOLIATED UROTHELIAL<br />
CELLS. W. Guo 1 , G. Lin 1 , J. Chen 2 , K. Golka 3 and J.<br />
Shen 1 . 1 Institute <strong>of</strong> Plant Physiology and Ecology,<br />
Shanghai Institutes for Biological Sciences, Chinese<br />
Academy <strong>of</strong> Sciences, Shanghai, China, 2 Municipal<br />
Center for Disease Prevention and Control, Shanghai,<br />
China and 3 Institute for Occupational Physiology at the<br />
University <strong>of</strong> Dortmund, Dortmund, Germany.<br />
#1265 INDIRECT EVIDENCE FOR EXTRAGENIC<br />
AND/OR ENVIRONMENTAL INFLUENCE ON<br />
HUMAN NAT1 EXPRESSION: ANALYSIS OF<br />
PRIMARY HEPATOCYTES BY ALLELE-<br />
SPECIFIC QUANTITATIVE REAL-TIME RT-<br />
PCR. J. M. Walraven, D. F. Barker, M. A. Doll and D.<br />
W. Hein. Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong><br />
Louisville, Louisville, KY.<br />
#1266 FUNCTIONAL CHARACTERIZATION OF<br />
MOUSE N-ACETYLTRANSFERASES IN A NAT2<br />
KNOCKOUT MODEL. J. A. Loehle 1 , L. Wakefield 2 ,<br />
H. Long 2 , M. A. Doll 1 , J. R. Neale 1 , E. Sim 2 and D. W.<br />
Hein 1 . 1 Pharmacology/<strong>Toxicology</strong>, University <strong>of</strong><br />
Louisville, Louisville, KY and 2 Pharmacology,<br />
University <strong>of</strong> Oxford, Oxford, United Kingdom.<br />
#1267 MECHANISTIC STUDY OF THE A 411 T (L137F)<br />
GENETIC POLYMORPHISM IN HUMAN N-<br />
ACETYLTRANSFERASE 2. Y. Zang, S. Zhao, J.<br />
States and D. W. Hein. Pharmacology & <strong>Toxicology</strong>,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#1268 PARAOXONASE POLYMORPHISM LEU-MET55<br />
AND ITS RELATIONSHIP TO DIABETIC<br />
COMPLICATIONS IN PATIENTS WITH NON-<br />
INSULIN-DEPENDENT DIABETES MELLITUS.<br />
A. KARAKAYA. <strong>Toxicology</strong>, Ankara University,<br />
Ankara, Turkey. Sponsor: A. Ankara University.<br />
#1269 GSTM1, GSTM3 AND SMOKING HABITS IN<br />
BLADDER CANCER CASES FROM TWO<br />
DIFFERENT INDUSTRIAL AREAS. K. Golka 1 , T.<br />
Schmidt 1 , T. Seidel 2 , H. Dietrich 2 , H. Roemer 1,3 , D.<br />
Loehlein 3 , T. Reckwitz 4 , J. Soekeland 1,4 , R. Thier 1 and<br />
S. Selinski 5 . 1 Institute for Occupational Physiology at<br />
the University <strong>of</strong> Dortmund, Dortmund, Germany,<br />
2 Department <strong>of</strong> Urology, Lutherstadt Wittenberg,<br />
Germany, 3 Department <strong>of</strong> Surgery, Klinikum,<br />
Dortmund, Germany, 4 Department <strong>of</strong> Urology,<br />
Klinikum, Dortmund, Germany and 5 Department <strong>of</strong><br />
Statistics, University <strong>of</strong> Dortmund, Dortmund,<br />
Germany.<br />
#1270 GST-T1, P53, AND CASPASE-8 POLYMORPHISMS<br />
AND COLON CANCER RISK. J. Goodman 1,2 and C.<br />
C. Harris 2 . 1 Gradient Corporation, Cambridge, MA and<br />
2 Laboratory <strong>of</strong> Human Carcinogenesis, National Cancer<br />
Institute, Bethesda, MD.<br />
#1271 THE GLUTAMATE CYSTEINE LIGASE<br />
CATALYTIC SUBUNIT -129 C/T SINGLE<br />
NUCLEOTIDE POLYMORPHISM IS<br />
ASSOCIATED WITH THE LEVEL OF GAD65<br />
AUTOANTIBODIES IN TYPE 1 DIABETES<br />
PATIENTS WITH A DELAYED AGE-AT-ONSET. L.<br />
M. Bekris 1 , M. Janer 2 , T. J. Kavanagh 1 and A.<br />
Lernmark 3 . 1 Environmental and Occupational Health<br />
Sciences, University <strong>of</strong> Washington, Seattle, WA,<br />
2 Institute for Systems Biology, Seattle, WA and<br />
3 Medicine, University <strong>of</strong> Washington, Seattle, WA.<br />
#1272 BIOLOGICAL CHARACTERIZATION OF THE<br />
MANGANESE SUPEROXIDE DISMUTASE<br />
(MNSOD) VAL-9ALA POLYMORPHISM. B. L.<br />
McAtee, A. E. Doyle and J. D. Yager. Environmental<br />
Health Sciences, Johns Hopkins Bloomberg School <strong>of</strong><br />
Public Health, Baltimore, MD.<br />
#1273 MOLECULAR ANALYSIS OF<br />
DIHYDROPYRIMIDINE DEHYDROGENASE<br />
AND THYMIDYLATE SYNTHASE GENE<br />
POLYMORPHISMS IN A TURKISH<br />
POPULATION. S. Suzen, N. Yuce, G. Guvenc and Y.<br />
Duydu. <strong>Toxicology</strong>, Ankara University, Ankara, Turkey.<br />
Sponsor: S. Suzen.<br />
#1274 TWO POLYMORPHISMS IN THE DNA REPAIR<br />
GENE MGMT INCREASE HUMAN SENSITIVITY<br />
TO THE TOBACCO-SPECIFIC NITROSAMINE<br />
NNK. C. E. Hill, A. A. Affatato, K. J. Wolfe, J. K.<br />
Wickliffe and S. Z. Abdel-Rahman. PMCH-<br />
Environmental <strong>Toxicology</strong>, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX.<br />
#1275 ASSOCIATIONS BETWEEN MERCURY, BDNF<br />
POLYMORPHISM, AND ATTENTIONAL<br />
ATTRIBUTES OF MOTOR FUNCTION. D.<br />
echeverria 1,2 , J. S. Woods 1,2 , N. J. Heyer 1 , F. M. Farin 2 ,<br />
A. C. Bittner 1 , T. Li 2 and C. Garabedian 1 . 1 Battelle<br />
CPHRE, Seattle, WA and 2 ENVH, U <strong>of</strong> Washington,<br />
Seattle, WA.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 145
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
TUESDAY<br />
#1276 IDENTIFICATION OF A NOVEL VARIANT OF<br />
THE PREGNANE X RECEPTOR IN HEPATIC<br />
ADVERSE DRUG REACTION PATIENTS. J. D.<br />
Tugwood 1 , D. F. Carr 2 and H. Pringle 2 . 1 Safety<br />
Assessment, AstraZeneca Pharmaceuticals,<br />
Macclesfield, United Kingdom and 2 University <strong>of</strong><br />
Leicester, Leicester, United Kingdom. Sponsor: F.<br />
Pognan.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: BIOMONITORING<br />
Chairperson(s): Steven Myers, University <strong>of</strong> Louisville, Louisville, KY and<br />
Xia<strong>of</strong>ei Zhang, UC Riverside, Riverside, CA.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1277 MEASURING CHOLINESTERASE ACTIVITY IN<br />
HUMAN SALIVA. B. Claus Henn 1,2,3 , S. Padilla 2 and<br />
S. McMaster 3 . 1 ASPH Research Fellow, Research<br />
Triangle Park, NC, 2 NTD, U.S. EPA, Research Triangle<br />
Park, NC and 3 HSD, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#1278 A CONVERSION FACTOR BETWEEN TWO<br />
CHOLINESTERASE ASSAYS AND ITS<br />
APPLICATION IN ESTABLISHING A NORMAL<br />
RANGE FOR HUMAN RBC ACHE. D. E. Arrieta 1 ,<br />
V. M. Nihart 1 , J. D. Henderson 1 , S. A. McCurdy 2 , L. J.<br />
Lefkowitz 3 and B. W. Wilson 1 . 1 Environmental<br />
<strong>Toxicology</strong> and Animal Science, University <strong>of</strong><br />
California, Davis, CA, 2 Epidemiology and Preventive<br />
Medicine, University <strong>of</strong> California, Davis, CA and 3 US<br />
Army Center for Health Promotion and Preventive<br />
Medicine, Aberdeen Proving Ground, MD.<br />
#1279 PESTICIDE EXPOSURE ASSESSMENT:<br />
CONCURRENT PASSIVE DOSIMETRY AND<br />
BIOLOGICAL MONITORING OF TRICLOPYR<br />
AND 2, 4-D EXPOSURES OF A BACKPACK<br />
APPLICATOR CREW. X. Zhang 1,2 , S. P. Acevedo 1 , Y.<br />
Chao 1 , T. M. Din<strong>of</strong>f 1 , R. L. Williams 1,2 and R. I.<br />
Krieger 1,2 . 1 Personal Chemical Expsosure <strong>Program</strong>,<br />
Department <strong>of</strong> Entomology, University <strong>of</strong> California,<br />
Riverside, CA and 2 Environmental <strong>Toxicology</strong> Graduate<br />
<strong>Program</strong>, University <strong>of</strong> California, Riverside, CA.<br />
#1280 ENVIRONMENTAL INDUCTION OF CYP1A-,<br />
CYP2M1- AND CYP2K1-LIKE PROTEINS IN<br />
TROPICAL FISH SPECIES BY PRODUCED<br />
FORMATION WATER ON THE NORTHWEST<br />
SHELF OF AUSTRALIA. S. Zhu 1 , S. CodiKing 2 and<br />
M. L. Haasch 1 . 1 Pharmacology, Environmental<br />
<strong>Toxicology</strong> Research <strong>Program</strong>, NCNPR, University <strong>of</strong><br />
Mississippi, University, MS and 2 Australian Institute <strong>of</strong><br />
Marine Science, Townsville, QLD, Australia.<br />
#1281 ANALYSIS OF ENVIRONMENTAL<br />
POLLUTANTS IN BREAST MILK AND DNA<br />
DAMAGE IN BREAST-MILK CELLS. K. F.<br />
Arcaro 1,2 , J. W. Staudenmayer 3 , A. P. DeCaprio 3 , J.<br />
Wang 1 and M. T. Reece 3 . 1 Environmental Sciences,<br />
Univeristy <strong>of</strong> Massachusetts, Amherst, MA, 2 Veterinary<br />
& Animal Sciences, University <strong>of</strong> Massachusetts,<br />
Amherst, MA and 3 University <strong>of</strong> Massachusetts,<br />
Amherst, MA.<br />
#1282 AMBIENT AND BIOLOGICAL MONITORING OF<br />
EXPOSURE TO AROMATIC AMINES IN THE<br />
RUBBER INDUSTRY. T. Weiss 1,2 , H. U. Kaefferlein 2 ,<br />
T. Bruening 2 and J. Angerer 1 . 1 Institute <strong>of</strong> Occupational<br />
Medicine, Friedrich-Alexander University, Erlangen,<br />
Germany and 2 Institute <strong>of</strong> Occupational<br />
Medicine–Center <strong>of</strong> <strong>Toxicology</strong>, Ruhr-University,<br />
Bochum, Germany.<br />
#1283 SINGLE NUCLEOTIDE POLYMORPHISM AT<br />
EXON 4 IN THE MICROSOMAL EPOXIDE<br />
HYDROLASE GENE IS ASSOCIATED WITH<br />
INCREASED AFLATOXIN ALBUMIN ADDUCTS<br />
IN THE BLOOD OF HUMANS IN GHANA. B.<br />
Dash 1 , E. Afriyie-Gyawu 1 , H. J. Huebner 1 , J. Wang 2 , P.<br />
E. Jolly 3 and T. D. Phillips 1 . 1 Faculty <strong>of</strong> <strong>Toxicology</strong>,<br />
Texas A&M University, College Station, TX, 2 Texas<br />
Tech University, Lubbock, TX and 3 University <strong>of</strong><br />
Alabama, Birmingham, AL.<br />
#1284 CORRELATION OF MATERNAL HEMOGLOBIN<br />
(HB) 4-AMINOBIPHENYL ADDUCT LEVELS<br />
WITH RESPECT TO COTININE LEVELS AND<br />
MATERNAL GENOTYPES. S. R. Myers, C.<br />
Cunningham and T. Wright. Pharmacology and<br />
<strong>Toxicology</strong>, Center for Environmental and Occupational<br />
Health Sciences, University <strong>of</strong> Louisville, Louisville,<br />
KY.<br />
#1285 CORRELATION OF MATERNAL AND FETAL<br />
HEMOGLOBIN (HB) ADDUCTS IN SMOKERS<br />
WITH RESPECT TO GENOTYPE. C. Cunningham,<br />
T. Wright and S. R. Myers. Pharmacology and<br />
<strong>Toxicology</strong>, Center for Environmental and Occupational<br />
Health Sciences, University <strong>of</strong> Louisville, Louisville,<br />
KY.<br />
#1286 LEVELS OF POLYCYCLIC AROMATIC<br />
HYDROCARBONS IN AMNIOTIC FLUID<br />
SAMPLES FROM SMOKERS AND<br />
NONSMOKERS. J. Weeks and S. R. Myers.<br />
Pharmacology and <strong>Toxicology</strong>, Center for<br />
Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#1287 INVESTIGATIONS OF VARIATION IN URINARY<br />
PROFILES BETWEEN SMOKERS AND NON-<br />
SMOKERS USING METABONOMIC (NMR<br />
SPECTROSCOPIC) URINALYSIS. M. Ogden. R&D,<br />
R. J. Reynolds, Winston-Salem, NC. Sponsor: D.<br />
Doolittle.<br />
146<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1288 RACE/ETHNICITY, INCOME AND<br />
PERCHLOROETHYLENE (PERC) EXPOSURES<br />
AMONG ADULT AND CHILD RESIDENTS OF<br />
BUILDINGS WITH DRY CLEANERS. J. E. Storm 1 ,<br />
M. J. McDermott 1 , K. M. Aldous 1 , B. C. Blount 2 , J.<br />
Serle 3 and S. J. Shost 1 . 1 Department <strong>of</strong> Health, New<br />
York State, Troy, NY, 2 US Centers for Disease Control<br />
and Prevention, Atlanta, GA and 3 Mt. Sinai School <strong>of</strong><br />
Medicine, New York.<br />
#1289 HEALTH EVALUATION OF MARINE FISHES<br />
FROM JOHNSTON ATOLL NATIONAL<br />
WILDLIFE REFUGE, A FORMER MILITARY<br />
INSTALLATION. D. M. Papoulias 1 , J. L. Zajicek 1 , M.<br />
L. Annis 1 , D. K. Nicks 1 , J. S. Candrl 1 , L. Woodward 2<br />
and D. E. Tillitt 1 . 1 USGS, Columbia Environmental<br />
Research Center, Columbia, MO and 2 USFWS,<br />
Honolulu, HI. Sponsor: C. Richter.<br />
#1290 EXPOSURE ASSESSMENT IN CONTAMINATED<br />
ENVIRONMENTS. R. A. Lingenfelter 1 , L. Cizmas 1 ,<br />
Z. Naufal 1 , C. Naspinski 1 , L. He 1 , G. Zhou 1 , T.<br />
McDonald 1 , G. Denoux 1 , R. Autenrieth 1 , A. Mekhtiev 3 ,<br />
A. Islamzadeh 2 and K. Donnelly 1 . 1 Texas A&M<br />
University, College Station, TX, 2 Institute <strong>of</strong> Physiology<br />
n.a. A.I.Karaev, Baku, Azerbaijan and 3 Sumgayit Centre<br />
For Environmental Rehabilitation, Sumgayit,<br />
Azerbaijan.<br />
#1291 INTEGRATION OF BIOMONITORING DATA<br />
INTO THE RISK ASSESSMENT PROCESS. S. H.<br />
Robison 1 , L. Needham 2 , E. Faustman 3 , H. Zenick 4 and<br />
L. Sheldon 5 . 1 Procter & Gamble, Cincinnati, OH, 2 CDC,<br />
Atlanta, GA, 3 University <strong>of</strong> Washington, Seattle, WA,<br />
4 NHEERL, U.S. EPA, Research Triangle Park, NC and<br />
5 NERL, U.S. EPA, Research Triangle Park, NC.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: STATISTICAL AND BIOLOGICAL MODELS<br />
Chairperson(s): Julia Kimbell, CIIT Centers for Health Research, Research<br />
Triangle Park, NC and Michael Zager, University <strong>of</strong> North Carolina, Research<br />
Triangle Park, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1292 A FLEXIBLE APPROACH FOR EVALUATING<br />
FIXED RATIO MIXTURES OF FULL AND<br />
PARTIAL AGONISTS FOR MIXTURES OF MANY<br />
CHEMICALS. C. Gennings 1,2 , H. Carter 1,2 , R. A.<br />
Carchman 2 , M. J. DeVito 3 , J. Simmons 3 and K. M.<br />
Cr<strong>of</strong>ton 3 . 1 Biostatistics, Virginia Commonwealth<br />
University, Richmond, VA, 2 Solveritas, LLC,<br />
Richmond, VA and 3 NHEERL, ORD, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#1293 A BAYESIAN NETWORK MODEL TO PREDICT<br />
HAZARD POTENCY FOR SKIN SENSITISATION.<br />
D. Jefferies, L. J. Aspinall, R. J. Safford, C. J. Clapp, A.<br />
Madrigal, M. Chamberlain and D. A. Basketter. Safety<br />
and Environmental Assurance Centre, Unilever,<br />
Bedford, United Kingdom.<br />
#1294 TOXICITY-RELATED MOLECULAR<br />
PARAMETERS CALCULATED FOR<br />
ALDEHYDES AND KETONES FOUND IN<br />
DIESEL EXHAUST. P. Martin 1 , R. Garg 2 , M. C.<br />
Madden 3 and C. J. Smith 1 . 1 Lorillard Tobacco Co.,<br />
Greensboro, NC, 2 Chemistry, Clarkson University,<br />
Potsdam, NY and 3 U.S. EPA NHEERL, Research<br />
Triangle Park, NC.<br />
#1295 THREE-DIMENSIONAL ANATOMICAL<br />
RECONSTRUCTION OF THE UPPER<br />
RESPIRATORY TRACT OF B6C3F1 MICE. E. A.<br />
Gross 1 , D. R. Joyner 1 , A. M. Jarabek 1,2 and J. S.<br />
Kimbell 1 . 1 CIIT Centers for Health Research, Research<br />
Triangle Park, NC and 2 National Center for<br />
Environmental Assessment, U.S. EPA, Washington, DC.<br />
#1296 A PHARMACOKINETIC-PHARMACODYNAMIC<br />
MODEL FOR GENE-REGULATED PROSTATE<br />
MAINTENANCE: COMPARING THE EFFECTS<br />
OF CASTRATION WITH ANTIANDROGEN<br />
EXPOSURE IN THE RAT. M. G. Zager 1,2 , L. K.<br />
Potter 1,2 and H. A. Barton 2 . 1 <strong>Toxicology</strong>, University <strong>of</strong><br />
North Carolina, Research Triangle Park, NC and 2 ORD,<br />
NHEERL, U.S. EPA, Research Triangle Park, NC.<br />
#1297 PHYSIOLOGICALLY BASED<br />
PHARMACOKINETIC/PHARMACODYNAMIC<br />
MODELING FOR THE N-METHYL<br />
CARBAMATE PESTICIDE CARBARYL:<br />
INSIGHT INTO MECHANISM AND RISK<br />
ASSESSMENT. J. Wang 1 , Y. Tan 1 , A. Tobia 2 , C.<br />
Lunchick 2 , M. Krolski 2 and R. B. Conolly 1 . 1 CIIT<br />
Centers for Health Research, Research Triangle Park,<br />
NC and 2 Bayer CropScience, Research Triangle Park,<br />
NC.<br />
#1298 USE OF EXPOSURE RELATED DOSE<br />
ESTIMATING MODEL (ERDEM) FOR<br />
ASSESSMENT OF AGGREGATE EXPOSURE OF<br />
INFANTS AND CHILDREN TO N-METHYL<br />
CARBAMATE INSECTICIDES. F. W. Power 1 , M.<br />
Okino 1 , J. B. Knaak 4 , R. Tornero-Velez 2 , A. Lowit 3 , J.<br />
N. Blancato 2 and C. C. Dary 1 . 1 NERL\EDRB, U.S.<br />
EPA, Las Vegas, NV, 2 NERL, U.S. EPA, Research<br />
Triangle Park, NC, 3 Office <strong>of</strong> Pesticide <strong>Program</strong>s, U.S.<br />
EPA, Washington, DC and 4 Pharmacology and<br />
<strong>Toxicology</strong>, SUNY, Buffalo, Buffalo, NY.<br />
#1299 SPATIAL/TEMPORAL MODELING OF<br />
CYTOCHROME P450-MEDIATED<br />
PHOSPHOROTHIONATE INSECTICIDE<br />
METABOLISM IN THE RAT LIVER ACINUS. J. E.<br />
Chambers 1 , J. G. Baravik 1 , S. C. Burgess 1 , D. E.<br />
MaryBeth 1 , E. C. Meek 1 , S. F. Oppenheimer 2 and E. B.<br />
Shows 1 . 1 Center for Environmental Health Sciences,<br />
Mississippi State University, Mississippi State, MS and<br />
2 Department <strong>of</strong> Mathematics and Statistics, Mississippi<br />
State University, Mississippi State, MS.<br />
#1300 BIOTRANS: A NEW TOOL FOR PREDICTING<br />
THE METABOLISM OF CHEMICAL MIXTURES.<br />
A. N. Mayeno, R. S. Yang and B. Reisfeld. Quantitative<br />
and Computational <strong>Toxicology</strong> Group, Center for<br />
Environmental <strong>Toxicology</strong> and Technology, Colorado<br />
State University, Fort Collins, CO.<br />
TUESDAY<br />
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TUESDAY<br />
#1301 INTER-INDIVIDUAL VARIABILITY IN<br />
BENZENE METABOLITES. S. Kim 1 , R. Vermeulen 2 ,<br />
S. Waidyanatha 1 , Q. Lan 2 , M. T. Smith 3 , G. L. Li 4 , L.<br />
Zhang 3 , M. Shen 2 , S. Yin 4 , N. Rothman 2 and S. M.<br />
Rappaport 1 . 1 SPH, UNC, Chapel Hill, NC,<br />
2 3 NCI/NIH/DHHS, Bethesda, MD, SPH, UC, Berkeley,<br />
CA and 4 Chinese CDC, Beijing, China. Sponsor: I.<br />
Rusyn.<br />
#1302 USING OBSERVED VARIABILITY AS A<br />
CRITERION FOR CELLULAR KINETICS<br />
MODELS AFTER FURAN EXPOSURE. M. V.<br />
Smith 1 , R. R. Maronpot 2 , T. L. Goldsworthy 3 , R. W.<br />
Morris 4 and C. J. Portier 5 . 1 Constella Health Sciences,<br />
Constella Group, Durham, NC, NC, 2 Experimental<br />
Pathology, NIEHS, Research Triangle Park, NC,<br />
3 Integrated Laboratory Systems, Inc., Research Triangle<br />
Park, NC, 4 Anesthesiology, Duke University Medical<br />
Center, Durhan, NC and 5 Computational Biology and<br />
Risk Assessment, NIEHS, Research Triangle Park, NC.<br />
#1303 QUANTITATIVE MODELS OF BYSTANDER<br />
EFFECTS FROM IONIZING RADIATION IN<br />
NON-TARGETED CELLS. W. C. Griffith, E. Vigoren<br />
and E. Faustman. University <strong>of</strong> Washington, Seattle,<br />
WA.<br />
#1304 A MECHANISTIC MODEL OF LIFETIME<br />
CANCER RISK FOR INHALATION EXPOSURES<br />
TO REACTIVE GASES. J. Kimbell 1 , D. L. Kalisak 1 ,<br />
R. B. Conolly 1 , F. J. Miller 1 and A. M. Jarabek 1,2 . 1 CIIT<br />
Centers for Health Research, Research Triangle Park,<br />
NC and 2 National Center for Environmental<br />
Assessment, U.S. EPA, Washington, DC.<br />
#1305 PRELIMINARY DEVELOPMENT OF A<br />
MECHANISTIC THYROID HORMONE MODEL.<br />
E. A. Merrill 1 , J. M. Gearhart 2 , P. J. Robinson 2 , T. R.<br />
Sterner 3 and D. R. Mattie 4 . 1 Geo-Centers, Inc., Wright-<br />
Patterson AFB, OH, 2 ManTech, Inc., Wright-Patterson<br />
AFB, OH, 3 OpTech, Corp., Dayton, OH and<br />
4 AFRL/HEPB, Wright-Patterson AFB, OH.<br />
#1306 BIOLOGICALLY-BASED MODELING OF THE<br />
SPONTANEOUS TRANSFORMATION OF<br />
HUMAN KEROTINOCYTES, RHEK-1. E. E.<br />
Perrigo, O. Lohitnavy, J. A. Campain, B. Reisfeld and R.<br />
Yang. Quantitative and Computational <strong>Toxicology</strong><br />
Group, Center for Environmental <strong>Toxicology</strong> and<br />
Technology, Department <strong>of</strong> Environmental and<br />
Radiological Health Sciences, Colorado State<br />
University, Fort Collins, CO.<br />
Tuesday Afternoon, March 8<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: FOOD SAFETY AND NUTRITION<br />
TOXICOLOGY II<br />
Chairperson(s): Christopher Chengelis, WIL Research, Ashland, OH and<br />
John Watkins, Indiana University School <strong>of</strong> Medicine, Bloomington, IN.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1307 EVALUATION OF MOUSE MODELS FOR<br />
ASSESSING THE ALLERGENIC POTENTIAL OF<br />
PROTEINS. K. Thomas 1 , C. Herouet 2 , G. Bannon 3 , G.<br />
Ladics 4 , S. MacIntosh 5 , L. Privalle 6 and M. Woolhiser 7 .<br />
1 ILSI Health and Environmental Sciences Institute,<br />
Washington, DC, 2 Bayer CropScience, Sophia<br />
Antipolis, France, 3 Monsanto, St. Louis, MO, 4 DuPont<br />
Company, Newark, DE, 5 Bayer BioScience, Research<br />
Triangle Park, NC, 6 BASF, Research Triangle Park, NC<br />
and 7 The Dow Chemical Company, Midland, MI.<br />
#1308 VALIDATION OF FUMONISIN BIOMARKERS IN<br />
F344 RATS. Q. Cai 1,2 , H. Guan 1,2 , L. Tang 1,2 , H.<br />
Luo 1,2 , M. Billam 1,2 , Z. Wang 1,2 , Y. Tang 1,2 and J.<br />
Wang 1,2 . 1 Environmental <strong>Toxicology</strong>, Texas Tech<br />
University, Lubbock, TX and 2 The Institute <strong>of</strong><br />
Environmental and Human Health, Texas Tech<br />
University, Lubbock, TX.<br />
#1309 SHORT-TERM SAFETY EVALUATION OF<br />
NOVASIL IN HUMANS. J. Wang 1,2 , T. Goldston 3 , H.<br />
Luo 1,2 , M. Billam 1,2 , Z. Wang 1,2 , H. Guan 1,2 , L. Tang 1,2 ,<br />
E. Afriyie-Gyawu 4 , C. Lovett 3 , J. Griswold 3 , B. Brattin 4 ,<br />
H. J. Huebner 4 and T. D. Phillips 4 . 1 Environmental<br />
<strong>Toxicology</strong>, Texas Tech University, Lubbock, TX, 2 The<br />
Institute <strong>of</strong> Environmental and Human Health, Texas<br />
Tech University, Lubbock, TX, 3 Division <strong>of</strong> Clinical<br />
Research, TTUHSC, Lubbock, TX and 4 College <strong>of</strong><br />
Veterinary Medicine, Texas A&M University, College<br />
Station, TX.<br />
#1310 COMPARISON OF FORMALIN FIXED AND<br />
FROZEN TISSUES FOR SPHINGANINE AND<br />
SPHINGOSINE DETERMINATION FOLLOWING<br />
FUMONISIN B 1 EXPOSURE IN SWINE. W. M.<br />
Haschek 1 , S. Hsiao 1 , M. E. Tumbleson 2 , G. Tyagi 1 and<br />
P. D. Constable 3 . 1 Veterinary Pathobiology, University<br />
<strong>of</strong> Illinois at Urbana-Champaign, Urbana, IL,<br />
2 Agricultural and Biological Engineering, University <strong>of</strong><br />
Illinois at Urbana-Champaign, Urbana, IL and<br />
3 Veterinary Clinical Medicine, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL.<br />
#1311 INFLUENCE OF THE SOY ISOFLAVONES<br />
GENISTEIN AND DAIDZEIN ON THE<br />
EXPRESSION OF 17β-ESTRADIOL-<br />
METABOLIZING ENZYMES IN CULTURED<br />
MCF-7 BUS127 CELLS. L. Lehmann, L. Jiang, E. W.<br />
Lerch and M. Metzler. Institute <strong>of</strong> Food Chemistry and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Karlsruhe, Karlsruhe,<br />
Germany.<br />
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<strong>Program</strong> Description<br />
#1312 MODIFIED METHOD FOR EXTRACTION AND<br />
HPLC ANALYSIS OF SPHINGANINE AND<br />
SPHINGOSINE FROM BODY FLUIDS, CELLS<br />
AND TISSUES. M. E. Tumbleson 1 , S. Hsiao 2,3 , G. L.<br />
Bargren 3 , P. D. Constable 4 and W. M. Haschek 2,3 .<br />
1 Agricultural and Biological Engineering, University <strong>of</strong><br />
Illinois at Urbana-Champaign, Urbana, IL, 2 Veterinary<br />
Pathobiology, University <strong>of</strong> Illinois at Urbana-<br />
Champaign, Urbana, IL, 3 Veterinary Diagnostic<br />
Laboratory, University <strong>of</strong> Illinois at Urbana-Champaign,<br />
Urbana, IL and 4 Veterinary Clinical Medicine,<br />
University <strong>of</strong> Illinois at Urbana-Champaign, Urbana, IL.<br />
#1313 EFFECT OF AFLATOXIN B1 ON DRY GRIND<br />
ETHANOL PROCESS. G. S. Murthy 1 , D. E.<br />
Townsend 1 , G. L. Meerdink 2 , G. L. Bargren 2 , M. E.<br />
Tumbleson 1,2 and V. Singh 1 . 1 Agricultural and<br />
Biological Engineering, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL and 2 Veterinary<br />
Diagnostic Laboratory, University <strong>of</strong> Illinois at Urbana-<br />
Champaign, Urbana, IL. Sponsor: W. Haschek.<br />
#1314 SERUM AND URINE SPHINGANINE ARE<br />
USEFUL BIOMARKERS OF FUMONISIN B 1<br />
EXPOSURE IN SWINE DUE TO SLOW<br />
SYSTEMIC CLEARANCE. G. Tyagi 1 , S. Hsiao 1 , J.<br />
L. Marlatt 2 , M. E. Tumbleson 3 , P. D. Constable 2 , R. M.<br />
Eppley 4 and W. M. Haschek 1 . 1 Veterinary Pathobiology,<br />
University <strong>of</strong> Illinois at Urbana-Champaign, Urbana, IL,<br />
2 Veterinary Clinical Medicine, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL, 3 Agricultural and<br />
Biological Engineering, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL and 4 CFSAN, U.S.<br />
FDA, Laurel, MD.<br />
#1315 CLINOPATHOLOGY AND TISSUE<br />
SPHINGOLIPID CLEARANCE AFTER<br />
FUMONISIN B 1 EXPOSURE OF SWINE. J. L.<br />
Marlatt 1 , G. Tyagi 2 , S. Hsiao 2 , M. E. Tumbleson 3 , R. M.<br />
Eppley 4 , P. D. Constable 1 and W. M. Haschek 2 .<br />
1 Veterinary Clinical Medicine, University <strong>of</strong> Illinois at<br />
Urbana-Champaign, Urbana, IL, 2 Veterinary<br />
Pathobiology, University <strong>of</strong> Illinois at Urbana-<br />
Champaign, Urbana, IL, 3 Agricultural and Biological<br />
Engineering, University <strong>of</strong> Illinois at Urbana-<br />
Champaign, Urbana, IL and 4 CFSAN, U.S. FDA,<br />
Laurel, MD.<br />
#1316 SENSITIVE SCREENING BIOASSAY FOR<br />
DEOXYNIVALENOL DETECTION IN FOOD<br />
SAMPLES. C. A. Landgren and S. Hendrich. Food<br />
Science and Human Nutrition, Iowa State University,<br />
Ames, IA.<br />
#1317 INTEGRATION OF FDA DATABASES TO<br />
DEVELOP METHODOLOGIES FOR<br />
PREDICTIVE TOXICOLOGY. M. Cheeseman and<br />
M. Twaroski. CFSAN/OFAS, U.S. FDA, College Park,<br />
MD.<br />
#1318 MATERNAL EXPOSURE TO GENISTEIN<br />
DURING PREGNANCY SUPPRESSIVELY<br />
EFFECTS ON TUMOR INITIATION INDUCED<br />
BY 7, 12-DIMETHYLBENZ[A]ANTHRACENE IN<br />
STEROIDOGENIC ORGANS OF F1 OFFSPRING.<br />
J. Watanabe, H. Okamoto, M. Satoh and H. Nagase.<br />
Department <strong>of</strong> Hygienics, Gifu Pharmaceutical<br />
University, Gifu City, Gifu, Japan.<br />
#1319 EFFECTS OF N-6 AND N-3 POLYUNSATURATED<br />
FATTY ACIDS ON COLORECTAL<br />
CARCINOGENESIS. G. Alink 1 , B. Ommen 2 and Y.<br />
Dommels 1,2 . 1 Wageningen University, Wageningen,<br />
Netherlands and 2 TNO, Zeist, Netherlands. Sponsor: P.<br />
van Bladeren.<br />
Abstract 1320 is located on page 151.<br />
Tuesday Afternoon, March 8<br />
2:45 PM to 3:45 PM<br />
Room 215<br />
INFORMATIONAL SESSION: AN INTRODUCTION TO<br />
MICROARRAYS AND GENECHIP® TECHNOLOGY FOR<br />
TOXICOGENOMICS — PRESENTED BY AFFYMETRIX<br />
The Affymetrix GeneChip® System enables toxicologists to reliably generate,<br />
analyze, and manage large quantities <strong>of</strong> genetic information for accelerated<br />
research and biomarker discovery. This course is an introduction to GeneChip<br />
microarray design, performance, and analysis for applications in toxicogenomics.<br />
Tuesday Afternoon, March 8<br />
2:45 PM to 3:45 PM<br />
Room 223<br />
INFORMATIONAL SESSION: HEMOTOXICITY TESTING OF<br />
XENOBIOTICS AND NEW DRUGS FOR ALL STAGES OF THE DRUG<br />
DEVELOPMENT PIPELINE THE HALO PLATFORM - IN VITRO<br />
HEMOTOXICITY TESTING FOR THE 21 ST CENTURY —<br />
PRESENTED BY HEMOGENIX<br />
HALO (Hemotoxicity Assays via Luminescence Output) is a multifunctional<br />
and multiparameter testing platform that can detect and measure the effects <strong>of</strong><br />
virtually any compound on up to 14 different proliferating cell populations from<br />
5 species simultaneously from the blood-forming system. The test system is<br />
rapid, quantitative, highly sensitive and non-subjective with high-throughput<br />
capability and is ideal for all phases <strong>of</strong> drug development, from screening to<br />
monitoring the patient’s lympho-hematopoietic system during clinical trials.<br />
Tuesday Afternoon, March 8<br />
4:30 PM to 6:00 PM<br />
Room 207<br />
SOT ANNUAL BUSINESS MEETING<br />
Chairperson(s): Linda Birnbaum, SOT President<br />
SOT Members Only.<br />
Members are invited and encouraged to attend the SOT business meeting. If you<br />
have long-range planning ideas that you would like added to the agenda, please<br />
send them to Shawn Lamb at SOT Headquarters. The agenda includes a discussion<br />
<strong>of</strong> the Council 2005 Strategic Planning Session, financial summary, a<br />
review <strong>of</strong> the 2004–2005 activities, and plans for the future.<br />
TUESDAY<br />
up-to-date information at www.toxicology.org 149
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Afternoon, March 8<br />
4:30 PM to 6:00 PM<br />
Room 208<br />
Tuesday Afternoon, March 8<br />
4:30 PM to 6:00 PM<br />
Room 220<br />
TUESDAY<br />
SUNSET SESSION: IN VITRO TOXICITY TESTING OF AIR<br />
POLLUTANTS: PROS AND CONS<br />
Chairperson(s): Ian Gilmour, U.S. EPA, Research Triangle Park, NC and<br />
JeanClare Seagrave, Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
Endorsed by:<br />
In Vitro SS<br />
Inhalation SS*<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
The increasing evidence for adverse health effects resulting from acute and<br />
chronic exposure to air pollution has driven efforts to identify which components<br />
cause these effects and by what mechanisms. This, in turn, has created a<br />
need for rapid, cost-effective methods for in vitro screening and mechanistic<br />
studies. The respiratory tract is the first target <strong>of</strong> aerosols, but in vitro studies <strong>of</strong><br />
this system are complicated by species differences, varied regional anatomy and<br />
physiology, as well as the fact that aerosols interact at the gas/air inter-phase <strong>of</strong><br />
the lung surface. In addition to containing over forty different cell types that<br />
may respond quite differently to a given stimulus, host susceptibility factors that<br />
may be driven by genetics, and previous exposures may impact on observed<br />
effects. The purpose <strong>of</strong> this session is to review issues regarding the selection <strong>of</strong><br />
models, exposure methods, doses, and endpoints and to determine how these<br />
systems may reflect inhalation exposures in the exposed population.<br />
#1015 4:30 IN VITRO TOXICITY TESTING OF AIR<br />
POLLUTANTS: PROS AND CONS. M. Gilmour 1<br />
and J. Seagrave 2 . 1 NHEERL, U.S. EPA, Research<br />
Triangle Park, NC and 2 LRRI, Albuquerque, NM.<br />
#1016 4:35 CELL POPULATIONS WITHIN THE<br />
RESPIRATORY TRACT. C. G. Plopper. Anatomy,<br />
Physiology and Cell Biology, Universtiy <strong>of</strong> California,<br />
Davis, CA.<br />
#1017 4:45 SYSTEMS FOR EXPOSING LUNG CELLS TO<br />
AEROSOLS. J. Seagrave and J. D. McDonald.<br />
Lovelace Respiratory Research Institute, Albuquerque,<br />
NM.<br />
#1018 5:00 ANALYTICAL TOOLS FOR ASSESSING AIR<br />
POLLUTION TOXICITY USING DIFFERENT IN<br />
VITRO CELL CULTURE MODELS. I. Jaspers.<br />
CEMALB, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC.<br />
#1019 5:15 IN VITRO CORRELATION WITH IN VIVO<br />
EXPOSURES. R. Devlin and L. Dailey. U.S. EPA,<br />
Research Triangle Park, NC.<br />
SUNSET SESSION: TOXICOLOGY INFORMATION AND DATA<br />
UPDATE<br />
Chairperson(s): Philip Wexler, National Library <strong>of</strong> Medicine, Bethesda, MD.<br />
Endorsed by:<br />
National Capital Area Chapter<br />
As the Web and its online resources continue to expand and change rapidly,<br />
there is an increasing plethora <strong>of</strong> databases, documents, and other digital tools<br />
available to the toxicology community. Toxicologists with even formidable<br />
research skills are <strong>of</strong>ten knowledgeable about only a small fraction <strong>of</strong> what is<br />
available, and they are <strong>of</strong>ten not kept apprised <strong>of</strong> the newest developments. This<br />
symposium highlights major Web-based resources from all sectors–government,<br />
academia, industry, non-pr<strong>of</strong>its–which can benefit toxicologists in their daily<br />
research and other work. This program takes a look at a few <strong>of</strong> these resources.<br />
The National Library <strong>of</strong> Medicine’s <strong>Toxicology</strong> and Environmental Health<br />
Information <strong>Program</strong> is a major purveyor <strong>of</strong> toxicological information and data<br />
through its TOXNET system and other databases, geared to both the pr<strong>of</strong>essional<br />
and the public. The Center for Research on Environmental and<br />
Occupational <strong>Toxicology</strong> (CROET) focuses on health and safety in the workforce<br />
and supports a number <strong>of</strong> information activities, including its <strong>Toxicology</strong><br />
Information Center. The National Institute <strong>of</strong> Environmental Health Sciences<br />
(NIEHS) and the National <strong>Toxicology</strong> <strong>Program</strong> <strong>of</strong>fer a number <strong>of</strong> unique online<br />
databases and make available online numerous test reports and the Report on<br />
Carcinogens. EPA has recently unveiled its Distributed Structure Searchable<br />
Toxicity (DSS-TOX) database, another powerful tool <strong>of</strong> potential interest.<br />
#1020 4:30 TOXICOLOGY INFORMATION AND DATA<br />
UPDATE. P. Wexler. <strong>Toxicology</strong> and Environmental<br />
Health Information <strong>Program</strong>, National Library <strong>of</strong><br />
Medicine, Bethesda, MD.<br />
#1021 4:32 THE NATIONAL LIBRARY OF MEDICINE’S<br />
(NLM) WORLD LIBRARY OF TOXICOLOGY,<br />
CHEMICAL SAFETY AND ENVIRONMENTAL<br />
HEALTH. P. Wexler. <strong>Toxicology</strong> and Environmental<br />
Health Information <strong>Program</strong>, National Library <strong>of</strong><br />
Medicine, Bethesda, MD.<br />
#1022 4:47 WEB-BASED RESOURCES SPONSORED BY THE<br />
NATIONAL INSTITUTE OF ENVIRONMENTAL<br />
HEALTH SCIENCES (NIEHS) AND THE<br />
NATIONAL TOXICOLOGY PROGRAM (NTP). L.<br />
L. Wright. US Department <strong>of</strong> Health and Human<br />
Services, National Institute <strong>of</strong> Environmental Health<br />
Sciences, Research Triangle Park, NC. Sponsor: P.<br />
Wexler.<br />
#1023 5:02 THE CENTER FOR RESEARCH ON<br />
OCCUPATIONAL AND ENVIRONMENTAL<br />
TOXICOLOGY (CROET). F. Berman. Oregon Health<br />
and Science University, Portland, OR. Sponsor: P.<br />
Wexler.<br />
#1024 5:22 DSSTOX STRUCTURE-SEARCHABLE PUBLIC<br />
TOXICITY DATABASE NETWORK: CURRENT<br />
PROGRESS AND NEW INITIATIVES TO<br />
IMPROVE CHEMO-BIOINFORMATICS<br />
CAPABILITIES. A. M. Richard 1 and B. A. Rogers 1 .<br />
1 2 U.S. EPA, Research Triangle Park, NC and NCCU<br />
Student COOP, U.S. EPA, Research Triangle Park, NC.<br />
Sponsor: L. King.<br />
Abstract 1025 is located on page 129.<br />
150<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Tuesday Afternoon, March 8<br />
5:30 PM to 6:30 PM<br />
Room 216<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO4<br />
REGIONAL CHAPTER CONTACTS FOR K–12 EDUCATION<br />
MEETING<br />
Chairperson(s): Marion Miller, University <strong>of</strong> California, Davis, Davis, CA.<br />
Sponsored by:<br />
Education Committee<br />
Education Subcommittee for K–12 Education<br />
SOT Regional Chapter Contacts for K–12 Education and others interested in<br />
outreach to schools and teachers are invited to attend an informal meeting to<br />
discuss K–12 education activities at the regional level. Light refreshments will<br />
be available.<br />
Tuesday Evening<br />
Tuesday Evening, March 8<br />
6:00 PM to 7:30 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
SPECIALTY SECTION MEETINGS:<br />
BIOLOGICAL MODELING, CARCINOGENESIS, IN VITRO,<br />
INHALATION, METALS, NEUROTOXICOLOGY, REGULATORY AND<br />
SAFETY EVALUATION<br />
Tuesday Evening, March 8<br />
6:00 PM to 11:00 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
REGIONAL CHAPTER MEETINGS/RECEPTIONS<br />
Many <strong>of</strong> the Regional Chapters meet during the SOT Annual Meeting. Details<br />
for these Regional Chapter receptions and meetings are listed in <strong>Program</strong>’s<br />
Events Calendar.<br />
Wednesday Morning, March 9<br />
8:30 AM to 9:30 AM<br />
Room 215<br />
Wednesday Morning<br />
INFORMATIONAL SESSION: DEFINING MOLECULAR<br />
MECHANISMS OF TOXICITY USING AFFYMETRIX GENECHIP®<br />
ARRAYS — PRESENTED BY AFFYMETRIX<br />
Though leaders in the use <strong>of</strong> Affymetrix microarray technologies will share the<br />
techniques and strategies they have used successfully to apply GeneChip products<br />
to their research.<br />
SYMPOSIUM SESSION: BIOMARKERS OF OXIDATIVE STRESS:<br />
NEW PROSPECTS AND APPROACHES<br />
Chairperson(s): Daniel C. Liebler, Vanderbilt University, Nashville, TN and<br />
Maria Kadiiska, National Institute <strong>of</strong> Environmental Health Sciences,<br />
Research Triangle Park, NC.<br />
Endorsed by:<br />
Mechanisms SS*<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Oxidative stress plays a key role in the development <strong>of</strong> cardiovascular disease,<br />
neurodegenerative diseases, and cancer. Many toxic chemicals associated with<br />
increased risk <strong>of</strong> these diseases also induce oxidative stress. Assessment <strong>of</strong><br />
oxidative stress in clinical studies has been hampered by a dearth <strong>of</strong> robust,<br />
sensitive, and well-validated biomarkers. This symposium will address new<br />
opportunities to develop oxidative stress biomarkers for application to human<br />
clinical studies. Dr. Maria Kadiiska (NIEHS) will discuss the Biomarkers <strong>of</strong><br />
Oxidative Stress Study (BOSS), which evaluated several different noninvasive<br />
or minimally invasive chemical markers <strong>of</strong> carbon tetrachloride- or ozoneinduced<br />
oxidative stress in rats. Dr. Stanley Hazen (Cleveland Clinic<br />
Foundation) will describe the development and validation <strong>of</strong> multiplexed LC-<br />
MS-MS assays for specific lipid and protein oxidation products in human serum<br />
and the application <strong>of</strong> these markers to assess oxidative stress endpoints as risk<br />
factors for cardiovascular disease. Dr. Ian Blair (University <strong>of</strong> Pennsylvania)<br />
will present recent developments in the identification and LC-MS-MS-based<br />
analysis <strong>of</strong> products <strong>of</strong> oxidative DNA damage and DNA adducts derived from<br />
electrophilic lipid oxidation products. Dr. Lawrence Marnett (Vanderbilt<br />
University) will discuss recent findings that DNA adducts derived from electrophilic<br />
products <strong>of</strong> lipid oxidation undergo metabolism to a series <strong>of</strong> products<br />
that can be analyzed as potential urinary biomarkers <strong>of</strong> oxidative stress. Dr.<br />
Daniel Liebler (Vanderbilt University) will discuss the identification <strong>of</strong> albumin<br />
adducts formed by reactive products <strong>of</strong> lipid oxidation and the potential application<br />
<strong>of</strong> these adducts as serum biomarkers <strong>of</strong> oxidative stress in vivo.<br />
#1320 8:30 BIOMARKERS OF OXIDATIVE STRESS: NEW<br />
PROSPECTS AND APPROACHES. D. C. Liebler.<br />
Department <strong>of</strong> Biochemistry, Vanderbilt University<br />
School <strong>of</strong> Medicine, Nashville, TN.<br />
#1321 8:35 PRODUCTS OF OXIDATION AS MEASURABLE<br />
INDICATORS OF OXIDATIVE STRESS:<br />
VALIDATION OF BIOMARKERS FROM<br />
RODENT CCL4 AND OZONE EXPOSURE. M.<br />
Kadiiska. Environmental <strong>Toxicology</strong> <strong>Program</strong>, National<br />
Institute <strong>of</strong> Environmental Health Sciences, Research<br />
Triangle Park, NC. Sponsor: D. Liebler.<br />
#1322 9:10 MOLECULAR MECHANISMS OF OXIDANT<br />
STRESS IN AT-RISK SUBJECTS UNDERGOING<br />
REVASCULARIZATION. S. Hazen. Department <strong>of</strong><br />
Molecular Medicine, Cleveland Clinic Foundation,<br />
Cleveland, OH. Sponsor: D. Liebler.<br />
#1323 9:45 NOVEL BIOMARKERS OF OXIDATIVE STRESS-<br />
INDUCED DNA DAMAGE. I. Blair. Department <strong>of</strong><br />
Pharmacology, University <strong>of</strong> Pennsylvania,<br />
Philadelphia, PA. Sponsor: D. Liebler.<br />
#1324 10:20 URINARY DNA ADDUCTS AND THEIR<br />
METABOLITES AS BIOMARKERS OF<br />
OXIDATIVE STRESS. L. Marnett. Department <strong>of</strong><br />
Biochemistry, Vanderbilt University School <strong>of</strong><br />
Medicine, Nashville, TN.<br />
WEDNESDAY<br />
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#1325 10:55 PROTEIN ADDUCTS AS OXIDATIVE STRESS<br />
BIOMARKERS. D. C. Liebler. Department <strong>of</strong><br />
Biochemistry, Vanderbilt University School <strong>of</strong><br />
Medicine, Nashville, TN.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO2<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room 208<br />
SYMPOSIUM SESSION: PESTICIDE NEUROTOXICITY IN ADULTS:<br />
INTEGRATING CONTRIBUTIONS FROM EPIDEMIOLOGY AND<br />
TOXICOLOGY<br />
Chairperson(s): William Boyes, U.S. EPA, Research Triangle Park, NC.<br />
WEDNESDAY<br />
SYMPOSIUM SESSION: GENETIC SUSCEPTIBILITY AND METAL<br />
TOXICITY<br />
Chairperson(s): Ellen Silbergeld, Johns Hopkins, Baltimore, MD and Brian<br />
S. Schwartz, Johns Hopkins University School <strong>of</strong> Public Health, Baltimore,<br />
MD.<br />
Endorsed by:<br />
Metals SS*<br />
Occupational and Public Health SS<br />
Risk Assessment SS<br />
There are substantial individual differences in human susceptibilities to many<br />
toxicants, including metals. Understanding these differences in susceptibility is<br />
fundamental to identifying factors important in assessing and managing health<br />
risks associated with metals such as lead, cadmium, mercury, and arsenic.<br />
Genetic factors may play a significant role in the variable human response to<br />
metal exposures. The goal <strong>of</strong> this symposium is to present and discuss information<br />
from both epidemiology and basic research that is relevant to refining our<br />
knowledge <strong>of</strong> metal toxicity and the relationships between metal exposures and<br />
human diseases.<br />
#1326 8:30 GENETIC BASIS FOR SUSCEPTIBILITY TO<br />
METALS: METABOLISM AND MOLECULAR<br />
TARGETS. E. K. Silbergeld. Environmental Health<br />
Sciences, Johns Hopkins University Bloomberg School<br />
Public Health, Baltimore, MD.<br />
#1327 8:40 DO GENETIC POLYMORPHISMS MODIFY THE<br />
KINETICS OR TOXICITY OF LEAD? INSIGHTS<br />
FROM EPIDEMIOLOGY. B. S. Schwartz.<br />
Environmental Health Sciences, Johns Hopkins<br />
Bloomberg School <strong>of</strong> Public Health, Baltimore, MD.<br />
#1328 9:05 USE OF GENETICALLY ALTERED ANIMALS TO<br />
DETERMINE THE ROLE OF CADMIUM IN<br />
METALLOTHIONEIN TOXICITY. C. D. Klaassen.<br />
Pharmacology, U Kansas Med. Ctr, Kansas City, KS.<br />
#1329 9:30 ARSENIC METABOLISM: KNOCKOUT MICE<br />
AND POLYMORPHISM STUDIES. H. V. Aposhian,<br />
R. A. Zakharyan, U. K. Chowdhury, M. D. Avram, M.<br />
L. Wollenberg, A. Hernandez and M. M. Aposhian.<br />
Molecular and Cellular Biology, University <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
#1330 9:55 MERCURY-INDUCED AUTOIMMUNITY IN<br />
GENETICALLY SUSCEPTIBLE MICE. M.<br />
Monestier. Microbiology & Immunology, Temple<br />
University School <strong>of</strong> Medicine, Philadelphia, PA.<br />
Sponsor: E. Silbergeld.<br />
#1331 10:20 MOLECULAR MECHANISMS OF LEAD-<br />
INDUCED CARDIOVASCULAR DISEASES. E. K.<br />
Silbergeld. Environmental Health Sciences, Johns<br />
Hopkins University Bloomberg School Public Health,<br />
Baltimore, MD.<br />
Endorsed by:<br />
Neurotoxicology SS*<br />
Occupational and Public Health SS<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Neurotoxicity <strong>of</strong> high-level pesticide exposure in adults is well-documented, but<br />
less is known about the consequences <strong>of</strong> chronic exposure to moderate dose<br />
levels. Results from human epidemiology studies and animal toxicology studies<br />
are not always consistent. Recent human studies suggest that moderate pesticide<br />
exposure may be associated with increased risk <strong>of</strong> an array <strong>of</strong> neurologic symptoms,<br />
particularly affective outcomes including depression and suicide.<br />
Laboratory animal studies do not address comparable outcomes, and typically<br />
have not identified subtle neurological impairments that persist beyond the<br />
exposure period, despite higher dose levels than are typically experienced by<br />
humans. Are these apparent species differences real? If so, are they related to<br />
pharmacokinetic or pharmacodynamic factors? Alternatively, are differences<br />
related to the types <strong>of</strong> outcomes assessed, duration <strong>of</strong> exposures, combined<br />
exposures to multiple agents, or to other factors? Understanding and predicting<br />
human health risks from pesticide exposure requires complex integration <strong>of</strong> the<br />
differing data provided by human and animal studies.<br />
#1332 8:30 PESTICIDE NEUROTOXICITY AT THE<br />
INTERSECTION OF EPIDEMIOLOGY AND<br />
TOXICOLOGY. W. K. Boyes 1 and F. Kamel 2 . 1 EPA,<br />
Research Triangle Park, NC and 2 NIEHS, Research<br />
Triangle Park, NC.<br />
#1333 8:40 NEUROTOXICITY OF CHRONIC PESTICIDE<br />
EXPOSURE IN LICENSED PESTICIDE<br />
APPLICATORS IN THE AGRICULTURAL<br />
HEALTH STUDY (AHS). F. Kamel 1 , L. S. Engel 2 , B.<br />
C. Gladen 1 , J. A. Hoppin 1 , M. R. Alavanja 3 and D. P.<br />
Sandler 1 . 1 NIEHS, NIH, DHHS, Research Triangle<br />
Park, NC, 2 Memorial Sloan-Kettering Cancer Center,<br />
New York and 3 NCI, NIH, DHHS, Rockville, MD.<br />
Sponsor: W. Boyes.<br />
#1334 9:10 ORGANOPHOSPHATE EXPOSURE,<br />
DEPRESSION AND SUICIDE: MATCHING<br />
EPIDEMIOLOGICAL DATA TO MODELS BASED<br />
ON ANIMAL STUDIES AND CASE SERIES. L.<br />
London 1 , A. Flisher 2 , V. Major 3 , H. Kromhout 4 and D.<br />
Mergler 5 . 1 School <strong>of</strong> Public Health and Family<br />
Medicine, University <strong>of</strong> Cape Town, Observatory, South<br />
Africa, 2 Department <strong>of</strong> Psychiatry and Mental Health,<br />
University <strong>of</strong> Cape Town, Observatory, South Africa,<br />
3 Department <strong>of</strong> Health Sciences, Peninsula Technicon,<br />
Cape Town, South Africa, 4 Institute for Risk<br />
Assessment Sciences, Utrecht University, Utrecht,<br />
Netherlands and 5 CINBIOSE, University <strong>of</strong> Quebec a<br />
Montreal, Montreal, QC, Canada. Sponsor: W. Boyes.<br />
#1335 9:40 ANIMAL MODELS OF CHRONIC PESTICIDE<br />
TOXICITY. V. C. Moser, P. J. Bushnell, R. C.<br />
MacPhail, D. W. Herr, R. S. Marshall, D. L. Hunter and<br />
W. K. Boyes. NTD/NHEERL/ORD, U.S. EPA, Research<br />
Triangle Park, NC.<br />
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#1336 10:10 DEVELOPMENT OF PHYSIOLOGICALLY<br />
BASED PHARMACOKINETIC AND<br />
PHARMACODYNAMIC MODELS TO<br />
DETERMINE DOSIMETRY, DYNAMIC<br />
RESPONSE, AND TO ASSESS RISK FOLLOWING<br />
EXPOSURE TO ORGANOPHOSPHORUS<br />
INSECTICIDES. C. Timchalk and T. S. Poet. Pacific<br />
Northwest National Laboratory, Richland, WA.<br />
#1337 10:40 PESTICIDE NEUROTOXICITY IN ADULTS:<br />
IMPLICATIONS FOR PESTICIDE SAFETY<br />
TESTING AND PUBLIC HEALTH. W. K. Boyes.<br />
EPA, Research Triangle Park, NC.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
WORKSHOP SESSION: CURRENT REGULATORY AND SCIENTIFIC<br />
VIEWS REGARDING CHEMICAL HAZARDS TO CHILDREN<br />
Chairperson(s): Daland Juberg, Dow AgroSciences, LLC, Indianapolis, IN<br />
and Dennis Paustenbach, ChemRisk, San Francisco, CA.<br />
Endorsed by:<br />
Ethical Legal and Social Issues SS<br />
Regulatory and Safety Evaluation SS<br />
Reproductive and Development SS<br />
Risk Assessment SS*<br />
#1341 9:30 EVALUATION OF CHILDHOOD EXPOSURES TO<br />
INDUSTRIAL CHEMICALS THROUGH VCCEP.<br />
P. R. Williams. ChemRisk, Boulder, CO. Sponsor: D.<br />
Paustenbach.<br />
#1342 10:00 EVALUATION AND PREDICTION OF<br />
DOSIMETRY IN CHILDREN: EMPIRICAL AND<br />
MECHANISTIC APPROACHES. A. M. Jarabek.<br />
U.S. EPA Visiting Scientist, CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
#1343 10:30 DIFFERENTIAL SENSITIVITY OF CHILDREN<br />
AND ADULTS TO CHEMICAL TOXICITY AND<br />
THE USE OF UNCERTAINTY FACTORS IN<br />
REGULATING RISKS. G. Charnley 3 , M. L. Dourson 1<br />
and R. Scheuplein 2 . 1 <strong>Toxicology</strong> Excellence for Risk<br />
Assessment (TERA), Cincinnati, OH, 2 Keller and<br />
Heckman, Stafford, VA and 3 HealthRisk Strategies,<br />
Washington.<br />
#1344 11:00 AN EVALUATION OF ENVIRONMENTAL<br />
HEALTH TRENDS AMONG CHILDREN BASED<br />
ON MEDICAL AND SCIENTIFIC EVIDENCE. D.<br />
A. Goldstein. A2NE, Monsanto Company, St. Louis,<br />
MO. Sponsor: P. Williams.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room 207<br />
The evaluation <strong>of</strong> the health <strong>of</strong> children, specifically the estimated risk due to<br />
environmental chemical exposures, continues to receive increasing regulatory<br />
attention. It has resulted in decision-making that has scientific, policy, and<br />
public health impacts. At the center <strong>of</strong> this discussion is whether children are<br />
uniquely susceptible and whether current regulatory approaches are protective<br />
<strong>of</strong> children. This workshop will discuss ongoing initiatives by the EPA and CDC<br />
aimed at characterizing children’s exposures and evaluating biomonitoring data.<br />
Other parameters that are influential in predicting susceptibility, namely, pharmacokinetics<br />
and pharmacodynamics, will also be addressed. The use <strong>of</strong><br />
uncertainty factors in setting environmental criteria and estimating safe doses<br />
will be discussed and a case study from the VCCEP program will be presented.<br />
A view from the medical community, frequently the first responders to questions<br />
and concerns over children’s health, will be <strong>of</strong>fered. The scientific<br />
questions about whether children are significantly more susceptible to toxicants<br />
and the current regulatory response to this concern (e.g., FQPA, testing requirements,<br />
basic research, cancer risk assessment guidelines) are the focus <strong>of</strong> this<br />
workshop. An anticipated outcome is the identification <strong>of</strong> those areas <strong>of</strong><br />
research that will give the toxicology community the opportunity to be a central<br />
figure in properly addressing this important public health question.<br />
#1338 8:30 CURRENT REGULATORY AND SCIENTIFIC<br />
VIEWS REGARDING CHEMICAL HAZARDS TO<br />
CHILDREN. D. R. Juberg 1 and D. J. Paustenbach 2 .<br />
1 Regulatory Laboratories, Dow AgroSciences,<br />
Indianapolis, IN and 2 ChemRisk, San Francisco, CA.<br />
#1339 8:40 OVERVIEW OF U.S. EPA RESEARCH<br />
ACTIVITIES AIMED AT CHARACTERIZING<br />
CHILDREN’S EXPOSURES. E. A. Cohen Hubal.<br />
U.S. EPA, Research Triangle Park, NC. Sponsor: D.<br />
Juberg.<br />
#1340 9:00 USING CDC BIOMONITORING DATA FOR<br />
ASSESSING CHILDRENS’ EXPOSURES TO<br />
ENVITONMENTAL CHEMICALS. L. L. Needham.<br />
NCEH, CDC, Atlanta, GA. Sponsor: P. Williams.<br />
WORKSHOP SESSION: TOXICOLOGIC EVALUATION OF INHALED<br />
VACCINES<br />
Chairperson(s): Matthew Reed, Lovelace Respiratory Research Instisute,<br />
Albuquerque, NM and Robert House, Dynport Vaccine Company, Frederick,<br />
MD.<br />
Endorsed by:<br />
Immunotoxicology SS<br />
Inhalation SS*<br />
Regulatory and Safety Evaluation SS<br />
Mucosal and systemic immunity stimulated by aerosolized vaccines have been<br />
recognized as effective pathways for preventative immunizations and therapies<br />
for pathogens and diseases ranging from flu (e.g., FluMist) to measles (World<br />
Health Organization) to asthma. Likewise, in the face <strong>of</strong> an ever-present risk <strong>of</strong><br />
aerosol delivery <strong>of</strong> chemical and biological agents, inhaled vaccines make sense<br />
by stimulating immunity at the portal <strong>of</strong> pathogen/ chemical entry. However,<br />
several toxicological hurdles exist for those challenged with developing or regulating<br />
vaccines, especially those designed for administration to the respiratory<br />
tract. General toxicological assessment as are required for all vaccine subtypes<br />
are necessary as well as special considerations including safety pharmacology.<br />
Adjuvant type and possible transport to the brain via the olfactory pathway are<br />
<strong>of</strong> concern as well. This symposium will bring together experts in the field <strong>of</strong><br />
inhaled therapeutics and vaccine development, to give insight into the required<br />
and perceived toxicology <strong>of</strong> aerosolized vaccines.<br />
#1345 8:30 TOXICOLOGIC EVALUATION OF INHALED<br />
VACCINES. M. Reed. <strong>Toxicology</strong>, Lovelace<br />
Respiratory Research Institute, Albuquerque, NM.<br />
#1346 8:45 AIRWAY DRUG DELIVERY OPTIONS FOR<br />
INHALED BIOLOGICS AND VACCINES. C. Leach.<br />
Preclinical Development, Lovelace Respiratory<br />
Research Institute, Albuquerque, NM.<br />
WEDNESDAY<br />
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<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1347 9:10 IMMUNOGENICITY AND SAFETY TESTING OF<br />
VACCINES: A REGULATORY PERSPECTIVE<br />
ON GENERAL REQUIREMENTS AND SPECIAL<br />
ISSUES OF THE RESPIRATORY TRACT. K. L.<br />
Hastings. Office <strong>of</strong> New Drugs, CDER, U.S. FDA,<br />
Rockville, MD.<br />
#1348 9:35 UNIQUE ISSUES ASSOCIATED WITH<br />
TOXICOLOGY ASSESSMENT OF VACCINES<br />
FOR BIOWARFARE AGENTS. R. House. Dynport<br />
Vaccine Company, Frederick, MD.<br />
#1349 10:00 WHO SPONSORED PRECLINICAL TOXICITY<br />
TESTS FOR INHALED MEASLES VACCINE. M.<br />
Papania. Centers for Disease Control and Prevention,<br />
Atlanta, GA. Sponsor: M. Reed.<br />
#1350 10:25 NONCLINICAL SAFETY EVALUATION OF TLR4<br />
AGONISTS ADMINISTERED BY NASAL SPRAY.<br />
C. M. Lynch. Nonclinical Development, Corixa<br />
Corporation, Seattle, WA. Sponsor: M. Reed.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO3<br />
WORKSHOP SESSION: TOXICOLOGICAL RESEARCH AND<br />
TESTING: BEST PRACTICES AND OPPORTUNITIES FOR<br />
LABORATORY ANIMAL REFINEMENT, REDUCTION, AND<br />
REPLACEMENT<br />
Chairperson(s): Stephen Lasley, University <strong>of</strong> Illinois College <strong>of</strong> Medicine,<br />
Peoria, IL and William Stokes, National Institute <strong>of</strong> Environmental Health<br />
Sciences, Research Triangle Park, NC.<br />
Endorsed by:<br />
Animals in Research*<br />
Risk Assessment SS<br />
In the performance <strong>of</strong> toxicology studies, whether for purposes <strong>of</strong> product safety<br />
testing or identifying mechanisms <strong>of</strong> toxicant action, it is becoming increasingly<br />
important to adopt practices and approaches that refine, reduce, and replace the<br />
numbers <strong>of</strong> laboratory animals utilized. Incorporation <strong>of</strong> best practices into<br />
studies will help ensure that animals are used in the most humane and judicious<br />
manner consistent with successful attainment <strong>of</strong> the research or testing objectives.<br />
Adoption <strong>of</strong> these practices is <strong>of</strong> timely importance because <strong>of</strong> continually<br />
increasing regulatory oversight <strong>of</strong> animal care and use, and thus consideration<br />
<strong>of</strong> these issues from different viewpoints is <strong>of</strong> broad interest to toxicologists.<br />
Best practices for regulatory testing involves careful consideration and appropriate<br />
incorporation <strong>of</strong> in vitro methods, humane endpoints, and tiered testing<br />
strategies (Stokes). Current best practices for housing and providing environmental<br />
enrichment for study animals should be consistently utilized, and factors<br />
considered that might potentially influence study outcomes (Brown). GLP<br />
requirements for pre-clinical safety studies are important factors to address, and<br />
optimal animal welfare practices consistent with compliance must be ensured<br />
(McCormack). Application <strong>of</strong> toxicogenomics to pre-clinical safety studies<br />
involving animals is an emerging concern, and potential opportunities for these<br />
methodologies to refine, reduce, and replace animal use are being developed<br />
(Schechtman). Finally, updating <strong>of</strong> European Union animal welfare laws<br />
continue to evolve, and their potential impact on harmonization <strong>of</strong> animal care<br />
programs and toxicological research is a relevant concern to multinational<br />
companies (Donovan).<br />
#1351 8:30 TOXICOLOGICAL RESEARCH AND TESTING:<br />
BEST PRACTICES AND OPPORTUNITIES FOR<br />
LABORATORY ANIMAL REFINEMENT,<br />
REDUCTION, AND REPLACEMENT. S. M. Lasley 1<br />
and W. S. Stokes 2 . 1 Department <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Illinois College <strong>of</strong> Medicine, Peoria, IL<br />
and 2 NICEATM, NIEHS/NIH/DHHS, Research<br />
Triangle Park, NC.<br />
#1352 8:35 BEST PRACTICES FOR USING HUMANE<br />
ENDPOINTS AND TIERED TESTING<br />
STRATEGIES TO REFINE, REDUCE, AND<br />
REPLACE ANIMAL USE IN TOXICOLOGICAL<br />
RESEARCH AND TESTING. W. S. Stokes.<br />
NICEATM, NIEHS/NIH/DHHS, Research Triangle<br />
Park, NC.<br />
#1353 9:05 BEST PRACTICES FOR ENVIRONMENTAL<br />
ENRICHMENT AND HOUSING FOR<br />
LABORATORY ANIMALS USED IN<br />
TOXICOLOGICAL RESEARCH AND TESTING.<br />
M. J. Brown. Charles River Laboratories, East Thetford,<br />
VT. Sponsor: S. Lasley.<br />
#1354 9:35 BALANCING ANIMAL WELFARE AND GLP<br />
COMPLIANCE IN NONCLINICAL<br />
LABORATORY SAFETY STUDIES. J. F.<br />
McCormack. Office <strong>of</strong> Regulatory Affairs, US Food and<br />
Drug Administration, Rockville, MD. Sponsor: W.<br />
stokes.<br />
#1355 10:05 APPLICATION OF TOXICOGENOMICS TO PRE-<br />
CLINICAL SAFETY TESTING: VALIDATION<br />
CONSIDERATIONS FOR POTENTIAL<br />
LABORATORY ANIMAL REFINEMENT,<br />
REDUCTION, AND REPLACEMENT. L. M.<br />
Schechtman. FDA/NCTR, Rockville, MD.<br />
#1356 10:35 REVISIONS TO EUROPEAN ANIMAL WELFARE<br />
LEGISLATION: IMPACT ON ANIMAL CARE<br />
AND TOXICOLOGY STUDIES. J. C. Donovan.<br />
BioResources, Wyeth Research, Collegeville, PA.<br />
Sponsor: S. Lasley.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room 220<br />
PLATFORM SESSION: AH RECEPTOR<br />
Chairperson(s): Mark Hahn, Woods Hole Oceanographic Institute, Woods<br />
Hole, MA and Richard Pollenz, University <strong>of</strong> South Florida, Tampa, FL.<br />
#1357 8:30 THE ROLE OF THE COOH-TERMINAL<br />
TRANSACTIVATION DOMAIN OF THE MOUSE<br />
AH RECEPTOR IN LIGAND-DEPENDENT AND<br />
INDEPENDENT DEGRADATION. R. S. Pollenz and<br />
J. Popat. Biology, University <strong>of</strong> South Florida, Tampa,<br />
FL.<br />
#1358 8:50 KINETIC STUDIES OF ARYL HYDROCARBON<br />
RECEPTOR ACTIVATION BY INDOLO[3, 2-<br />
B]CARBAZOLES, INDIGOS AND 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN IN<br />
HUMAN HEPG2 CELLS. A. Rannug 1 , S. Pettersson 1 ,<br />
L. Poellinger 2 and M. Backlund 1,2 . 1 Institute <strong>of</strong><br />
Environmental Medicine, Karolinska Institutet,<br />
Stockholm, Sweden and 2 Cell and Molecular Biology,<br />
Karolinska Institutet, Stockholm, Sweden.<br />
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#1359 9:10 DRE BINDING IS NOT REQUIRED FOR<br />
REPRESSION OF AHR SIGNALING BY AHRR. B.<br />
R. Evans 1,2 , L. L. Allan 3,4 , D. H. Sherr 3 and M. E.<br />
Hahn 1 . 1 Biology, Woods Hole Oceanographic<br />
Institution, Woods Hole, MA, 2 Biology, Boston<br />
University, Boston, MA, 3 Environmental Health, Boston<br />
University School <strong>of</strong> Public Health, Boston, MA and<br />
4 Microbiology, Boston University School <strong>of</strong> Medicine,<br />
Boston, MA.<br />
#1360 9:30 ERK KINASE ACTIVITY CONTRIBUTES TO AH<br />
RECEPTOR TARGETED PROTEIN<br />
DEGRADATION AND TRANSCRIPTIONAL<br />
POTENTIAL. S. CHEN and R. H. Tukey. Laboratory<br />
<strong>of</strong> Environmental <strong>Toxicology</strong>, Departments <strong>of</strong><br />
Chemistry & Biochemistry and Pharmacology,<br />
University <strong>of</strong> California, San Diego, La Jolla, CA.<br />
#1361 9:50 INVOLVEMENT OF KINASE SIGNALING<br />
PATHWAYS IN AH-RECEPTOR MEDIATED<br />
GENE EXPRESSION IN RAT LIVER CELLS. B. V.<br />
Madhukar 1 , G. Chen 1 , C. Sorrentino 2 and M. S.<br />
Denison 2 . 1 Pediatrics/Human Development, Michigan<br />
State University, East Lansing, MI and 2 Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California at Davis, Davis,<br />
CA.<br />
#1362 10:10 ACTIVATION OF THE ARYL HYDROCARBON<br />
RECEPTOR ALTERS IN VIVO HEPATOCYTE<br />
PROLIFERATION. K. A. Mitchell 1 , S. A. Hattenbach 2<br />
and C. J. Elferink 1 . 1 Department <strong>of</strong> Pharmacology and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Texas Medical Branch,<br />
Galveston, TX and 2 UTMB Summer Undergraduate<br />
Research <strong>Program</strong>, University <strong>of</strong> Houston-Downtown,<br />
Houston, TX.<br />
#1363 10:30 TEMPORAL AND DOSE-DEPENDENT HEPATIC<br />
GENE EXPRESSION PATTERNS IN MICE<br />
PROVIDE NEW INSIGHTS INTO TCDD-<br />
MEDIATED HEPATOTOXICITY. D. R. Boverh<strong>of</strong>, L.<br />
D. Burgoon, C. Tashiro, B. Chittim, J. R. Harkema and<br />
T. R. Zacharewski. Biochemistry & Molecular Biology,<br />
National Food Safety & <strong>Toxicology</strong> Center, and Center<br />
for Integrative <strong>Toxicology</strong>, Michigan State University,<br />
East Lansing, MI.<br />
#1364 10:50 EXPRESSION OF DOMINANT NEGATIVE N-<br />
CADHERIN RESULTS IN AHR-DEPENDENT<br />
GENE INDUCTION IN HEPA 1C1C7 WILD-TYPE<br />
CELLS. L. M. Van Pay 1 and B. Allen-H<strong>of</strong>fmann 1,2 .<br />
1 Molecular and Environmental <strong>Toxicology</strong>, University<br />
<strong>of</strong> Wisconsin, Madison, WI and 2 Pathology and<br />
Laboratory Medicine, University <strong>of</strong> Wisconsin,<br />
Madison, WI.<br />
#1365 11:10 ERα IS A LIGAND-DEPENDENT MODULATOR<br />
OF AHR TRANSCRIPTION: INTERPLAY<br />
BETWEEN THE TWO RECEPTOR SYSTEMS. J.<br />
Matthews, B. Whilen and J. Gustafsson. Department <strong>of</strong><br />
Biosciences, Karolinska Institute, Huddinge, Sweden.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO1<br />
PLATFORM SESSION: FEMALE AND MALE REPRODUCTIVE<br />
SYSTEMS<br />
Chairperson(s): Kimberly Miller, University <strong>of</strong> Maryland, Baltimore, MD and<br />
Wendy Jefferson, NIEHS, Research Triangle Park, NC.<br />
#1366 8:30 THERAPEUTIC CONCENTRATIONS OF<br />
HALOPERIDOL DO NOT DIRECTLY AFFECT<br />
OVARIAN FUNCTION AND OOCYTE QUALITY<br />
AS TESTED IN MOUSE OVARIAN FOLLICLE<br />
CULTURE MODEL. R. Cortvrindt 1,2 , E. Gobbers 1 , V.<br />
Van Merris 1 and J. Smitz 1 . 1 EggCentris NV, Zellik,<br />
Belgium and 2 Follicle Biology Laboratory, Vrije<br />
Universiteit Brussel, Brussels, Belgium. Sponsor: G.<br />
Daston.<br />
#1367 8:50 BCL-2 FAMILY MEMBERS PROTECT AGAINST<br />
METHOXYCHLOR-INDUCED TOXICITY OF<br />
MOUSE OVARIAN ANTRAL FOLLICLES IN<br />
VITRO. K. P. Miller 1 , C. Greenfeld 2 and J. A. Flaws 1 .<br />
1 <strong>Program</strong> in <strong>Toxicology</strong>, University <strong>of</strong> Maryland-School<br />
<strong>of</strong> Medicine, Baltimore, MD and 2 Department <strong>of</strong><br />
Physiology, University <strong>of</strong> Maryland-School <strong>of</strong><br />
Medicine, Baltimore, MD.<br />
#1368 9:10 REVERSAL OF BENZO-A-PYRENE EFFECTS<br />
ON OXYTOCIN-INDUCED CA 2+<br />
OSCILLATIONS IN HUMAN MYOMETRIAL<br />
PHM1-41 CELLS. R. Barhoumi, I. Awooda, S. Safe<br />
and R. C. Burghardt. Faculty <strong>of</strong> <strong>Toxicology</strong>, Texas<br />
A&M University, College Station, TX.<br />
#1369 9:30 EFFECTS OF ATRAZINE AND AN ATRAZINE<br />
METABOLITE MIXTURE ON DIFFERENTIATED<br />
MAMMARY EPITHELIAL CELL MILK<br />
PROTEIN PRODUCTION IN CULTURE. E. P.<br />
Hines, R. Barbee, M. Blanton, M. S. Pooler and S. E.<br />
Fenton. Reproductive <strong>Toxicology</strong> Division, U.S. EPA,<br />
ORD, NHEERL, Research Triangle Park, NC.<br />
#1370 9:50 NEONATAL EXPOSURE TO THE<br />
PHYTOESTROGEN GENISTEIN ALTERS<br />
REPRODUCTION IN FEMALE CD-1 MICE. W.<br />
Jefferson 1,2 , E. Padilla-Bank 1 and R. Newbold 1 .<br />
1 Laboratory <strong>of</strong> Molecular <strong>Toxicology</strong>, NIEHS,<br />
NIH/DHHS, Research Triangle Park, NC and<br />
2 Molecular and Environmental <strong>Toxicology</strong> Department,<br />
North Carolina State University, Raleigh, NC.<br />
#1371 10:10 ESTROGEN-INDUCED PATTERN OF GENE<br />
EXPRESSION AT HIGH AND LOW DOSES IN<br />
FETAL MALE RAT TESTIS. J. M. Naciff, K. M.<br />
Hess, J. E. Maritnez, G. J. Overmann, L. M. Foertsch,<br />
S. M. Torontali, G. J. Carr, J. P. Tiesman and G. P.<br />
Daston. Procter & Gamble Company, Cincinnati, OH.<br />
#1372 10:30 LOW DOSE CELLULAR RESPONSES IN THE<br />
FETAL RAT TESTIS IN UTERO EXPOSED TO DI<br />
(N-BUTYL) PHTHALATE. E. Kleymenova, C.<br />
Swanson and K. W. Gaido. CIIT CHR, Research<br />
Triangle Park, NC.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 155
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1373 10:50 IDENTIFYING CANDIDATES FOR THE CDM<br />
GENE, WHICH CONFERS RESISTANCE TO<br />
CADMIUM-INDUCED TESTICULAR DAMAGE<br />
IN MICE. L. Martin 1 , H. Allayee 2 , D. Shih 3 , G. Lee 1 ,<br />
D. Hovland 4 , R. Hess 5 , K. Carnes 5 , R. M. Cantor 3,6 , A.<br />
J. Lusis 3 and M. Collins 1 . 1 Molecular <strong>Toxicology</strong>,<br />
UCLA, LA, CA, 2 Institute for Genetic Medicine, USC,<br />
LA, CA, 3 Human Genetics, UCLA, LA, CA,<br />
4 5 <strong>Toxicology</strong>, Amgen, Thousand Oaks, CA, Veterinary<br />
Biosciences, University <strong>of</strong> Illinois, Urbana, IL and<br />
6 Pediatrics, UCLA, LA, CA. Sponsor: O. Hankinson.<br />
#1374 11:10 PERIPUBERTAL DEHP EXPOSURE INHIBITS<br />
ANDROGEN-DEPENDENT DEVELOPMENT IN<br />
SPRAGUE-DAWLEY RATS. N. Noriega, J. Furr, C.<br />
Lambright, V. S. Wilson and L. E. Gray. RTD, U.S. EPA<br />
ORD NHEERL, Research Triangle Park, NC.<br />
Wednesday Morning, March 9<br />
8:30 AM to 11:30 AM<br />
Room RO6<br />
2 GeneGo, Inc., St. Joseph, MI.<br />
#1379<br />
#1380<br />
#1381<br />
#1382<br />
#1383<br />
9:50<br />
10:10<br />
10:30<br />
10:50<br />
11:10<br />
PREDICTION OF HEPATOCARCINOGENICITY<br />
OF CHEMICALS USING THE GENE<br />
EXPRESSION IN THE 28-DAY REPEAT-DOSE<br />
TOXICITY STUDY. H. Matsumoto 1 , F. Saito 1 , Y.<br />
Yoshikuni 1 , Y. Sudo 1 , M. Otsuka 1 , H. Miyaura 1 , I.<br />
Fukuda 5 , K. Saito 2 , K. Sumida 2 , M. Sekijima 3 , K.<br />
Nakayama 3 and T. Shirai 4 . 1 Chemicals Evaluation and<br />
Research Institute, Japan, Tokyo, Japan, 2 Sumitomo<br />
Chemical Co., Ltd.,, Osaka, Japan, 3 Mitsubishi<br />
Chemical Safety Institute Ltd.,, Ibaraki, Japan,<br />
4 Graduate School <strong>of</strong> Medical Sciences, Nagoya City<br />
University, Nagoya, Japan and 5 Mitsui Knowledge<br />
Industry Co., Ltd.,, Tokyo, Japan.<br />
TOXICOGENOMICS FOCUSING ON THE<br />
HEMOPOIETIC STEM CELL TOXICOLOGY. Y.<br />
Hirabayashi 1 , B. Yoon 1 , K. Kitada 2 , T. Matsushita 1,3 , K.<br />
Kobayashi 2 , K. Igarashi 1 , Y. Kodama 1 , J. Kanno 1 and T.<br />
Inoue 4 . 1 Division <strong>of</strong> Cellular & Molecular <strong>Toxicology</strong>,<br />
National Institute <strong>of</strong> Health Sciences, Tokyo, Japan,<br />
2 Kamakura Research Labs, Chugai Pharmaceutical, Co.,<br />
Ltd.,, Kamakura, Japan, 3 Fuji Gotenba Research Labs,<br />
Chugai Pharmaceutical, Co., Ltd.,, Shizuoka, Japan and<br />
4 Center for Biological Safety & Research, National<br />
Institute <strong>of</strong> Health Sciences, Tokyo, Japan.<br />
QC METRICS AND THRESHOLDS FOR<br />
ASSESSING THE OVERALL QUALITY OF A<br />
MICROARRAY STUDY. L. Shi 1 , W. Tong 1 , F.<br />
Goodsaid 2 , F. Frueh 2 , F. C. Fuscoe 1 and D. A.<br />
Casciano 3 . 1 Division <strong>of</strong> Systems <strong>Toxicology</strong>, NCTR,<br />
U.S. FDA, Jefferson, AR, 2 Office <strong>of</strong> Clinical<br />
Pharmacology and Biopharmaceutics, CDER, U.S.<br />
FDA, Rockville, MD and 3 Office <strong>of</strong> the Director,<br />
NCTR, U.S. FDA, Jefferson, AR.<br />
PROTOCOLS FOR THE ASSURANCE OF<br />
MICROARRAY DATA QUALITY AND PROCESS<br />
CONTROL. L. D. Burgoon 1,5,6 , J. E. Eckel-Passow 3 ,<br />
C. Gennings 4 , D. R. Boverh<strong>of</strong> 2,5,6 , J. W. Burt 2,5,6 , C. J.<br />
Fong 2,5,6 and T. R. Zacharewski 2,5,6 . 1 Pharmacology &<br />
<strong>Toxicology</strong>, Michigan State University, East Lansing,<br />
MI, 2 Biochemistry & Molecular Biology, Michigan<br />
State University, East Lansing, MI, 3 Health Sciences<br />
Research, Mayo Clinic Cancer Center, Rochester, MN,<br />
4 Biostatistics, Virginia Commonwealth University,<br />
Richmond, VA, 5 National Food Safety and <strong>Toxicology</strong><br />
Center, Michigan State University, East Lansing, MI<br />
and 6 Center for Integrative <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI.<br />
DBZACH: A COMPREHENSIVE<br />
TOXICOGENOMIC INFORMATION<br />
MANAGEMENT AND KNOWLEDGE<br />
DISCOVERY SYSTEM. R. Aiyar 2,3,4 , L. D.<br />
Burgoon 1,3,4 , P. C. Boutros 2,3,4 , E. Dere 2,3,4 , S.<br />
Doran 2,3,4 , S. S. Pai 2,3,4 , J. Vakharia 2,3,4 , R. Rotman 2,3,4 ,<br />
A. Adams 2,3,4 , B. Lau 2,3,4 , R. Patel 2,3,4 and T. R.<br />
Zacharewski 2,3,4 . 1 Pharmacology & <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI,<br />
2 Biochemistry & Molecular Biology, Michigan State<br />
University, East Lansing, MI, 3 National Food Safety &<br />
<strong>Toxicology</strong> Center, Michigan State University, East<br />
Lansing, MI and 4 Center for Integrative <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI.<br />
PLATFORM SESSION: TOXICOGENOMICS: ROLE IN<br />
PREDICTIVE TOXICOLOGY AND CARCINOGENICITY<br />
Chairperson(s): Alema Galijativic, Merck &Co., Inc., West Point, PA and<br />
Supratim Choudhary, U.S. FDA, College Park, MD.<br />
#1375 8:30 GENE ONTOLOGY MAPPING OF EARLY<br />
TRANSCRIPTIONAL RESPONSES ASSOCIATED<br />
WITH HEPATOCYTE PROLIFERATION IN THE<br />
LIVER OF DIETHYLHEXYLPHTHALATE-<br />
EXPOSED MICE. R. Currie 1 , V. Bombail 1 , D. J.<br />
Moore 1 , F. Lim 1 , J. Oliver 1 , K. Chipman 2 , I. Kimber 1 ,<br />
G. Orphanides 1 and J. Moggs 1 . 1 Syngenta CTL,<br />
Macclesfield, Cheshire, United Kingdom and<br />
2 University <strong>of</strong> Birmingham, Birmingham, United<br />
Kingdom.<br />
#1376 8:50 COMPARATIVE ANALYSIS OF GENE<br />
NETWORKS AT MULTIPLE DOSES AND TIME<br />
POINTS IN LIVERS OF RATS EXPOSED TO<br />
ACETAMINOPHEN. H. Sone 1,2 , H. Toyoshiba 1,2 , T.<br />
Yamanaka 1 , F. Parham 1 , R. Irwin 1 , G. Boorman 1 and C.<br />
J. Portier 1 . 1 ETP, NIEHS, Research Triangle Park, NC<br />
and 2 Environmental Health Sciences Division, NIES,<br />
Tsukuba, Ibaraki, Japan.<br />
#1377 9:10 A SIGNATURE GENE NETWORK APPROACH<br />
TO TOXICITY. S. Ekins 1 , C. Giroux 2 , Y. Nikolsky 1 ,<br />
A. Bugrim 1 and T. Nikoskaya 1 . 1 GeneGo Inc., St<br />
Joseph, MI and 2 Institute <strong>of</strong> Environmental Health<br />
Sciences, Wayne State University, Detroit, MI.<br />
#1378 9:30 A GENETIC NETWORK APPROACH TO<br />
COMPARATIVE TOXICOGENOMICS AND RISK<br />
ASSESSMENT: THE OXIDATIVE STRESS<br />
RESPONSE. C. N. Giroux 1 , S. Ekins 2 , J. Fan 1 , I.<br />
Abdullah 1 , Y. Nikolsky 2 , A. Bugrim 2 and T.<br />
Nikolskaya 2 . 1 Institute <strong>of</strong> Environmental Health<br />
Sciences, Wayne State University, Detroit, MI and<br />
156<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: FOOD SAFETY AND NUTRITION<br />
TOXICOLOGY I<br />
Chairperson(s): Debasis Bagchi, Interhealth Research Center, Benicia, CA<br />
and Kulbir Bakshi, National Research Council, Washington, DC.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1384 LEVAMISOLE RESIDUES IN CHICKEN TISSUES<br />
AND EGGS. H. El-Kholy and B. W. Kemppainen.<br />
Anatomy, Physiology, Pharmacology, Auburn<br />
University, Auburn, AL.<br />
#1385 FUMONISIN B-GLUCOSE REACTION<br />
PRODUCTS ARE LESS TOXIC WHEN FED TO<br />
SWINE. G. E. Fernandez 1 , G. D. Osweiler 1 , P. A.<br />
Murphy 1 , M. Yaeger 1 , G. Rottinghaus 2 , S. Hendrich 1<br />
and L. Buckley 1 . 1 <strong>Toxicology</strong>, Iowa State University,<br />
Ames, IA and 2 Veterinary Diagnostic Lab., University<br />
<strong>of</strong> Missouri, Columbia, MO.<br />
#1386 THE NATIONAL RESIDUE PROGRAM AS A<br />
FOOD SAFETY TOOL. J. Vodela 1 , P. Zervos 2 , C.<br />
Deyrup 3 , R. Sutton 4 , M. O’Keefe 5 , D. Pagan-<br />
Rodriguez 6 and H. Walker 7 . 1 Residue Branch,<br />
USDA/FSIS, Washington, DC, 2 Residue Branch,<br />
USDA, Washington, DC, 3 Residue Branch, USDA,<br />
Washington, DC, 4 Residue Branch, USDA, Washington,<br />
DC, 5 Residue Branch, USDA, Washington, DC,<br />
6 7 Residue Branch, USDA, Washington, DC and Residue<br />
Branch, USDA, Washington, DC.<br />
#1387 ASSESSMENT OF METALS CONCENTRATIONS<br />
IN SALMONBERRIES AND SOURDOCK<br />
COLLECTED NEAR A MINING TRANSPORT<br />
ROAD IN NORTHWEST ALASKA. M. Garry 1,2 , S.<br />
S. Shock 2 , L. J. Yost 2 , J. Kulas 3 and W. J. Shields 2 . 1 U<br />
<strong>of</strong> Wash., Seattle, WA, 2 Exponent, Bellevue, WA and<br />
3 Teck Cominco, Anchorage, AK.<br />
#1388 LACK OF EFFECTS OF BETA-CAROTENE<br />
DERIVED FROM BLAKESLEA TRISPORA, A<br />
NATURAL FOOD COLOR, IN A THIRTEEN-<br />
WEEK ORAL TOXICITY STUDY IN F344 RATS.<br />
K. Nabae 1 , T. Ichihara 1,2 , A. Hagiwara 1 , M. Kawabe 1 ,<br />
M. Nishino 3 , T. Ogasawara 3 , Y. Sasaki 3 , M. Nakamura 3<br />
and T. Shirai 2 . 1 Daiyu-Kai Institute <strong>of</strong> Medical Science,<br />
Inc., Ichinomiya, Japan, 2 Department <strong>of</strong> Experimental<br />
Pathology and Tumor Biology, Nagoya City University<br />
Graduate School <strong>of</strong> Medical Sciences, Nagoya, Japan<br />
and 3 San-Ei Gen F.F.I., Inc., Toyonaka, Japan.<br />
#1389 DEPLETION OF T CELLS BY MONOCLONAL<br />
ANTIBODIES AGAINST MTHY-1.2 ANTIGEN<br />
REDUCES FUMONISIN B 1 TOXICITY IN MICE.<br />
N. Sharma, Q. He and R. P. Sharma. Physiology and<br />
Pharmacology, university <strong>of</strong> Georgia, athens, GA.<br />
#1390 SAFETY EVALUATION OF A NEW ANTI-<br />
STALING AMYLASE ENZYME FOR BAKERY<br />
APPLICATIONS. Q. Q. Bui 1 , H. V. Thygesen 2 , L. S.<br />
Bollen 3 , Z. El-Salanti 3 and C. N. Edwards 3 . 1 Genencor<br />
International, Palo Alto, CA, 2 Danisco A/S,<br />
Copenhagen, Denmark and 3 Scantox A/S, Lille<br />
Skensved, Denmark.<br />
#1391 TIME- AND DOSE-DEPENDENT CHANGES IN<br />
SPHINGOID BASE 1 PHOSPHATES IN TISSUES<br />
FROM RATS FED DIETS CONTAINING<br />
FUMONISINS. R. T. Riley, J. L. Showker and K. A.<br />
Voss. <strong>Toxicology</strong> and Mycotoxin Research Unit, USDA-<br />
ARS, Athens, GA.<br />
#1392 TOXICOLOGY STUDIES ON ALLANBLACKIA<br />
SEED OIL. L. J. Lea and S. O’Hagan. Safety and<br />
Environmental Assurance Centre, Unilever, Bedford,<br />
United Kingdom. Sponsor: P. Hepburn.<br />
#1393 SAFETY AND EFFICACY POTENTIAL OF A<br />
NOVEL ANTHOCYANIN-RICH MULTIPLE<br />
BERRY EXTRACT IN IN VIVO MODELS. M.<br />
Bagchi 1 , D. Bagchi 1,2 and C. Sen 3 . 1 InterHealth<br />
Research Center, Benicia, CA, 2 Creighton Medical<br />
Center, Omaha, NE and 3 , Ohio State Medical Center,<br />
Columbus, OH.<br />
#1394 A 90-DAY DIETARY TOXICITY STUDY OF<br />
HEATED DAG OIL AND HEATED TG OIL IN<br />
RATS. C. P. Chengelis 1 , J. B. Kirkpatrick 1 , W. B.<br />
Lawrence 1 , O. Morita 2 , Y. Tamaki 2 and H. Suzuki 2 .<br />
1 WIL Research Laboratories, Inc., Ashland, OH and<br />
2 Kao Corporation, Haga Tochigi, Japan.<br />
#1395 ACCUMULATION OF SPHINGOID BASES AND<br />
SPHINGOID BASE 1-PHOSPHATES: A<br />
POSSIBLE MECHANISM FOR FUSARIUM<br />
VERTICILLIOIDES CORN-SEEDLING DISEASE.<br />
L. D. Williams 1,2 , A. E. Glenn 2 , C. W. Bacon 2 , M. A.<br />
Smith 1 and R. T. Riley 2 . 1 Environmental Health<br />
Sciences, UGA, Athens, GA and 2 TMRU, USDA,<br />
Athens, GA.<br />
#1396 DEVELOPMENTAL TOXICITY OF DIETS<br />
CONTAINING FUMONISIN B 1 TO LM/BC AND<br />
CD1 MICE: A COMPARATIVE STUDY. K. A.<br />
Voss 1 , J. B. Gelineau-van Waes 2 , R. T. Riley 1 , T. D.<br />
Burns 3 and C. W. Bacon 1 . 1 <strong>Toxicology</strong> & Mycotoxin<br />
Research Unit, USDA-Agricultural Research Service,<br />
Athens, GA, 2 Genetics, Cell Biology and Anatomy,<br />
University <strong>of</strong> Nebraska Medical Center, Omaha, NE and<br />
3 Interdisciplinary <strong>Program</strong> in <strong>Toxicology</strong>, University <strong>of</strong><br />
Georgia, Athens, GA.<br />
#1397 A 90-DAY DIETARY STUDY ON CARRAGEENAN<br />
WITH EMPHASIS ON THE<br />
GASTROINTESTINAL TRACT. D. C. Nuber 1 , M. L.<br />
Weiner 1 , W. Blakemore 1 , J. F. Harriman 2 and S. M.<br />
Cohen 3 . 1 <strong>Toxicology</strong>, FMC Corporation, Princeton, NJ,<br />
2 <strong>Toxicology</strong>, WIL Research Laboratories, Ashland, OH<br />
and 3 University <strong>of</strong> Nebraska Medical Center, Omaha,<br />
NE.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 157
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1398 TANNIC ACID IS A PROOXIDANT AND<br />
INDUCES CYCLOOXYGENASE-2 IN HUMAN<br />
COLON CELLS. J. P. Gray 1,2 , V. Mishin 1 , D. E.<br />
Heck 1,2 and J. D. Laskin 2,3 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, Rutgers University, Piscataway, NJ, 2 Joint<br />
Graduate <strong>Program</strong> in <strong>Toxicology</strong>, Rutgers University,<br />
Piscataway, NJ and 3 Environmental & Occupational<br />
Medicine, UMDNJ–Robert Wood Johnson Medical<br />
School, Piscataway, NJ.<br />
#1399 GENOTOXICITY STUDIES ON DIETARY<br />
DIACYLGLYCEROL (DAG) OIL. T. Kasamatsu 1 , R.<br />
Ogura 1 , N. Ikeda 1 , O. Morita 1 , K. Saigo 2 , H. Watabe 3 ,<br />
Y. Saito 3 and H. Suzuki 1 . 1 Safety and Environmental<br />
Research Section, Kao Corporation, Ichikai, Haga,<br />
TOCHIGI, Japan, 2 Shin Nippon Biochemical<br />
Laboratories, Ltd.,, Miyanoura, Yoshida,<br />
KAGOSHIMA, Japan and 3 Mitsubishi Chemical Safety<br />
Institute, Ltd.,, Hasaki, Kashima, IBARAKI, Japan.<br />
Sponsor: C. Chengelis.<br />
#1400 ISOTHERMAL MODELS FOR THE<br />
PREDICTION OF NUTRIENT INTERACTIONS<br />
WITH MYCOTOXIN SORBENTS. J. F. Taylor, E.<br />
Afriyie-Gyawu, H. J. Huebner and T. D. Phillips.<br />
Faculty <strong>of</strong> <strong>Toxicology</strong>, Texas A&M University, College<br />
Station, TX.<br />
#1401 EFFECTS OF A LOW-CARBOHYDRATE DIET<br />
ON MARKERS OF OXIDATIVE STRESS IN<br />
TISSUES FROM DIABETIC AND NON-DIABETIC<br />
RATS. J. B. Watkins, Z. T. Kamuren, D. F. O’Neill and<br />
R. A. Sanders. Medical Sciences, Indiana University<br />
School <strong>of</strong> Medicine, Bloomington, IN.<br />
#1402 CHRONIC TOXICOLOGICAL EVALUATION OF<br />
NOVASIL CLAY IN THE DIET OF SPRAGUE-<br />
DAWLEY RATS. E. Afriyie-Gyawu 1,2 , J. Mackie 3 , B.<br />
Dash 1,2 , M. C. Wiles 2 , J. Taylor 1,2 , H. J. Huebner 1,2 , H.<br />
Guan 4 , T. Lili 4 , J. Wang 4 and T. D. Phillips 1,2 . 1 Faculty<br />
<strong>of</strong> <strong>Toxicology</strong>, Texas A&M University, College Station,<br />
TX, 2 Veterinary Integrative Biosciences, Texas A&M<br />
University, College Station, TX, 3 Veterinary<br />
Pathobiology, Texas A&M University, College Station,<br />
TX and 4 Texas Tech University, Lubbock, TX.<br />
#1403 ACRYLAMIDE, HEAVY METAL COMBINATION<br />
TOXICITY AND GLUTATHIONE DEPLETION. C.<br />
Siegers 1 , M. M. Schulze 1 and J. B. Schulze 2 . 1 Institute<br />
<strong>of</strong> Experimental and Clinical Pharmacology and<br />
<strong>Toxicology</strong>, Luebeck, Germany and 2 Office <strong>of</strong> the<br />
Dean, Medical Faculty, Frankfurt, Germany.<br />
#1404 SAFETY ASSESSMENT OF LYSINE MAIZE. B.<br />
Hammond, T. Reynolds, J. Kronenberg and K. Glenn.<br />
Monsanto Company, St. Louis, MO.<br />
#1405 EVALUATION OF THE SUBCHRONIC<br />
TOXICITY OF 1507XNK603 TRANSGENIC<br />
MAIZE. S. A. MacKenzie 1 , C. Pavely 2 , L. A. Malley 1 ,<br />
N. E. Everds 1 , G. P. Sykes 1 , B. Delaney 1 and I. Lamb 2 .<br />
1 DuPont Haskell Laboratory for Health and<br />
Environmental Sciences, Newark, DE and 2 Pioneer Hi-<br />
Bred International, Inc., Johnston, IL.<br />
#1406 INDUCTION OF COLON TUMORS IN C57BL/6J<br />
MICE FED MEIQX, IQ OR PHIP FOLLOWED BY<br />
DEXTRAN SULFATE SODIUM TREATMENT. A.<br />
Nishikawa, T. Imazawa, Y. Kuroiwa, K. Kanki, Y. Ishii,<br />
Y. Kitamura, T. Umemura and M. Hirose. Pathology,<br />
National Institute <strong>of</strong> Health Sciences, Tokyo, Japan.<br />
Sponsor: M. Ema.<br />
#1407 INHIBITION OF AFB 1 ACTIVATION AND AFB 1 -<br />
DNA ADDUCT FORMATION BY DIETARY<br />
BUTYLATED HYDROXYTOLUENE IN<br />
TURKEYS. J. A. Guarisco, J. O. Hall and R. A.<br />
Coulombe. <strong>Toxicology</strong> Graduate <strong>Program</strong>, Utah State<br />
University, Logan, UT.<br />
#1408 SAFETY ASSESSMENT AND RISK/BENEFIT<br />
ANALYSIS OF THE USE OF<br />
AZODICARBONAMIDE IN BABY FOOD JAR<br />
CLOSURE TECHNOLOGY: PUTTING TRACE<br />
LEVELS OF SEMICARBAZIDE EXPOSURE<br />
INTO PERSPECTIVE. V. M. Lee-Brotherton, B. S.<br />
Lynch, K. Musa-Veloso, G. H. Goodfellow, E. Cheng, L.<br />
A. Haighton and E. R. Nestmann. CANTOX Health<br />
Science Intl., Mississauga, ON, Canada.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NATURAL PRODUCTS<br />
Chairperson(s): Sidney Stohs, AdvoCare International LP, Carrollton, TX.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1409 INHIBITORY EFFECTS OF PLATYCODON<br />
GRANDIFLORUM ON 4-<br />
(METHYLINITROSAMINO)-1-(3-PYRIDYL)-1-<br />
BUTANONE (NNK)-INDUCED LUNG<br />
TUMORIGENESIS IN A/J MICE. S. Roh 4 , D.<br />
Shin 1,2 , K. Lee 1 , Y. Chung 3 , C. Choi 3 , Y. Cho 4 and H.<br />
Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea, 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea,<br />
3 Division <strong>of</strong> Food Science, Chinju International<br />
University, Chinju, South Korea and 4 Department <strong>of</strong><br />
R&D, Jangsaeng Doraji Co., Ltd.,, Chinju, South Korea.<br />
#1410 FOUR WEEKS EXPOSURE TO A NOVEL<br />
NUTRITIONAL MIXTURE CONTAINING A<br />
SERIES OF POLYPHENOLIC<br />
PHYTOCHEMICALS ANTAGONIZES<br />
ACETAMINOPHEN-INDUCED<br />
HEPATOTOXICITY IN VIVO. S. Stohs 1 , A. Nagori 2 ,<br />
A. Naqvi 2 , N. Shah 2 and S. D. Ray 2 . 1 Res & Dev,<br />
AdvoCare International, Carrollton, TX and 2 Mol.<br />
<strong>Toxicology</strong>. Prog, Division <strong>of</strong> Pharmacology Scs., Long<br />
Island University, Brooklyn, NY.<br />
158<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1411 IN VITRO EFFICACY OF PLANT-EXTRACTS<br />
USED FOR ALTERNATIVE TREATMENT OF<br />
SNAKEBITES IN NIGERIA. I. U. Asuzu 1 , A.<br />
Harvey 2 and H. M. Lantum 3 . 1 Department <strong>of</strong> Veterinary<br />
Physiol. & Pharmacology, University <strong>of</strong> Nigeria<br />
Nsukka, Enugu, Nigeria, 2 Department <strong>of</strong> Physiol. &<br />
Pharmacology, University <strong>of</strong> Strathclyde, Glasgow,<br />
United Kingdom and 3 African <strong>Society</strong> for Toxicological<br />
Sciences (ASTS), Rochester, NY.<br />
#1412 IMMUNOMODULATING AND ANTIOXIDANT<br />
EFFECTS OF MEXICAN STRAINS OF<br />
LENTINUS LEPIDEUS, GANODERMA<br />
APPLANATUM AND ARMILLARIA TABESCENS.<br />
X. S. Ramirez-Garcia 1 , L. Garza-Ocanas 1 , F. Garza-<br />
Ocanas 2 , Y. Alcaraz-Contreras 1 and M. Salinas-<br />
Carmona 3 . 1 Farmacologia Y Toxicologia, Fac de<br />
Medicina, UANL, Monterrey, Neuvo Leon, Mexico,<br />
2 Silvicultura, Fac de Ciencias Forestales, UANL,<br />
Monterrey, Nuevo Leon, Mexico and 3 Inmunologia, Fac<br />
de Medicina, UANL, Monterrey, Nuevo Leon, Mexico.<br />
#1413 NUCLEAR TRANSLOCATION OF NF-KB/REL<br />
COMPONENT BY PCSC22 ISOLATED FROM<br />
PORIA COCOS SCLEROTIUM. Y. J. Jeon.<br />
Pharmacology, Chosun University, Kwangju, South<br />
Korea. Sponsor: H. Kim.<br />
#1414 SAFETY AND TOXICOLOGICAL EVALUATION<br />
OF A NOVEL NIACIN-BOUND CHROMIUM. M.<br />
Shara 1 , T. Yasmin 1 , M. Bagchi 2 , A. Chatterjee 1 , H. G.<br />
Preuss 3 and D. Bagchi 2 . 1 Pharmacy Science, Creighton<br />
University, Omaha, NE, 2 Research Center, InterHealth<br />
USA, Benicia, CA and 3 Medical Center, Georgetown<br />
University, Washington, DC.<br />
#1415 INHIBITORY EFFECTS OF KAHWEOL AND<br />
CAFESTOL ON CARRAGEENAN-INDUCED<br />
INFLAMMATION IN MOUSE AIR POUCH<br />
MODEL. H. Jeong 1,2 , J. Kim 1,2 and K. Jung 1,2 .<br />
1 Pharmacy, Chosun University, Kwangju, South Korea<br />
and 2 Research Center for Proteineous Materials, Chosun<br />
University, Kwangju, South Korea.<br />
#1416 UP-REGULATION OF CYCLOOXYGENASE-2<br />
EXPRESSION BY CHICKEN OVALBUMIN IN<br />
MURINE MACROPHAGES. K. Jung 1,2 , J. Kim 1,2<br />
and H. Jeong 1,2 . 1 Pharmacy, Chosun University,<br />
Kwangju, South Korea and 2 Research Center for<br />
Proteineous Materials, Chosun University, Kwangju,<br />
South Korea.<br />
#1417 ANTIOXIDATIVE EFFECTS OF PAECILOMYCES<br />
TENUIPES ON CARBON TETRACHLORIDE-<br />
INDUCED HEPATOTOXICITY IN PRIMARY<br />
CULTURES OF ADULT RAT HEPATOCYTES<br />
AND IN VIVO. I. Jun 1 , S. Hyun 1 , J. Lee 2 , T. Jeon 1 , S.<br />
Lee 1 , C. Jin 1 , D. Lee 1 , G. Kim 1 and T. Jeong 1 .<br />
1 College <strong>of</strong> Pharmacy, Yeungnam University, Kyungsan,<br />
South Korea and 2 College <strong>of</strong> Natural Resources,<br />
Yeungnam University, Kyungsan, South Korea.<br />
#1418 NATURAL PRODUCTS DISCOVERY THROUGH<br />
DEVELOPMENT THE CHALLENGES AND THE<br />
OPPORTUNITIES. C. B. Spainhour and J. Fogleman.<br />
Calvert Laboratories, Olyphant, PA.<br />
#1419 PRO-APOPTOTIC EFFECTS OF THE TROPICAL<br />
GINGER COMPOUND, 1′-ACETOXYCHAVICOL<br />
ACETATE, ON HUMAN BREAST CANCER<br />
CELLS IN VITRO. H. E. Kleiner 1,2 and C. T.<br />
Campbell 1 . 1 Pharmacology, Louisiana State University-<br />
Health Sciences Center, Shreveport, LA and 2 Feist-<br />
Weiller Cancer Center, Louisiana State University-<br />
Health Sciences Center, Shreveport, LA.<br />
#1420 NOTOGINSENG ATTENUATES LPS-INDUCED<br />
PRO-INFLAMMATORY MEDIATORS IN<br />
ANTIGEN PRESENTING CELLS. A. Rhule 1 , S.<br />
Navarro 2 , J. Smith 1 and D. M. Shepherd 1,2 . 1 Ctr for<br />
Environ Health Sciences, University <strong>of</strong> Montana,<br />
Missoula, MT and 2 Biomed Pharmacology Sciences,<br />
University <strong>of</strong> Montana, Missoula, MT.<br />
#1421 EFFECTS OF MURINE CYP1A1 IN MOUSE<br />
HEPATOMA HEPA-1C1C7 CELLS BY CATECHIN<br />
AND 3′, 4′, 3, 5, 7-O-METHYLATED CATECHIN.<br />
E. Han 1,2 , J. Kim 1,2 , H. Kim 1,2 , Y. Hwang 1,2 , T. Jeong 3 ,<br />
E. Lee 3 and H. Jeong 1,2 . 1 Pharmacy, Chosun University,<br />
Kwangju, South Korea, 2 Research Center for<br />
Proteineous Materials, Chosun University, Kwangju,<br />
South Korea and 3 Pharmacy, Yeungnam University,<br />
Kyungsan, South Korea.<br />
#1422 SUPPRESSION OF MURINE CYP1A1 IN MOUSE<br />
HEPATOMA HEPA-1C1C7 CELLS BY<br />
FORMONONETIN. E. Hann 1,2 , J. Kim 1,2 and H.<br />
Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea and 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea.<br />
#1423 CAFFEIC ACID PHENETHYL ESTER<br />
SUPPRESSED IN B16F10 MELANOMA CELL<br />
METASTASIS. D. Shin 1,2 and H. Jeong 1,2 . 1 Pharmacy,<br />
Chosun University, Kwangju, South Korea and<br />
2 Research Center for Proteineous Materials, Chosun<br />
University, Kwangju, South Korea.<br />
#1424 SUPPRESSIVE EFFECT OF GAMMA-<br />
TOCOPHEROL ON PROSTATE CANCER<br />
DEVELOPMENT IN PB/SV40 T ANTIGEN<br />
TRANSGENIC RATS. S. Sugiura 1 , S. Takahashi 1 , T.<br />
Murasaki 1 , M. M. Said 1 , S. Suzuki 1 , K. Abe 2 , M.<br />
Asamoto 1 and T. Shirai 1 . 1 Department <strong>of</strong> Experimental<br />
Pathology and Tumor Biology, Nagoya City University<br />
Graduate School <strong>of</strong> Medical Sciences, Nagoya, Japan<br />
and 2 Eisai Co., Ltd., Tokyo, Japan.<br />
#1425 SUBCHRONIC GAVAGE TOXICITY STUDY OF<br />
GINKGO BILOBA EXTRACT IN FISCHER 344<br />
RATS AND B6C3F 1 MICE. L. M. Fomby 1 , M.<br />
Hejtmancik 1 , M. J. Ryan 1 , C. Colleton 1 , D. Orzech 2 and<br />
P. Chan 2 . 1 Battelle, Columbus, OH and 2 NIEHS,<br />
Research Triangle Park, NC.<br />
#1426 INHIBITORY EFFECT OF KAHWEOL AND<br />
CAFESTOL ON TGF-BETA-INDUCED FIBROSIS<br />
IN HEPATIC STELLATE CELLS. K. Jung 1,2 and H.<br />
Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea and 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 159
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1427 ANTI-ANGIOGENETIC EFFECTS OF<br />
CAFESTOL AND KAHWEOL ON HT-1080<br />
FIBROSARCOMA CELLS. Y. Chung 3 , D. Shin 1,2 , K.<br />
Oh 1,2 , E. Woo 1,2 , C. Choi 3 , D. Kim 4 and H. Jeong 1,2 .<br />
1 Pharmacy, Chosun University, Kwangju, South Korea,<br />
2 Research Center for Proteineous Materials, Chosun<br />
University, Kwangju, South Korea, 3 Division <strong>of</strong> Food<br />
Science, Chinju International University, Chinju, South<br />
Korea and 4 Pathology, College <strong>of</strong> Oriental Medicine,<br />
Daejeon University, Daejeon, South Korea.<br />
#1428 GREEN TEA INFUSION PREVENTS DUAL<br />
PROMOTING EFFECTS OF<br />
PENTACHLOROPHENOL, AN<br />
ENVIRONMENTAL POLLUTANT, ON HEPATO-<br />
AND CHOLANGIO-CARCINOGENESIS OF<br />
MICE INDUCED BY DIETHYLNITROSAMINE. T.<br />
Umemura 1 , R. Hasegawa 2 , K. Keita 1 , Y. Kitamura 1 , A.<br />
Nishikawa 1 and M. Hirose 1 . 1 Division <strong>of</strong> Pathology,<br />
National Institute <strong>of</strong> Health Sciences, Tokyo, Japan and<br />
2 Division <strong>of</strong> Medical Safety Science, Natonal Institute<br />
<strong>of</strong> Health Sciences, Tokyo, Japan.<br />
#1429 TWO-GENERATION REPRODUCTION STUDY<br />
OF TEAVIGO (EPIGALLOCATECHIN<br />
GALLATE) IN RATS. R. Isbrucker 1 , J. A. Edwards 2 ,<br />
E. Wolz 2 and E. Marsden 3 . 1 Burdock Group,<br />
Washington, DC, 2 DSM Nutritional Products Ltd.,,<br />
Kaiseraugst, Switzerland and 3 MDS Pharmacology<br />
Services, L’Arbresle, France. Sponsor: J. Griffiths.<br />
#1430 SUPPRESSION OF LIPOPOLYSACCHARIDE-<br />
ACTIVATED CYCLOOXYGENASE-2<br />
EXPRESSION BY BIOCHANIN A IN MURINE<br />
MACROPHAGE RAW 264.7 CELLS. J. Kim 1,2 , E.<br />
Han 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University,<br />
Kwangju, South Korea and 2 Research Center for<br />
Proteineous Materials, Chosun University, Kwangju,<br />
South Korea.<br />
#1431 RUTAECARPINE IS AN AGONIST OF THE ARYL<br />
HYDROCARBON RECEPTOR. T. Jeong 3 , E. Han 1,2 ,<br />
J. Kim 1,2 , H. Kim 1,2 , Y. Hwang 1,2 , E. Lee 3 and H.<br />
Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea, 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea<br />
and 3 Pharmacy, Yeungnam University, Kyungsan, South<br />
Korea.<br />
#1432 EXPRESSION PROFILING OF ESTROGEN<br />
RESPONSIVE GENES FOR PHYTOESTROGENS<br />
BY DNA MICROARRAY ASSAY. D. Han 1 , R. Ise 1 , Y.<br />
Takahashi 2 , S. Terasaka 1 , A. Inoue 1 , M. Tanji 1 and R.<br />
Kiyama 1,3 . 1 Department R & D, InfoGenes Co., Ltd.,,<br />
Ibaraki, Japan, 2 Industrial Research Institute <strong>of</strong> Tottori<br />
Prefecture, Tottori, Japan and 3 National Institute <strong>of</strong><br />
Advanced Industrial Science and Technology, Tsukuba,<br />
Japan. Sponsor: M. Denison.<br />
#1433 MICROARRAY ANALYSIS OF T-2 TOXIN-<br />
INDUCED APOPTOTIC LESIONS OF THE<br />
LIVER, PLACENTA AND FETAL LIVER IN<br />
PREGNANT RATS. S. Sehata 1 , N. Kiyosawa 1 , F.<br />
Atsumi 1 , K. Ito 1 , T. Yamoto 1 , M. Teranishi 1 , K.<br />
Uetsuka 2 , H. Nakayama 2 and K. Doi 2 . 1 Medicinal<br />
Safety Research Laboratories, Sankyo Co., Ltd.,,<br />
Shizuoka, Japan and 2 Department <strong>of</strong> Veterinary<br />
Pathology, Graduate School <strong>of</strong> Agricultural and Life<br />
Sciences, The University <strong>of</strong> Tokyo, Tokyo, Japan.<br />
#1434 FUMONISIN B 1 ACTIVATES SERINE<br />
PALMITOYLTRANSFERASE AND<br />
SPHINGOSINE KINASE, ENZYMES<br />
IMPORTANT IN SPHINGOLIPID METABOLISM,<br />
IN MOUSE LIVER. H. Suzuki, Q. He and R. P.<br />
Sharma. The University <strong>of</strong> Georgia, Athens, GA.<br />
#1435 IN VITRO STUDIES CONFIRM SYNERGISTIC<br />
EFFECTS OF FUMONISIN B1 AND<br />
OCHRATOXIN A IN VIVO. E. E. CREPPY 1 , P.<br />
Chiarappa 2,1 , I. Baudrimont 1 , P. Borracci 2 , S. Moukha 3,1<br />
and M. CARRATU 2 . 1 <strong>Toxicology</strong>, University Bordeaux<br />
2, Bordeaux, France, 2 Pharmacology and Human<br />
Physiology, Medical School, University <strong>of</strong> Bari, Bari,<br />
Italy and 3 MycSA, INRA, Villenave d’Ornon, France.<br />
#1436 CYTOKINE GENE EXPRESSION IN RAT<br />
MICROGLIA EXPOSED TO THE MARINE<br />
TOXIN DOMOIC ACID. A. M. Mayer, M. Guzman,<br />
R. Peksa, M. L. Hall and M. J. Fay. Pharmacology,<br />
Midwestern University, Downers Grove, IL. Sponsor:<br />
W. Prozialeck.<br />
#1437 COMPARISON OF WEEKLY EXPOSURES TO<br />
ANATOXIN-A AND NICOTINE ON THE MOTOR<br />
ACTIVITY OF RATS. K. A. Jarema, J. D. Farmer and<br />
R. C. MacPhail. NHEERL, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1438 NICOTINE EFFECTS ON THE ACTIVITY OF<br />
MICE EXPOSED PRENATALLY TO THE<br />
NICOTINIC AGONIST ANATOXIN-A. R. C.<br />
MacPhail, J. D. Farmer, K. A. Jarema and N. Chern<strong>of</strong>f.<br />
NHEERL, U.S. EPA, Research Triangle Park, NC.<br />
#1439 HEAVY METAL EXPOSURE FROM HERBAL<br />
SUPPLEMENTS IN NIGERIA. O. E. Orisakwe 1 , E.<br />
Obi 1 , D. N. Akunyili 2 , B. Ekpo 3 and H. M. Lantum 4 .<br />
1 Department <strong>of</strong> Pharmacology, College <strong>of</strong> Health<br />
Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria,<br />
2 National Agency for Food and Drug Administration<br />
and Control (NAFDAC), Lagos, Nigeria, 3 Department<br />
<strong>of</strong> Biochemistry, College <strong>of</strong> Medical Sciences, Abia<br />
State University, Lagos, Nigeria and 4 African <strong>Society</strong><br />
for Toxicological Sciences (ASTS), Rochester, NY.<br />
#1440 ADDITIVE EFFECTS OF FUMONISIN B1 AND<br />
DEOXYNIVALENOL IN THE HUMAN<br />
INTESTINAL CELL LINE, CACO2. E. E.<br />
CREPPY 1 , J. H. KOUADIO 1,3 , T. M. MOBIO 1 , I.<br />
BAUDRIMONT 1 , S. MOUKHA 2 and S. D. DANO 3 .<br />
1 <strong>Toxicology</strong>, University Bordeaux 2, Bordeaux, France,<br />
2 MycSA, INRA, Villenave d’Ornon, France and<br />
3 Faculty <strong>of</strong> Pharmacy, <strong>Toxicology</strong>, University <strong>of</strong><br />
Abidjan, Abidjan, Côte d’Ivoire, France.<br />
160<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RESPIRATORY TRACT III<br />
Chairperson(s): Lee Kyeonghee, Batelle <strong>Toxicology</strong> NW, Richland, WA and<br />
James Antonini, NIOSH, Morgantown, WV.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1441 POLYNUCLEAR AROMATIC HYDROCARBONS<br />
(PAHS) FROM BUTADIENE SOOT ARE<br />
CONCENTRATED WITHIN LIPID RESERVOIRS<br />
IN HUMAN RESPIRATORY EPITHELIAL<br />
CELLS. G. Murphy, W. Henk, S. Barker and A. Penn.<br />
CBS, LSU School <strong>of</strong> Vet. Med., Baton Rouge, LA.<br />
#1442 ACTIVATION OF INFLAMMATORY<br />
MEDIATORS AND POTENTIAL ROLE OF AIR<br />
POLLUTION PARTICULATES AND AH-<br />
RECEPTOR LIGANDS IN FOAM CELL<br />
FORMATION. C. F. Vogel, E. M. Sciullo and F.<br />
Matsumura. ETOX, UC Davis, Davis, CA.<br />
#1443 PULMONARY EXPOSURE TO RESIDUAL OIL<br />
FLY ASH (ROFA) IMPAIRS SYSTEMIC<br />
MICROVASCULAR ENDOTHELIUM-<br />
DEPENDENT DILATION. T. R. Nurkiewicz 2 , M. A.<br />
Boegehold 2 , D. W. Porter 1,2 , M. Barger 1 , A. F. Hubbs 1 ,<br />
L. Millecchia 1 and V. Castranova 1,2 . 1 PPRB, NIOSH,<br />
Morgantown, WV and 2 Physiology and Pharmacology,<br />
West Virginia University, Morgantown, WV.<br />
#1444 DETECTION AND MOLECULAR ANALYSIS OF<br />
PARTICULATE AIR POLLUTION-INDUCED<br />
CARDIOPULMONARY OXIDATIVE STRESS<br />
USING A TRANSGENIC MOUSE MODEL AND<br />
EMERGING TECHNOLOGIES. K. Dreher 1 , E.<br />
Roberts 2 , S. Malstrom 3 and A. Malekafzali 4 . 1 NHEERL,<br />
U.S. EPA, Research Triangle Park, NC, 2 North Carolina<br />
State University, Raleigh, NC, 3 Xenogen Corp.,<br />
Alameda, CA and 4 Arcturus Biosciences Inc., Mountain<br />
View, CA.<br />
#1445 CONCENTRATED AMBIENT AIR POLLUTION<br />
CREATES OXIDATIVE STRESS IN CNS<br />
MICROGLIA. B. Veronesi 1 , O. Makwana 2 , M. Pooler 2 ,<br />
J. Carter 1 , J. Royland 1 and L. Chen 3 . 1 NHEERL, U.S.<br />
EPA, Research Triangle Park, NC, 2 <strong>Toxicology</strong><br />
<strong>Program</strong>, NCSU, Raleigh, NC and 3 Department <strong>of</strong><br />
Environmental Health, NYU, Tuxedo, NY.<br />
#1446 EFFECTS OF PARTICULATE MATTER ON THE<br />
PULMONARY AND VASCULAR SYSTEM: TIME<br />
COURSE IN SPONTANEOUSLY HYPERTENSIVE<br />
RATS. M. E. Gerl<strong>of</strong>s-Nijland 1 , A. F. Boere 1 , D. C.<br />
Leseman 1 , J. A. Dormans 1 , T. Sandstrom 2 , R. O.<br />
Salonen 3 , L. Van Bree 1 and F. R. Cassee 1 . 1 Centre for<br />
Environmental Health Res., Lab. for Toxicol., Pathol. &<br />
Genetics or Environmental Assesment Agency, RIVM,<br />
Bilthoven, Netherlands, 2 Respiratory Medicine and<br />
Allergy, University Hospital Umea, Umea, Sweden and<br />
3 Department Environmental Health, National Public<br />
Health Institute, Kuopio, Finland.<br />
#1447 ENDOTHELIAL INJURY IN PARTICULATE<br />
MATTER (PM)-INDUCED CARDIOVASCULAR<br />
INJURY: KINETIC ANALYSIS OF GENE<br />
EXPRESSION PROFILES. S. S. Nadadur and D. L.<br />
Costa. Pulmonary <strong>Toxicology</strong>, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1448 AIRBORNE PARTICULATE MATTER<br />
UPREGULATES INFLAMMATORY MARKERS<br />
IN THE MOUSE BRAIN: IMPLICATIONS FOR<br />
NEURODEGENERATION. A. Campbell, A. Becaria,<br />
L. Mendez, S. C. Bondy, M. Oldham and M. Kleinman.<br />
Comm. & Env. Medicine, University <strong>of</strong> CA, Irvine,<br />
Irvine, CA.<br />
#1449 SOLUBLE NICKEL ASSOCIATED WITH<br />
RESIDUAL OIL FLY ASH INCREASES<br />
SUSCEPTIBILITY TO PULMONARY INFECTION<br />
IN RATS. J. R. Roberts 1,2 , S. Young 1 , J. M. Antonini 1,2<br />
and V. Castranova 1,2 . 1 NIOSH, Morgantown, WV and<br />
2 WVU, Morgantown, WV.<br />
#1450 MEMBRANE PERMEABILITY AS A<br />
DETERMINANT OF ZN 2+ -INDUCED<br />
SIGNALING IN HUMAN AIRWAY EPITHELIAL<br />
CELLS. R. Silbajoris 1 , T. Tal 2 , D. Graff 1 , P. A.<br />
Bromberg 3 and J. M. Samet 1 . 1 Human Studies Division,<br />
NHEERL, U.S. EPA, Chapel Hill, NC, 2 Curriculum <strong>of</strong><br />
<strong>Toxicology</strong>, UNC-CH, Chapel Hill, NC and 3 CEMALB,<br />
UNC-CH, Chapel Hill, NC. Sponsor: M. Madden.<br />
#1451 ZINC CONTENT IN BALTIMORE PM 2.5 SEAS<br />
SAMPLES IS NOT SOLELY RESPONSIBLE FOR<br />
CHEMOKINE OR CYTOKINE RESPONSE IN<br />
A549 ATII CELLS OR RAW 264.7 MONOCYTES.<br />
R. J. Mitkus 3,1 , J. L. Powell 1 , J. Pancras 2 , J. M. Ondov 2<br />
and K. S. Squibb 1 . 1 Epidemiology and Preventive<br />
Medicine, University <strong>of</strong> Maryland, Baltimore, MD,<br />
2 Chemistry and Biochemistry, University <strong>of</strong> Maryland,<br />
College Park, MD and 3 Health Effects Division, Office<br />
<strong>of</strong> Pesticides Prevention, U.S. EPA, Washington, DC.<br />
#1452 EFFECT OF PULMONARY EPITHELIAL LINING<br />
FLUID ON OXIDATIVE STRESS AND DNA<br />
DAMAGE: COMPARISON AMONG ULTRAFINE<br />
PARTICLES, FERROUS SULFATE AND DIESEL<br />
PARTICLE EXTRACT. T. Cheng, Y. Cheng and Y.<br />
Lei. College <strong>of</strong> Public Health National Taiwan<br />
University, Taipei, Taiwan. Sponsor: T. Ueng.<br />
#1453 EFFECTS OF PM-ASSOCIATED METALS ON<br />
MACROPHAGE INOS AND ERK: A ROLE IN<br />
ALTERED IRON HOMEOSTASIS? C. Prophete 1 , P.<br />
Maciejczyk 1 , K. Salnikow 2 , T. Gould 3 , T. Larson 3 , P.<br />
Jaques 4 , J. Koenig 3 , C. Sioutas 5 , M. Lippmann 1 and M.<br />
Cohen 1 . 1 Environmental Medicine, New York<br />
University School <strong>of</strong> Medicine, Tuxedo, NY, 2 NCI,<br />
Bethesda, MD, 3 University <strong>of</strong> Washington, Seattle, WA,<br />
4 Clarkson University, Potsdam, NY and<br />
5 USC, Los<br />
Angeles, CA.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 161
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1454 MUTAGENICITY AND CYTOXICITY OF<br />
MANUAL METAL ARC STAINLESS STEEL<br />
WELDING FUMES (MMA-SS) BY ITS PARTICLE<br />
SIZE. I. Yu 1,2 , S. Maeng 1 , S. Kim 1 , J. Sung 1,3 , K.<br />
Chung 2 , S. Oh 2 , Y. Lee 1 and K. Kim 1 . 1 Center for<br />
Occupational <strong>Toxicology</strong>, Occupatinal Safety & Health<br />
Research Institute, KOSHA, Daejeon, South Korea,<br />
2 College <strong>of</strong> Pharmacy, Sung Kyun Kwan University,<br />
Suwon, South Korea and 3 College <strong>of</strong> Veterinary<br />
Medicine, Seoul National University, Seoul, South<br />
Korea.<br />
#1455 DNA DAMAGE IN ALVEOLAR EPITHELIAL<br />
INDUCED BY INORGANIC AND ORGANIC<br />
SOLUBLE FRACTIONS FROM MEXICO CITY<br />
URBAN AIRBORNE PARTICULATE. M. E.<br />
Gutierrez 1,2 , A. De Vizcaya-Ruiz 1 , M. Sordo 3 , P.<br />
Ostrosky 3 , D. A. Roubicek 3,4 and M. E. Cebrian 1 .<br />
1 <strong>Toxicology</strong>, CINVESTAV-IPN, Mexico City, Mexico,<br />
2 Environmental Monitoring, CIIEMAD-IPN, Mexico<br />
City, Mexico, 3 IIB-UNAM, Mexico City, Mexico and<br />
4 Mutagenesis and Cytotoxicity, CETESB, Sao Paulo,<br />
Brazil.<br />
#1456 HEALTH EFFECTS OFENVIRONMENTAL<br />
SHORT-TIME SULFUR DIOXIDE ( SO2 )<br />
EXPOSURE EMITTED FROM A VOLCANO IN<br />
MIYAKEJIMA ISLAND, SOUTH OF TOKYO. H.<br />
Uno, H. Horiguchi and F. Kayama. Division <strong>of</strong><br />
Environmental Medicine, Center for Community<br />
Medicine, Jichi Medical School, Tochigi, Japan.<br />
Sponsor: T. Yoshida.<br />
#1457 MEASUREMENT OF LUNG RESISTANCE AND<br />
COMPLIANCE FOR RESPIRATORY SAFETY<br />
PHARMACOLOGY STUDIES. S. Mason, K. Norton<br />
and H. Penton. Safety Pharmacology, CTBR Bio-<br />
Research Inc., Senneville, QC, Canada. Sponsor: C.<br />
Banks.<br />
#1458 RELATIVE ACCURACY OF BIDE AND GUYTON<br />
FORMULA FOR CALCULATING RESPIRATORY<br />
MINUTE VOLUME. K. Norton, S. Mason and A.<br />
Viau. Inhalation, CTBR Bio-Research Inc., Senneville,<br />
QC, Canada. Sponsor: C. Banks.<br />
#1459 COUGHING MODEL BY INHALATION OF<br />
CITRIC ACID IN COMMON MARMOSET<br />
(CALLITHRIX JACCHUS). K. Wako, T. Kawasuso,<br />
H. Hiratsuka, M. Takechi and M. Tsuchitani. Mitsubishi<br />
Chemical Safety Institute Ltd.,, Kashima-gun, Ibaraki,<br />
Japan.<br />
#1460 APPLICATION OF THE GUINEA PIG COUGH<br />
MODEL TO SCREEN FOR TUSSIGENIC AND<br />
ANTI-TUSSIVE PHARMACOLOGY. C. Banks, K.<br />
Norton and S. Groom. <strong>Toxicology</strong>, CTBR, Senneville,<br />
QC, Canada.<br />
#1461 MULTIDRUG RESISTANCE RELATED<br />
PROTEINS IN AIR-LIQUID INTERFACE<br />
CULTURE OF HUMAN LUNG CELLS. H. Foth, A.<br />
W. Torky, A. Raemisch and E. Stehfest. Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> Halle, Halle / Saale,<br />
Germany.<br />
#1462 AN ASSESSMENT OF THE ESTROUS CYCLES<br />
OF SPRAGUE-DAWLEY RATS RESTRAINED IN<br />
TUBES FOR NOSE-ONLY INHALATION<br />
EXPOSURE. M. Stoute, K. Robinson, A. Viau, L.<br />
Pinsonneault, M. Adamo, L. Pouliot and C. Banks.<br />
<strong>Toxicology</strong>, CTBR, Senneville, QC, Canada.<br />
#1463 IMPACT OF LOW FLOW OPERATION IN<br />
THREE NOSE-ONLY EXPOSURE SYSTEMS. O.<br />
R. Moss, A. R. James, C. U. Parkinson and B. A. Wong.<br />
Computational Biology, CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
#1464 SUPPLEMENTAL DOSING IN PRECLINICAL<br />
INHALATION STUDIES INCREASES SYSTEMIC<br />
EXPOSURES. W. Lee 1 , F. Cr<strong>of</strong>ts 2 , A. Viau 1 , M. Pino 2 ,<br />
C. Banks 1 , S. Holt 2 and T. Monticello 2 . 1 Inhalation,<br />
CTBR Bio-Research Inc., Senneville, QC, Canada and<br />
2 Drug Safety Evaluation, San<strong>of</strong>i-Aventis, Bridgewater,<br />
NJ.<br />
#1465 APPLICATION OF THE AERONEB®<br />
PROFESSIONAL NEBULISER TO INHALATION<br />
DOSING SYSTEMS FOR DOGS AND PRIMATES.<br />
G. Ian, B. Canham, N. Shepherd and P. Newham.<br />
Covance Laboratories Ltd., Harrogate, United Kingdom.<br />
Sponsor: D. Everett.<br />
#1466 PERFORMANCE OF FLOW-PAST AND<br />
CONVENTIONAL NOSE-ONLY INHALATION<br />
EXPOSURE SYSTEMS WITH POWDER AND<br />
DROPLET AEROSOLS. I. Gilkison, B. Canham, N.<br />
Shepherd and P. Newham. Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom. Sponsor: D. Everett.<br />
#1467 ANALYSIS OF UNRESTRAINED WHOLE-BODY<br />
PLETHYSMOGRAPHY (WBP) DATA BY SIGNAL<br />
PROCESSING AND MECHANISTIC MODELING.<br />
P. M. Schlosser 1 , M. Breen 2 , Z. Chen 3 , B. Ettinger 4 , A.<br />
M. Jarabek 1,5 , S. Nandi 6 , B. Tapia-Santos 7 , E.<br />
Tewksbury 1 , H. J. Trussell 8 , H. Wilson 8 and B. A.<br />
Wong 1 . 1 CIIT-CHR, Research Triangle Park, NC, 2 Case<br />
Western Reserve U, Cleveland, OH, 3 Florida State U,<br />
Tallahassee, FL, 4 U <strong>of</strong> Georgia, Athens, GA, 5 U.S. EPA,<br />
Washington, DC, 6 U <strong>of</strong> Massachusetts, Amherst, MA,<br />
7 Centro de Investigacion en Matematicas, Guanajuato,<br />
Mexico and 8 North Carolina State U, Raleigh, NC.<br />
#1468 DESIGN AND CHARACTERIZATION OF A<br />
NOVEL ROBOTIC WELDING FUME<br />
INHALATION AND EXPOSURE SYSTEM FOR<br />
LABORATORY ANIMALS. J. M. Antonini, A.<br />
Afshari, S. Stone, T. B. Chen, D. Schwegler-Berry, G.<br />
Fletcher, T. Goldsmith, K. Vandestouwe, W. McKinney,<br />
V. Castranova and D. Frazer. NIOSH, Morgantown,<br />
WV.<br />
#1469 CONCENTRATION-DEPENDENCE OF<br />
STABILITY OF AEROSOLS OF MONOMERIC<br />
DIPHENYL-METHANE-4, 4-DIISOCYANATE<br />
(MDI). J. Pauluhn. <strong>Toxicology</strong>, Bayer HealthCare,<br />
Wuppertal, Germany.<br />
162<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1470 DEVELOPMENT OF A NOVEL TRIPLE<br />
MANIFOLD NOSE-ONLY RODENT<br />
INHALATION SYSTEM: ACUTE TOXICITY OF<br />
RICIN AEROSOLS IN BALB/C MICE. C. J. Roy 1 ,<br />
N. Stahl 2 and J. M. Hartings 3 . 1 Center for<br />
Aerobiological Sciences, USAMRIID, Fort Detrick,<br />
MD, 2 Cambridge Systems, Chantilly, VA and 3 Goldbelt<br />
Raven, Frederick, MD.<br />
#1471 ESTABLISHMENT OF A BIOLOGICAL<br />
BIOASSAY FOR DETECTION OF LUNG<br />
TOXICITY DUE TO FINE PARTICLES. M.<br />
Yokohira, K. Saoo, H. Takeuchi, Y. Matsuda, Y. Zeng<br />
and K. Imaida. Pathology and Host-Defence, faculty <strong>of</strong><br />
medicine, Kagawa university, Kita-gun, kagawa, Japan.<br />
Sponsor: T. Shirai.<br />
#1472 GLASS BEAD INHALATION AND INDUCTION<br />
OF SILICOSIS. L. Beyer and B. D. Beck. Gradient<br />
Corp., Cambridge, MA.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: RISK ASSESSMENT FOR ACUTE INHALATION<br />
EXPOSURES<br />
Chairperson(s): Carol Wood, Oak Ridge National Laboratory, Oak Ridge, TN<br />
and George Alexeef, Cal/EPA, Oakland, CA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1473 DEVELOPMENT OF TOLUENE AEGLS USING<br />
PBPK MODELING IN RATS AND HUMANS. J. E.<br />
Dennison 1 , C. M. Troxel 2 and S. S. Talmage 3 . 1 CETT,<br />
Colo State U, Ft. Collins, CO, 2 CMTox, Inc., Lander,<br />
WY and 3 ORNL, Oak Ridge, TN.<br />
#1474 INTERIM ACUTE EXPOSURE GUIDELINE<br />
LEVELS (AEGLS) FOR XYLENES. C. M. Troxel 1 ,<br />
J. E. Dennison 2 and R. Benson 3 . 1 CMTox, Inc., Lander,<br />
WY, 2 CETT, Colorado State University, Fort Collins,<br />
CO and 3 U.S. EPA, Denver, CO.<br />
#1475 A REVIEW OF THE BASIS FOR HYDROGEN<br />
CHLORIDE OCCUPATIONAL EXPOSURE<br />
LIMITS. A. Havics 1 and M. P. DeLorme 2 . 1 QEPI,<br />
Indianapolis, IN and 2 DuPont Haskell Laboratory,<br />
Newark, DE.<br />
#1476 DEVELOPMENT OF ACUTE EMERGENCY<br />
GUIDELINE LEVELS (AEGLS) USING<br />
BENCHMARK DOSE (BMD) METHODOLOGY<br />
TO CALCULATE POTENTIALLY LETHAL<br />
EXPOSURES. G. V. Alexeeff, W. Tong, R. Broadwin<br />
and A. G. Salmon. OEHHA, Cal/EPA, Oakland, CA.<br />
#1477 USING ANIMAL LC50 DATA TO ESTIMATE<br />
ACUTE EXPOSURE LETHALITY THRESHOLDS<br />
FOR WORKERS. A. J. Weinrich 1 , A. Maier 2 , A.<br />
Havics 3 , B. Gadagbui 2 and M. Osier 4 . 1 Education and<br />
Information Division, US CDC-NIOSH, Cincinnati,<br />
OH, 2 <strong>Toxicology</strong> Excellence for Risk Assessment,<br />
Cincinnati, OH, 3 pH2 Environmental, Indianapolis, IN<br />
and 4 Syracuse Research Corporation, Syracuse, NY.<br />
#1478 ACUTE EXPOSURE GUIDELINE LEVELS<br />
(AEGLS) FOR NITROGEN DIOXIDE AND<br />
NITRIC OXIDE. C. S. Wood 1 and L. D. Koller 2 . 1 Oak<br />
Ridge National Laboratory, Oak Ridge, TN and 2 Loren<br />
Koller & Associates LLC, Corvallis, OR.<br />
#1479 ACUTE EXPOSURE GUIDELINE LEVELS<br />
(AEGLS) FOR NITRIC ACID. D. F. Glass 1 , C. S.<br />
Wood 1 and L. D. Koller 2 . 1 Oak Ridge National<br />
Laboratory, Oak Ridge, TN and 2 Loren Koller &<br />
Associates LLC, Corvallis, OR.<br />
#1480 INTERIM ACUTE EXPOSURE GUIDELINE<br />
LEVELS (AEGLS) FOR AMMONIA. K. A.<br />
Davidson 1 , L. A. Gephart 2 and S. D. Ripple 3 . 1 Oak<br />
Ridge National Laboratory, Oak Ridge, TN,<br />
2 ExxonMobil Chem. Europe, Machelen, Belgium and<br />
3 Dow Chem. Co., Midland, MI.<br />
#1481 EXTRAPOLATION OF LC50S TO SAFE<br />
EXPOSURE LEVELS–INSIGHTS FOR<br />
EMERGENCY RESPONDERS. M. Fay 1 , B.<br />
Luukinen 2 and J. Holler 1 . 1 <strong>Toxicology</strong>, ATSDR/CDC,<br />
Atlanta, GA and 2 Environmental Sciences and<br />
Engineering, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC. Sponsor: B. Fowler.<br />
#1482 ACUTE EXPOSURE GUIDELINE LEVELS<br />
(AEGLS) FOR HYDROGEN SULFIDE. C. Bast 1 and<br />
S. J. Barbee 2 . 1 Oak Ridge National Laboratory, Oak<br />
Ridge, TN and 2 Arch Chemicals, Inc., Norwalk, CT.<br />
#1483 MINIMAL RISK LEVELS FOR HYDROGEN<br />
SULFIDE–UPDATE. S. J. Chou 1 , M. Fay 1 , S. Keith 1<br />
and L. Ingerman 2 . 1 Division <strong>of</strong> <strong>Toxicology</strong>, Agency for<br />
Toxic Substances and Disease Registry, Atlanta, GA and<br />
2 Syracuse Research Corporation, Syracuse, NY.<br />
Sponsor: B. Fowler.<br />
#1484 ACUTE EXPOSURE GUIDELINE LEVELS<br />
(AEGLS) FOR HYDRAZINE (HZ),<br />
MONOMETHYLHYDRAZINE (MMH), AND<br />
DIMETHYLHYDRAZINE (DMH). R. Young 1 and R.<br />
Thomas 2 . 1 ORNL, Oak Ridge, TN and 2 INTERCET,<br />
Ltd.,, McLean, VA.<br />
#1485 ACUTE EXPOSURE GUIDELINE LEVELS<br />
(AEGLS) FOR 1, 1, 1, 2-TETRAFLUOROETHANE.<br />
S. S. Talmage 1 , G. Rusch 2 and H. T. Borges 1 . 1 Oak<br />
Ridge National Laboratory, Oak Ridge, TN and<br />
2 Honeywell, Morristown, NJ.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 163
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: MODULATION OF CARCINOGENESIS<br />
Chairperson(s): Howard P. Glauert, University <strong>of</strong> Kentucky, Lexington, KY<br />
and Coral Alfred Lamartiniere, University <strong>of</strong> Alabama at Birmingham,<br />
Birmingham, AL.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1486 THE THERAPEUTIC EFFECTS OF<br />
LYOPHILIZED BLACK RASPBERRIES ON<br />
NMBA-INDUCED CARCINOGENESIS. R. M. Aziz,<br />
R. Nines and G. D. Stoner. Cancer Chemoprevention<br />
and Support, The Ohio State University, Columbus, OH.<br />
#1487 EFFECTS OF DIETARY SELENIUM ON THE<br />
HEPATIC TUMOR PROMOTING ACTIVITIES<br />
OF PCBs. D. N. Stemm 1 , L. W. Robertson 3 , J. C.<br />
Tharappel 2 , B. T. Spear 4 , H. J. Lehmler 3 and H. P.<br />
Glauert 2 . 1 Graduate Center for <strong>Toxicology</strong>, University<br />
<strong>of</strong> Kentucky, Lexington, KY, 2 Graduate Center for<br />
Nutritional Sciences, University <strong>of</strong> Kentucky,<br />
Lexington, KY, 3 School <strong>of</strong> Public Health, University <strong>of</strong><br />
Iowa, Iowa and 4 Department <strong>of</strong> Microbiology and<br />
Immunology, University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1488 EFFECTS OF SELECTED DIETARY<br />
ANTIOXIDANT PHYTOCHEMICALS ON THE<br />
HEPATIC TUMOR PROMOTING ACTIVITY OF<br />
PCB-77. J. C. Tharappel 1 , D. N. Stemm 2 , R. P.<br />
Bunaciu 1 , L. W. Robertson 3 , H. J. Lehmler 3 , B. T.<br />
Spear 4 and H. P. Glauert 1 . 1 Graduate Center for<br />
Nutritional Sciences, University <strong>of</strong> Kentucky,<br />
Lexington, KY, 2 Graduate Center for <strong>Toxicology</strong>,<br />
University <strong>of</strong> Kentucky, Lexington, KY, 3 School Of<br />
Public Health, University <strong>of</strong> Iowa, Iowa and<br />
4 Department <strong>of</strong> Microbiology and Immunology,<br />
University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1489 CHANGES IN DRUG METABOLISM AS A<br />
POTENTIAL MECHANISM FOR THE<br />
SYNERGISTIC INDUCTION OF APOPTOSIS IN<br />
MDA-MB-231 CELLS BY EGCG AND 4-OH<br />
TAMOXIFEN. E. C. Stuart, J. P. Wilson, B. J. Bray<br />
and R. J. Rosengren. Pharmacology & <strong>Toxicology</strong>,<br />
Univeristy <strong>of</strong> Otago, Dunedin, New Zealand.<br />
#1490 PHYTOESTROGENS AND DIETARY FATTY<br />
ACIDS INFLUENCE SPONTANEOUS<br />
MAMMARY TUMOR DEVELOPMENT IN IN<br />
TG.NK (MMTV/C-NEU) MICE. M. Luijten 1 , A.<br />
Verhoef 1 , J. Dormans 1 , D. Beems 1 , H. Van Kranen 2 , N.<br />
Nagelkerke 2 , H. Adlercreutz 2 and A. Piersma 1 .<br />
1 National Institute for Public Health and the<br />
Environment, Bilthoven, Netherlands and 2 Folkhalsan<br />
Research Center, Helsinki, Finland. Sponsor: J. Vos.<br />
#1491 INFLUENCE OF METHOXYCHLOR EXPOSURE<br />
ON BREAST CANCER INCIDENCE IN FEMALE<br />
SPRAGUE-DAWLEY RATS. S. M. Bandiera, J. K.<br />
Tai, E. G. Hrycay and T. K. Chang. Faculty <strong>of</strong><br />
Pharmaceutical Sciences, University <strong>of</strong> British<br />
Columbia, Vancouver, BC, Canada.<br />
#1492 BREAST CANCER CHEMOPREVENTION WITH<br />
THE POLYPHENOL RESVERATROL. T. G.<br />
Whitsett and C. A. Lamartiniere. <strong>Toxicology</strong>, University<br />
<strong>of</strong> Alabama at Birmingham, Birmingham, AL.<br />
#1493 RESVERATROL ACTION ON STERIOD AND<br />
GROWTH FACTOR SIGNALING IN TRAMP<br />
MICE. C. E. Harper, B. B. Patel, J. Wang and C. A.<br />
Lamartiniere. <strong>Toxicology</strong>, University <strong>of</strong> Alabama at<br />
Birmingham, Birmingham, AL.<br />
#1494 SUPRESSION OF MMP EXPRESSION AND<br />
INVASION OF HUMAN CERVICAL CANCER<br />
CELL LINES HELA AND DOTC2 4510 BY<br />
NUTRIENTS. M. Roomi, V. Ivanov, A. Niedzwiecki<br />
and M. Rath. Cancer Division, Matthias Rath Research,<br />
Santa Clara, CA.<br />
#1495 ALTERED TRANSCRIPTIONAL REGULATION<br />
OF GENES INVOLVED IN AFLATOXIN<br />
GENOTOXICITY BY SULFORAPHANE (SFN)<br />
AND DIINDOLYLMETHANE (DIM). K. Gross-<br />
Steinmeyer 1 , P. L. Stapelton 1 , F. Liu 1 , J. H. Tracy 1 , T. K.<br />
Bammler 1 , S. C. Strom 2 and D. L. Eaton 1 . 1 Env. Occup.<br />
Health Sciences., University Washington, Seattle, WA<br />
and 2 Pathology, University Pittsburgh, Pittsburgh, PA.<br />
#1496 MICROARRAY ANALYSIS OF LPS AND NAC-<br />
INDUCED GENE EXPRESSION AND<br />
RESULTANT SYNERGISM, POTENTIATION,<br />
AND ANTAGONISM IN WEHI-231 B<br />
LYMPHOMA CELLS. K. R. Martin. Nutritional<br />
Sciences, Penn State University, University Park, PA.<br />
#1497 MODULATION OF ADULT RAT<br />
BENZO(A)PYRENE (BAP) METABOLISM AND<br />
DNA ADDUCT CONCENTRATIONS BY<br />
NEONATAL RESVERATROL (RVT) EXPOSURE.<br />
A. RAMESH. Pharmacology, Meharry Medical College,<br />
Nashville, TN.<br />
#1498 EFFECT OF DIETARY FAT ON<br />
FLUORANTHENE (FLA) METABOLISM AND<br />
DNA ADDUCT FORMATION IN F-344 RATS. S.<br />
WALKER, M. MATHIS, A. ADDAI and A. RAMESH.<br />
Pharmacology, Meharry Medical College, Nashville,<br />
TN.<br />
#1499 TRANSPLACENTAL GENOTOXICITY OF<br />
DIBENZO[A, L]PYRENE (DBP) AND THE<br />
EFFECT OF INDOLE -3-CARBINOL (I3C) IN<br />
THE MATERNAL DIET. Z. YU 1,2 , B. Mahadevan 1 ,<br />
L. K. Siddens 1,2 , D. J. Albershardt 1 , S. K. Krueger 1,2 ,<br />
M. Louderback 1 , W. M. Baird 1 and D. E. Williams 1,2,3 .<br />
1 Environmental and Molecular Toxicity, Oregon state<br />
university, corvallis, OR, 2 Linus Pauling Institute,<br />
Oregon State University, corvallis, OR and 3 Marine and<br />
Freshwater Biomedical Sciences Center, Oregon State<br />
University, corvallis, OR.<br />
#1500 STUDY OF THE INHIBITING EFFECT OF<br />
DIETARY HYDROQUINONE ON<br />
ACETYLAMINO-FLUORENE INDUCTION OF<br />
INITIATION OF RAT LIVER CARCINOGENESIS.<br />
M. J. Iatropoulos, A. M. Jeffrey, J. Duan and G. M.<br />
Williams. New York Medical College, Valhalla, NY.<br />
164<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1501 β-SITOSTEROL IN PSYLLIUM SEED HUSK<br />
RESTORES GAP JUNCTIONNAL<br />
INTERCELLULAR COMMUNICATION IN HA-<br />
RAS TRANSFECTED RAT LIVER EPITHELIAL<br />
CELLS. Y. Nakamura 1 , I. Hiroki 1 , N. Yoshikawa 1 , K.<br />
Sato 1 , K. Ohtsuki 1 , C. Chang 2 , B. L. Upham 2 and J. E.<br />
Trosko 2 . 1 Food Science, Kyoto Pref. University, Kyoto,<br />
Japan and 2 NFSTC, Michigan State University, Lansing,<br />
MI.<br />
#1502 THE EFFECTS OF CO-ADMINISTRATION OF<br />
ANTIOXIDANTS AND DIMETHYLARSINIC<br />
ACID (DMA) ON THE BLADDER EPITHELIUM<br />
OF FEMALE F344 RATS. S. M. Cohen 1 , L. L.<br />
Arnold 1 , M. Cano 1 and M. Wei 2 . 1 Path/Micro,<br />
University <strong>of</strong> Nebraska Medical Center, Omaha, NE and<br />
2 Pathology, Osaka City University Medical School,<br />
Osaka, Japan.<br />
#1503 RAPID INDUCTION OF COLORECTAL TUMORS<br />
IN RATS INITIATED WITH 1, 2-<br />
DIMETHYLHYDRAZINE FOLLOWED BY<br />
DEXTRAN SODIUM SULFATE<br />
TREATMENT–POSSIBLE APPLICATION FOR A<br />
NEW MEDIUM-TERM RAT COLON BIOASSAY.<br />
T. Imai, J. Onose, M. Hasumura, Y. Cho and M. Hirose.<br />
Division <strong>of</strong> Pathology, National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan. Sponsor: M. Ema.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CARCINOGENICITY BIOASSAYS<br />
Chairperson(s): Marie Amoruso, ExxonMobil Biomedical Sciences Inc.,<br />
Annandale, NJ and James E. Swauger, RJR Tobacco Company, Winston Salem,<br />
NC.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1504 LACK OF CARCINOGENIC EFFECTS IN F-344<br />
RATS FED BIS(2-ETHYLHEXYL)-1, 4-<br />
BENZENEDICARBOXYLATE (DEHT). L. E.<br />
Navarro 1 , K. M. Ruble 1 , J. A. Deyo 1 and R. M. David 2 .<br />
1 Eastman Chemical Company, Kingsport, TN and<br />
2 Eastman Kodak Company, Rochester, NY.<br />
#1505 DIMETHYLARSINIC ACID (DMA): RESULTS<br />
OF CHRONIC TOXICITY/ONCOGENICITY<br />
STUDIES IN FISCHER F344 RATS AND B6C3F1<br />
MICE. M. Eldan 1 , L. L. Arnold 2 , M. van Gemert 3 and<br />
S. M. Cohen 2 . 1 Luxembourg Industries (Pamol) Ltd.,,<br />
Tel-Aviv, Israel, 2 Path/Micro, University <strong>of</strong> Nebraska<br />
Medical Center, Omaha, NE and 3 Exponent,<br />
Washington, DC.<br />
#1506 GINGIVAL CARCINOGENICITY IN FEMALE<br />
HARLAN SPRAGUE-DAWLEY RATS AFTER<br />
ORAL TREATMENT FOR TWO YEARS WITH 2,<br />
3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN AND<br />
DIOXIN-LIKE COMPOUNDS. K. Yoshizawa 1 , N. J.<br />
Walker 2 , M. P. Jokinen 5 , A. E. Brix 6 , D. M. Sells 7 , T.<br />
Marsh 1 , M. E. Wyde 3 , D. Orzech 3 , J. K. Haseman 4 and<br />
A. Nyska 1 . 1 Laboratory <strong>of</strong> Experimental Pathology,<br />
NIEHS, Research Triangle Park, NC, 2 Laboratory <strong>of</strong><br />
Computational Biology and Risk Analysis, NIEHS,<br />
Research Triangle Park, NC, 3 <strong>Toxicology</strong> Operation<br />
Branch, NIEHS, Research Triangle Park, NC,<br />
4 Biostastistics Branch, NIEHS, Research Triangle Park,<br />
NC, 5 Pathology Associates–A Charles River Company,<br />
Durham, NC, 6 Experimental Pathology Laboratories,<br />
Research Triangle Park, NC and 7 Battelle Columbus<br />
Laboratories, Columbus, OH.<br />
#1507 CHRONIC TOXICITY AND ONCOGENICITY<br />
STUDY OF<br />
OCTAMETHYLCYCLOTETRASILOXANE (D4)<br />
IN FISCHER 344 RATS. K. P. Plotzke 1 , P. A. Jean 1 , J.<br />
W. Crissman 1 , K. M. Lee 2 and R. G. Meeks 1 . 1 Dow<br />
Corning Corporation, Midland, MI and 2 Battelle,<br />
Richland, WA.<br />
#1508 CHRONIC TOXICITY AND ONCOGENICITY<br />
STUDY OF HEXAMETHYLDISILOXANE<br />
(HMDS) IN FISCHER-344 RATS. M. L. Jovanovic 1 ,<br />
S. D. Cr<strong>of</strong>oot 1 , J. W. Crissman 1 , P. A. Smith 2 , K. P.<br />
Plotzke 1 and R. G. Meeks 1 . 1 Dow Corning Corporation,<br />
Midland, MI and 2 RCC Ltd., Itingen, Switzerland.<br />
#1509 CHRONIC TOXICITY AND ONCOGENICITY<br />
STUDY OF<br />
DECAMETHYLCYCLOPENTASILOXANE (D5)<br />
IN FISCHER-344 RATS. S. D. Cr<strong>of</strong>oot 1 , M. L.<br />
Jovanovic 1 , J. W. Crissman 1 , P. A. Smith 2 , K. P.<br />
Plotzke 1 and R. G. Meeks 1 . 1 Dow Corning Corporation,<br />
Midland, MI and 2 RCC Ltd., Itingen, Switzerland.<br />
#1510 CHRONIC TOXICITY AND ONCOGENICITY<br />
STUDY OF POLYDIMETHYLSILOXANE (PDMS)<br />
10 CST FLUID IN FISCHER 344 RATS. R. G.<br />
Meeks 1 , P. A. Jean 1 , J. W. Mertens 2 , K. S. Regan 3 , J. W.<br />
Crissman 1 and K. P. Plotzke 1 . 1 Dow Corning<br />
Corporation, Midland, MI, 2 WIL Research Laboratories,<br />
Ashland, OH and 3 Regan Path/<strong>Toxicology</strong> Services,<br />
Ashland, OH.<br />
#1511 HISTOGENESIS OF SPONTANEOUS LESIONS IN<br />
THE V-HA-RAS (TG.AC) MOUSE. A.<br />
HARGREAVES, M. Jacobsen, C. Sadler, S. Barrett and<br />
J. Wright. CTL Pathology, Syngenta, Macclesfield,<br />
United Kingdom. Sponsor: I. Kimber.<br />
#1512 A CARCINOGEN BIOASSAY FOR COMPLEX<br />
MIXTURES. K. LaDow 1 , D. Warshawsky 1 , R. Albert 1 ,<br />
W. Xue 1 , S. Spalding 1 , G. P. Boivin 2 , D. Ginsburg 1 and<br />
P. Succop 1 . 1 Environmental Health, University <strong>of</strong><br />
Cincinnati College <strong>of</strong> Medicine, Cincinnati, OH and<br />
2 Pathology and Laboratory Medicine, University <strong>of</strong><br />
Cincinnati College <strong>of</strong> Medicine, Cincinnati, OH.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 165
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1513 EVALUATION OF K6ODC TRANSGENIC MICE<br />
AS A DERMAL CARCINOGENICITY MODEL<br />
FOR ONCOGENIC DNA. T. J. Miller 1 , P.<br />
Espandiari 1 , R. Honchel 1 , A. D. Knapton 1 , J. Zhang 1 , F.<br />
Sistare 1 , L. Sheng 2 , A. M. Lewis 2 , K. Peden 2 and J. P.<br />
Hanig 1 . 1 CDER, U.S. FDA, Silver Spring, MD and<br />
2 CBER, U.S. FDA, Rockville, MD.<br />
#1514 DETERMINATION OF THE SKIN CANCER<br />
POTENTIAL OF PETROLEUM-DERIVED<br />
MATERIALS USING K6/ODC MICE. M. A.<br />
Amoruso 1 , G. W. Trimmer 1 , R. C. Forgash 1 , S.<br />
Gilmour 2 and J. J. Freeman 1 . 1 <strong>Toxicology</strong> &<br />
Environmental Sciences, ExxonMobil Biomedical<br />
Sciences, Inc., Annandale, NJ and 2 Lankenau Institute<br />
for Medical Research, Wynnewood, PA.<br />
#1515 COMPARATIVE 30-WEEK DERMAL TUMOR<br />
PROMOTION STUDY USING SENCAR MICE:<br />
EVALUATION OF CIGARETTE SMOKE<br />
CONDENSATE FROM A CONTROL CIGARETTE<br />
AND TEST CIGARETTES WITH TWO BANDED<br />
CIGARETTE PAPER TECHNOLOGIES. D. R.<br />
Meckley 1 , D. H. Pence 1 , K. R. Van Kampen 2 , P. H.<br />
Ayres 1 and J. E. Swauger 1 . 1 R.J. Reynolds Tobacco<br />
Company, Winston-Salem, NC and 2 The Van Kampen<br />
Group, Hoover, AL.<br />
#1516 COMPARATIVE 13-WEEK INHALATION STUDY<br />
OF MAINSTREAM CIGARETTE SMOKE FROM<br />
CIGARETTES CONTAINING CAST SHEET<br />
TOBACCO. R. Potts, D. R. Meckley, K. Shreve, P. H.<br />
Ayres, D. H. Pence, C. D. Garner, D. J. Doolittle and J.<br />
E. Swauger. Scientific & Regulatory Affairs, R. J.<br />
Reynolds Tobacco Company, Winston-Salem, NC.<br />
#1517 DIFFERENTIATING INITIATING FROM<br />
PROMOTING EFFECTS OF CIGARETTE<br />
MAINSTREAM SMOKE IN THE PRODUCTION<br />
OF LUNG TUMORS IN A MOUSE INHALATION<br />
BIOASSAY. S. F. Yee, M. Misra, J. Hamm, R.<br />
Leverette, S. Vulimiri, D. Heck and N. Rajendran.<br />
Lorillard Tobacco Company, Greensboro, NC.<br />
#1518 CIGARETTE MAINSTREAM SMOKE AND GAS<br />
PHASE-DEPLETED PARTICULATE PHASE<br />
ENHANCE LUNG TUMORIGENICITY IN A/J<br />
MOUSE. W. Stinn 1 , H. Haussmann 1 , A. Buettner 1 and<br />
J. H. Arts 2 . 1 Philip Morris Research Laboratories<br />
GmbH, Cologne, Germany and 2 TNO Nutrition and<br />
Food Research, Zeist, Netherlands.<br />
#1519 INTERSPECIES SITE CONCORDANCE FOR<br />
MAMMARY CARCINOGENESIS BY<br />
ENVIRONMENTAL TOBACCO SMOKE. A. G.<br />
Salmon, M. D. Miller and M. A. Marty. OEHHA,<br />
California EPA, Oakland, CA.<br />
#1520 DEVELOPMENT OF QUANTITATIVE QSAR<br />
MODELS TO PREDICT CANCER POTENCY OF<br />
CHEMICALS. R. Venkatapathy 1 , C. Moudgal 2 and R.<br />
Bruce 2 . 1 ORISE/NCEA-U.S. EPA, Cincinnati, OH and<br />
2 NCEA, U.S. EPA, Cincinnati, OH.<br />
#1521 CANCER RISK ESTIMATION FOR EXPOSURE<br />
TO NAPHTHALENE. S. Hoover, J. P. Brown, A. G.<br />
Salmon, M. S. Sandy, L. Zeise and M. A. Marty.<br />
OEHHA, California EPA, Oakland, CA.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NERVOUS SYSTEM: MECHANISMS OF<br />
TOXICITY<br />
Chairperson(s): Nasser H. Zawia, University <strong>of</strong> Rhode Island, Kingston, RI.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1522 PROTECTIVE EFFECT OF NRF2 ON THE<br />
MUSCLE OF MICE WITH AMYOTROPHIC<br />
LATERAL SCLEROSIS. J. C. Kern 1,2 , A. D. Kraft 1 ,<br />
A. Vermeern 1 and J. A. Johnson 1,2 . 1 Pharmaceutical<br />
Sciences, University <strong>of</strong> Wisconsin-Madison, Madison,<br />
WI and 2 Molecular and Environmental <strong>Toxicology</strong><br />
Center, University <strong>of</strong> Wisconsin-Madison, Madison, WI.<br />
#1523 SENSITIVITY TO MITOCHONDRIAL COMPLEX<br />
II INHIBITORS, MALONATE AND 3-<br />
NITROPROPIONIC ACID IN NRF2 KNOCKOUT<br />
MICE. M. Calkins 1,2 , R. J. Jakel 1,3,4 and J. A.<br />
Johnson 1,2,5 . 1 School <strong>of</strong> Pharmacy, University <strong>of</strong><br />
Wisconsin, Madison, WI, 2 Molecular and<br />
Environmental <strong>Toxicology</strong> Center, University <strong>of</strong><br />
Wisconsin, Madison, WI, 3 Neuroscience Training<br />
<strong>Program</strong>, University <strong>of</strong> Wisconsin, Madison, WI,<br />
4 Medical Scientist Training <strong>Program</strong>, University <strong>of</strong><br />
Wisconsin, Madison, WI and 5 Waisman Center,<br />
University <strong>of</strong> Wisconsin, Madison, WI.<br />
#1524 NEUROPROTECTIVE EFFECTS OF<br />
METALLOTHIONEIN-III IN MUTANT<br />
EXPANDED POLYGLUTAMINE EXPRESSED<br />
NEUROBLASTOMA CELLS. K. Lee 1 , Y. Hwang 1,2 ,<br />
K. Jung 1,2 , D. Shin 1,2 , K. Oh 1,2 , J. Choi 1,2 and H.<br />
Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea and 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea.<br />
#1525 METALLOTHIONEIN III ATTENUATES 6-<br />
HYDROXYDOPAMINE-INDUCED APOPTOTIC<br />
CELL DEATH IN SH-SY5Y CELLS. Y. Hwang 1,2<br />
and H. Jeong 1,2 . 1 Pharmacy, Chosun University,<br />
Kwangju, South Korea and 2 Research Center for<br />
Proteineous Materials, Chosun University, Kwangju,<br />
South Korea.<br />
#1526 MITOCHONDRIAL-DEPENDENT INITIATION<br />
OF APOPTOSIS AND FEEDBACK REGULATION<br />
BY PKCδ IN PROTEOSOME INHIBITOR MG-<br />
132-INDUCED DOPAMINERGIC<br />
DEGENERATION. F. Sun, A. Kanthasamy, Y. Yang, V.<br />
Anantharam and A. G. Kanthasamy. Biomedical<br />
Sciences, Iowa State University, Ames, IA.<br />
#1527 PROTEOSOME INHIBITOR ACLARUBICIN<br />
INDUCES DOPAMINERGIC CELL DEATH AND<br />
PARKINSON’S-LIKE SYMPTOMS IN MICE:<br />
IMPLICATIONS FOR UBIQUITIN-<br />
PROTEOSOME DYSFUNCTION IN<br />
PARKINSON’S DISEASE. C. Latchoumycandane, A.<br />
Vellareddy, A. Kanthasamy and A. Kanthasamy.<br />
Department <strong>of</strong> Biomedical Sciences, Iowa State<br />
University, Ames, IA.<br />
166<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1528 THROMBIN PRECONDITIONING PREVENTS<br />
STRIATAL ATROPHY AND DOPAMINERGIC<br />
TERMINAL LOSS, BUT NOT DOPAMINE<br />
DEPLETION IN A 6−HYDROXYDOPAMINE<br />
PARKINSON′S DISEASE MODEL. J. R. Cannon 1,2 ,<br />
Y. Hua 1 , G. Xi 1 and R. F. Keep 1,3 . 1 Department <strong>of</strong><br />
Neurosurgery, The University <strong>of</strong> Michigan, Ann Arbor,<br />
MI, 2 Department <strong>of</strong> Envrionmental health Sciences, The<br />
University <strong>of</strong> Michigan, Ann Arbor, MI and<br />
3 Department <strong>of</strong> Physiology, The University <strong>of</strong><br />
Michigan, Ann Arbor, MI.<br />
#1529 ROLE FOR PROTEASE-ACTIVATED<br />
RECEPTOR 1 (PAR1) IN MPTP-INDUCED<br />
DOPAMINERGIC NEUROTOXICITY. C. Hamill 1 ,<br />
M. Caudle 2 , J. R. Richardson 2 , G. W. Miller 2 and S. F.<br />
Traynelis 1 . 1 Department <strong>of</strong> Pharmacology, Emory<br />
University, Atlanta, GA and 2 Center for<br />
Neurodegenerative Disease, Emory University, Atlanta,<br />
GA.<br />
#1530 NICOTINE STIMULATION INDUCES TH<br />
MESSENGER RNA EXPRESSION AND<br />
TRANSCRIPTION RATE IN MN9D CELLS. P. M.<br />
Radcliffe 1 and A. Tank 2 . 1 <strong>Toxicology</strong>, University <strong>of</strong><br />
Rochester, Rochester, NY and<br />
2 Pharmacology/Physiology, Univer <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#1531 NEUROPROTECTION AND NEURORESCUE<br />
AGAINST BETA-AMYLOID TOXICITY BY<br />
METALLOTHIONEIN III. C. Choi 3 , Y. Hwang 1,2 , D.<br />
Oh 1,2 , D. Shin 1,2 , J. Choi 1,2 , D. Kim 4 and H. Jeong 1,2 .<br />
1 Pharmacy, Chosun University, Kwangju, South Korea,<br />
2 Research Center for Proteineous Materials, Chosun<br />
University, Kwangju, South Korea, 3 Division <strong>of</strong> Food<br />
Science, Chinju International University, Chinju, South<br />
Korea and 4 Pathology, College <strong>of</strong> Oriental Medicine,<br />
Daejeon University, Daejeon, South Korea.<br />
#1532 CHARACTERIZATION OF CEREBRAL SP1, Aβ<br />
AND APP IN RATS: AN<br />
IMMUNOHISTOCHEMICAL STUDY OF AGING<br />
AND NEURODEGENERATION. B. Brock, K.<br />
DiPalma, M. Basha and N. H. Zawia. Biomediacl and<br />
Pharmaceutical Sciences, University <strong>of</strong> Rhode Island,<br />
Kingston, RI.<br />
#1533 THE CHOROID PLEXUS EXPRESSES THE<br />
ENZYMES NECESSARY FOR BETA-AMYLOID<br />
PRODUCTION. E. L. Smith, J. S. Crossgrove and W.<br />
Zheng. School <strong>of</strong> Health Sciences, Purdue University,<br />
West Lafayette, IN.<br />
#1534 THE CHOROID PLEXUS ACCUMULATES BETA-<br />
AMYLOID FROM BRAIN CSF: IMPLICATIONS<br />
FOR ALZHEIMER’S DISEASE. J. S. Crossgrove, G.<br />
Li and W. Zheng. School <strong>of</strong> Health Sciences, Purdue<br />
University, West Lafayette, IN.<br />
#1535 DIFFERENTIAL EXPRESSION OF GRP78 AND<br />
HSP70 IN PRIMARY BRAINSTEM AND<br />
CORTICAL ASTROCYTES EXPOSED TO 1, 3-<br />
DINTROBENZENE. S. A. Runkle, S. R. Steiner and<br />
M. A. Philbert. <strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong><br />
Michigan, Ann Arbor, MI.<br />
#1536 MIXED INHIBITION OF THE PYRUVATE<br />
DEHYDROGENASE COMPLEX BY M-<br />
DINITROBENZENE. J. A. Miller and M. A. Philbert.<br />
<strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong> Michigan, Ann<br />
Arbor, MI.<br />
#1537 NITRIC OXIDE MEDIATES MITOCHONDRIAL<br />
DYSFUNCTION IN NEUROENDOCRINE<br />
TOXICITY. D. E. Heck 1,2 , J. Gray 1 , D. Osbourn 2 and<br />
P. J. Smith 2 . 1 Rutgers University, Piscataway, NJ and<br />
2 Marine Biological Laboratory, Woods Hole, MA.<br />
#1538 NITRIC OXIDE ACTIVATES P53 AND INDUCES<br />
APOPTOSIS IN NEURONAL PC12 CELLS. C.<br />
Brynczka 1,2 and A. Merrick 1 . 1 National Center For<br />
Toxicogenomics, NIEHS, Research Triangle Park, NC<br />
and 2 Environmental and Molecular <strong>Toxicology</strong>, NCSU,<br />
Raleigh, NC.<br />
#1539 EVALUATION OF THE INTERACTION<br />
BETWEEN CAVEOLIN AND GLIAL<br />
FIBRILLARY ACIDIC PROTEIN IN C6 GLIA. G.<br />
Velazquez 1 , E. E. Aquino 1 , N. Mayol 2 , H. Maldonado 2<br />
and W. I. Silva 1 . 1 Physiology, UPR Medical Sciences<br />
Campus, San Juan, Puerto Rico and 2 Pharmacology,<br />
Caribbean Central University, Bayamon, Puerto Rico.<br />
Sponsor: B. Jimenez Velez.<br />
#1540 REACTIVE GLIOSIS IN NEUROTOXIC AND<br />
MECHANICAL INJURY MODELS. C. L. Damiani,<br />
D. B. Miller and J. P. O’Callaghan. CDC-NIOSH,<br />
Morgantown, WV.<br />
#1541 ERK1/2-RSK2 STIMULATION OF MEF2C<br />
TRANSCRIPTION PROMOTES CORTICAL<br />
NEURON SURVIVAL. Y. Wang, L. Liu and Z. Xia.<br />
Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Washington, Seattle, WA.<br />
#1542 DEVELOPMENTAL LEAD EXPOSURE AFFECTS<br />
THE SURVIVAL OF GRANULE CELLS IN THE<br />
RAT HIPPOCAMPUS. T. Verina, C. A. Rohde and T.<br />
R. Guilarte. Environmental Health Sciences, Johns<br />
Hopkins University, Baltimore, MD.<br />
#1543 PPAR ALPHA ACTIVATION ENHANCES<br />
CYANIDE-INDUCED NEUROTOXICITY BY UP-<br />
REGULATION OF UCP-2. X. Zhang, L. Li, K.<br />
Prabhakaran, J. L. Borowitz and G. E. Isom. Medicinal<br />
Chemistry and Molecular Pharmacology, Purdue<br />
University, West Lafayette, IN.<br />
#1544 NEUROPROTECTION AGAINST<br />
METHAMPHETAMINE (METH) AFFORDED BY<br />
PRETREATMENT WITH INCREASING DOSES<br />
OF THE DRUG IS DEPENDENT ON THE<br />
DOSING SCHEDULE OF METH USED DURING<br />
THE DRUG CHALLENGE. D. L. Graham 1,2 , P. H.<br />
Noailles 1 , B. Ladenheim 1 , T. H. Moran 3 and J. L.<br />
Cadet 1 . 1 Molecular Neuropsychiatry Branch,<br />
DHHS/NIH/NIDA/IRP, Baltimore, MD, 2 <strong>Program</strong> in<br />
<strong>Toxicology</strong>, University <strong>of</strong> Maryland School <strong>of</strong><br />
Medicine, Baltimore, MD and 3 Department <strong>of</strong><br />
Psychiatry and Behavioral Sciences, The Johns Hopkins<br />
University School <strong>of</strong> Medicine, Baltimore, MD.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 167
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1545 SUBCHRONIC EXPOSURE TO LOW LEVELS OF<br />
POLYCHLORINATED BIPHENYLS REDUCES<br />
DOPAMINE TRANSPORTER AND VESICULAR<br />
MONOAMINE TRANSPORTER 2 LEVELS. M.<br />
Caudle, J. R. Richardson and G. W. Miller. Center for<br />
Neurodegenerative Disease, Emory University, Atlanta,<br />
GA.<br />
#1546 ACRYLAMIDE DISRUPTS UPTAKE OF<br />
DOPAMINE INTO RAT STRIATAL SYNAPTIC<br />
VESICLES. R. M. LoPachin 1 and D. S. Barber 2 .<br />
1 Anesthesiology, Albert Einstein College <strong>of</strong> Medicine,<br />
Bronx, NY and 2 Center for Environmental Health and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Florida, Gainesville, FL.<br />
#1547 INHIBITION OF HUMAN α7 NEURONAL<br />
NICOTINIC ACETYLCHOLINE RECEPTORS BY<br />
THE VOLATILE ORGANIC SOLVENT<br />
TRICHLOROETHYLENE. C. A. Meacham, A. S.<br />
Bale, P. J. Bushnell and T. J. Shafer. Neurotoxicology<br />
Division, NHEERL, ORD, U.S. EPA, Research Triangle<br />
Park, NC.<br />
#1548 XYLENE BLOCKS VOLTAGE-GATED CALCIUM<br />
CURRENTS IN PHEOCHROMOCYTOMA<br />
CELLS. T. J. Shafer. Neurotoxicology Division,<br />
NHEERL, ORD, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#1549 NEUROTOXIC (1, 2, 4-) AND NON-NEUROTOXIC<br />
(1, 3, 5-) TRIETHYLBENZENES. V. S. Palmer, D. D.<br />
Tshala-Katumbay, R. J. Kayton, P. S. Spencer and M. I.<br />
Sabri. Center for Research on Occupational and<br />
Environmental <strong>Toxicology</strong>, Oregon Health & Science<br />
University, Portland, OR.<br />
#1550 RAPID-ONSET GAMMA-DIKETONE<br />
AXONOPATHY IN HIPPOCAMPAL NEURONS IN<br />
CULTURE. D. D. Tshala-Katumbay, B. Sampo, V. S.<br />
Palmer, G. A. Banker, M. I. Sabri and P. S. Spencer.<br />
Center for Research on Occupational and<br />
Environmental <strong>Toxicology</strong>, and Department <strong>of</strong><br />
Neurology, School <strong>of</strong> Medicine, Oregon Health &<br />
Science University, Portland, OR.<br />
#1551 GAMMA-DIKETONE TOXICITY: A ROLE FOR<br />
STATHMIN IN NERVE AND TESTES DAMAGE?<br />
M. I. Sabri 1 , S. B. Hashemi 1 , S. Chohan 1 , S. Khalil 1 , A.<br />
B. Cranson 1 , D. D. Tshala-Katumbay 1 , V. S. Palmer 1 , J.<br />
G. Pounds 2 and P. S. Spencer 1 . 1 Center for Research on<br />
Occupational and Environmental <strong>Toxicology</strong>;<br />
Department <strong>of</strong> Neurology, School <strong>of</strong> Medicine, Oregon<br />
Health & Science University, Portland, OR and<br />
2 Molecular Biosciences, Pacific Northwest National<br />
Laboratory, Richland, WA.<br />
#1552 EFFECTS OF SUBACUTE AND CHRONIC<br />
ACRYLAMIDE DOSING ON FAST-<br />
TRANSPORTED PROTEINS INTO RAT<br />
NEUROMUSCULAR JUNCTIONS. D. W. Sickles<br />
and A. Testino. Cellular Biology and Anatomy, Medical<br />
College <strong>of</strong> Georgia, Augusta, GA.<br />
#1553 REDUCTIONS IN NEUROMUSCULAR<br />
JUNCTION CHOLINESTERASE ACTIVITY BY<br />
SUBACUTE AND CHRONIC ACRYLAMIDE<br />
EXPOSURE. B. Newman, L. Oblak, D. Kumiski and<br />
D. Sickles. Cellular Biology and Anatomy, Medical<br />
College <strong>of</strong> Georgia, Augusta, GA.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: BIOTRANSFORMATION/CYTOCHROME P450 II<br />
Chairperson(s): Rao Uppu, Southern University and A&M College, Baton<br />
Rouge, LA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1554 HUMAN FLAVIN-CONTAINING<br />
MONOOXYGENASE: QUANTIFICATION IN<br />
HUMAN TISSUES. J. R. Cashman and J. Zhang.<br />
Human BioMolecular Research Institute, San Diego,<br />
CA. Sponsor: D. Schlenk.<br />
#1555 OXIDATION OF SELENOMETHIONINE BY<br />
FLAVIN-CONTAINING MONOOXYGENASES<br />
(FMOS). D. Shi and D. Schlenk. Department <strong>of</strong><br />
Environmental Sciences, University <strong>of</strong> California,<br />
Riverside, CA.<br />
#1556 COMPARISON OF MAJOR PHASE I AND PHASE<br />
II METABOLISM REACTIONS IN<br />
CRYOPRESERVED CYNO MONKEY AND<br />
HUMAN HEPATOCYTES. B. R. Snodgrass 1 , P. V.<br />
Gagne 1 , P. L. Picano 1 , K. J. Lohnes 1 , S. P. Cain 2 , G. G.<br />
Zhang 1 , C. J. Patten 1 and C. L. Crespi 1 . 1 Research &<br />
Development, BD Discovery Labware, Woburn, MA<br />
and 2 Operations, BD Discovery Labware, Woburn, MA.<br />
#1557 COMPARISON OF CELLULAR MODELS FOR<br />
ASSESSING LIVER TOXICITY. R. Maitra, K.<br />
Moore, S. Frank and A. Higgins. Icoria, Inc., Research<br />
Triangle Park, NC. Sponsor: J. Hamilton.<br />
#1558 PANCREATIC AND HEPATIC ETHANOL<br />
TOXICITY IN HEPATIC ALCOHOL<br />
DEHYDROGENASE DEFICIENT DEER MICE:<br />
MORPHOLOGICAL AND BIOCHEMICAL<br />
CHARACTERIZATION. K. Bhopale 1 , H. Wu 1 , P.<br />
Boor 1 , G. A. Ansari 1 and B. S. Kaphalia 1 . 1 Pathology,<br />
University <strong>of</strong> Texas Medical Branch, Galveston, TX,<br />
2 Pathology, University <strong>of</strong> Texas Medical Branch,<br />
Galveston, TX, 3 Pathology, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX, 4 Pathology, University <strong>of</strong> Texas<br />
Medical Branch, Galveston, TX and 5 Pathology,<br />
University <strong>of</strong> Texas Medical Branch, Galveston, TX.<br />
#1559 VARIABILITY IN METABOLISM OF CHLORAL<br />
HYDRATE IN HUMAN HEPATOCYTES. A.<br />
Bronley-DeLancey 2 , D. G. Hoel 2 and D. C. McMillan 1 .<br />
1 Department <strong>of</strong> Pharmacology, Medical University <strong>of</strong><br />
South Carolina, Charleston, SC and 2 Department <strong>of</strong><br />
Biostatistics, Bioinformatics and Epidemiology, Medical<br />
University <strong>of</strong> South Carolina, Charleston, SC.<br />
#1560 TOXICOKINETIC ASPECTS OF HEPATOTOXIC<br />
INTERACTIONS BETWEEN BENZENE AND<br />
TCE. A. Freidig 1 , H. Wortelboer 1 , W. Heijne 1 , R.<br />
Stierum 1 , M. Schut 1 , D. Jonker 1 , H. El-Masri 2 , D.<br />
M<strong>of</strong>fett 2 and J. Groten 1 . 1 TNO Voeding, Zeist,<br />
Netherlands and 2 ATSDR, Atlanta, GA.<br />
168<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1561 IN VITRO AND IN VIVO KINETICS OF<br />
MIDAZOLAM IN COMMERCIALLY RAISED<br />
GAMEBIRDS. K. Cortright and A. Craigmill.<br />
Environmental <strong>Toxicology</strong>, UC Davis, Davis, CA.<br />
#1562 HEPATIC MICROSOMAL METABOLISN OF<br />
LITHOCHOLIC ACID. A. K. Deo and S. M.<br />
Bandiera. Faculty <strong>of</strong> Pharmaceutical Sciences,<br />
University <strong>of</strong> British Columbia, Vancouver, BC,<br />
Canada.<br />
#1563 IN VITRO METABOLISM OF 4-VINYLPHENOL<br />
AND STYRENE IN MOUSE, RAT AND HUMAN<br />
MICROSOMES. M. Bartels 1 , D. Rick 1 , F. Zhang 1 , E.<br />
Leibold 2 , H. Gelbke 2 and G. Cruzan 3 . 1 <strong>Toxicology</strong>,<br />
Dow Chemical, Midland, MI, 2 BASF,<br />
Aktiengesellschaft, Ludwigshafen/Rhein, Germany and<br />
3 ToxWorks, Bridgeton, NJ.<br />
#1564 COVALENT MODIFICATION OF AMINO ACID<br />
NUCLEOPHILES BY STYRENE OXIDE. W. Yuan,<br />
J. Chung and J. Zheng. Pharmaceutical Sciences,<br />
Northeastern University, Boston, MA.<br />
#1565 NITROREDUCTION OF TATTOO PIGMENT<br />
YELLOW 74 BY XANTHINE OXIDASE:<br />
FORMATION OF A DNA ADDUCT AND<br />
MUTAGENICITY OF THE NITROSO<br />
REDUCTION PRODUCT. P. C. Howard 1 , Y. Cui 1 , L.<br />
H. Couch 1 , M. I. Churchwell 1 , D. R. Doerge 1 , P. P. Fu 1 ,<br />
J. Wang 2 , T. Chen 2 , N. Mei 2 and M. M. Moore 2 .<br />
1 Division Biochemical <strong>Toxicology</strong>, NCTR, U.S. FDA,<br />
Jefferson, AR and 2 Division Genetic and Reproductive<br />
<strong>Toxicology</strong>, NCTR, U.S. FDA, Jefferson, AR.<br />
#1566 REACTIONS OF NITRIC OXIDE-DERIVED<br />
OXIDANTS WITH 4-ACETAMIDOPHENOL:<br />
FORMATION OF ELECTROPHILIC<br />
INTERMEDIATES. R. M. Uppu 1 and R. J. Martin 2 .<br />
1 Environmental <strong>Toxicology</strong>, Southern University, Baton<br />
Rouge, LA and 2 School <strong>of</strong> Human Ecology, Louisiana<br />
State University, Baton Rouge, LA.<br />
#1567 THE ROLES OF LIVER AND TARGET-TISSUE<br />
P450-MEDIATED DMBA METABOLISM IN<br />
DMBA-INDUCED DNA ADDUCT FORMATION<br />
IN THE MAMMARY GLAND. H. Cui, J. Gu, L.<br />
Zhang, Q. Zhang and X. Ding. Wadsworth Center,<br />
Albany, NY.<br />
#1568 VINCLOZOLIN IN VITRO METABOLISM BY<br />
RAT LIVER MICROSOMES. A. Sierra-Santoyo 1 , R.<br />
Harrison 2 , B. Edwards 2 , H. A. Barton 2 and M. F.<br />
Hughes 2 . 1 <strong>Toxicology</strong> Section, CINVESTAV-IPN,<br />
Mexico City, D.F., Mexico and<br />
2 NHEERL/ORD/ETD/PKB, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1569 HYDROLYTIC METABOLISM OF<br />
PYRETHROIDS BY HUMAN<br />
CARBOXYLESTERASES AND RODENT AND<br />
HUMAN LIVER MICROSOMES. M. K. Ross 1 , P. M.<br />
Potter 2 and A. Borazjani 1 . 1 Center for Environmental<br />
Health Sciences, Mississippi State University,<br />
Mississippi State, MS and 2 Mol. Pharmacology, St.<br />
Jude’s Children’s Research Hospital, Memphis, TN.<br />
#1570 METABOLISM OF ARSENICALS MAY<br />
INFLUENCE THEIR PROLIFERATIVE EFFECTS<br />
ON HUMAN CACO-2 CELLS. G. S. Bayse 1 , W. G.<br />
Kirlin 2 , A. M. Rollins-Hairston 2 and K. Jackson 1 .<br />
1 Chemistry, Spelman College, Atlanta, GA and<br />
2 Pharmacology/<strong>Toxicology</strong>, Morehouse School <strong>of</strong><br />
Medicine, Atlanta, GA.<br />
#1571 A NOVEL HALOENOL LACTONE DERIVATIVE<br />
POTENTIATES CYTOTOXICITY INDUCED BY<br />
CISPLATIN RETARDING THE GLUTATHIONE-<br />
MEDIATED DETOXIFICATION OF CISPLATIN<br />
IN HUMAN RENAL TUMOR CELL LINES. J.<br />
Zheng and W. Wang. Pharmaceutical Sciences,<br />
Northeastern University, Boston, MA.<br />
#1572 BIOACTIVATION OF 1-CHLORO-2-HYDROXY-3-<br />
BUTENE TO 1-CHLORO-3-BUTEN-2-ONE, A<br />
NOVEL CROSS-LINKING AGENT. A. A. Elfarra, R.<br />
J. Krause, X. Zhang and C. A. Klumb. Department <strong>of</strong><br />
Comparative Biosciences, University <strong>of</strong> Wisconsin,<br />
Madison, WI.<br />
#1573 4’-FLUORO SUBSTITUTION OF<br />
DESMETHYLATED ARZOXIFENE COULD<br />
DECREASE TOXICITY WHILE MAINTAINING<br />
ANTIESTROGENIC ACTIVITY. H. liu, G. R.<br />
Thatcher and J. L. Bolton. Medicinal Chemsitry and<br />
Pharmacognosy, University <strong>of</strong> Illinois at Chicago,<br />
Chicago, IL.<br />
#1574 REDUCTION OF 1-FURAN-2-YL-3-PYRIDIN-2-<br />
YL-PROPENONE, AN ANTI-INFLAMMATORY<br />
AGENT, BY CARBONYL REDUCTASE IN RAT<br />
LIVER MICROSOMES. S. Lee 1 , T. Jeon 1 , C. Jin 1 , S.<br />
Hyun 1 , G. Kim 1 , I. Jun 1 , D. Lee 1 , E. Lee 1 , Y. Jahng 1 , D.<br />
Kim 2 and T. Jeong 1 . 1 Yeungnam University, Kyungsan,<br />
South Korea and 2 Bioanalysis and Biotransformation<br />
Research Center, Seoul, South Korea.<br />
#1575 PHASE 1 AND PHASE 2 METABOLISMS OF<br />
RUTAECARPINE IN MICE AND RATS. G. Kim, D.<br />
Lee, S. Lee, T. Jeon, S. Hyun, C. Jin, I. Jun, E. Lee, Y.<br />
Jahng and T. Jeong. College <strong>of</strong> Pharmacy, Yeungnam<br />
University, Kyungsan, Kyungbuk, South Korea.<br />
#1576 METABOLIC SHIFT FOLLOWING MULTIPLE<br />
DOSES OF [14C]-1, 3-DINITROBENZENE TO<br />
RATS. J. J. Tobias and T. Miller. <strong>Toxicology</strong>,<br />
University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1577 METABOLISM OF METHACRYLONITRILE TO<br />
CYANIDE: INHIBITION BY CAFFEINE AND<br />
POTENTIATION BY ALCOHOL. M. Y. Farooqui.<br />
Biology, University <strong>of</strong> Texas Pan American, Edinburg,<br />
TX.<br />
#1578 METABOLISM OF GERANYL NITRILE AND<br />
CITRONELLYL NITRILE BY PRIMARY<br />
HEPATOCYTES FROM MICE, RATS AND<br />
HUMANS. R. A. Kemper 1 , D. L. Nabb 1 , S. A. Gannon 1 ,<br />
T. A. Snow 1 and A. Api 2 . 1 DuPont Haskell Laboratory,<br />
Newark, DE and 2 Research Institute for Fragrance<br />
Materials (RIFM), Woodcliff, NJ.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 169
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1579 KINETICS AND SCALING OF METABOLIC<br />
BIOTRANSFORMATION IN FISH: A<br />
COMPILATION OF RATE AND AFFINITY<br />
VALUES MEASURED UNDER PHYSIOLOGICAL<br />
CONDITIONS. P. N. Fitzsimmons and J. W. Nichols.<br />
U.S. EPA/ORD/NHEERL/MED, Duluth, MN.<br />
#1580 KINETICS AND SCALING OF METABOLIC<br />
BIOTRANSFORMATION IN FISH: EFFECTS ON<br />
BIOACCUMULATION PREDICTED BY<br />
INCORPORATING IN VITRO DATA INTO TWO<br />
KINETIC MODELS. J. W. Nichols and P. N.<br />
Fitzsimmons. U.S. EPA/ORD/NHEERL/MED, Duluth,<br />
MN.<br />
#1581 MECHANISMS OF INTERACTIVE<br />
DEVELOPMENTAL TOXICITY OF<br />
POLYCYCLIC AROMATIC HYDROCARBONS IN<br />
ZEBRAFISH. S. Billiard, D. Wassenberg, E. Linney<br />
and R. Di Giulio. Duke University, Durham, NC.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: ECOTOXICOLOGY<br />
Chairperson(s): Richard Di Giulio, Duke University, Durham, NC and Eva<br />
Oberdorster, Southern Methodist University, Dallas, TX.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1582 ALTERED GENE EXPRESSION AND<br />
DEVELOPMENT OF POTENTIAL BIOMARKERS<br />
IN MEDAKA (ORYZIAS LATIPES) BRAIN, LIVER,<br />
AND TESTIS FOLLOWING EXPOSURE TO<br />
FIBRATE PHARMACEUTICALS. D. C. Bencic 1,2 ,<br />
D. C. Volz 1 , P. Chen 1 , A. D. Biales 2 , J. M. Lazorchak 2 ,<br />
D. E. Hinton 1 and S. W. Kullman 1 . 1 Integrated<br />
<strong>Toxicology</strong> <strong>Program</strong> and Nicholas School <strong>of</strong> the<br />
Environment and Earth Sciences, Duke University,<br />
Durham, NC and 2 Molecular Ecology Research Branch,<br />
EERD, NERL, ORD, U.S. EPA, Cincinnati, OH.<br />
#1583 A CROSS-SPECIES APPROACH TO USING<br />
GENOMICS TOOLS IN AQUATIC<br />
TOXICOLOGY. A. Miracle 1 , I. Knoebl 1 , D. Bencic 1 ,<br />
D. Lattier 1 , R. Wang 1 , D. Villeneuve 2 and G. Ankley 2 .<br />
1 2 EERD, U.S. EPA, Cincinnati, OH and MED, U.S.<br />
EPA, Duluth, MN. Sponsor: T. Reddy.<br />
#1584 MICROARRAY ANALYSIS OF HEPATIC GENE<br />
EXPRESSION IN COHO SALMON<br />
(ONCORHYNCHUS KISUTCH). H. LaVire 1 , P.<br />
Stapleton 1 , R. Beyer 1 , N. Scholz 2 and G. Evan 1 .<br />
1 2 University <strong>of</strong> Washington, Seattle, WA and NOAA,<br />
Seattle, WA.<br />
#1585 THE USE OF RNA MICROARRAY<br />
TECHNOLOGY AS A BIOMARKER FOR<br />
EXPOSURE OF FATHEAD MINNOW<br />
(PIMEPHALES PROMELAS) TO 2, 4-<br />
DINITROTOLUENE. J. L. Yoo 1 , J. A. Steevens 1 , A.<br />
B. Gibson 1 , C. D. Vulpe 2 and H. M. Wintz 2 .<br />
1 Environmental Laboratory, USACE ERDC, Vicksburg,<br />
MS and 2 Nutritional Sciences and <strong>Toxicology</strong>,<br />
University <strong>of</strong> California, Berkeley, CA.<br />
#1586 GENE EXPRESSION PROFILING IN RAINBOW<br />
TROUT (ONORHYNCUS MYKISS), EXPOSED<br />
TO A VARIETY OF MODEL TOXICANTS. I.<br />
Schultz, S. Hook and A. D. Skillman. Battelle PNNL,<br />
Sequim, WA.<br />
#1587 NONYLPHENOL POLYETHOXYLATE INHIBITS<br />
TRANSPORT OF ESTROGENS INTO BILE IN<br />
THE CHANNEL CATFISH, ICTALARUS<br />
PUNCTATUS. G. C. Hummelke and K. M. Kleinow.<br />
Comparative Biomedical Sciences, Louisiana State<br />
University, Baton Rouge, LA. Sponsor: M. James.<br />
#1588 ESTROGEN EQUIVALENTS AND<br />
CORRESPONDING CHEMICAL ANALYSES OF<br />
MARINE WATER SAMPLES COLLECTED<br />
ALONG A CORAL REEF. A. M. Chaudhary 1 , L. R.<br />
Harrison 2 , S. I. Khan 2 , S. Singh 3 , A. Azua 3 , P.<br />
Gardinali 3 and K. L. Willett 1 . 1 Pharmacology and<br />
Environmental <strong>Toxicology</strong> Research <strong>Program</strong>, The<br />
University <strong>of</strong> Mississippi, University, MS, 2 National<br />
Center for Natural Product Research, The University <strong>of</strong><br />
Mississippi, University, MS and 3 Department <strong>of</strong><br />
Chemistry, Florida International University, Miami, FL.<br />
#1589 MERCURY DISTRIBUTION IN SEDIMENTS AND<br />
UPTAKE BY PLANTS ALONG SNOW AND<br />
CHOCCOLOCCO CREEKS IN NORTHEAST<br />
ALABAMA. A. C. Nichols 1 , D. A. Steffy 1 and S. Al-<br />
Hamdani 2 . 1 Physical and Earth Sciences, Jacksonville<br />
State University, Jacksonville, AL and 2 Biology,<br />
Jacksonville State University, Jacksonville, AL.<br />
#1590 IDENTIFICATION OF SELENOPROTEINS IN<br />
SELENIUM-SENSITIVE TISSUES IN JAPANESE<br />
MEDAKA (ORYZIAS LATIPES) USING<br />
TANDEMLY COUPLED HPLC-ICPMS. K. A.<br />
Thrippleton 1 , A. Mason 3 and D. Schlenk 2 . 1 Department<br />
<strong>of</strong> Environmental <strong>Toxicology</strong>, University <strong>of</strong> California,<br />
Riverside, Riverside, CA, 2 Department <strong>of</strong><br />
Environmental Sciences, University <strong>of</strong> California,<br />
Riverside, Riverside, CA and 3 Department <strong>of</strong> Biological<br />
Sciences, California State University, Long Beach,<br />
Long Beach, CA.<br />
#1591 ACUTE TOXICITY AND BIOACCUMULATION<br />
OF TRIBUTYLTIN IN THE REEF BUILDING<br />
CORAL SPECIES ACROPORA SP. (STAGHORN<br />
CORAL). J. Dwivedi 2 , K. Howell 2 , P. Nguyen 3 and L.<br />
D. Trombetta 1 . 1 Pharmaceutical Sciences, St. Johns<br />
Universtty, Jamaica, NY, 2 Biological Sciences, St.<br />
John’s University, Jamaica, NY and 3 Biological<br />
Sciences, Borough <strong>of</strong> Manhattan Community College,<br />
CUNY, New York.<br />
#1592 HYPERSENSITIVITY OF THE<br />
ELASMOBRANCH UROLOPHUS JAMAICENSIS<br />
(YELLOW STINGRAY) TO TRIBUTYLTIN<br />
EXPOSURE. J. Dwivedi 2 and L. D. Trombetta 1 .<br />
1 Pharmaceutical Sciences, St. Johns Universtty,<br />
Jamaica, NY and 2 Biological Sciences, St. John’s<br />
University, Jamaica, NY.<br />
170<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1593 IN SITU BIOMONITORING TO ASSESS THE<br />
GENOTOXICITY OF PAH-CONTAMINATED<br />
SEDIMENTS TO JUVENILE COHO SALMON<br />
(ONCORHYNCHUS KISUTCH). G. C. Barbee 1 , J.<br />
Barich 5 , B. Duncan 5 , J. W. Bickham 2 , C. W. Matson 2 ,<br />
C. J. Hintze 3 , R. L. Autenrieth 4 , G. Zhou 6 , T. J.<br />
McDonald 6 and K. C. Donnelly 6,1 . 1 Veterinary<br />
Integrative Biomedical Sciences, Texas A&M<br />
University, College Station, TX, 2 Wildlife and Fisheries<br />
Sciences, Texas A&M University, College Station, TX,<br />
3 Statistics, Texas A&M University, College Station, TX,<br />
4 Civil Engineering, Texas A&M University, College<br />
Station, TX, 5 U.S. EPA, Seattle, WA and<br />
6 Environmental and Occupational Health, Texas A&M<br />
University System Health Science Center, College<br />
Station, TX.<br />
#1594 EXPOSURE OF FATHEAD MINNOW TO<br />
FULLERENE AND SINGLE-WALLED CARBON<br />
NANOTUBES. E. Oberdoerster 2,1 , A. Ortiz-Acevedo 3 ,<br />
H. Xie 3 , P. Pantano 3 , R. H. Baughman 3 , I. H.<br />
Musselman 3 , R. K. Draper 3 and G. R. Dieckmann 3 .<br />
1 Biology, Southern Methodist University, Dallas, TX,<br />
2 Duke University Marine Laboratory, Beaufort, NC and<br />
3 Department <strong>of</strong> Chemistry and Nanotech Institute,<br />
University <strong>of</strong> Texas, Dallas, TX.<br />
#1595 TEMPORAL PATTERNS OF MICROCYSTIN-LR<br />
CONTAMINATION IN LAKES OF WEST TEXAS.<br />
M. Billam 1,2 , Q. Cai 1,2 , L. Tang 1,2 , P. Wang 1,2 , S.<br />
Mukhi 1,2 , Z. Wang 1,2 , H. Luo 1,2 , H. Guan 1,2 and J.<br />
Wang 1,2 . 1 Environmental <strong>Toxicology</strong>, Texas Tech<br />
University, Lubbock, TX and 2 The Institute <strong>of</strong><br />
Environmental and Human Health, Texas Tech<br />
University, Lubbock, TX.<br />
#1596 GLUCURONIDATION OF DESMETHYL-<br />
METHOXYCHLOR IN THE CHANNEL CATFISH<br />
INTESTINE AND LIVER. L. D. Stuchal 1 , K. M.<br />
Kleinow 2 and M. James 1 . 1 University <strong>of</strong> Florida,<br />
Gainesville, FL and 2 Louisiana State University, Baton<br />
Rouge, LA.<br />
#1597 DECABROMODIPHENYL OXIDE/ETHER (BDE-<br />
209): INVESTIGATION OF PHOTOLYTIC<br />
DEGRADATION IN A CONSUMER PRODUCT. P.<br />
F. Ranken 2 , M. Hardy 1 and S. D. Landry 2 . 1 Health,<br />
Safety & Environment, Albemarle Corporation, Baton<br />
Rouge, LA and 2 Rearch & Development, Albemarle<br />
Corporation, Baton Rouge, LA.<br />
#1598 HIGH-THROUGHPUT CHEMICAL SCREENING<br />
USING PROTEIN PROFILING OF FISH<br />
PLASMA. R. T. Hudson, M. J. Hemmer, K. A. Salinas,<br />
S. S. Wilkinson, J. Watts, J. T. Winstead, P. S. Harris, A.<br />
Kirkpatrick and C. C. Walker. US-EPA, ORD,<br />
NHEERL, Gulf Breeze, FL. Sponsor: M. Barron.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CADMIUM AND METALLOTHIONEIN<br />
Chairperson(s): Lih-Nan Chou, Boston University School <strong>of</strong> Medicine,<br />
Boston, MA.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1599 LOSS OF GLUTAMATE-CYSTEINE LIGASE<br />
MODIFIER SUBUNIT SENSITIZES CELLS TO<br />
CADMIUM TOXICITY. S. N. Schneider, H. Lei, Y.<br />
Chen, D. W. Nebert and T. P. Dalton. University <strong>of</strong><br />
Cincinnati Medical Center, Cincinnati, OH.<br />
#1600 CADMIUM AND TERT-BUTYL<br />
HYDROPEROXIDE-INDUCED DIFFERENT<br />
PATTERNS OF CHANGES IN ENERGY AND<br />
REDOX STATES IN HEPG2 CELLS–THEIR<br />
CORRELATION WITH THE MODE OF CELL<br />
DEATH. L. C. Yu 1 , K. F. Tse 1 , S. W. Pat 1 , N. K. Mak 1 ,<br />
R. C. Gupta 2 and M. S. Yang 1 . 1 Biology, Hong Kong<br />
Baptist University, HOng Kong, China and 2 <strong>Toxicology</strong>,<br />
Murray State University Breathitt Veterinary Center,<br />
Hopkinsville, KY.<br />
#1601 IDENTIFICATION OF DOSE- AND TIME-<br />
DEPENDENT CHANGES IN CELLULAR<br />
METABOLIC EVENTS IN HEPG2 CELLS UPON<br />
EXPOSURE TO CADMIUM. M. S. Yang 1 , L. C. Yu 1 ,<br />
S. W. Pat 1 , K. M. Li 1 , N. K. Mak 1 and R. C. Gupta 2 .<br />
1 Biology, Hong Kong Baptist University, Hong Kong,<br />
China and 2 <strong>Toxicology</strong>, Murray State University<br />
Breathitt Veterinary Center, Hopkinsville, KY.<br />
#1602 CADMIUM DISRUPTS N-CADHERIN-<br />
DEPENDENT CELL-CELL JUNCTIONS AND<br />
ACTIVATES β-CATENIN MEDIATED NUCLEAR<br />
SIGNALING IN ROS 17/2.8 CELLS. W. C.<br />
Prozialeck 1 , N. Chandar 2 , K. Kolman 2 , P. C. Lamar 1<br />
and M. J. Fay 1 . 1 Pharmacology, Midwestern University,<br />
Downers Grove, IL and 2 Biochemistry, Midwestern<br />
University, Downers Grove, IL.<br />
#1603 UPREGULATION OF γ-GLUTAMYLCYSTEINE<br />
SYNTHETASE EXPRESSION IN CADMIUM-<br />
TREATED RAT FETAL LUNG FIBROBLASTS. X.<br />
Luo 1 , D. Chou 2,1 , L. Chen 2 , Y. Zhao 2 , W. Li 2 and I.<br />
Chou 1 . 1 Microbiology, Boston University School <strong>of</strong><br />
Medicine, Boston, MA and 2 Biochemistry, Boston<br />
University School <strong>of</strong> Medicine, Boston, MA.<br />
#1604 MECHANISMS OF CADMIUM TRANSPORT IN<br />
MDCK CELLS. R. K. Zalups and S. Ahmad. Basic<br />
Sciences, School <strong>of</strong> Medicine, Mercer University,<br />
Macon, GA.<br />
#1605 CADMIUM NEPHROTOXICITY IS ASSOCIATED<br />
WITH A LOSS OF N-CADHERIN MEDIATED<br />
ADHESION AND ALTERATIONS IN<br />
EPITHELIAL POLARITY IN THE PROXIMAL<br />
TUBULE. W. C. Prozialeck and P. C. Lamar.<br />
Pharmacology, Midwestern University, Downers Grove,<br />
IL.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 171
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1606 NECROSIS AND NOT APOPTOSIS IS THE<br />
PREDOMINANT MODE OF CELL DEATH IN<br />
MORTAL HUMAN PROXIMAL TUBULE CELLS<br />
EXPOSED TO CADMIUM CHLORIDE. S. Somji 1 ,<br />
S. H. Garrett 1 , M. Sens 1 and D. A. Sens 2 . 1 Pathology,<br />
University <strong>of</strong> North Dakota, Grand Forks, ND and<br />
2 Surgery, University <strong>of</strong> North Dakota, Grand Forks,<br />
ND.<br />
#1607 CADMIUM-INDUCED CELL CYCLE ARREST IN<br />
RAT KIDNEY EPITHELIAL CELLS IS<br />
MEDIATED THROUGH P53 ACTIVATION. J. Xie<br />
and Z. A. Shaikh. Department <strong>of</strong> Biomedical and<br />
Pharmaceutical Science, University <strong>of</strong> Rhode Island,<br />
Kingston, RI.<br />
#1608 CADMIUM-INDUCED CARCINOGENIC<br />
TRANSFORMATION OF HUMAN PANCREATIC<br />
DUCTAL CELLS. W. Qu 1 , B. Diwan 2 , D. Broderick 1 ,<br />
M. Tsao 3 and M. Waalkes 1 . 1 Laboratory <strong>of</strong> Comparative<br />
Carcinogenesis, NCI at NIEHS, Research Triangle Park,<br />
NC, 2 BRP, SAIC-Frederick, NCI at Frederick,<br />
Frederick, MD and 3 Ontario Cancer Institute, Toronto,<br />
ON, Canada.<br />
#1609 CADMIUM MAY AFFECT THE LIGAND<br />
INDUCED MIGRATORY ABILITY OF<br />
IMMORTALIZED EXTRAVILLOUS<br />
TROPHOBLAST CELLS. M. M. Alvarez and C.<br />
Chakraborty. Pathology, University <strong>of</strong> Western Ontario,<br />
London, ON, Canada. Sponsor: M. Cherian.<br />
#1610 CHRONIC EXPOSURE TO CADMIUM INDUCES<br />
ANEMIA WITH HIGH IRON STORAGE<br />
THROUGH DEFECTIVE IRON UTILIZATION<br />
AND ENHANCED IRON ABSORPTION IN RATS.<br />
H. Horiguchi, E. Oguma, H. Uno and F. Kayama. Jichi<br />
Medical School, Tochigi, Japan. Sponsor: T. Yoshida.<br />
#1611 BEHAVIORAL ALTERATIONS OF C57BL AND<br />
METALLOTHIONEIN KNOCK-OUT MICE<br />
PERINATALLY EXPOSED TO LOW LEVEL OF<br />
CADMIUM. C. Watanabe 1 , A. Watanabe 1 , M. Satoh 2 ,<br />
K. Yoshida 3 , K. Mori 3 , H. Ishitobi 1 and A. Honda 2 .<br />
1 Human Ecology, University <strong>of</strong> Tokyo, Tokyo, Japan,<br />
2 Hygienics, Gifu Pharmaceutical University, Gifu, Japan<br />
and 3 Endocrinology, Tohoku University School <strong>of</strong><br />
Medicine, Sendai, Japan.<br />
#1612 MODULATION OF ACUTE HEPATOTOXICITY<br />
OF CADMIUM BY SIMULTANEOUS<br />
ADMINISTRATION OF COBALT IN MICE. S.<br />
Himeno. Fac. <strong>of</strong> Pharmaceutical Sciences, Tokushima<br />
Bunri University, Tokushima, Japan. Sponsor: M. Sato.<br />
#1613 LIVER INJURY IN METALLOTHIONEIN-NULL<br />
MICE AFTER TREATMENT WITH<br />
THIOACETAMIDE. S. Jiang and G. M. CHERIAN.<br />
Pathology, University.<strong>of</strong> Western Ont, London, ON,<br />
Canada.<br />
#1614 THE NORMAL HUMAN PROSTATE<br />
EPITHELIAL CELL LINE, RWPE-1, AS AN IN<br />
VITRO MODEL SYSTEM OF<br />
METALLOTHIONEIN REGULATION IN THE<br />
PROSTATE. R. K. Singh 1 , S. Somji 1 , M. Sens 1 , D. A.<br />
Sens 2 and S. H. Garrett 1 . 1 Pathology, University <strong>of</strong><br />
North Dakota, Grand Forks, ND and 2 Surgery,<br />
University <strong>of</strong> North Dakota, Grand Forks, ND.<br />
#1615 METALLOTHIONEIN SUSTAINS<br />
METALLOPROTEINASE2 GENE EXPRESSION<br />
IN IMMORTALIZED FIBROBLAST CELLS. M.<br />
Takiguchi 1,2 , M. Higashimoto 2 , S. Suzuki 2 , S.<br />
Yoshihara 1 and M. Sato 2 . 1 Faculty <strong>of</strong> Pharmaceutical<br />
Sciences, Hiroshima International University, Kure,<br />
Hiroshima, Japan and 2 Faculty <strong>of</strong> Pharmaceutical<br />
Sciences, Tokushima Bunri University, Tokushima,<br />
Japan.<br />
#1616 POST-TRANSLATIONAL STABILIZATION OF<br />
METALLOTHIONEIN ISOFORM 3 IN THE<br />
NORMAL BLADDER CELL LINE, UROTSA. D. A.<br />
Sens 1 , S. Somji 2 , R. Singh 2 , M. Sens 2 and S. H. Garrett 2 .<br />
1 Surgery, University <strong>of</strong> North Dakota, Grand Forks, ND<br />
and 2 Pathology, University <strong>of</strong> North Dakota, Grand<br />
Forks, ND.<br />
#1617 ACTIVITY OF METAL-RESPONSIVE<br />
TRANSCRIPTION FACTOR 1 IS MODULATED<br />
BY METALLOTHIONEIN. T. Kimura 1 , N. Itoh 2 , T.<br />
Sone 1 , M. Isobe 1 and K. Tanaka 2 . 1 Department <strong>of</strong><br />
<strong>Toxicology</strong>, Faculty <strong>of</strong> Pharmaceutical Sciences,<br />
Setsunan University, Hirakata, Japan and 2 Department<br />
<strong>of</strong> <strong>Toxicology</strong>, Graduate school <strong>of</strong> Pharmaceutical<br />
Sciences, Osaka University, Suita, Japan.<br />
#1618 THE EFFECT OF METALLOTHIONEIN<br />
ISOFORM-3 MUTANTS ON THE<br />
DIFFERENTIATION OF BREAST CANCER MCF-<br />
7 CELLS. M. Sens 1 , S. H. Garrett 1 , S. Somji 1 and D. A.<br />
Sens 2 . 1 Pathology, University <strong>of</strong> North Dakota, Grand<br />
Forks, ND and 2 Surgery, University <strong>of</strong> North Dakota,<br />
Grand Forks, ND.<br />
#1619 PRODUCTION OF METALLOTHIONEIN<br />
POLYCLONAL ANTIBODIES USING CHICHENS<br />
AS MODEL. E. Brambila 1 , A. Ortiz/Bueno 1 , B. Leon-<br />
Chavez 1 , W. Achanzar 2 and M. P. Waalkes 2 . 1 Clinical<br />
Chemistry, Benemerita Universidad Autonoma de<br />
Puebla, Puebla, Mexico and 2 NIH, Research Triangle<br />
Park, NC.<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: IN VITRO<br />
Chairperson(s): Mohamed Abou-Donia, Duke University, Durham, NC and<br />
Bhupendra Kaphalia, University Of Texas, Galveston, TX.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 9:30 AM–11:00 AM<br />
#1620 INTERACTION OF PB AND DEET, ALONE AND<br />
IN COMBINATION WITH P-GLYCOPROTEIN<br />
EXPRESSED IN E. COLI LEAKY MUTANT. E. M.<br />
El-Masry and M. B. Abou-Donia. Pharmacology and<br />
Cancer Biology, Duke University Medical Center,<br />
Durham, NC.<br />
#1621 HORMESIS EFFECT OF TRACE METALS ON<br />
CULTURED NORMAL AND IMMORTAL HUMAN<br />
MAMMARY CELLS. C. N. Cheng, A. Marino, C. M.<br />
Schmidt, R. Konsoula and F. A. Barile. Pharmaceutical<br />
Sciences, St. John’s University College <strong>of</strong> Pharmacy,<br />
Jamaica, NY.<br />
172<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1629 ETHANOL-INDUCED TOXICITY AND<br />
#1622 INTERACTIVE TOXICITY OF MERCURY AND<br />
9 BioReliance, Rockville, MD.<br />
POLYCHLORINATED BIPHENYL IN THE<br />
NEUROELECTROPHYSIOLOGY OF RAT<br />
EMBRYO. G. Balagopal 1 and H. Chan 2 . 1 Human<br />
<strong>Toxicology</strong> Section–Standards Development Branch,<br />
Ontario Ministry <strong>of</strong> Environment, Toronto, ON, Canada<br />
and 2 Center for Indegenous People’s Nutrition and<br />
APOPTOSIS IN HEPG2 CELLS AND VA-13<br />
CELLS: ROLE OF FATTY ACID ETHYL<br />
ESTERS. H. Wu 1 , K. Bhopale 1 , G. A. Ansari 1 and B. S.<br />
Kaphalia 1 . 1 Pathology, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX, 2 Pathology, University <strong>of</strong> Texas<br />
Medical Branch, Galveston, TX, 3 Pathology, University<br />
Environment, Macdonald Campus, McGill University,<br />
<strong>of</strong> Texas Medical Branch, Galveston, TX and<br />
4<br />
Montreal, QC, Canada.<br />
Pathology, University <strong>of</strong> Texas Medical Branch,<br />
#1623 COMPARATIVE EVALUATION OF<br />
Galveston, TX.<br />
SURFACTANTS ON IN VITRO RABBIT AND<br />
HUMAN CORNEAS. H. F. Edelhauser 1 , B. Boykin 1 ,<br />
#1630 OPTIMIZATION OF AN IN VITRO LONG TERM<br />
CORNEAL CULTURE ASSAY. H. A. Raabe 1 , L.<br />
G. Holley 1 and M. E. Blazka 2 . 1 Emory Eye Center,<br />
Bruner 2 , T. Snyder 1 , N. Wilt 1 and J. W. Harbell 1 .<br />
Emory University, Atlanta, GA and 2 1<br />
Colgate-Palmolive<br />
Institute for In Vitro Sciences, Gaithersburg, MD and<br />
2<br />
Co., Piscataway, NJ.<br />
The Gillette Co., Boston, MA.<br />
#1624 ESTABLISHMENT OF AN IN VITRO BRAIN<br />
BARRIER EPITHELIAL TRANSPORT SYSTEM<br />
FOR TOXICOLOGICAL STUDIES. L. Shi and W.<br />
Zheng. School <strong>of</strong> Health Sciences, Purdue University,<br />
West Lafayette, IN.<br />
#1631 AN EXPANDED REFERENCE DATA-BASE OF IN<br />
VITRO OCULAR IRRITATION SCORES FOR<br />
MARKETED COSMETIC AND PERSONAL CARE<br />
PRODUCTS USING A TISSUE EQUIVALENT<br />
MODEL. R. R. Binetti, M. D. Hines, R. Hamid, S. D.<br />
#1625<br />
Gettings and B. C. Jones. Avon Products Inc., Suffern,<br />
A GERM-LINE STEM CELL LINE AS A MODEL<br />
NY.<br />
FOR EVALUATING THE CYTOTOXICITY OF<br />
NANOPARTICLES IN VITRO. L. Braydich-Stolle 1 , #1632 EFFECT OF THE PROTEASOME INHIBITOR<br />
S. Hussain 2 , J. Schlager 3 and M. H<strong>of</strong>mann 1 .<br />
PS-341 ON NEURONAL CELLS IN VITRO. V.<br />
1 Department <strong>of</strong> Biology, University <strong>of</strong> Dayton, Dayton,<br />
Csizmadia, A. Raczynski, J. Rottman, K. Ganley, P.<br />
OH, 2 ManTech Environmental Technology, Inc.,<br />
Dayton, OH and 3 Air Force Research Laboratory,<br />
Wright-Patterson AFB, Dayton, OH.<br />
Bouchard and V. Sasseville. Drug Safety and<br />
Disposition, Millennium Pharmaceuticals, Inc.,<br />
Cambridge, MA. Sponsor: A. Carl.<br />
#1626 VALIDATION OF AN IN VITRO CELL LINE FOR<br />
SCREENING MYELOTOXICITY. T. Huggett 1 , A.<br />
#1633 DEVELOPMENT OF IN VITRO<br />
CARDIOTOXICITY ASSAY USING RAT<br />
Saad 2 , T. Kelly 1 , F. Pognan 3 , M. Otieno 1 and D. Brott 1 .<br />
CARDIOMYOCYTES CULTURED ON<br />
1 AstraZeneca Pharmaceuticals, Wilmington, DE,<br />
COLLAGEN GEL. T. Inoue, A. Shioda and K.<br />
2 AstraZeneca Pharmaceuticals, Sodertalje, Sweden and<br />
Kobayashi. Pre-Clinical Research Department 2, Chugai<br />
3 AstraZeneca Pharmaceuticals, Alderly Park, United<br />
Pharmaceutical Co., Ltd.,, Kamakura, Japan. Sponsor:<br />
Kingdom.<br />
R. Nagata.<br />
#1627 CORRELATION OF IN VITRO CYTOTOXICITY<br />
WITH PARACELLULAR PERMEABILITY IN<br />
CACO-2 CELLS. R. Konsoula and F. A. Barile.<br />
Pharmaceutical Sciences, St. John’s University College<br />
<strong>of</strong> Pharmacy, Jamaica, NY.<br />
#1634 EVALUATION OF CIGARETTE SMOKE<br />
CYTOTOXICITY UNDER IN VITRO<br />
CONDITIONS. H. E. Hartman, F. Sheabar, G.<br />
Holloway, J. Ye and S. Millett. <strong>Toxicology</strong>, Arista<br />
Laboratories, Inc., Richmond, VA.<br />
#1628 PROTOCOL OPTIMIZATION FOR THE<br />
EVALUATION OF IN VITRO CYTOTOXICITY<br />
ASSAYS FOR ESTIMATING RODENT AND<br />
HUMAN ACUTE SYSTEMIC TOXICITY. M.<br />
Paris 1,2 , J. Strickland 1,2 , W. Stokes 1 , S. Casati 3 , R.<br />
Tice 1,2 , H. Raabe 4 , C. Cao 5 , R. Clothier 6 , J. Haseman 7 ,<br />
P. Crockett 8 , M. Wenk 9 , M. Vallant 7 , G. Mun 4 , G.<br />
Moyer 4 , J. Madren-Whalley 5 , C. Krishna 5 , M. Owen 6<br />
and N. Bourne 6 . 1 NICEATM, NIEHS, Research<br />
Triangle Park, NC, 2 ILS, Inc., Research Triangle Park,<br />
NC, 3 JRC, ECVAM, Ispra, Italy, 4 IIVS, Gaithersburg,<br />
MD, 5 ECBC, USArmy, Aberdeen Proving Ground, MD,<br />
6 University <strong>of</strong> Nottingham, Nottingham, United<br />
Kingdom, 7 NIEHS, Research Triangle Park, NC,<br />
8 Constella Group, Research Triangle Park, NC and<br />
#1635 IN VITRO MODEL FOR VASCULAR<br />
DEVELOPMENT IN MOUSE EMBRYONIC STEM<br />
CELLS. G. RHEE 1 , G. Kim 1 , J. Seok 1 , S. Kim 1 , S.<br />
Kwack 1 , R. Lee 1 , S. Lee 1 , H. Chung 2 and D. Cho 1 .<br />
1 Department <strong>of</strong> <strong>Toxicology</strong>, National Institute <strong>of</strong><br />
Toxicological Research, Seoul, South Korea and 2 Cell<br />
and Gene Therapy Research Institute, Pochon CHA<br />
University, Seoul, South Korea.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 173
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
Wednesday Morning, March 9<br />
9:30 AM to 12:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: SAFETY EVALUATION-SPONTANEOUS<br />
DISEASE AND CONTROL PARAMETERS<br />
Chairperson(s): Carol Auletta, Huntingdon Life Sciences, East Millstone, NJ.<br />
Displayed: 9:30 AM–12:30 PM<br />
Attended: 11:00 AM–12:30 PM<br />
#1636 HISTOPATHOLOGICAL BACKGROUND<br />
FINDINGS IN THE COMMON MARMOSET<br />
(CALLITHRIX JACCHUS). S. Friderichs-Gromoll, J.<br />
Kaspareit and E. Buse. Covance Laboratories GmbH,<br />
48163 Muenster, Germany. Sponsor: G. Weinbauer.<br />
#1637 HISTOPATHOLOGY DATABASE FOR<br />
CARCINOGENICITY STUDIES WITH SPRAGUE-<br />
DAWLEY RATS. A. Babb, V. Price, M. Milligan, K.<br />
Davis, R. D. Jones and J. Seng. <strong>Toxicology</strong>, Charles<br />
River Laboratories–DDS–Arkansas Division, Redfield,<br />
AR.<br />
#1638 A COMPARISON OF PATHOLOGICAL CHANGE<br />
AND SURVIVAL IN DIFFERENT RODENT<br />
STRAINS OVER A TWO-YEAR STUDY<br />
DURATION. J. Noakes, R. W. Lewis and J. A. Wright.<br />
Syngenta Central <strong>Toxicology</strong> Laboratory, Alderley Park,<br />
Macclesfield, United Kingdom. Sponsor: R. Dearman.<br />
#1639 IN-LIFE PARAMETERS AND TUMOUR DATA<br />
FROM CHARLES RIVER CRL:CD-1 ® (ICR) BR<br />
MOUSE DIETARY AND ORAL GAVAGE<br />
TUMORIGENICITY STUDIES TERMINATED<br />
AFTER TWO YEARS. W. Hooks 1 , C. J. Groom 1 and<br />
J. K. Stewart 2 . 1 <strong>Toxicology</strong>, Huntingdon Life Sciences,<br />
Huntingdon, Cambridgeshire, United Kingdom and<br />
2 Pathology, Huntingdon Life Sciences, Huntingdon,<br />
Cambridgeshire, United Kingdom. Sponsor: C. Hardy.<br />
#1640 SPONTANEOUS LESIONS IN CRJ:CD-1(ICR)-<br />
NU/NU MICE BY 106 WEEKS OF AGE DURING<br />
THE OBSERVATION PERIOD. T. Nakamura 1 , T.<br />
Shibanushi 1 , T. Satoshi 1 , K. Kuzutani 1 and M.<br />
Takahashi 2 . 1 Safety Research Department, Kaken<br />
Pharmaceutical Co., Ltd., Sizuoka, Japan and<br />
2 Pathology Peer Review Center, Tokyo, Japan.<br />
#1641 THROMBOCYTOPENIC PURPURA IN<br />
GOTTINGEN MINIPIGS. C. Auletta, H. F. Bolte, S.<br />
J. Gosselin and C. Willard-Mack. Huntingdon Life<br />
Sciences, East Millstone, NJ.<br />
#1642 CLINICAL PATHOLOGY DATABASE FOR NON-<br />
CLINICAL GLP STUDIES WITH LANDRACE -<br />
CROSS SWINE. T. Gartner, P. Powell, V. Price, J.<br />
Seng, R. D. Jones and K. Davis. <strong>Toxicology</strong>, Charles<br />
River Laboratories–DDS–Arkansas Division, Redfield,<br />
AR.<br />
Abstract 1643 is located on page 175.<br />
Wednesday Morning, March 9<br />
11:00 AM to 12:00 NOON<br />
Room 215<br />
INFORMATIONAL SESSION: BIOLUMINESCENT METHODS FOR<br />
ADME/TOX — PRESENTED BY PROMEGA CORP.<br />
Bioluminescence <strong>of</strong>fers significant advantages for configuring sensitive, simple<br />
to perform, high through-put assays with ADME/Tox applications.<br />
Bioluminescent systems will be described that measure the cytotoxicity <strong>of</strong> test<br />
compounds, their capacity to induce apoptosis, their impact on various CYP450<br />
activities and on the multi-drug transporter (MDR1/Pgp).<br />
Wednesday Morning, March 9<br />
11:00 AM to 12:00 NOON<br />
Room 223<br />
INFORMATIONAL SESSION: INTRODUCTION TO REAL-TIME<br />
PCR — PRESENTED BY APPLIED BIOSYSTEMS<br />
An introduction to the fundamentals <strong>of</strong> real-time PCR technology and applications.<br />
This session will include; an overview <strong>of</strong> absolute and relative<br />
quantization methods, chemistry & instrument options, and assay design<br />
considerations.<br />
Wednesday Afternoon<br />
Wednesday Afternoon, March 9<br />
12:00 NOON to 1:00 PM<br />
Room RO1<br />
SPECIAL WORKSHOPS: A CONVERSATION WITH THE<br />
DIRECTORS<br />
The Meet the Directors session is a one-hour special session that will be<br />
formatted like a panel discussion with the leaders <strong>of</strong> several major federal agencies.<br />
The objective <strong>of</strong> this session is to provide meeting attendees a better<br />
understanding <strong>of</strong> the toxicology research activities <strong>of</strong> the FDA, EPA, NIEHS<br />
and NTP. Emphasis will be on change <strong>of</strong> direction or new initiatives that may<br />
impact the practice <strong>of</strong> toxicology in the future. Speakers will also identify<br />
opportunities for non-agency toxicologists to participate in the initiatives <strong>of</strong> the<br />
agency.<br />
• New Direction for Intramural and Extramural Research, Dr. Ken<br />
Olden, NIEHS.<br />
• Changed Emphasis <strong>of</strong> NTP Based on the Recent Vision and Road Map,<br />
Dr. Chris Portier, NTP.<br />
• Current and Future Impact on the FDA Regulatory Actions Based on<br />
NCTR Research, Dr. Dan Casciano, NCTR.<br />
• Current and Future Impact <strong>of</strong> EPA Regulatory Actions Based on EPA<br />
Research, Dr. Bill Farland, U.S. EPA.<br />
174<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Afternoon, March 9<br />
12:00 NOON to 1:00 PM<br />
Room 208<br />
ISSUES SESSION: REORGANIZATION OF THE NIH GRANT<br />
REVIEW PROCESS AND ITS POTENTIAL IMPACT ON<br />
TOXICOLOGY RESEARCH AND TRAINING<br />
Chairperson(s): David Eaton, University <strong>of</strong> Washington, Seattle, WA.<br />
Panelists: Anne Sassaman, Director <strong>of</strong> Extramural <strong>Program</strong>s, NIEHS;<br />
Richard Okita, Administrator, Pharmacological and Physiological Sciences<br />
Branch, NIGMS; Mary Vore, Chair, XNDA Study Section; Alvaro Puga,<br />
Member, XNDA Study Section (Former Chair <strong>of</strong> AL-TOX1); Elliot Postow,<br />
Center for Scientific Review; and Patricia Greenwel, Center for Scientific<br />
Review.<br />
Wednesday Afternoon, March 9<br />
12:15 PM to 1:15 PM<br />
Room 215<br />
INFORMATIONAL SESSION: ADVANCES IN REAL-TIME PCR —<br />
PRESENTED BY APPLIED BIO SYSTEMS<br />
An overview <strong>of</strong> recent advances including; Validated TaqMan® Gene<br />
Expression and SNP Assays for quantization and genotyping <strong>of</strong> the<br />
Cytochromes P450 and other drug metabolizing enzymes, FAST thermal cycling<br />
options, and TaqMan® Assays for microRNA quantization.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO2<br />
With the reorganization <strong>of</strong> the NIH Study Sections, significant changes have<br />
occurred in the way that toxicology-related grants are assigned to study sections<br />
and reviewed. This session will explore the advantages and disadvantages <strong>of</strong> the<br />
reorganization to our discipline, and the implications for toxicology research<br />
and training <strong>of</strong> the next generation <strong>of</strong> environmental health scientists.<br />
Wednesday Afternoon, March 9<br />
12:00 NOON to 1:00 PM<br />
Room RO8<br />
ROUNDTABLE SESSION: CONDUCTING A COMPREHENSIVE<br />
TOXICOLOGICAL AND SAFETY EVALUATION OF<br />
NANOMATERIALS: CURRENT CHALLENGES AND DATA NEEDS<br />
Chairperson(s): William H. Farland, U.S. EPA, Washington, DC.<br />
#1695 12:00 CONDUCTING A COMPREHENSIVE<br />
TOXICOLOGICAL AND SAFETY EVALUATION<br />
OF NANOMATERIALS: CURRENT<br />
CHALLENGES AND DATA NEEDS. M. P.<br />
Holsapple 1 and W. H. Farland 2 . 1 HESI, Washington,<br />
DC and 2 U.S. EPA, Washington, DC.<br />
#1696 12:05 INHALATION AS A CRITICAL EXPOSURE<br />
ROUTE FOR EVALUATING NANOMATERIALS.<br />
T. D. Landry. <strong>Toxicology</strong> and Environmental Research<br />
and Consulting, The Dow Chemical Company, Midland,<br />
MI.<br />
#1697 12:10 DERMAL EXPOSURE ROUTE FOR<br />
EVALUATING NANOMATERIALS. N. A. Monteiro-<br />
Riviere. Center for Chemical <strong>Toxicology</strong> Research and<br />
Pharmacokinetics, North Carolina State University,<br />
Raleigh, NC.<br />
#1698 12:15 THE VALUE OF EXISTING TESTING<br />
STRATEGIES FOR EVALUATING<br />
NANOMATERIALS. J. M. Carter. Central Product<br />
Safety, Procter & Gamble, Cincinnati, OH.<br />
#1699 12:20 MODE OF ACTION CONSIDERATIONS IN THE<br />
EVALUATION OF SAFETY OF ENGINEERED<br />
NANOSCALE MATERIALS. N. J. Walker. NIEHS,<br />
Research Triangle Park, NC.<br />
Abstract 1700 is located on page 179.<br />
SYMPOSIUM SESSION: DEVELOPMENTAL TOXICOLOGY OF THE<br />
LUNG<br />
Chairperson(s): John M. Rogers, U.S. EPA, Research Triangle Park, NC and<br />
Charles G. Plopper, University <strong>of</strong> California, Davis, Davis, CA.<br />
Endorsed by:<br />
Reproductive and Development SS<br />
Student Advisory Committee<br />
Respiratory problems account for a large proportion <strong>of</strong> hospital admissions to<br />
pediatric wards, and the incidence <strong>of</strong> childhood asthma is increasing for<br />
unknown reasons. A number <strong>of</strong> toxicants have been demonstrated to adversely<br />
affect lung development in humans and/or laboratory animals. Lung development<br />
begins early in gestation and continues well after birth. The molecular<br />
control <strong>of</strong> normal lung development has been intensely studied and is becoming<br />
well elucidated, involving multiple complex signaling networks. In contrast,<br />
mechanisms <strong>of</strong> toxicity to the developing lung are poorly understood. This<br />
symposium will present an overview <strong>of</strong> normal lung development and examples<br />
in humans and laboratory animal species <strong>of</strong> chemicals and conditions that<br />
adversely affect lung development. Effects <strong>of</strong> tobacco smoke and constituents<br />
have been well-studied and will be highlighted. Possible modes <strong>of</strong> action for<br />
developmental toxicity to the lung will be presented and research needs will be<br />
discussed.<br />
#1643 1:30 DEVELOPMENTAL TOXICOLOGY OF THE<br />
LUNG. J. M. Rogers. Developmental Biology Branch,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#1644 1:40 GENETIC PATHWAYS CONTROLLING LUNG<br />
MORPHOGENESIS. W. Cardoso. Pulmonary Biology,<br />
Cincinnati Children’s Hospital, Cincinnati, OH.<br />
Sponsor: J. Rogers.<br />
#1645 2:10 EFFECTS OF ENVIRONMENTAL TOBACCO<br />
SMOKE (ETS) ON THE DEVELOPING LUNG. K.<br />
E. Pinkerton, J. L. Peake and J. P. Joad. Center for<br />
Health and the Environment, University <strong>of</strong> California,<br />
Davis, CA.<br />
#1646 2:40 EFFECT OF MATERNAL NICOTINE EXPOSURE<br />
DURING DIFFERENT PHASES OF LUNG<br />
DEVELOPMENT ON LUNG GROWTH IN THE<br />
OFFSPRING: PROTECTICE EFFECT OF<br />
COPPER. G. S. Maritz. Medical Biosciences,<br />
University <strong>of</strong> the Western Cape, Bellville, Western<br />
Province, South Africa. Sponsor: J. Rogers.<br />
#1647 3:10 PRENATAL PERFLUOROOCTANE SULFONATE<br />
EXPOSURE AFFECTS PERINATAL LUNG<br />
DEVELOPMENT AND CAUSES RESPIRATORY<br />
DISTRESS IN RATS. R. C. Grasty. <strong>Toxicology</strong>, UNC<br />
Chapel Hill, Research Triangle Park, NC.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 175
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1648 3:40 EFFECTS OF ENVIRONMENTAL AIR<br />
POLLUTANTS ON POSTNATAL LUNG<br />
DEVELOPMENT. M. Fanucchi. School <strong>of</strong> Veterinary<br />
Medicine, University <strong>of</strong> California, Davis, CA.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO3<br />
SYMPOSIUM SESSION: ROLE OF CELL-CELL AND CELL-MATRIX<br />
INTERACTIONS IN REGULATION OF TOXICANT-MEDIATED CELL<br />
DEATH<br />
Chairperson(s): Ronald Tjalkens, Colorado State University, Fort Collins,<br />
CO.<br />
Endorsed by:<br />
Carcinogenesis SS*<br />
Mechanisms SS<br />
Neurotoxicology SS<br />
Cell-cell interactions are key for the regulation <strong>of</strong> cell survival, cell death and<br />
cell proliferation. Thus, an understanding <strong>of</strong> the interdependency between<br />
different tissue cellular compartments is key to elucidating mechanisms <strong>of</strong> cell<br />
death in response to toxicants. This symposium will provide a timely update on<br />
the molecular mechanisms <strong>of</strong> cell death and its regulation, including the role<br />
played by cell-cell and cell-matrix interactions. This will be illustrated by three<br />
examples <strong>of</strong> the role these pathways play in toxicant response in diverse tissues.<br />
The first speaker will consider how hepatic Kupffer cells are implicated in<br />
normal homeostasis and in hepatocarcinogenesis and can mediate both hepatocyte<br />
survival or cell death, depending on the toxic insult. The second speaker<br />
will address how gap junctional intercellular communication and cell adhesion<br />
are interrelated processes using the example <strong>of</strong> hexachlorobenzene which<br />
induces a down-regulation <strong>of</strong> connexins and E-cadherin in the liver <strong>of</strong> female<br />
but not male rats. The third speaker brings an external perspective and will<br />
discuss how the cell detects and signals damage leading to survival or cell death.<br />
The fourth speaker will address how neuronal trophic and communication functions<br />
are maintained by intricate coupling with associated astroglial cells with<br />
emphasis on neurotoxicants that selectively target astroglial cells, rendering<br />
neurons vulnerable to both physiologic and pathophysiologic stresses. The forth<br />
speaker will also summarise the symposium by uncovering similarities and<br />
common themes in the role <strong>of</strong> the cellular environment in determining cell fate<br />
after toxicant insult. This symposium will be <strong>of</strong> interest both to non-experts<br />
looking to understand this field and those with a specific interest in cell biology,<br />
carcinogenesis, neurotoxicology, apoptosis or cell-cell communication.<br />
#1649 1:30 ROLE OF CELL-CELL AND CELL-MATRIX<br />
INTERACTIONS IN REGULATION OF<br />
TOXICANT-MEDIATED CELL DEATH. R.<br />
Roberts 1 and R. Tjalkens 2 . 1 Safety Assessment,<br />
AstraZeneca, Alderley Park, United Kingdom and<br />
2 Department <strong>of</strong> Environmental and Radiological Health<br />
Sciences, Colorado State University, Fort Collins, CO.<br />
#1650 1:40 CELL-CELL INTERACTIONS AND THEIR ROLE<br />
IN TOXICANT-INDUCED HEPATIC CELL<br />
DEATH. R. Roberts. Safety Assessment, AstraZeneca,<br />
Alderley Park, United Kingdom.<br />
#1651 2:20 MODULATION OF CELL-CELL INTERACTIONS<br />
BY EPIGENETIC HEPATOCARCINOGENS. M.<br />
Charbonneau, I. Plante, N. Raynal and D. G. Cyr.<br />
INRS-Institut Armand-Frappier, Universite du Quebec,<br />
Pointe-Claire, Montreal, QC, Canada.<br />
#1652 3:00 THE REGULATION OF APOPTOSIS: SURVIVAL<br />
SIGNALLING AND THE IMPORTANCE OF<br />
CELL TO CELL COMMUNICATION. C. Dive 1,2 , J.<br />
T. Erler 1 , I. J. Stratford 2 , D. A. Tennant 1,3 and D. R.<br />
Tomlinson 3 . 1 Cellular and Molecular Pharmacology<br />
Group, Cancer Research UK Paterson Institute,<br />
Manchester, United Kingdom, 2 School <strong>of</strong> Pharmacy and<br />
Pharmaceutical sciences, University <strong>of</strong> Manchester,<br />
Manchester, United Kingdom and 3 School <strong>of</strong> Biological<br />
Sciences, University <strong>of</strong> Manchester, Manchester, United<br />
Kingdom. Sponsor: R. Roberts.<br />
#1653 3:40 NEURO-GLIAL INTERACTIONS IN BASAL<br />
GANGLIA DYSFUNCTION: INSIGHTS FROM<br />
MANGANESE NEUROTOXICITY. R. Tjalkens.<br />
<strong>Toxicology</strong> Section, Department <strong>of</strong> Environmental and<br />
Radiological Health Sciences, Colorado State<br />
University, Fort Collins, CO.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO4<br />
SYMPOSIUM SESSION: THE UBIQUITIN- PROTEASOME SYSTEM<br />
AS A BIOLOGICAL TARGET IN TOXIC RESPONSES AND DISEASE<br />
Chairperson(s): Richard Pollenz, University <strong>of</strong> South Florida, Tampa, FL and<br />
Elaine M. Faustman, Institute for Risk Analysis & Risk Communication,<br />
Seattle, WA.<br />
Endorsed by:<br />
Mechanisms SS<br />
Neurotoxicology SS<br />
The ubiquitin-proteasome system is an essential pathway involved in covalently<br />
modifying proteins to influence their function and turnover. The cascade is initiated<br />
by an activating enzyme (E1), that binds to the 76 amino acid ubiquitin<br />
protein (UB). The E1 then transfers the UB to an E2 carrier protein. Following<br />
this transfer, a UB ligase enzyme (E3) covalently links the UB to a target<br />
protein. It is the E3, or E3/E2 complex that supplies the target specificity <strong>of</strong> the<br />
ubiquitination event. Genome mining has identified 530 possible genes<br />
encoding E1, E2, E3, UB and deubiquitinating enzymes (DUB). Ubiquinated<br />
substrates are usually recognized by the 20S or 26S proteasome complexes and<br />
destroyed, although recent studies suggest that UB or UB-like modification does<br />
not always result in destruction. The proteasomes are huge multiprotein<br />
complexes that can be found in both the cytoplasm and nucleus. Overall, the<br />
proteasome accounts for 1% <strong>of</strong> a cells protein. Due to the number <strong>of</strong> gene products<br />
required for the ubiquitin-proteasome system, it is a prime target in various<br />
human diseases states and cancer. Defects in the system have been implicated in<br />
neurodegenerative diseases such as Parkinsons and Alzheimers. In addition,<br />
studies continue to suggest that that the various enzymes <strong>of</strong> the pathway may be<br />
targets for toxicologically relevant compounds typified by arsenic, cadmium,<br />
TCDD and ethanol. In addition, the ubiquitin-proteasome system is implicated<br />
in the ligand mediated degradation <strong>of</strong> important transcription factors such as<br />
p53, steroid hormone receptors and the aryl hydrocarbon receptor (AHR). Due<br />
to these findings, the enzymes <strong>of</strong> the ubiquitin-proteasome pathway have<br />
become important targets in toxicology screens and in drug discovery paradigms.<br />
#1654 1:30 THE UBIQUITIN- PROTEASOME SYSTEM AS A<br />
BIOLOGICAL TARGET IN TOXIC RESPONSES<br />
AND DISEASE. R. S. Pollenz. Biology, University <strong>of</strong><br />
South Florida, Tampa, FL.<br />
176<br />
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and ToxExpo<br />
<strong>Program</strong> Description<br />
#1655 1:37 TOXICANT AFFECTS ON UBIQUITIN-<br />
PROTEOSOME SYSTEMS: LESSONS FROM<br />
CROSS-COMPOUND AND CROSS-SYSTEM<br />
ASSESSMENTS. E. Faustman, X. Yu, J. Sidhu and J.<br />
Robinson. Department <strong>of</strong> Environmental and<br />
Occupational Health Sciences, University <strong>of</strong><br />
Washingotn, Seattle, WA.<br />
#1656 2:17 ENVIRONMENTAL FACTORS, UBIQUITIN-<br />
PROTEOSOME DYSFUNCTION AND<br />
PARKINSON’S DISEASE. A. G. Kanthasamy.<br />
Biomedical Sciences, Iowa State University, Ames, IA.<br />
#1657 2:57 EFFECT OF ETHANOL ADMINISTRATION ON<br />
PROTEASOME ACTIVITY IN LIVER AND IN<br />
CULTURED HEPATOMA CELLS. T. M. Donohue,<br />
N. A. Osna and D. L. Clemens. Research, VA Medical<br />
Center, Omaha, NE. Sponsor: R. Pollenz.<br />
#1658 3:37 THE UBIQUITIN-PROTEASOME SYSTEM IN<br />
REGULATION OF NUCLEAR TRANSCRIPTION<br />
FACTORS AND SIGNAL TRANSDUCTION<br />
PATHWAYS. R. S. Pollenz, J. Popat, M. de la Pena and<br />
J. McQuown. Biology, University <strong>of</strong> South Florida,<br />
Tampa, FL.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
La Louisiane Ballroom B<br />
#1659 1:30 WHY METALS BECOME NEUROTOXIC. W.<br />
Zheng. School <strong>of</strong> Health Sciences, Purdue University,<br />
West Lafayette, IN.<br />
#1660 1:50 SELECTIVE BLOOD-BRAIN BARRIER<br />
TRANSPORT OF ALUMINUM, MANGANESE,<br />
AND OTHER METALS IN METAL-INDUCED<br />
NEURODEGENERATION. R. A. Yokel. College <strong>of</strong><br />
Pharmacy, University <strong>of</strong> Kentucky Medical Center,<br />
Lexington, KY.<br />
#1661 2:30 INTERACTION OF COPPER AND ZINC WITH β-<br />
AMYLOID IN PATHOGENESIS OF<br />
ALZHEIMER’S DISEASE. A. I. Bush. Genetics and<br />
Aging Research Unit, Harvard Medical School and<br />
Massachusetts General Hospital, Charlestown, MA.<br />
Sponsor: W. Zheng.<br />
#1662 3:10 BINDING TO SUBCELLULAR STRUCTURES IN<br />
METHYLMERCURY-INDUCED<br />
NEURODEGENERATIVE DAMAGE. K. R. Reuhl.<br />
Pharmacology & <strong>Toxicology</strong>, Rutgers University,<br />
Piscataway, NJ.<br />
#1663 3:50 METAL-METAL INTERACTIONS IN<br />
MANGANESE-INDUCED PARKINSONISM. W.<br />
Zheng. School <strong>of</strong> Health Sciences, Purdue University,<br />
West Lafayette, IN.<br />
Abstract 1664 is located on page 199.<br />
SYMPOSIUM SESSION: WHAT MAKES METALS NEUROTOXIC IN<br />
NEURODEGENERATIVE DISORDERS?<br />
Chairperson(s): Wei Zheng, Purdue University, West Lafayette, IN and Robert<br />
A. Yokel, University <strong>of</strong> Kentucky, Lexington, KY.<br />
Endorsed by:<br />
Metals SS*<br />
Neurotoxicology SS<br />
Risk Assessment SS<br />
Neurodegenerative diseases are characterized by progressive atrophy and<br />
dysfunction <strong>of</strong> anatomically or physiologically related neurological<br />
systems.Cumulative evidence suggests a role <strong>of</strong> metals in the etiology <strong>of</strong><br />
numerous such diseases.For example, excess manganese (Mn) and iron (Fe) in<br />
particular brain regions have been associated with Parkinsonism; copper (Cu)<br />
and zinc (Zn) have been implicated in extracellular deposits <strong>of</strong> amyloid plaques<br />
in Alzheimer’s brains; overload <strong>of</strong> aluminum (Al) in the brain has also been<br />
controversially related to Alzheimer’s disease.Moreover, exposure to organic<br />
metals such as methylmercury (MeHg) has been linked to persistent<br />
psychomotor disturbances. However, the imminent question remains as to what<br />
factors may render metals, either essential or xenobiotic, more prone to being<br />
harmful in sporadic or hereditary neurodegenerative diseases. Understandably,<br />
interactions <strong>of</strong> these metals with genetic components, proteins, metal transport<br />
machineries, and cellular redox mechanisms, may signify some <strong>of</strong> the key<br />
factors in metal-induced neurotoxicities. This symposium will address the<br />
current understanding <strong>of</strong> biochemical characteristics <strong>of</strong> metals that are implicated<br />
in neurodegenerative disorders, including (1) metal-protein interaction<br />
such as Cu and Zn in beta-amyloid aggregation, (2) metal-metal interaction such<br />
as Mn in alteration <strong>of</strong> brain Fe functions, (3) metal-subcellular structure interaction<br />
such as MeHg and microtubules, (4) metal-transporter interaction such as<br />
Al speciation in brain Al metabolomics, and (5) metal-redox pathway interaction<br />
implicated in metal-induced oxidative stress. The symposium will be <strong>of</strong><br />
interest to those who are engaged in metal toxicology, neuroscience, neurotoxicology,<br />
risk assessment, regulatory management, occupational health, and<br />
toxicology education.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 177
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room 207<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room 220<br />
WEDNESDAY<br />
WORKSHOP SESSION: CONFLICT OF INTEREST<br />
Chairperson(s): Jacques Maurissen, The Dow Chemical Company, Midland,<br />
MI and Steven Gilbert, Institute <strong>of</strong> Neurotoxicology and Neurological<br />
Disorders, Seattle, WA.<br />
Endorsed by:<br />
Board <strong>of</strong> Publications<br />
Ethical Legal and Social Issues SS*<br />
Regulatory Affairs and Legislative Assistance Committee<br />
Regulatory and Safety Evaluation SS<br />
The conflict <strong>of</strong> interest issue has recently been the subject <strong>of</strong> much attention<br />
from the points <strong>of</strong> view <strong>of</strong> editorial policy and electoral policy to scientific advisory<br />
boards. The perception is that some scientists performing or evaluating<br />
research may be tempted to overlook an adverse effect in a research project<br />
(hoping to please the sponsor and to secure future funding from the same<br />
source); likewise, other scientists may be tempted to overemphasize the significance<br />
<strong>of</strong> a positive result in their research (to gain access to additional grant<br />
support from private or institutional foundations or to favor donations from the<br />
general public). A number <strong>of</strong> scientific journals (including Toxicological<br />
Sciences) have recently addressed or reviewed the issue <strong>of</strong> conflict <strong>of</strong> interest.<br />
Similarly, a number <strong>of</strong> institutions have also codified their policy to help in the<br />
selection <strong>of</strong> members for scientific advisory boards. A number <strong>of</strong> questions can<br />
be asked around several themes: What is a financial conflict <strong>of</strong> interest? What<br />
about grant renewal, university tenure? What is the importance <strong>of</strong> non-financial<br />
conflicts <strong>of</strong> interest in the decision process, e.g., number <strong>of</strong> publications,<br />
academic competition, public/pr<strong>of</strong>essional visibility, satisfaction <strong>of</strong> accomplishment,<br />
loyalty? When does a conflict start and stop being a conflict, apparent or<br />
real? Should a scientist with a real conflict <strong>of</strong> interest be prevented from<br />
publishing an editorial or a review paper on the basis <strong>of</strong> a conflict <strong>of</strong> interest?<br />
What if the conflict is not real but perceived? Should a perceived conflict <strong>of</strong><br />
interest be enough to disqualify an otherwise competent scientist from election<br />
to a panel? What is the role <strong>of</strong> full disclosure in a successful conflict <strong>of</strong> interest<br />
policy? A group <strong>of</strong> five panelists (from diverse backgrounds) will present their<br />
views concerning the conflict <strong>of</strong> interest.<br />
#1678 1:30 CONFLICT OF INTEREST. J. P. Maurissen 2 and S.<br />
G. Gilbert 1 . 1 INND, Seattle, WA and 2 Neurotoxicology,<br />
Dow Chemical Company, Midland, MI.<br />
#1679 1:45 WHAT IS A “CONFLICT OF INTEREST”? T. L.<br />
Beauchamp. Kennedy Institute <strong>of</strong> Ethics, Georgetown<br />
University, Washington, DC. Sponsor: S. Gilbert.<br />
#1680 2:15 CONFLICT OF INTEREST IN THE<br />
PUBLICATION PROCESS. L. D. Lehman-<br />
McKeeman. Bristol Myers Squibb Co., Princeton, NJ.<br />
#1681 2:45 ROLE OF GOVERNMENT OVERSIGHT. B. A.<br />
Schwetz. Office for Human Research Protections,<br />
Rockville, MD.<br />
#1682 3:15 MANAGING CONFLICTS OF INTEREST: DOES<br />
DISCLOSURE GO FAR ENOUGH? M. Goozner.<br />
Cntr for Sciences. in the Public Intrst, Washington, DC.<br />
Sponsor: S. Gilbert.<br />
#1683 3:45 CONFLICT OF INTEREST AND BIAS: A<br />
VIEWPOINT FROM INDUSTRY. C. Barrow. Dow<br />
Chemical Company, Washington, DC.<br />
WORKSHOP SESSION: DOSIMETRY AND POTENTIAL IMPACTS<br />
ON REPRODUCTIVE/DEVELOPMENTAL STUDY DESIGN AND<br />
INTERPRETATION FOR RISK OR SAFETY ASSESSMENT<br />
Chairperson(s): Hugh Barton, U.S. EPA, Research Triangle Park, NC and Ed<br />
Carney, Dow Chemical Company, Midland, MI.<br />
Endorsed by:<br />
Biological Modeling SS<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Reproductive and developmental toxicity studies in animals are utilized in<br />
assessing the potential adverse effects <strong>of</strong> chemicals and drugs in pregnant<br />
women, nursing infants, and children. The results <strong>of</strong> these studies are extrapolated<br />
to humans primarily based on the dose or the exposure in the mother due<br />
to the complexity <strong>of</strong> describing the dose, pharmacokinetics, and tissue<br />
dosimetry <strong>of</strong> chemicals during pregnancy, lactation, and postweaning periods.<br />
Transporters are increasingly recognized as a key factor in dosimetry during<br />
early life along with development <strong>of</strong> metabolism and other clearance processes.<br />
For pharmaceuticals, measurement <strong>of</strong> maternal blood levels, and sometimes<br />
placental and lactational transfer, are addressed for safety assessment. Classical<br />
and physiologically-based pharmacokinetic analyses are increasingly being<br />
applied across these life stages <strong>of</strong> reproduction. Identification <strong>of</strong> the critical<br />
window <strong>of</strong> sensitivity, and how this critical period and its associated pharmacokinetics<br />
correlates with humans, is a significant challenge. This workshop will<br />
present approaches to characterizing measures <strong>of</strong> internal dose in reproductive<br />
and developmental toxicity studies, and how this impacts study designs and<br />
applications for safety and risk assessment.<br />
#1684 1:30 DOSIMETRY AND<br />
REPRODUCTIVE/DEVELOPMENTAL STUDY<br />
DESIGN AND INTERPRETATION FOR RISK OR<br />
SAFETY ASSESSMENT. E. Carney 2 and H. A.<br />
Barton 1 . 1 U.S. EPA, Research Triangle Park, NC and<br />
2 <strong>Toxicology</strong> & Environmental Research & Consulting,<br />
Dow Chemical Company, Midland, MI.<br />
#1685 1:40 LIFE-STAGE DEPENDENT DOSIMETRY AND<br />
POTENTIAL IMPACTS ON RISK ASSESSMENT.<br />
H. A. Barton. U.S. EPA, Research Triangle Park, NC.<br />
#1686 2:10 INCORPORATING DOSIMETRY IN<br />
DEVELOPMENTAL TOXICITY ASSESSMENTS:<br />
STUDY DESIGN AND DATA INTERPRETATION.<br />
E. Mylchreest and S. A. Gannon. DuPont Haskell<br />
Laboratory, Newark, DE.<br />
#1687 2:40 TRANSPORTERS DURING DEVELOPMENT. C.<br />
D. Klaassen. Pharmacology, U Kansas Med. Ctr,<br />
Kansas City, KS.<br />
#1688 3:10 PHARMACEUTICAL PERSPECTIVE ON<br />
DOSIMETRY IN REPRODUCTIVE AND<br />
DEVELOPMENTAL STUDIES AND THE IMPACT<br />
ON DRUG DEVELOPMENT. G. Pastino. Drug<br />
Metabolism and Pharmacokinetics, Schering Plough<br />
Research Institute, Lafayette, NJ.<br />
#1689 3:40 PBPK MODELING OF EARLY LIFESTAGES AND<br />
ESTIMATION OF DOSIMETRY FOR RISK<br />
ASSESSMENT. H. Clewell 1 and R. Clewell 2 .<br />
1 2 ENVIRON, Ruston, LA and CIIT Centers for Health<br />
Research, Research TrianglePark, NC.<br />
178<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO6<br />
WORKSHOP SESSION: SKIN MODEL SELECTION FOR SAFETY<br />
ASSESSMENT OF TOPICAL DRUG PRODUCTS: REGULATORY<br />
AND INDUSTRY PERSPECTIVES<br />
Chairperson(s): Guilin Gary Qiao, U.S. FDA, Rockville, MD and Abby<br />
Jacobs, U.S. FDA, Rockville, MD.<br />
Endorsed by:<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Improper skin model selection in drug R&D and regulatory approval may<br />
under- or over-estimate systemic toxicity risk <strong>of</strong> a topical drug, resulting in<br />
significant resource and public health costs. Comparison and careful selection<br />
<strong>of</strong> in vitro versus in vivo, animal versus human, healthy versus diseased skin<br />
models under various exposure conditions during topical drug development and<br />
approval are critical. However, our knowledge base in chemical dermal absorption<br />
is mainly built on the healthy skin absorption data. For this reason, the<br />
regulatory evaluation <strong>of</strong> drug safety pr<strong>of</strong>ile has been largely based on healthy<br />
skin study data submitted by drug sponsors, especially in the animal drug sector.<br />
FDA, per its general guidelines, requires target animal safety pr<strong>of</strong>iles to be<br />
tested in healthy subjects for veterinary drug products including topical drugs to<br />
be applied to diseased skin. Human dermal drug safety testing employs a wider<br />
range <strong>of</strong> animal models for various purposes. The question is weather the<br />
healthy skin data can predict what happens in patients with compromised skin<br />
and weather our testing methods are reflecting the most recent progresses in this<br />
filed. Data have suggested diseased or damaged skin can compromise skin<br />
barrier function, and thus enhance systemic as well as local toxicity risk. Those<br />
issues deserve closer research and regulatory attention. Through this workshop,<br />
impact <strong>of</strong> compromised skin barrier function by skin diseases or by other exposure<br />
variables on systemic versus local, short term versus long term risk are<br />
addressed from academic research, industrial R&D, and regulatory approval<br />
perspectives. Comparative skin histology, skin biology, skin barrier function<br />
assessment, dermal absorption, cutaneous drug disposition, and government<br />
guidelines for safety testing <strong>of</strong> human and animal dermal drugs are to be<br />
discussed with research data. Inputs from the scientific community on those<br />
issues are helpful for future government guideline revisions.<br />
#1690 1:30 SKIN MODEL SELECTION FOR SAFETY<br />
ASSESSMENT OF TOPICAL DRUG PRODUCTS:<br />
REGULATORY AND INDUSTRY<br />
PERSPECTIVES. G. G. Qiao. CVM and CDER, U.S.<br />
FDA, Rockville, MD.<br />
#1691 1:40 COMPARATIVE MODEL SELECTION<br />
BETWEEN SPECIES AND ABNORMAL SKIN:<br />
MORPHOLOGY, DERMAL DRUG DELIVERY,<br />
AND OVERALL BARRIER FUNCTION. N. A.<br />
Monteiro-Riviere. Center for Chemical <strong>Toxicology</strong><br />
Research and Pharmacokinetics, North Carolina State<br />
University, Raleigh, NC.<br />
#1692 2:20 SKIN MODEL SELECTION IN TOPICAL DRUG<br />
R&D AND REGULATORY APPROVAL:<br />
CHALLENGES AND SOLUTIONS IN DRUG<br />
SAFETY ASSESSMENT. G. G. Qiao 1 and A. C.<br />
Jacobs 2 . 1 CVM, U.S. FDA, Rockville, MD and 2 CDER,<br />
U.S. FDA, Rockville, MD.<br />
#1693 3:00 TEST METHODS AND MODELS USED IN THE<br />
DEVELOPMENT OF TOPICALLY-APPLIED<br />
PRODUCTS. J. F. Nash. Central Product Safety,<br />
Procter & Gamble Company, Cincinnati, OH.<br />
#1694 3:40 GUIDANCE AND ANIMAL MODEL SELECTION<br />
FOR SAFETY ASSESSMENTS FOR DERMAL<br />
DRUG PRODUCT DEVELOPMENT AND<br />
APPROVAL. A. Jacobs 1 and G. Qiao 2 . 1 CDER U.S.<br />
FDA, Rockville, MD and 2 CVM U.S. FDA, Rockville,<br />
MD.<br />
Abstracts 1695-1699 moved forward to follow 1642.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO1<br />
PLATFORM SESSION: BIOINFORMATICS: APPLICATIONS TO<br />
TOXICOLOGY<br />
Chairperson(s): Kyle Kolaja, Iconix, Mountain View, CA and John Schlager,<br />
Wright Patterson, AFB, Wright-Patterson AFB, OH.<br />
#1700 1:30 SUPPORT VECTOR MACHINE ALGORITHM<br />
FOR THE PREDICTION OF GENE FUNCTION<br />
USING A LARGE CHEMOGENOMIC<br />
REFERENCE DATABASE. G. Natsoulis, M. Fielden,<br />
W. Hu, S. Dunlea, B. Eynon and K. Kolaja.<br />
Chemogenomics and <strong>Toxicology</strong>, Iconix<br />
Pharmaceuticals Inc., Mountain View, CA.<br />
#1701 1:50 A MULTIVARIATE DATA ANALYSIS<br />
TECHNIQUE FROM THE SYNTHESIS OF A<br />
PRIORI KNOWLEDGE AND EMBEDDED<br />
STATISTICAL STRUCTURE. P. Wilson. Air Force<br />
Research Laboratory, Wright-Patterson AFB, OH.<br />
Sponsor: J. Schlager.<br />
#1702 2:10 PROBING ALTERATIONS OF THE<br />
MITOCHONDRIAL MEMBRANE PROTEOME IN<br />
A MURINE MODEL OF PARKINSON’S DISEASE<br />
USING LIQUID CHROMATOGRAPHY-TANDEM<br />
MASS SPECTROMETRY. D. R. Cawthon 1 , J. A.<br />
Gantt 2 , M. B. Goshe 2 , Z. A. Xu 1 , W. Slikker 1 and S. F.<br />
Ali 1 . 1 Neurotoxicology, U.S. FDA/NCTR, Jefferson, AR<br />
and 2 Molecular and Structural Biochemistry, NC State<br />
University, Raleigh, NC.<br />
#1703 2:30 NOVEL NETWORK ANALYSIS FOR<br />
TOXICOLOGY USING KEYMOLNET. H. Sato, M.<br />
Fukuda, M. Shigetaka, N. Iwasaki, Y. Inoue, Y.<br />
Kikushima, K. Nakanishi, M. Ogura, Y. Wakamatsu, H.<br />
Kuriki, Y. Mizoguchi, R. Taniguchi, T. Nanba, Y. Ozeki,<br />
A. Nogi and A. Itai. Bioinformatics, Institute <strong>of</strong><br />
Medicinal Molecular Design, Inc. (IMMD), Tokyo,<br />
Japan. Sponsor: Y. Aoki.<br />
#1704 2:50 BIOINFORMATICS METHODS FOR LIVER<br />
CANCER ANALYSIS USING CROSS SPECIES<br />
MAPPING BASED ON RAT GENE EXPRESSION<br />
PROFILING. W. Tong 1 , H. Fang 2 , R. Perkins 2 , L. Shi 1 ,<br />
S. H. Yim 3 , J. M. Ward 3 and Y. P. Dragan 1 . 1 Systems<br />
<strong>Toxicology</strong>, National Center for Toxicolological<br />
Research, Jefferson, AR, 2 Division <strong>of</strong> Bioinformatics,<br />
Z-Tech, NCTR, Jefferson, AR and 3 Center for Cancer<br />
Research, National Cancer Institiute, Bethesda, MD.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 179
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1705 3:10 ASSESSMENT OF SPECTRAL INTEGRATION<br />
AND NORMALIZATION IN NMR-BASED<br />
METABONOMIC ANALYSES. B. Webb-Robertson 1 ,<br />
D. F. Lowry 1 , K. H. Jarman 1 , S. J. Harbo 2 , Q. R.<br />
Meng 2 , J. G. Pounds 1 and K. M. Lee 2 . 1 Pacific<br />
Northwest National Laboratory, Richland, WA and<br />
2 <strong>Toxicology</strong> Northwest, Battelle Memorial Institute,<br />
Richland, WA.<br />
#1706 3:30 THE COMPARATIVE TOXICOGENOMICS<br />
DATABASE (CTD). C. Mattingly 1 , M. Rosenstein 1 , G.<br />
Colby 1 , J. N. Forrest 2,1 and J. L. Boyer 2,1 . 1 MDI<br />
Biological Laboratory, Salisbury Cove, ME and 2 Yale<br />
University School <strong>of</strong> Medicine, New Haven, CT.<br />
Sponsor: W. Toscano.<br />
#1707 3:50 WITHIN- AND BETWEEN-ANIMAL VARIATION,<br />
AND REFERENCE RANGES OF<br />
HEMATOLOGICAL AND SERUM<br />
BIOCHEMICAL PARAMETERS IN<br />
CYNOMOLGUS MONKEYS. T. Koga 1,2 , K.<br />
Kanefuji 2 and R. Nagata 3 . 1 SNBL, Kagoshima, Japan,<br />
2 The Institute <strong>of</strong> Statistical Mathematics, Tokyo, Japan<br />
and 3 SNBL, Tokyo, Japan.<br />
#1708 4:10 THEORETICAL TARGET SEQUENCE FOR THE<br />
INTERACTION BETWEEN AFLATOXIN B1 AND<br />
PROTEINS. J. Olivero-Verbel, I. Lans, I. Ospino, R.<br />
Vivas, E. Martínez and A. Padilla. Environmental and<br />
Computational Chemistry Group, University <strong>of</strong><br />
Cartagena, Cartagena, Bolivar, Colombia.<br />
#1709 4:30 A DATABASE FOR TRACKING<br />
TOXICOGENOMIC SAMPLES AND<br />
PROCEDURES WITH GENOMIC, PROTEOMIC<br />
AND METABONOMIC COMPONENTS. W. Bao 1 ,<br />
J. Fostel 2 , M. D. Waters 2 , B. Merrick 2 , D. Ekman 1 , M.<br />
Kostich 1 , J. Schmid 1 and D. J. Dix 1 . 1 Office <strong>of</strong><br />
Research and Development, U.S. EPA, Research<br />
Triangle Park, NC and 2 National Center for<br />
Toxicogenomics, National Institute <strong>of</strong> Environmental<br />
Health Sciences, Research Triangle Park, NC.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room 208<br />
PLATFORM SESSION: HYPERSENSITIVITY I<br />
Chairperson(s): Jean Regal, University <strong>of</strong> Minnesota, Pharmacology, Duluth,<br />
MN and Marsha Ward, U.S. EPA, Environmental <strong>Toxicology</strong>, Research Triangle<br />
Park, NC.<br />
#1710 1:30 INFLUENCE OF PROTEIN ALLERGENS ON<br />
DENDRITIC CELL ACTIVATION. S. M. George 1 ,<br />
M. Cumberbatch 2 , C. Portsmouth 2 , A. Destrument 2 , R.<br />
J. Dearman 2 , D. Archer 1 , M. Alcocer 1 and I. Kimber 2 .<br />
1 School <strong>of</strong> Biological Sciences, Nottingham University,<br />
Nottingham, United Kingdom and 2 Immunology,<br />
Syngenta CTL, Macclesfield, United Kingdom.<br />
#1711 1:52 CUTANEOUS CYTOKINE SECRETION<br />
PROFILES INDUCED IN MICE FOLLOWING<br />
EXPOSURE TO IRRITANTS OR CHEMICAL<br />
ALLERGENS. M. Cumberbatch, R. J. Dearman and I.<br />
Kimber. Immunology, Syngenta CTL, Macclesfield,<br />
United Kingdom.<br />
#1712 2:14 VALIDATION OF A MURINE MODEL OF<br />
CHEMICAL-INDUCED ASTHMA IN MICE,<br />
USING TRIMELLITIC ANHYDRIDE AND 1-<br />
CHLORO-2, 4-DINITROBENZENE. J. Vanoirbeek 1 ,<br />
M. Tarkowski 2 , N. Ben 1 and P. Hoet 1 . 1 Lab. <strong>of</strong><br />
Pneumology–Lungtoxicology, K.U.Leuven, Leuven,<br />
Belgium and 2 Department <strong>of</strong> Immunotoxicology,<br />
Institute <strong>of</strong> Occupational Medicine, Lodz, Poland.<br />
#1713 2:36 CCL2 KO MICE DEMONSTRATE ENHANCED<br />
TH2 RESPONSES FOLLOWING DERMAL<br />
SENSITIZATION. L. P. Myers 1 , P. Simeonova 2 and B.<br />
J. Meade 1 . 1 Agriculture and Immunotoxicology Group,<br />
NIOSH, Morgantown, WV and 2 Health Effects<br />
Laboratory Division, NIOSH, Morgantown, WV.<br />
#1714 2:58 DOSE-DEPENDENT INCREASE IN THE<br />
PRODUCTION OF NERVE GROWTH FACTOR,<br />
NEUROTROPHIN-3, AND NEUROTROPHIN-4 IN<br />
A PENICILLIUM CHRYSOGENUM-INDUCED<br />
ALLERGIC ASTHMA MODEL. Y. Chung 1 , A.<br />
Farraj 2 , N. H. Coates 3 , S. H. Gavett 3 and M. D. Ward 3 .<br />
1 Environmental Sciences and Engineering, UNC/U.S.<br />
EPA, Chapel Hill, NC, 2 CVM, NCSU, Raleigh, NC and<br />
3 ORD, NHEERL, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#1715 3:20 CYTOKINE, ANTIBODY AND PULMONARY<br />
RESPONSES IN BALB/C MICE FOLLOWING<br />
DERMAL EXPOSURE TO SELECTED<br />
DIISOCYANATES. E. H. Boykin 1 , N. H. Coates 1 , L.<br />
M. Plitnik 2 , D. L. Doerfler 1 , S. H. Gavett 1 and M. K.<br />
Selgrade 1 . 1 ETD, U.S. EPA, Research Triangle Park,<br />
NC and 2 Merck and Co., Inc., West Point, PA.<br />
#1716 3:42 IN UTERO EXPOSURE TO GENISTEIN (GEN) BY<br />
GAVAGE INCREASES IGE AND IGG1<br />
PRODUCTION BY ADULT B6C3F1 MICE<br />
FOLLOWING TREATMENT WITH<br />
RESPIRATORY ALLERGEN TRIMELLITIC<br />
ANHYDRIDE (TMA). T. L. Guo, R. P. Chi, W.<br />
Auttachoat, D. M. Hernandez and K. L. White, Jr..<br />
Virginia Commonwealth University, Richmond, VA.<br />
#1717 4:04 DIFFERENTIAL EXPRESSION OF ARGINASE IN<br />
OVALBUMIN (OA) AND TRIMELLITIC<br />
ANHYDRIDE (TMA) INDUCED ASTHMA. J. F.<br />
Regal 1 , A. L. Greene 1 , R. R. Regal 2 , M. Rutherford 4 , C.<br />
Giulivi 3 , G. Flickinger 4 , J. Hendrickson 4 and M.<br />
Mohrman 1 . 1 Biochemistry & Molecular Biology,<br />
University <strong>of</strong> Minnesota, Duluth, MN, 2 Mathematics &<br />
Statistics, University <strong>of</strong> Minnesota, Duluth, MN,<br />
3 Molecular Biosciences, University <strong>of</strong> California-Davis,<br />
Davis, CA and 4 Veterinary & Biomedical Sciences,<br />
University <strong>of</strong> Minnesota, St. Paul, MN.<br />
180<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Room RO8<br />
PLATFORM SESSION: MOLECULAR MECHANISMS OF<br />
OXIDATIVE STRESS<br />
Chairperson(s): Dennis Petersen, University <strong>of</strong> Colorado, Denver, CO and<br />
Ramesh Gupta, Murray State University, Hopkinsville, KY.<br />
#1718 1:30 4-HYDROXYNONENAL MODIFICATION OF<br />
MOLECULAR CHAPERONES IN A RAT MODEL<br />
OF CHRONIC ALCOHOLIC LIVER INJURY. D.<br />
L. Carbone 1 , J. A. Doorn 2 , Z. Kiebler 1 and D. R.<br />
Petersen 1 . 1 University <strong>of</strong> Colorado Health Sciences<br />
Center, Denver, CO and 2 University <strong>of</strong> Iowa, Iowa City,<br />
IA.<br />
#1719 1:50 TOXICITY ASSESSMENT OF SILVER<br />
NANOPARTICLES (AG 15, 100 NM) IN<br />
ALVEOLAR MACROPHAGES. S. Hussain 1 , K.<br />
Hess 2 , J. M. Gearhart 1 , K. T. Geiss 3 and J. M.<br />
Schlager 3 . 1 Mantech Environment Technology, Inc.,<br />
Wright-Patterson AFB, Dayton, OH, 2 Geo-Centers, Inc.,<br />
Wright-Patterson AFB, Dayton, OH and 3 Human<br />
Effectiveness Directorate, Wright-Patterson AFB, OH.<br />
#1720 2:10 LIPIDOMIC ANALYSIS OF THE EFFECT OF<br />
INHIBITION OF CA 2+ -INDEPENDENT<br />
PHOSPHOLIPASE A 2 ON OXIDANT-INDUCED<br />
NEURONAL CELL DEATH. B. Peterson, K. Guthrie<br />
and B. S. Cummings. Pharmacology and Biomed.<br />
Sciences., University <strong>of</strong> Georgia, Athens, GA.<br />
#1721 2:30 IDENTIFICATION AND CHARACTERIZATION<br />
OF SMALL MOLECULE ACTIVATORS OF THE<br />
ANTIOXIDANT RESPONSE ELEMENT. J. T.<br />
Kern 1 , H. Luesch 2 , P. G. Schultz 2,3 and J. A. Johnson 1 .<br />
1 2 University <strong>of</strong> Wisconsin-Madison, Madison, WI, The<br />
Scripps Research Institute, La Jolla, CA and 3 Genomics<br />
Institute <strong>of</strong> the Novartis Research Foundation, San<br />
Diego, CA.<br />
#1722 2:50 PI3 KINASE/AKT, A SURVIVAL PATHWAY<br />
AGAINST CYP2E1 DEPENDENT TOXICITY. A. A.<br />
Caro and A. I. Cederbaum. Pharmacology and<br />
Biological Chemistry, Mount Sinai School <strong>of</strong> Medicine,<br />
New York. Sponsor: D. Petersen.<br />
#1723 3:10 INHIBITION OF HUMAN MITOCHONDRIAL<br />
ALDEHYDE DEHYDROGENASE BY 4-<br />
HYDROXYNON-2-ENAL AND 4-OXONON-2-<br />
ENAL. J. A. Doorn 1 , T. D. Hurley 2 and D. R.<br />
Petersen 3 . 1 Medicinal and Natural Products Chemistry,<br />
University <strong>of</strong> Iowa, Iowa City, IA, 2 Biochemistry,<br />
Indiana University, Indianapolis, IN and<br />
3 Pharmaceutical Sciences, University <strong>of</strong> Colorado,<br />
Denver, CO.<br />
#1724 3:30 INDUCTION OF OXIDATIVE STRESS IN<br />
HUMAN LUNG CELLS BY THE ESTROGEN<br />
METABOLITE, 4-METHOXYESTRADIOL. Y. J.<br />
Cheng 1 , P. Lin 2 and L. W. Chang 1 . 1 Division <strong>of</strong><br />
Environmental Health and Occupational Medicine,<br />
National Health Research Institutes, Kaoshiung, Taiwan<br />
and 2 Institute <strong>of</strong> <strong>Toxicology</strong>, Chung Shan Medical<br />
University, Taichung, Taiwan.<br />
#1725 3:50 PROTEOMIC IDENTIFICATION OF<br />
NONLETHAL OXIDATIVE INJURY<br />
BIOMARKERS. L. Xie and Q. M. Chen.<br />
Pharmacology, University <strong>of</strong> Arizona, Tucson, AZ.<br />
#1726 4:10 GR-DEFICIENT MICE (GR1(A1NEU)) ARE<br />
SUSCEPTIBLE TO DIQUAT-INDUCED HEPATIC<br />
INJURY. L. K. Rogers, X. Meng, M. S. Augustine, S.<br />
E. Welty and C. V. Smith. Center for Developmental<br />
Pharmacology and <strong>Toxicology</strong>, Columbus Children’s<br />
Research Institute, Columbus, OH.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: ENDOCRINE DISRUPTORS<br />
Chairperson(s): Stephen Safe, Texas A&M University, College Station, TX<br />
and Tammy Stoker, U.S. EPA, Research Triangle Park, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1727 CAN THE HERSHBERGER ASSAY<br />
SPECIFICALLY DETECT AN ANDROGENIC OR<br />
ANTI-ANDROGENIC ACTIVITY OF<br />
CHEMICAL? -RELATIONSHIP BETWEEN IN<br />
VITRO AND IN VIVO ASSAYS-. M. Nakai 1 , S.<br />
Noda 1 , M. Iida 2 , M. Takeyoshi 1 , Y. Minobe 1 , K.<br />
Yamasaki 1 , Y. Yakabe 1 and M. Takahashi 3 . 1 Chemicals<br />
Evaluation and Research Institute, Kitakatsushika-gun,<br />
Japan, 2 Otsuka Pharmceutical Co., Ltd.,, Tokushima,<br />
Japan and 3 Pathology Peer Review Center, Tokyo,<br />
Japan.<br />
#1728 ABILITY OF THE MALE RAT PUBERTAL ASSAY<br />
TO DETECT ENVIRONMENTAL CHEMICALS<br />
THAT ALTER THYROID HORMONE<br />
HOMEOSTASIS. T. E. Stoker, S. C. Laws, J. M.<br />
Ferrell and R. L. Cooper. EB, RTD, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#1729 GENE EXPRESSION PROFILING REVEALS<br />
COMMON TARGETS FOR VARIOUS<br />
ANDROGEN RECEPTOR ANTAGONISTS IN<br />
DEVELOPING FETAL RAT TESTIS. X. Mu, K. Liu<br />
and K. W. Gaido. CIIT Centers for Health Research,<br />
Research Triangle Park, NC.<br />
#1730 APPLICATION OF GENE EXPRESSION<br />
ANALYSIS OF MANNOSE 6-<br />
PHOSPHATE/INSULIN-LIKE GROWTH<br />
FACTOR-II RECEPTOR (M6P/IGF2R) IN<br />
VENTRAL PROSTATE FOR SCREENING OF<br />
CHEMICALS WITH ANDROGEN-MEDIATED<br />
ACTIVITIES IN THE RAT HERSHBERGER<br />
ASSAY. T. Yamada, K. Bando, S. Kawamura, Y. Okuno<br />
and T. Seki. Environmental Health Science Laboratory,<br />
Sumitomo Chemical Company, Ltd.,, Osaka, Japan.<br />
#1731 EFFECTS OF AN ANTIANDROGEN ON<br />
PROTEIN AND GENE PROFILES IN ADULT RAT<br />
TESTES. C. Friry-Santini 1,3 , P. Kennel 1 , D. Rouquie 1 ,<br />
M. Samson 2 , M. Benhamed 3 and R. Bars 1 . 1 Research<br />
Center, Bayer CropScience, Sophia Antipolis, France,<br />
2 Unit 638, INSERM, Nice, France and<br />
3 Unit 407,<br />
INSERM, Oullins, France. Sponsor: N. Carmichael.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 181
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1732 PROTEIN PROFILING OF ANTIANDROGEN<br />
EFFECTS IN THE ADULT RAT VENTRAL<br />
PROSTATE. C. Cayatte 1,3 , C. Pons 1 , J. Guigonis 2 , P.<br />
Kennel 3 , D. Rouquie 3 , R. Bars 3 , B. Rossi 1 and M.<br />
Samson 1 . 1 Unit 638, INSERM, Nice, France, 2 IFR50<br />
Proteomic platform, INSERM, Nice, France and<br />
3 Research Center, Bayer CropScience, Sophia-<br />
Antipolis, France. Sponsor: N. Carmichael.<br />
#1733 THE ENDOCRINE PROFILE OF INTACT<br />
FEMALE RATS ON THE DAY OF PROESTRUS<br />
FOLLOWING EXPOSURE TO ATRAZINE. R. L.<br />
Cooper, A. Buckalew, S. C. Laws and T. E. Stoker.<br />
RTD, NHEERL, ORD, U.S. EPA, Research Triangle<br />
Park, NC.<br />
#1734 ESTROGENICITY OF MIXTURES OF<br />
CHEMICALS ON UTERINE GROWTH OF<br />
PREPUBERAL RATS. J. V. Meeuwen 1 , A. Piersma 2 ,<br />
M. van den Berg 1 and J. Sanderson 1 . 1 Biotoxicology,<br />
IRAS, Utrecht, Netherlands and 2 RIVM, Bilthoven,<br />
Utrecht, Netherlands.<br />
#1735 MOLECULAR CHARACTERIZATION OF THE<br />
UTEROTROPHIC ASSAY: TEMPORAL GENE<br />
EXPRESSION CHANGES IN THE UTERUS<br />
FOLLOWING ETHINYLESTRADIOL. H. J. Ahr,<br />
H. Ellinger-Ziegelbauer, A. Freyberger, E. Hartmann, A.<br />
Mahringer and F. Kroetlinger. Molecular and Genetic<br />
<strong>Toxicology</strong>, Bayerhealthcare AG, Wuppertal, Germany.<br />
#1736 COMPARATIVE GENE EXPRESSION ANALYSIS<br />
OF THE MOLECULAR EFFECTS OF<br />
SYNTHETIC, PLANT-DERIVED AND<br />
PHYSIOLOGICAL ESTROGENS IN THE<br />
IMMATURE RODENT UTERUS. J. G. Moggs, H.<br />
Tinwell, F. Lim, M. J. David, I. Kimber, J. Ashby and<br />
O. George. Syngenta CTL, Macclesfield, Cheshire,<br />
United Kingdom.<br />
#1737 ESTRADIOL PROTECTS AGAINST ETHANOL-<br />
INDUCED BONE LOSS IN FEMALE RATS BY<br />
PREVENTING OSTEOCLAST ACTIVATION. R.<br />
Haley 2 , M. Hidestrand 1,2 , K. Shankar 1,2 , C. K.<br />
Lumpkin 3 , B. Yarberry 2 , T. M. Badger 4,2 and M. J.<br />
Ronis 1,2 . 1 Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong><br />
Arkansas for Medical Sciences, Little Rock, AR,<br />
2 Arkansas Children’s Nutrition Center, Little Rock, AR,<br />
3 Pediatrics, University <strong>of</strong> Arkansas for Medical<br />
Sciences, Little Rock, AR and 4 Physiology &<br />
Biophysics, University <strong>of</strong> Arkansas for Medical<br />
Sciences, Little Rock, AR.<br />
#1738 ONTOGENY OF P-GLYCOPROTEIN (PGP) IN<br />
SELECTED TISSUES OF NEONATAL MALE AND<br />
FEMALE CD-1 MICE. S. Yavanhxay 1 , M. Christian 2 ,<br />
A. Hoberman 2 , J. C. Eldridge 1 and J. T. Stevens 1 .<br />
1 Physiology and Pharmacology, Wake Forest University<br />
School <strong>of</strong> Medicine, Winston-Salem, NC and 2 Charles<br />
Rivers Labs, Horsham, PA.<br />
#1739 TRANSCRIPT PROFILING OF GENE<br />
EXPRESSION CHANGES ASSOCIATED WITH<br />
AN INCREASED INCIDENCE OF CANCER<br />
AFTER EXPOSURE OF NEONATAL MICE TO<br />
XENOESTROGENS. D. J. Moore, F. Lim, H. Tinwell,<br />
I. Kimber, J. Ashby, G. Orphanides and J. Moggs.<br />
Syngenta CTL, Macclesfield, Cheshire, United<br />
Kingdom.<br />
#1740 THYROID HORMONE STATUS IN ADULT<br />
FEMALE RATS AFTER AN ORAL DOSE OF<br />
PERFLUOROOCTANESULFONATE (PFOS). J.<br />
Butenh<strong>of</strong>f 1 , M. Eastvold 2 , J. Bjork 3 , D. Ehresman 1 , R.<br />
Singh 2 , K. Wallace 3 and S. Tanaka 1 . 1 3M Company, St.<br />
Paul, MN, 2 Mayo Medical Laboratories, Rochester, MN<br />
and 3 University <strong>of</strong> Minnesota, Duluth, MN.<br />
#1741 THE EFFECTS OF POLYCHLORINATED<br />
BIPHENYLS ON THYROID HORMONE<br />
RECEPTOR MEDIATED ACTION IN VIVO AND<br />
IN VITRO. K. J. Gauger, S. Giera and R. Zoeller.<br />
Biology Department, <strong>Program</strong> in Molecular and<br />
Cellular Biology, University <strong>of</strong> Massachusetts, Amherst,<br />
MA.<br />
#1742 COMPARISON OF INHIBITORY EFFECTS OF<br />
ETHANOL AND METHYL T-BUTYL ETHER<br />
(MTBE) ON RAT LEYDIG CELL<br />
TESTOSTERONE PRODUCTION. R. Shuto, B. B.<br />
Goldberg and A. de Peyster. Graduate School <strong>of</strong> Public<br />
Health, San Diego State University, San Diego, CA.<br />
#1743 CHANGES IN FETAL TESTIS GENE<br />
EXPRESSION AND STEROID HORMONE<br />
SYNTHESIS INDUCED IN MALE OFFSPRING<br />
AFTER MATERNAL TREATMENT WITH DEHP<br />
(DI-N-ETHYLHEXYL PHTHALATE). V. S. Wilson 1 ,<br />
C. Lambright 1 , J. Furr 1 , K. Bobseine 1 , C. Wood 1 , K.<br />
Hosdeshell 2 and L. E. Gray 1 . 1 Reproductive <strong>Toxicology</strong><br />
Division, U.S. EPA, ORD, NHEERL, Research Triangle<br />
Park, NC and 2 NC State University, Raleigh, NC.<br />
#1744 MECHANISM OF PHTHALATE-INDUCED<br />
DEVELOPMENTAL REPRODUCTIVE<br />
TOXICITY: INHIBITION OF TESTOSTERONE<br />
AND INSULIN-LIKE 3 HORMONE<br />
PRODUCTION BY FETAL LEYDIG CELLS. L. E.<br />
Gray, N. Noriega, C. Lambright, J. Furr and V. S.<br />
Wilson. ORD, NHEERL, RTD, EB, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1745 REPRODUCTIVE SUCCESS AND AROMATASE<br />
ACTIVITY IN THE FISH CUNNER<br />
(TAUTOGOLABRUS ADSPERSUS) EXPOSED TO<br />
ATRAZINE OR OCTYLPHENOL IN THE<br />
LABORATORY. L. J. Mills 1 , R. E. Gutjahr-Gobell 1 , S.<br />
C. Laws 2 , D. Borsay Horowitz 1 and G. E. Zaroogian 1 .<br />
1 U.S. EPA, NHEERL, Atlantic Ecology Division,<br />
Narragansett, RI and 2 U.S. EPA, NHEERL,<br />
Reproductive <strong>Toxicology</strong> Division, Research Triangle<br />
Park, NC.<br />
#1746 AROMATASE INHIBITION: LINKING<br />
BIOCHEMICAL MECHANISM OF ACTION TO<br />
OUTCOME IN THE SHORT-TERM FATHEAD<br />
MINNOW REPRODUCTION ASSAY. D. L.<br />
Villeneuve, K. M. Jensen, M. D. Kahl, E. J. Durhan, E.<br />
A. Makynen, A. L. Linnum, B. C. Butterworth and G. T.<br />
Ankley. Mid-Continent Ecology Division, U.S. EPA,<br />
Duluth, MN. Sponsor: J. Mata.<br />
182<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1747 EFFECTS OF VARIOUS LACTONE-<br />
DERIVATIVES ON AROMATASE (CYP19)<br />
ACTIVITY IN H295R HUMAN<br />
ADRENOCORTICAL CARCINOMA CELLS AND<br />
(ANTI)ANDROGENICITY IN TRANSFECTED<br />
LNCAP HUMAN PROSTATE CANCER CELLS. T.<br />
Sanderson 1 , S. Nijmeijer 1 , D. Scholten 1 , M. van den<br />
Berg 1 , S. Cowell 2 , E. Guns 2 , C. Nelson 2 and S.<br />
Ruchirawat 3 . 1 Institute for Risk Assessment Sciences,<br />
Utrecht University, Utrecht, NL, Netherlands, 2 The<br />
Prostate Centre, Vancouver General Hospital,<br />
Vancouver, BC, Canada and 3 Laboratory <strong>of</strong> Medicinal<br />
Chemistry, Chulabhorn Research Institute, Bangkok,<br />
Thailand.<br />
#1748 IN VITRO EFFECTS OF BROMINATED FLAME<br />
RETARDANTS ON THE ADRENOCORTICAL<br />
ENZYME CYP17. A NOVEL ENDOCRINE<br />
MECHANISM OF ACTION? R. Fernandez Canton 1 ,<br />
T. Sanderson 1 , S. Nijmeijer 1 , A. Bergman 2 and M. van<br />
den Berg 1 . 1 Institute for Risk Assessment Sciences,<br />
IRAS, Utrecht, Netherlands and 2 Department <strong>of</strong><br />
Environmental Chemistry and Analytical Chemistry.<br />
Stockholm University, Stockholm, Sweden.<br />
#1749 ESTROGENIC ACTIVITY OF THE<br />
POLYBROMINATED DIPHENYL ETHERS<br />
FLAME RETARDANTS. M. Mercado Feliciano 1 and<br />
R. M. Bigsby 2 . 1 Pharmacology and <strong>Toxicology</strong>, Indiana<br />
University School <strong>of</strong> Medicine, Indianapolis, IN and<br />
2 Obstetrics and Gynecology, Indiana University School<br />
<strong>of</strong> Medicine, Indianapolis, IN. Sponsor: L. Kamendulis.<br />
#1750 SCREENING ASSAYS FOR ANDROGENIC<br />
ACTIVITIES OF XENOBIOTICS. S. O. Mueller and<br />
S. Simon. <strong>Toxicology</strong>, Merck KGaA, Darmstadt,<br />
Germany.<br />
#1751 EVALUATION OF POTENTIAL ESTROGENIC<br />
AND ANDROGENIC ACTIVITY OF<br />
OCTAMETHYLCYCLOTETRASILOXANE (D4)<br />
AND DECAMETHYLCYCLOPENTASILOXANE<br />
(D5). A. L. Quinn, S. D. Cr<strong>of</strong>oot, J. M. Tobin, J. M.<br />
Regan, J. M. McMahon and K. P. Plotzke. Dow Corning<br />
Corporation, Midland, MI.<br />
#1752 ESTROGENIC ENDOCRINE DISRUPTOR<br />
POTENCY OF ORGANOCHLORINE<br />
PESTICIDES DETECTED USING THE LUMI-<br />
CELL TM ER BIOASSAY. J. D. Gordon 1 , A. C. Chu 1 ,<br />
M. D. Chu 2 , M. S. Denison 3 and G. C. Clark 1 .<br />
1 Xenobiotic Detection Systems, Inc., Durham, NC,<br />
2 Alta Analytical PerspectivesInc., Wilmington, NC and<br />
3 Department <strong>of</strong> Environmental <strong>Toxicology</strong>, University<br />
<strong>of</strong> California, Davis, Davis, CA.<br />
#1753 SENSITIVE METHOD FOR DETERMINING<br />
PESTICIDE ESTROGENIETY AT PICOMOLAR<br />
LEVELS USING A SERUM-FREE BG-1 OVARIAN<br />
CELL MODEL. P. Wong and F. Matsumura. Ctr for<br />
Health and the Environment, UC Davis, Davis, CA.<br />
#1754 GENE EXPRESSION PATTERNS OF THE<br />
AMPHIBIAN HPT-AXIS IN NORMAL<br />
DEVELOPMENT AND AFTER EXPOSURE TO<br />
THE MODULATORS METHIMAZOLE,<br />
PERCHLORATE AND PROPYLTHIOURACIL. J.<br />
J. Korte, H. M. Kerr, S. L. Batterman, G. W. Holcombe,<br />
P. A. Kosian, J. E. Tietge and S. J. Degitz. MED,<br />
NHEERL, ORD, U.S. EPA, Duluth, MN. Sponsor: J.<br />
Nichols.<br />
#1755 PROTEIN PROFILING OF XENOPUS LAEVIS<br />
BRAIN CELLS FOLLOWING EXPOSURE TO T4<br />
SYNTHESIS INHIBITORS: POTENTIAL<br />
APPLICATION TO THE<br />
ASSESSMENT/DIAGNOSIS OF XENOBIOTICS<br />
THAT PERTURB THE THYROID PATHWAY. J.<br />
Serrano 1 , B. Witthuhn 2 , L. Higgings 2 , J. Tietge 1 , J.<br />
Korte 1 , P. Kosian 1 , G. Holcombe 1 and S. Degitz 1 .<br />
1 ORD/NHEERL/MED, U.S. EPA, Duluth, MN and<br />
2 Biochemistry and Molecular Biology, University <strong>of</strong><br />
Minnesota, St. Paul, MN. Sponsor: J. Nichols.<br />
#1756 PHENOBARBITAL AFFECTS THYROID<br />
HISTOLOGY AND LARVAL DEVELOPMENT IN<br />
THE AFRICAN CLAWED FROG, XENOPUS<br />
LAEVIS. M. J. Chowdhury, G. W. Holcombe, P. A.<br />
Kosian, J. E. Tietge and S. J. Degitz. Mid-Continent<br />
Ecology Division, U.S. EPA, Duluth, MN. Sponsor: J.<br />
Nichols.<br />
#1757 SUBLETHAL EFFECTS OF CADMIUM ON<br />
DEVELOPMENT IN RANA PIPIENS AND<br />
XENOPUS TROPICALIS. J. A. Gross 1,2 , T. Chen 2 and<br />
W. H. Karasov 2 . 1 Animal Sciences, University <strong>of</strong><br />
Wisconsin–Madison, Madison, WI and 2 Wildlife<br />
Ecology, University <strong>of</strong> Wisconsin–Madison, Madison,<br />
WI.<br />
#1758 MECHANISMS OF GERMINAL VESICLE<br />
BREAKDOWN (GVBD) INHIBITION BY<br />
PHENYL-SUBSTITUTED GLYCOL ETHERS IN<br />
XENOPUS OOCYTES IN VITRO. D. J. Fort 1 , R. L.<br />
Rogers 1 , J. H. Thomas 1 , P. D. Guiney 2 and J. A. Weeks 2 .<br />
1 Fort Environmental Laboratories, Stillwater, OK and<br />
2 Product Safety & Environmental Assessment, SC<br />
Johnson & Son, Racine, WI.<br />
#1759 NON-ADDITIVE DOSE DEPENDENT GENE<br />
EXPRESSION PATTERNS EXHIBITED BY A<br />
MIXTURE OF 17-ALPHA ETHYNYLESTRADIOL<br />
AND GENISTEIN IN VIVO. R. Gupta 2,3,4 , L. D.<br />
Burgoon 1,3,4 , A. Harney 2,3,4 , D. R. Boverh<strong>of</strong> 2,3,4 , J.<br />
Kwekel 2,3,4 , C. Gennings 5 and T. R. Zacharewki 2,3,4 .<br />
1 Pharmacology & <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI, 2 Biochemistry &<br />
Molecular Biology, Michigan State University, East<br />
Lansing, MI, 3 Center for Integrative <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI, 4 National<br />
Food Safety & <strong>Toxicology</strong> Center, Michigan State<br />
University, East Lansing, MI and 5 Biostatistics, Virginia<br />
Commonwealth University, Richmond, VA.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 183
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: STEROID RECEPTORS<br />
Chairperson(s): Timothy Zacharewski, Michigan State University, East<br />
Lansing, MI.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1760 TEMPORAL GENE EXPRESSION ANALYSIS OF<br />
MOUSE HEPA-1C1C7 CELLS TREATED WITH<br />
17β-ESTRADIOL BY CDNA MICROARRAY. C. J.<br />
Fong, L. D. Burgoon, R. Gupta, D. G. Humes and T. R.<br />
Zacharewski. Biochemistry and Molecular Biology,<br />
Michigan State University, East Lansing, MI.<br />
#1761 CONSTITUTIVE ANDROSTANE RECEPTOR<br />
(CAR)-DEPENDENT HEPATIC INDUCTION OF<br />
UDP-GLUCURONOSYLTRANSFERASES (UGTS)<br />
IN WISTAR-KYOTO RATS BY CYP2B<br />
INDUCERS. M. K. Shelby 1 , A. L. Slitt 1 , N. J.<br />
Cherrington 2 and C. D. Klaassen 1 . 1 University <strong>of</strong><br />
Kansas Medical Center, Kansas City, KS and<br />
2 University <strong>of</strong> Arizona, Tucson, AZ.<br />
#1762 HEPATIC INDUCTION OF MOUSE UDP-<br />
GLUCURONOSYLTRANSFERASE (UGT) MNRA<br />
EXPRESSION BY PROTOTYPICAL<br />
ACTIVATORS OF VARIOUS TRANSCRIPTION<br />
PATHWAYS. D. B. Buckley, J. S. Petrick and C. D.<br />
Klaassen. University <strong>of</strong> Kansas Medical Center, Kansas<br />
City, KS.<br />
#1763 INDUCIBILITY OF MOUSE TRANSCRIPTION<br />
FACTORS THAT REGULATE HEPATIC<br />
METABOLISM AND TRANSPORT. J. S. Petrick, D.<br />
B. Buckley and C. D. Klaassen. University <strong>of</strong> Kansas<br />
Medical Center, Kansas City, KS.<br />
#1764 VITAMIN D-INTERACTING PROTEIN 150<br />
(DRIP150) COACTIVATION OF ESTROGEN<br />
RECEPTOR α (ERα) IN ZR-75 BREAST CANCER<br />
CELLS IS INDEPENDENT OF LXXLL MOTIFS. J.<br />
Lee 1 , K. Kim 1 and S. Safe 1,2 . 1 Veterinary Physiology &<br />
Pharmacology, Texas A&M University, College Station,<br />
TX and 2 Institute <strong>of</strong> Biosciences & Technology, Texas<br />
A&M University System Health Science Center,<br />
Houston, TX.<br />
#1765 GLUCOCORTICOID RECEPTOR AND STEROID<br />
AND XENOBIOTIC RECEPTOR (SXR)<br />
REGULATION OF SXR PROMOTER ACTIVITY.<br />
L. M. Tompkins and A. D. Wallace. Environmental and<br />
Molecular <strong>Toxicology</strong>, North Carolina State University,<br />
Raleigh, NC.<br />
#1766 HEPATOCYTE RXRALPHA REGULATES THE<br />
EXPRESSION OF THE GLUTATHIONE S-<br />
TRANSFERASE GENES AND MODULATES<br />
ACETAMINOPHEN-GLUTATHIONE<br />
CONJUGATION IN MOUSE LIVER. Y. Y. Wan, N.<br />
Chou, L. He, M. Gyamfi, A. J. Mendy and G. Dai.<br />
Pharmacology, <strong>Toxicology</strong> and Therapeutics, University<br />
<strong>of</strong> Kansas Medical Center, Kansas City, KS.<br />
#1767 P38 MITOGEN-ACTIVATED PROTEIN KINASE<br />
IS INVOLVED IN CONSTITUTIVE<br />
ANDROSTANE RECEPTOR SIGNALING TO<br />
REGULATE CYP2B INDUCTION BY<br />
XENOBIOTICS. F. Zhang, H. B. H<strong>of</strong>fman and L. You.<br />
CIIT, Research Triangle Park, NC.<br />
#1768 EVIDENCE FOR CAR-DEPENDENT<br />
HEPATOCELLULAR PROLIFERATION IN<br />
TCPOBOP-TREATED CONSTITUTIVE<br />
ANDROSTANE RECEPTOR KNOCKOUT (CAR -/-<br />
) MICE. D. M. Nelson, V. Bhaskaran, B. Gemzik, B. D.<br />
Car and L. D. Lehman-McKeeman. Discovery<br />
<strong>Toxicology</strong>, Bristol-Myers Squibb, Princeton, NJ.<br />
#1769 EFFECTS OF 2, 2’, 4, 4, ‘-<br />
TETRABROMODIPHENYL ETHER ON CAR<br />
AND PXR REGULATED GENE EXPRESSION IN<br />
WEANLING FEMALE RATS. V. M. Richardson 1 , K.<br />
M. Cr<strong>of</strong>ton 2,1 and M. J. DeVito 1 .<br />
1 ORD/NHEERL/ETD/PKB, U.S. EPA, Research<br />
Triangle Park, NC and 2 ORD/NHEERL/ETD/NTD,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#1770 TRANSCRIPTIONAL ACTIVATION OF<br />
CREATINE KINASE GENE EXPRESSION BY<br />
INSULIN-LIKE GROWTH FACTOR (IGF-I). F.<br />
Wang 1 and S. Safe 2 . 1 OB/GYN, The State University <strong>of</strong><br />
New York, Buffalo, NY and 2 Veterinary Physiology &<br />
Pharmacology, Texas A&M University, College Station,<br />
TX.<br />
#1771 ANALYSIS OF GENE EXPRESSION DURING<br />
UTERINE INDUCTION AND REGRESSION IN<br />
IMMATURE, OVARIECTOMIZED RATS<br />
FOLLOWING TREATMENT WITH ETHYNYL<br />
ESTRADIOL. J. C. Kwekel, H. A. Dalgleish, L. D.<br />
Burgoon, J. R. Harkema and T. R. Zacharewski.<br />
Department <strong>of</strong> Biochemistry and Molecular Biology,<br />
National Food Safety and <strong>Toxicology</strong> Center, Center for<br />
Integrative <strong>Toxicology</strong>, Michigan State University, East<br />
Lansing, MI.<br />
#1772 EFFECTS OF ESTROGEN ON IMMATURE,<br />
OVARIECTOMIZED MICE: A MULTI-<br />
APPROACH, TISSUE-BY-TISSUE COMPARISON.<br />
J. W. Burt 1,2 , L. D. Burgoon 2 , D. G. Humes 1 , J. C.<br />
Kwekel 1,2 , A. S. Harney 1 , J. R. Harkema 3 and T. R.<br />
Zacharewski 1,2 . 1 Biochemistry & Molecular Biology,<br />
Michigan State University, East Lansing, MI, 2 Center<br />
for Integrative <strong>Toxicology</strong>, Michigan State University,<br />
East Lansing, MI and 3 Pathobiology & Diagnostic<br />
Investigation, Michigan State University, East Lansing,<br />
MI.<br />
#1773 REGULATION OF TRANSCRIPTIONAL<br />
ACTIVATION OF LARGEMOUTH BASS<br />
ESTROGEN RECEPTORS ALPHA, BETA 1 AND<br />
BETA 2 BY ESTRADIOL AND THE<br />
CONTAMINANTS NONYLPHENOL AND<br />
METHOXYCHLOR IN HEPG2 CELLS. N.<br />
Denslow 1 , J. Blum 1 and T. Sabo-Attwood 2 . 1 University<br />
<strong>of</strong> Florida, Gainesville, FL and 2 University <strong>of</strong> Vermont,<br />
Burlington, VT.<br />
184<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1774 ESTROGEN INFLUENCES THE GROWTH OF<br />
CELLS THROUGH MODULATING THE<br />
INTRACELLULAR REDOX STATE. Q. Felty and<br />
D. Roy. Environmental & Occupational Health, Florida<br />
International University, Miami, FL.<br />
#1775 THE EFFECT OF POLYCHLORINATED<br />
BIPHENYLS (PCBs) ON THYROID HORMONE<br />
RECEPTOR (TR) AND CO-REGULATOR<br />
INTERACTIONS ON DNA. S. You 1 , K. Gauger 1 and<br />
R. Zoeller 2,1 . 1 Molecular & Cellular Biology <strong>Program</strong>,<br />
University <strong>of</strong> Massachusetts, Amherst, MA and<br />
2 Biology, University <strong>of</strong> Massachusetts, Amherst, MA.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: PHARMACEUTICALS-METABOLIC/CANCER<br />
Chairperson(s): Thomas Mably, Bristol Meyers Squibb Co, Evansville, IN.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1776 GENETIC TOXICOLOGY AND BONE MARROW<br />
CYTOTOXICITY STUDIES OF THE<br />
CORTICOTROPIN-RELEASING HORMONE<br />
(CRH) RECEPTOR ANTAGONIST,<br />
ANTALARMIN. P. T. Curry 1 , M. Nagabhushan 1 , D. L.<br />
McCormick 1 , R. E. Parchment 2 , K. Calis 3 , P. W. Gold 3 ,<br />
G. Cizza 3 , D. Charney 3 , E. R. Glaze 4 and J. E.<br />
Tomaszewski 4 . 1 IIT Research Institute, Chicago, IL,<br />
2 SciTech Development LLC, Grosse Pointe, MI,<br />
3 National Institute <strong>of</strong> Mental Health, Bethesda, MD and<br />
4 National Cancer Institute, Bethesda, MD.<br />
#1777 SUBCHRONIC ORAL TOXICITY OF THE<br />
CORTICOTROPIN-RELEASING HORMONE<br />
(CRH) RECEPTOR ANTAGONIST,<br />
ANTALARMIN, IN DOGS. W. D. Johnson 1 , J.<br />
Harder 1 , D. L. McCormick 1 , R. L. Morrissey 2 , K.<br />
Calis 3 , P. W. Gold 3 , G. Cizza 3 , D. Charney 3 , E. R.<br />
Glaze 4 and J. E. Tomaszewski 4 . 1 IIT Research Institute,<br />
Chicago, IL, 2 Pathology Associates, Chicago, IL,<br />
3 National Institute <strong>of</strong> Mental Health, Bethesda, MD and<br />
4 National Cancer Institute, Bethesda, MD.<br />
#1778 SUBCHRONIC ORAL TOXICITY OF THE<br />
CORTICOTROPIN-RELEASING HORMONE<br />
(CRH) RECEPTOR ANTAGONIST,<br />
ANTALARMIN, IN RATS. T. L. Horn 1 , W. D.<br />
Johnson 1 , D. L. McCormick 1 , R. L. Morrissey 2 , K.<br />
Calis 3 , P. W. Gold 3 , G. Cizza 3 , D. Charney 3 , E. R.<br />
Glaze 4 and J. E. Tomaszewski 4 . 1 IIT Research Institute,<br />
Chicago, IL, 2 Pathology Associates, Chicago, IL,<br />
3 National Institute <strong>of</strong> Mental Health, Bethesda, MD and<br />
4 National Cancer Institute, Bethesda, MD.<br />
#1780 REPEAT DOSE TOXICITY STUDIES IN RATS<br />
AND DOGS WITH TH0318, A DPP IV-RESISTANT<br />
ANALOG OF NATURAL GLP-1. S. Fennell 1 , H.<br />
Loughrey 1 , M. Garino 1 , S. Abdullah 1 , M. Stilianesis 2 ,<br />
K. Arjah 2 , B. Vu 2 and E. Ferdinandi 1 .<br />
1 Theratechnologies, Inc., Saint Laurent (Montreal), QC,<br />
Canada and 2 CTBR Bio-Research Inc., Senneville, QC,<br />
Canada. Sponsor: C. Banks.<br />
#1781 CARCINOGENICITY EVALUATION OF<br />
ATAZANAVIR IN MICE. T. A. Mably 1 , T. P.<br />
Sanderson 1 , C. D. Houle 2 , B. E. Schilling 1 and M. A.<br />
Dominick 1 . 1 Drug Safety Evaluation, Bristol-Myers<br />
Squibb Co., Mt.Vernon, IN and 2 Experimental<br />
Pathology Laboratories, Inc., Research Triangle Park,<br />
NC.<br />
#1782 MULTIPLE DOSE TOXICITY STUDY OF<br />
IMEXON IN FISCHER 344 RATS. Y. Chen 1 , E.<br />
Glaze 2 , J. Tomaszewski 2 , R. Morrissey 3 and A.<br />
Lyubimov 1 . 1 <strong>Toxicology</strong> Research Laboratory,<br />
University <strong>of</strong> Illinois at Chicago, Chicago, IL, 2 Division<br />
<strong>of</strong> Cancer Treatment and Diagnosis, National Cancer<br />
Institute, Bethesda, MD and 3 Pathology Associates<br />
Division, Charles River Laboratories, Chicago, IL.<br />
#1783 SEQUENCE DEPENDENT ANTAGONISM<br />
BETWEEN RALOXIFENE, 5-FLUOROURACIL<br />
AND PEMETREXED. E. Fryar 1 , D. H. Jillian 1 , S. M.<br />
William 2 and B. Donnell 1 . 1 Pharmacology, Howard<br />
University, Washington, DC and 2 Biochemistry, Howard<br />
University, Washington, DC.<br />
#1784 UTILIZATION OF MULTIPLE ENDPOINTS TO<br />
INVESTIGATE DIFFERENTIAL TOXICITY<br />
PRODUCED BY TOPOISOMERASE II<br />
INHIBITORS, DOXORUBICIN AND ETOPOSIDE.<br />
R. T. Dunn, E. S. Galambos, L. Healy, R. Morgan, J.<br />
Yamada, H. Hamadeh, A. Kwok, M. E. Cosenza and C.<br />
Afshari. <strong>Toxicology</strong>, Amgen Inc., Thousand Oaks, CA.<br />
#1785 ORAL TOXICITY STUDY OF A RETINOIC ACID<br />
ANALOGUE, 9-CIS-UAB-30, IN RATS. R.<br />
Krishnaraj 1 , A. Lyubimov 1 , C. Detrisac 2 , I.<br />
Kapetanovic 3 , J. Crowell 3 , W. Brouillette 4 and D.<br />
Muccio 4 . 1 Pharmacology, University <strong>of</strong> Illinois at<br />
Chicago, Chciago, IL, 2 Pathology Associates, Chciago,<br />
IL, 3 National Cancer Institute, Bethesda, MD and<br />
4 Chemistry, University <strong>of</strong> Alabama at Birmingham,<br />
Birmingham, AL.<br />
WEDNESDAY<br />
#1779 CYPROHEPTADINE AND CYCLIZINE INHIBIT<br />
INSULIN SECRETION IN RIN5F CELLS BY<br />
INHIBITING CALCIUM CHANNELS. M. Otieno 1 , N.<br />
Bavuso 1 , A. Katein 1 , T. Kelly 1 , J. Milano 1 and F.<br />
Pognan 2 . 1 Safety Assessment US, AstraZeneca<br />
Pharmaceuticals, Wilmington, DE and 2 Safety<br />
Assessment UK, AstraZeneca Pharmaceuticals, Alderly<br />
Park, United Kingdom.<br />
up-to-date information at www.toxicology.org 185
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: MECHANISMS OF CARCINOGENESIS<br />
Chairperson(s): Michael A. Pereira, Ohio State University, Columbus, OH<br />
and Mark S. Miller, Wake Forest University School <strong>of</strong> Medicine, Winston<br />
Salem, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1786 CHANGES IN THE METHYLATION STATUS OF<br />
GC-RICH REGIONS OF DNA DURING THE<br />
PROMOTION STAGE OF SKIN<br />
TUMORIGENESIS. A. N. Carnell-Bachman 1 , G. M.<br />
Curtin 2 , D. J. Doolittle 2 and J. I. Goodman 1 .<br />
1 Pharmacology and <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI and 2 Research and<br />
Development, R. J. Reynolds Tobacco Company,<br />
Winston-Salem, NC.<br />
#1787 DIETHANOLAMINE (DEA) AND<br />
PHENOBARBITAL (PB) PRODUCE AN ALTERED<br />
PATTERN OF METHYLATION IN GC-RICH<br />
REGIONS OF DNA IN B6C3F1 MOUSE<br />
HEPATOCYTES SIMILAR TO THAT RESULTING<br />
FROM CHOLINE DEFICIENCY. J. I. Goodman 1 , L.<br />
M. Kamendulis 2 and A. N. Carnell-Bachman 1 .<br />
1 Pharmacology and <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI and 2 Pharmacology and<br />
<strong>Toxicology</strong>, Indiana University School <strong>of</strong> Medicine,<br />
Indianapolis, IN.<br />
#1788 DNA HYPOMETHYLATION INDUCED BY<br />
DRINKING WATER DISINFECTION BY-<br />
PRODUCTS IN MOUSE AND RAT KIDNEY. L.<br />
Tao 1 , W. Wang 1 , P. M. Kramer 2 , L. Li 2 and M. A.<br />
Pereira 1,2 . 1 Internal Medicine, Ohio State University,<br />
Columbus, OH and 2 Molecular Biology and<br />
Biochemistry, Medical College <strong>of</strong> Ohio, Toledo, OH.<br />
#1789 LOSS OF HISTONE ACETYLATION BY NICKEL:<br />
AN EPIGENETIC MECHANISM OF NICKEL<br />
CARCINOGENESIS. Q. ke, T. Kluz and M. Costa.<br />
Department <strong>of</strong> Environmental Health, New York<br />
University School <strong>of</strong> Medicine, Nelson Institute,<br />
Tuxedo, NY.<br />
#1790 SEXUAL DIMORPHISM IN DNA METHYLATION<br />
IN THE LIVER OF HEXACHLOROBENZENE-<br />
TREATED RAT : A POSSIBLE MECHANISM<br />
FOR TUMOR PROMOTION. N. J. Raynal, M.<br />
Charbonneau, B. Alt, L. Lee and D. G. Cyr. INRS-<br />
Institut Armand-Frappier, Universite du Quebec, Pointe-<br />
Claire, QC, Canada.<br />
#1791 LOSS OF BRG1 AND LUNG CANCER<br />
PATHOGENESIS. C. Bartlett 1 , G. Rosson 2 and B.<br />
Weissman 2,1 . 1 Curriculum in <strong>Toxicology</strong>, UNC-CH,<br />
Chapel Hill, NC and 2 Pathology and Laboratory<br />
Medicine, UNC-CH, Chapel Hill, NC. Sponsor: C.<br />
Harper.<br />
#1792 SECONDARY GENETIC ALTERATIONS IN<br />
LUNG TUMORS POSSESSING A PRIMARY KI-<br />
RAS MUTATION. H. S. Floyd 1 , J. Jennings-Gee 1 , N.<br />
D. Kock 2 and M. S. Miller 1 . 1 Cancer Biology, Wake<br />
Forest University, Winston-Salem, NC and<br />
2 Comparative Medicine, Wake Forest University,<br />
Winston-Salem, NC.<br />
#1793 COMPARISON OF EXPRESSION PROFILES OF<br />
ENU-INDUCED FORESTOMACH TUMORS AND<br />
URETHANE-INDUCED LUNG TUMORS IN<br />
RASH2 MICE. M. Okamura 1 , A. Unami 2 , Y. Oishi 2 , K.<br />
Sumida 3 , Y. Kashida 1 , N. Machida 1 and K. Mitsumori 1 .<br />
1 Tokyo university <strong>of</strong> agriculture and technology, Tokyo,<br />
Japan, 2 <strong>Toxicology</strong> Research Laboratories, Fujisawa<br />
Pharmaceutical Co., Ltd.,, Osaka, Japan and<br />
3 Environmental Health Science Laboratory, Sumitomo<br />
Chemical Co., Ltd.,, Osaka, Japan. Sponsor: M.<br />
Takahashi.<br />
#1794 CYTOCHROME P4502E1 (CYP2E1) MEDIATED<br />
METABOLISM IS A PRE-REQUISITE FOR THE<br />
PATHOGENESIS OF URETHANE-INDUCED<br />
GENOTOXICITY AND CARCINOGENICITY. U.<br />
H<strong>of</strong>fler 1,2 , D. Dixon 2 , S. Peddada 2 and B. I.<br />
Ghanayem 2,1 . 1 Department <strong>of</strong> Pharmacology, Meharry<br />
Medical College, Nashville, TN and 2 NIEHS/NIH,<br />
Research Triangle Park, NC.<br />
#1795 EFFECTS OF AFB 1 ON EXPRESSION OF P53<br />
AND MDM2 AND ON APOPTOSIS IN HUMAN<br />
LUNG CELLS. T. L. Watterson 1 , T. R. Van Vleet 2 and<br />
R. A. Coulombe 1 . 1 <strong>Toxicology</strong> Graduate <strong>Program</strong>, Utah<br />
State University, Logan, UT and 2 Drug Safety<br />
Evaluation, Bristol-Myers Squibb Company, Mt.<br />
Vernon, IN.<br />
#1796 NOVEL LAVENDAMYCINS AND AB RING<br />
SYSTEM ANALOGUES: IN VITRO<br />
CYTOTOXICITY, APOPTOSIS INDUCTION AND<br />
METABOLISM BY NAD(P)H:QUINONE<br />
OXIDOREDUCTASE 1 (NQO1). M. Hassani 1 , W.<br />
Cai 2 , K. C. Bray 1 , M. Behforouz 2 and H. D. Beall 1 .<br />
1 Center for Environmental Health Sciences, The<br />
University <strong>of</strong> Montana, Missoula, MT and 2 Department<br />
<strong>of</strong> Chemistry, Ball State University, Muncie, IN.<br />
#1797 HIGH PERFORMANCE LIQUID<br />
CHROMATOGRAPHY ASSAY FOR N-<br />
GLUCURONIDATION 4-AMINOBIPHENYL IN<br />
MICE LIVER MICROSOMES AND EXPRESSED<br />
HUMAN SUPERSOMES. M. H. Al-Zoughool.<br />
Environmental Health, University <strong>of</strong> Cincinanti,<br />
Cincinnati, OH.<br />
#1798 URINARY BLADDER ENDPOINTS IN WORKERS<br />
AND RATS EXPOSED TO<br />
PERFLUOROOCTANESULFONYL FLUORIDE<br />
(POSF) AND RELATED COMPOUNDS. G. Olsen 1 ,<br />
B. Alexander 2 , S. Cohen 3 and J. Butenh<strong>of</strong>f 1 . 1 3M<br />
Company, St. Paul, MN, 2 University <strong>of</strong> Minnesota,<br />
Minneapolis, MN and 3 University <strong>of</strong> Nebraska Med.<br />
Ctr., Omaha, NE.<br />
186<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1799 DNA DAMAGE AND CYTOGENETIC EFFECTS<br />
OF OCHRATOXIN A IN RATS IN VIVO. A. Mally 1 ,<br />
G. Pepe 2 , S. Ravoori 3 , M. Fiore 2 , R. C. Gupta 3 , P.<br />
Mosesso 2 and W. Dekant 1 . 1 Department <strong>of</strong> <strong>Toxicology</strong>,<br />
University <strong>of</strong> Wuerzburg, Wuerzburg, Germany,<br />
2 Dipartimento die Agrobiologia e Agrochimica,<br />
Universita degli Studi della Tuscia, Viterbo, Italy and<br />
3 Pharmacology&<strong>Toxicology</strong>, Brown Cancer Center,<br />
University <strong>of</strong> Louisville, Louisville, KY.<br />
#1800 α 2U -GLOBULIN AND RENAL TUMORS IN<br />
NATIONAL TOXICOLOGY PROGRAM (NTP)<br />
STUDIES. A. M. Doi, G. D. Hill, J. R. Hailey and J. R.<br />
Bucher. NTP, NIEHS, Research Triangle Park, NC.<br />
#1801 THE TSC-2 TUMOR SUPPRESSOR GENE<br />
MODULATES MULTIPLE CELL<br />
PROLIFERATION PATHWAYS. M. T. Labenski 1 , X.<br />
Wei 1 , A. Hunt 1 , G. Tsaprailis 1 , M. S. Chacko 2 , M. D.<br />
Person 2 , J. Shen 2 , S. C. Hensley 3 , T. J. Monks 1 and S. S.<br />
Lau 1 . 1 Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong><br />
Arizona, Tucson, AZ, 2 Pharmacology and <strong>Toxicology</strong>,<br />
University <strong>of</strong> Texas at Austin, Austin, TX and<br />
3 UTMDACC, Science Park, Smithville, TX.<br />
#1802 GLOBAL EXPRESSION PROFILING OF MALE<br />
RAT KIDNEY: CO-ADMINISTRATION OF A<br />
SPECIFIC ESTROGEN RECEPTOR (ER)<br />
ANTAGONIST INHIBITS A DYNAMIC 17B-<br />
ESTRADIOL (E2) RESPONSE. P. H. Koza-Taylor 1 ,<br />
G. D. Cappon 4 , J. D. Obourn 3 , J. C. Cook 2 and M. P.<br />
Lawton 1 . 1 MIT, Pfizer, Groton, CT, 2 FD & LS, Pfizer,<br />
Groton, CT, 3 ED, Pfizer, Groton, CT and 4 <strong>Toxicology</strong><br />
Sciences, Pfizer, Groton, CT.<br />
#1803 APOPTOSIS, SENESCENCE AND<br />
CYTODIFFERENTIATION IN CARCINOGENIC<br />
MODELING. N. H. Chiu 4 , G. Merlino 2 , K. H. Kim 3 ,<br />
C. J. Kermp 3 and J. Beaubier 5 . 1 NCEADC, U.S. EPA,<br />
Washington, DC, 2 Lab. Molecular Biology, National<br />
Cancer Institute, Bethesda, MD, 3 Division Human Biol,<br />
Public Health Sciences, Fred Hutchinson Cancer<br />
Research Center, Seattle, WA, 4 Office Science<br />
Technology Office <strong>of</strong> Water, U.S. EPA, Washington, DC<br />
and 5 Office Pesticide Pollution Prevention Toxics, U.S.<br />
EPA, Washington, DC. Sponsor: D. Singh.<br />
#1804 NUMBER OF CRITICAL CELL-CYCLE-EVENTS<br />
IN CANCER DEVELOPMENT OF P53-P27 KO<br />
MICE. N. Chiu 3 , K. H. Kim 2 , C. Kemp 2 and J.<br />
Beaubier 4 . 1 NCEADC, U.S. EPA, Washington DC, DC,<br />
2 Division Human Biology Public Health Sciences, Fred<br />
Hutchindon Cancer Research Center, Seattle, WA,<br />
3 Office Science & Technology, Office <strong>of</strong> Water, U.S.<br />
EPA, Washington, DC and 4 Office Pollution Prevention<br />
and Toxics, U.S. EPA, Washington, DC. Sponsor: D.<br />
Singh.<br />
#1805 ARNT, A PUTATIVE COACTIVATOR OF C-<br />
MYC/MAX SIGNALING PATHWAY, INTERACTS<br />
WITH C-MYC. R. wu, M. Hoagland and H. Swanson.<br />
University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1806 A POTENTIAL ROLE FOR C-MYB, BAX AND<br />
THE ARYL HYDROCARBON RECEPTOR IN<br />
BENZENE-INITIATED TOXICITY. H. J. Badham 1<br />
and L. M. Winn 1,2 . 1 Pharmacology and <strong>Toxicology</strong>,<br />
Queen’s University, Kingston, ON, Canada and 2 School<br />
<strong>of</strong> Environmental Studies, Queen’s University,<br />
Kingston, ON, Canada.<br />
#1807 THE ESTROGENIC ACTIVITIES OF ARYL<br />
HYDROCARBON RECEPTOR AGONISTS ARE<br />
DUE TO DIRECT ACTIVATION OF ESTROGEN<br />
RECEPTOR α M. Abdelrahim 1 , K. Kim 2 , S. Pearce 3 ,<br />
E. Ariazi 3 , H. Liu 3 , V. Jordan 3 and S. Safe 1,2 . 1 Institute<br />
<strong>of</strong> Biosciences & Technology, Texas A&M University<br />
System Health Science Center, Houston, TX,<br />
2 Veterinary Physiology & Pharmacology, Texas A&M<br />
University, College Station, TX and 3 Robert H. Lurie<br />
Comprehensive Cancer Center, Northwestern<br />
University, Chicago, IL.<br />
#1808 INHIBITION OF ESTROGEN RECEPTOR-<br />
NEGATIVE BREAST CANCER CELL GROWTH<br />
BY ARYL HYDROCARBON RECEPTOR<br />
AGONISTS. L. Kotha and S. Safe. Veterinary<br />
Physiology & Pharmacology, Texas A&M University,<br />
College Station, TX.<br />
#1809 CONSEQUENCES OF INTERACTION OF THE<br />
EQUINE ESTROGEN METABOLITE, 4-<br />
HYDROXYEQUILENIN, WITH ESTROGEN<br />
RECEPTOR α M. Chang and J. L. Bolton. University<br />
<strong>of</strong> Illinois at Chicago, Chicago, IL.<br />
#1810 G2/M BLOCK OF PRIMARY MAMMARY<br />
EPITHELIAL CELLS FROM PRE-MENOPAUSAL<br />
WOMEN IN RESPONSE TO GENOTOXIC<br />
CARCINOGEN EXPOSURE. J. Brooks 1 , J. Wang 1 ,<br />
A. Humphrey 1 , J. Hearnes 2 , J. Pietenpol 2 , J. Price 2 and<br />
S. E. Eltom 1 . 1 Pharmacology, Meharry Medical College,<br />
Nashville, TN and 2 Vanderbilt University, Nashville,<br />
TN.<br />
#1811 CHANGES IN ESTROGEN METABOLISM IN<br />
CATECHOL-O-METHYLTRANSFERASE (COMT)<br />
DEFICIENT MICE ARE ASSOCIATED WITH<br />
INCREASED DEVELOPMENT AND ALTERED<br />
GENE EXPRESSION IN THE MOUSE<br />
MAMMARY GLAND. C. Borgeest 1 , C. A. Zahnow 2 ,<br />
S. O. DaCosta 1 , B. L. McAtee 1 , J. A. Flaws 3 , J. K.<br />
Babus 3 , S. Biswal 1 and J. D. Yager 1 . 1 Environmental<br />
Health Science, Johns Hopkins University, Baltimore,<br />
MD, 2 Cancer Biology, Johns Hopkins University,<br />
Baltimore, MD and 3 Department <strong>of</strong> Epidemiology and<br />
Preventive Medicine, University <strong>of</strong> Maryland,<br />
Baltimore, MD.<br />
#1812 INVESTIGATION OF<br />
OCTAMETHYLCYCLOTETRASILOXANE (D4)<br />
AND DECAMETHYLCYCLOPENTASILOXANE<br />
(D5) AS DOPAMINE D2-RECEPTOR AGONISTS.<br />
P. A. Jean, K. A. McCracken, J. A. Arthurton and K. P.<br />
Plotzke. Dow Corning Corporation, Midland, MI.<br />
#1813 TRANSPLACENTAL AND POSTNATAL<br />
EXPOSURE OF AIDS DRUGS ZIDOVUDINE<br />
(AZT) AND LAMIVUDINE (3TC) IN<br />
C3B6F 1 TRP53(+/-) TRANSGENIC MICE. F. W. Lee,<br />
S. M. Lewis, C. Crawford, W. T. Allaben and J. E.<br />
Leakey. U.S. FDA, NCTR, Jefferson, AR.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 187
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1814 EFFECT OF A COMPLEX MIXTURE FROM<br />
COAL TAR–SRM 1597 ON THE METABOLIC<br />
ACTIVATION OF CARCINOGENIC<br />
POLYCYCLIC AROMATIC HYDROCARBONS IN<br />
CHINESE HAMSTER V79 CELLS. B. Mahadevan 1 ,<br />
C. P. Marston 1 , W. Dashwood 1 , E. Brooks 1 , Y. Li 2 , C.<br />
Pereira 2 , J. Doehmer 3 and W. M. Baird 1 . 1 Environmental<br />
and Molecular <strong>Toxicology</strong>, Oregon State University,<br />
Corvallis, OR, 2 Department <strong>of</strong> Statistics, Oregon State<br />
University, Corvallis, OR and 3 GenPharm <strong>Toxicology</strong><br />
BioTechAG, Martinsried, Germany.<br />
#1815 COMPETING ROLES OF ALDO-KETO<br />
REDUCTASE 1A1 AND CYP1A1/CYP1B1 IN THE<br />
METABOLIC ACTIVATION OF (+/-)-<br />
BENZO(A)PYRENE-7, 8-DIOL IN HUMAN<br />
BRONCHOALVEOLAR CELLS: INFLUENCE OF<br />
CYP INDUCTION. H. Jiang, D. Vudathala, I. A. Blair<br />
and T. M. Penning. Department <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Pennsylvania School <strong>of</strong> Medicine,<br />
Philadelphia, PA. Sponsor: S. Burchiel.<br />
#1816 COMPARISON OF GENE EXPRESSION IN<br />
KIDNEY AND URINARY BLADDER FROM RATS<br />
TREATED WITH DIMETHYLARSINIC ACID. K.<br />
Bailey 1 , S. D. Hester 1 , A. Wang 2 , J. L. Robertson 2 , D.<br />
C. Wolf 1 and B. Sen 1 . 1 Environmental Carcinogenesis<br />
Division, U.S. EPA, Research Triangle Park, NC and<br />
2 Department <strong>of</strong> Biomed Sciences and Path, VA-MD<br />
Regional College <strong>of</strong> Vet. Med., Blacksburg, VA.<br />
#1817 SPECIATION OF ARSENIC IN THE MATERNAL<br />
AND FETAL MOUSE TISSUES FOLLOWING<br />
GESTATIONAL EXPOSURE TO ARSENITE. V.<br />
Devesa 1 , B. Adair 2 , J. Liu 3 , M. Styblo 1,4 , M. P. Waalkes 3<br />
and D. J. Thomas 2 . 1 CEMALB, University <strong>of</strong> North<br />
Carolina at Chapel Hill, Chapel Hill, NC, 2 U.S. EPA,<br />
Research Triangle Park, NC, 3 NCI at NIEHS, Research<br />
Triangle Park, NC and 4 Pediatrics, UNC, Chapel Hill,<br />
NC.<br />
#1818 UPTAKE OF INORGANIC AND ORGANIC<br />
DERIVATIVES OF ARSENIC AND ASSOCIATION<br />
WITH GENOTOXIC EFFECTS IN MAMMALIAN<br />
CELLS IN VITRO. E. Dopp 1 , L. M. Hartmann 2 , A. M.<br />
Florea 1 , U. V. von Recklinghausen 1 , U. Rauen 3 , A. W.<br />
Rettenmeier 1 and A. V. Hirner 2 . 1 Institute <strong>of</strong> Hygiene<br />
and Occupational Medicine, University <strong>of</strong> Duisburg-<br />
Essen, Essen, NRW, Germany, 2 Institute <strong>of</strong><br />
Environmental Chemistry, University <strong>of</strong> Duisburg-<br />
Essen, Essen, Germany and 3 Institute <strong>of</strong> Physiological<br />
Chemistry, University <strong>of</strong> Duisburg-Essen, Essen,<br />
Germany. Sponsor: E. Nelson.<br />
#1819 GENE EXPRESSION ANALYSIS TO IDENTIFY<br />
INTERSPECIES CONCORDANCE OF THE<br />
MECHANISMS OF ARSENIC-INDUCED<br />
BLADDER CANCER. B. Sen 1 , R. Grindstaff 1 , Y.<br />
Turpaz 2 , J. Retief 2 and D. C. Wolf 1 . 1 Environmental<br />
Carcinogenesis Division, U.S. EPA, Research Triangle<br />
Park, NC and 2 Affymetrix, Santa Clara, CA.<br />
#1820 PEROXISOME PROLIFERATOR-ACTIVATED<br />
RECEPTOR β (PPARβ) SUPPRESSES<br />
ANGIOGENESIS. A. D. Burdick 1 , A. N. Billin 2 , T. M.<br />
Willson 2 and J. M. Peters 1 . 1 Department <strong>of</strong> Veterinary<br />
Science, Center for Molecular <strong>Toxicology</strong> and<br />
Carcinogenesis, The Pennsylvania State University,<br />
University Park, PA and 2 Discovery Research,<br />
GlaxoSmithKline, Research Triangle Park, NC.<br />
#1821 IMMUNOHISTOCHEMICAL ANALYSIS OF<br />
EXOCRINE PANCREATIC TOXICITY INDUCED<br />
BY 2, 3, 7, 8-TETRACHLORODIBENZO-P-<br />
DIOXIN IN FEMALE HARLAN SPRAGUE-<br />
DAWLEY RATS. T. Marsh, J. F. Foley, A. Nyska, B.<br />
Cai, S. Peddada, N. J. Walker and K. Yoshizawa.<br />
NIEHS, Research Triangle Park, NC.<br />
#1822 INCREASED MITOCHONDRIAL GLUTATHIONE<br />
CONTENT ENHANCES APOPTOSIS IN NRK-52E<br />
CELLS INDUCED BY THE DNA ALKYLATING<br />
AGENT CISPLATIN. L. H. Lash 1 , F. Xu 1 and L. H.<br />
Matherly 2,1 . 1 Pharmacology, Wayne State University<br />
Sch. Med., Detroit, MI and 2 Karmanos Cancer Institute,<br />
Wayne State University Sch. Med., Detroit, MI.<br />
#1823 CISPLATIN REDUCES VIABILITY, BUT NOT<br />
HEAT SHOCK PROTEIN LEVELS IN RAT<br />
KIDNEY CELLS. J. A. Flaws 1 , J. K. Babus 1 , M.<br />
Lipsky 2 and B. Fowler 3 . 1 Department <strong>of</strong> Epidemiology,<br />
University <strong>of</strong> Maryland, Baltimore, MD, 2 Department<br />
<strong>of</strong> Pathology, University <strong>of</strong> Maryland, Baltimore, MD<br />
and 3 Division <strong>of</strong> <strong>Toxicology</strong>, ATSDR, Atlanta, GA.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: CARDIOVASCULAR DISEASE I–GENE<br />
EXPRESSION<br />
Chairperson(s): Christopher States, University <strong>of</strong> Louisville, Louisville, KY<br />
and Ellen Silbergeld, Johns Hopkins, Baltimore, MD.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1824 TCDD-INDUCED GENE EXPRESSION CHANGES<br />
IN DEVELOPING ZEBRAFISH HEARTS. S. A.<br />
Carney 1 , C. Burns 2,3 , R. E. Peterson 1 and W.<br />
Heideman 1 . 1 University <strong>of</strong> Wisconsin, Madison, WI,<br />
2 Massachusetts General Hospital, Charlestown, MA and<br />
3 Harvard Medical School, Boston, MA.<br />
#1825 CHARACTERIZATION OF TCDD<br />
CARDIOTOXICITY IN EMBRYONIC<br />
ZEBRAFISH. D. S. Antkiewicz, R. E. Peterson and W.<br />
Heideman. University <strong>of</strong> Wisconsin, Madison, WI.<br />
#1826 STUDIES TO IDENTIFY GENE CHANGES IN<br />
THE HEART DURING RECOVERY FROM<br />
HEART TOXICITY INDUCED BY BIS(2-<br />
CHLOROETHOXY)METHANE. J. Dunnick 1 , J.<br />
Parker 2 , P. Blackshear 3 and A. Nyska 1 . 1 Laboratory <strong>of</strong><br />
Experimental Pathology, NIEHS, Research Triangle<br />
Park, NC, 2 Constella Group, Inc., Research Triangle<br />
Park, NC and 3 Integrated Laboratory System, Inc.,<br />
Research Triangle Park, NC.<br />
188<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1827 INCREASED GENE EXPRESSION AND LEVELS<br />
OF ANTIOXIDANTS AND PHASE 2 ENZYMES IN<br />
CARDIAC CELLS TREATED WITH 3H-1, 2-<br />
DITHIOLE-3-THIONE: PROTECTION AGAINST<br />
OXIDANT AND ELECTROPHILE-INDUCED<br />
CELL INJURY. Z. Cao 1,2 , H. Zhu 1 , D. Hardej 1 , L. D.<br />
Trombetta 1 and Y. Li 1 . 1 Pharmaceutical Sciences, St.<br />
John’s University, Jamaica, NY and 2 Harvard Medical<br />
School, Boston, MA.<br />
#1828 DIFFERENTIAL GENE EXPRESSION IN<br />
MICRODISSECTED MESENTERIC VASCULAR<br />
ELEMENTS OF RATS 1-HOUR FOLLOWING<br />
FENOLDOPAM (SKF-82526) ADMINISTRATION.<br />
D. A. Dalmas 1 , M. S. Scicchitano 1 , Y. Chen 2 , H. Olsen 2 ,<br />
L. A. Tierney 1 , P. K. Narayanan 1 , H. C. Thomas 1 , R. W.<br />
Boyce 1 , S. Clark 2 and L. W. Schwartz 1 . 1 Safety<br />
Assessment, GlaxoSmithKline (GSK), King <strong>of</strong> Prussia,<br />
PA and 2 Transcriptome Analysis, GSK, Collegeville,<br />
PA.<br />
#1829 GENOMIC ANALYSIS OF THE MECHANISM OF<br />
CYCLOPHOSPHAMIDE-INDUCED<br />
CARDIOTOXICITY IN RATS: COMPARISON<br />
WITH HUMAN CASES OF MYOCARDITIS. K. K.<br />
Daniels, M. S. Orr and W. B. Mattes. Toxicogenomics,<br />
Gene Logic Inc., Gaithersburg, MD.<br />
#1830 A RAT HEART GENE-EXPRESSION SIGNATURE<br />
PREDICTIVE OF HERG POTASSIUM CHANNEL<br />
BINDING. X. Xu, R. J. Brennan, G. Napolitano and K.<br />
Kolaja. Chemogenomics and <strong>Toxicology</strong>, Iconix<br />
Pharmaceuticals Inc., Mountain View, CA.<br />
#1831 AHR AND ARNT SPECIFICALLY BIND<br />
PUTATIVE DIOXIN RESPONSE ELEMENTS<br />
(DRES) UPSTREAM OF BETA-ADRENERGIC<br />
RECEPTOR GENES. J. M. Ciak and R. J. Sommer.<br />
Biology Department, Bates College, Lewiston, ME.<br />
#1832 GLUTATHIONE-S-TRANSFERASE A4-4<br />
MODULATES INOS EXPRESSION THROUGH<br />
NF- κB TRANSLOCATION. Y. Yang 1 , Y. Yang 2 , Y. C.<br />
Awasthi 2 and P. J. Boor 1 . 1 Pathology, UTMB,<br />
Galveston, TX and 2 Human Biological Chemistry and<br />
Genetics, University <strong>of</strong> Texas Medical Branch,<br />
Galveston, TX.<br />
#1833 CHEMICAL INDUCTION OF ANTIOXIDATIVE<br />
AND PHASE 2 DEFENSES IN<br />
CARDIOVASCULAR TISSUES IN VIVO:<br />
INVOLVEMENT OF NRF2 SIGNALING AND<br />
IMPLICATIONS FOR CARDIOVASCULAR<br />
PROTECTION. Y. Li 1 , Z. Cao 1 , H. Zhu 1 , E. Hussey 1 ,<br />
H. Scaramell 1 , K. Itoh 2 , M. Yamamoto 2 , J. M. Cerreta 1<br />
and L. D. Trombetta 1 . 1 St. John’s University, Jamaica,<br />
NY and 2 University <strong>of</strong> Tsukuba, Tsukuba, Japan.<br />
#1834 UPREGULATION OF ENDOGENOUS<br />
ANTIOXIDANTS AND PHASE 2 PROTEINS BY<br />
RESVERATROL IN CULTURED AORTIC<br />
SMOOTH MUSCLE CELLS LEADS TO<br />
CYTOPROTECTION AGAINST OXIDATIVE AND<br />
ELECTROPHILIC STRESS. H. Zhu, Z. Cao and Y.<br />
Li. Pharmaceutical Sciences, St. John’s University,<br />
Jamaica, NY.<br />
#1835 DEXRAZOXAN INHIBITS ALTERATIONS IN<br />
GLYCOLYTIC AND OXIDATIVE CARDIAC<br />
METABOLISM INDUCED BY DOXORUBICIN. R.<br />
A. Carvalho 1 , R. B. Sousa 1 , C. M. Palmeira 1 and K. B.<br />
Wallace 2 . 1 Biochemistry, University <strong>of</strong> Coimbra,<br />
Coimbra, Portugal and 2 Biochemistry & Molecular<br />
Biology, University <strong>of</strong> Minnesota School <strong>of</strong> Medicine,<br />
Duluth, MN.<br />
#1836 METALLOTHIONEIN PROTECTION FROM<br />
PROTEIN NITRATION CAUSED BY LPS/TNF-<br />
ALPHA-DERIVED INTRACELLULAR<br />
PEROXYNITRITE. J. Wang, Y. Kang and L. Cai.<br />
Medicine, University <strong>of</strong> Louisville, Louisville, KY.<br />
#1837 THE ROLE OF ENDOTHELIN-1 AND REACTIVE<br />
OXYGEN SPECIES IN CARDIAC<br />
HYPERTROPHY OBSERVED IN ARYL<br />
HYDROCARBON (AHR) NULL MICE. A. K. Lund 1<br />
and M. K. Walker 1,2 . 1 College <strong>of</strong> Pharmacy, University<br />
<strong>of</strong> New Mexico, Albuquerque, NM and 2 Department <strong>of</strong><br />
Cell Biology and Physiology, University <strong>of</strong> New<br />
Mexico, Albuquerque, NM.<br />
#1838 PCB-INDUCED INFLAMMATORY RESPONSE IN<br />
CAVEOLIN-1 DEFICIENT MICE. Z. Majkova, E.<br />
Smart, A. Daugherty, M. Toborek and B. Hennig.<br />
University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1839 PREVENTION OF DIABETES-ENHANCED LPS<br />
CARDIOTOXICITY IN CARDIAC-SPECIFIC<br />
METALLOTHIONEIN-OVEREXPRESSING<br />
TRANSGENIC MICE. L. Cai and Y. Kang. Medicine,<br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
#1840 GENETIC BACKGROUND-DEPENDANT<br />
VARIATION IN EGFR-RELATED CARDIAC<br />
DYSFUNCTION. D. J. Barrick 1 , M. La Merrill 1 , M.<br />
Rojas 3 , S. Smyth 3 and D. W. Threadgill 2,1 . 1 Curriculum<br />
in <strong>Toxicology</strong>, UNC-CH, Chapel Hill, NC, 2 Genetics,<br />
UNC-CH, Chapel Hill, NC and 3 Carolina<br />
Cardiovascular Biology Center, UNC-CH, Chapel Hill,<br />
NC.<br />
#1841 EFFECTS OF ARSENIC ON ENDOTHELIAL<br />
CELL ACTIVATION AND ACETYLATED-LDL<br />
UPTAKE BY MACROPHAGES. F. E. Pereira, M.<br />
Bunderson, J. C. Schneider, M. C. Schneider, D. D.<br />
C<strong>of</strong>fin and H. D. Beall. Center for Environmental<br />
Health Sciences, University <strong>of</strong> Montana, Missoula, MT.<br />
#1842 EXAMINATION OF THE VASCULAR INJURY IN<br />
SPRAGUE-DAWLEY (SD) RATS INDUCED BY<br />
THE PHOSPHODIESTERASE (PDE) IV<br />
INHIBITOR SCH 534385: A COMPARISION<br />
WITH SCH 351591. J. Zhang 1 , E. H. Herman 1 , A.<br />
Knapton 1 , T. J. Miller 1 , P. Espandiari 1 , R. Snyder 2 , J. P.<br />
Hanig 1 and J. L. Weaver 1 . 1 DAPR, U.S. FDA, Silver<br />
Spring, MD and 2 Schering-Plough Research Institute,<br />
Lafayette, NJ.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 189
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1843 SMOOTH MUSCLE CELL MARKERS OF<br />
FENOLDOPAM INDUCED VASCULAR INJURY.<br />
D. Brott 1,2 , L. Foster-Brown 1 , E. Dubois 1 , H. Jones 3 , R.<br />
J. Richardson 2 and C. Louden 1,2 . 1 Global Safety<br />
Assessment, AstraZeneca Pharmaceuticals, Wilmington,<br />
DE, 2 <strong>Toxicology</strong> <strong>Program</strong>, EHS, The University <strong>of</strong><br />
Michigan, Ann Arbor, MI and 3 Global Safety<br />
Assessment, AstraZeneca Pharmaceuticals, Alderley,<br />
United Kingdom.<br />
#1844 ACROLEIN-INDUCED DYSLIPIDEMIA IN MICE:<br />
A RISK FACTOR OF CARDIOVASCULAR<br />
DISEASE. D. J. Conklin 1 , R. Prough 2 , D. Clark 1 , B.<br />
Hill 1 , S. Srivastava 1 , S. Liu 1 and A. Bhatnagar 1,2 .<br />
1 Cardiology, University <strong>of</strong> Louisville, Louisville, KY<br />
and 2 Biochemistry and Molecular Biology, University<br />
<strong>of</strong> Louisville, Louisville, KY.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: OXIDATIVE STRESS II<br />
Chairperson(s): Susan MacKenzie, DuPont Labs, Newark, DE and Timothy<br />
Phillips, University <strong>of</strong> Texas, College Station, TX.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1845 ATTENUATION OF HYPEROXIA-INDUCED<br />
RETINOPATHIES IN NEONATAL RATS BY<br />
RETINOIC ACID. X. I. Couroucli, L. Kong, Y. Wei,<br />
W. Jiang and B. Moorthy. Pediatrics, Baylor College <strong>of</strong><br />
Medicine, Houston, TX.<br />
#1846 THE SUSCEPTIBILITY OF INBRED MOUSE<br />
STRAINS TO HYPEROXIA-INDUCED LUNG<br />
INJURY. G. S. Whitehead, K. G. Berman, L. H. Burch,<br />
W. Foster and D. A. Schwartz. Medicine, Duke<br />
University, Durham, NC.<br />
#1847 OXIDATION OF PURINE NUCLEOSIDES AND<br />
NUCLEOTIDES WITH DIMETHYLDIOXIRANE:<br />
STRUCTURAL CHARACTERIZATION OF<br />
REACTION PRODUCTS. L. M. Ball, D. E. Degen,<br />
W. Ye, Y. Li, R. Sangaiah and A. Gold. Environmental<br />
Sciences and Engineering, University <strong>of</strong> North Carolina<br />
at Chapel Hill, Chapel Hill, NC.<br />
#1848 PI3-KINASE MEDIATED INDUCTION OF NRF-2<br />
PROTEIN BY OXIDANTS IN<br />
CARDIOMYOCYTES. S. E. Purdom 1 and Q. M.<br />
Chen 2,1 . 1 Interdisciplinary Graduate <strong>Program</strong> in<br />
Genetics and Genomics, University <strong>of</strong> Arizona, Tucson,<br />
AZ and 2 Department <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Arizona, Tucson, AZ.<br />
#1849 HYPERGLYCEMIA-INDUCED OXIDATIVE<br />
STRESS ACTIVATES THE HEXOSAMINE<br />
PATHWAY AND INHIBITS MITOCHONDRIAL<br />
BIOGENESIS. C. M. Palmeira 1 , J. Berthiaume 2 , J. A.<br />
Bjork 2 , A. P. Rolo 1 and K. B. Wallace 2 . 1 Department <strong>of</strong><br />
Zoology, University <strong>of</strong> Coimbra, Center for<br />
Neurosciences and Cell Biology, Coimbra, Portugal and<br />
2 Department <strong>of</strong> Biochemistry & Molecular Biology,<br />
University <strong>of</strong> Minnesota, Medical School, Duluth, MN.<br />
#1850 HYDROQINONE, ρ-BENZOQUINONE, BUT NOT<br />
BENZENE OR PHENOL CAUSE AN INCREASE<br />
IN REACTIVE OXYGEN SPECIES IN HD3<br />
CELLS. J. Wan 1 and L. M. Winn 1,2 . 1 Pharmacology and<br />
<strong>Toxicology</strong>, Queen’s University, Kingston, ON, Canada<br />
and 2 School <strong>of</strong> Environmental Studies, Queen’s<br />
University, Kingston, ON, Canada.<br />
#1851 MEASUREMENT OF OXIDATIVE STRESS<br />
USING KINETIC HIGH CONTENT CELL-BASED<br />
ASSAYS. V. Abraham and J. R. Haskins. Cellomics,<br />
Pittsburgh, PA. Sponsor: E. McGuire.<br />
#1852 ANALYSIS OF THE ROLE OF THE<br />
ANTIOXIDANT RESPONSE ELEMENT IN THE<br />
PROGRESSION OF AMYOTROPHIC LATERAL<br />
SCLEROSIS. C. B. Rideaux, J. C. Kern, D. A. Johnson<br />
and J. A. Johnson. Univeristy <strong>of</strong> Wisconsin-Madison,<br />
Madison, WI.<br />
#1853 ORAL GLUTATHIONE RAPIDLY ELEVATES<br />
GLUTATHIONE LEVELS IN LUNG EPITHELIAL<br />
LINING FLUID AND LAVAGED CELLS. C. T.<br />
kariya 1 , H. Leitner 1 , E. Min 3 and B. J. Day 3,1,2 .<br />
1 Molecular <strong>Toxicology</strong> and Environmental Health<br />
Sciences, UCHSC, Denver, CO, 2 Medicine, UCHSC,<br />
Denver, CO and 3 Medicine, National Jewish Medical<br />
and Research Center, Denver, CO.<br />
#1854 SELECTIVE ENHANCEMENT OF HYPEROXIC<br />
LUNG INJURY BY AUROTHIOGLUCOSE IN<br />
GLUTATHIONE-DEFICIENT MICE SUGGESTS<br />
CROSS-TALK BETWEEN THIOREDOXIN AND<br />
GLUTATHIONE SYSTEMS. S. E. Welty, L. K.<br />
Rogers, T. E. Tipple, T. N. Hansen and C. V. Smith.<br />
Center for Developmental Pharmacolcogy and<br />
<strong>Toxicology</strong>, Columbus Children’s Research Institute,<br />
Columbus, OH.<br />
#1855 PHENOTYPIC ANCHORING OF<br />
ACETAMINOPHEN-INDUCED OXIDATIVE<br />
STRESS AND GENE EXPRESSION PROFILES IN<br />
RAT LIVER. C. L. Powell 1,2 , P. Ross 2 , A. Heinloth 3 ,<br />
G. Boorman 4 , M. Cunningham 4 , R. Paules 3 and I.<br />
Rusyn 1,2 . 1 Curriculum in <strong>Toxicology</strong>, UNC, Chapel<br />
Hill, NC, 2 Department Envr Science & Engr, UNC,<br />
Chapel Hill, NC, 3 NIEHS, National Center for<br />
Toxicogenomics, Research Triangle Park, NC and<br />
4 NIEHS, Envr <strong>Toxicology</strong> <strong>Program</strong>, Research Triangle<br />
Park, NC. Sponsor: I. Rusyn.<br />
#1856 NEAR-INFRARED LIGHT TREATMENT IN A<br />
CELLULAR MODEL OF MITOCHONDRIAL<br />
DYSFUNCTION. K. DeSmet 1 , M. M. Henry 2 , E.<br />
Buchmann 3 , M. Connelly 3 , H. T. Whelan 3,1 and J. T.<br />
Eells 1,3,2 . 1 Health Sciences, University <strong>of</strong> Wisconsin-<br />
Milwaukee, Milwaukee, WI, 2 Ophthalmology, Medical<br />
College <strong>of</strong> Wisconsin, Milwaukee, WI and 3 Neurology,<br />
Medical College <strong>of</strong> Wisconsin, Milwaukee, WI.<br />
#1857 TOLL-LIKE RECEPTOR 4 (TLR4)<br />
CONTRIBUTES TO OZONE-INDUCED<br />
INCREASES IN COSTIMULATORY MOLECULE<br />
(CD86) EXPRESSION IN MICE. G. Backus 1,2 , A. K.<br />
Bauer 2 , H. Cho 2 and S. R. Kleeberger 2 . 1 Curriculum in<br />
<strong>Toxicology</strong>, University <strong>of</strong> North Carolina, Chapel Hill,<br />
NC and 2 NIH/NIEHS, Research Triangle Park, NC.<br />
190<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
#1858 ARSENIC TRIOXIDE INDUCED OXIDATIVE STRESS<br />
IN SPRAGUE-DAWLEY RATS. A. K. patlolla and P. B.<br />
Tchounwou. Biology, Jackson State University, Jackson, MS.<br />
#1859 EFFECT OF ACETAMINOPHEN ON CYTOSOLIC<br />
AND MITOCHONDRIAL GLUTATHIONE IN THE<br />
LIVERS OF WILD-TYPE, GCLM-HETEROZYGOUS,<br />
AND GCLM-NULL MICE. I. Mohar, L. A. McConnachie,<br />
C. Fernandez and T. J. Kavanagh. Department <strong>of</strong><br />
Environmental and Occupational Health Sciences, University<br />
<strong>of</strong> Washington, Seattle, WA.<br />
#1860 ANTIOXIDANT GENE EXPRESSION LEVELS IN<br />
BRAIN AREAS THAT ARE TARGETS OF 1, 3-DNB<br />
MEDIATED NEUROTOXICITY. T. R. Miller 1 and P.<br />
Venkatakrishnan 1 . 1 Graduate Center for <strong>Toxicology</strong>, University<br />
<strong>of</strong> Kentucky, Lexington, KY and 2 Graduate Center for<br />
<strong>Toxicology</strong>, University <strong>of</strong> Kentucky, Lexington, KY.<br />
#1861 ENHANCED RENAL TOXICITY OF FERRIC<br />
NITRILOTRIACETATE IN NRF2 DEFICIENT MICE.<br />
K. KANKI 1 , T. Umemura 1 , Y. Kitamura 1 , Y. Ishii 1 , Y.<br />
Kodama 2 , K. Itoh 3 , M. Yamamoto 3 , A. Nishikawa 1 and M.<br />
Hirose 1 . 1 Division <strong>of</strong> Pathology, National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan, 2 Division <strong>of</strong> <strong>Toxicology</strong>, National<br />
Institute <strong>of</strong> Health Sciences, Tokyo, Japan and 3 Graduate<br />
school <strong>of</strong> Comprehensive Human Sciences, Tsukuba<br />
University, Tsukuba, Japan.<br />
#1862 THE BIO-NANO INTERFACE: EXAMINING THE<br />
INTERACTIONS BETWEEN WATER SOLUBLE<br />
FULLERENES AND BIOLOGICAL MEMBRANES. C.<br />
M. Sayes 1 , J. Mendez 1 , K. D. Ausman 4 , J. L. West 2,4 , J. H.<br />
Hafner 3,4 and V. L. Colvin 1,4 . 1 Chemistry, Rice University,<br />
Houston, TX, 2 Bioengineering, Rice University, Houston, TX,<br />
3 Physics and Astronomy, Rice University, Houston, TX and<br />
4 Center for Biological and Environmental Nanotechnology,<br />
Rice University, Houston, TX.<br />
#1863 INVOLVEMENT OF REACTIVE OXYGEN<br />
FORMATION IN THE 3-HYDROXY-3-<br />
METHYLGLUTARYL-COA REDUCTASE INHIBITOR-<br />
INDUCED SKELETAL MUSCLE CELL DEATH. A.<br />
Wolf 1 , L. Ndountse-Tchapda 1 , U. Schramm 1 and W. E.<br />
Trommer 2 . 1 Biomarker Development, Novartis Pharmacology<br />
AG, Basel, Switzerland and 2 Department <strong>of</strong> Chemistry,<br />
University <strong>of</strong> Kaiserslautern, Kaiserslautern, Germany.<br />
#1864 SURFACE ACTIVITY OF ERIONITE SAMPLES FROM<br />
DIFFERENT LOCALITIES. M. Gulumian 1,2 , M. Semano 1<br />
and G. Hearne 3 . 1 <strong>Toxicology</strong>, NIOH, Johannesburg, Gauteng,<br />
South Africa, 2 Department <strong>of</strong> Haematology and Molecular<br />
Medicine, University <strong>of</strong> the Witwatersrand, Johannesburg,<br />
Gauteng, South Africa and 3 Department <strong>of</strong> Physics,<br />
University <strong>of</strong> the Witwatersrand, Johannesburg, Gauteng,<br />
South Africa. Sponsor: M. Karol.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: IMMUNOTOXICOLOGY IN VITRO/MECHANISMS<br />
Chairperson(s): Norbert Kaminski, Michigan State University, Pharmacology and<br />
<strong>Toxicology</strong>, East Lansing, MI and Brian Freed, University <strong>of</strong> Colorado, Clinical<br />
Immunology Laboratory, Denver, CO.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1865 IDENTIFICATION OF NF-κB MODIFICATIONS<br />
GENERATED BY CIGARETTE SMOKE ALDEHYDES.<br />
C. Lambert, J. Li, M. Portas, S. Lazis, M. Quintana, J.<br />
McCue and B. M. Freed. Allergy and Clinical Immunology,<br />
School <strong>of</strong> Medicine, University <strong>of</strong> Colorado Health Sciences<br />
Center, Denver, CO.<br />
#1866 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN<br />
(TCDD) INDUCES THE EXPRESSION OF FAS AND<br />
FAS LIGAND THROUGH DISTINCT PATHWAYS<br />
INVOLVING DRE AND NF-KAPPAB MOTIFS ON THE<br />
PROMOTERS. N. P. Singh 1 . 1 Pharmacology & <strong>Toxicology</strong>,<br />
Virginia Commonwealth University, Richmond, VA and<br />
2 Microbiology & Immunology, Medical College <strong>of</strong> Virginia<br />
Campus, Virginia Commonwealth University, Richmond, VA.<br />
Sponsor: P. Nagarkatti.<br />
#1867 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN<br />
(TCDD) DISRUPTS THE NORMAL DAILY RHYTHMS<br />
OF HEMATOPOIETIC PRECURSORS. R. Garrett and T.<br />
A. Gasiewicz. Environmental Medicine, University <strong>of</strong><br />
Rochester School <strong>of</strong> Medicine & Dentistry, Rochester, NY.<br />
#1868 INTERFERON-GAMMA REVERSES TCDD-<br />
MEDIATED SUPPRESSION OF THE IGM ANTIBODY<br />
RESPONSE AND ATTENUATES CYP1A1 INDUCTION.<br />
N. Kaminski 2,3 , B. Kim 1 , R. Crawford 2 and M. Holsapple 2 .<br />
1 Biological Sciences and Immunomodulation Research<br />
Center, University <strong>of</strong> Ulsan, Ulsan, South Korea,<br />
2 Pharmacology and <strong>Toxicology</strong>, Michigan State University,<br />
East Lansing, MI and 3 Center for Integrative <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI.<br />
#1869 MAP KINASES, BUT NOT CALCIUM OR REACTIVE<br />
OXYGEN SPECIES, ARE INVOLVED IN PPARγ<br />
AGONIST-INDUCED PRO/PRE-B CELL APOPTOSIS.<br />
D. Liu, J. Emberley, D. Sherr and J. Schlezinger.<br />
Environmental Health, Boston University School <strong>of</strong> Public<br />
Health, Boston, MA.<br />
#1870 CASPASE-8 IS NOT THE MOST PROXIMAL CASPASE<br />
INVOLVED IN DMBA-INDUCED BONE MARROW B<br />
CELL APOPTOSIS. D. H. Sherr, H. Ryu, J. K. Emberley, L.<br />
L. Allan and J. J. Schlezinger. Environmental Health, Boston<br />
University, Boston, MA.<br />
#1871 THE ROLE OF PAH METABOLISM IN AHR-<br />
DEPENDENT INHIBITION OF HUMAN B CELL<br />
PROLIFERATION. L. L. Allan 1,2 , J. J. Schlezinger 2 , M.<br />
Shansab 2 and D. H. Sherr 2 . 1 Microbiology, Boston University<br />
School <strong>of</strong> Medicine, Boston, MA and 2 Environmental Health,<br />
Boston University School <strong>of</strong> Medicine, Boston, MA.<br />
#1872 DISTINCT EFFECTS OF TGF-B1 ON THE SURVIVAL<br />
AND DIVISION OF CD4+ AND CD8+ T CELLS: A<br />
ROLE FOR T CELL INTRINSIC SMAD3. S. C. McKarns<br />
and R. H. Schwartz. Laboratory <strong>of</strong> Cellular and Molecular<br />
Immunology, National Institute <strong>of</strong> Allergy and Infectious<br />
Diseases, NIH, Bethesda, MD.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 191
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1873 EXPOSURE TO TCDD AUGMENTS CD25<br />
EXPRESSION ON RECENTLY ACTIVATED T<br />
CELLS. C. J. Funatake, L. B. Steppan and N. I.<br />
Kerkvliet. Environmental and Molecular <strong>Toxicology</strong>,<br />
Oregon State University, Corvallis, OR.<br />
#1874 ∆ 9 -TETRAHYDROCANNABINOL (∆ 9 -THC)<br />
ELICITS A CALCIUM ELEVATION IN T CELLS<br />
THROUGH THE TRPC CHANNELS. G. Rao 1,2 and<br />
N. E. Kaminski 1,2 . 1 Pharmacology and <strong>Toxicology</strong>,<br />
Michigan State University, East Lansing, MI and<br />
2 Center for Integrative <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI.<br />
#1875 SODIUM ARSENITE DECREASES<br />
PROLIFERATION IN PHA-STIMULATED<br />
LYMPHOCYTES, BY INHIBITING<br />
INTERLEUKIN-2 EXPRESSION AND<br />
SECRETION. P. C. Conde-Moo, L. C. Acosta-<br />
Saavedra, M. E. Cebrian and E. S. Calderon-Aranda.<br />
Toxicologia, Cinvestav, Mexico, DF, Mexico.<br />
#1876 MECHANISMS OF 4-HYDROXYNONENAL-HNE<br />
(LIPID HYDROPEROXIDE) INDUCED<br />
APOPTOTIC DEATH IN CD4 T LYMPHOCYTES:<br />
RELEVANCE TO HIV AND HCV<br />
PATHOGENESIS. W. Chang 1 , R. Sahoo 2 , S.<br />
Srivastava 2 , C. J. McClain 2,1 , T. S. Chen 1 and S. S.<br />
Barve 2,1 . 1 Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong><br />
Louisville, Louisville, KY and 2 Medicine, University <strong>of</strong><br />
Louisville, Louisville, KY.<br />
#1877 MECHANISMS OF LEAD-INDUCED<br />
IMMUNOTOXICITY: THE ROLE OF IL-2 IN<br />
ALLO-ENHANCEMENT. S. M. Hueber, D. G. Farrer<br />
and M. J. McCabe. Environmental Medicine, School <strong>of</strong><br />
Medicine and Dentistry, University <strong>of</strong> Rochester,<br />
Rochester, NY.<br />
#1878 ENFUVIRTIDE: IN VITRO STUDIES OF<br />
PUTATIVE IMMUNOTOXIC EFFECTS<br />
RELATED TO ACTIVATION OF N-FORMYL<br />
PEPTIDE RECEPTORS. F. Regenass 1 , M.<br />
Adibzadeh 1 , T. D. Steele 2 and H. Kropsh<strong>of</strong>er 1 .<br />
1 Nonclinical Drug Safety, H<strong>of</strong>fmann-LaRoche, Inc.,<br />
Basel, Switzerland and 2 Nonclinical Drug Safety,<br />
H<strong>of</strong>fmann-LaRoche, Inc., Nutley, NJ. Sponsor: A.<br />
Braen.<br />
#1879 INFLAMMATORY RESPONSES IN MOUSE<br />
RAW264.7 MACROPHAGES CAN BE ALTERED<br />
BY INTERACTIONS BETWEEN INDOOR AIR<br />
MICROBES IN SIMULTANEOUS EXPOSURE. P.<br />
Penttinen 1,2 , K. Huttunen 1 , J. Pelkonen 2,3 and M.<br />
Hirvonen 1 . 1 Department <strong>of</strong> Environmental Health,<br />
National Public Health institute, Kuopio, Finland,<br />
2 3 University <strong>of</strong> Kuopio, Kuopio, Finland and Kuopio<br />
University Hospital, Kuopio, Finland. Sponsor: M.<br />
Viluksela.<br />
#1880 SIMULTANEOUS EXPOSURE TO MOLDY<br />
HOUSE MICROBES STREPTOMYCES<br />
CALIFORNICUS AND STACHYBOTRYS<br />
CHARTARUM CAUSE SYNERGISTIC<br />
INFLAMMATORY RESPONSES IN HUMAN<br />
WHOLE BLOOD CELL CULTURE. M. Roponen,<br />
K. Huttunen, M. Lappalainen and M. Hirvonen.<br />
Department <strong>of</strong> Environmental Health, National Public<br />
Health Institute, Kuopio, Finland. Sponsor: M.<br />
Viluksela.<br />
#1881 THE BIOLOGICAL ACTIVITY OF GRAM-<br />
POSITIVE BACTERIA STREPTOMYCES<br />
CALIFORNICUS CANNOT BE COMPLETELY<br />
INHIBITED WITH LPS -INHIBITOR PMX. K.<br />
Huttunen, A. Halinen and M. Hirvonen. Department <strong>of</strong><br />
Environmental Health, National Public Health Institute,<br />
Kuopio, Finland. Sponsor: M. Viluksela.<br />
#1882 IN VITRO AND IN VIVO IMMUNOLOGIC<br />
RESPONSES BY POLYACRYLAMIDE<br />
NANOPARTICLES TO MH-S CELLS AND RATS.<br />
R. J. Schneider 1 , R. Reddy 2 and M. A. Philbert 1 .<br />
1 Environmental Health Sciences, University <strong>of</strong><br />
Michigan, Ann Arbor, MI and 2 Molecular Therapeutics,<br />
Inc., Ann Arbor, MI.<br />
#1883 IMPACT OF EXPOSURE TO JET A JET FUEL ON<br />
CYTOKINE PRODUCTION IN RAT LUNG<br />
MACROPHAGES. D. L. Courson 1 , E. R. Wilfong 1 , J.<br />
R. Cunningham 2 , E. W. Johnson 1 and S. Lohrke 1 .<br />
1 Naval Health Research Center / Detachment EHE<br />
Laboratory, Wright-Patterson AFB, Fairborn, OH and<br />
2 Wright State University, Fairborn, OH.<br />
#1884 MACROPHAGES ARE THE PROXIMAL<br />
TARGET CELL IN LEAD-INDUCED<br />
IMMUNOTOXICITY. D. G. Farrer and M. J.<br />
McCabe. Environmental Medicine, School <strong>of</strong> Medicine<br />
and Dentistry, University <strong>of</strong> Rochester, Rochester, NY.<br />
#1885 WOOD DUST-INDUCED PULMONARY<br />
INFLAMMATION IN MICE. J. Maatta, M. Lehto, M.<br />
Leino, S. Tillander, H. Haataja, K. Savolainen and H.<br />
Alenius. Department <strong>of</strong> Industrial Hygiene and<br />
<strong>Toxicology</strong>, Finnish Institute <strong>of</strong> Occupational Health,<br />
Helsinki, Finland.<br />
#1886 ATRAZINE-INDUCED INHIBITION OF NK-CELL<br />
MEDIATED CYTOTOXICITY. A. M. Rowe 1 , K. M.<br />
Brundage 1,2 , R. Schafer 2 and J. B. Barnett 1,2 .<br />
1 Microbioloy, Immunology and Cell Biology, West<br />
Virginia University, Morgantown, WV and 2 Mary Babb<br />
Randolph Cancer Center, Morgantown, WV.<br />
#1887 ALTERATIONS IN CYTOKINE PRODUCTION IN<br />
THE PRESENCE OF THE PESTICIDES,<br />
BENTAZON, ISOXAFLUTOLE AND TERBUFUS.<br />
K. M. Brundage 1 and R. S. Ellis 2 . 1 Microbiology,<br />
Immunology and Cell Biology, West Virginia<br />
University, Morgantown, WV and 2 BlueField State<br />
College, Bluefield, WV.<br />
192<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1888 THE FUNGICIDES<br />
ETHYLENEBISDITHIOCARBAMATES INHIBIT<br />
NF-KB ACTIVATION AND CYTOKINE<br />
PRODUCTION IN THE HUMAN<br />
PROMYELOCYTIC CELL LINE THP-1. E.<br />
Corsini 1 , S. Birindelli 2 , M. Marinovich 1 , C. L. Galli 1<br />
and C. Colosio 2 . 1 Pharmacological Sciences, University<br />
<strong>of</strong> Milan, Milan, Italy and 2 ICPS, International Centre<br />
for Pesticides and Health Risk Prevention, Busto<br />
Garolfo, Italy.<br />
#1889 ANALYSIS OF THE PROTEOMIC CHANGES<br />
INDUCED BY PROPANIL ON A MACROPHAGE<br />
CELL LINE. I. V. Ustyugova 1 , C. L. Walton 1 , K. M.<br />
Brundage 1,2 and J. B. Barnett 1,2 . 1 Proteomic Core<br />
Facility, Department <strong>of</strong> Microbiology, Immunology and<br />
Cell Biology, West Virginia University, Morgantown,<br />
WV and 2 Mary Babb Randolph Cancer Center, West<br />
Virginia University, Morgantown, WV.<br />
#1890 ALTERED ACTIVATION OF T CELLS BY<br />
SILICA-EXPOSED ANTIGEN-PRESENTING<br />
CELLS. C. T. Migliaccio and A. Holian. Ctr for<br />
Environ Health Sciences/Biomed Pharmacology<br />
Sciences, University <strong>of</strong> Montana, Missoula, MT.<br />
#1891 ROLE OF NEUTROPHILS IN 1-<br />
NITRONAPHTHALENE-INDUCED<br />
PULMONARY INJURY AND REPAIR. L. Pantle, M.<br />
Fanucchi and C. Plopper. University <strong>of</strong> California,<br />
Davis, Davis, CA.<br />
#1892 PARTICULATE MATTER-INDUCED AIRWAY<br />
INFLAMMATION CORRELATES WITH<br />
IMMUNE ADJUVANT POTENTIAL. C. de Haar, I.<br />
Hassing, R. Bleumink and R. Pieters. Institute for Risk<br />
Assessment Sciences, Utrecht, Netherlands.<br />
#1893 IMMUNE RESPONSE OF HUMAN<br />
LYMPHOBLASTOID AND BRONCHIAL<br />
EPITHELIAL CELL LINES TO ORGANIC<br />
COMPOUNDS FROM FINE PARTICLES (PM2.5)<br />
IN PUERTO RICO. E. Fuentes-Mattei 1,3 , I.<br />
Rodriguez-Fernandez 2,3 , A. Gioda 3 , W. Delgado-<br />
Morales 1 and B. D. Jimenez Velez 1,3 . 1 Biochemistry,<br />
UPR Medical Sciences Campus, San Juan, Puerto Rico,<br />
2 Biology, UPR Ponce Campus, Ponce, Puerto Rico and<br />
3 Center <strong>of</strong> Environmental and Toxicological Research-<br />
UPR Medical Science Campus, San Juan, Puerto Rico.<br />
#1894 MURINE PULMONARY MACROPHAGE<br />
EXPRESSION AND PRODUCTION OF TNFA AND<br />
MIP-2 AFTER EXPOSURE TO DIESEL EXHAUST<br />
PARTICLES (DEP) AND EXTRACTS. T. Stevens 1 ,<br />
M. Daniels 2 and I. Gilmour 2 . 1 UNC, Chapel Hill, NC<br />
and 2 EPA, Research Triangle Park, NC.<br />
#1895 IN-VITRO INFLAMMATORY AND CYTOTOXIC<br />
RESPONSES TO URBAN AIR FINE AND<br />
ULTRAFINE PARTICULATE SAMPLES<br />
COLLECTED DURING CONTRASTING<br />
POLLUTION SITUATIONS IN SIX EUROPEAN<br />
CITIES (PAMCHAR). P. Jalava 1,2 , R. O. Salonen 1 , A.<br />
I. Halinen 1 and M. Hirvonen 1 . 1 Department <strong>of</strong><br />
Environmental Health, National Public Health Institute<br />
(KTL), Kuopio, Finland and 2 University <strong>of</strong> Kuopio,<br />
Kuopio, Finland. Sponsor: M. Viluksela.<br />
#1896 EXPRESSION AND KINETICS OF TOLL-LIKE<br />
RECEPTORS AND INFLAMMATORY<br />
CYTOKINE SECRETION IN MURINE<br />
ALVEOLAR MACROPHAGES. K. M. Gowdy 2,1 , M.<br />
Daniels 1 , E. Boykin 1 and M. Gilmour 1 . 1 Environmental<br />
<strong>Toxicology</strong> Division, U.S. EPA, Research Triangle Park,<br />
NC and 2 North Carolina State University, Raleigh, NC.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: LIVER II<br />
Chairperson(s): Martin Ronis, University <strong>of</strong> Arkansas Medical Sciences,<br />
Little Rock, AR.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#1897 IMPROVED RAT MODELS FOR PREDICTIVE<br />
TOXICOLOGY. S. Nye, N. Cozzi, J. Baye, A.<br />
Wittenburg, S. Korb, Y. Evrard, R. Roman and H.<br />
Jacob. Research & Development, PhysioGenix, Inc.,<br />
Wauwatosa, WI. Sponsor: Y. Dragan.<br />
#1898 IN VIVO HEPATIC CELL PROLIFERATION IS<br />
AN EARLY, SENSITIVE MARKER OF<br />
HEPATOTOXICITY. S. Turner 1 , J. Gardner 1 , J.<br />
Stark 1 , D. Buffmum 2 and M. Hellerstein 3,2,1 . 1 Research,<br />
Kinemed Inc., Emeryville, CA, 2 Medicine, UC San<br />
Francisco, San Francisco, CA and 3 Nutritional Sciences<br />
and <strong>Toxicology</strong>, UC Berkeley, Berkeley, CA. Sponsor:<br />
I. Heyman.<br />
#1899 INVESTIGATIONS OF THE EFFECTS ON<br />
PROTEIN EXPRESSION INDUCED BY<br />
HEPATOTOXICANTS ON PRIMARY CULTURED<br />
RAT HEPATOCYTES. T. Yamamoto, T. Fukushima,<br />
R. Kikkawa, H. Yamada and I. Horii. Worldwide Safety<br />
Sciences, Pfizer Japan Inc., Taketoyo, Aichi, Japan.<br />
Sponsor: M. Kurata.<br />
#1900 PROTEOMIC ANALYSIS OF LIVER AND SERUM<br />
FROM LIPOSACCHARIDE TREATED RATS<br />
DURING ACUTE INFLAMMATION. J. H.<br />
Madenspacher 1 , M. E. Bruno 1 , B. A. Wetmore 1 , R.<br />
Pieper 2 , C. L. Gatlin 2 , A. J. Makusky 2 , A. M. McGrath 2 ,<br />
M. Zhao 2 , J. Zhou 2 , J. Taylor 2 , S. Steiner 2 , R. W.<br />
Tennant 1 , K. B. Tomer 1 and B. A. Merrick 1 . 1 National<br />
Center for Toxicogenomics, NIEHS, Research Triangle<br />
Pk, NC and 2 Proteomics Division, Large Scale Biology<br />
Corporation, Research Triangle Pk, NC.<br />
#1901 EVALUATION OF THE BACKGROUND DATA<br />
OBTAINED IN THE TOXICOGENOMICS<br />
PROJECT IN JAPAN. H. Nitta, T. Miyazaki, H.<br />
Totsuka, T. Miyagishima, T. Urushidani and T. Nagao.<br />
Toxicogenomics Project, National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan. Sponsor: T. Inoue.<br />
#1902 THIOACETAMIDE AND METHAPYRILENE<br />
SHOWED A UNIQUE GENE EXPRESSION<br />
PROFILE AMONG THE CHEMICALS IN THE<br />
TOXICOGENOMICS PROJECT IN JAPAN. Y.<br />
Mizukawa, T. Miyagishima, T. Urushidani and T.<br />
Nagao. Toxicogenomics Project, National Institute <strong>of</strong><br />
Health Sciences, Tokyo, Japan. Sponsor: T. Inoue.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 193
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1903 GENE EXPRESSION IN PORPHYRIA INDUCED<br />
BY 2, 3, 7, 8-TETRACHLORO-DIBENZO-P-<br />
DIOXIN IN SUSCEPTIBLE MICE. A. G. Smith, B.<br />
Clothier and R. Davies. MRC <strong>Toxicology</strong> Unit,<br />
University <strong>of</strong> Leicester, Leicester, United Kingdom.<br />
#1904 STRESS- AND INFLAMMATORY-RELATED<br />
MNRA INDUCTION IN HEPATOCYTES AND<br />
NON-PARENCHYMAL CELLS RESPONSE TO<br />
OXIDATIVE STIMULI. T. Yamamoto, H. Utsumi, N.<br />
Shimada and N. Tsutsui. Mitsubishi Pharmacology<br />
Corporation, Kisarazu, Chiba, Japan. Sponsor: J.<br />
Sugimoto.<br />
#1905 DEVELOPMENT OF PROTEIN MICROARRAY<br />
TECHNOLOGY TO FACILITATE<br />
IDENTIFICATION OF PROTEINS ISOLATED BY<br />
GEL FILTRATION AND ION-EXCHANGE<br />
CHROMATOGRAPHIES. H. Kim 1,2 , Y. Yuan 1 , D. J.<br />
Kaplan 1 , D. A. Putt 1 , Z. Li 1 and K. Fleischmann 1 .<br />
1 2 Detroit R&D, Inc., Detroit, MI and Institute <strong>of</strong><br />
Environmental Health Sciences, Wayne State<br />
University, Detroit, MI.<br />
#1906 HEPATIC GENE EXPRESSION PROFILES OF<br />
RATS EXPOSED TO<br />
PERFLUOROOCTANESULFONATE (PFOS) IN<br />
UTERO. J. A. Bjork 1 , J. M. Berthiaume 1 , C. Lau 2 , J. L.<br />
Butenh<strong>of</strong>f 3 and K. B. Wallace 1 . 1 Biochem. & Mol.<br />
Biology, Medical School, University <strong>of</strong> Minnesota,<br />
Duluth, MN, 2 Reproductive <strong>Toxicology</strong> Division,<br />
NHEERL, U.S. EPA, Research Triangle Park, NC and<br />
3 3M Company, St. Paul, MN.<br />
#1907 LIVER SLICE MODEL SYSTEM FOR BILIARY<br />
CELL EFFECTS: CHANGES IN CLINICAL<br />
CHEMISTRY PARAMETERS. H. P. Behrsing, C. Ip,<br />
L. Jimenez and C. A. Tyson. <strong>Toxicology</strong> Laboratory, SRI<br />
International, Menlo Park, CA.<br />
#1908 LIVER SLICE MODEL SYSTEM FOR BILIARY<br />
CELL EFFECTS: HISTOLOGICAL CHANGES. K.<br />
Amin, C. Ip, H. P. Behrsing and C. A. Tyson.<br />
<strong>Toxicology</strong> Laboratory, SRI International, Menlo Park,<br />
CA.<br />
#1909 IMPAIRED G1 TO S-PHASE SIGNALING<br />
EXPLAINS INHIBITED TISSUE REPAIR IN<br />
THIOACETAMIDE-TREATED TYPE 1 DIABETIC<br />
RATS. S. S. Devi and H. M. Mehendale. <strong>Toxicology</strong>,<br />
The University <strong>of</strong> Louisiana at Monroe, Monroe, LA.<br />
#1910 MOLECULAR MECHANISMS OF INHIBITED<br />
COMPENSATORY LIVER REPAIR UPON<br />
HEPATOTOXIC CHALLENGE IN TYPE 2<br />
DIABETIC RATS. S. P. Sawant 1 , A. V. Dnyanmote 1 , J.<br />
R. Latendresse 2 , A. Warbritton 2 and H. M. Mehendale 1 .<br />
1 The University <strong>of</strong> Louisiana at Monroe, Monroe, LA<br />
and 2 NCTR, Jefferson, AR.<br />
#1911 PPARβ-MEDIATED HEPATOTOXICITY IN A<br />
DIETARY MODEL OF NONALCOHOLIC<br />
STEATOHEPATITIS (NASH). M. A. Peraza, W.<br />
Shan, M. J. Kennett and J. M. Peters. Veterinary<br />
Sciences, Center for Molecular <strong>Toxicology</strong> and<br />
Carcinogenesis, The Pennsylvania State University,<br />
University Park, PA.<br />
#1912 INDUCTION OF CYTOTOXICITY IN PRIMARY<br />
RAT HEPATOCYTES AND HUMAN HEPG2<br />
CELLS BY SELECTED PPARγ AGONISTS. L.<br />
Guo 1 , L. Muskhelishvili 2 , E. Blann 1 , S. Dial 1 , E.<br />
Hermann 3 and Y. Dragan 1 . 1 Systems <strong>Toxicology</strong>,<br />
National Center for Toxicolological Research, Jefferson,<br />
AR, 2 Molecular Pathology Branch, Charles River<br />
Laboratories at NCTR, Jefferson, AR and 3 Center for<br />
Drug Evaluation and Research, Jefferson, AR.<br />
#1913 INDUCTION OF EARLY FIBROGENESIS IN<br />
PRECISION-CUT HUMAN AND RAT LIVER<br />
SLICES AFTER CARBON TETRACHLORIDE<br />
TOXICITY. M. van de Bovenkamp 1 , G. M.<br />
Groothuis 1 , A. L. Draaisma 1 , M. T. Merema 1 , D. K.<br />
Meijer 1 , S. L. Friedman 2 and P. Olinga 1 .<br />
1 Pharmacokinetics and Drug Delivery, University <strong>of</strong><br />
Groningen, Groningen, Netherlands and 2 Division <strong>of</strong><br />
Liver Diseases, Mount Sinai School <strong>of</strong> Medicine, New<br />
York. Sponsor: A. Vickers.<br />
#1914 HUMAN LIVER AND KIDNEY SLICE VIABILITY<br />
IS EXTENDED AND PATHWAYS OF FIBROSIS<br />
ARE CHARACTERIZED. A. E. Vickers 1 , R. L.<br />
Fisher 2 and P. Olinga 3 . 1 Safety Evaluation, Allergan,<br />
Inc., Irvine, CA, 2 Vitron Inc., Tucson, AZ and<br />
3 Department Pharmacokinetics & Drug Delivery,<br />
University Groningen, Groningen, Netherlands.<br />
#1915 THE EFFECT OF THE PPARα AGONIST WY-14,<br />
643 ON MITOCHONDRIAL MEMBRANE<br />
POTENTIAL IN HUMAN AND RODENT LIVER<br />
CELL LINES. S. Barnes 1 , S. E. Boldt 2 , A. K.<br />
Hubbard 1 , J. Singh 2 and D. E. Amacher 2 . 1 Department<br />
<strong>of</strong> Pharmaceutical Sciences, University <strong>of</strong> Connecticut,<br />
Storrs, CT and 2 Drug Safety Evaluation, Pfizer Inc.,<br />
Groton, CT.<br />
#1916 IN SITU QUANTITATIVE EVALUATION OF<br />
PEROXISOMAL PROLIFERATION IN THE NON-<br />
HUMAN PRIMATE LIVER VIA LASER<br />
SCANNING CYTOMETRY (LSC). L. A. Obert 1 , V.<br />
Kostrubsky 1 , C. Okerberg 1 , J. Wijsman 1 , E. Urda 1 , J.<br />
Hanson 1 , K. Toy 1 , W. Collard 1 , W. Maier 1 , R. Bell 1 , L.<br />
Zwick 2 , S. Frantz 2 , R. Dunstan 1 and R. Adler 1 .<br />
1 2 WWSS, Pfizer Inc., Ann Arbor, MI and MPI<br />
Research, Mattawan, MI.<br />
#1917 COMPARISON OF ALDEHYDE<br />
DEHYDROGENASE (ALDH) ACTIVITY IN THE<br />
LIVER AND LUNG. M. Yoon 1,2 , M. C. Madden 2 and<br />
H. A. Barton 2 . 1 NRC, The National Academies,<br />
Washington, DC and 2 NHEERL, U.S. EPA, Research<br />
Triangle Park, NC.<br />
#1918 ETHANOL HAS BIPHASIC EFFECTS ON<br />
EXPRESSION OF STEROL REGULATORY<br />
ELEMENT BINDING PROTEIN-1 (SREBP-1) IN<br />
RAT FGC-4 HEPATOMA CELLS WITH<br />
INHIBITION AT HIGH DOSES RESULTING IN<br />
INDUCTION OF ADH CLASS I. L. He 1,3 , M. J.<br />
Ronis 2,3 , F. A. Simmen 1,3 and T. M. Badger 1,3 .<br />
1 Physiology & Biophysics, University <strong>of</strong> Arkansas for<br />
Medical Sciences, Little Rock, AR, 2 Pharmacology &<br />
<strong>Toxicology</strong>, University <strong>of</strong> Arkansas for Medical<br />
Sciences, Little Rock, AR and 3 Arkansas Children’s<br />
Nutrition Center, Little Rock, AR.<br />
194<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1919 ETHANOL INDUCES RAT HEPATIC ALCOHOL<br />
DEHYDROGENASE (ADH) CLASS I BY<br />
INTERFERING WITH POST-TRANSLATIONAL<br />
REGULATION OF STEROL REGULATORY<br />
ELEMENT BINDING PROTEIN-1 (SREBP-1). T.<br />
M. Badger 1,3 , L. He 1,3 , F. A. Simmen 1,3 and M. J.<br />
Ronis 2,3 . 1 Physiology & Biophysics, University <strong>of</strong><br />
Arkansas for Medical Sciences, Little Rock, AR,<br />
2 Pharmacology & <strong>Toxicology</strong>, University <strong>of</strong> Arkansas<br />
for Medical Sciences, Little Rock, AR and 3 Arkansas<br />
Children’s Nutrition Center, Little Rock, AR.<br />
#1920 MICE WITH HEPATOCYTE-SPECIFIC RXRα<br />
DEFICIENCY HAVE ALTERED ALCOHOL<br />
METABOLISM. M. G. Kocsis, A. J. Mendy, G. Dai<br />
and Y. Y. Wan. Pharmacology, <strong>Toxicology</strong> &<br />
Therapeutics, University <strong>of</strong> Kansas Medical Center,<br />
Kansas City, KS.<br />
#1921 TEMPORAL AND ZONAL EXPRESSION<br />
PATTERNS OF LIVER MRP4 AND NTCP<br />
FOLLOWING HEPATOTOXICANT EXPOSURE.<br />
L. Aleksunes 1 , G. Scheffer 2 and J. Manautou 1 .<br />
1 Pharmaceutical Sciences, University <strong>of</strong> Connecticut,<br />
Storrs, CT and 2 Pathology, University Hospital Free<br />
University, Amsterdam, Netherlands.<br />
#1922 METHYLENEDIANILINE INJURY TO LIVERS<br />
OF TR - [LIVER CANALICULAR MRP2<br />
TRANSPORTER-DEFICIENT] RATS IS NOT<br />
LINKED TO OXIDATIVE STRESS. M. F. Kanz, B.<br />
Ramasubramanian, Y. Chen, F. Nayeem and M. Treinen-<br />
Moslen. Pathology, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX.<br />
#1923 PLASMA ESTERASE ACTIVITY PROTECTS<br />
AGAINST COCAINE HEPATOTOXICITY IN<br />
FEMALE MICE. M. S. Abdel-Rahman 1 , R. M.<br />
Turkall 1,2 and T. Visalli 1 . 1 Pharmacology/Physiology,<br />
UMDNJ, Newark, NJ and 2 Clinical Laboratory<br />
Sciences, School <strong>of</strong> Health Related Pr<strong>of</strong>essions<br />
UMDNJ, Newark, NJ.<br />
#1924 IDENTIFICATION OF NOVEL SUBSTRATES<br />
AND INHIBITORS OF SOLUBLE EPOXIDE<br />
HYDROLASE N-TERMINAL PHOSPHATASE<br />
ACTIVITY BASED ON ITS SUBCELLULAR<br />
LOCALIZATION. A. Enayetallah 1 , P. Srivastava 1 , M.<br />
Barber 2 , P. Mungalachetty 1 , B. Luo 1 and D. Grant 1 .<br />
1 Pharmaceutical sciences, University <strong>of</strong> Connecticut,<br />
Storrs, CT and 2 Biotechnology/Bioservices Center,<br />
University <strong>of</strong> Connecticut, Storrs, CT.<br />
#1925 EFFECTS OF BETAINE SUPPLEMENTATION<br />
ON HEPATIC METABOLISM OF SULFUR-<br />
CONTAINING AMINO ACIDS IN MICE. Y. C.<br />
Kim 1 and S. K. Kim 2 . 1 College <strong>of</strong> Pharmacy, Seoul<br />
National University, Seoul, South Korea and 2 College<br />
<strong>of</strong> Pharmacy, Chungnam National University, Daijeon,<br />
South Korea. Sponsor: G. Carlson.<br />
#1926 APPLICATION OF QSARS TO EVALUATE<br />
MOLECULAR MECHANISMS OF<br />
HALOBENZENE INDUCED CYTOTOXICITY IN<br />
RAT HEPATOCYTES. K. Chan and P. J. O’Brien.<br />
Pharmaceutical Sciences, University <strong>of</strong> Toronto,<br />
Toronto, ON, Canada. Sponsor: G. Cherian.<br />
#1927 ACTIVATION OF PROMUTAGENS WITH<br />
HUMAN LIVER S9 AND HUMAN<br />
HEPATOCYTES USING CHINESE HAMSTER<br />
OVARY MICRONUCLEUS ASSAY. S. K. Roy 1 , A. P.<br />
Li 2,3 , B. Chris 4 , K. Paul 1 and A. Thilagar 1,2 . 1 SITEK<br />
Research Laboratories, Rockville, MD, 2 The ADMET<br />
Group, LLC, Rockville, MD, 3 In Vitro ADMET<br />
Laboratories, LLC, Rockville, MD and 4 Tissue<br />
Transformation Technologies Inc., Edison, NJ.<br />
#1928 RUBRATOXIN B INDUCED TISSUE INHIBITOR<br />
OF METALLOPROTEINASES (TIMP)-1<br />
SECRETION IN HEPG2 CELLS. H. Nagashima 1 , K.<br />
Maeda-Nakamura 1 , K. Iwashita 1 and T. Goto 2 .<br />
1 National Food Research Institute, Tsukuba, Ibaraki,<br />
Japan and 2 Faculty <strong>of</strong> Agriculture, Shinshu University,<br />
Minamiminowa, Nagano, Japan. Sponsor: M.<br />
Fukayama.<br />
#1929 FUMONISIN B 1 AND TNFα INDUCED<br />
INCREASES IN SPHINGANINE AND<br />
SPHINGOSINE IN HEPG2 HEPATOCYTES ARE<br />
ATTENUATED BY SP600125, A JNK INHIBITOR.<br />
S. Hsiao 1 , P. D. Constable 2 , M. E. Tumbleson 3 and W.<br />
M. Haschek 1 . 1 Veterinary Pathobiology, University <strong>of</strong><br />
Illinois at Urbana-Champaign, Urbana, IL, 2 Veterinary<br />
Clinical Medicine, University <strong>of</strong> Illinois at Urbanachampaign,<br />
Urbana, IL and 3 Agricultural and Biological<br />
Engineering, University <strong>of</strong> Illinois at Urbana-<br />
Champaign, Urbana, IL.<br />
#1930 AUGMENTATION OF LIPOPOLYSACCHARIDE-<br />
INDUCED GENE EXPRESSION AND LIVER<br />
INJURY BY RANITIDINE BUT NOT<br />
FAMOTIDINE. J. P. Luyendyk 1 , L. D. Lehman-<br />
McKeeman 2 , D. M. Nelson 2 , V. Bhaskaran 2 , B. D. Car 2 ,<br />
G. H. Cantor 2 , C. M. North 1 , S. W. Newport 1 , J. F.<br />
Maddox 1 , P. E. Ganey 1 and R. A. Roth 1 . 1 Department <strong>of</strong><br />
Pharmacology and <strong>Toxicology</strong>, Michigan State<br />
University, East Lansing, MI and 2 Discovery<br />
<strong>Toxicology</strong>, Bristol-Myers Squibb, Princeton, NJ.<br />
#1931 1H-NMR BASED METABONOMICS STUDY OF<br />
GALACTOSAMINE, METHYLENE DIANILINE,<br />
AND CLOFIBRATE IN RATS. N. Katsutani and T.<br />
Aoki. Eisai Co., Ltd.,, Drug Safety Research<br />
Laboratories, Hashima, Gifu-ken, Japan.<br />
#1932 EVALUATION OF A NOVEL ANTI-TUMOR<br />
DRUG USING IN VITRO TOXICITY SCREENING<br />
IN RAT HEPATOMA (H4IIE) CELLS, NORMAL<br />
RAT KIDNEY (NRK) CELLS, AND RAT<br />
PRIMARY HEPATOCYTES. P. C. Wilga, J. M.<br />
McKim, Jr., J. F. Pregenzer and D. K. Petrella. CeeTox,<br />
Kalamazoo, MI.<br />
#1933 UPREGULATION OF STEM CELL-DERIVED<br />
TYROSINE KINASE (STK) EXPRESSION IN<br />
LIVER MACROPHAGES AND ENDOTHELIAL<br />
CELLS DURING ACUTE ENDOTOXEMIA IS<br />
INDEPENDENT OF TUMOR NECROSIS FACTOR<br />
RECEPTOR-1. L. C. Chen, J. Laskin and D. Laskin.<br />
Joint Graduate <strong>Program</strong> in <strong>Toxicology</strong>, Rutgers<br />
University and UMDNJ-RWJMS, Piscataway, NJ.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 195
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1934 EVALUATION OF SYSTEMIC TOXICITY IN<br />
MIXTURES OF TRICHLOROETHYLENE (TCE),<br />
HEPTACHLOR (HEPT), AND DI(2-<br />
ETHYLHEXYL)PHTHALATE (DEHP) ASSESSED<br />
IN A 5X5X5 DESIGN. J. Simmons 1 , S. Yeatts 2 , J.<br />
Zhao 2 , C. Gennings 2 , A. McDonald 1 and R. MacPhail 1 .<br />
1 NHEERL/ORD, U.S. EPA, Resesarch Triangle Park,<br />
NC and 2 Department Biostatistics, VCU, Richmond,<br />
VA.<br />
#1935 FIRST-PASS EFFECTS ON THE<br />
BIOAVAILABILITY OF HISTAMINE<br />
DIHYDROCHLORIDE. A MULTIPLE-<br />
CANNULAE DOG MODEL FOR<br />
INVESTIGATION OF HEPATIC ELIMINATION.<br />
B. M. Richard 1 , T. M. Tuell 1 , R. R. Lane 1 , J. M. Trang 2 ,<br />
S. Authier 3 , C. A. Zerouala 3 , S. J. Watson 3 , L.<br />
Berryman 3 and S. A. Tonetta 1 . 1 Nonclinical, Maxim<br />
Pharmaceuticals, San Diego, CA, 2 PK/PD, PK/PD<br />
International, Tucson, AZ and 3 <strong>Toxicology</strong>, LAB Pre-<br />
Clinical Research International, Laval, QC, Canada.<br />
Wednesday Afternoon, March 9<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
POSTER SESSION: NEUROTOXICITY, PESTICIDES<br />
Chairperson(s): Nikolay Filipov, Mississippi State University, Mississippi<br />
State, MS and Timothy Shafer, U.S. EPA, Research Triangle Park, NC.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 1:30 PM–3:00 PM<br />
#1936 REACTIVITY AND MODELING STUDIES<br />
PREDICT THAT FLUORINATED<br />
AMINOPHOSPHONATES (FAP) INHIBIT<br />
CHOLINESTERASES (CHE) VIA P—C BOND<br />
CLEAVAGE. G. F. Makhaeva 1 , A. Y. Aksinenko 1 , V. B.<br />
Sokolov 1 , A. N. Razdolsky 1 , N. N. Strakhova 1 , V. V.<br />
Malygin 1 , J. W. Kampf 2 , F. A. Nasser 3 and R. J.<br />
Richardson 3 . 1 Institute <strong>of</strong> Physiologically Active<br />
Compounds RAS, Chernogolovka, Russian Federation,<br />
2 Chemistry Department, University <strong>of</strong> Michigan, Ann<br />
Arbor, MI and 3 EHS Department, <strong>Toxicology</strong> <strong>Program</strong>,<br />
University <strong>of</strong> Michigan, Ann Arbor, MI.<br />
#1937 X-RAY CRYSTAL STRUCTURES OF<br />
FLUORINATED AMINOPHOSPHONATE (FAP)<br />
COMPOUNDS SHOW AN ELONGATED P—C<br />
BOND AND DIMERIZATION. F. A. Nasser 1 , J. W.<br />
Kampf 2 , G. F. Makhaeva 3 , A. Y. Aksinenko 3 , V. B.<br />
Sokolov 3 , N. N. Strakhova 3 , V. V. Malygin 3 and R. J.<br />
Richardson 1 . 1 EHS Department, <strong>Toxicology</strong> <strong>Program</strong>,<br />
University <strong>of</strong> Michigan, Ann Arbor, MI, 2 Chemistry<br />
Department, University <strong>of</strong> Michigan, Ann Arbor, MI<br />
and 3 Institute <strong>of</strong> Physiologically Active Compounds<br />
RAS, Chernogolovka, Russian Federation.<br />
#1938 MASS SPECTOMETRY REVEALS THAT SERINE<br />
ESTERASES ARE PHOSPHORYLATED AND<br />
AGED BY FLUORINATED<br />
AMINOPHOSPHONATE (FAP) COMPOUNDS. N.<br />
D. Miller 1 , J. S. Pierce 1 , P. Glynn 2 , R. M. Worden 3 , J.<br />
Sun 3 , G. F. Makhaeva 4 , A. Y. Aksinenko 4 , V. B.<br />
Sokolov 4 , V. V. Malygin 4 and R. J. Richardson 1 .<br />
1 2 University <strong>of</strong> Michigan, Ann Arbor, MI, University <strong>of</strong><br />
Leicester, Leicester, United Kingdom, 3 Michigan State<br />
University, East Lansing, MI and 4 Institute <strong>of</strong><br />
Physiologically Active Compounds RAS,<br />
Chernogolovka, Russian Federation.<br />
#1939 COMPARISON BETWEEN ELLMAN AND<br />
RADIOMETRIC METHODS FOR ASSESSING<br />
CHOLINESTERASE (CHE) INHIBITION IN RATS<br />
TREATED WITH N-METHYL CARBAMATE<br />
INSECTICIDES. D. L. Hunter 1 , D. Chen 4 , R. S.<br />
Marshall 1 , S. Padilla 1 , W. Setzer 2 , V. C. Moser 1 and A.<br />
Lowit 3 . 1 NTD, U.S. EPA, Research Triangle Park, NC,<br />
2 3 ETD, U.S. EPA, Research Triangle Park, NC, OPP,<br />
U.S. EPA, Arlington, VA and 4 Enloe High School,<br />
Raleigh, NC.<br />
#1940 TIME COURSE AND DOSE RESPONSE<br />
ASSESSMENT OF CHOLINESTERASE (CHE)<br />
INHIBITION IN ADULT RATS TREATED<br />
ACUTELY WITH CARBARYL, METHOMYL,<br />
METHIOCARB, OXAMYL OR PROPOXUR. S.<br />
Padilla 1 , R. S. Marshall 1 , D. L. Hunter 1 , P. Phillips 1 , K.<br />
McDaniel 1 , V. C. Moser 1 and A. Lowit 2 . 1 NTD, U.S.<br />
EPA, Research Triangle Park, NC and 2 OPP, U.S. EPA,<br />
Arlington, VA.<br />
#1941 COMPARISON OF ACUTE NEUROBEHAVIORAL<br />
EFFECTS OF N-METHYL CARBAMATE<br />
INSECTICIDES. V. C. Moser 1 , P. M. Phillips 1 , K. L.<br />
McDaniel 1 , R. S. Marshall 1 , S. Padilla 1 and A. Lowit 2 .<br />
1 NTD/NHEERL, U.S. EPA, Research Triangle Park,<br />
NC and 2 HED/OPP, U.S. EPA, Arlington, VA.<br />
#1942 THE ORGANOPHOSPHOROUS INSECTICIDE<br />
FENTHION DOES NOT AFFECT<br />
PHAGOCYTOSIS OF ROD OUTER SEGMENTS<br />
BY RETINAL PIGMENT EPITHELIUM CELLS<br />
IN CULTURE. A. M. Geller and L. L. Degn.<br />
Neurotoxicology, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#1943 CONCURRENT EXPOSURE TO REPEATED<br />
STRESS AND CHLORPYRIFOS ALTERED NMDA<br />
AND TOTAL MUSCARINIC RECEPTOR<br />
RESPONSES IN HIPPOCAMPUS, CEREBRAL<br />
CORTEX AND HYPOTHALAMUS. T. Pung, K.<br />
Fuhrman, B. Klein, D. Blodgett, B. S. Jortner and M.<br />
Ehrich. Virginia Tech, Blacksburg, VA.<br />
#1944 NEUROTROPHIN CONCENTRATION AFTER IN<br />
VIVO EXPOSURE TO NEUROPATHIC AND NON-<br />
NEUROPATHIC ORGANOPHOSPHATES. M. J.<br />
Pomeroy-Black, M. F. Ehrich and B. S. Jortner.<br />
Laboratory for Neurotoxicity Studies, Department <strong>of</strong><br />
Biomedical Science and Pathobiology, Virginia-<br />
Maryland Regional College <strong>of</strong> Veterinary Medicine,<br />
Blacksburg, VA.<br />
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<strong>Program</strong> Description<br />
#1945 CHLORPYRIFOS INDUCES APOPTOSIS IN<br />
OLIGODENDROCYTE PROGENITOR (CG-4)<br />
CELLS. S. O. Heyliger 1 , M. D. Saulsbury 1 , D. J.<br />
Johnson 1 , D. P. Round 1 , J. K. Morse 1 and S. Green 2 .<br />
1 Pharmaceutical Sciences, Hampton University,<br />
Hampton, VA and 2 Pharmacology, Howard University<br />
School <strong>of</strong> Medicine, Washington, DC.<br />
#1946 ROLE OF A-ESTERASES IN THE AGE-RELATED<br />
DIFFERENCES IN ORGANOPHOSPHATE<br />
DETOXICATION. E. C. Meek 1 , H. Chambers 2 and J.<br />
E. Chambers 1 . 1 Center for Environmental Health<br />
Sciences, Mississippi State University, Mississippi<br />
State, MS and 2 Department <strong>of</strong> Entomology and Plant<br />
Pathology, Mississippi State University, Mississippi<br />
State, MS.<br />
#1947 EFFECT OF ORGANOPHOSPHATE<br />
INSECTICIDE EXPOSURE ON DOPAMINE<br />
METABOLISM IN STRIATAL SLICES. J. A.<br />
Whitehead 1 , E. C. Meek 1 , J. E. Chambers 1 , S. C.<br />
Sistrunk 1 , H. W. Chambers 2 and N. M. Filipov 1 . 1 Center<br />
for Environmental Health Sciences, Coll. Vet. Med.,<br />
Mississippi State University, Mississippi State, MS and<br />
2 Entomology, Mississippi State University, Mississippi<br />
State, MS.<br />
#1948 THIOFLAVIN-T, AN ACETYLCHOLINESTERASE<br />
PERIPHERAL SITE LIGAND, DECREASES<br />
NG108-15 CELL PROLIFERATION. H. M.<br />
Campanha and E. J. Flynn. Pharmacology and<br />
Physiology, UMD-New Jersey Medical School,<br />
Newark, NJ.<br />
#1949 TOXICITY OF CHLORPYRIFOS AND<br />
CHLORPYRIFOS OXON IN A TRANSGENIC<br />
MOUSE MODEL OF THE HUMAN<br />
PARAOXONASE (PON1) Q192R<br />
POLYMORPHISM. T. B. Cole 1,2,3 , B. J. Walter 1 , D.<br />
M. Shih 4 , A. Tward 4 , A. J. Lusis 4 , L. G. Costa 1 and C.<br />
E. Furlong 2,3 . 1 Environmental and Occupational Health<br />
Sciences, University <strong>of</strong> Washington, Seattle, WA,<br />
2 Medicine, Division <strong>of</strong> Medical Genetics, University <strong>of</strong><br />
Washington, Seattle, WA, 3 Genome Sciences,<br />
University <strong>of</strong> Washington, Seattle, WA and<br />
4 Microbiology and Molecular Genetics, UCLA, Los<br />
Angeles, CA.<br />
#1950 EFFECTS OF DIAZINON AND CYPERMETHRIN<br />
ON DIFFERENTIATING NEURONAL AND<br />
GLIAL CELL LINES. M. Sachana 1 , W. Harris 3 , J.<br />
Tack 3 , J. Flaskos 2 and A. J. Hargreaves 3 . 1 Veterinary<br />
Pathology, University <strong>of</strong> Liverpool, Neston, United<br />
Kingdom, 2 Laboratory <strong>of</strong> Biochemistry and <strong>Toxicology</strong>,<br />
Faculty <strong>of</strong> Veterinary Medicine, Aristotelian University,<br />
Thessalonika, Greece and 3 School <strong>of</strong> Science, Faculty<br />
<strong>of</strong> Science and Land Based Studies, Nottingham Trent<br />
University, Nottingham, United Kingdom. Sponsor: R.<br />
Gupta.<br />
#1951 GLUCOSE CONSUMPTION ENHANCES<br />
PARATHION TOXICITY: FUNCTIONAL AND<br />
NEUROCHEMICAL CORRELATES. J. Liu, A.<br />
Abbey and S. Karanth. Physiological Sciences,<br />
Oklahoma State University, Stillwater, OK.<br />
#1952 IMMEDIATE EARLY ALTERATION AND<br />
DIFFERENTIAL PERSISTENCE OF PKA<br />
(PROTEIN KINASE A) / P-CREB<br />
(PHOSPHORYATED CREB) PATHWAY IN THE<br />
CENTRAL NERVOUS SYSTEM OF HENS<br />
DEVELOPING DELAYED NEUROTOXICITY<br />
(OPDIN) BY A SINGLE DOSE OF<br />
DIISOPROPYLPHOSPHOROFLUORIDATE (DFP)<br />
TREATMENT. T. V. Damodaran, R. Gupta and M.<br />
Abou-Donia. Pharmacology/ Pediatrics, Duke<br />
University Medical Center, Durham, NC.<br />
#1953 ACTIONS OF PYRETHROID INSECTICIDES ON<br />
THE SPONTANEOUS RELEASE OF<br />
GLUTAMATE FROM CULTURED<br />
HIPPOCAMPAL NEURONS. D. A. Meyer 2 and T. J.<br />
Shafer 1 . 1 Neurotoxicology Division, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC and 2 Curriculum<br />
in <strong>Toxicology</strong>, University <strong>of</strong> North Carolina at Chapel<br />
Hill, Chapel Hill, NC.<br />
#1954 EFFECT OF PYRETHROIDS ON GLUTAMATE<br />
RELEASE IN THE HIPPOCAMPUS OF FREELY<br />
MOVING RATS. H. Kobayashi 1,3 , M. M. Hossain 1,3 ,<br />
T. Suzuki 1,3 , I. Sato 1,3 , T. Takewaki 3 and K. Suzuki 2 .<br />
1 Veterinary Medicine, Iwate University, Morioka, Iwate,<br />
Japan, 2 Agro-bioscience, Iwate University, Morioka,<br />
Iwate, Japan and 3 United Graduate School <strong>of</strong> Veterinary<br />
Sciences, Gifu University, Gifu, Japan. Sponsor: G.<br />
Corcoran.<br />
#1955 EFFECTS OF EXPOSURE TO THE PESTICIDE<br />
ATRAZINE ON STRIATAL NEUROCHEMISTRY<br />
IN MALE C57BL/6 MICE ARE AGE-<br />
DEPENDENT. N. M. Filipov, A. Coban, S. C. Sistrunk<br />
and A. B. Norwood. Center for Environmental Health<br />
Sciences, Basic Sciences, Coll. Vet. Med., Mississippi<br />
State University, Mississippi State, MS.<br />
#1956 EFFECTS OF 14-DAY EXPOSURE TO THE<br />
HERBICIDE ATRAZINE ON DOPAMINE<br />
NEURONS IN THE SUBSTANTIA NIGRA AND<br />
VENTRAL TEGMENTAL AREA OF JUVENILE<br />
MALE C57BL/6 MICE. A. Coban, A. B. Norwood<br />
and N. M. Filipov. Center for Environmental Health<br />
Sciences, Basic Sciences, Coll. Vet. Med., Mississippi<br />
State University, Mississippi State, MS.<br />
#1957 DECREASE OF THE STRIATAL DOPAMINE<br />
RELEASE CAUSED BY ACUTE ATRAZINE<br />
EXPOSURE IS BLOCKED BY HALOPERIDOL<br />
ADMINISTRATION. V. M. Rodriguez, M.<br />
Thiruchelvam and D. A. Cory-Slechta. Environmental<br />
and Community Medicine, Environmental and<br />
Occupational Health Sciences Institute, The University<br />
<strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey and Rutgers,<br />
Piscataway, NJ.<br />
#1958 GENDER DIFFERENCES IN A PESTICIDE<br />
MODEL OF PARKINSON’S DISEASE. M.<br />
Thiruchelvam, H. Mehta, B. Winnik, B. Buckley, E. K.<br />
Richfield and D. A. Cory-Slechta. EOHSI,<br />
UMDNJ–Robert Wood Johnson Medical School,<br />
Piscataway, NJ.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 197
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
WEDNESDAY<br />
#1959 SIGNALING PATHWAYS OF PARAQUAT-<br />
INDUCED APOPTOSIS: A MODEL FOR<br />
PARKINSON’S DISEASE. H. M. Klintworth 1 and Z.<br />
Xia 1,2 . 1 Env. & Occ. Health Sciences, University <strong>of</strong><br />
Washington, Seattle, WA and 2 Phamacology, University<br />
<strong>of</strong> Washington, Seattle, WA.<br />
#1960 THE ORGANOCHLORINE PESTICIDE<br />
METHOXYCHLOR ALTERS BRAIN<br />
MITOCHONDRIAL RESPIRATION, H 2 O 2<br />
PRODUCTION AND CALCIUM/CAMP<br />
RESPONSE ELEMENT BINDING PROTEIN<br />
LEVELS. R. A. Schuh 3,1 , T. Kristian 1 , J. Flaws 3 and G.<br />
Fiskum 1 . 1 Anesthesiology, University <strong>of</strong> Maryland<br />
Baltimore, Baltimore, MD, 2 Anesthesiology, University<br />
<strong>of</strong> Maryland Baltimore, Baltimore, MD, 3 Epidemiology<br />
and Experimental Therapeutics, University <strong>of</strong> Maryland<br />
Baltimore, Baltimore, MD and 4 Anesthesiology,<br />
University <strong>of</strong> Maryland Baltimore, Baltimore, MD.<br />
#1961 DIELDRIN EXPOSURE CAUSES OXIDATIVE<br />
DAMAGE IN DOPAMINE NEURONS. J. M.<br />
Hatcher 1 , T. S. Guillot 1 , J. R. Richardson 1,2 and G. W.<br />
Miller 1,2 . 1 Center for Neurodegerative Disease, Emory<br />
University, Atlanta, GA and 2 Environmental and<br />
Occupational Health, Rollins School <strong>of</strong> Public Health,<br />
Emory University, Atlanta, GA.<br />
#1962 MECHANISM OF SELECTIVE TOXICITY OF<br />
IVERMECTIN IN INSECTS AND MAMMALS. T.<br />
Narahashi 1 , X. Zhao 1 , V. L. Salgado 2 and J. Z. Yeh 1 .<br />
1 Molecular Pharmacology and Biological Chemistry,<br />
Northwestern University Medical School, Chicago, IL<br />
and 2 Bayer CropScience, Global Biology Insecticides,<br />
Monheim, Germany.<br />
#1963 SULFONE METABOLITE OF FIPRONIL<br />
BLOCKS GABA- AND GLUTAMATE-<br />
ACTIVATED CHLORIDE CHANNELS IN<br />
MAMMALIAN AND INSECT NEURONS. X. Zhao 1 ,<br />
J. Z. Yeh 1 , V. L. Salgado 2 and T. Narahashi 1 .<br />
1 Molecular Pharmacology and Biological Chemistry,<br />
Northwestern University Medical School, Chicago, IL<br />
and 2 Bayer CropScience, Global Biology Insecticides,<br />
Monheim, Germany.<br />
#1964 IMMORTALIZED MICROGLIAL CELLS AS A<br />
MODEL SYSTEM FOR OXIDATIVE STRESS:<br />
PESTICIDE-INDUCED GENOMIC CHANGES. J.<br />
E. Royland 1 , P. R. Kodavanti 1 , M. Pooler 2 , O.<br />
Makwana 2 and B. Veronesi 1 . 1 Neurotoxicology<br />
Division, U.S. EPA, Durham, NC and 2 <strong>Toxicology</strong><br />
<strong>Program</strong>, NC State University, Raleigh, NC.<br />
#1965 NEUROTOXIC EFFECTS OF MANCOZEB AND<br />
MANEB IN VIVO AND IN VITRO. L. M. Domico 1,<br />
2 , G. Zeevalk 2 , M. Thiruchelvam 2 and K. R. Cooper 1 .<br />
1 Joint Graduate <strong>Program</strong> in <strong>Toxicology</strong>, Rutgers, The<br />
State University <strong>of</strong> New Jersey, Piscataway, NJ and<br />
2 University <strong>of</strong> Medicine and Dentistry <strong>of</strong> New Jersey,<br />
Piscataway, NJ.<br />
#1966 EFFECT OF PYRETHROIDS ON GABA<br />
RELEASE IN THE HIPPOCAMPUS OF FREELY<br />
MOVING RATS. M. M. Hossain 1,3 , T. Suzuki 1,3 , I.<br />
Sato 1,3 , T. Takewaki 3 , K. Suzuki 2 and H. Kobayashi 1,3 .<br />
1 Veterinary Medicine, Iwate University, Morioka, Iwate,<br />
Japan, 2 Agro-bioscience, Iwate University, Morioka,<br />
Iwate, Japan and 3 United Graduate School <strong>of</strong> Veterinary<br />
Sciences, Gifu University, Gifu, Japan. Sponsor: G.<br />
Corcoran.<br />
#1967 EFFECTS OF PHENYL SALYGENIN<br />
PHOSPHATE (PSP) AND PHENYLMETHANE<br />
SULFONYL FLUORIDE (PMSF) ON RAT<br />
DORSAL ROOT GANGLIA (DRG) CULTURES. E.<br />
Brigo 1 , A. Moretto 1 , P. Glynn 2 , D. E. Read 2 and M.<br />
Lotti 1 . 1 Medicina del Lavoro, Universita’ di Padova,<br />
Padova, Italy and 2 <strong>Toxicology</strong> Unit, MRC, Leicester,<br />
United Kingdom.<br />
Abstract 1968 is located on page 200.<br />
Wednesday Afternoon, March 9<br />
4:30 PM to 6:00 PM<br />
Room 207<br />
SUNSET SESSION: ADVANCES IN MATERIAL SAFETY DATA<br />
SHEET COMMUNICATION<br />
Chairperson(s): Melissa McDiarmid, University <strong>of</strong> Maryland, Baltimore, MD<br />
and James Bus, Dow Chemical Company, Midland, MI.<br />
Endorsed by:<br />
Occupational and Public Health SS*<br />
Regulatory and Safety Evaluation SS<br />
Risk Assessment SS<br />
OSHA is currently reviewing its Material Safety Data Sheets (MSDS) requirements,<br />
as is the American National Standards Institute (ANSI). Employers using<br />
hazardous chemicals are required by OSHA’s Hazard Communications Standard<br />
to have MSDSs available to workers. Developing and providing effective<br />
communication is a major challenge within the public health and occupational<br />
health communities. Some MSDSs are difficult for workers to read; some<br />
MSDSs are outdated; and some MSDSs omit needed health information. On the<br />
other hand, some manufacturers produce what might be considered examples <strong>of</strong><br />
“best practice” MSDS writing: excellent, readable, and timely information.<br />
Another source <strong>of</strong> information, the New Jersey Hazardous Substances Fact<br />
Sheets, covers only about 1, 600 workplace chemicals. However, the program<br />
receives 80, 000 hits per month on its website for its fact sheets, which are<br />
considered by many environmental and labor advocates to be good sources <strong>of</strong><br />
essential health and safety information. The message that reproductive health<br />
includes both men and women, and that it can be affected by their workplace<br />
exposures, needs to reach the workers and their employers through MSDS<br />
communication. Paul and Kurtz surveyed Massachusetts MSDSs in 1994 for<br />
products containing two known reproductive toxicants, lead and glycol ethers,<br />
and found that over 60% did not mention possible reproductive health effects.<br />
They also found that where reproductive hazards were mentioned in MSDSs,<br />
they were 18 times more likely to address developmental effects than male<br />
reproductive risks. How can MSDS writing be improved to a best practice standard<br />
while avoiding national or international standards conflicts? The NIOSH<br />
Reproductive Health Research Team is interested in finding ways to improve the<br />
quality <strong>of</strong> MSDSs in general, and particularly the quality <strong>of</strong> reproductive health<br />
information. Representatives from NIOSH, industry, academia, and the New<br />
Jersey Right to Know <strong>Program</strong> will present and discuss multiple facets <strong>of</strong> this<br />
issue.<br />
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and ToxExpo<br />
<strong>Program</strong> Description<br />
#1664 4:30 ADVANCES IN MATERIAL SAFETY DATA<br />
SHEET COMMUNICATION. M. McDiarmid 1 and L.<br />
Frazier 2 . 1 Occupational Health Project, University <strong>of</strong><br />
Maryland, Baltimore, MD and 2 Department <strong>of</strong><br />
Preventive Medicine, University <strong>of</strong> Kansas School <strong>of</strong><br />
Medicine, Wichita, KS.<br />
#1665 4:40 ISSUES WITH MSDS COMMUNICATION OF<br />
REPORDUCTIVE HAZARDS. L. Frazier 1,2 , M. J.<br />
Rall 2 and D. B. Fromer 1 . 1 Preventive Medicine and<br />
Public Health, University <strong>of</strong> Kansas School <strong>of</strong><br />
Medicine-Wichita, Wichita, KS and 2 Obstetrics and<br />
Gynecology, University <strong>of</strong> Kansas School <strong>of</strong> Medicine-<br />
Wichita, Wichita, KS. Sponsor: M. McDiarmid.<br />
#1666 5:00 DEVELOPING GOOD MSDS<br />
COMMUNICATIONS IN INDUSTRY. J. S. Bus. The<br />
Dow Chemical Company, Midland, MI.<br />
#1667 5:20 MSDSS IN CANADA AND THE<br />
COMMUNICATION OF REPRODUCTIVE<br />
TOXICITY. P. Demers. School <strong>of</strong> Occ/Env Hygiene,<br />
University <strong>of</strong> British Columbia, Vancouver, BC,<br />
Canada. Sponsor: M. McDiarmid.<br />
#1668 5:40 STRENGTHS OF THE NJ HAZARDOUS<br />
SUBSTANCE FACT SHEET PROGRAM: HOW<br />
TO WRITE A BETTER MSDS. R. Willinger, JD<br />
MPH and A. Sobieszczyk, MD PhD. Right to Know<br />
<strong>Program</strong>, New Jersey Department <strong>of</strong> Health and Senior<br />
Services, Trenton, NJ. Sponsor: B. Grajewski.<br />
Wednesday Afternoon, March 9<br />
4:30 PM to 6:00 PM<br />
Room 208<br />
#1670 4:32 IMPROVED NUTRITION THROUGH MODERN<br />
BIOTECHNOLOGY. M. Newell–McGloughlin.<br />
University <strong>of</strong> California Systemwide Biotechnology<br />
Research and Education <strong>Program</strong>, U.C. Davis, Davis,<br />
CA. Sponsor: B. Hammond.<br />
#1671 4:47 CASE STUDY FOR THE SAFETY ASSESSMENT<br />
OF A NUTRITIONALLY IMPROVED<br />
FEED/FOOD CROP. B. G. Hammond, T. Reynolds, G.<br />
Hartnell, E. Rice, R. McCoy and K. Glenn. Product<br />
Safety Center, Monsanto Company, St. Louis, MO.<br />
#1672 5:02 SAFETY ASSESSMENT OF NUTRITIONALLY<br />
IMPROVED CROPS THROUGH MODERN<br />
BIOTECHNOLOGY. H. A. Kuiper, G. A. Kleter and<br />
E. J. Kok. RIKILT, Institute <strong>of</strong> Food Safety,<br />
Wageningen University and Research Center,<br />
Wageningen, Netherlands. Sponsor: B. Hammond.<br />
#1673 5:22 SAFETY AND NUTRITIONAL ASSESSMENT OF<br />
FOODS AND FEEDS NUTRITIONALLY<br />
IMPROVED THROUGH BIOTECHNOLOGY. I. C.<br />
Munro. CANTOX Health Sciences International,<br />
Mississauga, ON, Canada.<br />
Wednesday Afternoon, March 9<br />
4:30 PM to 6:00 PM<br />
Room 220<br />
SUNSET SESSION: VINYL CHLORIDE: LEGACY AND LESSONS<br />
LEARNED<br />
Chairperson(s): Roger O. McClellan, <strong>Toxicology</strong> and Human Health Risk<br />
Analysis, Albuquerque, NM and Melvin Andersen, CIIT Centers for Health<br />
Research, Research Triangle Park, NC.<br />
SUNSET SESSION: THE SAFETY ASSESSMENT OF<br />
NUTRITIONALLY IMPROVED FOOD AND FEED CROPS<br />
Chairperson(s): Bruce Hammond, Monsanto, St. Louis, MO and Philip M.<br />
Bolger, U.S. FDA, College Park, MD.<br />
Endorsed by:<br />
Food Safety SS*<br />
Regulatory and Safety Evaluation SS<br />
Student Advisory Committee<br />
The first generation <strong>of</strong> food and feed crops developed through modern agricultural<br />
biotechnology were designed to improve agronomic characteristics such as<br />
control <strong>of</strong> noxious weeds (herbicide tolerance) or protection against insect pests.<br />
The next generation <strong>of</strong> products under development include crops that have<br />
improved nutritional characteristics. Speakers for this workshop will discuss (1)<br />
various biotechnology approaches that are being used to improve nutritional<br />
characteristics <strong>of</strong> feed/food crops, (2) a case study for the safety and nutritional<br />
assessment <strong>of</strong> a nutritionally improved food/feed crop (3) recommendations <strong>of</strong><br />
the EU ENTRANSFOOD working group on safety assessment <strong>of</strong> foods derived<br />
from genetically modified crops (4) conclusions from a recent ILSI workshop<br />
entitled Nutritional and Safety Assessments <strong>of</strong> Foods and Feeds Nutritionally<br />
Improved through Biotechnology. At the end <strong>of</strong> the presentations, a panel<br />
discussion will compare and contrast recommendations from the SOT,<br />
ENTRANSFOOD and ILSI workgroups regarding the safety assessment <strong>of</strong><br />
nutritionally improved crops.<br />
#1669 4:30 THE SAFETY ASSESSMENT OF<br />
NUTRITIONALLY IMPROVED FOOD AND FEED<br />
CROPS. B. G. Hammond. Product Safety Center,<br />
Monsanto Company, St. Louis, MO.<br />
Endorsed by:<br />
Biological Modeling SS<br />
Carcinogenesis SS<br />
Comparative and Veterinary SS<br />
Risk Assessment SS*<br />
Vinyl chloride is a major commodity chemical that has been extensively studied<br />
relative to its toxicological and carcinogenic properties. Early research<br />
conducted by producers and users <strong>of</strong> vinyl chloride focused on its toxicological<br />
properties. The research results were used in a standard safety factor framework<br />
to derive threshold limit values for occupational exposure. Long-term rodent<br />
inhalation studies were initiated to investigate the potential for chronic toxicity<br />
and carcinogenicity. Almost concurrently, carcinogenic responses were<br />
observed in the rodent studies and case reports were published on a finding <strong>of</strong><br />
a rare cancer, hepatic angiosarcomas in workers exposed to high levels <strong>of</strong> vinyl<br />
chloride. More stringent occupational exposure limits were instituted and<br />
further research on vinyl chloride initiated. This included epidemiological<br />
studies <strong>of</strong> workers, animal carcinogenicity bioassays and mechanistic investigations.<br />
The initial results, while confirming the carcinogenicity <strong>of</strong> vinyl chloride<br />
in humans and rodents, appeared to yield marked differences in carcinogenic<br />
potency in humans and rodents. Further research on the metabolic kinetics and<br />
molecular dosimetry <strong>of</strong> vinyl chloride and its metabolites provided a basis for<br />
reconciling the original apparent species differences in potency and provided a<br />
mechanistic basis for the very specific carcinogenic response, hepatic angiosarcomas.<br />
The more stringent exposure standards have been effective in protecting<br />
workers. In retrospect, the research conducted on vinyl chloride may be viewed<br />
as a success story for how mechanism-based findings can be used to establish<br />
appropriate health protective standards. Moreover, the research approach used<br />
with vinyl chloride has served as a template for evaluating the toxicity and<br />
carcinogenicity <strong>of</strong> other chemicals.<br />
WEDNESDAY<br />
up-to-date information at www.toxicology.org 199
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1674 4:30 VINYL CHLORIDE: LEGACY AND LESSONS<br />
LEARNED. R. O. McClellan. <strong>Toxicology</strong> and Human<br />
Health Risk Analysis, Albuquerque, NM.<br />
#1675 4:40 METABOLISM OF VINYL HALIDES AND<br />
REACTIONS OF ELECTROPHILIC PRODUCTS.<br />
F. P. Guengerich. Biochemistry and Center in Molecular<br />
<strong>Toxicology</strong>, Vanderbilt University, Nashville, TN.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room RO4<br />
Thursday Morning<br />
WEDNESDAY<br />
#1676 5:00 VINYL CHLORIDE: ESTABLISHING THE ROLE<br />
OF DOSIMETRY IN RISK ASSESSMENT. M. E.<br />
Andersen. CIIT Centers for Health Research, Research<br />
Triangle Park, NC.<br />
#1677 5:20 VINYL CHLORIDE: TOXICOLOGICAL AND<br />
CARCINOGENIC RESPONSES IN HUMANS AND<br />
LABORATORY ANIMALS. R. O. McClellan.<br />
<strong>Toxicology</strong> and Human Health Risk Analysis,<br />
Albuquerque, NM.<br />
Abstract 1678 is located on page 178<br />
Wednesday Afternoon, March 9<br />
4:45 PM to 5:30 PM<br />
Room 213<br />
SOT COUNCIL MEETING WITH STUDENTS/POST-DOCTORAL<br />
FELLOWS<br />
All students and post-doctoral fellows are encouraged to attend this meeting,<br />
which provides as a two-way dialog between SOT Council and students.<br />
Wednesday Evening<br />
Wednesday Evening, March 9<br />
6:00 PM to 7:30 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
SPECIALTY SECTION MEETINGS:<br />
COMPARATIVE AND VETERINARY, DERMAL, DRUG DISCOVERY,<br />
FOOD SAFETY, MOLECULAR BIOLOGY, REPRODUCTIVE AND<br />
DEVELOPMENTAL, WOMEN IN TOXICOLOGY.<br />
Wednesday Evening, March 9<br />
6:00 PM to 11:00 PM<br />
See Events Calendar on Pages 2–6 for Room Listings<br />
REGIONAL CHAPTER MEETINGS/RECEPTIONS<br />
Many <strong>of</strong> the Regional Chapters meet during the SOT Annual Meeting. Details<br />
for these Regional Chapter receptions and meetings are listed in <strong>Program</strong>’s<br />
Events Calendar.<br />
SYMPOSIUM SESSION: CROSS-SPECIES TOXICOLOGY IN THE<br />
AGE OF GENOMICS<br />
Chairperson(s): William B. Mattes, Gene Logic Inc., Gaithersburg, MD and<br />
Timothy P. Ryan, Eli Lilly and Company, Greenfield, IN.<br />
Endorsed by:<br />
National Capital Area Chapter<br />
Risk Assessment SS<br />
While animal models have been the cornerstone <strong>of</strong> experimental toxicology and<br />
safety assessment for the last two centuries, the question <strong>of</strong>ten arises whether<br />
the results seen in one species are relevant to what may be expected in another,<br />
particularly when the extrapolation is being made to man. Genomic information<br />
could change this problem dramatically. At one level, comparisons <strong>of</strong> coding<br />
regions and upstream regulatory regions across genomes can provide clues as to<br />
similarities and differences between species vis-à-vis the molecular components<br />
<strong>of</strong> a cell and their regulation. One example where this approach has provided<br />
valuable insights is the nuclear receptor gene family. These genomic comparisons<br />
can also be used to inform the use <strong>of</strong> non-mammalian models <strong>of</strong> toxicity<br />
such as Caenorhabditis elegans. Complementary to such genomic comparisons,<br />
mRNA pr<strong>of</strong>iling with microarrays allows a global view <strong>of</strong> toxicant-induced<br />
transcriptome alterations in various cell types, tissues and species, and allows an<br />
experimental view <strong>of</strong> similarities and differences in signaling and response pathways.<br />
Thus transcriptome alterations can be compared in vivo between rat and<br />
canine models, and in vitro between rat, canine, and human hepatocytes. The<br />
promise is that such tools will allow for any given toxic response a truly molecular<br />
assessment <strong>of</strong> the relevance <strong>of</strong> various animal models to one another and to<br />
man.<br />
#1968 8:30 CROSS-SPECIES TOXICOLOGY IN THE AGE<br />
OF GENOMICS. W. B. Mattes 1 and T. P. Ryan 2 .<br />
1 Toxicogenomics, Gene Logic Inc., Gaithersburg, MD<br />
and 2 Investigative <strong>Toxicology</strong>, Eli Lily and Company,<br />
Greenfield, IN.<br />
#1969 8:40 INSIGHTS INTO EVOLUTION OF XENOBIOTIC<br />
METABOLISM IN MAMMALS FROM<br />
COMPARATIVE GENOMICS OF THE NUCLEAR<br />
RECEPTOR GENE FAMILY. D. A. Wheeler 1,2 , A. J.<br />
Cooney 3 and Z. Zhang 1 . 1 Human Genome Sequencing<br />
Center, Baylor College <strong>of</strong> Medicine, Houston, TX,<br />
2 Molecular and Human Genetics, Baylor College <strong>of</strong><br />
Medicine, Houston, TX and 3 Molecular and Cellular<br />
Biology, Baylor College <strong>of</strong> Medicine, Houston, TX.<br />
Sponsor: W. Mattes.<br />
#1970 9:05 COMPUTATIONAL AND EMPIRICAL<br />
INVESTIGATION OF ESTROGEN AND DIOXIN<br />
ELICITED EFFECTS: A COMPARATIVE<br />
ANALYSIS. T. Zacharewski. Biochemistry &<br />
Molecular Biology, Center for Integrative <strong>Toxicology</strong>,<br />
National Food Safety & <strong>Toxicology</strong> Center, Michigan<br />
State University, East Lansing, MI.<br />
#1971 9:30 GENOMIC CHARACTERIZATION OF THE<br />
ACUTE PHASE RESPONSE IN MICE, DOGS,<br />
AND RATS. T. P. Ryan. Investigative <strong>Toxicology</strong>, Eli<br />
Lily and Company, Greenfield, IN.<br />
200<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1972 9:55 CROSS-SPECIES COMPARISONS OF<br />
TRANSCRIPTIONAL RESPONSES IN PRIMARY<br />
HEPATOCYTES. W. B. Mattes, K. Daniels, D. L.<br />
Mendrick and M. S. Orr. Toxicogenomics, Gene Logic<br />
Inc., Gaithersburg, MD.<br />
#1973 10:20 TOXICO- AND PHARMACOGENETIC ANALYSIS<br />
IN A NOVEL MODEL OF PARKINSON’S<br />
DISEASE: DOPAMINE NEURON<br />
DEGENERATION IN C. ELEGANS. R. Nass, C.<br />
Nichols, M. Fullard, M. Garrett and M. Marvanova.<br />
Anesthesiology and Pharmacology, and Center for<br />
Molecular Neuroscience, Vanderbilt University Medical<br />
Center, Nashville, TN. Sponsor: B. Mattes.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room 208<br />
SYMPOSIUM SESSION: DEVELOPMENTAL EXPRESSION OF<br />
HUMAN PHASE I AND PHASE II TOXICANT METABOLIZING<br />
ENZYMES: IMPACT ON EARLY LIFE STAGE SUSCEPTIBILITY<br />
Chairperson(s): Ronald Hines, Medical College <strong>of</strong> Wisconsin, Milwaukee, WI<br />
and Melissa A. Runge-Morris, Wayne State University, Detroit, MI.<br />
Endorsed by:<br />
Mechanisms SS<br />
Risk Assessment SS<br />
Student Advisory Committee<br />
Over the past several years, there has been considerable interest in the dynamic<br />
changes that occur in toxicokinetic factors during early life stages and how these<br />
changes may impact differential toxicant susceptibility. Advances in molecular<br />
and analytical techniques have allowed a better characterization <strong>of</strong> these<br />
changes, as well as some <strong>of</strong> the underlying control mechanisms. The objectives<br />
<strong>of</strong> this symposium are to: 1) present examples <strong>of</strong> the information gained about<br />
major members <strong>of</strong> the oxidative Phase I enzymes and how this information has<br />
led to the identification <strong>of</strong> common developmental themes; 2) present information<br />
on the developmental expression <strong>of</strong> two conjugative phase II enzyme<br />
classes, N-acetyl transferases and sulfotransferases, and how, combined with the<br />
information regarding phase I enzymes, can inform regarding possible differential<br />
susceptibility during ontogeny; and 3) demonstrate how such information<br />
regarding developmental expression can be integrated into physiological-based<br />
toxicokinetic models for predicting temporal-specific changes in toxicant disposition<br />
useful for early life stage risk assessment. These advances <strong>of</strong>fer the<br />
promise and challenge <strong>of</strong> predicting changing dose-response relationships<br />
during early life and the possible prevention <strong>of</strong> developmental toxicity.<br />
#1974 8:30 ONTOGENY OF HUMAN HEPATIC PHASE I<br />
AND PHASE II ENZYMES: IMPLICATIONS FOR<br />
DIFFERENTIAL TOXICANT SUSCEPTIBILITY.<br />
R. N. Hines 1 and M. A. Runge-Morris 2 . 1 Pediatrics,<br />
Medical College <strong>of</strong> Wisconsin, Milwaukee, WI and<br />
2 Inst. Env. Hlth. Sciences., Wayne State University,<br />
Detroit, MI.<br />
#1975 8:35 HUMAN HEPATIC PHASE I ENZYME<br />
DEVELOPMENTAL EXPRESSION. R. N. Hines.<br />
Pediatrics, Med. Col. Wisconsin, Milwaukee, WI.<br />
#1976 9:15 SULFOTRANSFERASE EXPRESSION:<br />
IMPLICATIONS FOR PRENATAL TOXICITY. M.<br />
Runge-Morris. Inst. Envir. Health Sciences., Wayne<br />
State University, Detroit, MI.<br />
#1977 9:55 DEVELOPMENTAL EXPRESSION OF HUMAN<br />
AND MURINE ARYLAMINE N-<br />
ACETYLTRANSFERASES(NAT):<br />
IMPLICATIONS FOR AROMATIC AMINE<br />
GENOTOXICITY. C. A. McQueen. University <strong>of</strong><br />
Arizona, Tucson, AZ.<br />
#1978 10:35 DEVELOPMENT OF PHYSIOLOGICALLY-<br />
BASED TOXICOKINETIC MODELS FOR EARLY<br />
LIFE STAGES: IMPLICATIONS FOR<br />
DIFFERENTIAL TOXICANT SUSCEPTIBILITY.<br />
D. Hattis 1 , G. Ginsberg 2 , B. Sonawane 3 and K. Walker 4 .<br />
1 2 Clark University, Worcester, MA, CT Department <strong>of</strong><br />
Public Health, Hartford, CT, 3 U.S. EPA, Washington,<br />
DC and 4 Clark University, Worcester, MA.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room 220<br />
SYMPOSIUM SESSION: SYSTEMS BIOLOGY: APPROACHES AND<br />
APPLICATIONS TO TOXICOLOGY<br />
Chairperson(s): William Slikker, Jr., National Center for Toxicological<br />
Research, Jefferson, AR and Thomas Knudsen, University <strong>of</strong> Louisville, School<br />
<strong>of</strong> Dentistry, Louisville, KY.<br />
Endorsed by:<br />
Neurotoxicology SS<br />
Reproductive and Development SS<br />
Risk Assessment SS*<br />
Genomics and proteomics provide information on the cellular reaction to drug<br />
and chemical exposures but this is only part <strong>of</strong> what is needed to understand<br />
complex developing systems, where susceptibilities to exposure may advance<br />
through transitional states <strong>of</strong> varying susceptibilities. The NIH Director’s Road<br />
Map has focused on the need to provide new tools to investigators, to speed the<br />
process <strong>of</strong> discovery, to encourage interdisciplinary research, and to promote<br />
translational research. Systems biology will contribute to this missive. Systems<br />
biology is the application <strong>of</strong> systems theory to solving biological problems and<br />
is a means to analyze complex behavior in a composite system that may be<br />
decomposed into subsystems to facilitate understanding and modeling. In toxicology,<br />
it provides a means for identifying pathways that are critical to disease<br />
and to discovering on- and <strong>of</strong>f- target effects <strong>of</strong> compounds. Devising computational<br />
models and integrating these models with empirical data provide<br />
important insight into complex systems-level behaviors, ultimately striving to<br />
deliver the mechanism connecting small molecules (drug or chemical) with a<br />
clinical endpoint (phenotype or disease) with regards to metabolic and regulatory<br />
networks. The integrative topic <strong>of</strong> systems biology and application<br />
examples focused on several organ systems and stages <strong>of</strong> development will<br />
interests toxicologists with backgrounds in mechanisms, reproduction, development,<br />
neuroscience, modeling, and safety and risk assessment.<br />
#1979 8:30 SYSTEMS BIOLOGY: APPROACHES AND<br />
APPLICATIONS TO TOXICOLOGY. W. Slikker 1<br />
and T. B. Knudsen 2 . 1 Division <strong>of</strong> Neurotoxicology,<br />
NCTR/FDA, Jefferson, AR and 2 Department <strong>of</strong><br />
Molecular, Cellular and Crani<strong>of</strong>acial Biology Birth<br />
Defects Center, University <strong>of</strong> Lousiville, School <strong>of</strong><br />
Dentistry, Louisville, KY.<br />
#1980 9:00 EXTRACTING MEANING FROM EXPRESSION<br />
DATA. J. Quackenbush. Institute for Genomic<br />
Research, Rockville, MD. Sponsor: T. Knudsen.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 201
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#1981 9:30 MODELING GENE NETWORKS IN THE<br />
NEURONAL ADAPTATION TO ALCOHOL. J. S.<br />
Schwaber. Department <strong>of</strong> Pathology, Anatomy and Cell<br />
Biology, Thomas Jefferson University, Philadelphia, PA.<br />
Sponsor: W. Slikker.<br />
#1982 10:00 SYSTEMS BIOLOGY AND DOSE RESPONSE<br />
ASSESSMENT. M. Andersen. Division <strong>of</strong><br />
Biomathematics and Physical Sciences, CIIT, Research<br />
Triangle Park, NC.<br />
#1983 10:30 AN ±OMICS± APPROACH TO ELUCIDATE<br />
MECHANIMS OF DISRUPTED<br />
NEPHROGENESIS AND FUNCTIONAL<br />
INTERACTIONS BETWEEN AHR AND<br />
WILMS±TUMOR SUPPRESSOR GENE. K. S.<br />
Ramos. Department <strong>of</strong> Biochemistry and Molecular<br />
Biology, University <strong>of</strong> Louisville, Louisville, KY.<br />
#1984 11:00 COMPUTATIONAL SYSTEMS ANALYSIS OF<br />
DEVELOPMENTAL TOXICITY. T. B. Knudsen and<br />
A. V. Singh. Department <strong>of</strong> Molecular, Cellular and<br />
Crani<strong>of</strong>acial Biology, University <strong>of</strong> Louisville,<br />
Louisville, KY.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room RO8<br />
WORKSHOP SESSION: CELLULAR/MOLECULAR MECHANISMS<br />
INVOLVED IN ENVIRONMENTAL CHEMICALS- INDUCED<br />
DOPAMINERGIC NEUROTOXICITY AND THE CONSEQUENCES ON<br />
NEURODEGENERATIVE DISEASES<br />
Chairperson(s): Anumantha Kanthasamy, Iowa State University, Ames, IA<br />
and Syed F. Ali, NCTR FDA, Little Rock, AR.<br />
Endorsed by:<br />
Neurotoxicology SS*<br />
Student Advisory Committee<br />
#1985 8:30 CELLULAR/MOLECULAR MECHANISMS<br />
INVOLVED IN ENVIRONMENTAL CHEMICALS-<br />
INDUCED DOPAMINERGIC NEUROTOXICITY<br />
AND THE CONSEQUENCES ON<br />
NEURODEGENERATIVE DISEASES. A. G.<br />
Kanthasamy. Iowa State University, Ames, IA.<br />
#1986 8:35 OXIDATIVE STRESS-SENSITIVE KINASE IN<br />
NEUROTOXINS-INDUCED SELECTIVE<br />
DOPAMINERGIC CELL DEATH: RELEVANCE<br />
TO PARKINSON’S DISEASE. A. G. Kanthasamy.<br />
Biomedical Sciences, Iowa State University, Ames, IA.<br />
#1987 9:15 ROLE OF PROINFLAMATORY CYTOKINES IN<br />
CHEMICALLY-INDUCED DOPAMINERGIC<br />
NEURODEGERATION. J. O’Callaghan.<br />
Neurotoxicology Laboratory, CDC/NIOSH,<br />
Morgantown, WV.<br />
#1988 9:55 BIOLOGICAL BASES FOR PCB INDUCED<br />
ALTERATION IN DOPAMINE-MEDIATED<br />
NEUROLOGICAL FUNCTION. R. F. Seegal 2 , K. L.<br />
Marek 3 , S. A. Factor 4 , R. J. McCaffrey 5 , R. F. Hasse 5<br />
and A. G. Kanthasamy 1 . 1 Biomedical Sciences, Iowa<br />
State University, Ames, IA, 2 New York State<br />
Department <strong>of</strong> Health, Wadsworth Center, Albany, NY,<br />
3 Institute <strong>of</strong> Neurodegenerative Disorders, New Haven,<br />
CT, 4 Albany Medical Center, Albany, NY and<br />
5 University <strong>of</strong> Albany, Albany, NY.<br />
#1989 10:35 ROLE OF NITRIC OXIDE IN<br />
METHAMPHETAMINE-INDUCED<br />
DOPAMINERGIC NEUROTOXICITY IN MICE. S.<br />
F. Ali 1 and Y. Itzhak 2 . 1 Division <strong>of</strong> Neurotoxicology,<br />
NCTR/FDA, Jefferson, AR and 2 Department <strong>of</strong><br />
Psychiatry and Behavioral Sciences, University <strong>of</strong><br />
Miami School <strong>of</strong> Medicine, Miami, FL.<br />
THURSDAY<br />
Environmental neurotoxic chemical exposures are increasingly recognized as<br />
dominant risk factors in the etiology <strong>of</strong> many neurodegenerative disorders<br />
including Parkinson’s disease, Alzheimer’s disease Amyotrophic Lateral<br />
Sclerosis and Huntington’s disease. Exposure to environmental neurotoxic<br />
agents (metals, pesticides, PCBs and others) is <strong>of</strong>ten superimposed with the<br />
pathological hallmarks <strong>of</strong> neurodegenerative disorders. In recent years, cell<br />
death mechanisms have been investigated extensively. Despite this growing<br />
amount <strong>of</strong> information regarding the cell death process, little effort has been<br />
made to integrate this body <strong>of</strong> knowledge with the area <strong>of</strong> neurotoxicology and<br />
establish its relevance to neurodegenerative diseases. This workshop is designed<br />
to fill this gap by entertaining discussion <strong>of</strong> key cell death signaling molecules<br />
and other cellular targets during neurotoxic chemical exposures that may impact<br />
the disease process <strong>of</strong> neurodegenerative disorders. Specifically, novel findings<br />
obtained from both in vitro and in vivo models <strong>of</strong> neurotoxicity using state-<strong>of</strong>the-art<br />
approaches including toxicogenomics, transgenics, knock-outs, and<br />
RNA interference (RNAi) will be presented at this workshop. The workshop<br />
presentations are expected to uncover unifying concepts and set the groundwork<br />
for translation <strong>of</strong> key analogies between neurotoxicology research and neurodegenerative<br />
disorders. Also, questions provided by the speakers will serve as<br />
catalysts for discussion with the audience. Overall, this workshop is likely to<br />
accelerate understanding <strong>of</strong> the role <strong>of</strong> environmental neurotoxic agents in the<br />
etiopathogenesis <strong>of</strong> neurodegenerative disorders as well as to foster the development<br />
<strong>of</strong> novel therapeutic strategies.<br />
202<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
Room RO6<br />
WORKSHOP SESSION: SAFETY ASSESSMENT OF BIOLOGICAL<br />
THERAPEUTIC PRODUCTS- DEFINING THE SCIENTIFIC AND<br />
REGULATORY ISSUES<br />
Chairperson(s): Andrea Weir, U.S. FDA, Rockville, MD and Barbara Mounho,<br />
Amgen, Inc., Thousand Oaks, CA.<br />
Endorsed by:<br />
Immunotoxicology SS<br />
Regulatory and Safety Evaluation SS*<br />
Risk Assessment SS<br />
Toxicologic and Exploratory Pathology SS<br />
Women in <strong>Toxicology</strong> SS<br />
Biological therapeutic products (BTPs) are proteins derived from living organisms<br />
or produced via biotechnology means that have provided the medical<br />
community with novel, highly targeted therapies for the diagnosis and treatment<br />
diseases in humans. An integral part <strong>of</strong> the safety evaluation <strong>of</strong> these products is<br />
toxicology studies. BTP—induced toxicities are typically limited to their pharmacological<br />
mechanism <strong>of</strong> action; therefore, toxicology studies need to be<br />
conducted in an animal model that expresses the receptor or epitope that is recognized<br />
by the product. Frequently, a non-human primate (NHP) is the relevant<br />
model. In recent years, the quality <strong>of</strong> NHPs and the availability <strong>of</strong> methods for<br />
assessing toxicity in these animals have increased. In spite <strong>of</strong> these advances,<br />
many challenges remain in the safety assessment <strong>of</strong> BTPs. For example, only a<br />
very limited toxicological assessment can be conducted if the only relevant<br />
model is a chimpanzee. In such cases, toxicologists use innovative approaches,<br />
including the development <strong>of</strong> surrogate molecules, to conduct toxicology studies.<br />
Therefore, identification <strong>of</strong> novel methods is an ongoing effort in the BTP arena.<br />
Regardless <strong>of</strong> the animal model used, the potential for animals to mount an<br />
immune response to BTPs (immunogenicity) exists. Because immunogenicity<br />
can confound interpretation <strong>of</strong> toxicology studies, it is another challenge facing<br />
toxicologists that can result in the need for innovative approaches to safety<br />
assessment. Additionally, because immunogenicity can occur in humans<br />
receiving BTPs, the development <strong>of</strong> animal models to predict this effect in<br />
humans is an area <strong>of</strong> ongoing research. The need for innovative, flexible<br />
approaches when assessing the safety <strong>of</strong> BTPs is reflected in U.S. FDA and international<br />
regulatory documents. The topics covered in this workshop will provide<br />
toxicologists with the most current information on the unique scientific properties<br />
<strong>of</strong> BTPs and with state—<strong>of</strong>—the—art approaches to safety assessment <strong>of</strong><br />
BTPs.<br />
#1990 8:30 SAFETY ASSESSMENT OF BIOLOGICAL<br />
THERAPEUTIC PRODUCTS — DEFINING THE<br />
SCIENTIFIC AND REGULATORY ISSUES. A.<br />
Weir 1 and B. J. Mounho 2 . 1 FDA/CDER, Rockville, MD<br />
and 2 Amgen Inc., Thousand Oaks, CA.<br />
#1991 8:35 DIFFERENCES BETWEEN SMALL<br />
MOLECULES AND BIOLOGICAL<br />
THERAPEUTIC DRUG PRODUCTS. B. Mounho.<br />
<strong>Toxicology</strong>, Amgen, Inc., Thousand Oaks, CA.<br />
#1992 9:05 IMMUNOGENICITY- IMPACT ON<br />
TOXICOLOGY STUDIES AND BEYOND. D.<br />
Wierda and H. Smith. Immunotoxicology, Eli Lilly<br />
Research Laboratories, Greenfield, IN.<br />
#1993 9:35 THE NONHUMAN PRIMATE AS AN ANIMAL<br />
MODEL FOR THE SAFETY EVALUATION OF<br />
BIOLOGICAL THERAPEUTIC PRODUCTS. J.<br />
Kapeghian. Discovery and Development Services,<br />
Charles River Laboratories, Sierra Division, Sparks,<br />
NV.<br />
#1994 10:05 ALTERNATIVE METHODS FOR THE SAFETY<br />
EVALUATION OF BIOLOGICAL THERAPEUTIC<br />
PRODUCTS — SURROGATE ANTIBODIES AND<br />
BEYOND. J. Clarke. BiogenIdec, Cambridge, MA.<br />
#1995 10:35 SAFETY ASSESSMENT OF BIOLOGICAL<br />
PRODUCTS — A REGULATORY PERSPECTIVE.<br />
H. Ghantous. FDA/CDER/ODEVI/DTBIMP, Rockville,<br />
MD.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: ALTERNATIVES TO MAMMALIAN MODELS<br />
Chairperson(s): Irvin Schultz, Battelle Pacific Northwest Laboratories,<br />
Sequim, WA and George DeGeorge, MB Research Laboratories, Spinnerstown,<br />
PA.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM–10:00 AM<br />
#1996 NOVEL REPORTER GENE ASSAY FOR<br />
DEVELOPMENTAL TOXICITY TESTING. S.<br />
Schwengberg 1 , A. Ehlich 1 , H. Marquardt 2 , J. Hescheler 3<br />
and H. Bohlen 1 . 1 Axiogenesis AG, Cologne, Germany,<br />
2 <strong>Toxicology</strong>, University Hospital, Hamburg, Germany<br />
and 3 Neurophysiology, University Hospital, Cologne,<br />
Germany.<br />
#1997 VALIDATION STATUS OF THE HENS EGG<br />
TEST-CHORIOALLANTOIC MEMBRANE (HET-<br />
CAM) TEST METHOD. N. Choksi 1,2 , D. Allen 1,2 , C.<br />
Inh<strong>of</strong> 1,2 , J. Truax 1,2 , R. Tice 1,2 and W. Stokes 1 .<br />
1 NICEATM, NIEHS, Research Triangle Park, NC and<br />
2 ILS, Inc., Research Triangle Park, NC.<br />
#1998 GENE EXPRESSION SIGNATURES FOR<br />
CADMIUM, MERCURY, AND ACRYLAMIDE<br />
EXPOSURE IN CAENORHABDITIS ELEGANS. D.<br />
Jackson 1 , M. Szilagyi 2 , E. Gehman 2 and E. Clegg 1 . 1 US<br />
Army Center for Environmental Health Research, Fort<br />
Detrick, MD and 2 Geo-Centers, Inc., Fort Detrick, MD.<br />
#1999 CYTOKINE SECRETION PROFILES OF MOUSE<br />
DENDRITIC CELLS : IMPACT OF CELL<br />
TRAUMA. G. Beckwith 1 , C. J. Betts 1 , C. A. Ryan 2 , F.<br />
Gerberick 2 , R. J. Dearman 1 and I. Kimber 1 . 1 Syngenta<br />
CTL, Macclesfield, United Kingdom and 2 Procter &<br />
Gamble, Cincinnati, OH.<br />
#2000 MATRIX METALLOPROTEINASES AS<br />
BIOMARKERS FOR DIOXIN EXPOSURE IN<br />
DEVELOPING JAPANESE MEDAKA (ORYZIAS<br />
LATIPES). V. L. Prince, V. LaPrete, C. M. Villano and<br />
L. A. White. Biochemistry and Microbiology, Rutgers<br />
University, New Brunswick, NJ.<br />
#2001 EPIOCULAR HUMAN CELL CONSTRUCT:<br />
TISSUE VIABILITY AND HISTOLOGICAL<br />
CHANGES FOLLOWING EXPOSURE TO<br />
SURFACTANTS. M. E. Blazka 1 , M. Diaco 2 , J. W.<br />
Harbell 2 , H. Raabe 2 , A. Sizemore 2 , N. Wilt 2 and D. M.<br />
Bagley 1 . 1 Colgate-Palmolive Co., Piscataway, NJ and<br />
2 Institute for In Vitro Sciences, Inc., Gaithersburg, MD.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 203
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2010 #2002 LONG TERM REPRODUCIBILITY OF<br />
Kingdom, 3 Skinethic Laboratories, Nice, France and<br />
4 Ghent University, Ghent, Belgium.<br />
EPIOCULAR TM , A THREE-DIMENSIONAL<br />
TISSUE CULTURE MODEL OF THE HUMAN<br />
CORNEAL EPITHELIUM. M. Klausner, J. E.<br />
Sheasgreen, J. Kubilus and P. J. Hayden. MatTek<br />
Corporation, Ashland, MA.<br />
MELANOCYTE CONTAINING HUMAN<br />
ORGANOTYPIC EPIDERMIS AS A MODEL TO<br />
EVALUATE TOXICITY OF MELANIN BINDING<br />
SUBSTANCES. F. Straube 1 , U. Junker 2 , S. Kretz 1 and<br />
A. Wolf 1 . 1 Biomarker Development, Novartis<br />
Pharmacology, Basel, Switzerland and 2 Preclinical<br />
#2003 HIGH-THROUGHPUT IN VITRO MODELS OF<br />
Safety, Novartis Pharmacology, Basel, Switzerland.<br />
HUMAN EPIDERMIS AND OCULAR<br />
EPITHELIUM FOR PRECLINICAL SAFETY AND<br />
EFFICACY TESTING OF CONSUMER<br />
PRODUCTS AND PHARMACEUTICALS. G. R.<br />
Jackson, J. Kubilus, M. Klausner, J. E. Sheasgreen and<br />
P. J. Hayden. MatTek Corp., Ashland, MA.<br />
#2011 VALIDATION OF A FLOW CYTOMETRY-BASED<br />
PHOTO-LOCAL LYMPH NODE ASSAY (PHOTO-<br />
LLNA) FOR THE IDENTIFICATION AND<br />
CHARACTERIZATION OF PHOTO-<br />
ALLERGENS. M. K. Reeder, T. L. Ripper, D. R.<br />
Cerven and G. L. DeGeorge. MB Research<br />
#2004 EVALUATION OF A TISSUE ENGINEERED<br />
Laboratories, Spinnerstown, PA.<br />
HUMAN SKIN EPIDERM 3-D CULTURE AS A<br />
MODEL TO STUDY IRRITATION AFTER JET<br />
FUEL EXPOSURE. A. Chatterjee, R. Babu and M.<br />
Singh. Florida A&M University, Tallahassee, FL.<br />
#2012 COMPARISON OF ALTERNATIVE TOXICITY<br />
TEST METHODS FOR OCULAR IRRITATION<br />
USING THE AVIAN CHORIOALLANTOIC<br />
MEMBRANE: HET-CAM VS. CAMVA. A. C.<br />
#2005<br />
Gilotti, D. R. Cerven, S. Craig and G. L. DeGeorge. MB<br />
VALIDATION STATUS OF THE BOVINE<br />
Research Laboratories, Spinnerstown, PA.<br />
CORNEAL OPACITY AND PERMEABILITY<br />
(BCOP) TEST METHOD. C. Inh<strong>of</strong> 1,2 , N. Choksi 1,2 , D. #2013 EXPOSURE OF MUCOCILIARY HUMAN LUNG<br />
Allen 1,2 , J. Truax 1,2 , R. Tice 1,2 and W. Stokes 1 .<br />
EPITHELIAL CULTURES TO WHOLE<br />
1 NICEATM, NIEHS, Research Triangle Park, NC and<br />
CIGARETTE SMOKE. A. Richter, J. Phillips, N.<br />
2 ILS, Inc., Research Triangle Park, NC.<br />
Newland and E. D. Massey. R&D, British American<br />
#2006<br />
Tobacco, Southampton, United Kingdom. Sponsor: J.<br />
ASSESSMENT OF THE SKINETHIC<br />
Seagrave.<br />
RECONSTITUTED HUMAN EPIDERMAL<br />
MODEL FOR THE PREDICTION OF THE<br />
DERMAL IRRITATION POTENTIAL OF<br />
PHARMACEUTICAL PROCESS MATERIALS. C.<br />
W. Seaman 1 , R. L. Guest 2 , A. Whittingham 2 , B. De<br />
#2014 USE OF PLATEABLE CRYOPRESERVED RAT<br />
HEPATOCYTES AS A MODEL TO ASSESS<br />
HEPATOTOXICITY AND DRUG-DRUG<br />
INTERACTIONS. T. A. Moeller, S. Lloyd, P. M.<br />
Wever 3 , M. Cappadoro 3 , B. Bertino 3 and E. Adriaens 4 .<br />
Silber and N. S. Jensen. In Vitro Technologies,<br />
1 2 GlaxoSmithKline, Ware, United Kingdom, SafePharm<br />
Baltimore, MD.<br />
Laboratories, Derby, United Kingdom, 3 SkinEthic<br />
Laboratories, Nice, France and 4 University <strong>of</strong> Ghent, #2015 THE SLUG MUCOSAL IRRITATION TEST: A<br />
Ghent, Belgium.<br />
USEFUL TOOL FOR EVALUATING THE LOCAL<br />
TOLERANCE OF PHARMACEUTICAL<br />
#2007 VALIDATION STATUS OF THE ISOLATED<br />
CHICKEN EYE (ICE) TEST METHOD. D. Allen 1,2 ,<br />
N. Choksi 1,2 , C. Inh<strong>of</strong> 1,2 , J. Truax 1,2 , R. Tice 1,2 and W.<br />
FORMULATIONS. E. Adriaens, M. Dhondt and J.<br />
Remon. Lab. Pharmaceutical Technology, Ghent<br />
University, Gent, Belgium. Sponsor: C. Seaman.<br />
Stokes 1 . 1 NICEATM, NIEHS, Research Triangle Park,<br />
NC and 2 ILS, Inc., Research Triangle Park, NC.<br />
#2016 ESTABLISHING THE TOXICOLOGY OF<br />
SELENIUM IN THE MODEL ORGANISM,<br />
#2008 VALIDATION STATUS OF THE ISOLATED<br />
RABBIT EYE (IRE) TEST METHOD. J. Truax 1,2 , N.<br />
Choksi 1,2 , C. Inh<strong>of</strong> 1,2 , D. Allen 1,2 , R. Tice 1,2 and W.<br />
CAENORHABDITIS ELEGANS. M. A. Nascarella<br />
and S. M. Presley. Department <strong>of</strong> Environmental<br />
<strong>Toxicology</strong>, Texas Tech University, Lubbock, TX.<br />
Stokes 1 . 1 NICEATM, NIEHS, Research Triangle Park,<br />
NC and 2 ILS, Inc., Research Triangle Park, NC.<br />
#2017 PROTEOMIC INDICATORS OF PESTICIDE<br />
TOXICITY IN A CAENORHABDITIS ELEGANS<br />
#2009 ASSESSMENT OF THE SKINETHIC<br />
RECONSTITUTED HUMAN CORNEAL<br />
EPITHELIUM MODEL FOR PREDICTION OF<br />
THE OCULAR IRRITATION POTENTIAL OF<br />
MODEL. J. A. Lewis 1 , W. E. Dennis 1 , M. Szilagyi 1 and<br />
D. A. Jackson 2 . 1 Geo-Centers, Inc., Ft. Detrick, MD and<br />
2 US Army Center for Environmental Health Research,<br />
Ft. Detrick, MD.<br />
PHARMACEUTICAL PROCESS CHEMICALS. R.<br />
L. GUEST 1 , C. SEAMAN 2 , B. DE WEVER 3 , M.<br />
#2018 ZEBRAFISH: A GOOD MODEL FOR<br />
CAPPADORO 3 , B. BERTINO 3 , A. WHITTINGHAM 1 ,<br />
DETECTING OTOTOXICITY. C. Ton and C. Parng.<br />
N. WARREN 1 and E. ADRIAENS 4 . 1 Safepharm<br />
Phylonix Pharmaceuticals, Inc., Cambridge, MA.<br />
Laboratories Ltd.,, Derby, United Kingdom,<br />
Sponsor: D. Monteith.<br />
2 GlaxoSmithKline, Ware, Hertfordshire, United<br />
204<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2019 THE ROLE OF RECOMBINANT ZEBRAFISH<br />
CYP1A IN THE METABOLIC ACTIVATION OF<br />
BENZO(A)PYRENE (BAP) AND IN THE<br />
GENERATION OF REACTIVE OXYGEN<br />
SPECIES. W. Chung, C. L. Miranda, J. Wang, T.<br />
Musafia-Jaknic, W. M. Baird and D. R. Buhler.<br />
Environment & Molec. <strong>Toxicology</strong>, Oregon State<br />
University, Corvallis, OR.<br />
#2020 DEVELOPMENT OF SPECIFIC ANTIPEPTIDE<br />
ANTIBODIES AGAINST ZEBRAFISH<br />
XENOBIOTIC METABOLISING FORMS OF<br />
CYTOCHROME P450. J. Wang-Buhler 1 , W. Chung 1 ,<br />
H. Tseng 2 , C. L. Miranda 1 , C. Hu 2 , T. Hseu 3 and D. R.<br />
Buhler 1 . 1 Environment & Molec. <strong>Toxicology</strong>, Oregon<br />
State University, Corvallis, OR, 2 Institute <strong>of</strong> Marine<br />
Biotechnology, National Taiwan Ocean University,<br />
Keelung, Taiwan and 3 Department <strong>of</strong> Life Science,<br />
National Tsing-Hua University, Hsinchu, Taiwan.<br />
#2021 ORAL ABSORPTION OF WATER SOLUBLE AND<br />
LIPOPHILIC CONTAMINANTS IN THE<br />
JAPANESE MEDAKA. I. Schultz, E. Muirhead, S.<br />
Reed and A. Pratt. Battelle PND, Sequim, WA.<br />
#2022 INTERACTION TRAPPING WITH A NON-TCDD<br />
BINDING ARYL HYDROCARBON RECEPTOR<br />
FROM MYA ARENARIA. R. Butler and R. J. Van<br />
Beneden. University <strong>of</strong> Maine, Orono, ME.<br />
#2023 GENOMICS RESPONSES AND<br />
TOXICOLOGICAL ENDPOINTS AMONG FISH<br />
SPECIES EXPOSED TO ESTROGEN AND<br />
POTENTIAL EXTRAPOLATION OF FISH<br />
TOXICITY ASSAYS TO MAMMALIAN SPECIES.<br />
P. Cline 1 , N. Denslow 2 and P. Larkin 3 . 1 CH2M Hill,<br />
Gainesville, FL, 2 University <strong>of</strong> Florida, Gainsville, FL<br />
and 3 EcoArray, Inc., Alachua, FL.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: SAFETY EVALUATION-SAFETY<br />
PHARMACOLOGY<br />
Chairperson(s): Catherine Kelly, Huntingdon Life Sciences, East Millston,<br />
NJ.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 10:00 AM–11:30 AM<br />
#2024 THE USE OF A ROTAROD IN CNS SAFETY<br />
PHARMACOLOGY STUDIES – A COMPARISON<br />
OF TRAINING AND TESTING METHODS. H.<br />
Penton and S. Mason. Safety Pharmacology, CTBR<br />
BioResearch Inc., Senneville, QC, Canada. Sponsor: C.<br />
Banks.<br />
#2025 EVALUATION OF AN INTEGRATED<br />
TELEMETRY SYSTEM (ITS) FOR<br />
MEASUREMENT OF CARDIOVASCULAR AND<br />
RESPIRATORY PARAMETERS IN<br />
CYNOMOLGUS MONKEYS. M. Nieh<strong>of</strong>f, P. Nowak,<br />
U. Zuehlke, W. Mueller, F. Vogel and G. Weinbauer.<br />
Covance Laboratories GmbH, 48163 Muenster,<br />
Germany.<br />
#2026 VALIDATION OF SAFETY PHARMACOLOGY<br />
ASSESSMENT OF CARDIOVASCULAR<br />
FUNCTION IN CONSCIOUS DOGS WITH TWO<br />
POSITIVE CONTROLS (SOTALOL AND<br />
IBUTILIDE). Y. Chen, M. Lindeblad and A. Lyubimov.<br />
<strong>Toxicology</strong> Research Laboratory, University <strong>of</strong> Illinois<br />
at Chicago, Chicago, IL.<br />
#2027 INTEGRATED ASSESSMENT OF SMALL<br />
MOLECULE INTERACTION WITH THE HERG<br />
CHANNEL: WHAT DOES THE HERG BINDING<br />
ASSAY MISS? C. M. Doherty, V. Sasseville, P.<br />
Bouchard, C. L. Alden, P. F. Smith and V. J. Kadambi.<br />
Drug Safety and Disposition, Millennium<br />
Pharmaceuticals, Inc., Cambridge, MA.<br />
#2028 MEASUREMENT OF CARDIOVASCULAR<br />
EFFECTS OF PHARMACEUTICALS IN<br />
MINIPIGS USING TELEMETRY. A. Makin, H.<br />
Saxtorph and R. J. Harling. <strong>Toxicology</strong> and<br />
Pharmacology, Scantox A/S, Lille Skensved, Denmark.<br />
#2029 VALIDATION OF A RADIOTELEMETRIC<br />
SYSTEM FOR THE MEASUREMENT OF<br />
CARDIOVASCULAR PARAMETERS AND<br />
TEMPERATURE IN THE CONSCIOUS<br />
CYNOMOLGUS MONKEY. J. L. Fogleman and C.<br />
B. Spainhour. Calvert Laboratories, Inc., Olyphant, PA.<br />
#2030 A REVIEW OF THE RELATIONSHIP BETWEEN<br />
HEART RATE AND QT INTERVAL IN THE<br />
BEAGLE DOG. J. Budnik 1 and B. N. Olivier 2 .<br />
1 <strong>Toxicology</strong>, CTBR, Senneville, QC, Canada and<br />
2 Michigan State University, East Lansing, MI.<br />
#2031 DEVELOPMENT OF THE METHODOLOGY FOR<br />
RESPIRATORY RATE AND VOLUME<br />
ASSESSMENT USING LINEAR PNEUMATACHS<br />
AND BUXCO BIOSYSTEM XA SYSTEM IN THE<br />
CONSCIOUS DOG AND CYNOMOLGUS<br />
MONKEY. C. M. Kelly, M. Miyamoto, S. Cracknell<br />
and S. J. Gosselin. Safety Assessment, Huntingdon Life<br />
Sciences, East Millstone, NJ.<br />
#2032 USE OF GAMMA SCINTIGRAPHY FOR THE<br />
STUDY OF GASTRIC EMPTYING IN SAFETY<br />
PHARMACOLOGY. X. Manciaux 1 , S. Milano 1 , H.<br />
Barraud 1 , V. Roger 1 , S. Lerondel 2 , A. Lepape 2 and J.<br />
Descotes 3 . 1 MDS Pharmacology Services, Saint<br />
Germain s/L’Arbresle, France, 2 Functional Imaging <strong>of</strong><br />
Transgenic Mice, CDTA-CNRS, Orleans, France and<br />
3 Poison Center, Lyon, France.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 205
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: PERSISTENT ORGANIC POLLUTANTS<br />
Chairperson(s): Jay Silkworth, General Electric Company, Schenectady, NY.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM–10:00 AM<br />
#2033 EFFECTS OF TCDD ON THE LEVELS OF<br />
BIOGENIC AMINES IN DIFFERENT BRAIN<br />
REGIONS OF RATS AFTER SUBCHRONIC<br />
EXPOSURE. K. Masters, J. Byers and E. A. Hassoun.<br />
Pharmacology, The University <strong>of</strong> Toledo, Toledo, OH.<br />
#2034 IGF-1 MEDIATES THE EFFECTS OF TCDD AND<br />
HXCDD ON BODY WEIGHT AND THE<br />
INHIBITION OF PEPCK. C. R. Croutch 1 , M.<br />
Leb<strong>of</strong>sky 1 , P. F. Terranova 2 and K. K. Rozman 1,3 .<br />
1 Pharmacology <strong>Toxicology</strong> and Ther, University <strong>of</strong> KS<br />
Med. Center, Kansas City, KS, 2 Center for Reprod.<br />
Sciences. and Mol. and Integrative Phys., University <strong>of</strong><br />
KS Med. Center, Kansas City, KS and 3 Environment<br />
<strong>Toxicology</strong>, GSF-Institut fur Toxikologie, Neuherberg,<br />
Germany.<br />
#2035 COMPARATIVE 14-WEEK TOXICITY STUDIES<br />
OF 2, 3, 7, 8-TETRACHLORODIBENZO-P-<br />
DIOXIN (TCDD) IN FEMALE HARLAN<br />
SPRAGUE-DAWLEY (HSD) AND FISCHER 344<br />
(F344) RATS. M. Hejtmancik 1 , L. Fomby 1 , D.<br />
Vasconcelos 1 , M. Ryan 1 , M. Vallant 2 , D. Orzech 2 , R.<br />
Chhabra 2 , A. Nyska 2 , H. Toyoshiba 2 , N. Walker 2 and M.<br />
Hooth 2 . 1 Battelle Columbus, Columbus, OH and 2 ETP,<br />
NIEHS, Research Triangle Park, NC.<br />
#2036 EFFECTS OF 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN (TCDD)<br />
ON PROLACTIN (PRL) GENE EXPRESSION IN<br />
VIVO AND IN VITRO. J. Cao and S. L. Petersen.<br />
Molecular and Cellular Biology <strong>Program</strong>, Amherst,<br />
MA.<br />
#2037 INVOLVEMENT OF PROSTAGLANDIN<br />
PATHWAY IN CIRCULATION FAILURE<br />
INDUCED BY 2, 3, 7, 8-<br />
TETRACHLORODIBENZO-P-DIOXIN IN<br />
DEVELOPING ZEBRAFISH. H. Teraoka 1 , W.<br />
Dong 1,2 , A. Shindo 1 , Y. Harada 3 and T. Hiraga 1 . 1 School<br />
<strong>of</strong> Veterinary Medicine, Rakuno Gakuen University,<br />
Ebetsu, Japan, 2 College <strong>of</strong> Animal science and<br />
Technology, Inner Mongolia University for<br />
Nationalities, TongLiao, China and 3 Graduate School <strong>of</strong><br />
Medical Science, Kitasato University, Sagamihara,<br />
Japan.<br />
#2038 DOSE- AND TIME-DEPENDENT HEPATIC GENE<br />
EXPRESSION PROFILING IN FEMALE RATS<br />
EXPOSED TO PCB126. R. J. Foxenberg 1 , B. J.<br />
Ovando 1 , K. M. Kransler 1 , C. M. Vezina 2 and J. R.<br />
Olson 1 . 1 Pharmacology and <strong>Toxicology</strong>, SUNY at<br />
Buffalo, Buffalo, NY and 2 Pharmacy, University <strong>of</strong><br />
Wisconsin, Madison, WI.<br />
#2039 EFFECTS OF AMMONIUM PERCHLORATE ON<br />
LIVER ENZYMES AND THE THYROID AXIS OF<br />
RATS PRETREATED WITH PCB126. E. D.<br />
McLanahan 1 , J. Campbell 1 , S. Muralidhara 1 , J. Hedge 2 ,<br />
L. Narayanan 3 , J. Bruckner 1 , K. Cr<strong>of</strong>ton 2 , D. Mattie 3 ,<br />
D. Keys 1 , M. Mumtaz 4 , D. Ferguson 1 and J. Fisher 1 .<br />
1 Interdisciplinary <strong>Toxicology</strong> <strong>Program</strong>, University <strong>of</strong><br />
Georgia, Athens, GA, 2 Neurotoxicology Division, U.S.<br />
EPA/ORD/NHEERL, Research Triangle Park, NC,<br />
3 AFRL/HEPB, Wright-Patterson AFB, OH and<br />
4 Division <strong>of</strong> <strong>Toxicology</strong>, ATSDR, Atlanta, GA.<br />
#2040 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN<br />
MODULATES A TRANSLOCATION OF PKC-βII<br />
VIA RECEPTOR FOR ACTIVATED C KINASE<br />
(RACK-1) IN DEVELOPING NEURONAL CELLS<br />
IN CULTURE. J. Yang. Pharmacology/<strong>Toxicology</strong>,<br />
Catholic University <strong>of</strong> Daegu, Daegu, South Korea.<br />
Sponsor: P. Kodavanti.<br />
#2041 TCDD ELICITS TYPICAL DEFENSIVE CELL<br />
STRESS RESPONSES FROM MCF10A CELLS: A<br />
STUDY ON THE MECHANISM OF ITS CELL<br />
RESCUING ACTION FROM UV-INDUCED<br />
APOPTOSIS. F. Matsumura and S. Park. Center for<br />
Health and the Environment, University <strong>of</strong> California,<br />
Davis, Davis, CA.<br />
#2042 SELECTIVE MODIFICATION OF BHLH/PAS<br />
GENE EXPRESSION BY TCDD IN RAT<br />
HYPOTHALAMUS. J. Linden 1 , M. Korkalainen 2 , J.<br />
Tuomisto 2 and R. Pohjanvirta 1,3,2 . 1 Department <strong>of</strong> Food<br />
and Environmental Hygiene, University <strong>of</strong> Helsinki,<br />
Helsinki, Finland, 2 Department <strong>of</strong> Environmental<br />
Health, National Public Health Institute, Kuopio,<br />
Finland and 3 Kuopio Department, National Veterinary<br />
and Food Research Institute, Kuopio, Finland.<br />
#2043 COMPARISON OF THE TCDD-INDUCED<br />
CYP1A1 GENE EXPRESSION PROFILE IN<br />
LYMPHOCYTES FROM MICE, RATS AND<br />
HUMANS. K. Nohara, Y. Miyamoto, K. Ao, T. Ito and<br />
C. Tohyama. National Institute for Environmental<br />
Studies, Tsukuba, Japan.<br />
#2044 ANALYSIS OF TEQ-EQUIVALENT AROCLOR<br />
AND TCDD TREATED RATS REVEALS<br />
DIFFERENT GENE DOSE-RESPONSE PROFILES<br />
AMONG DIOXIN RESPONSIVE GENES. K.<br />
Illouz 1 , S. Goodwin 3 , A. Possolo 1 , S. B. Hamilton 2 , T.<br />
R. Sutter 3 and J. B. Silkworth 1 . 1 GE Global Research,<br />
Schenectady, NY, 2 GE Corporate, Fairfield, CT and<br />
3 Feinstone Center for Genomic Research, U Memphis,<br />
Memphis, TN.<br />
#2045 DIOXIN-RESPONSIVE DOWN-REGULATION OF<br />
SERPINA7, CYP3A9/3A13, AND CES3 REQUIRES<br />
A FUNCTIONAL ARYL HYDROCARBON<br />
RECEPTOR. B. J. Ovando 1 , C. M. Vezina 2 and J. R.<br />
Olson 1 . 1 Pharmacology & <strong>Toxicology</strong>, University at<br />
Buffalo, Buffalo, NY and 2 Pharmacy, Unviversity <strong>of</strong><br />
Wisconsin, Madison, WI.<br />
206<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2046 COPLANAR POLYCHLORINATED BIPHENYLS<br />
ACTIVATE ARYL HYDROCARBON RECEPTOR<br />
IN DEVELOPING TISSUES OF TWO TCDD-<br />
RESPONSIVE LACZ MOUSE LINES. J. C. Bemis 1 ,<br />
D. A. Nazarenko 2 and T. A. Gasiewicz 1 . 1 Environmental<br />
Medicine, University <strong>of</strong> Rochester, Rochester, NY and<br />
2 <strong>Toxicology</strong> and Applied Biology, Alkemes Inc.,<br />
Cambridge, MA.<br />
#2047 CCN4 AND CCN5 ARE DOWN REGULATED IN<br />
RESPONSE TO THE ADIPOGENIC<br />
STIMULATION WHILE 2, 3, 7,<br />
8–TETRACHLORODIBENZO-P-DIOXIN (TCDD)<br />
ELEVATES CCN5 MESSAGE IN C3H10T1/2<br />
MOUSE EMBRYO FIBROBLASTS. M. Cimafranca<br />
and C. Jefcoate. Pharmacology, University <strong>of</strong><br />
Wisconsin, Madison, WI.<br />
#2048 DEVELOPMENT OF A NEW DIOXIN-<br />
ANALOGUE: 2, 3, 7, 8-<br />
TETRACHLOROPHENOTHIAZINE. K. W.<br />
Fried 1,2 , G. I. Georg 3 , P. F. Terranova 4,5,6 and K. K.<br />
Rozman 1,7 . 1 Pharmacology, <strong>Toxicology</strong> & Therapeutics,<br />
The University <strong>of</strong> Kansas Medical Center (KUMC),<br />
Kansas City, KS, 2 Institute <strong>of</strong> Ecological Chemistry,<br />
GSF-National Research Center for Environment &<br />
Health, Neuherberg, Germany, 3 Medicinal Chemistry,<br />
The University <strong>of</strong> Kansas, Lawrence, KS, 4 Center for<br />
Reproductive Sciences, KUMC, Kansas City, KS,<br />
5 Molecular & Integrative Physiology, KUMC, Kansas<br />
City, KS, 6 Obstetrics & Gynecology, KUMC, Kansas<br />
City, KS and 7 Institute <strong>of</strong> <strong>Toxicology</strong>, GSF, Neuherberg,<br />
Germany.<br />
#2049 COMPARISON OF GC/MS AND CALUX ® BY<br />
XDS FOR DETECTION OF DIOXIN LIKE<br />
COMPOUNDS IN ENVIRONMENTAL SAMPLES.<br />
G. C. Clark 1 , A. C. Chu 1 , J. D. Gordon 1 , M. D. Chu 2<br />
and M. S. Denison 3 . 1 Xenobiotic Detection Systems,<br />
Inc., Durham, NC, 2 Alta Analytical Perspectives,<br />
Wilmington, NC and 3 Department <strong>of</strong> Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> California, Davis, Davis, CA.<br />
#2050 INDUCTION OF EROD-ACTIVITY IN VITRO BY<br />
2, 3, 7, 8-TETRACHLOROPHENOTHIAZINE. K.<br />
W. Fried 1,2 , N. Chahbane 2 , C. Corsten 2 , K. Schramm 2 ,<br />
A. Kettrup 2 and K. K. Rozman 3 . 1 Department <strong>of</strong><br />
Pharmacology, <strong>Toxicology</strong> & Therapeutics, The<br />
University <strong>of</strong> Kansas Medical Center, Kansas City, KS,<br />
2 Institute <strong>of</strong> Ecological Chemistry, GSF-National<br />
Research Center for Environment & Health,<br />
Neuherberg, Germany and 3 Institute <strong>of</strong> <strong>Toxicology</strong>,<br />
GSF, Neuherberg, Germany.<br />
#2051 LYMPHOCYTES CHOLINERGIC MUSCARINIC<br />
RECEPTORS: IN VIVO AND IN VITRO EFFECTS<br />
OF THE COMBINED EXPOSURE TO<br />
POLYCHLORINATED BIPHENYLS AND<br />
METHYLMERCURY. L. Manzo 1,2 , A. F. Castoldi 2 , G.<br />
Randine 2 and T. Coccini 2 . 1 <strong>Toxicology</strong> Division,<br />
University <strong>of</strong> Pavia, Pavia, Italy and 2 IRCCS Maugeri<br />
Foundation, Pavia, Italy.<br />
#2052 THE ROLE OF SUPEROXIDE ANION IN 2, 2′, 4,<br />
4′-TETRACHLOROBIPHENYL-INDUCED<br />
UPREGULATION OF COX-2 IN HL-60 CELLS. S.<br />
Bezdecny 1,2,3 , R. A. Roth 1,2,3 and P. E. Ganey 1,2,3 .<br />
1 Department <strong>of</strong> Pharmacology and <strong>Toxicology</strong>,<br />
Michigan State University, Lansing, MI, 2 Center for<br />
Integrative <strong>Toxicology</strong>, Michigan State University, East<br />
Lansing, MI and 3 National Food safety and <strong>Toxicology</strong><br />
Center, Michigan State University, East Lansing, MI.<br />
#2053 RYR1 MALIGNANT HYPERTHERMIA POINT<br />
MUTATION R615C ENHANCES<br />
SUSCEPTIBILITY TO NON-COPLANAR 2, 2’, 3,<br />
5’-PENTACHLOROBIPHENYL (PCB 95). T. N. Ta 1 ,<br />
B. R. Fruen 2 and I. N. Pessah 1 . 1 VM: Molecular<br />
Biosciences, UC Davis, Davis, CA and 2 Department <strong>of</strong><br />
Biochemistry, Molecular Biology, and Biophysics,<br />
Minnesota.<br />
#2054 ANALYSIS OF THE TUMOR PROMOTING<br />
POTENCY OF PCB 28 AND PCB 101 IN RAT<br />
LIVER. S. Kunz 1 , H. Schmitz 1 , M. Schwarz 2 , B.<br />
Schilling 3 , O. Paepke 3 , H. Lehmler 4 , L. Robertson 4 and<br />
D. Schrenk 1 . 1 Food Chemistry and Environmental<br />
<strong>Toxicology</strong>, University <strong>of</strong> Kaiserslautern,<br />
Kaiserslautern, Germany, 2 Department <strong>of</strong> <strong>Toxicology</strong>,<br />
University <strong>of</strong> Tuebingen, Tuebingen, Germany, 3 ERGO<br />
Research, Hamburg, Germany and 4 Department <strong>of</strong><br />
Occupational and Environmental Health, University <strong>of</strong><br />
Iowa, Iowa City, IA.<br />
#2055 TRANSCRIPTIONAL PROFILING OF RAT<br />
HEPATIC RESPONSES TO DIETARY EXPOSURE<br />
TO AROCLOR 1254. T. M. Basford 1,2 and J. C.<br />
Means 1,2 . 1 Chemistry, Western Michigan University,<br />
Kalamazoo, MI and 2 Great Lakes Environmental and<br />
Molecular Science Center, Kalamazoo, MI.<br />
#2056 COMPARISON OF AROCLOR AND TCDD<br />
RESPONSIVE GENES BETWEEN IN VIVO AND<br />
IN VITRO EXPOSURES USING DNA<br />
MICROARRAYS. M. Zhao 1 , S. Arunajadai 2 , K.<br />
Illouz 1 , A. Possolo 1 , A. Koganti 3 , S. B. Hamilton 4 , S.<br />
Goodwin 5 , T. R. Sutter 5 and J. B. Silkworth 1 . 1 Global<br />
Research, GE, Schenectady, NY, 2 U.C Berkeley,<br />
Berkeley, CA, 3 In Vitro Technologies, Baltimore, MD,<br />
4 5 GE Corporate, Fairfield, CT and U Memphis,<br />
Memphis, TN.<br />
#2057 ACCUMULATION OF PBDE-47 IN PRIMARY<br />
CULTURES OF RAT NEOCORTICAL CELLS. W.<br />
Mundy 1 , T. M. Freudenrich 1 , K. M. Cr<strong>of</strong>ton 1 and M. J.<br />
DeVito 2 . 1 Neurotoxicolgy Division, U.S. EPA, Research<br />
Triangle Park, NC and 2 Experimental <strong>Toxicology</strong><br />
Division, U.S. EPA, Research Triangle Park, NC.<br />
#2058 MIXTURE EFFECTS OF PCBs AND PBDES<br />
WITH OTHER CONTAMINANTS/DRUGS. H. L.<br />
Esch, L. W. Robertson and G. Ludewig. Department <strong>of</strong><br />
Occupational & Environmental Health, University <strong>of</strong><br />
Iowa, Iowa City, IA.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 207
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2066 MEASUREMENT OF THYROID HORMONES IN<br />
#2059 EFFECT OF PBDES ON TCDD-INDUCED<br />
2 NERL, U.S. EPA, Athens, GA.<br />
CYP1A1 ACTIVITY (EROD) IN PRIMARY<br />
HEPATOCYTES OF CYNOMOLGUS MONKEYS.<br />
L. Peters 1 , A. Bergman 2 , J. T. Sanderson 1 and M. van<br />
den Berg 1 . 1 Institute for Risk Assessment Sciences,<br />
University <strong>of</strong> Utrecht, Utrecht, Netherlands and<br />
2 Department <strong>of</strong> Environmental Chemistry, University <strong>of</strong><br />
Stockholm, Stockholm, Sweden.<br />
RAT SERA CONTAINING<br />
PERFLUOROOCTANESULFONATE (PFOS). S.<br />
Tanaka 1 , J. Thibodeaux 2 , M. Eastvold 3 , J. Bjork 4 , D.<br />
Ehresman 1 , R. Singh 3 , K. Wallace 4 , C. Lau 2 and J.<br />
Butenh<strong>of</strong>f 1 . 1 3M Company, St. Paul, MN, 2 U.S. EPA,<br />
Research Triangle Park, NC, 3 Mayo Medical<br />
Laboratories, Rochester, MN and 4 University <strong>of</strong><br />
#2060 2, 2’-DIBROMODIPHENYL ETHER BINDS AND<br />
Minnesota, Duluth, MN.<br />
INDUCES CALCIUM RELEASE THROUGH THE<br />
RYANODINE RECEPTOR IN AN FKBP12-<br />
DEPENDENT MANNER. J. Riehl and I. Pessah.<br />
School <strong>of</strong> Veterinary Medicine: Molecular Biosciences,<br />
University <strong>of</strong> California Davis, Davis, CA.<br />
#2067 PROLONGATION OF K + -INDUCED BACKWARD<br />
SWIMMING OF PARAMECIUM CAUDATUM BY<br />
PFOS AND PFOA. Y. Yamazaki, K. Harada, A.<br />
Morikawa, T. Yoshinaga and A. Koizumi. Health<br />
Environmental Sciences, Kyoto University Graduate<br />
#2061 THE BROMINATED FLAME RETARDANT<br />
School <strong>of</strong> Medicine, Kyoto, Japan.<br />
HBCDD INDUCES CYP2B AND CYP3A BUT NOT<br />
CYP1A IN RAT LIVER. S. Germer 1 , L. van der Ven 2 ,<br />
A. H. Piersma 2 and D. Schrenk 1 . 1 Food Chemistry and<br />
Environmental <strong>Toxicology</strong>, University <strong>of</strong><br />
Kaiserslautern, Kaiserslautern, Germany, 2 Laboratory<br />
for <strong>Toxicology</strong>, Pathology and Genetics, National<br />
Institute for Public Health and the Environment RIVM,<br />
Bilthoven, Netherlands and 3 National Institute for<br />
Public Health and the Environment RIVM, Bilthoven,<br />
#2068 A SIGNIFICANTLY LARGER<br />
BIOCONCENTRATION FACTOR OF PFOS THAN<br />
THAT OF PFOA IN WILD TURTLES: THE AI<br />
RIVER ECOLOGICAL STUDY IN JAPAN. A.<br />
Morikawa 1 , N. Kamei 1 , N. Saito 2 , K. Harada 1 , K.<br />
Inoue 1 , T. Yoshinaga 1 and A. Koizumi 1 . 1 Kyoto<br />
University Graduate School <strong>of</strong> Medicine, Kyoto, Japan<br />
and 2 Research Institute for Environmental Sciences and<br />
Public Health <strong>of</strong> Iwate Prefecture, Morioka, Japan.<br />
Netherlands.<br />
#2069 ANALYTICAL METHOD VALIDATION FOR<br />
#2062 NEONATAL EXPOSURE TO POLYBROMINATED<br />
DIPHENYL ETHERS, PBDE 183, PBDE 203, AND<br />
PBDE 206, CAUSES NEUROTOXIC EFFECTS IN<br />
ADULT MICE. N. Johansson 1 , H. Viberg 1 , J.<br />
QUANTITATION OF 1, 2, 3, 4, 6, 7<br />
HEXACHLORONAPHTHALENE FROM RAT<br />
ADIPOSE TISSUE. P. Schebler 1 , K. Brackman 1 , K.<br />
White 1 , D. Messer 1 , J. Algaier 1 , A. Clark 1 , R. Harris 1 ,<br />
Eriksson 2 , A. Fredriksson 1 and P. Eriksson 1 .<br />
B. Jayaram 2 and C. Smith 2 . 1 Life Sciences Division,<br />
1 Department <strong>of</strong> Environmental <strong>Toxicology</strong>, Uppsala<br />
Midwest Research Institute, Kansas City, MO and<br />
University, Uppsala, Sweden and 2 2<br />
Department <strong>of</strong><br />
Environmental <strong>Toxicology</strong> <strong>Program</strong>, NIEHS, Research<br />
Environmental Chemistry, Stockholm University,<br />
Triangle Park, NC.<br />
Stockholm, Sweden.<br />
#2070 14-WEEK COMPARATIVE STUDY OF 1, 2, 3, 4, 6,<br />
#2063 EFFECT OF PERFLUOROOCTANE SULFONATE<br />
(PFOS) AND PERFLUOROOCTANOATE (PFOA)<br />
ON L-TYPE CALCIUM CURRENT IN GUINEA<br />
PIG VENTRICULAR MYOCYTES. K. Harada 1 , F.<br />
Xu 2 , K. Ono 2 , T. Iijima 2 and A. Koizumi 1 . 1 Health<br />
Environmental Sciences, Kyoto University Graduate<br />
School <strong>of</strong> Medicine, Kyoto, Japan and 2 Pharmacology,<br />
Akita University School <strong>of</strong> Medicine, Akita, Japan.<br />
7-HEXACHLORONAPHTHALENE (PCN 66) AND<br />
1, 2, 3, 5, 6, 7-HEXACHLORONAPHTHALENE<br />
(PCN 67) IN FEMALE HARLAN SPRAGUE-<br />
DAWLEY (HSD) AND FISCHER 344 (F344) RATS.<br />
M. Hooth 1 , M. Vallant 1 , N. Walker 1 , A. Nyska 1 , H.<br />
Toyoshiba 1 , R. Chhabra 1 , M. Ryan 2 , D. Vasconcelos 2 ,<br />
M. Hejtmancik 2 and L. Fomby 2 . 1 ETP, NIEHS, Research<br />
Triangle Park, NC and 2 Battelle Columbus, Columbus,<br />
#2064 RENAL CLEARANCES OF<br />
OH.<br />
PERFLUOROOCTANE SULFONATE AND<br />
PERFLUOROOCTANOATE IN HUMANS, AND<br />
SPECIES-SPECIFIC EXCRETION OF THESE<br />
CHEMICALS. K. Harada 1 , K. Inoue 1 , A. Morikawa 1 ,<br />
T. Yoshinaga 1 , N. Saito 2 , M. Kimura 3 , S. Shimbo 4 and<br />
A. Koizumi 1 . 1 Health Environmental Sciences, Kyoto<br />
University Graduate School <strong>of</strong> Medicine, Kyoto, Japan,<br />
2 Research Institute for Environmental Sciences and<br />
Public Health <strong>of</strong> Iwate Prefecture, Morioka, Japan,<br />
3 Kyoto Prefectural University <strong>of</strong> Medicine, Kyoto,<br />
Japan and 4 Kyoto Women’s University, Kyoto, Japan.<br />
#2071 SOURCES AND DISTRIBUTION OF<br />
POLYCYCLIC AROMATIC HYDROCARBONS IN<br />
NEW ORLEANS AND DETROIT SOILS. G. Wang 1 ,<br />
H. Mielke 2 , Q. Zhang 1 , P. Ma 1 , J. Rowden 1 and C.<br />
Gonzales 2 . 1 Chemistry, Xavier University <strong>of</strong> Louisiana,<br />
New Orleans, LA and 2 College <strong>of</strong> Pharmacy, Xavier<br />
University <strong>of</strong> Louisiana, New Orleans, LA.<br />
#2065 MAMMALIAN METABOLISM AND<br />
DISTRIBUTION OF PERFLUOROOCTYL<br />
ETHANOL AND ITS OXIDATION<br />
METABOLITES. W. M. Henderson 1,2 , E. J. Weber 2 , S.<br />
E. Duirk 2 and M. Smith 1 . 1 Interdisciplinary <strong>Toxicology</strong><br />
<strong>Program</strong>, University <strong>of</strong> Georgia, Athens, GA and<br />
208<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2072 DIOXINS AND DIOXIN LIKE COMPOUNDS<br />
FROM AGENT ORANGE AND OTHER SOURCES<br />
IN VIETNAM FROM THE 1970S TO THE<br />
PRESENT. A. J. Schecter 1 , H. T. Quynh 2 , O. Paepke 3 ,<br />
J. D. Constable 4 , K. C. Tung 1 , R. Malisch 5 and P.<br />
Fuerst 6 . 1 Environmental Sciences, University <strong>of</strong> Texas<br />
School <strong>of</strong> Public Health, Dallas, TX, 2 Center for Cancer<br />
Research, Hanoi, Viet Nam, 3 ERGO Research<br />
Laboratory, Hamburg, Germany, 4 Harvard Medical<br />
School, Boston, MA, 5 State Laboratory for Chemical<br />
and Veterinary Analysis, Freiburg, Germany and<br />
6 Chemical and Veterinary Control Laboratory,<br />
Muenster, Germany.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: RISK ASSESSMENT II<br />
Chairperson(s): Mara Seeley, Gradient Corporation, Cambridge, MA and<br />
Michael Wade, Cal EPA, Sacramento, CA.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 10:00 AM–11:30 AM<br />
#2073 DEVELOPMENT OF FLORIDA-SPECIFIC RISK-<br />
BASED SOIL AND GROUNDWATER CLEANUP<br />
TARGETS FOR VOLATILIZATION OF<br />
CHEMICALS INTO INDOOR AIR. E. M.<br />
Tufariello 1 , C. M. Saranko 1 , R. Ettinger 2 , S. M. Roberts 3<br />
and J. K. Tolson 1 . 1 GEOSYNTEC CONSULTANTS,<br />
Tampa, FL, 2 GEOSYNTEC CONSULTANTS, Santa<br />
Barbara, CA and 3 University <strong>of</strong> Florida, Gainesvile, FL.<br />
#2074 A ROBUST ALGORITHM FOR CALCULATING<br />
OPTIMAL 95 0/00 UPPER CONFIDENCE LIMITS<br />
(95 0/00 UCLS) ON THE MEAN FOR<br />
ENVIRONMENTAL DATASETS. J. K. Tolson 1 , C. J.<br />
Saranko 1 , S. M. Roberts 2 and K. M. Portier 2 .<br />
1 GEOSYNTEC CONSULTANTS, Tampa, FL and<br />
2 University <strong>of</strong> Florida, Gainsville, FL.<br />
#2075 THE EFFECT OF USING MULTIPLE<br />
CONTAMINANT 95 0/00 UCLS ON<br />
CUMMULATIVE RISK ESTIMATES. C. J.<br />
Saranko, E. M. Tufariello and J. K. Tolson.<br />
GEOSYNTEC CONSULTANTS, Tampa, FL.<br />
#2076 EVALUATION OF THE PREDICTIVITY OF A<br />
FISH UPTAKE MODEL FOR MERCURY USING<br />
EMPERICAL DATA. R. P. Brellenthin 1 , J. K. Tolson 1 ,<br />
K. Kessler 2 and C. J. Saranko 1 . 1 Geosyntec<br />
Consultants, Tampa, FL and 2 Geosyntec Consultants,<br />
Atlanta, GA.<br />
#2077 RETROSPECTIVE SCREENING-LEVEL HUMAN<br />
HEALTH RISK ASSESSMENT FOR<br />
RECREATIONAL EXPOSURE TO<br />
CONTAMINATED SEDIMENT. P. Welsh, M.<br />
Pagliarulo and D. A. Manca. Standards Development<br />
Branch, Ontario Ministry <strong>of</strong> the Environment, Toronto,<br />
ON, Canada.<br />
#2078 PROVISIONAL REFERENCE DOSE FOR THE<br />
AROMATIC FRACTION OF JET FUEL:<br />
REASSESSMENT OF FRACTION RISK AND<br />
IMPACT ON RISK BASED CLEANUP LEVELS. T.<br />
R. Sterner 1 , D. J. Vorhees 2 , D. R. Mattie 3 , D. A. Reed 1<br />
and W. H. Weisman 4 . 1 OpTech Corp., Dayton, OH,<br />
2 Menzie-Cura & Assoc., Inc., Winchester, MA,<br />
3 4 AFRL/HEPB, Wright-Patterson AFB, OH and HQ<br />
AF/SGOP, Bolling AFB, DC.<br />
#2079 DESIGNATION OF NAPHTHALENE AS A<br />
CARCINOGEN: RISK ASSESSMENT FOR<br />
INHALATION EXPOSURE PATHWAYS AT<br />
HAZARDOUS WASTE SITES. J. P. Christopher, J.<br />
M. Polisini, B. K. Davis and M. J. Wade. Department <strong>of</strong><br />
Toxic Substances Control, California Environmental<br />
Protection Agency, Sacramento, CA.<br />
#2080 INORGANIC CHEMICALS IN GROUND WATER<br />
AND SOIL: BACKGROUND CONCENTRATIONS<br />
AT CALIFORNIA AIR FORCE BASES. P. M.<br />
Hunter 1 , B. K. Davis 2 and F. Roach 3 . 1 Center for<br />
Environmental Excellence, Air Force, San Antonio, TX,<br />
2 Toxic Substances Control, Cal EPA, Sacramento, CA<br />
and 3 Frontline Systems, Inc., San Antonio, TX.<br />
Sponsor: J. Christopher.<br />
#2081 SCREENING FOR POTENTIAL HEALTH RISKS<br />
FOLLOWING ACUTE EXPOSURE TO HEAVY<br />
METALS IN SOIL AT A FORMER MINING SITE.<br />
M. Pagliarulo and D. A. Manca. Standards Development<br />
Branch, Ontario Ministry <strong>of</strong> the Environment, Toronto,<br />
ON, Canada.<br />
#2082 RISK ASSESSMENT FOR IRON: USING THE<br />
INSTITUTE OF MEDICINE’S TOLERABLE<br />
UPPER INTAKE LEVEL AS A SURROGATE<br />
TOXICITY VALUE FOR IRON. M. L. Stifelman 1 , L.<br />
Ingerman 2 , W. C. Thayer 2 and G. L. Diamond 2 . 1 U.S.<br />
EPA, Seattle, WA and 2 Syracuse Research Corporation,<br />
Syracuse, NY.<br />
#2083 DETERMINING SOIL REMEDIAL ACTION<br />
CRITERIA FOR ACUTE EFFECTS: THE<br />
CHALLENGE OF COPPER. M. Seeley, C. S. Wells,<br />
S. Ren and B. D. Beck. Gradient Corporation,<br />
Cambridge, MA.<br />
#2084 PERCUTANEOUS ABSORPTION OF ARSENIC<br />
FROM ENVIRONMENTAL MEDIA. Y. Lowney 1 ,<br />
M. V. Ruby 1 , R. C. Wester 2 , R. A. Scho<strong>of</strong> 3 , S. E. Holm 4<br />
and H. I. Maibach 2 . 1 Exponent, Inc., Boulder, CO,<br />
2 3 University <strong>of</strong> California, San Francisco, CA, Integral<br />
Consulting, Inc., Mercer Island, WA and 4 Georgia<br />
Pacific Corporation, Atlanta, GA.<br />
#2085 THE ROLE OF METHYLATED METABOLITES<br />
IN INORGANIC ARSENIC-INDUCED CANCER:<br />
A SYNTHESIS OF INFORMATION FROM IN<br />
VITRO AND HUMAN BIOMONITORING<br />
STUDIES. A. Schoen and B. Beck. Gradient<br />
Corporation, Cambridge, MA.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 209
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2086 TOXICOLOGICAL EVALUATION OF 1, 1, 1-<br />
TRICHLOROETHANE AND RESULTING<br />
MINIMAL RISK LEVELS. H. Abadin 1 , D. M<strong>of</strong>fett 1 ,<br />
A. Dorsey 1 , C. Smith 1 and D. Wohlers 2 . 1 Agency for<br />
Toxic Substances and Disease Registry, Atlanta, GA and<br />
2 Environmental Science Center, Syracuse Research<br />
Corporation, Syracuse, NY. Sponsor: B. Fowler.<br />
#2087 PEAK EXPOSURE AND KINETICS OF TOLUENE<br />
IN MAN INCLUDING PBTK MODELLING<br />
EVALUATION. J. Bessems, A. Freidig, W. Meuling<br />
and J. Lammers. Food and Chemical Risk Analysis,<br />
TNO Chemistry, Zeist, Netherlands. Sponsor: V. Feron.<br />
#2088 A META-ANALYSIS OF NEUROBEHAVIORAL<br />
DEFICITS FROM LONG-TERM EXPOSURE TO<br />
STYRENE. W. K. Boyes 1 , A. M. Geller 1 , P. J.<br />
Bushnell 1 , G. M. Woodall 2 and V. A. Benignus 1 .<br />
1 NHEERL, U.S. EPA, Research Triangle Park, NC and<br />
2 NCEA, U.S. EPA, Research Triangle Park, NC.<br />
#2089 ROUTE-DEPENDENT EFFECTS OF TOLUENE<br />
ON SIGNAL DETECTION BEHAVIOR IN RATS.<br />
P. J. Bushnell 1 , T. E. Samsam 1 , W. M. Oshiro 1 , C. R.<br />
Eklund 2 and M. V. Evans 2 . 1 NHEERL /NTD, U.S. EPA,<br />
Research Triangle Park, NC and 2 NHEERL/ETD, U.S.<br />
EPA, Research Triangle Park, NC.<br />
#2090 WHY DO THE ACUTE BEHAVIORAL EFFECTS<br />
OF TOLUENE IN RATS DEPEND ON THE<br />
ROUTE OF EXPOSURE? T. E. Samsam, W. M.<br />
Oshiro and P. J. Bushnell. NHEERL/NTD, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#2091 ASSESSING THE IMPORTANCE OF THE<br />
BEHAVIORAL EFFECT OF ACUTE EXPOSURE<br />
TO TOLUENE IN HUMANS. V. A. Benignus 1,2 .<br />
1 Human Studies Division, U.S. EPA, Research Triangle<br />
Park, NC and 2 Neurotoxicology Division, U.S. EPA,<br />
Reasearch Triangle Park, NC. Sponsor: W. Boyes.<br />
#2092 CARDIOVASCULAR AND<br />
THERMOREGULATORY RESPONSE TO ORAL<br />
TOLUENE IN THE RAT. C. J. Gordon, W. M. Oshiro,<br />
T. E. Samsam, P. Becker and P. J. Bushnell.<br />
Neurotoxicology, U.S. EPA, Res. Tri. Park, NC.<br />
#2093 BENCHMARK DOSE ANALYSIS BASED ON<br />
STYRENE NEUROBEHAVIORAL META-DATA.<br />
G. M. Woodall 1 , W. K. Boyes 2 , A. M. Geller 2 , P. J.<br />
Bushnell 2 and V. A. Benignus 2 . 1 NCEA/ORD, U.S.<br />
EPA, Research Triangle Park, NC and 2 NHEERL/ORD,<br />
U.S. EPA, Research Triangle Park, NC.<br />
#2094 ACETYLCHOLINESTERASE AS THE CRITICAL<br />
EFFECT WHEN ESTIMATING THE SAFE DOSE<br />
FOR CHLORPYRIFOS? Q. J. Zhao, B. Gadagbui<br />
and M. Dourson. <strong>Toxicology</strong> Excellence for Risk<br />
Assessment (TERA), Cincinnati, OH.<br />
#2095 CHARACTERIZATION OF DELTAMETHRIN<br />
(DLT) METABOLISM IN ADULT MALE<br />
SPRAGUE-DAWLEY RATS. S. S. Anand 1 , W. T.<br />
Haines 4,3 , J. V. Bruckner 1 , J. W. Fisher 2 , S.<br />
Muralidhara 1 , D. L. Hunter 3 and S. Padilla 3 .<br />
1 Department.<strong>of</strong> Pharmaceutical and Biomedical<br />
Sciences, University <strong>of</strong> Georgia, Athens, GA,<br />
2 Department <strong>of</strong> Environmental Health Sciences.,<br />
University <strong>of</strong> Georgia, Athens, GA, 3 Neurotox.<br />
Division, U.S. EPA, Research Triangle Park, NC and<br />
4 Curr. in <strong>Toxicology</strong>., UNC-CH, Chapel Hill, NC.<br />
#2096 RISK OF TERATOGENICITY FROM<br />
TRICHLOROETHYLENE (TCE) AND<br />
DICHLOROETHYLENE (DCE) IN DRINKING<br />
WATER. B. J. Kelman 1 , B. D. Hardin 2 and R. L.<br />
Brent 3 . 1 GlobalTox, Redmond, WA, 2 GlobalTox, Hilton<br />
Head Island, SC and 3 Alfred I. DuPont Institute,<br />
Wilmington, DE.<br />
#2097 DOES TRICHLOROETHYLENE CONTRIBUTE<br />
TO CONGENITAL HEART DEFECTS? R. E.<br />
Watson 1 , W. Howard 2 and J. M. DeSesso 1 . 1 Biomedical<br />
Research Institute, Mitretek Systems, Falls Church, VA<br />
and 2 AFIOH/RSRE, US Air Force, Brooks City-Base,<br />
TX.<br />
#2098 HUMAN HEALTH RISK ASSESSMENT FOR 4-<br />
CHLORO-1, 2-BENZENEDIAMINE. V. Bhat, G.<br />
Ball, C. McLellan, C. Gillilland and J. Russell. NSF<br />
International, Ann Arbor, MI. Sponsor: M. Dourson.<br />
#2099 ADVERSE EFFECTS OF CYANOBACTERIAL<br />
PEPTIDES ON HUMAN HEALTH. S. Hoeger and D.<br />
Dietrich. Environmental <strong>Toxicology</strong>, University <strong>of</strong><br />
Konstanz, Konstanz, Germany.<br />
#2100 EXAMINING POTENCY FOR DEVELOPMENT<br />
OF THE PRELIMINARY CONTAMINANT<br />
CANDIDATE LIST (PRE-CCL). J. Donhue 1 , S.<br />
Kueberuwa 1 , Y. Selby-Mohamadu 2 and J. Shatkin 3 .<br />
1 Health and Ecological Criteria Division, U.S. EPA,<br />
Washington, DC, 2 Office <strong>of</strong> Ground Water and Drinking<br />
Warer, U.S. EPA, Washington, DC and 3 The Cadmus<br />
Group, Watertown, MA. Sponsor: E. Ohanian.<br />
#2101 CLASS-BASED DRINKING WATER ACTION<br />
LEVEL FOR ALKYL SUBSTITUTED<br />
NAPHTHALENES. A. Gebhart 1 , M. H. Whittaker 2 , T.<br />
Clipson Miller 2 and F. Hammer 1 . 1 Underwriters<br />
Laboratories Inc., Northbrook, IL and 2 ToxServices,<br />
Washington, DC.<br />
#2102 COMPARATIVE RISK ASSESSMENT OF<br />
MULTIMEDIA EXPOSURE TO PERCHLORATE<br />
AND OTHER AGENTS THAT INHIBIT IODIDE<br />
UPTAKE INTO THE THYROID GLAND. G. M.<br />
Bruce and R. C. Pleus. Intertox, Inc., Seattle, WA.<br />
#2103 HUMAN HEALTH RISK ASSESSMENT FOR<br />
THIOCYANATE. J. Russell, C. McLellan, G. Ball and<br />
V. Bhat. NSF International, Ann Arbor, MI. Sponsor:<br />
M. Dourson.<br />
#2104 DERIVATION OF A DRINKING WATER ACTION<br />
LEVEL FOR TRIBUTYL PHOSPHATE. T. Clipson<br />
Miller 1 , M. H. Whittaker 1 , A. Gebhart 2 and F. Hammer 2 .<br />
1 ToxServices, Washington., DC and<br />
2 Underwriters<br />
Laboratories Inc., Northbrook, IL.<br />
210<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2105 CONSIDERATION OF SENSITIVE<br />
POPULATIONS FOR RISK ASSESSMENT OF<br />
CHEMICALS IN DRINKING WATER. A. Fan, R. A.<br />
Howd and G. Alexeeff. OEHHA, Cal/EPA, Oakland,<br />
CA.<br />
#2106 INHALATION EXPOSURE TO NONVOLATILE<br />
CHEMICALS DURING SHOWERING D M<br />
MANGANARO M S HUTCHESON T ZEWDIE.<br />
MASSACHUSETTS DEPARTMENT OF<br />
ENVIRONMENTAL PROTECTION, BOSTON<br />
MA, USA. T. Zewdie, D. M. Manganaro and M. S.<br />
Hutcheson. Office <strong>of</strong> Research and Standards,<br />
Massacusetts Department <strong>of</strong> Environmental Protection,<br />
Boston, MA.<br />
#2107 MEASUREMENT OF AIR CONCENTRATION OF<br />
D CIS/TRANS ALLETHRIN GENERATED BY A<br />
MOSQUITO REPELLENT LAMP IN AN<br />
OUTDOOR ENVIRONMENT. S. Selim 1 and J. J.<br />
Olson 2 . 1 Golden Pacific Laboratory, Fresno, CA and<br />
2 Product <strong>Toxicology</strong>, S. C. Johnson & Son Inc., Racine,<br />
WI.<br />
#2108 MECHANOTRANSDUCTION IN PARTICLE<br />
TOXICOLOGY. S. C. Brown 1 , M. Kamal 2 , N.<br />
Nasreen 2 , V. Antony 2 and B. Moudgil 1 . 1 Particle<br />
Engineering Research Center and Department <strong>of</strong><br />
Materials Science, University <strong>of</strong> Florida, Gainesville,<br />
FL and 2 Division <strong>of</strong> Pulmonary and Critical Care<br />
Medicine, University <strong>of</strong> Florida, Gainesville, FL.<br />
Sponsor: S. Roberts.<br />
#2109 A QUANTITATIVE CANCER RISK ASSESSMENT<br />
FOR AIRBORNE ASBESTOS GENERATED BY<br />
VEHICULAR TRAFFIC ON A ROAD PAVED<br />
WITH ASBESTOS-CONTAINING SERPENTINE<br />
ROCK. J. D. Budroe 1 , R. Fears 2 , F. Collier 2 , A.<br />
Salmon 1 and M. A. Marty 1 . 1 Office <strong>of</strong> Environmental<br />
Health Hazard Assessment (OEHHA), Oakland, CA and<br />
2 Department <strong>of</strong> Toxic Substances Control, Sacramento,<br />
CA.<br />
#2110 IMPROVED DOSIMETRIC ADJUSTMENT<br />
FACTORS FOR INTERSPECIES<br />
EXTRAPOLATION OF INHALED, POORLY<br />
SOLUBLE PARTICLES. B. Asgharian 1 , O. Price 1 , A.<br />
Jarabek 2,1 and F. Miller 1 . 1 Division <strong>of</strong> Computational<br />
Biology, CIIT Centers for Health Research, Research<br />
Triangle Park, NC and 2 National Center for<br />
Environmental Assessment, U.S. EPA, Washington DC,<br />
DC.<br />
#2111 DEVELOPMENT OF A CHRONIC INHALATION<br />
REFERENCE EXPOSURE LEVEL FOR<br />
RESPIRABLE CRYSTALLINE SILICA. J. F.<br />
Collins, A. G. Salmon, J. P. Brown, M. A. Marty and G.<br />
V. Alexeeff. OEHHA, California EPA, Oakland, CA.<br />
#2112 EFFECT OF ARSENIC AND DIELDRIN ON<br />
FEMALE RATS: PRELIMINARY DOSE RANGE<br />
STUDIES. L. Ogden 1 , R. R. Dalvi 1 , M. Mansour 1 , T.<br />
Graham 2 , L. Billups 2 and T. Datiri 1 . 1 Biomedical<br />
Sciences, Tuskegee University, Tuskegee, AL and<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: RENAL TOXICOLOGY<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM–10:00 AM<br />
2 Pathobiology, Tuskegee University, Tuskegee, AL.<br />
Chairperson(s): Lu Cai, University <strong>of</strong> Louisville, Louisville, KY and Monica<br />
Valentovic, Marshall University, Huntington, WV.<br />
#2113 CHARACTERIZATION OF ISCHEMIA-<br />
REPERFUSION EFFECTS IN RENAL CELLS — A<br />
SCREENING APPROACH. A. Heussner, E. O’Brien<br />
and D. Dietrich. Environmental <strong>Toxicology</strong>, University<br />
<strong>of</strong> Konstanz, Konstanz, Germany.<br />
#2114 OCHRATOXIN A- INDUCED GENE<br />
EXPRESSION DEREGULATIONS IN THE<br />
KIDNEY OF EKER RATS ANALYZED ON<br />
AFFYMETRIX CHIPS. K. Stemmer 1 , H. Ellinger 2 , T.<br />
Lampertsdoerfer 1 , M. Thiel 2 , H. Ahr 2 and D. Dietrich 1 .<br />
1 University <strong>of</strong> Konstanz, Konstanz, Germany and<br />
2 Molecular and Genetic <strong>Toxicology</strong>, Bayer Health Care<br />
AG, Germany, Germany, Germany.<br />
#2115 CHARACTERIZATION OF OCHRATOXIN A-<br />
TRANSPORTING ORGANIC ANION<br />
TRANSPORTERS IN RENAL CELLS. M. Biester,<br />
E. O’Brien, A. Heussner and D. Dietrich.<br />
Environmental <strong>Toxicology</strong>, University <strong>of</strong> Konstanz,<br />
Konstanz, Germany.<br />
#2116 CYTOTOXICITY OF THE NEPHROTOXINS<br />
ARISTOLOCHIC ACID AND MAM-ACETATE ON<br />
HUMAN AND PORCINE KIDNEY CELL LINES<br />
AND PRIMARY KIDNEY CORTEX CELLS. S.<br />
Huljic 1 , E. Dorr 2 , B. Brune 2 and D. Dietrich 1 .<br />
1 University <strong>of</strong> Konstanz, Konstanz, Germany and<br />
2 University <strong>of</strong> Kaiserslautern, Kaiserslautern, Germany.<br />
#2117 EFFECT OF ETHYLENE GLYCOL<br />
METABOLITES ON VARIOUS CYTOTOXICITY<br />
PARAMETERS IN HUMAN PROXIMAL TUBULE<br />
CELLS. C. Guo, Y. Li, B. Crenshaw and K. McMartin.<br />
Pharmacology, LSU Health Sciences Center,<br />
Shreveport, LA.<br />
#2118 PEROXIREDOXINS ARE MODIFIED BY<br />
QUINONE-GENERATED REACTIVE OXYGEN<br />
SPECIES. J. Dong 1,2 , M. Person 1 , S. C. Hensley 3 , J.<br />
Shen 3 , S. S. Lau 2 and T. J. Monks 2 . 1 Division <strong>of</strong><br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Texas at<br />
Austin, Austin, TX, 2 Department <strong>of</strong> Pharmacology and<br />
<strong>Toxicology</strong>, University <strong>of</strong> Arizona Health Sciences<br />
Center, Tucson, AZ and 3 Department <strong>of</strong> Carcinogenesis,<br />
University <strong>of</strong> Texas M. D. Anderson Cancer Center,<br />
Science Park-Research Division, Smithville, TX.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 211
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2119 UP-REGULATION OF HEAT SHOCK PROTEIN<br />
27 AND RETINOL BINDING PROTEIN<br />
CONTRIBUTES TO 11-DEOXY-16, 16-DIMETHYL<br />
PROSTAGLANDIN E2 MEDIATED<br />
CYTOPROTECTION. J. L. Lord 1 , Z. Jia 1 , D. W.<br />
Cromey 2 , R. C. Lantz 2 , T. J. Monks 1 and S. S. Lau 1 .<br />
1 Department <strong>of</strong> Pharmacology& <strong>Toxicology</strong>, College <strong>of</strong><br />
Pharmacy, University <strong>of</strong> Arizona, Tucson, AZ and 2 Cell<br />
Biol & Anat, College <strong>of</strong> Medicine, University <strong>of</strong><br />
Arizona, Tucson, AZ.<br />
#2120 ASSESSMENT OF IN VITRO TOXICITY OF<br />
SELECTED CHEMO-THERAPUETIC DRUGS<br />
USING HUMAN PRIMARY RENAL CELLS. W. Li,<br />
M. Lam, A. Birkeland, L. Warfe, D. Choy, J. Post and<br />
M. Sullivan. Pharmacology, Berlex, Richmond, CA.<br />
#2121 NEPHROTOXICITY OF N-(3, 5-<br />
DICHLOROPHENYL)-3-<br />
HYDROXYSUCCINAMIC ACID IN MALE AND<br />
FEMALE FISCHER 344 RATS. G. O. Rankin, D. K.<br />
Anestis, K. R. Saunders and S. K. Hong. Pharmacology,<br />
Marshall University, Huntington, WV.<br />
#2122 COMPARISON OF THE IN VITRO<br />
NEPHROTOXIC POTENTIAL OF DICLOFENAC<br />
AND ACETAMINOPHEN IN ISOLATED RENAL<br />
PROXIMAL TUBULES FROM MALE FISCHER<br />
344 RATS. S. L. Miles, J. G. Ball and G. O. Rankin.<br />
Pharmacology, Marshall University, Huntington, WV.<br />
#2123 IN VITRO GSH ADDUCT FORMATION:<br />
EVIDENCE FOR BIOACTIVATION OF THE<br />
NEPHROTOXICANT N-(3, 5-<br />
DICHLOROPHENYL)SUCCINIMIDE THROUGH<br />
ALCOHOL-O-GLUCURONIDATION AND<br />
SULFATION. D. Cui 1,2 , G. O. Rankin 3 and P. J.<br />
Harvison 1 . 1 Department <strong>of</strong> Pharmaceutical Sciences,<br />
University <strong>of</strong> the Sciences in Philadelphia, Philadelphia,<br />
PA, 2 Department <strong>of</strong> Pharmaceutical Candidates<br />
Optimization, Bristol-Myers Squibb, Princeton, NJ and<br />
3 Department <strong>of</strong> Pharmacology, Marshall University<br />
School <strong>of</strong> Medicine, Huntington, WV.<br />
#2124 EFFECT OF ENANTIOMER-BASED INHIBITORS<br />
OF CA 2+ -INDEPENDENT PHOSPHOLIPASE A 2<br />
ON RENAL AND CANCER CELL DEATH. L.<br />
Zhang, W. Zhang and B. S. Cummings. Pharmaceutical<br />
and Biomedical Sciences, University <strong>of</strong> Georgia,<br />
Athens, GA.<br />
#2125 IDENTIFICATION AND CHARACTERIZATION<br />
OF IPLA γ IN MITOCHONDRIA. G. R. Kinsey 1 , J.<br />
McHowat 2 and R. G. Schnellmann 1 . 1 Pharmaceutical<br />
Sciences, Medical University <strong>of</strong> South Carolina,<br />
Charleston, SC and 2 Pathology, St. Louis University, St.<br />
Louis, MO.<br />
#2126 ISCHEMIA-INDUCED CLEAVAGE OF<br />
CADHERINS IN NRK CELLS: EVIDENCE FOR<br />
A ROLE OF MT1-MMP. M. Pulido 1 , K. Bayless 2 , R.<br />
Burghardt 3 , G. Davis 2 and A. Parrish 1 . 1 Pharmacology<br />
and <strong>Toxicology</strong>, Texas A&M University System Health<br />
Science Center, College Station, TX, 2 Pathology, Texas<br />
A&M University System Health Science Center,<br />
College Station, TX and 3 Veterinary Anatomy, Texas<br />
A&M University, College Station, TX.<br />
#2127 ROLE OF HEAT SHOCK PROTEINS AND<br />
SIGNALING PATHWAYS IN DETERMINING<br />
RESPONSE OF HUMAN PROXIMAL TUBULAR<br />
CELLS TO S-(1, 2-DICHLOROVINYL)-L-<br />
CYSTEINE (DCVC). D. A. Putt, L. H. Lash, S. E.<br />
Hueni and B. P. Horwitz. Pharmacology, Wayne State<br />
University Sch. Med., Detroit, MI.<br />
#2128 IDENTIFICATION AND LOCALIZATION OF<br />
CALPAIN 10 TO MITOCHONDRIA. D. Arrington<br />
and R. G. Schnellmann. Pharmaceutical Sciences,<br />
MUSC, Charleston, SC.<br />
#2129 EPITHELIAL BARRIER CHARACTERISTICS<br />
AND EXPRESSION OF CELL ADHESION<br />
MOLECULES IN PROXIMAL TUBULE-<br />
DERIVED CELL LINES COMMONLY USED FOR<br />
IN VITRO NEPHROTOXICITY TESTING. W. C.<br />
Prozialeck, P. C. Lamar and C. S. Smith. Pharmacology,<br />
Midwestern University, Downers Grove, IL.<br />
#2130 CYTOTOXICITY AND METABOLISM OF S-1, 2-<br />
DICHLOROVINYL-GLUTATHIONE (DCV-GSH)<br />
AND CHLORAL (CH) BY HUMAN PROXIMAL<br />
TUBULE CELLS (HPTC) IN CULTURE. E. A. Lock,<br />
L. Tolliver-Ho and R. G. Schnellmann. Pharmaceutical<br />
Sciences, Medical University <strong>of</strong> South Carolina,<br />
Charleston, SC.<br />
#2131 PROTEOMIC CHARACTERIZATION OF THE<br />
EFFECTS OF A KINASE INHIBITOR ON<br />
PROTEIN EXPRESSION IN RAT KIDNEY. J.<br />
Leonard 1 , M. Courcol 1 , E. Boitier 1 , M. Duchesne 2 , F.<br />
Parker 2 , Z. Jayyosi 3 , R. A. Roberts 1,4 and J. Gautier 1 .<br />
1 Drug Safety Evaluation, San<strong>of</strong>i Aventis, Vitry-sur-<br />
Seine, France, 2 Functional Genomics, San<strong>of</strong>i Aventis,<br />
Vitry-sur-Seine, France, 3 Drug Safety Evaluation,<br />
San<strong>of</strong>i Aventis, Bridgewater, NJ and 4 Safety Assessment<br />
(current address), Astra Zeneca, Alderley Park, United<br />
Kingdom.<br />
#2132 REGULATION OF GRP78 IN THE<br />
GLOMERULAR MESANGIAL CELL STRESS<br />
RESPONSE. A. Nanez 1,2 , H. Falahatpisheh 1,2 , Y.<br />
Qian 3 , E. Tiffany-Castiglioni 3 and K. S. Ramos 1,2 .<br />
1 Biochemistry and Molecular Biology, University <strong>of</strong><br />
Louisville, Louisville, KY, 2 Center for Genetics and<br />
Molecular Medicine, University <strong>of</strong> Louisville, Louiville,<br />
KY and 3 Department <strong>of</strong> Veterinary Anatomy & Public<br />
Health, Texas A&M University, College Station, TX.<br />
#2133 REDUCTION OF CYCLOSPORIN A<br />
NEPHROTOXICITY BY GADOLINIUM<br />
CHLORIDE. Z. Zhong and J. Sun. Cell and<br />
Developmental Biology, University <strong>of</strong> North Carolina,<br />
Chapel Hill, NC. Sponsor: J. Lemasters.<br />
#2134 THE EFFECT OF S-ADENOSYL-L-METHIONINE<br />
(SAME) AND ASCORBIC ACID ON P-<br />
AMINOPHENOL TOXICITY IN RENAL SLICES.<br />
M. Valentovic, R. Harmon and D. Hoover.<br />
Pharmacology, Marshall University School <strong>of</strong> Medicine,<br />
Huntington, WV.<br />
212<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2135 HUMAN PRECISION-CUT KIDNEY-CORTEX<br />
SLICES AS A TOXICOLOGY MODEL FOR<br />
EVALUATING THE HYPERAMMONEMIC<br />
EFFECT OF VALPROATE: A CARBON 13 NMR<br />
STUDY. G. Baverel, A. Vittorelli, C. Gauthier, C.<br />
Michoudet and G. Martin. Metabolic and Renal<br />
Pathophysiology, INSERM U499, Lyon Cedex 08,<br />
France. Sponsor: J. Descotes.<br />
#2136 UTILITY OF A SUBCLINICAL RENAL INJURY<br />
MODEL IN RATS FOR DETECTION OF<br />
INCREASED SENSITIVITY TO SITE-SPECIFIC<br />
NEPHROTOXIC METALS. E. F. Madden, R. P.<br />
Brown and P. L. Goering. Center for Devices and<br />
Radiological Health, U.S. FDA, Silver Spring, MD.<br />
#2137 PREPLACED RENAL CELL DIVISION IS THE<br />
CRITICAL MECHANISM OF PROTECTION IN<br />
MICE AGAINST S-1, 2-DICHLOROVINYL-L-<br />
CYSTEINE-INDUCED ACUTE RENAL FAILURE<br />
AND DEATH. M. C. Korrapati 1 , J. Chilakapati 1 , E. A.<br />
Lock 2 , J. Latendresse 3 , A. Warbritton 3 and H. M.<br />
Mehendale 1 . 1 ULM, Monroe, LA, 2 MUSC, Charleston,<br />
SC and 3 NCTR, Jefferson, AR.<br />
#2138 INHIBITION OF TISSUE REPAIR LEADS TO<br />
PROGRESSION OF INJURY, ACUTE RENAL<br />
FAILURE AND DEATH IN MICE. R. N. Reddy and<br />
H. M. Mehendale. Toxciology, University <strong>of</strong> Lousiana<br />
Monroe, Monroe, LA.<br />
#2139 ROLE OF LOWER PROGRESSION OF DCVC-<br />
INITIATED RENAL INJURY IN DIABETES-<br />
INDUCED PROTECTION FROM<br />
NEPHROTOXICITY. A. V. Dnyanmote 1 , H. M.<br />
Mehendale 1 , E. A. Lock 2 and J. R. Latendresse 3 .<br />
1 <strong>Toxicology</strong>, University <strong>of</strong> Louisiana at Monroe,<br />
Monroe, LA, 2 Pharmaceutical Sciences, MUSC,<br />
Charleston, SC and 3 Pathology Associates Intl., NCTR,<br />
Jefferson, AR.<br />
#2140 TISSUE DISTRIBUTION AND RENAL<br />
ONTOGENY OF ORGANIC CATION<br />
TRANSPORTERS IN MICE. Y. M. Alnouti, J. S.<br />
Petrick, T. R. Knight and C. D. Klaassen. University <strong>of</strong><br />
Kansas Medical Center, Kansas City, KS.<br />
#2141 DIETARY MODULATION OF THE RENAL<br />
TOXICITY OF P-NONYLPHENOL (NP) IN<br />
SPRAGUE-DAWLEY RATS. S. Cooper 1 , X. Fu 1 , J. R.<br />
Latendresse 2 and K. B. Delclos 1 . 1 NCTR, Jefferson, AR<br />
and 2 Charles River Laboratories, Jefferson, AR.<br />
#2142 ETIOLOGY OF HYDRONEPHROSIS WITHOUT<br />
OBSTRUCTION IN THE MOUSE KIDNEY BY<br />
LACTATIONAL EXPOSURE TO DIOXIN. N.<br />
Nishimura 1 , J. Yonemoto 1 , Y. Takeuchi 1 , C. Yokoi 1 , H.<br />
Nishimura 3 and C. Tohyama 2 . 1 Endocrine Disruptors<br />
and Dioxin Project, National Institute for Environmental<br />
Studiess and Dioxin Project, Tsukuba, Japan,<br />
2 Environmental Health Sciences Division, National<br />
Institute for Environmental Studies, Tsukuba, Japan and<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: PESTICIDES<br />
Chairperson(s): Derek Gammon, CAL-EPA, Sacramento, CA and Kevin<br />
Cr<strong>of</strong>ton, U.S. EPA, Research Triangle Park, NC.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 10:00 AM–11:30 AM<br />
#2143 EFFECTS OF CONAZOLE FUNGICIDES ON<br />
DEVELOPMENT AND PARTURITION IN THE<br />
RAT. M. G. Narotsky 1 , J. C. Rockett 1 , C. R. Blystone 2 ,<br />
A. K. Goetz 2 , H. Ren 1 , D. S. Best 1 , H. P. Nichols 1 , J. E.<br />
Schmid 1 and D. J. Dix 1 . 1 Reproductive <strong>Toxicology</strong><br />
Division, U.S. EPA, ORD, NHEERL, Research Triangle<br />
Park, NC and 2 Department <strong>of</strong> Environmental and<br />
Molecular <strong>Toxicology</strong>, North Carolina State University,<br />
Raleigh, NC.<br />
#2144 TRIADIMEFON INDUCES RAT THYROID<br />
TUMORS THROUGH A NON-TSH MEDIATED<br />
MODE OF ACTION. D. C. Wolf 1 , J. Allen 1 , G. Sun 1 ,<br />
J. R. Thibodeaux 2 , M. George 1 , S. D. Hester 1 , S. Thai 1 ,<br />
D. Delker 1 , G. Nelson 1 , E. Winkfield 1 , B. Roop 1 , S.<br />
Leavitt 1 , W. Ward 1 and S. C. Nesnow 1 . 1 Environmental<br />
Carcinogenesis Division, U.S. EPA, Research Triangle<br />
Park, NC and 2 Reproductive <strong>Toxicology</strong> Division, U.S.<br />
EPA, Research Triangle Park, NC.<br />
#2145 MYCLOBUTANIL AND TRIADIMEFON<br />
METABOLISM BY RAT CYP ISOFORMS AND<br />
LIVER MICROSOMES. J. Tang 1 , Y. Sey 2 , R.<br />
Murrel 3 , J. Rockett 4 , D. Dix 4 and H. Barton 2 .<br />
1 Curriculum in <strong>Toxicology</strong>, UNC-Chapel Hill, Chapel<br />
Hill, NC, 2 Experimental <strong>Toxicology</strong> Division, U.S. EPA<br />
NHEERL, Research Triangle Park, NC, 3 Department <strong>of</strong><br />
Environmental and Molecular <strong>Toxicology</strong>, NC State<br />
University, Raleigh, NC and 4 Reproductive <strong>Toxicology</strong><br />
Division, U.S. EPA NHEERL, Research Triangle Park,<br />
NC.<br />
#2146 COMPARATIVE LIVER P450 ENZYME<br />
ACTIVITY AND HISTOPATHOLOGY IN MICE<br />
TREATED WITH THE CONAZOLE<br />
FUNGICIDES: MYCLOBUTANIL,<br />
PROPICONAZOLE AND TRIADIMEFON. J. Allen,<br />
D. C. Wolf, M. George, S. D. Hester, G. Sun, S. Thai, D.<br />
Delker, G. Nelson, E. Winkfield, B. Roop, S. Leavitt,<br />
W. Ward and S. C. Nesnow. Environmental<br />
Carcinogenesis Division, U.S. EPA, Research Triangle<br />
Park, NC.<br />
3 Aichi Mizuho University, Toyota, Japan.<br />
#2147 COMPARISON OF HEPATIC GENE<br />
EXPRESSION PROFILES FROM MICE<br />
EXPOSED TO THREE TOXICOLOGICALLY<br />
DIFFERENT CONAZOLES. W. Ward, S. D. Hester,<br />
S. Thai, J. Allen, C. Jones, D. C. Wolf and S. Nesnow.<br />
Environmental Carcinogenesis Division, U.S. EPA,<br />
Research Triangle Park, NC.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 213
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2148 REPRODUCTIVE EFFECTS OF EXPOSURE TO<br />
CONAZOLE FUNGICIDES IN THE MALE RAT.<br />
A. K. Goetz 1 , C. Blystone 1 , H. Ren 2 , J. E. Schmid 2 , H.<br />
P. Nichols 2 , W. Bao 2 , D. S. Best 2 , M. G. Narotsky 2 , D.<br />
C. Wolf 2 , J. C. Rockett 2 and D. J. Dix 2 . 1 Department <strong>of</strong><br />
Environmental and Molecular <strong>Toxicology</strong>, North<br />
Carolina State University, Raleigh, NC and 2 NHEERL,<br />
Office <strong>of</strong> Research and Development, U.S. EPA,<br />
Research Triangle Park, NC.<br />
#2149 COMPARISON OF GENE EXPRESSION<br />
PROFILES FROM RATS FED THREE<br />
TOXICOLOGICALLY DIFFERENT<br />
CONAZOLES. S. Hester, S. Thai, D. C. Wolf, W. Ward<br />
and S. C. Nesnow. Environmental Carcinogenesis<br />
Division, U.S. EPA, Research Triangle Park, NC.<br />
#2150 PROFILING GENE EXPRESSION IN HUMAN<br />
H295R ADRENOCORTICAL CARCINOMA<br />
CELLS AND RAT TESTES TO IDENTIFY<br />
PATHWAYS OF TOXICITY FOR CONAZOLE<br />
FUNGICIDES. H. Ren 1 , J. E. Schmid 1 , J. Retief 2 , Y.<br />
Turpaz 2 , X. Zhang 3 , P. D. Jones 3 , J. L. Newsted 4 , J. P.<br />
Giesy 3 , D. C. Wolf 1 , C. R. Wood 1 , W. Bao 1 and D. J.<br />
Dix 1 . 1 NHEERL/ORD, U.S. EPA, Research Triangle<br />
Park, NC, 2 Affymetrix Inc., Santa Clara, CA,<br />
3 Department <strong>of</strong> Zoology, Michigan State University,<br />
East Lansing, MI and 4 ENTRIX Inc., East Lansing, MI.<br />
#2151 REPRODUCTIVE TOXICITY OF EXPOSURE TO<br />
CONAZOLE FUNGICIDES IN THE FEMALE<br />
RAT. J. C. Rockett 1 , M. G. Narotsky 1 , I.<br />
Thillainadarajah 1 , C. R. Blystone 2,1 , A. K. Goetz 2,1 , H.<br />
Ren 1 , D. S. Best 1 , R. N. Murrell 2,1 , H. P. Nichols 1 , J. E.<br />
Schmid 1 , K. E. Thompson 3 and D. J. Dix 1 .<br />
1 RTD/NHEERL/ORD, U.S. EPA, Research Triangle<br />
Park, NC, 2 Department <strong>of</strong> Environmental and Molecular<br />
<strong>Toxicology</strong>, North Carolina State University, Raleigh,<br />
NC and 3 Reproductive <strong>Toxicology</strong>, Pharmaceutical<br />
Research Institute, Bristol-Myers Squibb Company,<br />
New Brunswick, NJ.<br />
#2152 A RISK ASSESSMENT OF THE TRIAZINE<br />
HERBICIDE ATRAZINE. D. W. Gammon, C. N.<br />
Aldous, W. C. Carr, J. R. Sanborn and K. F. Pfeifer.<br />
Department <strong>of</strong> Pesticide Regulation, California EPA,<br />
Sacramento, CA.<br />
#2153 METHOXYCHLOR INHIBITS EXPRESSION OF<br />
ANTIOXIDANT ENZYMES IN THE MOUSE<br />
OVARY. R. K. Gupta, K. P. Miller, D. Tomic and J. A.<br />
Flaws. <strong>Toxicology</strong>, University <strong>of</strong> Maryland at<br />
Baltimore, Baltimore, MD.<br />
#2154 TRANSIENT ACTIVATION OF<br />
ACETYLCHOLINESTERASE BY PARAOXON. C.<br />
A. Rosenfeld 1 and L. G. Sultatos 2 . 1 Drug Metabolism<br />
and Pharmacokinetics, Schering-Plough Research<br />
Institute, Lafayette, NJ and 2 Pharmacology &<br />
Physiology, UMD New Jersey Medical School, Newark,<br />
NJ.<br />
#2155 EVALUATION FOR THE ADDITIVE TOXIC<br />
INFLUENCE OF ORGANOPHOSPHORUS<br />
PESTICIDES. M. Tahara 1,2 , R. Kubota 1 , H.<br />
Nakazawa 2 , A. Hirose 3 , M. Ema 3 , H. Tokunaga 1 and T.<br />
Nishimura 1 . 1 Division <strong>of</strong> Environmental Chemistry,<br />
National Institute <strong>of</strong> Health Sciences, Tokyo, Japan,<br />
2 Department <strong>of</strong> Analytical Chemistry, Hoshi University,<br />
Tokyo, Japan and 3 Division <strong>of</strong> Risk Assessment,<br />
Biological, Safety Research Center, National Institute <strong>of</strong><br />
Health Sciences, Tokyo, Japan.<br />
#2156 BIOLOGICAL MONITORING OF EXPOSURE TO<br />
ORGANOPHOSPHORUS INSECTICIDES IN<br />
GREENHOUSE WORKERS. M. Bouchard 1,3 , G.<br />
Carrier 1 , R. C. Brunet 2 , N. Noisel 1 , G. Labarre 1 , P.<br />
Dumas 3 and J. Weber 3 . 1 Environmental and<br />
Occupational Health, University <strong>of</strong> Montreal, Montreal,<br />
QC, Canada, 2 Mathematics and statistics, University <strong>of</strong><br />
Montreal, Montreal, QC, Canada and 3 Risques<br />
biologiques, environnementaux et occupationnels,<br />
Institut national de sante publique du Quebec, Montreal,<br />
QC, Canada.<br />
#2157 KINETIC DATA ON PESTICIDE METABOLISM<br />
IN HUMANS TO ALLOW PBPK/PD MODELS<br />
FOR PARATHION AND CHLORPYRIFOS TO<br />
PREDICT SUSCEPTIBILITY. J. R. Olson, J. B.<br />
Knaak, B. P. McGarrigle, K. M. Kransler, R. J.<br />
Foxenberg and P. J. Kostyniak. Pharmacology and<br />
<strong>Toxicology</strong>, SUNY at Buffalo, Buffalo, NY.<br />
#2158 ORGANOPHOSPHORUS PESTICIDES INHIBIT<br />
PRENYLATED METHYLATED PROTEIN<br />
METHYL ESTERASE. N. S. Lamango. College <strong>of</strong><br />
Pharmacy and Pharmaceutical Sciences, Florida A&M<br />
University, Tallahassee, FL. Sponsor: A. Ndifor.<br />
#2159 ASSESSING EXPOSURES TO FLEA CONTROL<br />
INSECTICIDES FROM THE FUR OF DOGS<br />
TREATED WITH FLEA COLLARS. K. Davis 1 , J.<br />
Chambers 1 , J. Moran 1 , N. Holifield 1 and S. Boone 2 .<br />
1 Basic Science, Mississippi State University,<br />
Mississippi State, MS and 2 U.S. EPA, Stennis Space<br />
Center, MS.<br />
#2160 EFFECT OF PYRETHRINS ON CYTOCHROME<br />
P450 FORMS IN CULTURED RAT AND HUMAN<br />
HEPATOCYTES. B. G. Lake 1 , R. J. Price 1 , A. M.<br />
Giddings 1 , C. Meredith 1 and T. G. Osimitz 2 . 1 Molecular<br />
Sciences, BIBRA International Ltd.,, Carshalton, Surrey,<br />
United Kingdom and 2 Science Strategies LLC,<br />
Charlottesville, VA.<br />
#2161 RELATIVE POTENCIES FOR ACUTE EFFECTS<br />
OF PYRETHROIDS ON MOTOR FUNCTION IN<br />
RATS. M. J. Wolansky 1 , M. J. DeVito 2 , C. Gennings 3 ,<br />
W. Carter 3 , R. A. Carchman 3 and K. M. Cr<strong>of</strong>ton 2 .<br />
1 National Research Council, Research Triangle Park,<br />
NC, 2 NTD and ETD, U.S. EPA, Research Triangle Park,<br />
NC and 3 Solveritas, LLC, Richmond, VA.<br />
THURSDAY<br />
214<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2162 USING ARRAY TECHNOLOGY TO IDENTIFY<br />
POTENTIAL BIOMARKERS FOR PYRETHROID<br />
INSECTICIDES. J. Harrill 1 , M. J. Wolansky 2 , S.<br />
Hester 3 , J. M. Hedge 4 and K. M. Cr<strong>of</strong>ton 4,1 .<br />
1 Curriculum in <strong>Toxicology</strong>, University <strong>of</strong> North<br />
Carolina, Chapel Hill, NC, 2 National Research Council,<br />
Research Triangle Park, NC, 3 ETD, NHEERL, ORD,<br />
U.S. EPA, Research Triangle Park, NC and 4 NTD,<br />
NHEERL, ORD, U.S. EPA, Research Triangle Park,<br />
NC.<br />
#2163 ACTIVATION OF MITOGEN-ACTIVATED<br />
PROTEIN KINASE AND TRANSCRIPTIONAL<br />
FACTORS PRECEDES CYCLOOXYGENASE-2<br />
GENE EXPRESSION IN MACROPHAGES<br />
EXPOSED TO THE O, P- DDT. J. Kim 1,2 , E. Han 1,2<br />
and H. Jeong 1,2 . 1 Pharmacy, Chosun University,<br />
Kwangju, South Korea and 2 Research Center for<br />
Proteineous Materials, Chosun University, Kwangju,<br />
South Korea.<br />
#2164 SUCCESSFUL ELIMINATION OF PARAQUAT BY<br />
HEMOPERFUSION USING PULSATILE<br />
EXTRACORPOREAL CIRCULATION. E. Hwang 1 ,<br />
S. Lee 2 , J. Hwang 2 , J. Lee 3 , C. Lee 4 and Y. Kim 1 .<br />
1 Department <strong>of</strong> Thoracic and Cardiovascular Surgery,<br />
Konkuk University Chungju Hospital, Chungju, South<br />
Korea, 2 Department <strong>of</strong> Thoracic and Cardiovascular<br />
Surgery, Konkuk University Hospital, Seoul, South<br />
Korea, 3 Department <strong>of</strong> Emergency Medicine, Konkuk<br />
University Chungju Hospital, Chungju, South Korea<br />
and 4 Department <strong>of</strong> Diagnostic and Experimental<br />
Medicine, Konkuk University Chungju Hospital,<br />
Chungju, South Korea.<br />
#2165 DDT-INDUCED AROMATASE AND<br />
CYCLOOXYGENASE-2 GENE EXPRESSION IN<br />
TESTICULAR LEYDIG R2C CELLS. D. Oh 1,2 and<br />
H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea and 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea.<br />
#2166 INDUCTION OF CYP3A4 BY O, P’-DDT IN<br />
HEPG2 CELLS. I. M. Medina and G. Elizondo-<br />
Azuela. <strong>Toxicology</strong>, CINVESTAV-IPN, Mexico City,<br />
D.F., Mexico. Sponsor: B. Quintanilla-Vega.<br />
#2167 N-DEALKYLATION IS A KEY DETERMINANT<br />
IN THE HEPATOTOXICITY OF<br />
CHLOROACETANILIDE HERBICIDE<br />
ALACHLOR. V. M. Kale and S. A. Meyer. <strong>Toxicology</strong>,<br />
University <strong>of</strong> Louisiana at Monroe, Monroe, LA.<br />
#2168 TRIBUTYLTIN REGULATED STEROIDOGENIC<br />
ENZYME GENES EXPRESSION AND CHANGES<br />
SEXUAL HORMONE IN MOUSE TESTICULAR<br />
LEYDIG CELLS. H. Kim 1,2 , K. Lee 1 , K. Jung 1,2 , D.<br />
Oh 1,2 , K. Oh 1,2 , J. Choi 1,2 and H. Jeong 1,2 . 1 Pharmacy,<br />
Chosun University, Kwangju, South Korea and<br />
2 Research Center for Proteineous Materials, Chosun<br />
University, Kwangju, South Korea.<br />
#2169 TRIBUTYLTIN INDUCE CELL CYCLE ARREST<br />
IN RAT TESTICULAR LEYDIG CELLS. D. Kim 3 ,<br />
K. Lee 1,2 , D. Oh 1,2 , J. Kim 1,2 , H. Kim 1,2 , D. Shin 1,2 and<br />
H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju,<br />
South Korea, 2 Research Center for Proteineous<br />
Materials, Chosun University, Kwangju, South Korea<br />
and 3 Pathology, College <strong>of</strong> Oriental Medicine, Daejeon<br />
University, Daejeon, South Korea.<br />
#2170 THE BIPYRIDYL HERBICIDE PARAQUAT<br />
CAUSES OXIDATIVE STRESS-MEDIATED<br />
TOXICITY IN HUMAN NEUROBLASTOMA SH-<br />
SY5Y CELLS: RELEVANCE TO PARKINSON`S<br />
DISEASE. W. Yang and E. Tiffany-Castiglioni.<br />
Veterinary Integrative Biosciences, Texas A&M<br />
University, College Station, TX.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: DERMAL TOXICOLOGY<br />
Chairperson(s): James McDougal, Wright State University, Pharmacology<br />
and <strong>Toxicology</strong>, Dayton, OH and Paul Howard, U.S. FDA, NCTR Biochemical<br />
<strong>Toxicology</strong>, Jefferson, AR.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM–10:00 AM<br />
#2171 DIFFERENTIAL INDUCTION OF<br />
CYCLOOXYGENASE-2 (COX-2) AND HEME<br />
OXYGENASE-1 (HO-1) BY UVB LIGHT IN<br />
GROWING AND CALCIUM-DIFFERENTIATED<br />
PRIMARY CULTURES OF MOUSE<br />
KERATINOCYTES. A. T. Black 1 , M. P. Shakarjian 2 ,<br />
D. R. Gerecke 1,3 , A. M. Vetrano 3 , D. E. Heck 1,3 and J.<br />
D. Laskin 1,4 . 1 Joint Graduate <strong>Program</strong> in <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ, 2 Department <strong>of</strong><br />
Medicine, UMDNJ-Robert W Johnson Med. Sch,<br />
Piscataway, NJ, 3 Pharmacology and <strong>Toxicology</strong>,<br />
Rutgers University, Piscataway, NJ and 4 Environmental<br />
and Occupational Medicine, UMDNJ-Robert W<br />
Johnson Med. Sch, Piscataway, NJ.<br />
#2172 DECREASING MALATHION APPLICATION<br />
TIME FOR LICE TREATMENT REDUCES<br />
TRANSDERMAL ABSORPTION. R. Brand 1,2 , A.<br />
Charron 1 and R. Brand 1,2 . 1 Internal Medicine, Evanston<br />
Northwestern Healthcare, Evanston, IL and 2 Internal<br />
Medicine, Feinberg School <strong>of</strong> Medicine at Northwestern<br />
University, Chicago, IL. Sponsor: P. Iversen.<br />
#2173 DERMAL PENETRATION OF SODIUM LAURYL<br />
SULPHATE AND ITS EFFECT UPON THE<br />
ABSORPTION OF OTHER CHEMICALS IN<br />
VITRO. J. Wakefield 1 , D. Lockley 2 , R. Pendlington 2<br />
and F. Williams 1 . 1 Environmental Medicine, University<br />
<strong>of</strong> Newcastle upon Tyne, Newcastle upon Tyne, United<br />
Kingdom and 2 SEAC, Unilever Colworth, Sharnbrook,<br />
Bedfordshire, United Kingdom.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 215
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2174 INVESTIGATION OF SKIN BARRIER CREAMS<br />
FOR LOWERING PENETRATION OF JP-8 JET<br />
FUEL THROUGH IN VITRO PIG SKIN. J. J.<br />
Schlager 1 , D. L. Pollard 2 , T. A. Minnick 1 , A. J. Guilfoil 1<br />
and S. C. Stevens 1 . 1 HEPB, Applied Biotechnology<br />
Branch, Air Force Research Laboratory, Dayton, OH<br />
and 2 ManTech Environmental Technologies, Inc.,<br />
Dayton, OH.<br />
#2175 EFFECT OF ACUTE AND CHRONIC EXPOSURE<br />
TO THE CLEANSER, TRICHLOROETHYLENE,<br />
ON THE DERMAL ABSORPTION OF THE<br />
BIOCIDE TRIAZINE. J. L. Yeatts, R. E. Baynes, J. D.<br />
Brooks, B. M. Barlow and J. E. Riviere. Center for<br />
Chemical <strong>Toxicology</strong> Research and Pharmacokinetics,<br />
North Carolina State University, Raleigh, NC.<br />
#2176 EFFECT OF IN VIVO JET FUEL EXPOSURE ON<br />
SUBSEQUENT IN VITRO DERMAL<br />
ABSORPTION OF AROMATIC AND ALIPHATIC<br />
HYDROCARBONS. F. Muhammad 1 , N. A. Monteiro-<br />
Riviere 2 , R. E. Baynes 2 and J. E. Riviere 2 . 1 University<br />
<strong>of</strong> Agriculture, Faisalabad, Pakistan and 2 Center for<br />
Chemical <strong>Toxicology</strong> Research and Pharmacokinetics,<br />
North Carolina State University, Raleigh, NC.<br />
#2177 ABSORPTION OF LAWSONE THROUGH<br />
HUMAN SKIN. M. E. Kraeling 1 , C. T. Jung 2 and R. L.<br />
Bronaugh 1 . 1 Office <strong>of</strong> Cosmetics and Colors, U.S. FDA,<br />
Laurel, MD and 2 Office <strong>of</strong> Pharmaceutical Science,<br />
U.S. FDA, Rockville, MD.<br />
#2178 SKIN PENETRATION OF BREAK-FREE CLP IN<br />
THREE SPECIES; SPRAGUE DAWLEY RAT, CD-<br />
1 MOUSE, AND YORKSHIRE PIG. C. M. Garrett<br />
and J. N. McDougal. Pharmacology/<strong>Toxicology</strong>, Wright<br />
State University, Dayton, OH.<br />
#2179 CHANGES IN GENE EXPRESSION IN RAT<br />
EPIDERMIS AFTER JET FUEL (JP-8)<br />
EXPOSURE TO THE SKIN. C. M. Amato, C. M.<br />
Garrett and J. N. McDougal. Pharmacology/<strong>Toxicology</strong>,<br />
Wright State University, Dayton, OH.<br />
#2180 PROTEOMIC ANALYSIS OF JP-8 JET FUEL<br />
EXPOSURE IN HUMAN KERATINOCYTE CELL<br />
CULTURE. F. Witzmann 1 , N. Monteiro-Riviere 2 , A.<br />
Inman 2 , N. Pedrick 1 , H. Ringham 1 and J. Riviere 2 .<br />
1 Cellular & Integrative Physiology, Indiana University<br />
School <strong>of</strong> Medicine, Indianapolis, IN and 2 Center for<br />
Chemical <strong>Toxicology</strong> Research & Pharmacokinetics,<br />
College <strong>of</strong> Veterinary Medicine, North Carolina State<br />
University, Raleigh, NC.<br />
#2181 EXPRESSION PROFILING OF HUMAN<br />
EPIDERMAL KERATINOCYTE RESPONSE<br />
FOLLOWING JP-8 EXPOSURE. C. Chou 1 , J. Yang 2 ,<br />
N. A. Monteiro-Riviere 3 and J. J. Chen 4 . 1 Department <strong>of</strong><br />
Veterinary Medicine, National Chung-Hsing University,<br />
Taichung, Taiwan, 2 Department <strong>of</strong> Dermatology,<br />
Chung-Shan Medical University Hospital, Taichung,<br />
Taiwan, 3 Center for Cutaneous <strong>Toxicology</strong> and<br />
Research Pharmacokinetics, North Carolina State<br />
University, Raleigh, NC and 4 Institute <strong>of</strong> Molecular<br />
Biology, National Chung-Hsing University, Taichung,<br />
Taiwan.<br />
#2182 JP-8 JET FUEL EXPOSURE INDUCES<br />
INFLAMMATORY CYTOKINES IN RAT SKIN. R.<br />
Gallucci 1 , S. K. O’Dell 1 , D. Faulkner 1 and L. D.<br />
Fechter 2 . 1 Pharmaceutical Sciences, OU Health<br />
Sciences Center, Oklahoma City, OK and 2 Jerry Pettis<br />
Memorial Veterans Medical Center, Loma Linds, CA.<br />
#2183 PROTEOMIC ANALYSIS OF NANOPARTICLE<br />
EXPOSURE IN HUMAN KERATINOCYTE CELL<br />
CULTURE. N. A. Monteiro-Riviere 1 , Y. Y. Wang 2 , S.<br />
M. Hong 3 , A. O. Inman 1 , R. J. Nemanich 2 , J. Tan 3 , F. A.<br />
Witzmann 3 and J. E. Riviere 1 . 1 Center for Chemical<br />
<strong>Toxicology</strong> Research and Pharmacokinetics, North<br />
Carolina State University, Raleigh, NC, 2 Department <strong>of</strong><br />
Physics, North Carolina State University, Raleigh, NC<br />
and 3 Department <strong>of</strong> Cellular & Integrative Physiology,<br />
Indiana University School <strong>of</strong> Medicine, Indianapolis,<br />
IN.<br />
#2184 NANTOTUBE DISPERSAL IN HUMAN<br />
KERATINOCYTE CELL CULTURE USING<br />
SURFACTANTS. A. O. Inman 1 , Y. Y. Wang 2 , R. J.<br />
Nemanich 2 , J. E. Riviere 1 and N. A. Monteiro-Riviere 1 .<br />
1 Center for Chemical <strong>Toxicology</strong> Research and<br />
Pharmacokinetics, North Carolina State University,<br />
Raleigh, NC and 2 Department <strong>of</strong> Physics, North<br />
Carolina State University, Raleigh, NC.<br />
#2185 LOCALIZATION OF INTRADERMALLY<br />
INJECTED QUANTUM DOT NANOPARTICLES<br />
IN REGIONAL LYMPH NODES. D. W. Roberts 1 , N.<br />
V. Gopee 1 , B. J. Miller 1 , D. Norton 2 , A. R. Warbritton 2 ,<br />
J. R. Bucher 3 , W. W. Yu 4 , C. M. Sayes 4 , V. L. Colvin 4<br />
and P. C. Howard 1 . 1 Biochemical <strong>Toxicology</strong>, NCTR,<br />
Jefferson, AR, 2 Pathology, Charles River Co., Jefferson,<br />
AR, 3 National <strong>Toxicology</strong> <strong>Program</strong>, NIEHS, Research<br />
Triangle Park, NC and 4 Center for Biological and<br />
Environmental Nanotechnology, Rice University,<br />
Houston, TX.<br />
#2186 IMAGING THE PENETRATION OF RUBPY-<br />
DOPED SILICA NANOPARTICLES INTO<br />
HUMAN AND MOUSE SKIN WITH<br />
FLUORESCENT MICROSCOPY. S. C. Wasdo, S. M.<br />
Roberts, S. Santra, J. Munson and Y. Song. University<br />
<strong>of</strong> Florida, Gainesville, FL.<br />
#2187 MODULATORY EFFECTS OF SUBCHRONIC<br />
EXPOSURE TO SIMULATED SOLAR LIGHT ON<br />
TATTOOED SKIN IN SKH-1 MICE. N. V. Gopee 1,2 ,<br />
Y. Cui 1,2 , G. R. Olson 3 , A. R. Warbritton 3 , B. J.<br />
Miller 1,2 , L. H. Couch 1,2 , W. G. Wamer 4 and P. C.<br />
Howard 1,2 . 1 NCTR, U.S. FDA, Jefferson, AR, 2 NTP<br />
Center for Phototoxicology, NCTR, U.S. FDA,<br />
Jefferson, AR, 3 Charles River Co., Jefferson, AR and<br />
4 CFSAN, U.S. FDA, College Park, MD.<br />
#2188 ROLE OF VITAMIN E IN THE ANTIOXIDANT<br />
DEFENSE SYSTEM OF SKIN IN YOUNG AND<br />
OLD MICE EXPOSED TO CUMENE<br />
HYDROPEROXIDE. A. R. Murray 1 , E. Kisin 2 , K.<br />
Kawai 3 , V. E. Kagan 3 , C. Kommineni 2 , V. Castranova 1,2<br />
and A. A. Shvedova 1,2 . 1 Physiology and Pharmacology,<br />
WVU, Morgantown, WV, 2 PPRB, NIOSH,<br />
Morgantown, WV and 3 University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA.<br />
216<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2189 DETECTION OF BENZO(A)PYRENE-INDUCED<br />
DNA DAMAGE IN THE SKIN OF CD-1 MICE<br />
USING THE COMET ASSAY. J. W. Parton, Y. Xu and<br />
J. K. Kerzee. MicaGenix, Inc., Greenfield, IN.<br />
#2190 EFFECT OF METHYL SUBSTITUTION OF<br />
BENZENE ON THE PERCUTANEOUS<br />
ABSORPTION AND SKIN IRRITATION<br />
HAIRLESS RATS. J. Ramapuram 1 , E. AHAGHOTU 1<br />
and M. SINGH 1 . 1 Florida A&M University, Tallahassee,<br />
FL and 2 SOT, E\TEST, AL.<br />
#2191 LONG TERM REPRODUCIBILITY OF<br />
EPIDERM TM , AN EPIDERMAL MODEL FOR<br />
DERMAL TESTING AND RESEARCH. M.<br />
Klausner, J. Kubilus, J. E. Sheasgreen and P. J. Hayden.<br />
MatTek Corporation, Ashland, MA.<br />
#2192 DETERMINING SKIN IRRITATION POTENTIAL<br />
OF INDUSTRIAL FLUIDS IN HUMANS USING<br />
TRANS-EPIDERMAL WATER LOSS (TEWL). M.<br />
Wragg 1 and S. Signs 2 . 1 Lubrizol Limited, Derby, United<br />
Kingdom and 2 The Lubrizol Corporation, Wickliffe,<br />
OH.<br />
#2193 EVALUATION OF HISTORICAL POSITIVE<br />
CONTROL DATA FOR RESPONSE<br />
CONSISTENCY AND REDUCTION IN ANIMAL<br />
USE IN PHOTOTOXICITY AND<br />
PHOTOALLERGY ASSESSMENTS. D. B. Learn, C.<br />
P. Sambuco, M. Arocena, M. L. Davis, T. S. Coston, P.<br />
D. Forbes and A. M. Hoberman. Center for<br />
Photobiology, Charles River Discovery and<br />
Development Services, Argus Division, Horsham, PA.<br />
#2194 QUANTIFICATION OF MIXTURE<br />
INTERACTIONS ON DERMAL<br />
PERMEABILITY–A SOLVATOCHROMATIC<br />
APPROACH. R. E. Baynes, B. M. Barlow, X. R. Xia,<br />
J. L. Yeatts, J. D. Brooks and J. E. Riviere. Center for<br />
Chemical <strong>Toxicology</strong> Research and Pharmacokinetics,<br />
North Carolina State University, Raleigh, NC.<br />
#2195 PREDICTING HUMAN SKIN ABSORPTION OF<br />
CHEMICALS: DEVELOPMENT OF A NOVEL<br />
QUANTITATIVE STRUCTURE ACTIVITY<br />
RELATIONSHIP. W. Luo 1 , S. Medrek 2 , H. Nguyen 1<br />
and W. Fung 1 . 1 <strong>Toxicology</strong>, L’Oreal USA, Clark, NJ<br />
and 2 Department <strong>of</strong> Chemical Engineering, Princeton<br />
University, Princeton, NJ.<br />
#2196 A NOVEL SYSTEM COEFFICIENT APPROACH<br />
FOR QUANTITATIVE ASSESSMENT OF<br />
DERMAL ABSORPTION FROM CHEMICAL<br />
MIXTURES BY USING THE MEMBRANE-<br />
COATED FIBER TECHNIQUE. X. R. Xia, R. E.<br />
Baynes, N. A. Monteiro-Riviere and J. E. Riviere. Center<br />
for Chemical <strong>Toxicology</strong> Research and<br />
Pharmacokinetics, North Carolina State University,<br />
Raleigh, NC.<br />
#2197 PREDICTION OF DERMAL ABSORPTION OF<br />
CHEMICAL MIXTURES USING BOTH<br />
PENETRANT AND MIXTURE COMPONENT<br />
PROPERTIES IN A HYBRID QUANTITATIVE<br />
STRUCTURE PERMEABILITY RELATIONSHIP<br />
(QSPR). J. E. Riviere and J. D. Brooks. Center for<br />
Chemical <strong>Toxicology</strong> Research and Pharmacokinetics,<br />
North Carolina State University, Raleigh, NC.<br />
#2198 COMPUTER-CONTROLLED SYSTEM FOR<br />
GENERATION OF CHEMICAL VAPORS IN IN<br />
VITRO DERMAL UPTAKE STUDIES. M. Rauma<br />
and G. Johanson. Work Environment <strong>Toxicology</strong>,<br />
Karolinska Institutet, Stockholm, Sweden.<br />
#2199 CAN CHRONIC SKIN IRRITATION BE<br />
PREDICTED BY AN ACUTE TEST? C. M. de<br />
Jongh, J. J. Jacobs, S. Kezic and M. M. Verberk.<br />
Coronel Institute for Occupational and Environmental<br />
Health, AMC, University <strong>of</strong> Amsterdam, Amsterdam,<br />
Netherlands. Sponsor: P. Boogaard.<br />
#2200 ANTI-PSORIASIS MODEL IN THE MOUSE. S.<br />
Rowton and P. Long. Covance Laboratories Ltd.,<br />
Harrogate, United Kingdom. Sponsor: D. Everett.<br />
#2201 EVALUATION OF THE TOXICITY OF MEDICAL<br />
COUNTERMEASURES FOR SULFUR MUSTARD.<br />
D. M. Moore 1 , R. C. Kiser 1 , N. A. Niemuth 1 , B. M.<br />
Biddle 1 , M. C. Babin 1 , I. Koplovitz 2 and W. J. Smith 2 .<br />
1 2 Battelle Memorial Institute, Columbus, OH and US<br />
Army Medical Reasearch Institute <strong>of</strong> Chemical<br />
Defense, Aberdeen, MD.<br />
#2202 MOUSE EAR VESICANT MODEL (MEVM)<br />
EVALUATION OF TREATMENT<br />
COMBINATIONS AGAINST TOPICAL SULFUR<br />
MUSTARD CHALLENGE. R. C. Kiser 1 , D. M.<br />
Moore 1 , N. A. Niemuth 1 , B. M. Biddle 1 , M. C. Babin 1 ,<br />
R. P. Casillas 1 , I. Koplovitz 2 and W. J. Smith 2 . 1 Battelle<br />
Memorial Institute, Columbus, OH and 2 US Army<br />
Medical Research Institute <strong>of</strong> Chemical Defense,<br />
Aberdeen, MD.<br />
#2203 90-DAY SUBCHRONIC DERMAL TOXICITY OF<br />
INSECT REPELLENT SS-220I IN RATS. J. T.<br />
Houpt and G. J. Leach. US Army Center for Health<br />
Promotion and Preventive Medicine, Aberdeen Proving<br />
Ground, MD.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: GENOTOXICITY<br />
Chairperson(s): Martha M. Moore, U.S. FDA, Jefferson, AR.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 10:00 AM–11:30 AM<br />
#2204 DATABASE CONSOLIDATION BASED ON<br />
TOXML OF GENETIC TOXICITY DATA<br />
SUBMITTED TO CFSAN/OFAS AND CDER. J.<br />
Mayer 1 , M. Cheeseman 1 , C. Nelson 1 , R. Benz 2 , E.<br />
Matthews 2 , N. Kruhlak 2 , J. Contrera 2 , M. Twaroski 1 , K.<br />
Arvidson 1 and C. Yang 3 . 1 CFSAN/OFAS, U.S. FDA,<br />
College Park, MD, 2 CDER/OPS/ICSAS, U.S. FDA,<br />
Rockville, MD and 3 Leadscope, Inc., Columbus, OH.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 217
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2205 INTER-LABORATORY EVALUATION OF<br />
BIOLUMINESCENT SALMONELLA REVERSE<br />
MUTATION ASSAY USING TEN (10) MODEL<br />
CHEMICALS. J. I. Ackerman 1 , T. Hayashi 2 , J.<br />
Hitchcock 3 , L. Li 4 , S. Lu 4 , Y. Nagai 2 , F. Spence 3 and J.<br />
Aubrecht 1 . 1 Safety Sciences, Pfizer Inc., Groton, CT,<br />
2 3 Safety Sciences, Pfizer Inc., Nagoya, Japan, Safety<br />
Sciences, Pfizer Inc., Sandwich, United Kingdom,<br />
4 5 Safety Sciences, Pfizer Inc., La Jolla, CA, Safety<br />
Sciences, Pfizer Inc., La Jolla, CA, 6 Safety Sciences,<br />
Pfizer Inc., Nagoya, Japan, 7 Safety Sciences, Pfizer Inc.,<br />
Sandwich, United Kingdom and 8 Safety Sciences,<br />
Pfizer Inc., Groton, CT.<br />
#2206 MEASUREMENT OF MUTANT FREQUENCY IN<br />
T-CELL RECEPTOR GENE BY FLOW<br />
CYTOMETRY ON EL-4 MOUSE LYMPHOMA<br />
CELLS. N. Kunugita 1 , N. Mei 2,3 , T. Goncharova 2 and<br />
T. Norimura 2 . 1 School <strong>of</strong> Health Sciences, University <strong>of</strong><br />
Occupational and Environmental Health, Kitakyushu,<br />
Japan, 2 Department <strong>of</strong> Radiation Biology & Health,<br />
University <strong>of</strong> Occupational and Environmental Health,<br />
Kitakyushu and 3 NCTR, Jefferson, AR.<br />
#2207 A HIGH-THROUGHPUT UNSCHEDULED DNA<br />
SYNTHESIS (UDS) ASSAY USING FLOW<br />
CYTOMETRY. C. A. Kirk, D. R. Cerven and G. L.<br />
DeGeorge. MB Research Laboratories, Spinnerstown,<br />
PA.<br />
#2208 MODIFIED BACTERIAL MUTATION TEST<br />
PROCEDURES FOR EVALUATION OF<br />
PEPTIDES AND AMINO ACID-CONTAINING<br />
MATERIAL. C. Thompson. <strong>Toxicology</strong>, CTBR,<br />
Senneville, QC, Canada. Sponsor: C. Banks.<br />
#2209 DEVELOPMENT OF A NOVEL MICRONUCLEUS<br />
ASSAY USING THE HUMAN 3-D SKIN MODEL,<br />
EPIDERM R. D. Curren 1 , G. Mun 1 , D. P. Gibson 2<br />
and M. J. Aardema 2 . 1 Institute for In Vitro Sciences,<br />
Inc., Gaithersburg, MD and 2 Procter & Gamble Co.,<br />
Cincinnati, OH.<br />
#2210 INCREASED MICRONUCLEI FOLLOWING<br />
OXYMORPHONE ADMINISTRATION ARE<br />
SECONDARY TO INCREASED BODY<br />
TEMPERATURE. D. Shuey 1 , R. Gudi 2 , L.<br />
Krsmanovic 2 and R. Gerson 1 . 1 Endo Pharmaceuticals<br />
Inc., Chadds Ford, PA and 2 BioReliance, Rockville,<br />
MD.<br />
#2211 THE CONTRIBUTION OF NON-CHEMICALLY<br />
INDUCED HYPOTHERMIA IN THE<br />
FORMATION OF MICRONUCLEI (MN) IN THE<br />
MOUSE BONE MARROW MICRONUCLEUS<br />
TEST (MNT). P. J. Spencer, J. G. Grundy, J. M.<br />
Waechter and B. Gollapudi. <strong>Toxicology</strong> &<br />
Environmental Research and Consulting, The Dow<br />
Chemical Company, Midland, MI.<br />
#2212 IN VITRO MICRONUCLEUS SCORING BY<br />
FLOW CYTOMETRY: DIFFERENTIAL<br />
STAINING OF MICRONUCLEI AND APOPTOTIC<br />
CHROMATIN ENHANCES ASSAY RELIABILITY.<br />
S. D. Dertinger, S. Avlasevich, S. Cairns and D. K.<br />
Torous. Litron Laboratories, Rochester, NY.<br />
#2213 ESTABLISHMENT OF HUMANIZED IN VITRO<br />
GENOTOXICITY TEST SYSTEM. M. Honma 1 , A.<br />
Hakura 2 , H. Oka 3 , W. Takasaki 4 , Y. F. Sasaki 5 , S.<br />
Suzuki 6 and T. Sato 6 . 1 National Institute <strong>of</strong> Health<br />
Sciences, Tokyo, Japan, 2 Eisai Co.Ltd.,, Gifu, Japan,<br />
3 Taiho Pharmacology Co.Ltd.,, Tokushima, Japan,<br />
4 5 Sankyo Co.Ltd.,, Shizuoka, Japan, Hachinohe NCT,<br />
Aomori, Japan and 6 HAB Bio Res Inst, Chiba, Japan.<br />
#2214 DIFFERENTIAL S-9 ACTIVATION OF<br />
HYDROCODONE BITARTRATE AND<br />
NALTREXONE HYDROCHLORIDE WITH<br />
HUMAN LIVER S-9 AND RAT LIVER S-9 IN THE<br />
MOUSE LYMPHOMA FORWARD MUTATION<br />
ASSAY. K. W. Hew 1 , M. A. Cifone 2 and T. Lawal 2 .<br />
1 2 Purdue Pharmacology L.P., Ardsley, NY and Covance<br />
Laboratories Inc., Vienna, VA.<br />
#2215 APPLICATION OF HUMAN EXOGENOUS<br />
METABOLIC SYSTEM IN GENOTOXICITY<br />
EVALUATION. A. P. LI 2,1,3 , S. K. Roy 3 , C. Bode 4 , P.<br />
Kirby 2,3 and A. Thilagar 2,3 . 1 Advanced Pharmaceutical<br />
Sciences, Columbia, MD, 2 The ADMET Group LLC,<br />
Rockville, MD, 3 Sitek Laboratories Inc., Rockville, MD<br />
and 4 Tissue Transformation Technologies, Inc., Edison,<br />
NJ.<br />
#2216 MOLECULAR ANALYSIS OF SPONTANEOUS<br />
AND 3’-AZIDO-3’-DEOXYTHYMIDINE-<br />
INDUCED L5178Y TK -/- MOUSE LYMPHOMA<br />
CELL MUTANTS. J. Wang 1,2 , L. Chen 1,3 , T. Chen 1<br />
and M. M. Moore 1,2 . 1 DGRT, NCTR, Jefferson, AR,<br />
2 Department <strong>of</strong> Pharmacology and <strong>Toxicology</strong>,<br />
University <strong>of</strong> Arkansas for Medical Sciences, Little<br />
Rock, AR and 3 College <strong>of</strong> Life Science and Technology,<br />
Shanghai Jiao Tong University, Shanghai, China.<br />
#2217 GENOTOXIC EFFECTS OF 4-<br />
HYDROXYNONENAL TRIACETATE, A<br />
CHEMICALLY PROTECTED FORM OF THE<br />
LIPID PEROXIDATION PRODUCT 4-<br />
HYDROXYNONENAL, AS ASSAYED IN L5178Y<br />
MOUSE LYMPHOMA CELLS. S. P. Singh 1 , L.<br />
Chen 3 , N. Mei 2 , T. Chen 2 , E. McLain 1 , V. Samokyszyn 1 ,<br />
M. Moore 2 and P. Zimniak 1 . 1 <strong>Toxicology</strong>, UAMS, Little<br />
Rock, AR, 2 Genetic and Reproductive <strong>Toxicology</strong>,<br />
NCTR, Jefferson, AR and 3 College <strong>of</strong> Life Sciences,<br />
Shanghai Jiao Tong University, Shanghai, China.<br />
#2218 PHOTOMUTAGENICITY OF RETINYL<br />
PALMITATE AND ANHYDRORETINOL IN<br />
MOUSE LYMPHOMA CELLS. N. Mei 1 , Q. Xia 2 , L.<br />
Chen 1 , P. P. Fu 2 , M. M. Moore 1 and T. Chen 1 . 1 Division<br />
<strong>of</strong> Genetic and Reproductive <strong>Toxicology</strong>, NCTR/FDA,<br />
Jefferson, AR and 2 Division <strong>of</strong> Biochemical <strong>Toxicology</strong>,<br />
NCTR/FDA, Jefferson, AR.<br />
#2219 GENETIC TOXICOLOGICAL STUDIES FOR<br />
LUPINUS TERMIS ALCOHOLIC EXTRACT. M.<br />
R. Santiago 1 , Z. Ramos 2 , I. Oquendo 2 , M. Antoun 2 and<br />
D. Herreno-Saenz 1 . 1 Pharmacology and <strong>Toxicology</strong>,<br />
School <strong>of</strong> Medicine, University <strong>of</strong> Puerto Rico, San<br />
Juan, Puerto Rico and 2 School <strong>of</strong> Pharmacy, University<br />
<strong>of</strong> Puerto Rico, San Juan, Puerto Rico.<br />
218<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2220 TAXOL INDUCES MUTATIONS IN THE TK<br />
GENE OF L5178Y/TK+/- MOUSE LYMPHOMA<br />
CELLS THROUGH A MITOTIC NON-<br />
DISJUNCTION MECHANISM. M. M. Moore, N.<br />
Mei, L. Chen and T. Chen. Division <strong>of</strong> Genetic and<br />
Reproductive <strong>Toxicology</strong>, NCTR/FDA, Jefferson, AR.<br />
#2221 INCREASED GERMLINE MUTATION<br />
FREQUENCIES INDUCED BY ETHYLENE<br />
DICHLORIDE IN MALE MICE. H. J. Daigle and V.<br />
L. Wilson. Biological Science, Louisiana State<br />
University, Baton Rouge, LA.<br />
#2222 MICROARRAY GENE EXPRESSION ANALYSIS<br />
REVEALS DIFFERENCES BETWEEN LARGE<br />
AND SMALL COLONY THYMIDINE KINASE<br />
MUTANTS OF L5178Y MOUSE LYMPHOMA<br />
CELLS. T. Han 1,2 , J. Wang 3 , T. Chen 3 , J. C. Fuscoe 1,2<br />
and M. M. Martha 3 . 1 Center for Functional Genomics,<br />
NCTR/U.S. FDA, Jefferson, AR, 2 Division <strong>of</strong> Systems<br />
<strong>Toxicology</strong>, NCTR/U.S. FDA, Jefferson, AR and<br />
3 Division <strong>of</strong> Genetic and Reproductive <strong>Toxicology</strong>,<br />
NCTR/U.S. FDA, Jefferson, AR.<br />
#2223 MICRONUCLEUS INDUCTION AND DNA<br />
DAMAGE IN V 79 CELLS IN VITRO BY DUSTS<br />
FROM HARD METAL SINTERING AND<br />
DETONATION COATING PROCESSES. M. J.<br />
Keane and W. E. Wallace. Health Eff. Lab. Division,<br />
NIOSH, Morgantown, WV.<br />
#2224 TRICHLROETHYLENE (TCE) INHALATION<br />
DID NOT INDUCE CYTOGENETIC DAMAGE IN<br />
THE RAT BONE MARROW MICRONUCLEUS<br />
TEST (MNT). J. W. Wilmer, P. J. Spencer, J. G.<br />
Grundy, V. A. Linscombe, S. M. Krieger and B.<br />
Gollapudi. <strong>Toxicology</strong> & Environmental Research and<br />
Consulting, The Dow Chemical Company, Midland, MI.<br />
#2225 ABILITY OF ALKYLTIN COMPOUNDS TO<br />
PENETRATE CELL MEMBRANES AND ITS<br />
RELATION TO INDUCTION OF GENOTOXIC<br />
EFFECTS IN CHINESE HAMSTER OVARY<br />
(CHO) CELLS. E. Dopp 1 , A. M. Florea 1 , L. M.<br />
Hartmann 2 , B. Shokouhi 1 , U. von Recklinghausen 1 , A.<br />
V. Hirner 2 and A. W. Rettenmeier 1 . 1 Institute <strong>of</strong><br />
Hygiene and Occupational Medicine, University <strong>of</strong><br />
Duisburg-Essen, Essen, NRW, Germany and 2 Institute<br />
<strong>of</strong> Environmental Chemistry, University <strong>of</strong> Duisburg-<br />
Essen, Essen, Germany. Sponsor: E. Nelson.<br />
#2226 RAT ERYTHROCYTE MICRONUCLEUS TEST:<br />
ROLE OF ERYTHROPOIESIS AND EFFECT OF<br />
CIGARETTE MAINSTREAM SMOKE. E. Van<br />
Miert and P. Vanscheeuwijck. PHILIP MORRIS<br />
Research Laboratories bvba, Leuven, Belgium. Sponsor:<br />
H. Haussmann.<br />
#2227 THE EFFECT OF BREVENAL ON DNA DAMAGE<br />
IN HUMAN LYMPHOCYTES INDUCED BY<br />
BREVETOXINS 2 AND 3 (PBTX-2 OR 3). J. E.<br />
Gibson 1,4 , A. N. Sayer 4,1 , A. J. Bourdelais 2 and D. G.<br />
Baden 2,3 . 1 Pharmacology and <strong>Toxicology</strong>, The Brody<br />
School <strong>of</strong> Medicine at East Carolina University,<br />
Greenville, NC, 2 Center for Marine Science, University<br />
<strong>of</strong> North Carolina at Wilmington, Wilmington, NC,<br />
3 Chemistry, University <strong>of</strong> North Carolina at<br />
Wilmington, Wilmington, NC and 4 Biology, East<br />
Carolina University, Greenville, OR.<br />
#2228 BISPHENOL A-INDUCED DNA DAMAGE IN<br />
C57BL/6N MICE: PRACTICAL IN VIVO<br />
APPLICATIONS OF THE COMET ASSAY. Y. Xu, J.<br />
W. Parton and J. K. Kerzee. MicaGenix, Inc.,<br />
Greenfield, IN.<br />
#2229 THE EFFECT OF PUFF VOLUME ON THE<br />
SPECIFIC ACTIVITY OF CIGARETTE SMOKE<br />
CONDENSATE AS MEASURED IN THE AMES<br />
ASSAY. R. Leverette, M. B. Bennett, J. T. Hamm, M.<br />
Misra, S. V. Vulimiri and S. F. Yee. Lorillard,<br />
Greensboro, NC.<br />
#2230 GENOTOXICITY PROFILES OF COMMON<br />
ALKYL HALIDES AND ALKYL ESTERS. J. J.<br />
Osowski 1 , M. E. Masucci 1 , Z. Kirpnick 2 , E. E.<br />
Rubitski 1 , J. K. Cheung 1 , J. I. Ackerman 1 , W. W. Ku 1 , R.<br />
H. Schiestl 2 and J. Aubrecht 1 . 1 Safety Sciences, Pfizer,<br />
Inc., Groton, CT and 2 Departments <strong>of</strong> Pathology,<br />
Environmental Health and Radiation Oncology, Geffen<br />
School <strong>of</strong> Medicine and School <strong>of</strong> Public Health,<br />
UCLA, Los Angeles, CA.<br />
#2231 DETECTING ANTHRACYCLINE-INDUCED<br />
INTRACHROMOSOMAL RECOMINBINATION<br />
IN SACCHAROMYCES CEREVISIAE USING A<br />
DEL ASSAY. J. Armagost and W. J. Mackay. Biology,<br />
Edinboro University, Edinboro, PA.<br />
#2232 CARCINOGENIC CR(VI) AND THE<br />
NUTRITIONAL SUPPLEMENT CR(III) INDUCE<br />
DNA DELETIONS IN YEAST AND MICE. Z.<br />
Kirpnick, R. Reliene, N. Carls and R. H. Schiestl.<br />
Pathology, David Geffen School <strong>of</strong> Medicine at UCLA,<br />
Los Angeles, CA.<br />
#2233 YEAST DEL ASSAY DETECTS CLASTOGENS. E.<br />
E. Rubitski 1 , Z. Kirpnick 2 , M. Homiski 1 , M.<br />
Repnevskaya 2 , N. Howlett 3 , R. H. Schiestl 2 and J.<br />
Aubrecht 1 . 1 Safety Sciences, Pfizer, Inc., Groton, CT,<br />
2 Departments <strong>of</strong> Pathology, Environmental Health and<br />
Radiation Oncology, Geffen School <strong>of</strong> Medicine and<br />
School <strong>of</strong> Public Health, UCLA, Los Angeles, CA and<br />
3 Department <strong>of</strong> Pediatric Oncology, Dana-Farber<br />
Cancer Institute, Boston, MA.<br />
#2234 NUCLEAR LOCALISATION AND DNA REPAIR<br />
CAPACITY OF HOGG1 VARIANTS<br />
POLYMORPHIC AT RESIDUE 326 FOLLOWING<br />
TRANSFECTION OF OGG1 -/- NULL MOUSE<br />
FIBROBLASTS. D. Smart, N. Hodges and K.<br />
Chipman. School <strong>of</strong> Biosciences, The University <strong>of</strong><br />
Birmingham, Birmingham, United Kingdom. Sponsor:<br />
T. Hammond.<br />
#2235 A COMPARATIVE STUDY OF UVB AND UVC<br />
MUTAGENESIS IN DNA REPAIR PROFICIENT<br />
AND MISMATCH REPAIR DEFICIENT (PMS2)<br />
MOUSE CELLS. A. Skinner 2,1 , C. Shin-Darlak 1,2 and<br />
M. Turker 1,2 . 1 Center for Research on Occupational and<br />
Environmental <strong>Toxicology</strong>, Oregon Health and Sciences<br />
University, Portland, OR and 2 Environmental and<br />
Molecular <strong>Toxicology</strong>, Oregon State University,<br />
Corvallis, OR.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 219
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2236 MODULATION OF NNK-INDUCED GENETIC<br />
DAMAGE BY POLYMORPHISM IN THE BASE<br />
EXCISION REPAIR GENE APE1 IN SMOKERS. K.<br />
Wolfe, A. A. Affatato, C. E. Hill, J. K. Wickliffe and S.<br />
Z. Abdel-Rahman. University <strong>of</strong> Texas Medical Branch,<br />
Galveston, TX.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: DEVELOPMENTAL TOXICOLOGY<br />
MECHANISMS<br />
Chairperson(s): Asok Dasmahapatra, University <strong>of</strong> Mississippi, University,<br />
MS and Mary Haasch, University <strong>of</strong> Mississippi, University, MS.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM-10:00 AM<br />
#2237 THE MECHANISMS OF DITHIOCARBAMATE<br />
DEVELOPMENTAL TOXICITY. F. Tilton 1,2,3 and R.<br />
L. Tanguay 1,2,3 . 1 Environmental and Molecular<br />
<strong>Toxicology</strong>, Oregon State University, Corvallis, OR,<br />
2 Marine & Freshwater Biomedical Sciences Center,<br />
Oregon State University, Corvallis, OR and<br />
3 Environmental Health Sciences Center, Oregon State<br />
University, Corvallis, OR.<br />
#2238 TCDD ALTERS GENE EXPRESSION IN<br />
ZEBRAFISH OVARY: INSIGHT INTO THE<br />
MECHANISMS BY WHICH TCDD IMPACTS<br />
REPRODUCTION IN FISH. T. King Heiden 1,2 , M.<br />
Rise 1 , M. Hessner 3 , R. Hutz 1,2 and M. J. Carvan 1 . 1 UW-<br />
Milwaukee Great Lakes WATER Inst, Milwaukee, WI,<br />
2 Biological Sciences, UW-Milwaukee, Milwaukee, WI<br />
and 3 Pediatrics, Medical College <strong>of</strong> Wisconsin,<br />
Milwaukee, WI.<br />
#2239 MATRIX METALLOPROTEINASE INHIBITION<br />
DURING ZEBRAFISH EMBRYOGENESIS<br />
FOLLOWING EXPOSURE TO<br />
HYDROCORTISONE AND DEXAMETHASONE. J.<br />
M. Hillegass, C. M. Villano, L. A. White and K. R.<br />
Cooper. Biochemistry & Microbiology, Rutgers, The<br />
State University <strong>of</strong> New Jersey, New Brunswick, NJ.<br />
#2240 EARLY EMBRYONIC RESPONSES OF<br />
ZEBRAFISH TO DIESEL PARTICULATE<br />
MATTER. M. D. Smith, S. J. D’Surney, V. Tillis, E.<br />
Johnson and E. Eiland. Biology, University <strong>of</strong><br />
Mississippi, University, MS.<br />
#2241 ARYL HYDROCARBON RECEPTOR (AHR)<br />
ACTIVATION INHIBITS ZEBRAFISH EARLY<br />
LIFE STAGE CAUDAL FIN REGENERATION. L.<br />
K. Mathew, E. A. Andreasen and R. L. Tanguay.<br />
Environmental and Molecular <strong>Toxicology</strong>, The<br />
Environmental Health Sciences Center, and The Marine<br />
and Freshwater Biomedical Sciences Center, Oregon<br />
State University, Corvallis, OR.<br />
#2242 TCDD IMPAIRS EXTRACELLULAR MATRIX<br />
REMODELING IN THE REGENERATING<br />
ZEBRAFISH CAUDAL FIN. E. A. Andreasen, J. M.<br />
Zodrow, L. K. Mathew, R. Hasson and R. L. Tanguay.<br />
Environmental and Molecular <strong>Toxicology</strong> The<br />
Environmental Health Sciences Center, and The Marine<br />
Freshwater Biomedical Sciences Center, Oregon State<br />
University, Corvallis, OR.<br />
#2243 ETHANOL- AND ACETALDEHYDE-MEDIATED<br />
DEVELOPMENTAL TOXICITY IN ZEBRAFISH.<br />
M. Reimers, J. La Du, A. Flockton and R. Tanguay.<br />
Department <strong>of</strong> Environmental and Molecular<br />
<strong>Toxicology</strong>, The Environmental Health Sciences Center,<br />
and The Marine/Freshwater Biomedical Sciences Center,<br />
Oregon State University, Corvallis, OR.<br />
#2244 EFFECTS OF ETOPOSIDE ON HUMAN FETAL<br />
HEMATOPOIETIC STEM CELLS. C. G.<br />
Moneypenny, P. L. Stapleton and E. P. Gallagher.<br />
Environmental and Occupational Health Sciences,<br />
University <strong>of</strong> Washington, Seattle, WA.<br />
#2245 DOSE-DEPENDENT SURVIVAL DIFFERENCES<br />
IN CHICKENS DEVELOPMENTALLY CO-<br />
EXPOSED TO NEAR-INFRARED LIGHT<br />
THERAPY AND DIOXIN. R. L. Yeager 1 , J. A.<br />
Franzosa 1 , D. S. Millsap 1 , J. T. Eells 2 , H. T. Whelan 3<br />
and D. S. Henshel 1 . 1 School <strong>of</strong> Public and<br />
Environmental Affairs, Indiana University,<br />
Bloomington, IN, 2 Department <strong>of</strong> Health Science,<br />
University <strong>of</strong> Wisconsin-Milwaukee, Milwaukee, WI<br />
and 3 Department <strong>of</strong> Neurology, Medical College <strong>of</strong><br />
Wisconsin, Milwaukee, WI.<br />
#2246 ALTERATION OF NORMAL CARDIAC<br />
DEVELOPMENT BY TRICHLOROETHYLENE<br />
AND ITS METABOLITE TRICHLOROACETIC<br />
ACID. V. J. Drake 1 , S. L. Koprowski 2 , J. W. Lough 2 and<br />
S. M. Smith 1 . 1 Nutritional Sciences, University <strong>of</strong><br />
Wisconsin-Madison, Madison, WI and 2 Cell Biology,<br />
Anatomy and Neurobiology, Medical College <strong>of</strong><br />
Wisconsin, Milwaukee, WI. Sponsor: R. Hines.<br />
#2247 TOXICOGENOMICS IN MALFORMATIONS<br />
INDUCED BY FUNGICIDE FLUCONAZOLE. C. L.<br />
Galli 1 , E. Menegola 2 , E. Giavini 2 , E. Corsini 1 and M.<br />
Marinovich 1 . 1 Department.Pharmacological Sciences,<br />
University <strong>of</strong> Milan, Milan, Italy and 2 Department <strong>of</strong><br />
Biology, University <strong>of</strong> Milan, Milan, Italy.<br />
#2248 RELATIVE POTENCIES OF SELECTED<br />
DIHALOACETIC ACIDS AND THEIR MAJOR<br />
METABOLITES IN MOUSE WHOLE EMBRYO<br />
CULTURE. S. Hunter, M. Blanton and E. Rogers. RTD,<br />
NHEERL, ORD, U.S. EPA, Research Triangle Park,<br />
NC. Sponsor: J. Rogers.<br />
#2249 EVALUATION OF GLYCOLIC ACID IN RABBIT<br />
WHOLE EMBRYO CULTURE. E. W. Carney, B.<br />
Tornesi and N. Moore. <strong>Toxicology</strong> & Environmental<br />
Research and Consulting, The Dow Chemical Company,<br />
Midland, MI.<br />
220<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2250 ENDOGENOUS EMBRYONIC CATALASE<br />
ACTIVITY DURING ORGANOGENESIS IN<br />
EMBRYO CULTURE, IN VIVO AND AFTER<br />
EXPOSURE TO PHENYTOIN-ENHANCED<br />
OXIDATIVE STRESS. J. Perstin 1 and P. G. Wells 1,2 .<br />
1 Faculty <strong>of</strong> Pharmacy, University <strong>of</strong> Toronto, Toronto,<br />
ON, Canada and 2 Department <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Toronto, Toronto, ON, Canada.<br />
#2251 IN VITRO STUDY ON THE EMBRYOTOXIC<br />
POTENTIAL OF N-METHYL-PYRROLIDONE<br />
(NMP) AND ITS METABOLITES. B. Flick 1 , R.<br />
Jaeckh 2 and S. Klug 1 . 1 Institute <strong>of</strong> Clinical<br />
Pharmacology and <strong>Toxicology</strong>, Berlin, Germany and<br />
2 BASF AG, Ludwigshafen, Germany. Sponsor: J.<br />
Sherman.<br />
#2252 IN VITRO STUDY ON THE EMBRYOTOXIC<br />
POTENTIAL OF BRANCHED-CHAIN<br />
CARBOXYLIC ACIDS. B. Flick 1 , R. Jaeckh 2 and S.<br />
Klug 1 . 1 Institute <strong>of</strong> Clinical Pharmacolgoy and<br />
<strong>Toxicology</strong>, Berlin, Germany and 2 BASF AG,<br />
Ludwigshafen, Germany. Sponsor: J. Sherman.<br />
#2253 CHARACTERIZATION OF ALCOHOL<br />
METABOLIZING ENZYMES IN JAPANESE<br />
MEDAKA. X. Wang 2,1 , E. S. Williams 2,1 , M. L.<br />
Haasch 1,2 and A. K. Dasmahapatra 1,2 . 1 Environmental<br />
<strong>Toxicology</strong> Research <strong>Program</strong>, NCNPR, RIPS,<br />
University <strong>of</strong> Mississippi, University, MS and<br />
2 Department <strong>of</strong> Pharmacology, University <strong>of</strong><br />
Mississippi, University, MS.<br />
#2254 VISUALIZATION OF TISSUE DISTRIBUTION<br />
AND METABOLISM OF BENZO(A)PYRENE IN<br />
EMBRYONIC MEDAKA (ORYZIAS LATIPES). M.<br />
W. Hornung, R. D. Johnson, P. M. Cook and J. W.<br />
Nichols. NHEERL, MED, U.S. EPA, Duluth, MN.<br />
#2255 PFOA INDUCES DYSMORPHOGENESIS IN<br />
MOUSE WHOLE EMBRYO CULTURE. M. R.<br />
Blanton 1 , J. M. Padowski 2 , S. S. Hunter 1 , J. M. Rogers 1<br />
and C. Lau 1 . 1 RTD, NHEERL, ORD, U.S. EPA,<br />
Research Triangle Park, NC and 2 Curriculum in<br />
<strong>Toxicology</strong>, UNC, Chapel Hill, NC.<br />
#2256 THALIDOMIDE DEPLETES GLUTATHIONE<br />
AND INITIATES OXIDATIVE STRESS IN RAT<br />
NEURAL CREST CELLS. C. Harris and P. A.<br />
Paximadis. Environmental Health Sciences, University<br />
<strong>of</strong> Michigan, Ann Arbor, MI.<br />
#2257 EXAMINATION OF METAL-INDUCED CELL<br />
CYCLE ALTERATIONS AND APOPTOSIS IN<br />
C57BL/6 AND SWV MOUSE EMBRYONIC<br />
FIBROBLASTS. J. F. Robinson, X. Yu, J. S. Sidhu, S.<br />
Hong, E. Kim and E. M. Faustman. Environmental and<br />
Occupational Health Sciences, University <strong>of</strong><br />
Washington, Seattle, WA.<br />
#2258 IDENTIFICATION OF GENE CLUSTERS AND<br />
SIGNALLING PATHWAYS AFFECTED BY<br />
DIBUTYL PHTHALATE–NUCLEAR RECEPTOR<br />
INTERACTIONS IN FOETAL RAT TESTES. S.<br />
Plummer 1 , N. Hallmark 2 , R. Sharpe 2 and C. Elcombe 1 .<br />
1 CXR Biosciences Ltd., Dundee, United Kingdom and<br />
2 MRC Human Reproductive Sciences Unit, Edinburgh,<br />
United Kingdom.<br />
#2259 VALPROIC ACID INCREASES CONSERVATIVE<br />
HOMOLOGOUS RECOMBINATION<br />
FREQUENCY: IMPLICATIONS FOR A<br />
MECHANISM OF VALPROIC ACID-INDUCED<br />
NEURAL TUBE DEFECTS. E. Defoort 1 , P. M. Kim 1<br />
and L. M. Winn 1,2 . 1 Pharmacology and <strong>Toxicology</strong>,<br />
Queen’s University, Kingston, ON, Canada and 2 School<br />
<strong>of</strong> Environmental Studies, Queen’s University, Kingston,<br />
ON, Canada.<br />
#2260 TERATOGENIC EFFECTS OF FORSKOLIN,<br />
CYCLOPAMINE AND ETHANOL ON EARLY<br />
BRAIN AND EYE DEVELOPMENT. E. Loucks and<br />
S. Ahlgren. Childrens Memorial Research Center,<br />
Chicago, IL.<br />
#2261 PROTECTION AGAINST MNU-INDUCED FETAL<br />
MALFORMATIONS AND PLACENTAL<br />
MALDEVELOPMENT WITH DIETARY<br />
BUTYLATED HYDROXYTOLUENE<br />
SUPPLEMENTATION. M. R. Prater 1,2 , L. Pinn 2 , J.<br />
Keay 2 and S. D. Holladay 2 . 1 Biomedical Sciences,<br />
Edward Via Virginia College <strong>of</strong> Osteopathic Medicine,<br />
Blacksburg, VA and 2 Biomedical Sciences and<br />
Pathobiology, Virginia-Maryland Regional College <strong>of</strong><br />
Veterinary Medicine, Virginia Tech, Blacksburg, VA.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: DNA AND PROTEIN ADDUCTS<br />
Chairperson(s): Scott W. Burchiel, University <strong>of</strong> New Mexico, Albuquerque,<br />
NM and Judy L. Bolton, University <strong>of</strong> Illinois, Chicago, IL.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 10:00 AM-11:30 AM<br />
#2262 N1- AND N7-DEOXYGUANOSINE ADDUCTS OF<br />
DIEPOXYBUTANE EXHIBIT DIFFERENT<br />
STABILITIES AND DECOMPOSITION<br />
PATTERNS UNDER PHYSIOLOGICAL<br />
CONDITIONS. X. Zhang and A. A. Elfarra.<br />
Department <strong>of</strong> Comparative Biosciences, University <strong>of</strong><br />
Wisconsin-Madison, Madison, WI.<br />
#2263 DEPURINATION OF NUCLEOSIDES INDUCED<br />
BY HALOGENATED ALKANES IN THE<br />
PHYSIOLOGICAL CONDITION. J. Kim, J.<br />
Sherchan, B. Arjun, B. Choi, E. Kim, Y. Jahng, T. Jeong<br />
and E. Lee. College <strong>of</strong> Pharmacy, Yeungnam University,<br />
Kyongsan, Kyongbuk, South Korea.<br />
#2264 EXPOSURE-BASED SAFETY ASSESSMENT OF<br />
THE NATURALLY OCCURRING FLAVOURING<br />
METHYL EUGENOL. J. Ellis 1 , P. L. Carmichael 2,1<br />
and N. J. Gooderham 1 . 1 Biological Chemistry, Imperial<br />
College London, London, United Kingdom and<br />
2 SEAC–Safety and Environmental Assurance, Unilever,<br />
Sharnbrook, United Kingdom.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 221
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2265 DETECTION OF ELEVATED 8-<br />
HYDROXYDEOXYGUANOSINE IN FRESHLY<br />
ISOLATED MOUSE LUNG CELLS FOLLOWING<br />
IN VIVO TREATMENT WITH AFLATOXIN B 1 K.<br />
A. Guindon, S. L. Graham, L. L. Bedard and T. E.<br />
Massey. Pharmacology and <strong>Toxicology</strong>, Queen,<br />
Kingston, ON, Canada.<br />
#2266 LIPID HYDROPEROXIDE-DERIVED DNA<br />
ADDUCTS GENERATED THROUGH REDOX<br />
CYCLING OF BENZO(A)PYRENE QUINONE. J.<br />
Xu, S. Lee and I. A. Blair. Department <strong>of</strong> Pharmacology,<br />
University <strong>of</strong> Pennsylvania, Philadelphia, PA. Sponsor:<br />
S. Burchiel.<br />
#2267 METABOLISM OF 7H-DIBENZO[C,<br />
G]CARBAZOLE (DBC) OR BENZO[A]PYRENE<br />
(BAP) IN CYP1A2 OR AHR GENE KNOCKOUTS:<br />
IMPLICATIONS FOR CARCINOGENICITY. D.<br />
Ginsburg, G. Talaska, K. LaDow, B. Schumann, A. Puga<br />
and D. Warshawsky. Environmental Health, University<br />
<strong>of</strong> Cincinnati College <strong>of</strong> Medicine, Cincinnati, OH.<br />
#2268 CHARACTERIZATION OF STABLE<br />
BENZO[A]PYRENE-7, 8-QUINONE-DNA<br />
ADDUCTS IN CALF THYMUS DNA. J. A. Ross, G.<br />
Nelson, W. T. Padgett, N. Balu, G. R. Lambert and S.<br />
Nesnow. Environmental Carcinogenesis Division, U.S.<br />
EPA, Research Triangle Park, NC. Sponsor: D. Wolf.<br />
#2269 INDUCTION AND PERSISTENCE OF<br />
BENZO(A)PYRENE- AND DIBENZO[A,<br />
L]PYRENE-DNA ADDUCTS IN DNA REPAIR-<br />
PROFICIENT AND DEFICENT CELLS. W. A.<br />
Spencer and D. K. Orren. <strong>Toxicology</strong>, University <strong>of</strong><br />
Kentucky, Lexington, KY. Sponsor: M. Vore.<br />
#2270 COMPARISON OF DNA ADDUCT FORMATION<br />
BETWEEN TISSUES FROM MICE TREATED<br />
WITH COMPLEX PAH MIXTURES. T. D. Phillips,<br />
A. M. Gillespie, L. Cizmas, G. Zhou, T. J. McDonald, Y.<br />
Qian and K. C. Donnelly. Texas A&M University,<br />
College Station, TX.<br />
#2271 METABOLIC ACTIVATION AND PAH-DNA<br />
ADDUCT FORMATION FROM URBAN DUST<br />
PARTICULATE MATTER (SRM 1649A) IN<br />
HUMAN MAMMARY EPITHELIAL CELLS IN<br />
CULTURE. L. A. Courter and W. M. Baird.<br />
Environmental and Molecular <strong>Toxicology</strong>, Oregon State<br />
University, Corvallis, OR.<br />
#2272 DIESEL EXHAUST PARTICLES CAUSE<br />
INCREASED LEVELS OF DNA DELETIONS AND<br />
DNA ADDUCT FORMATION AFTER<br />
TRANSPLACENTAL EXPOSURE IN MICE. R.<br />
Reliene 1 , A. Hlavacova 1 , B. Mahadevan 2 , W. M. Baird 2<br />
and R. H. Schiestl 1 . 1 Pathology, Environmental Health<br />
and Radiation Oncology, UCLA, Los Angeles, CA and<br />
2 Environmental Molecular <strong>Toxicology</strong>, Oregon State<br />
University, Corvallis, OR.<br />
#2273 MLH1-DEFICIENT MICE ARE<br />
HYPERSENSITIVE TO PHIP-INDUCED<br />
MUTATION AND ABERRANT CRYPT FOCI:<br />
EVIDENCE FOR DIFFERENTIAL PROCESSING<br />
OF PHIP ADDUCT MISPAIRS BY THE<br />
MISMATCH REPAIR PATHWAY. S. Smith-Roe, S.<br />
S. Crain and A. B. Buermeyer. Environmental and<br />
Molecular <strong>Toxicology</strong>, Oregon State University,<br />
Corvallis, OR. Sponsor: L. Curtis.<br />
#2274 OXIDATIVE METABOLISM OF THE SERM,<br />
RALOXIFENE LEADS TO PROTEIN COVALENT<br />
MODIFICATION. J. Liu, Q. Li, C. Luckie, X. Yang,<br />
M. Chang, R. B. van Breemen, G. R. Thatcher and J. L.<br />
Bolton. Medicinal Chemistry and Pharmacognosy,<br />
College <strong>of</strong> Pharmacy, University <strong>of</strong> Illinois at Chicago,<br />
Chicago, IL.<br />
#2275 IDENTIFICATION OF ELECTROPHILE<br />
BINDING MOTIFS ON QUINONE-THIOETHER<br />
ADDUCTED RENAL PROTEINS. M. E. Bowen 1 , M.<br />
T. Labenski 1 , C. Kernag 1 , G. Tsaprailis 1 , M. A. Ali 2 , E.<br />
A. Mash 2 , T. J. Monks 1 and S. S. Lau 1 . 1 Pharmacology<br />
and <strong>Toxicology</strong>, University <strong>of</strong> Arizona, Tucson, AZ and<br />
2 Chemistry, University <strong>of</strong> Arizona, Tucson, AZ.<br />
Thursday Morning, March 10<br />
8:30 AM to 11:30 AM<br />
La Louisiane Ballroom B<br />
POSTER SESSION: APOPTOSIS<br />
Chairperson(s): Jessica Berthiaume, University <strong>of</strong> Minnesota, Duluth, MN.<br />
Displayed: 8:30 AM–11:30 AM<br />
Attended: 8:30 AM-10:00 AM<br />
#2276 MOLECULAR MECHANISMS OF<br />
HYDROQUINONE INDUCED APOPTOSIS. S. H.<br />
inayat-hussain 1,2 , V. Gogvadze 3 , S. Orrenius 3 and D.<br />
Ross 1 . 1 Pharmacology Sciences, University <strong>of</strong> Colorado,<br />
denver, CO, 2 Biomedical Sciences, Faculty <strong>of</strong> Allied<br />
Health Sciences, Universiti Kebangsaan Malaysia,<br />
Kuala Lumpur, wp, Malaysia and 3 <strong>Toxicology</strong> Division,<br />
Karolinska Institutet, Stockholm, Sweden.<br />
#2277 BIOCHEMICAL AND MICROARRAY ANALYSES<br />
OF BUPIVACAINE-INDUCED APOPTOSIS. A.<br />
Unami 1,3 , Y. Shinohara 2 , K. Omura 1 , M. Matsumoto 1 , Y.<br />
Oishi 1 and Y. Baba 3 . 1 <strong>Toxicology</strong> Research<br />
Laboratories, Fujisawa Pharmaceutical Co., Ltd.,,<br />
Osaka, Japan, 2 Institute for Genome Research, The<br />
University <strong>of</strong> Tokushima, Tokushima, Japan and<br />
3 Faculty <strong>of</strong> Pharmaceutical Sciences, The University <strong>of</strong><br />
Tokushima, Tokushima, Japan. Sponsor: M. Takahashi.<br />
#2278 1, 1-DICHLOROETHYLENE-INDUCED<br />
MITOCHONDRIAL DAMAGE PRECEDES<br />
APOPTOTIC CELL DEATH OF BRONCHIOLAR<br />
EPITHELIAL CELLS IN MURINE LUNG. E. J.<br />
Martin and P. Forkert. Department <strong>of</strong> Anatomy and Cell<br />
Biology, Queen’s University, Kingston, ON, Canada.<br />
222<br />
SOT’s 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
#2279 TMT TOXICITY IN HIPPOCAMPAL CELLS IS<br />
ASSOCIATED WITH INDUCTION OF BAX AND<br />
INOS EXPRESSION. L. zhang, L. li, K. Prabhakaran,<br />
J. L. Borowitz and G. E. Isom. Medicinal Chemistry and<br />
Molecular Pharmacology, Purdue University, West<br />
Lafayette, IN.<br />
#2280 GENDER -SPECIFIC DIFFERENCES IN<br />
APOPTOTIC INDICES IN RAT LIVER AFTER<br />
CHRONIC ETHANOL CONSUMPTION. T. V.<br />
Curry-McCoy 2 , R. L. White 1 , S. L. Todero 1 and T. M.<br />
Donohue 1 . 1 Research, VA Medical Center, Omaha, NE<br />
and 2 Pathology/Microbiology, University <strong>of</strong> Nebraska<br />
Medical Center, Omaha, NE. Sponsor: R. Pollenz.<br />
#2281 CALYCULIN A, A PP1/PP2A INHIBITOR, DELAYS<br />
APOPTOTIC SIGNALING IN TGHQ-TREATED<br />
HL-60 CELLS. M. Yang, S. S. Lau and T. J. Monks.<br />
Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong> Arizona,<br />
Tucson, AZ.<br />
#2282 SINGLE-WALLED CARBON NANOTUBES<br />
ACTIVATE RAW 264.7 MACROPHAGES: ROLE<br />
IN OXIDATIVE STRESS AND INFLAMMATORY<br />
RESPONSE. A. I. Potapovich 1 , A. N. Osipov 1 , E. R.<br />
Kisin 2 , D. Schwegler-Berry 2 , A. A. Shvedova 2 and V. E.<br />
Kagan 1 . 1 Department <strong>of</strong> EOH, Center for Free Radical<br />
& Antioxidant Health, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA and 2 Pathology & Physiology Research<br />
Branch, NIOSH, Morgantown, WV.<br />
#2283 PHYSICAL AND CHEMICAL INTERACTION<br />
BETWEEN CARDIOLIPIN AND CYTOCHROME<br />
C. N. A. Belikova 1,2 , A. N. Osipov 1,2 , A. A. Kapralov 1,2 ,<br />
M. V. Potapovich 1,2 and V. E. Kagan 1,2 . 1 Center for Free<br />
Radical and Antioxidant Health, University <strong>of</strong><br />
Pittsburgh, Pittsburgh, PA and 2 Department <strong>of</strong><br />
Environmental and Occupational Health, University <strong>of</strong><br />
Pittsburgh, Pittsburgh, PA.<br />
#2284 CARDIOLIPIN DESTABILIZES CYTOCHROME<br />
C IN MITOCHONDRIA AND MAKES ITS<br />
CATALYTIC SITE ACCESSIBLE TO SMALL<br />
LIGANDS: ROLE IN APOPTOSIS. A. N. Osipov 1,2 ,<br />
I. V. Kurnikov 2 , Y. A. Vladimirov 2 , N. A. Belikova 1,2 , D.<br />
A. Stoyanovsky 3 , M. V. Potapovich 1,2 , G. G.<br />
Borisenko 2 , A. A. Kapralov 1,2 , Y. Y. Tyurina 1,2 , V. A.<br />
Tyurin 1,2 , J. Jiang 1,2 , V. Kini 1,2 , A. Lysytsya 2 , V. B.<br />
Ritov 1 , A. M. Choi 3 , S. W. Ryter 3 and V. E. Kagan 1,2 .<br />
1 Center for Free Radical & Antioxidant Health,<br />
University <strong>of</strong> Pittsburgh, Pittsburgh, PA, 2 Department <strong>of</strong><br />
Environmental and Occupational Health, University <strong>of</strong><br />
Pittsburgh, Pittsburgh, PA and 3 Department <strong>of</strong><br />
Pulmonary Medicine and Surgery, University <strong>of</strong><br />
Pittsburgh, Pittsburgh, PA.<br />
#2285 BLOCKADE OF N-METHYL-D-ASPARTATE<br />
RECEPTORS BY KETAMINE PRODUCES LOSS<br />
OF MONKEY FRONTAL CORTICAL NEURONS<br />
IN CULTURE. C. Wang 1 , N. Sadovova 3 , X. Fu 2 , A.<br />
Scallet 1 , L. Schmued 1 , J. Hanig 4 and W. Slikker 1 .<br />
1 Division <strong>of</strong> Neurotoxicology, NCTR/FDA, Jefferson,<br />
AR, 2 Charles River Laboratories, Jefferson, AR,<br />
3 Division <strong>of</strong> Biochemical <strong>Toxicology</strong>, NCTR/FDA,<br />
Jefferson, AR and 4 CDER/FDA, Rockville, MD.<br />
#2286 ACTIVATION OF PEROXISOME<br />
PROLIFERATOR-ACTIVATED RECEPTOR<br />
ALPHA ENHANCES HEPATOCYTE APOPTOSIS.<br />
S. Xiao 1 , S. P. Anderson 2 , C. Swanson 1 , R. Bahnemann 3 ,<br />
K. A. Voss 4 , A. J. Stauber 1 and J. C. Corton 5,1 . 1 CIIT,<br />
Research Triangle Park, NC, 2 GSK, Research Triangle<br />
Park, NC, 3 BASF, Ludwigshafen, Germany, 4 USDA,<br />
Athens, GA and 5 ToxicoGenomics, Chapel Hill, NC.<br />
#2287 METABOLISM OF NITRO-PAHS ELICITS<br />
APOPTOTIC AND NECROTIC RESPONSES IN<br />
HEPA 1C1C7 CELLS. N. Asare 1 , K. Ask 2 , N.<br />
Landvik 1 and J. A. Holme 1 . 1 National Public Health<br />
Institute, Oslo, Norway and 2 Macmaster University,<br />
Hamilton, ON, Canada. Sponsor: E. Dybing.<br />
#2288 THE ROLES OF MITOCHONDRIA AND<br />
CASPASE-6 IN 7-12-DIMETHYL-<br />
BENZ[α]ANTHRACENCE-INDUCED BONE<br />
MARROW B CELL APOPTOSIS. J. K. Emberley 1 , J.<br />
J. Schlezinger 2 , H. Ryu 2 and D. H. Sherr 2 .<br />
1 Microbiology, Boston University School <strong>of</strong> Medicine,<br />
Boston, MA and 2 Environmental Health, Boston<br />
University School <strong>of</strong> Public Health, Boston, MA.<br />
#2289 AMELIORATION OF PARAQUAT AND<br />
CADMIUM CHLORIDE INDUCED APOPTOSIS<br />
BY κ-CARRAGEENAN IN RAT PLEURAL<br />
MESOTHELIAL CELL CULTURES. P. Kanade and<br />
J. M. Cerreta. Department <strong>of</strong> Pharmaceutical Sciences,<br />
Saint John’s University, Jamaica, NY. Sponsor: L.<br />
Trombetta.<br />
#2290 STUDY ON THE TOXICITY OF CADMIUM AND<br />
THE PROTECTIVE EFFECT OF FOOD<br />
COMPONENTS IN CELLS WITH HORMONE<br />
RECEPTORS. T. Kim, T. Kang, H. Moon, I. Kang, Y.<br />
Lee and S. Han. Endocrine <strong>Toxicology</strong> Division,<br />
National Institute <strong>of</strong> Toxicological Research, Seoul,<br />
South Korea.<br />
#2291 DIFFERENTIATION OF CISPLATIN-INDUCED<br />
DNA DAMAGE AND APOPTOSIS BY<br />
PHOSPHORYLATION OF HISTONE H2A.X. X.<br />
Feng 1 , A. Modi 2 , K. Stams 3 and P. Lord 1 . 1 Johnson &<br />
Johnson PRD, Raritan, NJ, 2 Columbia University, New<br />
York City, NY and 3 AstraZeneca Pharmaceuticals LP,<br />
Waltham, MA. Sponsor: C. Wang.<br />
#2292 CISPLATIN-INDUCED APOPTOSIS OF GC1<br />
TESTICULAR GERM CELLS MAY OCCUR BY<br />
AN AUTOCRINE MECHANISM INVOLVING<br />
FASL/FAS- OR TRAIL/DR5-MEIDATED<br />
SIGNALING. Y. Ye and J. H. Richburg. College <strong>of</strong><br />
Pharmacy, The University <strong>of</strong> Texas at Austin, Austin,<br />
TX.<br />
#2293 A DECREASE IN AKT LEVELS CORRELATES<br />
WITH SENSITIVITY TO ARSENIC-INDUCED<br />
GROWTH INHIBITION. M. Colombo, W. H. Miller<br />
and K. K. Mann. Lady Davis Institute for Medical<br />
Research, McGill University, Montreal, QC, Canada.<br />
THURSDAY<br />
up-to-date information at www.toxicology.org 223
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
THURSDAY<br />
#2294 CARDIOLIPIN IS A PREFERRED SUBSTRATE<br />
FOR CYTOCHROME C INDUCED OXIDATION<br />
DURING INTRINSIC APOTOSIS. V. A. Tyurin 1 , Y.<br />
Y. Tyurina 1 , A. Lysytsya 1 , A. A. Amoscato 2 , J. Jiang 1 ,<br />
Q. Zhao 1 , M. Zou 1 , V. B. Ritov 3 and V. E. Kagan 1 .<br />
1 Department <strong>of</strong> Environmental and Occupational<br />
Health, Center for Free Radical and Antioxidant Health<br />
University <strong>of</strong> Pittsburgh, Pittsburgh, PA, 2 Mass<br />
Spectrometry Facility, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA and 3 Department <strong>of</strong> Medicine, University<br />
<strong>of</strong> Pittsburgh, Pittsburgh, PA.<br />
#2295 CYTOCHROME C CATALYZED CARDIOLIPIN<br />
OXIDATION IS ESSENTIAL FOR THE RELEASE<br />
OF PROAPOPTOTIC FACTORS FROM<br />
MITOCHONDRIA. J. Jiang 1 , V. A. Tyurin 1 , Y. Y.<br />
Tyurina 1 , V. Kini 1 , P. Cai 1 , V. B. Ritov 2 and V. E.<br />
Kagan 1 . 1 Center for Free Radical and Antioxidant<br />
Health, Department <strong>of</strong> Environmental and Occupational<br />
Health, University <strong>of</strong> Pittsburgh, Pittsburgh, PA and<br />
2 Department <strong>of</strong> Medicine, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA.<br />
#2296 TWO FACETS OF ETOPOSIDE:PRO-<br />
APOPTOTIC AGENT AND ANTIOXIDANT. V. A.<br />
Kini 1 , Y. Y. Tyurina 1 , V. A. Tyurin 1 , A. Lysytsya 1 , J.<br />
Yalowich 2,1 and V. E. Kagan 1,2 . 1 Department <strong>of</strong> EOH,<br />
Center for Free Radical and Antioxidant Health,<br />
University <strong>of</strong> Pittsburgh, Pittsburgh, PA and<br />
2 Department <strong>of</strong> Pharmacology, University <strong>of</strong> Pittsburgh,<br />
Pittsburgh, PA.<br />
#2297 HL-60 CELLS WITH METABOLICALLY<br />
BIOENGINEERED POLYUNSATURATED<br />
CARDIOLIPIN MOLECULAR SPECIES EXERT<br />
INCREASED SENSITIVITY TO APOPTOSIS. Y. Y.<br />
Tyurina, V. A. Tyurin, Y. Fujii and V. E. Kagan.<br />
Department <strong>of</strong> Environmental and Occupational Health,<br />
Center for Free Radical and Antioxidant Health,<br />
University <strong>of</strong> Pittsburgh, Pittsburgh, PA.<br />
#2298 IDENTIFICATION OF NUR77 AGONISTS THAT<br />
INDUCE APOPTOSIS AND INHIBIT CANCER<br />
CELL SURVIVAL THROUGH NUCLEAR<br />
PATHWAYS. S. Chintharlapalli 1 , S. Papineni 1 , R.<br />
Burghardt 2 and S. Safe 1,3,4 . 1 Biochemistry &<br />
Biophysics, Texas A&M University, College Station,<br />
TX, 2 Veterinary Anatomy & Public Health, Texas A&M<br />
University, College Station, TX, 3 Veterinary Physiology<br />
& Pharmacology, Texas A&M University, College<br />
Station, TX and 4 Institute <strong>of</strong> Biosciences & Technology,<br />
Texas A&M University Health Science Center, Houston,<br />
TX.<br />
#2299 THE IBM OF SMAC IS DISPENSABLE FOR<br />
APOPTOTIC FUNCTION. S. P. Burke and J. B.<br />
Smith. Pharmacology and <strong>Toxicology</strong>, University <strong>of</strong><br />
Alabama Birmingham, Birmingham, AL. Sponsor: C.<br />
Lamartiniere.<br />
#2300 INVOLVEMENT OF THE AP-1 COMPLEX IN<br />
THE NEUROPROTECTIVE EFFECT OF PACAP<br />
AGAINST CERAMIDE-INDUCED TOXICITY. N.<br />
Aubert 1,2 , A. Falluel-Morel 2 , C. Fisch 1 , D. Vaudry 2 , S.<br />
de Jouffrey 1 , A. Fournier 3 , R. Forster 1 , H. Vaudry 2 and<br />
B. Gonzalez 2 . 1 CIT, Evreux, France, 2 INSERM-IFRMP<br />
23, Rouen, France and 3 INRS-Institut Armand Frappier,<br />
Quebec, Canada.<br />
#2301 ACTIVATION OF ENDONUCLEASE, OR<br />
CASPASE-ACTIVATED DNASE (CAD), AS A<br />
MARKER OF APOPTOSIS RATHER THAN<br />
NECROSIS IN DRUG- OR CHEMICAL-INDUCED<br />
ONCOSIS IN VIVO. S. D. Ray 1 , S. Stohs 2 and G. B.<br />
Corcoran 3 . 1 Mol. <strong>Toxicology</strong>. Prog./Pharmacology Scs.,<br />
AMS College <strong>of</strong> Pharmacology/LIU, Brooklyn, NY,<br />
2 AdvoCare International, Carrollton, TX and<br />
3 Pharmaceutical Sciences, Wayne State University,<br />
Detroit, MI.<br />
#2302 APOPTOSE TRIGGERED MICRONUCLEI: THE<br />
ROLE OF APOPTOSIS ON THE OUTCOME OF<br />
MICRONUCLEUS ASSAY. M. Kabiri. San<strong>of</strong>i-<br />
Aventis, Hattersheim, Germany. Sponsor: M. Bonnefoi.<br />
#2303 ISOLATION OF THE APOPTOSIS INDUCING<br />
CONSTITUENTS OF GUAIACUM SANCTUM L.<br />
AND GUAIACUM OFFICINALE L.<br />
(ZYGOPHYLLACCEAE) ON HUMAN BREAST<br />
CELLS IN VITRO. K. J. Chavez 1 , S. Schwaiger 2 , K.<br />
Renner 3 , J. A. Flanders 4 , H. Stuppner 2 and E.<br />
Rodriguez 5 . 1 Department <strong>of</strong> Comparative<br />
Environmental <strong>Toxicology</strong>, Cornell University, Ithaca,<br />
NY, 2 Institute fur Pharmazie, Abt Pharmakognosie,<br />
Universitae Innsbruck, Innsbruck, Austria, 3 Biozentrum,<br />
Division Molekulare Pathophysiologie, Medizinische<br />
Universitae Innsbruck, Innsbruck, Austria, 4 Department<br />
<strong>of</strong> Clinical Sciences and Molecular Medicine, Cornell<br />
University, Ithaca, NY and 5 Department <strong>of</strong> Plant<br />
Biology, Cornell University, Ithaca, NY.<br />
224<br />
SOT’s 44 th Annual Meeting
Author Index<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
The numerals following the author’s names refer to the abstract numbers. The asterisk after the abstract number<br />
indicates the author is the first presenter.<br />
A<br />
Aalbers, M ............................................... 903<br />
Aardema, M J ........................................ 2209<br />
Aase, A ..................................................... 450<br />
Abadin, H .............................................2086*<br />
Abbey, A ................................................. 1951<br />
Abbott, B ................................................ 1224<br />
Abbott, B D .............................................680*<br />
Abbott, L C ...................................... 618, 619<br />
Abdalla, E ...............................................1108<br />
Abdel-Rahman, A A ..............................962*<br />
Abdel-Rahman, M S ............................1923*<br />
Abdel-Rahman, S Z .................... 1274, 2236<br />
Abdelrahim, M ....................................1807*<br />
Abdullah, I ............................................ 1378<br />
Abdullah, S ............................................ 1780<br />
Abe, J ................................................ 831, 837<br />
Abe, K .................................................... 1424<br />
Abel, M D .............................................. 1255<br />
Abel, S J .................................................... 647<br />
Abel, S ..................................................... 113*<br />
Abou-Donia, M ..................................... 1952<br />
Abou-Donia, M B ................. 961, 962, 1620<br />
Abou-Hadeed, A H .................................. 79<br />
Abouzakhar, F S ....................................946*<br />
Abraham, V ..........................................1851*<br />
Abraham, W ............................................ 474<br />
Abromovitz, M W .................................. 372<br />
Acevedo, S ............................................... 414<br />
Acevedo, S P ......................................... 1279<br />
Achanzar, W .......................................... 1619<br />
Ackerman, J I .............................2205*, 2230<br />
Acosta-Saavedra, L C ..........627, 1146, 1875<br />
Adair, B .................................................. 1817<br />
Adair, B M ....................................692*, 1231<br />
Adami, H ................................................. 295<br />
Adamo, M ............................. 262, 558, 1462<br />
Adams, A ............................................... 1383<br />
Adams, D F ............................................536*<br />
Adams, J .................................................899*<br />
Adams, R J ............................................... 678<br />
Addai, A ................................................. 1498<br />
Adibzadeh, M ....................................... 1878<br />
Adkins, J N .............................................918*<br />
Adler, R .................................................. 1916<br />
Adlercreutz, H ...................................... 1490<br />
Adriaens, E ..................................... 481, 482,<br />
.............................................2006, 2009, 2015*<br />
Afan, R ..................................................... 473<br />
Affatato, A A ................................ 1274, 2236<br />
Afriyie-Gyawu, E ...................... 1283, 1309,<br />
.......................................................1400, 1402*<br />
Afshari, A ............................................... 1468<br />
Afshari, C .............................................. 1784<br />
Afshari, C A ............................................. 121<br />
Agca, Y ..................................................... 546<br />
Ahaghatu, E .......................................... 2190<br />
Ahlgren, S .............................................. 2260<br />
Ahmad, S .................................... 1138*, 1604<br />
Ahmed, A E ..................................214*, 1076<br />
Ahmed, R ................................................ 154<br />
Ahmed, S ................................................. 887<br />
Ahn, K .....................................................1148<br />
Ahn, M ..................................................... 552<br />
Ahr, H .....................................................2114<br />
Ahr, H J .................................................1735*<br />
Aiyar, R .................................................1383*<br />
Aizawa, Y ................................ 459, 607, 944<br />
Akahori, F ................................................ 954<br />
Aksinenko, A Y ................. 1936, 1937, 1938<br />
Akunyili, D N ....................................... 1439<br />
Al-Hamdani, S ...................................... 1589<br />
Al-Zoughool, M H ..............................1797*<br />
Alatorre Rico, J ........................................ 252<br />
Alavanja, M R ....................................... 1333<br />
Albano, E ................................................. 906<br />
Albershardt, D J .................................... 1499<br />
Alberston, T E ........................................... 46<br />
Albert, R ................................................. 1512<br />
Albertini, R J .........................................1030*<br />
Albores, A ................................................ 567<br />
Alcaraz-Contreras, Y ............................ 1412<br />
Alcocer, M .............................................. 1710<br />
Alden, C L ............................................. 2027<br />
Aldous, C N .......................................... 2152<br />
Aldous, K M .......................................... 1288<br />
Aldridge, J E ...........................................965*<br />
Aleksunes, L .........................................1921*<br />
Aleksunes, L M ................................. 67, 815<br />
Aleman, F ................................................ 684<br />
Alenius, H ............................................. 1885<br />
Aleo, M D ................................................ 520<br />
Alepee, N ................................................. 481<br />
Alex, L ...................................................... 466<br />
Alexander, B .......................................... 1798<br />
Alexander, M .......................................... 678<br />
Alexeeff, G ............................................. 2105<br />
Alexeeff, G V .............................. 1476*, 2111<br />
Alexiadis, V ............................................. 109<br />
Aley, P ...................................................... 608<br />
Algaier, J ................................................ 2069<br />
Ali, K .......................................................1139<br />
Ali, K A ................................................. 1140*<br />
Ali, M A .................................................. 2275<br />
Ali, M Y ...................................................516*<br />
Ali, S ....................................................... 1098<br />
Ali, S F ............................. 1099*, 1702, 1989*<br />
Alink, G ................................................1319*<br />
Allaben, W T ......................................... 1813<br />
Allan, L L ..................992, 1359, 1870, 1871*<br />
Allayee, H .............................................. 1373<br />
Allen, B ...................................................398*<br />
Allen, D ...................1997, 2005, 2007*, 2008<br />
Allen, D A ................................................ 663<br />
Allen, J ..............................2144, 2146*, 2147<br />
Allen, J W ............................................. 1103*<br />
Allen, R ...................................................1177<br />
Allen-H<strong>of</strong>fmann, B ....................... 105, 1364<br />
Allgood, J C ............................................. 735<br />
Allison, H M ............................................ 159<br />
Alnafisi, A ................................................ 503<br />
Alnouti, Y .............................................. 1244<br />
Alnouti, Y M .........................................2140*<br />
Alt, B ...................................................... 1790<br />
Alvarez, M M .......................................1609*<br />
Alvey, J D ................................................. 180<br />
Amacher, D ............................................. 490<br />
Amacher, D E ........................ 533, 716, 1915<br />
Amantana, A ........................................1246*<br />
Amaratunga, D ....................................... 755<br />
Amato, C A .............................................. 344<br />
Amato, C M ..........................................2179*<br />
Amberg, A ............................ 114, 510*, 1038<br />
Ambroso, J L ........................................... 905<br />
Ambrosone, C ........................................298*<br />
Amin, K ...................................... 1170, 1908*<br />
Ammenheuser, M ................................. 1042<br />
Amoruso, M A .....................................1514*<br />
Amoscato, A A ...................................... 2294<br />
An, J Y ...................................................... 720<br />
Anahara, R .............................................556*<br />
Anand, S .................................................. 956<br />
Anand, S S ......................................73, 2095*<br />
Anantharam, V ............................. 633, 1526<br />
And, N ..................................................... 578<br />
Anders, F ..............................................1073*<br />
Anders, N J .............................................. 985<br />
Andersen, M ........................................1982*<br />
Andersen, M E ........... 276, 848, 855*, 1676*<br />
Anderson, D ............................................ 437<br />
Anderson, G R .......................................713*<br />
Anderson, K E ......................................... 727<br />
Anderson, L M .....................................1013*<br />
Anderson, S A ......................................... 465<br />
Anderson, S P ....................57, 58*, 59, 2286<br />
Andreas, C ............................................1038*<br />
Andreasen, E A ..........................2241, 2242*<br />
Andrew, A S ............................................ 154<br />
Andrew, M M ........................................ 1005<br />
Andrews, D L ........................................ 1214<br />
Andrews, L .............................................. 805<br />
Andrus, A K ............................................ 269<br />
Anestis, D K .......................................... 2121<br />
Angerer, J ............................................... 1282<br />
Ankarberg, E ..........................................974*<br />
Ankley, G ............................................... 1583<br />
Ankley, G T ........................................... 1746<br />
Annaert, P ................................................ 268<br />
Annalora, A ............................................. 715<br />
Annalora, A J ..........................................724*<br />
Annis, M L ............................................. 1289<br />
Anraku, R .............................................. 1094<br />
Ansari, G ...........................................82, 912*<br />
Ansari, G A .................................. 1558, 1629<br />
Ansari, G S .............................................. 913<br />
up-to-date information at www.toxicology.org 225<br />
Ansari, R .................................................. 706<br />
Anthony, J ........................................ 776, 787<br />
Anthony, J S ............................................773*<br />
Antkiewicz, D S ...................................1825*<br />
Antonini, J M .....................939, 1449, 1468*<br />
Antony, V ............................................... 2108<br />
Antoun, M ............................................. 2219<br />
Antrobus, K ............................................. 124<br />
Ao, K ...................................................... 2043<br />
Aoki, T ................................................... 1931<br />
Aoki, Y ............................................. 393, 816<br />
Aouabdi, S ..............................................580*<br />
Api, A ........................1182, 1183, 1202, 1578<br />
Aposhian, H V .............................153, 1329*<br />
Aposhian, M M ..................................... 1329<br />
Apte, U ....................................................... 59<br />
Apte, U M ...................................1047, 1052*<br />
Aquino, E E ........................................... 1539<br />
Arakawa, S .............................................. 708<br />
Aravantinou, M .....................................609*<br />
Arcaro, K F ...........................................1281*<br />
Arcelin, G ...............................................1199<br />
Archer, D ............................................... 1710<br />
Arepalli, S ........................................ 701, 702<br />
Arfsten, D P ....................545*, 783, 792, 888<br />
Argonza, D .............................................. 473<br />
Ariazi, E ................................................. 1807<br />
Arimoto, R ............................................... 199<br />
Arjah, K .................................................. 1780<br />
Arjun, B .................................................. 2263<br />
Armagost, J ...........................................2231*<br />
Armour, C ................................................ 287<br />
Arnold, L L .................................. 1502, 1505<br />
Arocena, M ............................................ 2193<br />
Aronson, J .............................................. 1036<br />
Aronson, J F ..................................... 469, 498<br />
Arreola-Mendoza, L ............................ 1132*<br />
Arrieta, D E ..........................................1278*<br />
Arrington, D .........................................2128*<br />
Arthurton, J A ....................................... 1812<br />
Arts, J H ......................................1208*, 1518<br />
Arunajadai, S ........................................ 2056<br />
Arvidson, K ........................................... 2204<br />
Arzuaga, X ..............................................957*<br />
Asamoto, M ................................... 765, 1424<br />
Asare, N ................................................2287*<br />
Aschner, J ................................................. 620<br />
Aschner, M .....................486, 595, 599, 620*<br />
Asgharian, B ................................. 699, 2110*<br />
Ashby, J ................................ 124, 1736, 1739<br />
Ashikaga, T ................................ 1192*, 1193<br />
Ashley, J A ............................................. 1009<br />
Ask, K ..................................................... 2287<br />
Aspeslet, L J ........................................... 1255<br />
Aspinall, L J ........................................... 1293<br />
Asuzu, I U ............................................ 1411*<br />
Atchison, D K .........................................623*<br />
Atchison, W D ............... 623, 624, 625, 1059<br />
Atkins, J ................................................... 767<br />
Atkinson, A ..................................1139, 1140<br />
Atsumi, F ............................................... 1433<br />
Attenborough, S ................................... 1206<br />
Attia, M .................................................... 470<br />
Au, C .......................................................486*<br />
Aubert, N ..............................................2300*<br />
Aubrecht, J .............................333, 334*, 335,<br />
.............................................. 2205, 2230, 2233<br />
Auerbach, S ............................................. 290<br />
Augustine, M S ..................................... 1726<br />
Auletta, C .............................................1641*<br />
Auman, J T .............................................757*<br />
Ausman, K D ........................................ 1862<br />
Aust, A E .................................................638*<br />
Autenrieth, R ........................................ 1290<br />
Autenrieth, R L ..................................... 1593<br />
Authier, S ............................................... 1935<br />
Auttachoat, W ....................891, 1212*, 1716<br />
Avadhani, N G ........................................ 205<br />
Avakian, A P ...........................................1117<br />
Avila-Casado, M ....................................1153<br />
Avila-Costa, M ............................. 608*, 1153<br />
Avlasevich, S ......................................... 2212<br />
Avram, M D ................................... 153, 1329<br />
Awasthi, Y C ......................................... 1832<br />
Awooda, I .............................................. 1368<br />
Ayala-Fierro, F ..................................... 1190*<br />
Ayres, P H .................1185, 1187, 1515, 1516<br />
Azadi, S ...................................................1211<br />
Aziz, R M ..............................................1486*<br />
Azua, A .................................................. 1588<br />
B<br />
B’Hymer, C .....................................190*, 191<br />
Baba, Y ................................................... 2277<br />
Babb, A ..................................................1637*<br />
Babin, M C ................................... 2201, 2202<br />
Babu, R ................................................... 2004<br />
Babus, J .................................................... 422<br />
Babus, J B ............................................... 1260<br />
Babus, J K ............................1109, 1811, 1823<br />
Backes, W L ..................................... 725, 740<br />
Backlund, M .......................................... 1358<br />
Backstrom, M .......................................... 679<br />
Backus, G ..............................................1857*<br />
Bacon, C W .................................. 1395, 1396<br />
Badeaux, J V .............................................. 74<br />
Baden, D .................................................474*<br />
Baden, D G ...........................527, 1101, 2227<br />
Badger, T ................................................ 1036<br />
Badger, T M ........74, 274, 1737, 1918, 1919*<br />
Badham, H J .........................................1806*<br />
Bae, O ......................................................150*<br />
Bagchi, D ............................. 809, 1393, 1414<br />
Bagchi, M ............................809, 1393*, 1414<br />
Bagi, C ...................................................... 540<br />
Bagley, D M ........................................... 2001<br />
Bahnemann, R ................................. 58, 2286<br />
Bai, Y ........................................................ 817<br />
Bailey, A ................................................... 715<br />
Bailey, G P ................................................ 268<br />
Bailey, G S ................................................ 758<br />
Bailey, K ................................................1816*<br />
Bailey, M M ..........................................1067*<br />
Bailey, R E ...............................................1197<br />
Bailey, W J .................................................. 56<br />
Bain, L ...................................................... 576<br />
Baird, W M ................................. 1499, 1814,<br />
.............................................. 2019, 2271, 2272<br />
Bajt, M ...................................................1053*<br />
Baker, D .................................................... 530<br />
Baker, G .................................................... 210<br />
Baker, G L ...............................................917*<br />
Baker, S ............................................362, 625*<br />
Baker, V ............................................ 560, 577<br />
Bakheet, S A ..........................................1063*<br />
Balagopal, G .......................................... 1258<br />
Balagopal, g ..........................................1622*<br />
Balduchelly, Y ......................................... 219<br />
Bale, A S ..........................................49*, 1547<br />
Ball, G ........................................... 2098, 2103<br />
Ball, J G .................................................. 2122<br />
Ball, L M ........................................500, 1847*<br />
Balletta, L D ............................................... 60<br />
Ballinger, S W .......................................1010*<br />
Balu, N ................................................... 2268<br />
Bammler, T .............................................. 579<br />
Bammler, T K ........................................ 1495<br />
Bandiera, S M .............................1491*, 1562<br />
Bando, K ................................................ 1730<br />
Banerjee, A ............................................1047*<br />
Banker, G A ............................................ 1550<br />
Banks, C ............................1460*, 1462, 1464<br />
Bannon, D ...............................................1151<br />
Bannon, G .............................................. 1307<br />
Bansal, R .......................................986*, 1086<br />
Banyard, A ............................................. 1200<br />
Bao, A ......................................................... 47<br />
Bao, W ...............................1709*, 2148, 2150<br />
Barati, M ................................................ 1226<br />
Baravik, J G ........................................... 1299<br />
Barbee, G C ...........................................1593*<br />
Barbee, R ................................................ 1369<br />
Barbee, S J .............................................. 1482<br />
Barber, D .................................131, 161, 600*<br />
Barber, D S ............................................. 1546<br />
Barber, M ............................................... 1924<br />
Barber, R S ............................................. 1255<br />
Barchowsky, A .............................1133, 1162<br />
Barger, M ....................................... 360, 1443<br />
Barger, M W ............................................ 212<br />
Bargren, G L ................................ 1312, 1313<br />
Barhoumi, R .........................................1368*<br />
Barich, J .................................................. 1593<br />
Baril, M .................................................... 244
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Barile, F A .................................... 1621, 1627<br />
Barker, A M .............................................. 626<br />
Barker, D F ............................................. 1265<br />
Barker, S ................................................. 1441<br />
Barlow, B M ................................. 2175, 2194<br />
Barlow, N ................................................. 915<br />
Barnes, S ...............................................1915*<br />
Barnett, J B ................................... 1886, 1889<br />
Barnett, J F ............................................1075*<br />
Barnett, K .....................................1111, 1112*<br />
Baron, P .................................................... 701<br />
Barone, S .........................................378*, 512<br />
Barr, E ....................................................... 444<br />
Barr, E B ........................................... 162, 960<br />
Barraud, H ............................................. 2032<br />
Barrett, J C ............................................. 1044<br />
Barrett, S .................................................1511<br />
Barrick, D J ...........................................1840*<br />
Barrow, C ..............................................1683*<br />
Barrow, P C .............................................. 885<br />
Barry, R C ................................................. 918<br />
Bars, R .......................................... 1731, 1732<br />
Bartels, M ....................................1256, 1563*<br />
Bartels, M J .................................. 1041, 1242<br />
Bartlett, C ..............................................1791*<br />
Bartlett, M ...................................... 416, 1244<br />
Bartock, J .................................................. 508<br />
Barton, H ............................................... 2145<br />
Barton, H A ..................... 9, 854, 1232, 1296,<br />
...................................1568, 1684, 1685*, 1917<br />
Barton, S ................................................... 277<br />
Barve, S S ............................................... 1876<br />
Basford, T M .........................................2055*<br />
Basha, M .....................................1062*, 1532<br />
Basketter, D ............................................1196<br />
Basketter, D A .............................1201*, 1293<br />
Baskin, S I ........................................ 795, 796<br />
Bast, C ...................................................1482*<br />
Baston, D ................................................. 353<br />
Batki, C ..................................................... 133<br />
Batotsyrenov, B V ................................... 468<br />
Battelli, L .................................................. 360<br />
Batterman, S L ....................................... 1754<br />
Baudrimont, I .............................. 1435, 1440<br />
Bauer, A K .............................................. 1857<br />
Bauer, D ................................................1253*<br />
Bauer, L .................................................... 684<br />
Baughman, R H .................................... 1594<br />
Baumel, I .................................................. 768<br />
Baumel, I P .............................................. 328<br />
Baumgardner, J N ....................................74*<br />
Baumgartner, R ....................................... 240<br />
Baverel, G .............................................2135*<br />
Bavuso, N .............................................. 1779<br />
Baxter, C S ...............................................1165<br />
Baye, J ..................................................... 1897<br />
Bayless, K .............................................. 2126<br />
Baynes, R E .............2175, 2176, 2194*, 2196<br />
Bayse, G S .............................................1570*<br />
Bazot, D ..................................................1175<br />
Beall, H D ............................ 686, 1796, 1841<br />
Beamer, C A ............................................908*<br />
Beamonte, A ...........................................1175<br />
Beaubier, J .................................... 1803, 1804<br />
Beauchamp, T L ...................................1679*<br />
Becaria, A ............................................... 1448<br />
Beck, B .................................................... 2085<br />
Beck, B D .................... 384, 1071, 1472, 2083<br />
Beck, G R ................................................. 186<br />
Beck-Speier, I ........................................... 204<br />
Becker, E .................................................. 373<br />
Becker, H .................................................. 950<br />
Becker, P ................................................. 2092<br />
Becker, S ................................................... 457<br />
Beckwith, G ..........................................1999*<br />
Bedard, L L ............................................ 2265<br />
Bedford, M T ........................................1004*<br />
Beems, D ................................................ 1490<br />
Beger, R D ....................................... 509, 511*<br />
Begin, D ................................................... 244<br />
Behar, V ................................................. 1107*<br />
Behforouz, M ........................................ 1796<br />
Behrsing, H P ................... 1170, 1907*, 1908<br />
Beighley, C ............................................... 933<br />
Beischlag, T ..............................................90*<br />
Bejjani, B .................................................. 715<br />
Bekris, L M ...........................................1271*<br />
Belikova, N A .............................2283*, 2284<br />
Bell, D A ....................................................115<br />
Bell, D R ..................................................681*<br />
Bell, M ...................................................... 428<br />
Bell, R ..................................................... 1916<br />
Bellum, S .........................................618, 619*<br />
Belski, T ........................................... 776, 787<br />
Bemis, J C ................................84, 555, 2046*<br />
Ben, N .................................................... 1712<br />
Benbrahim-Tallaa, L ..............136, 138, 141*<br />
Bench, G ................................................... 162<br />
Bencherif, M ............................................ 471<br />
Bencic, D ................................................ 1583<br />
Bencic, D C ...........................................1582*<br />
Benhamed, M ........................................ 1731<br />
Benignus, V A ..................2088, 2091*, 2093<br />
Benkovic, S A ...........................................48*<br />
Bennett, M B .................................1186, 2229<br />
Benson, J .................................................. 527<br />
Benson, J M ............................................. 960<br />
Benson, R ............................................... 1474<br />
Bently, M .................................................. 686<br />
Benton, B .................................................. 793<br />
Benton, B J ............................................... 788<br />
Benz, R ................................................... 2204<br />
Beresford, L ........................................... 1200<br />
Berg van den, P T ................................... 953<br />
Berge, M A ............................................. 1238<br />
Berger, A .................................................. 537<br />
Bergman, A .................................. 1748, 2059<br />
Bergmann, M .......................................... 948<br />
Berman, F .............................................1023*<br />
Berman, K G .................................. 928, 1846<br />
Bermudez, E ...........................................517*<br />
Bermudez de Leon, M ........................... 567<br />
Berryman, L ........................................... 1935<br />
Berthiaume, J ......................................... 1849<br />
Berthiaume, J M ...........................206*, 1906<br />
Bertino, B ..................................... 2006, 2009<br />
Bessems, J .............................................2087*<br />
Bessems, J G ................................................ 9<br />
Best, D S .................. 1118*, 2143, 2148, 2151<br />
Besteman, E ............................................884*<br />
Betancourt, A M .....................................971*<br />
Betat, A ..................................................... 838<br />
Bettencourt, B .......................................... 462<br />
Betton, G .................................................. 824<br />
Betts, C J ....................................... 1207, 1999<br />
Betts, c ...................................................1200*<br />
Betz, L ......................................................539*<br />
Betz, L J .................................................... 518<br />
Beushausen, S ..........................................28*<br />
Beyer, J C .................................................. 804<br />
Beyer, L .................................................1472*<br />
Beyer, L A ................................................. 384<br />
Beyer, R .................................................. 1584<br />
Beyer, R P ................................................. 579<br />
Bezdecny, S ...........................................2052*<br />
Bhaskaran, V ............................... 1768, 1930<br />
Bhat, V .........................................2098*, 2103<br />
Bhat, V B ................................................ 1007<br />
Bhatnagar, A .......................................... 1844<br />
Bhatt, P ..................................................... 780<br />
Bhattacharyya, M H ................ 1031*, 1035*<br />
Bhave, V S .......................................... 77, 842<br />
Bhopale, K ..................................1558*, 1629<br />
Biagini, R E .............................................772*<br />
Biales, A D ............................................. 1582<br />
Bialkowska, A ....................................... 1013<br />
Bichet, N .......................................... 560, 577<br />
Bickham, J W ......................................... 1593<br />
Biddle, B M .................................. 2201, 2202<br />
Bieber, M .................................................. 801<br />
Biester, M .............................................. 2115*<br />
Bigsby, R M ............................................ 1749<br />
Bility, M T ...............................................588*<br />
Billam, M ..........................1308, 1309, 1595*<br />
Billiard, S ......................................687, 1581*<br />
Billin, A N ................ 55, 586, 587, 588, 1820<br />
Billings, K E ....................................146*, 147<br />
Billinton, N ............................................ 1037<br />
Billman, J ................................................1190<br />
Bills, P ....................................................... 413<br />
Billups, L .................................................2112<br />
Binder, E .................................................. 600<br />
Binetti, R R ............................................1631*<br />
Bion, A ...................................................... 446<br />
Birindelli, S ............................................ 1888<br />
Birkeland, A .......................................... 2120<br />
226<br />
Birnbaum, L ......................32, 309*, 310, 858<br />
Birnbaum, L S ..............311, 395, 1227, 1253<br />
Bisinger, Jr., E C .....................................1137<br />
Bisselink, B ............................................ 1056<br />
Bisson, J L ............................................... 611*<br />
Biswal, S ..................................................1811<br />
Bittner, A .......................................... 569, 755<br />
Bittner, A C ............................................ 1275<br />
Bjork, J .......................................... 1740, 2066<br />
Bjork, J A .............................827, 1849, 1906*<br />
Black, A T ......................................217, 2171*<br />
Black, S ................................................... 1252<br />
Blackshear, P ......................................... 1826<br />
Blackwell, D ............................................ 540<br />
Blair, I ....................................................1323*<br />
Blair, I A ..................1006*, 1043, 1815, 2266<br />
Blair, L ...................................................... 455<br />
Blake, J ................................................... 1252<br />
Blakemore, W ........................................ 1397<br />
Blancato, J ................................................ 858<br />
Blancato, J N .................................. 870, 1298<br />
Blann, E .................................................. 1912<br />
Blanton, C ................................................ 425<br />
Blanton, M ................................... 1369, 2248<br />
Blanton, M R ................................683, 2255*<br />
Blaugrund, E ..........................................1107<br />
Blazka, M E ................................1623, 2001*<br />
Bleumink, R ................................... 903, 1892<br />
Blodgett, D ............................................ 1943<br />
Bloemen, L J ............................................ 866<br />
Bloksma, N ............................................ 1208<br />
Blomme, E ......................................121, 557*<br />
Blomme, E A ............................................ 647<br />
Blonder, J M ............................................766*<br />
Blount, B C ............................................ 1288<br />
Blum, J .................................................... 1773<br />
Blystone, C ............................................ 2148<br />
Blystone, C R ............................... 2143, 2151<br />
Boadas-Vaello, P ................................... 1092<br />
Bobb, A J .......................................... 783, 792<br />
Bobseine, K ............................................ 1743<br />
Bobst, S M ...............................................376*<br />
Bode, C ........................................... 485, 2215<br />
Bodian, D ................................................... 61<br />
Boegehold, M A .................................... 1443<br />
Boekelheide, K ............................................ 8<br />
Boere, A F ............................................... 1446<br />
Boere, J F .................................................. 929<br />
Boermans, H ........................................... 883<br />
Bogdan, G M ......................................... 1048<br />
Bogue, M A ................................................ 60<br />
Bohlen, H ............................................... 1996<br />
Bohn, A A ................................................. 875<br />
Bohonowych, J ........................................ 353<br />
Bohonowych, J E .............................95*, 106<br />
Boitier, E ..........................................118, 2131<br />
Boivin, G P ............................................. 1512<br />
Bolanos, B ................................................ 445<br />
Boldt, S E ....................................... 716, 1915<br />
Bolger, P M .............................................292*<br />
Bollen, L S .............................................. 1390<br />
Bolte, H F ............................................... 1641<br />
Bolton, J L .......................... 1573, 1809, 2274<br />
Bombail, V ............................................. 1375<br />
Bombick, B R ................................1185, 1187<br />
Bondy, G .................................................. 128<br />
Bondy, S C ............................................. 1448<br />
Bonventre, J V ......................................... 197<br />
Boobis, A R .............................................669*<br />
Boohaker, J G ......................................... 1067<br />
Boon, L ..................................................... 903<br />
Boon, N A ................................................ 437<br />
Boone, S ................................................. 2159<br />
Boor, P .................................................... 1558<br />
Boor, P J .................................................. 1832<br />
Boor, p ...................................................... 825<br />
Boorman, G ................................. 1376, 1855<br />
Boorman, G A ......................................... 127<br />
Borazjani, A ........................................... 1569<br />
Bordelon, N R ........................................584*<br />
Boren, M .................................................. 540<br />
Borgeest, C ........................................... 1811*<br />
Borgerding, M F ...........................1185, 1187<br />
Borgert, C ................................................370*<br />
Borgert, C J ...............................................31*<br />
Borges, H T ............................................ 1485<br />
Borghi, L .................................................. 242<br />
Borgh<strong>of</strong>f, S J ................................... 862, 1228<br />
Borisenko, G G ...................................... 2284<br />
Born, J ......................................................... 89<br />
Borne, N ................................................... 484<br />
Borowitz, J L ................................ 1543, 2279<br />
Borracci, P .............................................. 1435<br />
Borsay Horowitz, D ............................. 1745<br />
Borst, P ................................................... 1051<br />
Bortner, C ................................................1114<br />
Botta, D .................................................... 579<br />
Bottenberg, P ..........................................1188<br />
Bouchard, M .................................432, 2156*<br />
Bouchard, P ......................... 464, 1632, 2027<br />
Bouldin, A ................................................ 326<br />
Bounous, D I ..............................................11<br />
Bourdelais, A J .....................474, 1101, 2227<br />
Bourdelais, A J .......................................527*<br />
Bourdi, M ................................................. 905<br />
Bourne, N .............................................. 1628<br />
Boutherin-Falson, O ............................1240*<br />
Boutros, P C ........................................... 1383<br />
Boverh<strong>of</strong>, D R ...........101, 1363*, 1382, 1759<br />
Bowen, L D ............................................ 1009<br />
Bowen, M E ..........................................2275*<br />
Bowen, N ......................................... 560, 577<br />
Bowlus, C L ............................................637*<br />
Bowman, B .............................................. 356<br />
Bowman, Z .............................................207*<br />
Boyce, R W ............................................ 1828<br />
Boyd, H .................................................... 680<br />
Boyer, J L ........................................ 465, 1706<br />
Boyes, W K ....................................49, 1332*,<br />
................................. 1335, 1337*, 2088*, 2093<br />
Boykin, B ............................................... 1623<br />
Boykin, E ............................................... 1896<br />
Boykin, E H ................................1214, 1715*<br />
Boysen, G ................................. 193, 523, 525<br />
Brackman, K .......................................... 2069<br />
Bradford, B ............................................ 1046<br />
Bradford, B U .................................... 60, 759<br />
Bradlee, C A ............................................ 284<br />
Brady-Roberts, E .................................... 768<br />
Braen, A ..................................................1181<br />
Brambila, E ...........................................1619*<br />
Bramble, L A ............................................ 449<br />
Brand, R .................................... 2172*, 2172*<br />
Brasel, J ...................................................958*<br />
Braselton, E W ........................................ 534<br />
Brasic, J R ................................................. 678<br />
Brattin, B ................................................ 1309<br />
Braun, K ................................................. 1038<br />
Bray, B J .................................................. 1489<br />
Bray, C .......................................................83*<br />
Bray, K C ................................................ 1796<br />
Braydich-Stolle, L ................................1625*<br />
Bredfeldt, T G ....................... 146, 147*, 1161<br />
Bredow, S .................................... 1141, 1142*<br />
Breen, M ................................................. 1467<br />
Brees, D .................................................... 490<br />
Brellenthin, R P ....................................2076*<br />
Brennan, R ..............................126, 338*, 522<br />
Brennan, R J ........................................... 1830<br />
Brent, R L ............................................... 2096<br />
Bressler, J P ............................................ 1263<br />
Breysse, P ................................................. 428<br />
Bricarello, A ............................................. 804<br />
Bridge, K A .............................................. 930<br />
Brien, J F ................................................... 935<br />
Brignoli, S R ............................................ 806<br />
Brigo, E .................................................1967*<br />
Brimfield, A A ........................................781*<br />
Brix, A E ................................................. 1506<br />
Broadwin, R .......................................... 1476<br />
Brock, B .................................................1532*<br />
Broderick, D .......................................... 1608<br />
Brodsky, B ........................................ 779, 784<br />
Brody, A R ................................................ 635<br />
Bromberg, P A ....................................... 1450<br />
Bronaugh, R L ....................................... 2177<br />
Bronley-DeLancey, A ..........................1559*<br />
Bronstein, R ............................................. 412<br />
Brooks, A .................................................645*<br />
Brooks, D ................................................. 686<br />
Brooks, E ................................................ 1814<br />
Brooks, J ................................................1810*<br />
Brooks, J D ......................... 2175, 2194, 2197<br />
Brorby, G .................................................. 409<br />
Brott, D .............................. 824*, 1626, 1843*<br />
Broud, D .................................................. 902<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Broughton, D S ......................................272*<br />
Brouillette, W ........................................ 1785<br />
Brown, A P ..............................................529*<br />
Brown, C .......................................... 210, 425<br />
Brown, C D .............................................. 917<br />
Brown, J P .....................................1521, 2111<br />
Brown, K G .............................................388*<br />
Brown, L ...............................................1089*<br />
Brown, M J ............................................1353*<br />
Brown, P J ...............................................737*<br />
Brown, P W ............................................. 532<br />
Brown, R .......................................... 378, 584<br />
Brown, R D .............................................. 878<br />
Brown, R P ............................................. 2136<br />
Brown, S C ............................................2108*<br />
Brown-Borg, H ........................................ 582<br />
Brownawell, A ........................................ 374<br />
Brubaker, G ............................................. 696<br />
Bruce, G M ............................................2102*<br />
Bruce, R .................................................. 1520<br />
Bruce, R M ..............................................383*<br />
Bruckner, J ..................................... 956, 2039<br />
Bruckner, J V ................................ 402, 1243,<br />
.............................................. 1245, 1247, 2095<br />
Bruckner*, J V ......................................... 729<br />
Bruening, T ............................................ 1282<br />
Brundage, K M ................1886, 1887*, 1889<br />
Brundage, R A ...................................... 1211*<br />
Brune, B ..................................................2116<br />
Bruner, L ................................................ 1630<br />
Brunet, R C ............................................ 2156<br />
Bruno, M E ...........................64*, 1005, 1900<br />
Bruschi, S ................................................. 813<br />
Bryant, S ........................................... 569, 755<br />
Brynczka, C ..........................................1538*<br />
Bucher, J ................................................... 793<br />
Bucher, J R ............................. 33, 1800, 2185<br />
Buchmann, E ......................................... 1856<br />
Buchweitz, J P ........................................876*<br />
Buck, R C ................................................. 952<br />
Buckalew, A ........................................... 1733<br />
Buckelew, A R ........................................1119<br />
Buckley, B .............................................. 1958<br />
Buckley, D B ...............................1762*, 1763<br />
Buckley, L .............................................. 1385<br />
Buckpitt, A ............................................... 210<br />
Buckpitt, A R ........................................... 916<br />
Budnik, J ...............................................2030*<br />
Budroe, J D ...........................................2109*<br />
Buelke-Sam, J .......................................... 978<br />
Buermeyer, A B ..................................... 2273<br />
Buettner, A ............................................. 1518<br />
Buffington, C ........................................... 355<br />
Buffmum, D .......................................... 1898<br />
Bugrim, A .................................... 1377, 1378<br />
Buhler, D R .......................... 738, 2019, 2020<br />
Bui, Q Q ................................................1390*<br />
Builee, T L ................................................ 979<br />
Bullard, B ................................................. 537<br />
Bulliet, R ...........................................201, 711<br />
Bunaciu, R P .......................................... 1488<br />
Bunderson, M ....................................... 1841<br />
Bunn, W B ................................................ 400<br />
Burback, B ................................... 1233, 1234<br />
Burback, B L ...........................................194*<br />
Burch, L H ............................................. 1846<br />
Burchiel, S W ..................................302*, 892<br />
Burdick, A D .................................302, 1820*<br />
Burgess, J ................................................. 732<br />
Burgess, M F .............................................17*<br />
Burgess, S C ................................... 971, 1299<br />
Burghardt, R ................................ 2126, 2298<br />
Burghardt, R C ...................................... 1368<br />
Burgin, D E .............................................395*<br />
Burgoon, L D .....................101, 1363, 1382*,<br />
.......................... 1383, 1759, 1760, 1771, 1772<br />
Burin, G .................................................... 949<br />
Burka, L .................................................... 732<br />
Burka, L T .......................................116, 1230<br />
Burke, K ................................................1058*<br />
Burke, S P .............................................2299*<br />
Burleson, F ............................................... 872<br />
Burleson, G .............................................. 872<br />
Burnett, D ................................................ 793<br />
Burnett, D C ............................ 775, 788, 794<br />
Burnett, J .................................................246*<br />
Burnett, V L ............................................108*<br />
Burns, A M ............................................... 759<br />
Burns, C ................................................. 1824<br />
Burns, F J ............................................... 1045<br />
Burns, K A ................................................53*<br />
Burns, L M ............................................... 268<br />
Burns, T D ............................................. 1396<br />
Burns-Naas, L ......................................... 314<br />
Burris, J .................................................. 1236<br />
Burt, J W .....................................1382, 1772*<br />
Bus, J S .........................................1242, 1666*<br />
Buse, E ................................. 168, 1105*, 1636<br />
Bush, A I ................................................1661*<br />
Bushel, P R ................................................119<br />
Bushman, W .............................................110<br />
Bushman, W A ........................................ 550<br />
Bushnell, P J ............... 49, 1335, 1547, 2088,<br />
...................................2089*, 2090, 2092, 2093<br />
Bussiere, J L ............................................. 499<br />
Butala, J H ................................................ 264<br />
Butenh<strong>of</strong>f, J .............1236, 1740*, 1798, 2066<br />
Butenh<strong>of</strong>f, J L ........................................ 1906<br />
Butler, R ................................................2022*<br />
Butterworth, B C ................................... 1746<br />
Butterworth, L ......................................... 882<br />
Byers, J ................................................... 2033<br />
Byrd, D M ...............................................374*<br />
C<br />
Cabonce, M ............................................. 532<br />
Caddick, H T ......................................... 1207<br />
Cadena, L ................................................. 597<br />
Cadet, J L ............................................... 1544<br />
Caguyong, M J ........................................ 589<br />
Cahill, P ................................................. 1037<br />
Cai, B ...................................................... 1821<br />
Cai, L .................................1226, 1836, 1839*<br />
Cai, P .....................................912, 913*, 2295<br />
Cai, Q ..........................................1308*, 1595<br />
Cai, W ..................................................... 1796<br />
Cai, Z ........................................................ 537<br />
Cain, S P ................................................. 1556<br />
Cairns, S ................................................. 2212<br />
Calderon, R L .......................................... 692<br />
Calderon-Aranda, E ............................... 253<br />
Calderon-Aranda, E S ....... 627*, 1146, 1875<br />
Calderwood, D J ..................................... 462<br />
Caldwell, J C ........................................... 401<br />
Caldwell, R .............................................169*<br />
Cali, J ............................................. 201*, 711*<br />
Calimlin, M ............................................. 473<br />
Calis, K ............................... 1776, 1777, 1778<br />
Calkins, M ............................................1523*<br />
Calkins, M J ............................................. 814<br />
Callaghan, T L ....................................... 1229<br />
Camacho, I .............................................. 365<br />
Camacho, S .............................................. 254<br />
Camp, S .................................................... 997<br />
Campain, J A ......................................... 1306<br />
Campanha, H M ..................................1948*<br />
Campbell, A ..........................................1448*<br />
Campbell, C T ....................................... 1419<br />
Campbell, J .................................... 416, 2039<br />
Campbell, J L ..................................861*, 869<br />
Campbell, M ..........................................1140<br />
Campbell, M R .........................................115<br />
Campen, M D .......................................... 960<br />
Campen, M J ..........................................455*<br />
Camus, L .................................................. 838<br />
Candelas, R ............................................. 253<br />
Candrl, J S .............................................. 1289<br />
Canerdy, T ............................................... 809<br />
Canham, B ................................... 1465, 1466<br />
Cannady, R D .......................................... 976<br />
Cannon, J R ..........................................1528*<br />
Cano, M ................................................. 1502<br />
Canpolat, E .............................................. 894<br />
Cantor, G H ........................................... 1930<br />
Cantor, J ................................................... 938<br />
Cantor, J O ............................................... 925<br />
Cantor, R M ........................................... 1373<br />
Cao, C ............................................. 484, 1628<br />
Cao, J .....................................................2036*<br />
Cao, Y ......................................................... 89<br />
Cao, Z ................................1827*, 1833, 1834<br />
Capen, C .................................................. 671<br />
Cappadoro, M ....................1188, 2006, 2009<br />
Cappon, G D ................................. 273, 1802<br />
up-to-date information at www.toxicology.org 227<br />
Car, B D ........................................ 1768, 1930<br />
Carbone, D L ................................209, 1718*<br />
Carchman, R ............................................ 408<br />
Carchman, R A ............................ 1292, 2161<br />
Carlisle, J C .............................................. 254<br />
Carlock, L L ............................................. 499<br />
Carls, N .................................................. 2232<br />
Carlson, T ................................................ 529<br />
Carmichael, P L ..................................... 2264<br />
Carnell-Bachman, A N ..............1786*, 1787<br />
Carnes, K ............................................... 1373<br />
Carney, E ...............................................1684*<br />
Carney, E W ..................................282, 2249*<br />
Carney, S A ...........................................1824*<br />
Caro, A A ..............................................1722*<br />
Carpenter, S .................................. 802*, 803*<br />
Carr, D F ................................................ 1276<br />
Carr, G J ................................................. 1371<br />
Carr, R L ..................................969, 970*, 971<br />
Carr, W C ............................................... 2152<br />
Carratu, M ............................................. 1435<br />
Carrier, G ....................................... 432, 2156<br />
Carruthers, C M .....................................551*<br />
Carstens, J .............................................. 1241<br />
Carte, B K ................................................... 94<br />
Carter, H ................................................ 1292<br />
Carter, J .......................................... 204, 1445<br />
Carter, J M ............................................1698*<br />
Carter, W ................................................ 2161<br />
Carter, Jr., W ............................................ 408<br />
Carvalho, R A .......................................1835*<br />
Carvan, M J ........................................... 2238<br />
Casati, S ......................................... 484, 1628<br />
Casavant, R H ......................................... 783<br />
Casbohm, S L .......................................... 780<br />
Casciano, D A ........................................ 1381<br />
Casella, G ................................................. 370<br />
Cashman, J .............................................. 109<br />
Cashman, J R ........................................1554*<br />
Casillas, R P ................................... 780, 2202<br />
Casper, E ................................................ 1048<br />
Cassee, F .........................................307*, 437<br />
Cassee, F R ..................................... 929, 1446<br />
Castaigne, J .............................. 170, 544, 807<br />
Casteel, S W ............................................1151<br />
Castellino, S ............................................. 491<br />
Castle, J .................................................... 287<br />
Castoldi, A F ................................ 1055, 2051<br />
Castorena-Torres, F ...............................567*<br />
Castranova, V ...................... 701, 702, 1443,<br />
.............................................. 1449, 1468, 2188<br />
Castro, L ................................................ 1114*<br />
Cate, M ................................................... 1246<br />
Catlin, M .................................................. 431<br />
Catranova, V ........................................... 212<br />
Cattley, R C .............................................. 581<br />
Caudle, M ...........................973, 1529, 1545*<br />
Cawley, T J ............................................... 282<br />
Cawthon, D R ..................1098, 1099, 1702*<br />
Cayatte, C .............................................1732*<br />
Cebrian, M ............................................... 427<br />
Cebrian, M E ..............252, 1146, 1455, 1875<br />
Cederbaum, A I ..................................... 1722<br />
Cerbon, M ................................................ 139<br />
Cerreta, J M ......................... 925, 1833, 2289<br />
Cerreta, J M ............................................. 934<br />
Cerven, D R ........................2011, 2012, 2207<br />
Chacko, M S .......................................... 1801<br />
Chahbane, N ......................................... 2050<br />
Chakrabarti, S K ....................................1131<br />
Chakraborty, C ...................................... 1609<br />
Chamberlain, M .................................... 1293<br />
Chambers, H ......................................... 1946<br />
Chambers, H W .................................... 1947<br />
Chambers, J ........................................... 2159<br />
Chambers, J E ......................... 969, 970, 972,<br />
.............................................1299*, 1946, 1947<br />
Chan, D W ............................................... 254<br />
Chan, H .................................................. 1622<br />
Chan, J Y .......................................... 815, 821<br />
Chan, K .................................................1926*<br />
Chan, P ................................................... 1425<br />
Chan, V ...........................................571*, 963<br />
Chan, W K ................................................. 98<br />
Chandar, N ............................................ 1602<br />
Chandler, C M ......................................... 719<br />
Chandraratna, R ....................................... 57<br />
Chandraratna, R A ................................... 59<br />
Chaney, D ...............................................1140<br />
Chaney, J G .............................................1197<br />
Chang, C ........................................ 710, 1501<br />
Chang, F T ............................................ 1184*<br />
Chang, L W ........................................... 1724<br />
Chang, M ....................................1809*, 2274<br />
Chang, S ..................................................186*<br />
Chang, T K ............................................ 1491<br />
Chang, W .................................... 454*, 1876*<br />
Chang, X ................................. 92*, 104, 1165<br />
Chang, Y .................................................. 780<br />
Chao, S L .................................................. 976<br />
Chao, Y ................................................... 1279<br />
Chapin, R E ........................................8, 1121<br />
Chappell, L L ..........................................155*<br />
Charbonneau, M ................764, 1651*, 1790<br />
Charles, G D ...........................................585*<br />
Charney, D ......................... 1776, 1777, 1778<br />
Charnley, G ...........................................1343*<br />
Charron, A ............................................. 2172<br />
Chatterjee, A ...............................1414, 2004*<br />
Chaudhary, A M ..................................1588*<br />
Chavez, B ........................................608, 1153<br />
Chavez, K J ...........................................2303*<br />
Cheeseman, M ...........................1317*, 2204<br />
Cheever, K L ...................................190, 191*<br />
Chegini, N ..............................................1113<br />
Chelonis, J J ............................................. 987<br />
Chen, A .................................................... 978<br />
Chen, C .................................................1220*<br />
Chen, D .................................................. 1939<br />
Chen, G .........................................187*, 1361<br />
Chen, H ....................................... 1143*, 1144<br />
Chen, J ............................................ 241, 1264<br />
Chen, J J ................................................. 2181<br />
Chen, L ...........................305*, 440, 574, 697,<br />
..................................... 941, 1445, 1603, 2216,<br />
.............................................. 2217, 2218, 2220<br />
Chen, L C ..............................................1933*<br />
Chen, M ..................................................631*<br />
Chen, M K ............................................... 678<br />
Chen, P ................................................... 1582<br />
Chen, Q .................................................. 1061<br />
Chen, Q M ............................112, 1725, 1848<br />
Chen, S ..................................................1360*<br />
Chen, T ...............................747*, 1565, 1757,<br />
.......................... 2216, 2217, 2218, 2220, 2222<br />
Chen, T B ............................................... 1468<br />
Chen, T S ................................................ 1876<br />
Chen, X ....................................... 1156, 1189*<br />
Chen, Y .................................227*, 466, 1599,<br />
................................. 1782*, 1828, 1922, 2026*<br />
Chen, Z .................................................. 1467<br />
Chen, J ................................................... 1131*<br />
Cheng, C N ...........................................1621*<br />
Cheng, D .................................................725*<br />
Cheng, E ................................................ 1408<br />
Cheng, H ...................................................42*<br />
Cheng, J ...................................................... 42<br />
Cheng, T .......................434, 435, 454, 1452*<br />
Cheng, X .................................................564*<br />
Cheng, X G ............................................ 1220<br />
Cheng, Y ...................................... 1058, 1452<br />
Cheng, Y J .............................................1724*<br />
Chengelis, C P ......................................1394*<br />
Cherian, G ................................................. 78<br />
Cherian, G M ......................................... 1613<br />
Chern<strong>of</strong>f, N ........................................... 1438<br />
Cherr, G N ............................................. 1087<br />
Cherrington, N J ........................... 815, 1761<br />
Chetty, C S ..............................................613*<br />
Cheung, J K ........................................... 2230<br />
Cheung, P ................................................ 348<br />
Chhabra, R ..........................1181, 2035, 2070<br />
Chi, R P .................................................. 1716<br />
Chiarappa, P ......................................... 1435<br />
Chiaro, C .................................................. 715<br />
Chiaro, C R ...............................................89*<br />
Chibout, S .................................................. 61<br />
Chico-Galdez, V ................................... 1039<br />
Chigurupati, M ..............................590*, 591<br />
Chilakapati, J ................................731*, 2137<br />
Chintharlapalli, S ................................2298*<br />
Chipman, K ................................. 1375, 2234<br />
Chittim, B .............................................. 1363<br />
Chiu, H .................................................. 1054<br />
Chiu, N .................................................1804*<br />
Chiu, N H .............................................1803*
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Cho, D ............................................ 186, 1635<br />
Cho, H .................................................... 1857<br />
Cho, I ...................................................... 1215<br />
Cho, J .........................................................111<br />
Cho, M ............................................... 41, 186<br />
Cho, T M .................................................358*<br />
Cho, Y ................................... 907, 1409, 1503<br />
Chohan, S .............................................. 1551<br />
Choi, A M .............................................. 2284<br />
Choi, B ...................................590, 591*, 2263<br />
Choi, C ..............................1409, 1427, 1531*<br />
Choi, C J ..................................................633*<br />
Choi, J ................................. 1524, 1531, 2168<br />
Choi, M .......................................... 156, 1007<br />
Choi, Y W ...............................770, 771*, 774<br />
Choich, J ................................................... 768<br />
Choksi, N ................1997*, 2005, 2007, 2008<br />
Choksi, N Y ....................................662, 663*<br />
Chou, C .................................................2181*<br />
Chou, D .................................................. 1603<br />
Chou, D K .......................................574, 941*<br />
Chou, I ................................... 574, 941, 1603<br />
Chou, J W .................................................119<br />
Chou, N ....................................... 1050, 1766<br />
Chou, S J ...............................................1483*<br />
Chou, Y .................................................... 414<br />
Choudhury, E .......................................... 483<br />
Choudhury, H ................................285*, 383<br />
Chouinard, L ........................................... 173<br />
Chow, J C ................................................. 304<br />
Chowdhury, M J ..................................1756*<br />
Chowdhury, U K .........................153*, 1329<br />
Choy, D .................................................. 2120<br />
Chris, B .................................................. 1927<br />
Christian, B J ........................................... 804<br />
Christian, M .......................................... 1738<br />
Christiani, D C ........................................ 441<br />
Christopher, J P ....................................2079*<br />
Chu, A C ...................................... 1752, 2049<br />
Chu, M D ..................................... 1752, 2049<br />
Chung, C .................................................. 905<br />
Chung, H ............................................... 1635<br />
Chung, J ......................................... 150, 1564<br />
Chung, K ....................................... 717, 1454<br />
Chung, W ...........................738, 2019*, 2020<br />
Chung, Y ............... 1213, 1409, 1427*, 1714*<br />
Chung, Y H .............................................. 202<br />
Churchwell, M I ............ 293, 361, 502, 1565<br />
Ciaccio, P ........................................173, 508*<br />
Ciak, J M ...............................................1831*<br />
Ciencewicki, J M ....................................447*<br />
Cifone, M A ........................................... 2214<br />
Cimafranca, M .....................................2047*<br />
Cisneros, B ............................................... 567<br />
Ciurlionis, R ............................ 121, 557, 647<br />
Cizmas, L ..................................... 1290, 2270<br />
Cizza, G ............................. 1776, 1777, 1778<br />
Clapp, C ................................................. 1201<br />
Clapp, C J ............................................... 1293<br />
Clark, A .................................................. 2069<br />
Clark, A J .................................................. 269<br />
Clark, C ............................................ 776, 787<br />
Clark, D .................................................. 1844<br />
Clark, G C ...................................1752, 2049*<br />
Clark, K .................................................... 410<br />
Clark, M ................................................... 921<br />
Clark, O E ...............................................782*<br />
Clark, S ................................................... 1828<br />
Clarke, J ................................................1994*<br />
Claude, J .................................................. 470<br />
Claude, N ...............................................1175<br />
Claus, R .................................................... 486<br />
Claus Henn, B ......................................1277*<br />
Clegg, E .................................................. 1998<br />
Clemens, D L ......................................... 1657<br />
Clewell, H .....................................261, 1689*<br />
Clewell, H J ............................. 350, 847, 854<br />
Clewell, R .............................................. 1689<br />
Clewell, R A ....................................276*, 862<br />
Cline, P ..................................................2023*<br />
Clipson Miller, T ........................2101, 2104*<br />
Cloak, C ..................................................677*<br />
Clode, S .................................................... 681<br />
Clodfelter, S ........................................... 1009<br />
Clothier, B .............................................. 1903<br />
Clothier, R ...................................... 484, 1628<br />
Coates, N H ................................. 1714, 1715<br />
Coatney, R ..............................................341*<br />
Coban, A .....................................1955, 1956*<br />
Coccini, T ....................................1055*, 2051<br />
CodiKing, S ........................................... 1280<br />
Coeshott, C .............................................. 766<br />
C<strong>of</strong>fey, E M .............................................. 121<br />
C<strong>of</strong>fey, T ..................................................389*<br />
C<strong>of</strong>fin, D D ............................................ 1841<br />
C<strong>of</strong>fin, J ...................................................686*<br />
Cohen, B .................................................. 171<br />
Cohen, J ...................................................431*<br />
Cohen, M ......................................636*, 1453<br />
Cohen, S ......................................... 672, 1798<br />
Cohen, S M ............. 668*, 1397, 1502*, 1505<br />
Cohen Hubal, E A ................................1339*<br />
Cohen-Hubal, E ...................................... 378<br />
Colangelo, J L .................................. 520, 532<br />
Colatsky, T ............................................... 537<br />
Colby, G ................................................. 1706<br />
Cole, T B ........................................968, 1949*<br />
Coleman, M ............................................768*<br />
Colet, J M ................................................. 519<br />
Colin-Barenque, L .................................. 608<br />
Collard, W ............................................. 1916<br />
Colleton, C ............................................. 1425<br />
Collette, W W .......................................... 515<br />
Collier, A C .................................... 958, 1009<br />
Collier, F ................................................. 2109<br />
Collins, B ...............................................1252*<br />
Collins, B J ............................................... 829<br />
Collins, J ................................................... 121<br />
Collins, J F ............................................ 2111*<br />
Collins, M .............................................. 1373<br />
Collins, M D ...........................................1168<br />
Colman, J ................................................. 155<br />
Colombo, M .........................................2293*<br />
Colosio, C .............................................. 1888<br />
Colvin, V .................................................. 703<br />
Colvin, V L .............................1*, 1862, 2185<br />
Commissaris, R ......................................602*<br />
Compton, D ............................................. 798<br />
Conde-Moo, P C ..................................1875*<br />
Congdon, W ............................................ 492<br />
Conklin, D J ..........................................1844*<br />
Conlon, D ................................................ 462<br />
Connelly, M ........................................... 1856<br />
Conner, A ................................................931*<br />
Conner, M W ..............................................8*<br />
Connolly, T ...............................................114<br />
Conolly, R ......................................... 30*, 34*<br />
Conolly, R B ......... 344, 403, 404, 1297, 1304<br />
Constable, J D ....................................... 2072<br />
Constable, P D ........................... 1310, 1312,<br />
.............................................. 1314, 1315, 1929<br />
Contrera, J .............................................. 2204<br />
Conway, h ...............................................934*<br />
Coogan, T P ............................................. 268<br />
Cook, J C ................................................ 1802<br />
Cook, J D ................................................ 1262<br />
Cook, P M .............................................. 2254<br />
Cooke, G .................................................. 568<br />
Cooke, P S ................................................ 554<br />
Cooney, A J ............................................ 1969<br />
Cooper, K L .......................................... 1167*<br />
Cooper, K R ................................. 1965, 2239<br />
Cooper, R L ....................... 1118, 1728, 1733*<br />
Cooper, S .....................................1252, 2141*<br />
Copeland, C ............................................ 889<br />
Copeland, L ........................................... 1213<br />
Copeman, C ..........................476, 477*, 479,<br />
...................................................840, 841, 1102<br />
Corbeil, J .................................................1103<br />
Corbett, A H ...........................................656*<br />
Corcoran, G B ........................................ 2301<br />
Corley, R ................................................ 1256<br />
Corley, R A ..............................347, 857*, 866<br />
Cornwell, P D ...................................56*, 589<br />
Corsini, E ....................................1888*, 2247<br />
Corson, N ........................................ 443, 698<br />
Corsten, C .............................................. 2050<br />
Corthals, S M ..................................751*, 752<br />
Corton, J C ..........57, 58, 59*, 581, 582, 2286<br />
Cortright, K ..........................................1561*<br />
Cortvrindt, R .............................. 1123, 1366*<br />
Cory-Slechta, D ....................................... 645<br />
Cory-Slechta, D A ............... 217, 1957, 1958<br />
Coryell, V H ...........................................158*<br />
Cosenza, M .............................................. 467<br />
Cosenza, M E ........................................ 1784<br />
228<br />
Cosio, M G ..............................................920*<br />
Costa, D L ...................... 433, 441, 927, 1447<br />
Costa, L G .............................. 967, 968, 1949<br />
Costa, M ..............................1143, 1144, 1789<br />
Coston, T S ............................................ 2193<br />
Couch, L H .........................502*, 1565, 2187<br />
Coudouel, H ............................................ 487<br />
Coulombe, R A ............................ 1407, 1795<br />
Courcol, M ............................................. 2131<br />
Couroucli, X I .......................................1845*<br />
Courson, D L ........................................1883*<br />
Courter, L A ..........................................2271*<br />
Courtney, C ............................................. 529<br />
Coussement, W ....................................... 268<br />
Cover, C ....................................................63*<br />
Covington, C Y ..................................... 1003<br />
Covington, T R .......................350, 847*, 854<br />
Cowan, G S .............................................. 355<br />
Cowell, S ................................................ 1747<br />
Cowlen, M S ...........................................465*<br />
Cox, C ....................................................... 860<br />
Cozzi, N ................................................. 1897<br />
Cracknell, S ........................................... 2031<br />
Craig, S ................................................... 2012<br />
Craigmill, A ........................................... 1561<br />
Crain, S S ............................................... 2273<br />
Cranson, A B ......................................... 1551<br />
Craven, V ................................................. 409<br />
Crawford, C .......................................... 1813<br />
Crawford, R ........................................... 1868<br />
Crean, C S ................................................ 465<br />
Creasy, D ...................................................... 8<br />
Creech, A C ............................................ 1230<br />
Creim, J A ................................................ 238<br />
Crenshaw, B ...........................................2117<br />
Creppy, E E ............................... 1435*, 1440*<br />
Crespi, C L ............................................. 1556<br />
Crincoli, C M ......................................70*, 81<br />
Crissman, J .............................................. 949<br />
Crissman, J W ......... 1507, 1508, 1509, 1510<br />
Critser, J K ............................................... 546<br />
Crittenden, P L .......................................617*<br />
Crockett, P ............................................. 1628<br />
Crockett, P W ............................................ 33<br />
Cr<strong>of</strong>oot, S ................................................. 949<br />
Cr<strong>of</strong>oot, S D ......................1508, 1509*, 1751<br />
Cr<strong>of</strong>ton, K ...................................... 977, 2039<br />
Cr<strong>of</strong>ton, K M .............................. 1091, 1292,<br />
.................................... 1769, 2057, 2161, 2162<br />
Cr<strong>of</strong>ts, F ................................................. 1464<br />
Cromey, D W ..........................................2119<br />
Crooks, D R ............................................629*<br />
Crosier, R B .............................................. 788<br />
Crossgrove, J S ...................591, 1533, 1534*<br />
Crouch, E ................................................394*<br />
Crouse, C ......................................... 776, 787<br />
Crouse, C L .............................................. 773<br />
Croutch, C R .........................................2034*<br />
Crowell, J ............................................... 1785<br />
Cruzan, G .............................................. 1563<br />
Csanady, G A ......................................... 1241<br />
Csizmadia, V ................................464, 1632*<br />
Cui, D ....................................................2123*<br />
Cui, H ............................................723, 1567*<br />
Cui, Y ............................................ 1565, 2187<br />
Culwell, J ................................................. 473<br />
Cumberbatch, M ........................ 1710, 1711*<br />
Cummings, B S ........................... 1720, 2124<br />
Cunningham, C ...............1259, 1284, 1285*<br />
Cunningham, J R .................................. 1883<br />
Cunningham, M ....................45*, 671, 1855<br />
Cunningham, M L ...........................116, 759<br />
Cunningham-Hill, M ............................. 472<br />
Curran, C P .............................................955*<br />
Curran, I .........................................128*, 568<br />
Curren, R D ..........................................2209*<br />
Currie, R ...............................................1375*<br />
Curry, P T ..............................................1776*<br />
Curry-McCoy, T V ...............................2280*<br />
Curtin, G M ..................................1187, 1786<br />
Cushing, C ............................................... 258<br />
Cutter, G R ............................................. 1009<br />
Cwik, M ................................................. 1235<br />
Cyr, D G ............................... 764, 1651, 1790<br />
D<br />
D’ Angelo, D ........................................... 733<br />
D’Ambrozio, A ................................ 776, 787<br />
D’Souza, S E ............................................ 691<br />
D’Surney, S J .......................................... 2240<br />
Dabisch, P A ...................................788, 794*<br />
DaCosta, S O ..........................................1811<br />
Dai, G ................................1050*, 1766, 1920<br />
Dai, Q ............................................901*, 1043<br />
Dai, X ........................................................ 589<br />
Daigle, H J ............................................2221*<br />
Dail, M B .................................................. 972<br />
Dailey, L ................................................. 1019<br />
Dalgleish, H A ....................................... 1771<br />
Dalmas, D A .........................................1828*<br />
Dalmasso, E ............................................. 532<br />
Dalton, T P ....................227, 955, 1165, 1599<br />
Dalvi, R R ...............................................2112<br />
Daly, D S ................................................ 1003<br />
Damiani, C L ........................................1540*<br />
Damodaran, T V ..................................1952*<br />
Daniel, J .................................................. 1004<br />
Daniels, K .............................................. 1972<br />
Daniels, K K .................................753, 1829*<br />
Daniels, M ................................... 1894, 1896<br />
Daniels, M J ........................................... 1214<br />
Danilenko, D M ...................................... 806<br />
Dankovic, D A ........................................387*<br />
Dano, S D ............................................... 1440<br />
Dan<strong>of</strong>f, E .................................................. 325<br />
Dargent, F ................................................ 470<br />
Dart, R C ...............................................1048*<br />
Dary, C C ....................................... 870, 1298<br />
Dash, B ........................................1283*, 1402<br />
Dashwood, W ....................................... 1814<br />
Dasmahapatra, A K .............................. 2253<br />
Daston, G P ........................................... 1371<br />
Datiri, T ...................................................2112<br />
Daugherty, A ......................................... 1838<br />
Davey, J C ...............................................133*<br />
David, M J ............................................. 1736<br />
David, R ................................................... 264<br />
David, R M ............................................ 1504<br />
David, S H ..............................................992*<br />
Davidson, K A ......................................1480*<br />
Davidson, T ............................................1143<br />
Davidson, T L ....................................... 1144*<br />
Davies, R ................................................ 1903<br />
Davis, A .................................................... 602<br />
Davis, B K .................................... 2079, 2080<br />
Davis, D P ...............................................1190<br />
Davis, G ................................................. 2126<br />
Davis, J ..................................................... 732<br />
Davis, J W ................................................ 302<br />
Davis, K ............425, 493, 1637, 1642, 2159*<br />
Davis, M L ............................................. 2193<br />
Davis, R .................................................... 528<br />
Day, B J ................................................... 1853<br />
Day, K C ..................................................359*<br />
Day, S J ................................................... 1242<br />
De Abrew, K N .......................................105*<br />
de Groot, D M .......................... 1056*, 1057*<br />
de Haar, C .............................................1892*<br />
de Jongh, C M ......................................2199*<br />
de Jouffrey, S ................................. 470, 2300<br />
de la Pena, M ......................................... 1658<br />
de Peyster, A .................................. 515, 1742<br />
De Rosa, C T ............................................ 390<br />
De Schaepdrijver, L M ..........................268*<br />
De Souza, A T ...................................56, 589*<br />
de Villa, F P ............................................270*<br />
De Vizcaya-Ruiz, A .............................. 1455<br />
de Waart, R ............................................ 1051<br />
De Wever, B ................................. 481*, 482*,<br />
............................................. 1188*, 2006, 2009<br />
de Wolff, F A .................................... 606, 634<br />
Dean, J .......................................................24*<br />
Dearman, R ..................................1196, 1201<br />
Dearman, R J ....................... 37*, 1198, 1200,<br />
..................................1204, 1206*, 1207, 1209,<br />
...............................................1710, 1711, 1999<br />
DeBus, S ..................................................1184<br />
DeCaprio, A P ....................................... 1281<br />
Dechkovskaia, A M ........................ 961, 962<br />
DeCrist<strong>of</strong>aro, M F ....................................61*<br />
DeCuir-Charbonnet, C .......................... 356<br />
Defoort, E .............................................2259*<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Degen, D E ............................................ 1847<br />
DeGeorge, G L ...................2011, 2012, 2207<br />
Degitz, S ................................................. 1755<br />
Degitz, S J .................................... 1754, 1756<br />
Degn, L L ............................................... 1942<br />
DeGroot, D .......................................94*, 353<br />
Deguchi, Y ............................................. 1094<br />
Dekant, W ...................................1239*, 1799<br />
Del Razo, L M ................................603, 1132<br />
Delaney, B .............................................. 1405<br />
DelCarpini, J ............................................ 805<br />
Delclos, K B ........................................... 2141<br />
Delgado, V ......................................608, 1153<br />
Delgado-Morales, W ............................ 1893<br />
Delker, D ...................................... 2144, 2146<br />
Dellarco, V L ...........................................672*<br />
Delnomdedieu, M .................................. 540<br />
Delongeas, J ............................................1175<br />
DeLorme, M ...........................................235*<br />
Delorme, M P ........................ 231, 234, 1475<br />
DelRaso, N ...................................... 571, 963<br />
DelRaso, N J ............................................ 526<br />
Demers, P .............................................1667*<br />
Demeter, J .............................................. 1252<br />
Deng, X ...................................................... 69<br />
Denison, M .............................................. 353<br />
Denison, M S .............................94, 95, 106*,<br />
.............................................. 1361, 1752, 2049<br />
Dennis, A O ............................................. 613<br />
Dennis, W E ........................................... 2017<br />
Dennison, J E ......................377, 1473*, 1474<br />
Denoux, G ............................................. 1290<br />
Denslow, N .........................575, 1773*, 2023<br />
Deo, A K ................................................1562*<br />
DeParle, L ................................................ 809<br />
Dere, E ...........................................101*, 1383<br />
Derk, R C ................................................. 549<br />
Dertinger, S D ......................................2212*<br />
Descotes, J ...........................885*, 1240, 2032<br />
Desdouets, C ............................................118<br />
DeSesso, J M .......................................... 2097<br />
Desilets, G ............................................... 174<br />
DeSmet, K .............................................1856*<br />
Destrument, A ....................................... 1710<br />
Detrisac, C ............................................. 1785<br />
Dettbarn, W D ....................................... 1000<br />
Dettmer, K ............................................... 106<br />
Devesa, V ............................148, 1231, 1817*<br />
Devi, S S ................................................1909*<br />
Devine, P J ............................................ 1116*<br />
DeVito, M .................................................. 32<br />
DeVito, M J ....................311, 850, 858, 1227,<br />
.......................... 1250, 1292, 1769, 2057, 2161<br />
Devlin, M K ............................................587*<br />
Devlin, R ..................................... 303*, 1019*<br />
Dewe, W .................................................. 519<br />
DeWitt, J ..................................................889*<br />
DeWoskin, R S ............................. 294*, 859*<br />
Deyo, J A ................................................ 1504<br />
Deyrup, C .............................................. 1386<br />
Dhondt, M ............................................. 2015<br />
Di Giulio, R ..................................687*, 1581<br />
Diaco, M ................................................ 2001<br />
Dial, S ............................................. 762, 1912<br />
Diamond, G L ....................................... 2082<br />
Diawara, M M .......................... 1120*, 1260*<br />
Diaz-Sanchez, D ..................................... 458<br />
DiCicco-Bloom, E ................................. 1058<br />
Dickinson, T ............................................ 362<br />
Dieckmann, G R ................................... 1594<br />
Dieter, M Z ...................564, 815, 821, 1229*<br />
Dietrich, D ...... 2099, 2113, 2114, 2115, 2116<br />
Dietrich, H ............................................. 1269<br />
Dietzel, K ................................................416*<br />
Dijkstra, A ................................................ 953<br />
Dileberto, J J .......................................... 1253<br />
Diliberto, J J .......................... 311, 395, 1227*<br />
Dillman, J F ............................125, 182, 774*<br />
Ding, X ........................................... 723, 1567<br />
Din<strong>of</strong>f, T ................................................... 414<br />
Din<strong>of</strong>f, T M ............................................ 1279<br />
Dion, C ..........................................1127, 1128<br />
Dionnet, F ................................................ 446<br />
DiPalma, K ............................................ 1532<br />
Dive, C ..................................................1652*<br />
Divine, K K ................................. 1141*, 1142<br />
Diwan, B ........................ 138, 144, 694, 1608<br />
Dix, D ..................................................... 2145<br />
Dix, D J .......................188, 644*, 1709, 2143,<br />
.............................................. 2148, 2150, 2151<br />
Dixit, R .............................................7A*, 7B*<br />
Dixit, R M .................................................... 9<br />
Dixon, D ........................................1114, 1794<br />
Dnyanmote, A V ..................62, 1910, 2139*<br />
Dobbs, J A ................................................ 972<br />
Dobson, A ................................................ 486<br />
Dodge, D .................................................248*<br />
Doehmer, J ............................................. 1814<br />
Doerfler, D L .......................................... 1715<br />
Doerge, D R ..................293*, 361, 502, 1565<br />
Doerr, C L ................................................ 152<br />
Doherty, C M ........................................2027*<br />
Doherty, J ................................................. 977<br />
Doi, A M ................................................1800*<br />
Doi, K ..................................................... 1433<br />
Doi, Y .......................................................746*<br />
Dolinoy, D C ...........................................572*<br />
Doll, M A ..................................... 1265, 1266<br />
Domann, F E ........................................... 147<br />
Domico, L M ........................................1965*<br />
Dominick, M A ...................................... 1781<br />
Dommels, Y ........................................... 1319<br />
Domoradzki, J ....................................... 1256<br />
Domotor, S ..............................................332*<br />
Donahower, B ..........................................68*<br />
Donaldson, K .......................................... 437<br />
Dong, J .................................................. 2118*<br />
Dong, W ................................................. 2037<br />
Donhue, J ..............................................2100*<br />
Donnell, B .............................................. 1783<br />
Donnelly, K .................................... 524, 1290<br />
Donnelly, K C .............................. 1593, 2270<br />
Donohue, T M ............................1657*, 2280<br />
Donovan, J C ........................................1356*<br />
Doolittle, D J ................................ 1516, 1786<br />
Doorn, J A ...................185, 209, 1718, 1723*<br />
Dopp, E ..................................... 1818*, 2225*<br />
Doran, S ................................................. 1383<br />
Dorman, D ............................................... 863<br />
Dorman, D C ..................................675*, 940<br />
Dormans, J ............................................. 1490<br />
Dormans, J A ......................................... 1446<br />
Dorr, E .....................................................2116<br />
Dorsch, L M ............................................. 774<br />
Dorsey, A ................................................ 2086<br />
Doshi, M .................................................. 715<br />
Doshi, U ................................................... 934<br />
Dougherty, E ............................................. 86<br />
Dourson, M ........................................... 2094<br />
Dourson, M L ........................................ 1343<br />
Downend, A B ......................................... 534<br />
Doyle, A E ...................................1263*, 1272<br />
Doyle, E ................................................... 733<br />
Doyle, M .........................................930, 942*<br />
Draaisma, A L ....................................... 1913<br />
Dragan, Y ............563, 671, 762, 1029*, 1912<br />
Dragan, Y P ............................511, 666, 1704<br />
Dragin, N ................................................. 955<br />
Drake, V J .............................................2246*<br />
Draper, R K ............................................ 1594<br />
Dreher, K ...............................................1444*<br />
Dreiem, A ................................................621*<br />
Drobna, Z ................................................148*<br />
Drolet, D .................................................. 244<br />
Drupa, C .................................................532*<br />
Dryzga, M .............................................. 1256<br />
Duan, J ........................................... 741, 1500<br />
Dubois, E ............................................... 1843<br />
Duchesne, M ......................................... 2131<br />
Duchesneau, M ....................................... 174<br />
Duffy, C .................................................... 754<br />
Duffy, J ..................................................... 893<br />
Dugan, C M ............................................... 69<br />
Duirk, S E .............................................. 2065<br />
Dumas, P ............................................... 2156<br />
Dumont, J .............................................1039*<br />
Dunaway, S ............................................. 892<br />
Duncan, B .............................................. 1593<br />
Dunlea, S ............................................... 1700<br />
Dunn, C .............................................. 57, 581<br />
Dunn, R T .............................................1784*<br />
Dunnick, J .....................................828, 1826*<br />
Dunnick, J K ............................................ 829<br />
Dunsmore, M .........................................1151<br />
Dunstan, R ............................................. 1916<br />
Dupin-Roger, I ........................................ 470<br />
up-to-date information at www.toxicology.org 229<br />
Durham, J A ........................................... 1237<br />
Durhan, E J ............................................ 1746<br />
Duydu, Y ............................................... 1273<br />
Duzevik, E G ........................................ 1135*<br />
Dwivedi, J ................................. 1591*, 1592*<br />
Dybing, E ......................................... 307, 385<br />
E<br />
Earl, L ....................................................... 528<br />
Earl, L K ..................................................249*<br />
Easter, M D .............................................418*<br />
Easterling, M ..........................................852*<br />
Eastvold, M ................................. 1740, 2066<br />
Eaton, D L .............................................. 1495<br />
Echeverria, D .......................................1275*<br />
Eckel-Passow, J E .................................. 1382<br />
Edelhauser, H F ...................................1623*<br />
Edge, D T ................................................976*<br />
Edmond, C .............................................. 540<br />
Edward, D ............................................... 715<br />
Edwards, B ............................................ 1568<br />
Edwards, C N ....................................... 1390<br />
Edwards, J A .......................................... 1429<br />
Edwards, P A ..........................................288*<br />
Edwards, T R ........................................... 473<br />
Eells, J T ....................................... 1856, 2245<br />
Egan, B ..................................................... 109<br />
Ehlich, A ................................................. 1996<br />
Ehman, K D ..........................................1078*<br />
Ehresman, D .....................1236*, 1740, 2066<br />
Ehrich, M ......................161, 316*, 600, 1943<br />
Ehrich, M F .................................... 626, 1944<br />
Eiland, E ................................................. 2240<br />
Ekins, S ........................................1377*, 1378<br />
Eklund, C ................................................. 864<br />
Eklund, C R ..................................856*, 2089<br />
Ekman, D ............................................... 1709<br />
Ekpo, B ................................................... 1439<br />
El-Kadi, A O ...........................................1154<br />
El-kholy, H ........................ 1139, 1140, 1384*<br />
El-Masri, H ............................................ 1560<br />
El-Masri, H A .......................................... 390<br />
El-Masry, E M ......................................1620*<br />
El-Salanti, Z ........................................... 1390<br />
El-Tawil, O S .............................................79*<br />
Elbekai, R H ......................................... 1154*<br />
Elcombe, B ............................................... 277<br />
Elcombe, C ...................277*, 733, 761, 2258<br />
Eldan, M ...............................................1505*<br />
Elder, A ............................................443*, 698<br />
Elder, A P ................................................. 449<br />
Elder, E J .................................................1176<br />
Eldridge, J C .......................................... 1738<br />
Elfarra, A A .................................1572*, 2262<br />
Elferink, C J ..................................994*, 1362<br />
Elizondo-Azuela, G .............................. 2166<br />
Ellinger, H ..............................................2114<br />
Ellinger-Ziegelbauer, H ....................... 1735<br />
Ellis, J .....................................................2264*<br />
Ellis, M E .......................................184, 1216*<br />
Ellis, R s .................................................. 1887<br />
Ellis-Hutchings, R ...............................1087*<br />
Elnabawi, A M ........................................ 632<br />
Elsayed, N ..............................................767*<br />
Elskus, A A .............................................. 957<br />
Eltom, S E .............................................. 1810<br />
Ema, M ..........................................281*, 2155<br />
Emberley, J ..................................... 367, 1869<br />
Emberley, J K ......................992, 1870, 2288*<br />
Emeigh Hart, S ................................ 173, 508<br />
Emeigh Hart, S G ..................................... 11*<br />
Emeny, R T .............................................189*<br />
Enayetallah, A ......................................1924*<br />
End, P ......................................................... 61<br />
Engel, L S ............................................... 1333<br />
Engelhardt, S ........................................... 165<br />
Ennulat, D ....................................... 173, 536<br />
Eom, J H ................................................... 907<br />
Eppley, R M ................................. 1314, 1315<br />
Eremenko, A V ........................................ 192<br />
Erickson, J E ............................................ 462<br />
Erikson, K M ........................................... 599<br />
Eriksson, J .............................................. 2062<br />
Eriksson, P ...................... 312, 405, 974, 975,<br />
.............................................1073, 1074*, 2062<br />
Erler, J T ................................................. 1652<br />
Ernstgard, L ..................................868, 1248*<br />
Ershaw, K ................................................. 824<br />
Esch, H L ...............................................2058*<br />
Eskes, C ...........................................664*, 665<br />
Espandiari, P ......................263*, 1513, 1842<br />
Espejo, A ................................................ 1004<br />
Espiritu, I ............................................... 1013<br />
Ettinger, B .............................................. 1467<br />
Ettinger, R .............................................. 2073<br />
Euling, S ................................................... 378<br />
Euling, S Y ..............................................255*<br />
Evan, G .................................................. 1584<br />
Evans, B R .............................................1359*<br />
Evans, G ................................................... 824<br />
Evans, M G .............................................. 530<br />
Evans, M V ...................856, 858*, 864, 2089<br />
Evans, R ........................................... 776, 787<br />
Evans, R A ....................................... 773, 775<br />
Evans, R M ........................................ 65, 137<br />
Evans, T J ...................................... 546*, 1151<br />
Evansky, P ............................................... 927<br />
Evansky, P A ............................................ 448<br />
Everds, N E ........................................... 1405<br />
Everett, D ................................................247*<br />
Everitt, J ..................................................... 59<br />
Evrard, Y ................................................ 1897<br />
Eynon, B ................................................. 1700<br />
F<br />
Factor, S A .............................................. 1988<br />
Fahl, W ..................................................... 817<br />
Fail, P A .................................................... 547<br />
Fairchild, D .............................................. 801<br />
Fairley, K J ............................................1210*<br />
Falahatpisheh, H .................................. 2132<br />
Falduto, M T .............................................. 45<br />
Falgout, M M ...............................1141, 1142<br />
Falk, M ..................................................... 374<br />
Falk Filipsson, A ..................................... 405<br />
Faller, T H .............................................. 1241<br />
Falluel-Morel, A .................................... 2300<br />
Fan, A ....................................................2105*<br />
Fan, J ....................................................... 1378<br />
Fan, R ....................................... 896, 897, 900<br />
Fang, H .............................. 1098, 1099, 1704<br />
Fangman, T J ........................................... 546<br />
Fanucchi, M ................................1648*, 1891<br />
Fanucchi, M V ................................. 359, 916<br />
Farah, V ..................................................791*<br />
Fare, T L ................................................... 121<br />
Farin, F M .............................................. 1275<br />
Fariss, M W ............................................. 206<br />
Farland, W H .................................32*, 1695<br />
Farmer, J D ................................... 1437, 1438<br />
Farooqui, M Y ......................................1577*<br />
Farraj, A ................................................. 1714<br />
Farraj, A K ...............................................448*<br />
Farrar, D ................................................... 277<br />
Farrer, D G ..................................1877, 1884*<br />
Fastje, C D ............................................... 936<br />
Faulconer, L ............................................365*<br />
Faulkner, D ............................................ 2182<br />
Faure, L .................................................. 1240<br />
Faustman, E ......................1291, 1303, 1655*<br />
Faustman, E M .....................346, 1155, 2257<br />
Fausto, N ................................................. 813<br />
Fay, M ..........................................1481*, 1483<br />
Fay, M J ........................................ 1436, 1602<br />
Fears, R .................................................. 2109<br />
Fechter, L D ........................................... 2182<br />
Fechter, L D ..............................................50*<br />
Fedor, M ................................................... 537<br />
Fedoruk, M J ..........................................412*<br />
Fehling, K ................................................ 410<br />
Feldman, R .............................................. 374<br />
Feldman, R A .......................................... 576<br />
Felice, J A ................................................. 473<br />
Fellows, K ................................................ 860<br />
Felty, Q ..................................................1774*<br />
Fenaux, J .................................................. 887<br />
Feng, X ..................................................2291*<br />
Fennell, S ..............................................1780*<br />
Fennell, T ................................................505*<br />
Fennell, T R ............................................. 361<br />
Fent, G M .............................................. 1151*<br />
Fenton, S ....................................... 297*, 299*
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Fenton, S E ....................................1122, 1369<br />
Ferdinandi, E ......................................... 1780<br />
Ferguson, D ........................................... 2039<br />
Ferguson, J ................................................. 10<br />
Fernandes, A ........................................... 681<br />
Fernandez, C ......................... 225, 813, 1859<br />
Fernandez, G E ....................................1385*<br />
Fernandez, S ............................................ 196<br />
Fernandez Canton, R ..........................1748*<br />
Fernando, R ........................................... 1252<br />
Ferrell, J M ....................................1119, 1728<br />
Fetter, B .................................................... 272<br />
Feuers, R J ................................................ 355<br />
Feuston, M ..........................................7A, 7B<br />
Fickert, P .................................................... 63<br />
Fielden, M .....................126, 521*, 522, 1700<br />
Fielden, M R ............................................ 353<br />
Fields, C J ................................................284*<br />
Filipov, N M .............617, 1947, 1955*, 1956<br />
Filser, J G ................................................ 1241<br />
Finco-Kent, D .......................................... 171<br />
Finke, K L ................................................ 782<br />
Finkelstein, J ............................................ 443<br />
Finkelstein, J N ......................................306*<br />
Finley, B ..........................................392, 409*<br />
Fiore, M .................................................. 1799<br />
Firat, H ....................................................... 61<br />
Fisch, C .........................................470*, 2300<br />
Fischer, C ................................................975*<br />
Fishel, J ..................................................... 169<br />
Fisher, J ................................... 416, 968, 2039<br />
Fisher, J W .............402, 847, 861, 869*, 2095<br />
Fisher, M .................................................363*<br />
Fisher, R L .............................................. 1914<br />
Fiskum, G .............................................. 1960<br />
Fitsanakis, V A .......................................599*<br />
Fitzgerald, S D ........................................ 534<br />
Fitzsimmons, P N ......................1579*, 1580<br />
Flagler, N ................................................. 779<br />
Flaherty, J M ............................................ 230<br />
Flanagan, B ...........................................1207*<br />
Flanders, J A .......................................... 2303<br />
Flaskos, J ................................................ 1950<br />
Flaws, J ................................ 1111, 1112, 1960<br />
Flaws, J A ...................422, 1109, 1260, 1367,<br />
............................................. 1811, 1823*, 2153<br />
Fleeman, T L ...................................273, 1121<br />
Fleener, S .................................................. 272<br />
Fleischmann, K ..................................... 1905<br />
Fletcher, G .............................................. 1468<br />
Flick, B ....................................... 2251*, 2252*<br />
Flickinger, G .......................................... 1717<br />
Flisher, A ................................................ 1334<br />
Flockton, A ............................................ 2243<br />
Florea, A M .................................. 1818, 2225<br />
Florence, R L ...........................................1125<br />
Floyd, H S .............................................1792*<br />
Flynn, C A ................................................ 979<br />
Flynn, E J ............................................... 1948<br />
Foertsch, L ..............................................1198<br />
Foertsch, L M ........................................ 1371<br />
Fogle, C M ............................................. 1072<br />
Fogleman, J ............................................ 1418<br />
Fogleman, J L .......................................2029*<br />
Fokkens, P H ........................................... 929<br />
Foley, J ...................................................... 757<br />
Foley, J F ................................. 784, 829, 1821<br />
Follansbee, M H ...................................... 399<br />
Fomby, L ...................................... 2035, 2070<br />
Fomby, L M ..........................................1425*<br />
Fong, C J .....................................1382, 1760*<br />
Forbes, A .................................................. 968<br />
Forbes, P D ...................................... 10, 2193<br />
Ford, S M ................................................324*<br />
Foreman, B D .........................................213*<br />
Forgash, R C .......................................... 1514<br />
Forkert, P ....................................... 730, 2278<br />
Foroozesh, M .......................................... 356<br />
Forrest, J N ............................................ 1706<br />
Forster, J ................................................... 793<br />
Forster, J S ................................................ 788<br />
Forster, R ................................ 265, 838, 2300<br />
Fort, D J .................................................1758*<br />
Fortoul, T I .................................... 608, 1153*<br />
Fostel, J ................................................... 1709<br />
Fostel, J M .................................................. 64<br />
Foster, N ................................................... 493<br />
Foster, P .................................................... 551<br />
Foster, P M ............................................... 681<br />
Foster, R T .............................................. 1255<br />
Foster, W ........................................ 928, 1846<br />
Foster-Brown, L .................................... 1843<br />
Foth, H ..................................................1461*<br />
Fouad, H ................................................ 1076<br />
Foulon, O ................................................265*<br />
Foureman, G L ........................................ 388<br />
Fournier, A ............................................. 2300<br />
Fowler, B ................................................ 1823<br />
Fowler, B A ................. 390, 1156, 1159, 1189<br />
Fox, D ............................................. 500, 1206<br />
Fox, D A ..............................429, 1060*, 1061<br />
Fox, S ........................................................ 528<br />
Foxenberg, R J ............................2038*, 2157<br />
Frame, S R ............................................... 952<br />
Frampton, N ............................................ 272<br />
Francis, J .................................................. 932<br />
Frank, S .................................................. 1557<br />
Franklin, P ............................................... 492<br />
Franks, S .................................................345*<br />
Frantz, S ................................................. 1916<br />
Frantz, S W .............................................. 808<br />
Franzosa, J A ......................................... 2245<br />
Frazer, D ........................................ 933, 1468<br />
Frazier, L .....................................1664, 1665*<br />
Fredriksson, A ........................ 312, 405, 974,<br />
................................................ 975, 1074, 2062<br />
Freed, B M ............................................. 1865<br />
Freed, W J ................................................ 629<br />
Freeman, J J ........................................... 1514<br />
Freeman, M ............................................. 817<br />
Freeman, R .............................................. 428<br />
Freidig, A ....................................1560*, 2087<br />
Freitag, D G ..........................................1255*<br />
French, J E .....................................500, 1044*<br />
Freney, E .................................................. 437<br />
Freudenrich, T M .................................. 2057<br />
Freyberger, A ......................................... 1735<br />
Friderichs-Gromoll, S ....... 168, 1105, 1636*<br />
Frieauff, W ............................................... 336<br />
Fried, K W ................................ 2048*, 2050*<br />
Friedman, M .................................. 398, 1039<br />
Friedman, M A ........................................ 505<br />
Friedman, S L ........................................ 1913<br />
Friedrichs, B ............................................ 922<br />
Frings, W ................................................167*<br />
Friry-Santini, C ....................................1731*<br />
Fritz, L K .................................................. 238<br />
Fritz, W A ...............................................550*<br />
Froehlich, J ............................................. 1236<br />
Froget, G .................................................. 838<br />
Fromer, D B ........................................... 1665<br />
Frueh, F ...........................................29*, 1381<br />
Fruen, B R .............................................. 2053<br />
Fryar, E ..................................................1783*<br />
Fu, P P .......................................... 1565, 2218<br />
Fu, X ............................................. 2141, 2285<br />
Fuchsbichler, A ......................................... 63<br />
Fuciarelli, A ............................................1181<br />
Fuciarelli, A F .......................................... 506<br />
Fuentes-Mattei, E ........................445, 1893*<br />
Fuerst, P ................................................. 2072<br />
Fuhrman, K ........................................... 1943<br />
Fujii, Y .................................................... 2297<br />
Fujimoto, S .............................................. 121<br />
Fujiwara, M ............................................. 954<br />
Fukuda, I ............................................... 1379<br />
Fukuda, M ............................................. 1703<br />
Fukushima, S .......................... 742, 746, 750<br />
Fukushima, T ...............129*, 531, 543, 1899<br />
Fukushima, Y .......................................... 544<br />
Fukuto, J M .............................................1168<br />
Fukuzaki, K ................... 496, 826, 833, 1094<br />
Fullard, M .............................................. 1973<br />
Funatake, C J ........................................1873*<br />
Fung, W ................................................. 2195<br />
Furlong, C E .................................. 968, 1949<br />
Furnes, B .................................................. 739<br />
Furr, J .................................. 1374, 1743, 1744<br />
Furuhama, K ................................... 267, 812<br />
Furuhashi, K ..........................................278*<br />
Furukawa, E .................................... 175, 631<br />
Furukawa, T ............................................ 708<br />
Fuscoe, F C ............................................ 1381<br />
Fuscoe, J C ............................121, 563*, 2222<br />
230<br />
G<br />
Gadagbui, B ................................. 1477, 2094<br />
Gagne, P V ............................................. 1556<br />
Gagnon, N ............................................... 244<br />
Gaido, K W .......................... 276, 1372, 1729<br />
Galambos, E S ....................................... 1784<br />
Galbert, L ............................................... 1042<br />
Gales, T L ................................................. 536<br />
Galinsky, R .............................................. 325<br />
Gallagher, E P ........................................ 2244<br />
Galli, C L .....................................1888, 2247*<br />
Galliard, N ....................................... 203, 480<br />
Gallicchio, L ............................................ 422<br />
Gallo, M A ............................................... 721<br />
Galloway, S .........................................7A, 7B<br />
Gallucci, R ............................................2182*<br />
Gammon, D W .............................283, 2152*<br />
Gandelsman, V Z ................................... 701<br />
Gandolfi, A .............................................1161<br />
Gandolfi, A J .................................... 146, 147<br />
Gandy, J ...........................................424*, 706<br />
Ganem, G ............................................... 1095<br />
Ganey, P E .............................. 69, 1930, 2052<br />
Ganley, K ............................................... 1632<br />
Gannon, S ...............................................236*<br />
Gannon, S A ................................ 1578, 1686<br />
Ganter, B .........................................126, 514*<br />
Gantt, J A ............................................... 1702<br />
Gao, D .....................................................895*<br />
Gao, J .......................................................892*<br />
Gao, S ..............................................574*, 941<br />
Gao, X ....................................................... 542<br />
Gaoua, W ................................................. 265<br />
Garabedian, C ....................................... 1275<br />
Garcia, H D ........................................... 1149*<br />
Garcia, R .................................................. 427<br />
Garcia, S J ........................................595*, 599<br />
Garcia-Arenas, G .................................... 253<br />
Garcia-Chavez, E ...................................603*<br />
Garcia-Vargas, G ..................................... 253<br />
Garcia-Vargas, G G ................................252*<br />
Gardinali, P ........................................... 1588<br />
Gardner, C ............................................1054*<br />
Gardner, J ....................................... 246, 1898<br />
Garg, R ................................................... 1294<br />
Gargas, M ........................................ 233, 240<br />
Gargas, M L .................... 231, 232, 234, 235,<br />
............................................ 236, 237, 238, 347<br />
Garino, M .............................................. 1780<br />
Garner, C .......................................732*, 1252<br />
Garner, C D ........................1185, 1187, 1516<br />
Garrett, C M .......................344, 2178*, 2179<br />
Garrett, M .............................................. 1973<br />
Garrett, R ..............................................1867*<br />
Garrett, S H .................................616*, 1606,<br />
.............................................. 1614, 1616, 1618<br />
Garrett-Engele, P .................................... 287<br />
Garrick, M D ..........................................1144<br />
Garrison, A ............................................ 1082<br />
Garry, M ................................................1387*<br />
Gartner, T ..............................................1642*<br />
Garza-Ocanas, F ................................... 1412<br />
Garza-Ocanas, L ................................... 1412<br />
Gasiewicz, T A ........ 84, 97, 555, 1867, 2046<br />
Gatlin, C L ............................. 64, 1005, 1900<br />
Gatto, G J ................................................. 471<br />
Gauger, K ............................................... 1775<br />
Gauger, K J ...........................................1741*<br />
Gauthier, C ............................................ 2135<br />
Gautier, J .........................................114, 2131<br />
Gavett, S H .......................... 448, 1714, 1715<br />
Gaviola, B ................................................ 793<br />
Gaviola, B P ..................................... 775, 788<br />
Gearhart, C A ............................................ 50<br />
Gearhart, J ..............................................785*<br />
Gearhart, J M ....................... 786, 1305, 1719<br />
Gebhart, A ..................................2101*, 2104<br />
Gehman, E ............................................. 1998<br />
Geiss, K T ............................................... 1719<br />
Gelbke, H ............................................... 1563<br />
Gelein, R .......................................... 443, 698<br />
Gelein, R M .............................................. 223<br />
Gelinas, C ................................................ 195<br />
Gelineau-van Waes, J B ...............684*, 1396<br />
Gellein, K ................................................. 595<br />
Geller, A ................................................... 858<br />
Geller, A M .......................1942*, 2088, 2093<br />
Gelzleichter, T R ....................................806*<br />
Gemzik, B .............................................. 1768<br />
Genell, C .................................................. 873<br />
Genell, C A .............................................. 179<br />
Geng, W ................................................... 872<br />
Gennings, C .................................... 389, 408,<br />
.........................1292*, 1382, 1759, 1934, 2161<br />
Gensburg, L ........................................... 1093<br />
Genter, M ................................................. 103<br />
Gentry, P .................................................. 350<br />
Gentry, R .................................................. 261<br />
Geoly, F .................................................... 540<br />
Georg, G I .............................................. 2048<br />
George, M .................................... 2144, 2146<br />
George, O ............................................... 1736<br />
George, S M ..........................................1710*<br />
Georgieva, N I ........................................523*<br />
Gephart, L A .......................................... 1480<br />
Gerberick, F ..............1196, 1198, 1201, 1999<br />
Gerberick, F G ........................................1197<br />
Gerecke, D R ................................780*, 2171<br />
Gerin, M ................................................... 244<br />
Gerl, M ..................................................... 510<br />
Gerl<strong>of</strong>s-Nijland, M E ...................929, 1446*<br />
Germer, S ..............................................2061*<br />
Germolec, D R ................... 5, 362, 878, 1212<br />
Gerson, R ............................................... 2210<br />
Gettings, S D ......................................... 1631<br />
Ghanayem, B ........................................... 732<br />
Ghanayem, B I .....................361*, 728, 1794<br />
Ghanem, M M ........................................360*<br />
Ghantous, H .........................................1995*<br />
Ghio, A J ..................................................640*<br />
Ghosh, D .................................................. 622<br />
Giavini, E ............................................... 2247<br />
Gibbons, D R ........................................... 357<br />
Gibbs, A C ...............................................538*<br />
Gibson, A B ............................................ 1585<br />
Gibson, D P ........................................... 2209<br />
Gibson, G ................................................. 580<br />
Gibson, J E ............................................2227*<br />
Giddabasappa, A .................................. 1061<br />
Giddings, A M ...................................... 2160<br />
Gideon, K M ............................................ 919<br />
Giera, S ................................................... 1741<br />
Gies, R A .................................................1150<br />
Gieseke, C ............................................. 1115*<br />
Giesy, J P ................................................ 2150<br />
Gigliotti, A ............................................... 455<br />
Gil, J .......................................................... 907<br />
Gilbert, K ................................................. 172<br />
Gilbert, M E ............................................982*<br />
Gilbert, S G ............................................ 1678<br />
Gildea, L ............................................... 1198*<br />
Gilkison, I .............................................1466*<br />
Gill, S S ....................................................... 59<br />
GIllam, M P ............................................. 987<br />
Gillardeaux, O ................................ 560, 577<br />
Gillespie, A .............................................524*<br />
Gillespie, A M ....................................... 2270<br />
Gillies, P ....................................................40*<br />
Gillilland, C ........................................... 2098<br />
Gilman, M S ................................. 273, 1121*<br />
Gilmour, I .................................... 1214, 1894<br />
Gilmour, M ..............308*, 639*, 1015*, 1896<br />
Gilmour, P S ............................................ 441<br />
Gilmour, S .............................................. 1514<br />
Gilotti, A C ............................................2012*<br />
Ginsberg, G ........................................... 1978<br />
Ginsburg, D ................................1512, 2267*<br />
Gioda, A ........................................445*, 1893<br />
Giordano, G ............................................. 967<br />
Giroux, C ............................................... 1377<br />
Giroux, C N ..........................................1378*<br />
Giulivi, C ............................................... 1717<br />
Gladen, B C ........................................... 1333<br />
Glass, D F ..............................................1479*<br />
Glauert, H P ................................ 1487, 1488<br />
Glaze, E .........................................466*, 1782<br />
Glaze, E R .......................... 1776, 1777, 1778<br />
Glenn, A E .............................................. 1395<br />
Glenn, K ....................................... 1404, 1671<br />
Glesne, D A ............................................ 1035<br />
Glynn, P ....................................... 1938, 1967<br />
Go, Y ......................................................... 820<br />
Goad, J ..................................................... 809<br />
Gobbers, E .................................. 1123*, 1366<br />
Godard, C ................................................ 487<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Godin, S J ......................................850*, 1250<br />
Godwin, D ............................................... 325<br />
Goedken, M ........................................... 1051<br />
Goering, P L .......................................... 2136<br />
Goetz, A K ........................2143, 2148*, 2151<br />
Gogal, R M .............................................887*<br />
Gogvadze, V .......................................... 2276<br />
Gohlke, J M .............................................346*<br />
Goins, S .................................................... 103<br />
Gold, A ........................................... 500, 1847<br />
Gold, E P ............................................... 1101*<br />
Gold, P W .......................... 1776, 1777, 1778<br />
Goldberg, B B ........................................ 1742<br />
Goldman, J M ............................... 547, 1119*<br />
Goldsmith, T ......................................... 1468<br />
Goldstein, D A .....................................1344*<br />
Goldstein, R A ......................................... 532<br />
Goldston, T ............................................ 1309<br />
Goldsworthy, T L .................................. 1302<br />
Golka, K ......................................1264, 1269*<br />
Gollapudi, B .................................2211, 2224<br />
Gollapudi, B B ............................... 585, 1041<br />
Goncharova, T ...................................... 2206<br />
Gong, B ...................................................825*<br />
Gonsebatt, M E ....................................... 139<br />
Gonzales, C ..................................1160, 2071<br />
Gonzalez, B ........................................... 2300<br />
Gonzalez, I ............................................... 576<br />
Gonzalez-Villalva, A .....................608, 1153<br />
Gooderham, N J .................................... 2264<br />
Goodfellow, G H ................................... 1408<br />
Goodin, M G ........................................... 707<br />
Goodman, J ..................................982, 1270*<br />
Goodman, J I ......................669, 1786, 1787*<br />
Goodsaid, F ........................................... 1381<br />
Goodwin, S ............................ 93, 2044, 2056<br />
Goodyear, A W ....................................... 504<br />
Gooler, D M ........................................... 1085<br />
Goozner, M ...........................................1682*<br />
Gopee, N V .........................502, 2185, 2187*<br />
Gopinathan, L ..........................................54*<br />
Gorbunov, N ........................................... 767<br />
Gordh, T ................................................. 1073<br />
Gordon, C J ...........................................2092*<br />
Gordon, J D ................................1752*, 2049<br />
Gordon, M K ........................................... 780<br />
Gordon, N ..............................................1145<br />
Gordon, T ...............................303, 305, 1129<br />
Gore, E R .................................................166*<br />
Gore, L ...................................................... 173<br />
Gorelik, O ........................................ 701, 702<br />
Gorman, N ............................................... 218<br />
Goshe, M B ............................................ 1702<br />
Gosselin, S J ................................. 1641, 2031<br />
Goto, K ....................................................267*<br />
Goto, T ................................................... 1928<br />
Gould, S ................................................... 824<br />
Gould, T ................................................. 1453<br />
Gowdy, K M .........................................1896*<br />
Gower, J K ............................................... 166<br />
Goytia-Acevedo, R ................................253*<br />
Graf, M L ................................................. 905<br />
Graff, D .................................................. 1450<br />
Graff, J E ................................................ 1091<br />
Graham, B ................................................ 508<br />
Graham, D L .........................................1544*<br />
Graham, J ................................................. 210<br />
Graham, S A ............................................ 987<br />
Graham, S L ........................................... 2265<br />
Graham, T ...............................................2112<br />
Grainger, S .........................463*, 1106, 1173*<br />
Gralinski, M ............................................ 839<br />
Grandjean, P .......................................... 1055<br />
Grant, D ................................................. 1924<br />
Grasman, K A .......................................... 888<br />
Grasty, R C ............................................1647*<br />
Graves, S ....................................... 391*, 1181<br />
Graves, S W ......................... 194, 1233, 1234<br />
Gray, C A .................................................... 44<br />
Gray, D T ............................................... 1110*<br />
Gray, J ..................................................... 1537<br />
Gray, J P ..................................54, 217, 1398*<br />
Gray, L E ...........................1374, 1743, 1744*<br />
Graziano, M ............................................ 529<br />
Greaves, P ...............................................1110<br />
Green, J L ............................................... 1048<br />
Green, S .................................................. 1945<br />
Green, T ................................... 743, 744, 745<br />
Greene, A L ............................................ 1717<br />
Greenfeld, C .................................1109, 1367<br />
Greenlee, A R .........................................682*<br />
Greenwell, R J ......................................... 686<br />
Gregory, G S ............................................ 797<br />
Gregus, Z ........................................140, 149*<br />
Greim, H ................................................ 1241<br />
Griffin, D .................................................. 493<br />
Griffith, W C ................................346, 1303*<br />
Grindstaff, R .......................................... 1819<br />
Griswold, J ............................................. 1309<br />
Grivas, P C ................................................. 72<br />
Groom, C J ............................................. 1639<br />
Groom, S ...............................181*, 479, 1460<br />
Groothuis, G M ..................................... 1913<br />
Gross, C L ...............................................777*<br />
Gross, E A .............................................1295*<br />
Gross, J A ..............................................1757*<br />
Gross-Steinmeyer, K ...........................1495*<br />
Groten, J ................................................. 1560<br />
Grubbs, R D ............................................789*<br />
Grundy, J G ...................................2211, 2224<br />
Grzemski, F ............................................530*<br />
Gu, J ...............................................723*, 1567<br />
Gu, X .......................................................721*<br />
Guadarrama, J C ..................................... 603<br />
Guallar, E ................................................. 430<br />
Guan, H ................... 1308, 1309, 1402, 1595<br />
Guan, X .................................................... 961<br />
Guarisco, J A .........................................1407*<br />
Gucer, P .................................................... 165<br />
Gudi, R ................................................... 2210<br />
Guengerich, F P ...................................1675*<br />
Guerriero, F J ..................................372*, 472<br />
Guest, R L ...................................2006, 2009*<br />
Guidotti, T L ............................................ 381<br />
Guigonis, J ............................................. 1732<br />
Guilarte, T R ...........52, 631, 673, 678*, 1542<br />
Guilfoil, A J ............................................ 2174<br />
Guillot, T ...............................................1097*<br />
Guillot, T S ..................................... 973, 1961<br />
Guindon, K A .......................................2265*<br />
Guiney, P .................................................. 370<br />
Guiney, P D ........................................... 1758<br />
Guizzetti, M ...........................................967*<br />
Gulumian, M ........................................1864*<br />
Gunasekar, P G ....................................... 622<br />
Gundersen, H .............................. 1056, 1057<br />
Gunnare, S ..............................................906*<br />
Guns, E ................................................... 1747<br />
Guo, C ................................................... 2117*<br />
Guo, L ....................................................1912*<br />
Guo, T L ......................878, 891, 1212, 1716*<br />
Guo, W ..................................................1264*<br />
Guo, Y .....................................................348*<br />
Guo, X .....................................................171*<br />
Guo-Ross, S ............................................972*<br />
Gupta, R ............................1759*, 1760, 1952<br />
Gupta, R C ........................... 215, 809*, 996*,<br />
...................................1000*, 1600, 1601, 1799<br />
Gupta, R K ............................................2153*<br />
Gustaffson, J .............................................. 57<br />
Gustafson, S C ......................................... 526<br />
Gustafsson, J ................................... 59, 1365<br />
Guth, D .................................................... 869<br />
Guthrie, K .............................................. 1720<br />
Gutierrez, M E .....................................1455*<br />
Gutierrez-Valdez, A ................................ 608<br />
Gutjahr-Gobell, R E .............................. 1745<br />
Gutting, B W ..........................................769*<br />
Guvenc, G .............................................. 1273<br />
Guzman, M ........................................... 1436<br />
Gwiazda, R .............................597, 598*, 630<br />
Gyamfi, M ................................... 1050, 1766<br />
H<br />
Ha, P ......................................................... 480<br />
Haasch, M L .......................735*, 1280, 2253<br />
Haataja, H .............................................. 1885<br />
Haber, L T .......................................373*, 379<br />
Habermann, G ............................. 168*, 1105<br />
Habib, N .................................................. 926<br />
Hack, C .................................................... 847<br />
Hadjout, N ....................................... 507, 894<br />
Hafner, J H ............................................. 1862<br />
Hageman, G ............................................ 426<br />
up-to-date information at www.toxicology.org 231<br />
Hagiwara, A .........................742*, 746, 1388<br />
Hahn, F F ........................................162*, 164<br />
Hahn, M E ....................................... 94, 1359<br />
Haighton, L A ........................................ 1408<br />
Hailey, J R .............................................. 1800<br />
Haines, W T ..................................966*, 2095<br />
Hakkinen, P J .......................................... 379<br />
Hakulinen, P ........................................... 749<br />
Hakura, A .............................................. 2213<br />
Hale, C S .................................................. 960<br />
Haley, J D ................................................. 338<br />
Haley, P J .................................................173*<br />
Haley, R .......................................1036, 1737*<br />
Halinen, A .............................................. 1881<br />
Halinen, A I ................................... 436, 1895<br />
Hall, A H .................................................. 487<br />
Hall, J O ................................................. 1407<br />
Hall, K W ..................................................72*<br />
Hall, M L ................................................ 1436<br />
Halladay, A K .........................................983*<br />
Hallberg, C .............................................. 727<br />
Halleema, F ............................................. 247<br />
Hallmark, N .......................................... 2258<br />
Halpen, A M ............................................ 178<br />
Halsey, T ................................................ 1222<br />
Halsey, T A ...........................................1218*<br />
Halstead, B .............................................. 519<br />
Halvey, P J ..............................................820*<br />
Hamada, Y ..............129, 531, 543*, 831, 837<br />
Hamade, a k ...........................................442*<br />
Hamadeh, H .......................................... 1784<br />
Hamadeh, H K ........................................ 121<br />
Hamid, R ............................................... 1631<br />
Hamill, C ..............................................1529*<br />
Hamilton, B F .......................................... 491<br />
Hamilton, J W ................................. 133, 154<br />
Hamilton, S B .............................. 2044, 2056<br />
Hamlin, R ...............................................340*<br />
Hamm, J ................................................. 1517<br />
Hamm, J T .......................... 923*, 1186, 2229<br />
Hammer, F ................................... 2101, 2104<br />
Hammock, B D ....................................... 106<br />
Hammond, B ........................................1404*<br />
Hammond, B G ........................ 1669*, 1671*<br />
Hammond, J A ........................................ 269<br />
Hammond, T ......................................... 1072<br />
Han, D ...................................................1432*<br />
Han, E .....................1421*, 1430, 1431, 2163<br />
Han, M ................................................... 1215<br />
Han, S .................................. 256, 1157*, 2290<br />
Han, T .......................563, 1098, 1099, 2222*<br />
Hancock, S ............................................... 161<br />
Hancock,, S .............................................. 600<br />
Hanig, J .......................................... 263, 2285<br />
Hanig, J P ..................................... 1513, 1842<br />
Hanley, T R .............................................. 585<br />
Hanlon, P ........................................828*, 829<br />
Hann, E .................................................1422*<br />
Hansen, D ................................................ 509<br />
Hansen, J M .......................... 820, 979, 1158*<br />
Hansen, S C ........................................... 1242<br />
Hansen, T N .......................................... 1854<br />
Hanson, J ............................................... 1916<br />
hanson, N ................................................ 540<br />
Hanson, R G .................................. 280, 1232<br />
Hanton, G ................................................ 830<br />
Happo, M S ............................................436*<br />
Haque, M ................................................932*<br />
Hara, H .................................................... 281<br />
Harada, K .................................. 175*, 2063*,<br />
.............................................2064*, 2067, 2068<br />
Harada, T ........................................831*, 837<br />
Harada, Y ............................................... 2037<br />
Harbell, J ...........................................10*, 484<br />
Harbell, J W ................................. 1630, 2001<br />
Harbison, R D ........................... 72, 419, 420<br />
Harbo, S J ............................... 506, 919, 1705<br />
Hardej, D ....................................... 609, 1827<br />
Harder, J ................................................. 1777<br />
Hardin, B D ........................................... 2096<br />
Hardy, C ................................................... 887<br />
Hardy, M .....................................1257*, 1597<br />
Hargreaves, A ...................................... 1511*<br />
Hargreaves, A J ..................................... 1950<br />
Harkema, J R .......................... 347, 438, 439,<br />
.............................449*, 876, 1363, 1771, 1772<br />
Harleman, J ............................................... 61<br />
Harling, R J ............................................ 2028<br />
Harmon, A W .................................. 135, 148<br />
Harmon, R ............................................. 2134<br />
Harney, A ............................................... 1759<br />
Harney, A S ............................................ 1772<br />
Harper, C E ...........................................1493*<br />
Harpur, E ............................................11, 669<br />
Harreman, M T ....................................... 656<br />
Harrill, J ................................................2162*<br />
Harriman, J F ........................................ 1397<br />
Harris, A J ................................................ 424<br />
Harris, C ............................. 979, 1140, 2256*<br />
Harris, C C ............................................ 1270<br />
Harris, D T ................................................20*<br />
Harris, E ................................................. 1089<br />
Harris, P S .............................................. 1598<br />
Harris, R ................................................ 2069<br />
Harris, W ............................................... 1950<br />
Harris, M A .............................................392*<br />
Harrison, J ............................................. 1070<br />
Harrison, L R ......................................... 1588<br />
Harrison, R ............................................ 1568<br />
Harrison, S ............................................... 362<br />
Harrod, K S ............................................. 460<br />
Hartgring, S ........................................... 1057<br />
Hartgring, S A ....................................... 1056<br />
Hartings, J M ......................................... 1470<br />
Hartman, H E .......................................1634*<br />
Hartmann, A ..........................................336*<br />
Hartmann, E .......................................... 1735<br />
Hartmann, L M ........................... 1818, 2225<br />
Hartnell, G ............................................. 1671<br />
Hartung, T ............................ 660*, 664, 665*<br />
Haruyama, M .......................................... 826<br />
Harvey, A ................................................1411<br />
Harvey, E ........................................518*, 539<br />
Harvey, R G ........................................... 1043<br />
Harvison, P J ............................. 70, 81, 2123<br />
Hasan, A .................................................. 713<br />
Haschek, W M ..........................1310*, 1312,<br />
.............................................. 1314, 1315, 1929<br />
Hasegawa, R ......................................... 1428<br />
Hasegawa, T ......................................... 1152*<br />
Haselden, J N .......................................... 491<br />
Haseman, J ............................................ 1628<br />
Haseman, J H .........................................662*<br />
Haseman, J K ........................................ 1506<br />
Hashemi, S B ......................................... 1551<br />
Hashim, G ............................................... 622<br />
Hashimoto, K .......................................... 837<br />
Haskins, J R ........................................... 1851<br />
Hassani, M ............................................1796*<br />
Hasse, R F .............................................. 1988<br />
Hassing, I ............................................... 1892<br />
Hassler, C ................................................342*<br />
Hasson, R ............................................... 2242<br />
Hassoun, E A ......................................... 2033<br />
Hastings, K L ........................................1347*<br />
Hasumura, M ........................................ 1503<br />
Hatcher, J M .........................................1961*<br />
Hattan, D G ..............................................39*<br />
Hattenbach, S A .................................... 1362<br />
Hattis, D ................................................1978*<br />
Hauschild, V ..........................................329*<br />
Haussmann, H ...................................... 1518<br />
Havel, P ................................................... 210<br />
Havics, A .....................................1475*, 1477<br />
Hawkridge, F M ..................................... 796<br />
Hawks, R ................................................808*<br />
Hayakawa, T ........................................... 151<br />
Hayashi, S ................................................ 175<br />
Hayashi, T ..................................... 270, 2205<br />
Hayden, P J ...................... 1171*, 1254, 2002,<br />
........................................................ 2003, 2191<br />
Haykal-Coates, N ......................... 448, 1213<br />
Hays, A ....................................................154*<br />
Hays, A M ........................................ 143, 157<br />
Hays, S ............................................258, 1149<br />
Hays, S M .......................................351*, 871<br />
Hazen, S ................................................1322*<br />
He, B ......................................................... 499<br />
He, J .......................................................... 709<br />
He, L ................................... 524, 1050, 1165*,<br />
...................................1290, 1766, 1918*, 1919<br />
He, Q .....................................76*, 1389, 1434<br />
He, W ....................................................... 686<br />
He, Y ......................................................... 121<br />
Healey, L B ..............................................888*<br />
Healy, L .................................................. 1784
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Hearne, G .............................................. 1864<br />
Hearnes, J .............................................. 1810<br />
Hebert, P .........................................898*, 899<br />
Heck, D .................................................. 1517<br />
Heck, D E ..................217, 1398, 1537*, 2171<br />
Heck, J D .................................................1186<br />
Hedge, J ................................................. 2039<br />
Hedge, J M ............................................. 2162<br />
Hedley, J ........................................1173, 1177<br />
Heffernan, J K ........................................800*<br />
Heflich, R H ............................................ 747<br />
Hege, A .....................................................60*<br />
Hege, A I .................................................. 774<br />
Heideman, W .................. 88, 91, 1824, 1825<br />
Heijne, W ............................................... 1560<br />
Hein, D W .......................... 1265, 1266, 1267<br />
Heinloth, A ............................................ 1855<br />
Heinloth, A N .........................................127*<br />
Heinz, J .................................................... 613<br />
Hejtmancik, M ....... 1181, 1425, 2035*, 2070<br />
Held, G ..................................................... 680<br />
Hellerstein, M ....................................... 1898<br />
Hemmer, M J ......................................... 1598<br />
Henderson, A .......................................... 356<br />
Henderson, I ............................................811<br />
Henderson, J D ..................................... 1278<br />
Henderson, R ............................................ 21<br />
Henderson, W M .................................2065*<br />
Hendrich, S .................................. 1316, 1385<br />
Hendricks, J D ......................................... 758<br />
Hendrickson, J ...................................... 1717<br />
Hendry, L B ........................................... 1040<br />
Henk, W ................................................. 1441<br />
Hennes, E C ............................................. 271<br />
Hennig, B ............................................... 1838<br />
Henry, E C ................................................84*<br />
Henry, M M ........................................... 1856<br />
Henry, S H ..............................................296*<br />
Henry, S P .................................................16*<br />
Henshel, D S .......................................... 2245<br />
Hensley, S C .................................1801, 2118<br />
Herbert, K ................................................ 540<br />
Herlich, J .......................................... 569, 755<br />
Herman, E H ......................................... 1842<br />
Hermann, E ........................................... 1912<br />
Hernandez, A ................................ 153, 1329<br />
Hernandez, D M ..........................891*, 1716<br />
Hernandez, L G .....................................730*<br />
Hernandez, M ......................................... 427<br />
Hernandez-Ochoa, I ............................ 1147*<br />
Herouet, C ............................................. 1307<br />
Herr, D W ...................................1091*, 1335<br />
Herreno-Saenz, D ................................. 2219<br />
Herring, S .............................................. 1042<br />
Herzyk, D J ...................... 166, 179, 873, 910<br />
Hescheler, J ............................................ 1996<br />
Hess, K ................................................... 1719<br />
Hess, K M .............................................. 1371<br />
Hess, R ................................................... 1373<br />
Hess, R A ................................................. 546<br />
Hessner, M ............................................. 2238<br />
Hester, S ......................................2149*, 2162<br />
Hester, S D ............... 1816, 2144, 2146, 2147<br />
Hesterberg, T .......................................... 418<br />
Hesterberg, T W ....................................400*<br />
Heussner, A ................................ 2113*, 2115<br />
Hew, K ....................................................914*<br />
Hew, K W .............................................2214*<br />
Heyer, N J .............................................. 1275<br />
Heyliger, S O ........................................1945*<br />
Hicks, S M ..............................................554*<br />
Hidestrand, M ............... 74, 274, 1036, 1737<br />
Hierlihy, A ......................................128, 568*<br />
Higa, T ....................................................... 94<br />
Higashimoto, M .................................... 1615<br />
Higgings, L ............................................ 1755<br />
Higgins, A .............................. 527, 537, 1557<br />
Hijioka, M ................................................ 833<br />
Hilakivi-Clarke, L A ..............................300*<br />
Hill, A J ......................................................91*<br />
Hill, B ..................................................... 1844<br />
Hill, C E ......................................1274*, 2236<br />
Hill, G D ................................................. 1800<br />
Hillegas, A ............................................... 873<br />
Hillegas, A E ...........................................179*<br />
Hillegass, J M .......................................2239*<br />
Himeno, S .............................................1612*<br />
Himmelstein, M W ........................ 230, 231,<br />
...................................................234*, 235, 236<br />
Hinckley, J ....................................... 161, 600<br />
Hinderliter, P M .....................................866*<br />
Hines, C ................................................1243*<br />
Hines, E P .............................................1369*<br />
Hines, M D ............................................ 1631<br />
Hines, R ................................................... 259<br />
Hines, R N ................................ 1974*, 1975*<br />
Hinson, J A .............................................. 224<br />
Hinton, D E ........................................... 1582<br />
Hintze, C J ............................................. 1593<br />
Hirabayashi, Y .....................................1380*<br />
Hiraga, T ................................................ 2037<br />
Hirano, S .........................................151, 1164<br />
Hirao, J ....................................................708*<br />
Hiratsuka, H ......................................... 1459<br />
Hirner, A V .................................. 1818, 2225<br />
Hiroki, I .................................................. 1501<br />
Hirose, A ........................................ 281, 2155<br />
Hirose, M ................. 1406, 1428, 1503, 1861<br />
Hirst, G C ................................................. 462<br />
Hirvonen, M ................................. 436, 1879,<br />
.............................................. 1880, 1881, 1895<br />
Hitchcock, J ........................................... 2205<br />
Hitchman, K ............................................ 921<br />
Hite, P ...................................................... 413<br />
Hitt, J E ....................................................1176<br />
Hlavacova, A ......................................... 2272<br />
Ho, E ......................................................... 930<br />
Ho, H .......................................................813*<br />
Hoadley, K ..............................................123*<br />
Hoagland, M ......................................... 1805<br />
Hoang, Y D ........................................... 1117*<br />
Hoberman, A ......................................... 1738<br />
Hoberman, A M .................. 804, 1075, 2193<br />
Hochberg, K ............................................ 695<br />
Hodel, A E ............................................... 656<br />
Hodge-Bell, K C .....................................506*<br />
Hodges, N ............................................. 2234<br />
Hodgson, E .............................. 358, 726, 781<br />
Hodson, P ................................................ 687<br />
Hoeger, S ...............................................2099*<br />
Hoel, D G ............................................... 1559<br />
Hoet, P ................................................... 1712<br />
H<strong>of</strong>fler, U ..............................................1794*<br />
H<strong>of</strong>fman, H B ........................................ 1767<br />
H<strong>of</strong>mann, M .......................................... 1625<br />
Holcombe, G ......................................... 1755<br />
Holcombe, G W .......................... 1754, 1756<br />
Holian, A ........................................ 908, 1890<br />
Holifield, N ........................................... 2159<br />
Holladay, S .............................................. 884<br />
Holladay, S D ...............................685*, 2261<br />
Holler, J .................................................. 1481<br />
Holley, G ................................................ 1623<br />
Hollingshead, B D .................................. 657<br />
Hollingsworth II, J W ............................ 928<br />
Holloway, G .......................................... 1634<br />
Holm, S E ............................................... 2084<br />
Holman, T ................................................ 630<br />
Holme, J A ............................................. 2287<br />
Holmes, A L ........................ 160, 1134, 1145*<br />
Holsapple, M ........................................ 1868<br />
Holsapple, M P .......................... 666*, 1695*<br />
Holson, J F ............................ 3*, 3*, 239, 240<br />
Holt, S ...........................................915*, 1464<br />
Homiski, M ........................................... 2233<br />
Honchel, R ............................................. 1513<br />
Honda, A ................................................1611<br />
Hong, S ..................................194, 382, 1155,<br />
.............................................1233*, 1234, 2257<br />
Hong, S K .............................................. 2121<br />
Hong, S M .............................................. 2183<br />
Honma, M ............................................2213*<br />
Honma, T ......................................542, 1080*<br />
Hood, D B .............................................. 1089<br />
Hood, R D .......................................... 3, 1067<br />
Hook, S .................................................. 1586<br />
Hooks, W ..............................................1639*<br />
Hooser, S B .............................................. 501<br />
Hooson, J ................................................. 480<br />
Hooth, M .......................... 1181, 2035, 2070*<br />
Hoover, D .............................................. 2134<br />
Hoover, S ..............................................1521*<br />
Hope, B ...................................................330*<br />
Hopke, P .................................................. 443<br />
Hopkins, N E .........................................356*<br />
232<br />
Hoppin, J A ............................................ 1333<br />
Horai, H ................................................... 496<br />
Horai, N ..................................................496*<br />
Horais, K .................................................1103<br />
Horand, F ................................................ 885<br />
Horie, K ................................................... 605<br />
Horiguchi, H ......................423, 1456, 1610*<br />
Horii, I ............ 129, 531, 543, 831, 837, 1899<br />
Horn, T L ..............................................1778*<br />
Horner, M ...............................................499*<br />
Hornung, M W ....................................2254*<br />
Horohov, D ............................................ 1012<br />
Horowitz, M ...........................................1107<br />
Horsmon, M ............................................ 793<br />
Horwitz, B P .......................................... 2127<br />
Hosdeshell, K ........................................ 1743<br />
Hossain, M M .............................1954, 1966*<br />
Houle, C D ............................................. 1781<br />
Houpt, J T .............................................2203*<br />
House, D .................................................. 863<br />
House, R .......................................467, 1348*<br />
House, R V ..................................... 810*, 811<br />
Hovland, D ............................................ 1373<br />
Howard, P C ..................................502, 652*,<br />
.............................................1565*, 2185, 2187<br />
Howard, W ............................................ 2097<br />
Howd, R A ............................................. 2105<br />
Howden, R ...................................... 828, 829<br />
Howell, K ............................................... 1591<br />
Hower, M ..................................................114<br />
Howlett, N ............................................. 2233<br />
Howroyd, P ......................................58, 581*<br />
Hoyer, P B ...............................................1120<br />
Hrubec, T C ............................................. 685<br />
Hrycay, E G ........................................... 1491<br />
Hseu, T ................................................... 2020<br />
Hsiao, S .........1310, 1312, 1314, 1315, 1929*<br />
Hu, C ...................................................... 2020<br />
Hu, C X .................................................... 536<br />
Hu, J J ......................................................301*<br />
Hu, S ......................................................1235*<br />
Hu, W ....................................126, 353*, 1700<br />
Hua, Y .................................................... 1528<br />
Huang, C ................................................. 305<br />
Huang, Y .................................................... 93<br />
Hubbard, A K ........................................ 1915<br />
Hubbard, J ............................................... 172<br />
Hubbs, A F ............................. 360, 701, 1443<br />
Hudgens, E E .......................................... 692<br />
Hudson, L G ...........................................1167<br />
Hudson, R T .........................................1598*<br />
Hueber, S M ..........................................1877*<br />
Huebner, H J ........... 1283, 1309, 1400, 1402<br />
Hueni, S E .............................................. 2127<br />
Huffman, L .............................................933*<br />
Huggett, T ............................................1626*<br />
Hughes, A ................................................ 732<br />
Hughes, B ...............................................413*<br />
Hughes, J ................................................. 503<br />
Hughes, M F ................................... 850, 864,<br />
.............................................1231*, 1250, 1568<br />
Huldermen, T ......................................... 705<br />
Hulet, S W ......................................775, 788*<br />
Hulette, B C ............................................1198<br />
Huljic, S ................................................. 2116*<br />
Humes, D G ................................ 1760, 1772<br />
Hummelke, G C ...................................1587*<br />
Humphrey, A ......................................... 1810<br />
Hung, C ................................................... 566<br />
Hunt, A .................................................. 1801<br />
Hunter, D L ................................... 966, 1335,<br />
.............................................1939*, 1940, 2095<br />
Hunter, P M ..........................................2080*<br />
Hunter, S ...............................................2248*<br />
Hunter, S S ............................................. 2255<br />
Hunter III, E S ......................................... 683<br />
Hurban, P .........................................119, 537<br />
Hurley, T D ............................................ 1723<br />
Hurst, H E ............................................... 516<br />
Hurtt, M E ......................................273, 1121<br />
Husain, K ................................................222*<br />
Hussain, S ...................................1625, 1719*<br />
Hussey, E ............................................... 1833<br />
Hutcheson, M S .................................... 2106<br />
Huttunen, K .....................1879, 1880, 1881*<br />
Hutz, R ................................................... 2238<br />
Hwang, E ..............................................2164*<br />
Hwang, J ........................................ 305, 2164<br />
Hwang, Y ......1421, 1431, 1524, 1525*, 1531<br />
Hyun, S .............. 717, 890, 1417, 1574, 1575<br />
I<br />
Ian, G .....................................................1465*<br />
Iatropoulos, M J ...........................741, 1500*<br />
Ichihara, G ............................................... 278<br />
Ichihara, T .............................................. 1388<br />
Ichimura, T .............................................. 197<br />
Ichisaki, S ................................................. 826<br />
Igarashi, K ............................................. 1380<br />
Ihnat, M A ...............................................1162<br />
Iida, M .................................................... 1727<br />
Iijima, T .................................................. 2063<br />
Ikeda, N ................................................. 1399<br />
Ikeda, T .................................................... 176<br />
Ikeda, Y .................................................... 423<br />
Illouz, K ................................93, 2044*, 2056<br />
Imai, N ..................................................... 746<br />
Imai, T ...................................................1503*<br />
Imaida, K ............................................... 1471<br />
Imaoka, M ..............................................812*<br />
Imazawa, T ............................................ 1406<br />
Inada, K ................................................... 945<br />
Inayat-Hussain, S H ................................47*<br />
Inayat-hussain, s h ..............................2276*<br />
Ingerman, L ................................. 1483, 2082<br />
Ingram, L ................................................. 133<br />
Inh<strong>of</strong>, C ................................. 662, 663, 1997,<br />
.............................................2005*, 2007, 2008<br />
Inman, A ................................................ 2180<br />
Inman, A O .................................2183, 2184*<br />
Inoue, A .................................................. 1432<br />
Inoue, K ....................................... 2064, 2068<br />
Inoue, T .......................................1380, 1633*<br />
Inoue, Y .......................................... 459, 1703<br />
Ionescu, M ..............................................174*<br />
Iordanova, V ..................................170, 807*<br />
Ip, C .....................................1170, 1907, 1908<br />
Ireson, R ................................................... 418<br />
Ironside, J ................................................. 464<br />
Irwin, R .................................................. 1376<br />
Isaacs, K R ................................................118<br />
Isbrucker, R ..........................................1429*<br />
Ise, R ....................................................... 1432<br />
Ishii, Y .......................................... 1406, 1861<br />
Ishino, F ................................................... 556<br />
Ishitobi, H ...............................................1611<br />
Islamzadeh, A ....................................... 1290<br />
Isobe, M ................................................. 1617<br />
Isola, D ....................................................1182<br />
Isola, D A ................................................1183<br />
Isom, G E ..................................... 1543, 2279<br />
Itagaki, H ......................................1192, 1193<br />
Itai, A ...................................................... 1703<br />
Ito, K ............................................... 708, 1433<br />
Ito, T ..............................................130*, 2043<br />
Ito, Y .................................... 1192, 1193, 1194<br />
Itoh, K .......................... 459, 816, 1833, 1861<br />
Itoh, N .................................................... 1617<br />
Itoh, T ......................................................604*<br />
Itzhak, Y ................................................. 1989<br />
Ivanov, V ................................................ 1494<br />
Iversen, P ............................................... 1246<br />
Ivnitski-Steele, I D .................................. 845<br />
Iwasaki, N ............................................. 1703<br />
Iwashita, K ............................................ 1928<br />
Iyer, P R ...................................................283*<br />
J<br />
Jaar, B G ..................................................1148<br />
Jabbour, J .................................................. 492<br />
Jackson, D .............................................1998*<br />
Jackson, D A .......................................... 2017<br />
Jackson, E R ............................................533*<br />
Jackson, G R ............................... 1171, 2003*<br />
Jackson, K .............................................. 1570<br />
Jacob, H .................................................. 1897<br />
Jacob, S ..........................................214, 1076*<br />
Jacobs, A .................................... 1026*, 1694*<br />
Jacobs, A C ....................................... 10, 1692<br />
Jacobs, J J ................................................ 2199<br />
Jacobs, J M ............................................... 137<br />
Jacobsen, M ............................................1511<br />
Jacobson-Kram, D ......... 7A, 7B, 672, 1027*<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Jacocks, H ...............................................1101<br />
Jaeckh, R ...................................... 2251, 2252<br />
Jaeschke, H ...................................... 63, 1053<br />
Jahng, Y .............................. 1574, 1575, 2263<br />
Jahun, J ....................................................475*<br />
Jain, A K ..................................................819*<br />
Jaiswal, A K ..................................... 818, 819<br />
Jakasa, I .........................................867, 1249*<br />
Jakel, R J ........................................220*, 1523<br />
Jakubowski, E ................................. 776, 785<br />
Jakubowski, E M ..........................773, 775*,<br />
.................................................... 786, 787, 794<br />
Jalava, P ........................................436, 1895*<br />
James, A ................................................... 863<br />
James, A R .............................................. 1463<br />
James, J T ................................................650*<br />
James, L P .................................................. 68<br />
James, M .......................................1113, 1596<br />
Jameson, R R ........................................1068*<br />
Janer, M .................................................. 1271<br />
Jang, G ...................................................... 467<br />
Januszkiewicz, A .................................... 767<br />
Jaques, P ................................................. 1453<br />
Jarabek, A ...............................................2110<br />
Jarabek, A M ...........1295, 1304, 1342*, 1467<br />
Jarema, K A .................................1437*, 1438<br />
Jarman, K H .......................................... 1705<br />
Jarnagin, K ............................................... 121<br />
Jarvis, J ............................................. 776, 787<br />
Jarvis, J R ................................................. 788<br />
Jaskot, R H ............................................... 441<br />
Jaspers, I ...................... 447, 930*, 942, 1018*<br />
Jasti, S L .................................................... 284<br />
Jayara, K .................................................. 500<br />
Jayaram, B ............................................. 2069<br />
Jayyosi, Z ........................................114, 2131<br />
Jean, P A ............................1507, 1510, 1812*<br />
Jefcoate, C .............................................. 2047<br />
Jefcoate, C R ...........................................1164<br />
Jeffcoat, A ................................................. 732<br />
Jefferies, D ..................................1201, 1293*<br />
Jefferson, W ..................................260, 1370*<br />
Jeffery, E H ................................................. 65<br />
Jeffrey, A M ...................................741*, 1500<br />
Jeffries, H ......................................... 930, 942<br />
Jeng, C .....................................................1190<br />
Jeng, W ................................................... 1077<br />
Jenkins, C M ............................................ 696<br />
Jenkins, S ................................................. 512<br />
Jennings, L ............................................... 997<br />
Jennings-Gee, J ...................................... 1792<br />
Jensen, K M ........................................... 1746<br />
Jensen, N S ............................................. 2014<br />
Jeon, T ...............717*, 890, 1417, 1574, 1575<br />
Jeon, Y J .................................................1413*<br />
Jeong, H ...................890, 1409, 1415*, 1416,<br />
......................... 1421, 1422, 1423, 1426, 1427,<br />
......................... 1430, 1431, 1524, 1525, 1531,<br />
.................................... 2163, 2165, 2168, 2169<br />
Jeong, T ................................. 717, 890, 1417,<br />
.........................1421, 1431*, 1574, 1575, 2263<br />
Jeong, S ................................................... 111*<br />
Jerat, S ...................................................... 480<br />
Jernigan, J J ............................................ 1067<br />
Jia, L .......................................................... 466<br />
JIA, N ....................................................... 542<br />
Jia, Z ........................................................2119<br />
Jiang, H .................................................1815*<br />
Jiang, J ...............................2284, 2294, 2295*<br />
Jiang, L ....................................................1311<br />
Jiang, S ..........................................748, 1613*<br />
Jiang, W ................................. 714, 756, 1845<br />
Jikuzono, T .............................................. 833<br />
Jillian, D H ............................................. 1783<br />
Jimenez, I ................................................. 603<br />
Jimenez, L .............................................. 1907<br />
Jimenez Velez, B D ............................... 1893<br />
Jimenez-Velez, B D ................................. 445<br />
Jin, C ..................717, 890*, 1417, 1574, 1575<br />
Jin, G ................................................. 196, 894<br />
Jin, L ........................................................1165<br />
Jin, X ......................................................... 305<br />
Jindo, T ..................................................... 267<br />
Jirtle, R L .................................................. 572<br />
Joad, J P ........................................ 1014, 1645<br />
Johansen, M E ..............................937, 1219*<br />
Johanson, G ...........................352*, 853, 868,<br />
................................................ 906, 1248, 2198<br />
Johansson, N ........................................2062*<br />
Johnson, D A ......................... 220, 814, 1852<br />
Johnson, D J ........................................... 1945<br />
Johnson, E .............................................. 2240<br />
Johnson, E W ................545, 783, 792*, 1883<br />
Johnson, F ................................................ 970<br />
Johnson, F O ...........................................969*<br />
Johnson, J ................................................719*<br />
Johnson, J A ...................220, 814*, 984, 985,<br />
.......................... 1079, 1522, 1523, 1721, 1852<br />
Johnson, J D .............. 194, 1181*, 1233, 1234<br />
Johnson, J E ..........................................1061*<br />
Johnson, J M ...........................................287*<br />
Johnson, K ............................................... 844<br />
Johnson, M D .........................569, 755, 1174<br />
Johnson, R ............................................... 408<br />
Johnson, R D ......................................... 2254<br />
Johnson, S .............................................. 1089<br />
Johnson, V ............................................... 701<br />
Johnson, W D .............................1777*, 1778<br />
Johnson, W H .......................................... 159<br />
Jokinen, M P .......................................... 1506<br />
Jollow, D J ................................................ 207<br />
Jolly, P E ................................................. 1283<br />
Jones, A .................................................... 345<br />
Jones, A D .................................................. 89<br />
Jones, B C ............................................... 1631<br />
Jones, C .................................................. 2147<br />
Jones, D P ........................................820, 1158<br />
Jones, H .......................................... 824, 1843<br />
Jones, L ..................................................... 540<br />
Jones, P D ............................................... 2150<br />
Jones, R ...........................................247, 493*<br />
Jones, R D .................................... 1637, 1642<br />
Jones, T ..................................................... 784<br />
Jonker, D ................................................ 1560<br />
Jordan, H L .............................................. 491<br />
Jordan, V ................................................ 1807<br />
Jortner, B .................................................. 600<br />
Jortner, B S ................161, 1090*, 1943, 1944<br />
Jose, J .......................................................... 44<br />
Joseph, P ..................................... 1163*, 1166<br />
Joung, K E ........................................ 202, 720<br />
Jovanovic, M L ...................848, 1508*, 1509<br />
Joyner, D R ............................................ 1295<br />
Juberg, D R ...........................................1338*<br />
Jun, I ..................717, 890, 1417*, 1574, 1575<br />
Jung, C T ................................................ 2177<br />
Jung, K ........ 1415, 1416*, 1426*, 1524, 2168<br />
Junker, U ................................................ 2010<br />
Juretschke, H ....................................114, 510<br />
K<br />
Kabar<strong>of</strong>f, L C ..........................................883*<br />
Kabiri, M ...............................................2302*<br />
Kabirov, K ...............................................489*<br />
Kadambi, V J ......................................... 2027<br />
Kadiiska, M ..................................759, 1321*<br />
Kadry, A M .............................................242*<br />
Kaefferlein, H U .................................... 1282<br />
Kaetzel, R S .............................................. 693<br />
Kaewamatawong, T ............................... 700<br />
Kagan, V E ................ 701, 2188, 2282, 2283,<br />
.......................... 2284, 2294, 2295, 2296, 2297<br />
Kahl, M D .............................................. 1746<br />
Kai, M ....................................................... 556<br />
Kaiser, E ..................................................230*<br />
Kaiser, S J ................................................. 682<br />
Kala, S .................................................... 1060<br />
Kala, S V .................................................1137<br />
Kale, V M ..............................................2167*<br />
Kalisak, D L ........................................... 1304<br />
Kalra, R ...................................................... 21<br />
Kamal, M ............................................... 2108<br />
KAMATA, E ............................................ 281<br />
Kamboj, S ................................................. 332<br />
Kamei, N ................................................ 2068<br />
Kamel, F ......................................1332, 1333*<br />
Kamendulis, L M .........751, 752*, 760, 1787<br />
Kamenosono, T ....................................... 806<br />
Kamikawa, Y ........................................... 709<br />
Kaminski, N .........................................1868*<br />
Kaminski, N E ....................... 369, 876, 1874<br />
Kampf, J W .................................. 1936, 1937<br />
Kamuren, Z T ........................................ 1401<br />
Kan, L ....................................................... 585<br />
up-to-date information at www.toxicology.org 233<br />
Kan, Z ....................................................... 287<br />
Kanade, P ..............................................2289*<br />
Kanefuji, K ............................................. 1707<br />
Kang, H .....................................................111<br />
Kang, I .................................................... 2290<br />
Kang, J ...................................................1215*<br />
Kang, T ................................................... 2290<br />
Kang, Y ......................................... 1836, 1839<br />
Kang, Y J ............................................... 6*, 6*<br />
Kanhai, H ................................................ 606<br />
Kanki, K ......................................1406, 1861*<br />
Kannan, S ................................................818*<br />
Kannan, S - .............................................221*<br />
Kanno, J ................................................. 1380<br />
Kanthasamy, A ............................... 633, 633,<br />
.............................................. 1526, 1527, 1527<br />
Kanthasamy, A G ......................1526, 1656*,<br />
........................................... 1985*, 1986*, 1988<br />
Kanz, M F .....................................498, 1922*<br />
Kao, L M .................................................1174<br />
Kapeghian, J .........................................1993*<br />
Kapetanovic, I ....................................... 1785<br />
Kaphalia, B S ......... 82, 912, 913, 1558, 1629<br />
Kaphalia, L .....................................469*, 498<br />
Kaplan, B L .............................................369*<br />
Kaplan, D J ............................................ 1905<br />
Kapralov, A A .............................. 2283, 2284<br />
Karakaya, A ..........................................1268*<br />
Karanth, S ........................................ 51, 1951<br />
Karasov, W H ........................................ 1757<br />
Kardas, M .................................................. 67<br />
Kari, F W ................................................ 1044<br />
Kariya, c t ..............................................1853*<br />
Karlsson, J ................................................ 162<br />
Karoly, E D .............................................683*<br />
Karrow, N ................................................ 883<br />
Kasahara, T ...............................................117<br />
Kasamatsu, T ........................................1399*<br />
Kashida, Y ......................................211, 1793<br />
Kaspareit, J ...........................168, 1105, 1636<br />
Kasprzak, K ................................... 694, 1013<br />
Kasten-Jolly, J ...............................895, 1064*<br />
Katein, A ........................................ 824, 1779<br />
Katoh, M ................................................ 1251<br />
Katsutani, N .........................................1931*<br />
Kaufmann, W .............................. 1056, 1057<br />
Kaufmann, W K .......................................119<br />
Kavanagh, T .................................... 225, 813<br />
Kavanagh, T J ...................... 579, 1271, 1859<br />
Kawabata, T ............................................ 171<br />
Kawabata, T T ......................................... 898<br />
Kawabe, M ............................................ 1388<br />
Kawahara, J ............................................. 175<br />
Kawai, K ................................................ 2188<br />
Kawamura, N ......................................... 700<br />
Kawamura, S ......................................... 1730<br />
Kawano, Y ..............................................763*<br />
Kawasuso, T .......................................... 1459<br />
Kayama, F ...........................423*, 1456, 1610<br />
Kaysser-Kranich, T ................................. 121<br />
Kayton, R J ............................................. 1549<br />
Kazim, S ................................................... 222<br />
Ke, S .................................................. 107, 721<br />
Ke, q ......................................................1789*<br />
Keane, M J ............................................2223*<br />
Kearns, S ................................................ 1210<br />
Keay, J ..................................................... 2261<br />
Keebaugh, M ........................................... 795<br />
Keegan, S P .............................................910*<br />
Keeler, G J ........................................ 438, 439<br />
Keen, C L ............................................... 1087<br />
Keenan, J J ..............................................415*<br />
Keep, R F ............................................... 1528<br />
Kegelman, T A ........................................ 951<br />
Keil, D E ..................................................882*<br />
Keita, K .................................................. 1428<br />
Keith, S ................................................... 1483<br />
Keller, L H ................................................ 275<br />
Kelley, M F ..............................................1174<br />
Kelley, R W ...................................... 725, 740<br />
Kelly, C M .............................................2031*<br />
Kelly, D P ................................................. 945<br />
Kelly, J ................................................... 1177*<br />
Kelly, J B ..................................................796*<br />
Kelly, J T ................................................... 699<br />
Kelly, T ......................................... 1626, 1779<br />
Kelman, B J ...........................................2096*<br />
Kelman, D R ...........................................555*<br />
Kelsey, K T ..............................................1148<br />
Kemmerer, M .................................. 569, 755<br />
Kemp, C ................................................. 1804<br />
Kemper, R A .........................231, 234, 1578*<br />
Kemppainen, B W ................................ 1384<br />
Kende, A S ................................................. 84<br />
Kenne, K .................................................. 508<br />
Kennedy, G .............................................1127<br />
Kennel, P ...................................... 1731, 1732<br />
Kennett, M J ...........................................1911<br />
Kensler, T ................................................... 93<br />
Kensler, T W ........................................ 58, 59<br />
Kenyon, E M ........................856, 864*, 1231<br />
Keravec, V ............................................... 446<br />
Kerfoot, E J .............................................. 284<br />
Kerger, B D .....................................257*, 412<br />
Kerkvliet, N I ........................................ 1873<br />
Kermp, C J ............................................. 1803<br />
Kern, C ............................................597*, 598<br />
Kern, J C ......................................1522*, 1852<br />
Kern, J T ........................................220, 1721*<br />
Kern, P ....................................................1196<br />
Kernag, C ............................................... 2275<br />
Kerr, H M ............................................... 1754<br />
Kerzee, J ................................................1203*<br />
Kerzee, J K ................................... 2189, 2228<br />
Keshava, N .............................................401*<br />
Kessler, K ............................................... 2076<br />
Kester, J E ................................................350*<br />
Kettrup, A .............................................. 2050<br />
Keys, D ................................................... 2039<br />
Keys, D A ........................................402*, 847<br />
Kezic, S ......................................... 1249, 2199<br />
kezic, s .....................................................867*<br />
Khachik, F ...............................................1189<br />
Khalil, S .................................................. 1551<br />
Khan, M ................................................... 221<br />
Khan, M F ........................................ 912, 913<br />
Khan, S H ..................................................82*<br />
Khan, S I ................................................ 1588<br />
Khan, W A ......................................961*, 962<br />
Khan-Malek, R ................................ 560, 577<br />
Kiebler, Z ....................................... 209, 1718<br />
Kikkawa, R ...........................129, 531*, 1899<br />
Kikuchi, Y ................................................ 175<br />
Kikushima, Y ......................................... 1703<br />
Kim, B .............................................. 41, 1868<br />
Kim, D ..................................720, 728*, 1427,<br />
.............................................1531, 1574, 2169*<br />
Kim, D J ..................................586*, 587, 588<br />
Kim, E .......................................... 2257, 2263<br />
Kim, G .....717, 890, 1417, 1574, 1575*, 1635<br />
Kim, H .................................552*, 552*, 907*,<br />
................................... 1043, 1215, 1217, 1247,<br />
....................... 1421, 1431, 1905*, 2168*, 2169<br />
Kim, H J ................................................1245*<br />
Kim, J ............................41, 985*, 1415, 1416,<br />
..................................1421, 1422, 1430*, 1431,<br />
........................................... 2163*, 2169, 2263*<br />
Kim, J S .................................................... 202<br />
Kim, K ................................ 46*, 1245, 1247*,<br />
.............................................. 1454, 1764, 1807<br />
Kim, K H ...................................... 1803, 1804<br />
Kim, P M ................................................ 2259<br />
Kim, S ........................... 156, 188*, 379*, 428,<br />
........................... 719, 1179, 1301*, 1454, 1635<br />
Kim, S K ................................................. 1925<br />
Kim, S S ...................................................1179<br />
Kim, T ...................................................2290*<br />
Kim, W ................................................... 1261<br />
Kim, Y ............................................ 256, 2164<br />
Kim, Y C ................................................1925*<br />
Kim, Y W ................................................. 720<br />
Kimbell, J ..............................................1304*<br />
Kimbell, J S ............................ 347, 699, 1295<br />
Kimber, I .................. 5*, 37, 124, 1196, 1198,<br />
......................... 1200, 1201, 1204, 1206, 1207,<br />
.......1209, 1375, 1710, 1711, 1736, 1739, 1999<br />
Kimbrough, C ........................................... 59<br />
Kimmel, C A .................................. 378, 1225<br />
Kimura, K ................................................ 886<br />
Kimura, M ............................................. 2064<br />
Kimura, T .............................................1617*<br />
Kind, C ..................................................... 508<br />
King Heiden, T ....................................2238*<br />
Kini, V .......................................... 2284, 2295<br />
Kini, V A ...............................................2296*<br />
Kiningham, K ............................................ 66
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Kinsey, G R ...........................................2125*<br />
Kinter, L B .......................................339*, 343<br />
Kinzell, J ................................... 233, 239, 240<br />
Kinzell, J H ............................. 230, 231, 232,<br />
............................ 234, 235, 236, 237, 238, 347<br />
Kiplinger, G R ...................................... 1137*<br />
Kirby, P ................................................... 2215<br />
Kirk, C A ...............................................2207*<br />
Kirkpatrick, A ....................................... 1598<br />
Kirkpatrick, J B ..................................... 1394<br />
Kirlin, W G ............................................ 1570<br />
Kirpnick, Z .......................2230, 2232*, 2233<br />
Kirsch, G .................................................836*<br />
Kirschten, N P ......................................... 795<br />
Kiser, G L ................................................. 121<br />
Kiser, R C ....................774, 780, 2201, 2202*<br />
Kishnani, N ............................................. 798<br />
Kisin, E ..................................701*, 705, 2188<br />
Kisin, E R ............................................... 2282<br />
Kisin, K .................................................... 702<br />
Kitada, K ................................................ 1380<br />
Kitamura, Y ....................... 1406, 1428, 1861<br />
Kitchin, K T ............................................142*<br />
Kito, G ............................ 826, 833, 834, 1094<br />
Kitoh, J ..................................................... 278<br />
Kittelson, D ............................................. 443<br />
Kiyama, R .............................................. 1432<br />
Kiyosawa, N .................................. 708, 1433<br />
Klaassen, C D ................... 67, 564, 570, 815,<br />
....................................821, 1220, 1229, 1328*,<br />
.........................1687*, 1761, 1762, 1763, 2140<br />
Klapper, D G ........................................... 500<br />
Klaunig, J E .....................670*, 751, 752, 760<br />
Klausner, M .................................1171, 1254,<br />
........................................... 2002*, 2003, 2191*<br />
Kleeberger, S ........................................... 828<br />
Kleeberger, S R ...................................... 1857<br />
Klei, L R ...................................... 1133, 1162*<br />
Klein, B ................................................... 1943<br />
Klein Koerkamp, E ................................. 177<br />
Klein Koerkamp, E I .............................. 953<br />
Kleiner, H E ..........................................1419*<br />
Kleinman, M ......................................... 1448<br />
Kleinman, M T .............................. 442, 1066<br />
Kleinow, K M .............................. 1587, 1596<br />
Kleter, G A ............................................. 1672<br />
Kleymenova, E .....................................1372*<br />
Kligerman, A D ......................................152*<br />
Kline, T M ................................................ 656<br />
Klinefelter, G R ....................................... 547<br />
Klintworth, H M ..................................1959*<br />
Klug, S .......................................... 2251, 2252<br />
Klumb, C A ............................................ 1572<br />
Kluz, T .................................................... 1789<br />
Knaak, J B ............................ 870, 1298, 2157<br />
Knadle, S .................................................254*<br />
Knall, C .................................................... 456<br />
Knapton, A .................................... 263, 1842<br />
Knapton, A D ........................................ 1513<br />
Knecht, D ................................................. 507<br />
Knemeyer, I ............................................. 860<br />
Knight, A ................................................ 1037<br />
Knight, T .................................................... 63<br />
Knight, T R ............................................ 2140<br />
Knippels, L ............................................ 1205<br />
Knochel, J ................................................. 949<br />
Knoebl, I ................................................ 1583<br />
Knox, P ................................................... 1048<br />
Knudsen, T B ..............................1979, 1984*<br />
Kobayashi, H .............................1954*, 1966<br />
Kobayashi, K .........................459*, 886, 980,<br />
.............................................. 1080, 1380, 1633<br />
Kobayashi, T ..........................130, 451*, 452<br />
Kobayashi, Y ..........................................151*<br />
kobayashi, k ...........................................981*<br />
Kocbach, A ..............................................417*<br />
Kocerha, J ................................................575*<br />
Koch, W H ..............................................950*<br />
Kock, N D .............................................. 1792<br />
Kocsis, M G ..........................................1920*<br />
Kodama, Y ................................... 1380, 1861<br />
Kodavanti, P R ...........................1081*, 1964<br />
Kodavanti, P S ...................................... 1082<br />
Kodavanti, U P ..............433, 441*, 504, 927<br />
Koenig, J ................................................ 1453<br />
Koga, T ..........................................833, 1707*<br />
Koganti, A .............................................. 2056<br />
Koike, E ...........................................451, 452*<br />
Koizumi, A .............. 2063, 2064, 2067, 2068<br />
Kok, E J .................................................. 1672<br />
Kolaja, K ...... 126, 353, 521, 522, 1700, 1830<br />
Kolaja, K L ............................ 514, 642*, 646*<br />
Koller, L D ................................... 1478, 1479<br />
Kolman, K ............................................. 1602<br />
Komarov, A .............................................1136<br />
Komiskey, H ...........................................596*<br />
Komiyama, M ......................................... 543<br />
Kommineni, C ....................................... 2188<br />
Komulainen, H ....................................... 749<br />
Kondraganti, S ...............................714, 756*<br />
Kong, L ................................................... 1845<br />
Konno, N ................................................. 607<br />
Konsoula, R ................................1621, 1627*<br />
Kooter, I M ..............................................929*<br />
Kopchick, J J ............................................ 582<br />
Kopf, P G ................................................846*<br />
Koplovitz, I .................................. 2201, 2202<br />
Koppelman, S ........................................ 1205<br />
Kopplin, M .............................................. 153<br />
Kopplin, M J ............................................ 146<br />
Koprowski, S L ..................................... 2246<br />
Korb, S .................................................... 1897<br />
Kordaz, K ................................................. 252<br />
Korkalainen, M ..................................... 2042<br />
Kornman, K ..............................................38*<br />
Korrapati, M C .......................75, 731, 2137*<br />
Korte, J ................................................... 1755<br />
Korte, J J ................................................1754*<br />
Korte, S ..................................................... 478<br />
Kosian, P ................................................ 1755<br />
Kosian, P A .................................. 1754, 1756<br />
Kostich, M ............................................. 1709<br />
Kostrubsky, S .......................................1049*<br />
Kostrubsky, V ...............................490*, 1916<br />
Kostyniak, P J ........................................ 2157<br />
Kotha, L ................................................1808*<br />
Kouadio, J H .......................................... 1440<br />
Kovalenko, A L ....................................... 468<br />
Kovelesky, R ............................................ 461<br />
Koza-Taylor, P H .................................1802*<br />
Kracko, D ................................................199*<br />
Kraeling, M E .......................................2177*<br />
Kraft, A D ....................................1079*, 1522<br />
Kramer, J .........................................790, 832*<br />
Kramer, K ................................................ 519<br />
Kramer, P M .......................................... 1788<br />
Kransler, K M .............................. 2038, 2157<br />
Krantz, Q T ................................................ 49<br />
Krantz, T ................................................ 1214<br />
Krause, R J ............................................. 1572<br />
Krauthauser, C ................................ 776, 787<br />
Krauthauser, C L ..................................... 788<br />
Kreider, M L .........................................1069*<br />
Kremer, J J ...............................................862*<br />
Kretz, S ................................................... 2010<br />
Kreyling, W ............................................. 204<br />
Krieger, R ................................................. 415<br />
Krieger, R I ...................................414*, 1279<br />
Krieger, S M ........................................... 2224<br />
Kris-Etherton, P ........................................ 40<br />
Krishna, C ...................................... 484, 1628<br />
Krishnamoorthy, R ................................. 465<br />
Krishnan, K ....................259, 349, 851, 868*<br />
Krishnaraj, R ........................................1785*<br />
Kristian, T .............................................. 1960<br />
Kroetlinger, F ........................................ 1735<br />
Krolski, M .............................................. 1297<br />
Kromhout, H ......................................... 1334<br />
Kronenberg, J ........................................ 1404<br />
Kronenwetter-Koepel, T A .................... 682<br />
Kropsh<strong>of</strong>er, H ....................................... 1878<br />
Krsmanovic, L ....................................... 2210<br />
Krueger, S K .......................................... 1499<br />
Kruhlak, N ............................................. 2204<br />
Krull, D .................................................... 905<br />
Kruse, J ........................................... 867, 1249<br />
Ku, W W ................................................ 2230<br />
Kubaszky, R E ........................................203*<br />
Kubilus, J ..................1171, 2002, 2003, 2191<br />
Kubota, K ................................................. 709<br />
Kubota, R ............................................... 2155<br />
Kudo, Y ...................................459, 607, 944*<br />
Kueberuwa, S ........................................ 2100<br />
Kuffner, E K ........................................... 1048<br />
Kuijpers, M .................................. 1056, 1057<br />
Kuiper, H A ..........................................1672*<br />
234<br />
Kulas, J ................................................... 1387<br />
Kulkarni, G .....................................925*, 938<br />
Kulkarni, S ..................................... 490, 1049<br />
Kullman, S W ........................................ 1582<br />
Kumagai, Y .............................................. 183<br />
Kumiski, D ............................................ 1553<br />
Kunne, C ................................................ 1051<br />
Kunugita, N .........................................2206*<br />
Kunz, S ..................................................2054*<br />
Kuper, F ................................................. 1208<br />
Kuper, F C ................................................ 953<br />
Kupperblatt, G G ................................. 1176*<br />
Kurail, E ................................................... 166<br />
Kurata, Y ...............................................1251*<br />
Kurian, B .................................................. 214<br />
Kuriki, H ................................................ 1703<br />
Kurnikov, I V ......................................... 2284<br />
Kurochkin, I N ........................................ 192<br />
Kuroiwa, Y ............................................ 1406<br />
Kurosky, A ............................................... 214<br />
Kurz, M .............................................114, 510<br />
Kushida, M .............................. 750, 980, 981<br />
Kushleika, J V ............................... 184, 1216<br />
Kuwabara, H ........................................... 678<br />
Kuwagata, M ..........................954, 988, 989*<br />
Kuwano, K .............................................833*<br />
Kuzutani, K ................................... 799, 1640<br />
Kwack, S ................................................ 1635<br />
Kwak, M .............................................. 58, 59<br />
Kwekel, J ................................................ 1759<br />
Kwekel, J C .................................1771*, 1772<br />
Kwok, A ................................................. 1784<br />
L<br />
L’Esperance, G .............................1127, 1128<br />
La Du, J .................................................. 2243<br />
La Merrill, M ................................712*, 1840<br />
Labarre, G .............................................. 2156<br />
Labenski, M T ............................1801*, 2275<br />
Labhart, P ................................................ 109<br />
LaCasse, E R ...........................................805*<br />
Ladenheim, B ........................................ 1544<br />
Ladics, G ................................................ 1307<br />
Ladics, G S ..............................................314*<br />
LaDow, K ............................103, 1512*, 2267<br />
LaGattuta, M S .......................................1195<br />
Lai, K P ....................................................553*<br />
Lai, Z ........................................................ 881<br />
Lainee, P .................................................. 838<br />
Lake, B G ......................................669, 2160*<br />
Lakin, M ................................................... 418<br />
Laliberte, J ....................................... 203, 480<br />
Lalko, J ..................................................1202*<br />
Lalla, J ...................................................... 222<br />
Lallli, J ...................................................... 486<br />
Lam, C ...................................................... 650<br />
Lam, M ................................................... 2120<br />
Lam, T ...................................................... 442<br />
Lamango, N S ......................................2158*<br />
Lamar, P C ......................... 1602, 1605, 2129<br />
Lamartiniere, C A ............ 1108*, 1492, 1493<br />
Lamb, I ................................................... 1405<br />
Lamb, J C ................................................319*<br />
Lambert, C ............................................1865*<br />
Lambert, G R ......................................... 2268<br />
Lambright, C ..................... 1374, 1743, 1744<br />
Lammers, J ........................ 1056, 1057, 2087<br />
Lampertsdoerfer, T ................................2114<br />
Lan, L ......................................................... 65<br />
Lan, Q ..................................................... 1301<br />
Landauer, M R .......................................790*<br />
Landgren, C A ......................................1316*<br />
Landry, M ................................................ 480<br />
Landry, S D ............................................ 1597<br />
Landry, T D ..........................................1696*<br />
Landvik, N ............................................ 2287<br />
Lane, R R ............................................... 1935<br />
Langley, R .................................................. 21<br />
Lans, I ..................................................... 1708<br />
Lantum, H M .......................475, 1411, 1439<br />
Lantz, C ...................................143*, 154, 157<br />
Lantz, R .................................................... 936<br />
Lantz, R C .......................................159, 2119<br />
Lanza, D L ............................................. 1219<br />
Lapczynski, A ...................................... 1182*<br />
Lapin, C ................................................... 418<br />
Lapin, C A ................................................ 400<br />
Lapointe, G .............................................. 244<br />
Lapointe, J ............................................... 173<br />
LaPointe, J M ........................................... 898<br />
Lappalainen, M ..................................... 1880<br />
LaPres, J ..................................................1130<br />
LaPrete, V .............................................. 2000<br />
Lariviere, J ............................................... 133<br />
Larkin, P ................................................ 2023<br />
Larsen, R D .............................................710*<br />
Larson, T ................................................ 1453<br />
Larsson, S ................................................ 679<br />
Lash, L H ....................................1822*, 2127<br />
Laskin, D ................................................ 1933<br />
Laskin, D L .................................... 931, 1054<br />
Laskin, J ................................................. 1933<br />
Laskin, J D ......... 217, 931, 1054, 1398, 2171<br />
Lasky, R E .............................................. 1085<br />
Lasley, S M .................................. 628*, 1351*<br />
Latchoumycandane, C ........................1527*<br />
Latendresse, J .................................. 59, 2137<br />
Latendresse, J R ........................... 62, 73, 77,<br />
.............................................. 1910, 2139, 2141<br />
Lattier, D ................................................ 1583<br />
Lau, B ..................................................... 1383<br />
Lau, C ..............280, 1232*, 1906, 2066, 2255<br />
Lau, D ..................................................... 1095<br />
Lau, S S ........................147, 823, 1801, 2118,<br />
...............................................2119, 2275, 2281<br />
Lauer, F T ......................................... 302, 892<br />
Laughter, A ...............................................57*<br />
Lavin, A .................................................11, 28<br />
Lavin, A L .................................................. 24<br />
LaVire, H ..............................................1584*<br />
Lawal, T ................................................. 2214<br />
Lawrence, B ....................544*, 807, 874, 875<br />
Lawrence, D ............................................ 196<br />
Lawrence, D A ...................... 189, 895, 1064<br />
Lawrence, T N .......................................273*<br />
Lawrence, W B ...................................... 1394<br />
Laws, S C ........................... 1728, 1733, 1745<br />
Lawton, M ............................... 535, 540, 559<br />
Lawton, M P .................................643*, 1802<br />
Lazis, S ................................................... 1865<br />
Lazorchak, J M ...................................... 1582<br />
Le Bigot, J ...............................................838*<br />
Lea, L J ...................................................1392*<br />
Leach, C ................................................1346*<br />
Leach, G J ............................................... 2203<br />
Leakeas, C L ............................................ 526<br />
Leakey, J ................................................... 706<br />
Leakey, J E ..................................... 355, 1813<br />
Leakey, T I ............................................... 355<br />
Leal, F A ................................................ 1168*<br />
Learn, D B ...................................1075, 2193*<br />
Leatherberry, G ....................................... 169<br />
Leavens, T ..............................................863*<br />
Leavitt, S ...................................... 2144, 2146<br />
Lebetkin, E H .......................................1230*<br />
Leblond, N ...................................... 840, 841<br />
Leb<strong>of</strong>sky, M ........................................... 2034<br />
Ledbetter, A D ................. 433, 441, 448, 927<br />
Lee, B .......................................................1148<br />
Lee, C ........................................... 1215, 2164<br />
Lee, D ........... 60, 717, 890, 1417, 1574, 1575<br />
Lee, D W .................................................223*<br />
Lee, E ........................... 552, 890, 1421, 1431,<br />
.............................................. 1574, 1575, 2263<br />
Lee, F W ................................................1813*<br />
Lee, F Y .................................................... 288<br />
Lee, G ..................................................... 1373<br />
Lee, J .............................41, 907, 1079, 1217*,<br />
...................................1219, 1417, 1764*, 2164<br />
Lee, K ...................................... 108, 122, 186,<br />
.................918, 1217, 1409, 1524*, 2168, 2169<br />
Lee, K M ......................506, 919*, 1507, 1705<br />
Lee, K P .................................................... 945<br />
Lee, L ........................................... 1180*, 1790<br />
Lee, M .................................................... 1046<br />
Lee, M G .................................................916*<br />
Lee, P C ...................................................266*<br />
Lee, R .............................. 743, 744, 926, 1635<br />
Lee, R B .................................................... 164<br />
Lee, R V .................................................... 428<br />
Lee, S ............................717, 729*, 890, 1006,<br />
..................................1261, 1417, 1574*, 1575,<br />
.............................................. 1635, 2164, 2266<br />
Lee, T ........................................................ 410<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Lee, W ...........................................156, 1464*<br />
Lee, Y ............................................ 1454, 2290<br />
Lee-Brotherton, V M ...........................1408*<br />
Lefebvre, A .............................................1190<br />
Lefkowitz, L J ........................................ 1278<br />
Lehman-McKeeman, L D ..................1680*,<br />
........................................................ 1768, 1930<br />
Lehmann, L .......................................... 1311*<br />
Lehmler, H ..................................1082*, 2054<br />
Lehmler, H J ................................ 1487, 1488<br />
Lehto, M ................................................. 1885<br />
Lei, H ...................................................... 1599<br />
Lei, Y ........................... 434*, 435*, 454, 1452<br />
Leibold, E ............................................... 1563<br />
Leimgruber, R M .................................... 532<br />
Lein, P .................................................... 1084<br />
Leino, M ................................................. 1885<br />
Leiter, K W ............................................... 782<br />
Leitner, H ............................................... 1853<br />
Lemasters, J J ......................................... 1053<br />
Lemay, F ................................................... 244<br />
Leon-Chavez, B ..................................... 1619<br />
Leonard, J ..................................... 114, 2131*<br />
Leone, A M ........................... 569, 755, 1174*<br />
Lepape, A ............................................... 2032<br />
LePoire, D ................................................ 332<br />
Lepoittevin, J ..........................................1197<br />
Lerch, E W ..............................................1311<br />
Lernmark, A .......................................... 1271<br />
Lerondel, S ............................................ 2032<br />
LeSauteur, L .................................... 174, 195<br />
Lesch, C A ................................................ 530<br />
Leseman, D C ........................................ 1446<br />
Leseman, D L .......................................... 929<br />
Letizia, C ............................................... 1183*<br />
Leung, H W ............................................. 257<br />
Leverette, R ................................1517, 2229*<br />
Leverette, R D ........................................1186<br />
Levin, A A .................................................. 16<br />
Levin, E D ...........................965, 1069, 1070*<br />
Lewandowski, T A ....................... 284, 1071<br />
Lewandowski, T A ................................384*<br />
Lewis, A M ............................................ 1513<br />
Lewis, D ................................................... 843<br />
Lewis, D N ..............................................844*<br />
Lewis, E M ............................................... 544<br />
Lewis, J ..................................................... 162<br />
Lewis, J A ..............................................2017*<br />
Lewis, J M ...............................................952*<br />
Lewis, K ................................................... 374<br />
Lewis, L .................................................... 422<br />
Lewis, L M ............................................. 1260<br />
Lewis, M W ............................................. 601<br />
Lewis, R W ............................................ 1638<br />
Lewis, S .................................................1244*<br />
Lewis, S M ............................................. 1813<br />
Lewis-Michl, E ...................................... 1093<br />
Lhote, N ................................................ 1175*<br />
LI, A P ................................ 485*, 1927, 2215*<br />
Li, G .......................................590, 593*, 1534<br />
Li, G L ..................................................... 1301<br />
Li, J .........................................814, 984*, 1865<br />
Li, J G ........................................................ 594<br />
Li, K M ................................................... 1601<br />
Li, L ..................................... 1543, 1788, 2205<br />
LI, Q ...............................................440*, 2274<br />
Li, T ........................................................ 1275<br />
Li, W ............................574, 941, 1603, 2120*<br />
Li, Y ..............................98*, 523, 1814, 1827,<br />
................................... 1833*, 1834, 1847, 2117<br />
Li, Z ...............................................705*, 1905<br />
Li, L ......................................................... 2279<br />
Lian, J B .......................................1031, 1032*<br />
Liao, G ...................................................... 348<br />
Liao, K H ........................................403*, 865<br />
Liao, S ....................................................... 193<br />
Lichtveld, K ............................................. 942<br />
Liebler, D C .............................. 1320*, 1325*<br />
Lieckfield, R ............................................ 419<br />
Lightfoot, R ............................................. 905<br />
Lili, T ...................................................... 1402<br />
Lim, F ........................124*, 1375, 1736, 1739<br />
Lim, K ...................................................... 150<br />
Lim, L ....................................................... 287<br />
Lim, Y ..................................................... 1217<br />
Lima, A ..................................................... 879<br />
Limaye, P ................................................... 59<br />
Limaye, P B ......................................77*, 842<br />
Lin, G ...................................................... 1264<br />
Lin, P ...................................................... 1724<br />
Lin, T ...............................130, 548*, 554, 555<br />
Lin, Y ...................................................... 1096<br />
Linak, W P ............................................. 1214<br />
Lind, M P ................................................679*<br />
Lindeblad, M ......................................... 2026<br />
Linden, J ................................................2042*<br />
Lindsay, D ................................................ 887<br />
Lindstrom, A B ...................................... 1232<br />
Lingenfelter, R A ..................................1290*<br />
Linney, E ................................................ 1581<br />
Linnum, A L .......................................... 1746<br />
Linscombe, V A ..................................... 2224<br />
Lipinski, R J ............................................ 110*<br />
Lippmann, M ........................................ 1453<br />
Lipscomb, J C .....................................9*, 377<br />
Lipsky, M ......................................1159, 1823<br />
Lipsky, M M ...........................................1156<br />
Little, P B ............................................... 1091<br />
Liu, D .................................... 711, 817, 1869*<br />
Liu, F ...................................................... 1495<br />
Liu, H ..................................................... 1807<br />
Liu, J .........................58, 136*, 138, 144, 582,<br />
........................... 593, 694, 1817, 1951*, 2274*<br />
Liu, K .............................................. 682, 1729<br />
Liu, L ...................................................... 1541<br />
Liu, S ...................................................... 1844<br />
Liu, X ............................................... 115*, 569<br />
Liu, H ....................................................1573*<br />
Llorens, J ...............................................1092*<br />
Lloyd, R S .............................................. 1042<br />
Lloyd, S .................................743*, 745, 2014<br />
Lobenh<strong>of</strong>er, E K .......................................119<br />
Lock, E A ...........................2130*, 2137, 2139<br />
Lockley, D .............................................. 2173<br />
Lodestro, C ................................................ 60<br />
Loehle, J A ............................................1266*<br />
Loehlein, D ............................................ 1269<br />
Logue, B A ..............................................795*<br />
Lohitnavy, M ........................................... 849<br />
Lohitnavy, O .................................. 849, 1306<br />
Lohnes, K J ............................................ 1556<br />
Lohrke, S ................................................ 1883<br />
Lohrke, S L .............................................. 783<br />
Lohrke, S R .............................................. 888<br />
Loizou, G ................................................. 681<br />
Lombard, C A .........................................368*<br />
London, L .............................................1334*<br />
Long, H .................................................. 1266<br />
Long, P ................................................... 2200<br />
Looney, J R ............................................... 848<br />
LoPachin, R M .....................................1546*<br />
Lopez, P ................................................... 252<br />
Lopez-Carrillo, L .................................... 427<br />
Lord, J L ................................................ 2119*<br />
Lord, P ...........................................1174, 2291<br />
Lord, P G .......................................... 569, 755<br />
Lorenzana, R M ...................................... 155<br />
Lotti, M .................................................. 1967<br />
Loucks, E ..............................................2260*<br />
Louden, C ...................................... 824, 1843<br />
Louden, C S ................................................. 6<br />
Louderback, M ...................................... 1499<br />
Lough, J W ............................................. 2246<br />
Loughrey, H .......................................... 1780<br />
Lovett, C ................................................ 1309<br />
Lovik, M .......................................... 450, 453<br />
Lowit, A .............................870, 1001*, 1298,<br />
.............................................. 1939, 1940, 1941<br />
Lowndes, H E ......................................... 610<br />
Lowney, Y .............................................2084*<br />
Lowry, D F ............................................. 1705<br />
Lu, B ................................................. 535, 559<br />
Lu, H .......................................................570*<br />
Lu, S ........................................................ 2205<br />
Lu, Y ........................................................849*<br />
Lucas, S .................................................... 455<br />
Lucchini, R .............................................. 597<br />
Luckie, C ................................................ 2274<br />
Lucot, J B .................................................. 789<br />
Luderer, U ..............................................1117<br />
Ludewig, G ............................................ 2058<br />
Luebke, R ......................................... 512, 889<br />
Luesch, H ............................................... 1721<br />
Luijten, M .............................................1490*<br />
Luke, A M ...............................................193*<br />
Lumley, L ................................................. 785<br />
up-to-date information at www.toxicology.org 235<br />
Lumley, L A ....................................776*, 787<br />
Lumpkin, C ........................................... 1036<br />
Lumpkin, C K ....................................... 1737<br />
Lumpkin, M H ...............................402, 419*<br />
Lunchick, C ................................... 870, 1297<br />
Lund, A K .....................................846, 1837*<br />
Luo, B ..................................................... 1924<br />
Luo, H ................................ 1308, 1309, 1595<br />
Luo, W ..................................................2195*<br />
Luo, X ....................................560, 577, 1603*<br />
Lusis, A J ...................................... 1373, 1949<br />
Luster, M I ............................................... 705<br />
Luu, T C ..................................................... 98<br />
Luukinen, B ........................................... 1481<br />
Luyendyk, J P .......................................1930*<br />
Lynch, B S .............................................. 1408<br />
Lynch, C M ...........................................1350*<br />
Lynch, J P ................................................145*<br />
Lynch, K M .............................................. 536<br />
Lynch, M .................................................. 461<br />
Lynes, M A ............................... 196, 507, 894<br />
Lyng, G D .............................................1083*<br />
Lyons, R M ...............................................14*<br />
Lyons-Darden, T ....................................512*<br />
Lysytsya, A ........................ 2284, 2294, 2296<br />
Lyubimov, A .............. 489, 1782, 1785, 2026<br />
M<br />
Ma, D .................................................201, 711<br />
Ma, J K ..................................................... 212<br />
Ma, J Y .....................................................212*<br />
Ma, P ...................................................... 2071<br />
Maatta, J ................................................1885*<br />
Mably, T A ............................................1781*<br />
MacGregor, J T ................................... 11, 25*<br />
Machado, A F .........................................1168<br />
Machida, N .....................................211, 1793<br />
Maciag, A ............................................... 1013<br />
Maciejczyk, P ........................................ 1453<br />
MacIntosh, S .......................................... 1307<br />
Mackay, W J ........................................... 2231<br />
MacKenzie, B A ....................................... 772<br />
MacKenzie, C ...........................................911<br />
MacKenzie, S A ....................................1405*<br />
Mackie, J ................................................ 1402<br />
Mackie, R S .............................................. 769<br />
MacNee, W .............................................. 437<br />
MacNicoll, A ........................................... 681<br />
MacPhail, R ........................................... 1934<br />
MacPhail, R C ..................1335, 1437, 1438*<br />
Maczka, C ................................................ 242<br />
Maddaloni, M A ....................................327*<br />
Madden, E F .........................................2136*<br />
Madden, M .............................................. 447<br />
Madden, M C .....................457*, 1294, 1917<br />
Maddox, J ................................................ 684<br />
Maddox, J F ..................................... 69, 1930<br />
Madenspacher, J H ..............64, 1005, 1900*<br />
Madhukar, B V .............................187, 1361*<br />
Madl, A ........................................... 410, 411*<br />
Madren-Whalley, J ........................ 484, 1628<br />
Madrigal, A ........................................... 1293<br />
Maeda, K ................................................. 278<br />
Maeda-Nakamura, K ........................... 1928<br />
Maekawa, A ............................................ 763<br />
Maekawa, M ........................................... 556<br />
Maeng, S ................................................ 1454<br />
Magnuson, S R .......................................... 45<br />
Mahadevan, B ..................1499, 1814*, 2272<br />
Maher, J M ..............................564, 815, 821*<br />
Mahle, D .................................................526*<br />
Mahringer, A ......................................... 1735<br />
Maibach, H .............................................. 482<br />
Maibach, H I .......................................... 2084<br />
Maier, A .................373, 375*, 379, 381, 1477<br />
Maier, C ...................................................873*<br />
Maier, C C ................................................ 179<br />
Maier, W ................................................ 1916<br />
Mainor, C B .......................................... 1111*<br />
Maitra, R ...............................................1557*<br />
Majkova, Z ...........................................1838*<br />
Major, M A ............................................. 1238<br />
Major, V ................................................. 1334<br />
Mak, N K ..................................... 1600, 1601<br />
Makhaeva, G F .........192, 1936*, 1937, 1938<br />
Maki, A ............................................. 60, 1046<br />
Maki-Paakkanen, J ................................. 749<br />
Makin, A ...............................................2028*<br />
Makinodan, F ........................................ 1251<br />
Makris, S .......................................... 378, 977<br />
Makris, S L ..........................................3, 380*<br />
Makusky, A J ......................... 64, 1005, 1900<br />
Makwana, O ........................ 204, 1445, 1964<br />
Makynen, E A ........................................ 1746<br />
Malard, J M ............................................. 122<br />
Malarkey, D ............................................. 844<br />
Maldonado, H ....................................... 1539<br />
Maleeff, B E ............................................. 536<br />
Malekafzali, A ....................................... 1444<br />
Malinczak, C Y ........................................ 180<br />
Malisch, R .............................................. 2072<br />
Malley, L A ....................................951*, 1405<br />
Mally, A .................................................1799*<br />
Malmfors, T ............................................251*<br />
Malstrom, S ........................................... 1444<br />
Malygin, V V ............192*, 1936, 1937, 1938<br />
Manautou, J ........................................... 1921<br />
Manautou, J E ........................67, 815, 1051*<br />
Manca, D A .......................1258*, 2077, 2081<br />
Manciaux, X .........................................2032*<br />
Mandel, H G ..........................................1136<br />
Mandsager, J ........................................... 492<br />
Manetz, S ..........................................810, 811<br />
Manganaro, D M .................................. 2106<br />
Mann, K K ....................................688*, 2293<br />
Mansour, M ...................... 1139*, 1140, 2112<br />
Manthei, J ................................................ 793<br />
Manthei, J H ............................................ 788<br />
Manzo, L .....................................1055, 2051*<br />
March, T H .............................................1141<br />
Marcus, C .................................89, 325*, 715<br />
Marcus, C B ............................................. 724<br />
Marek, K L ............................................. 1988<br />
Marin, H E ................................................55*<br />
Marino, A ............................................... 1621<br />
Marinovich, M ............................ 1888, 2247<br />
Maritnez, J E .......................................... 1371<br />
Maritz, G S ............................................1646*<br />
Markham, D A .......................................1176<br />
Marlatt, J L ..................................1314, 1315*<br />
Marlowe, J L ...........................................104*<br />
Marnett, L .............................................1324*<br />
Maronpot, R ............................................ 672<br />
Maronpot, R R ...................................... 1302<br />
Marquardt, H ........................................ 1996<br />
Marr, R ..................................................... 199<br />
Marron, J ................................................ 1046<br />
Marroquin, L D ......................................488*<br />
Marsden, E ............................................ 1429<br />
Marsh, T ......................................1506, 1821*<br />
Marshall, P .............................................. 169<br />
Marshall, R S ................................ 966, 1335,<br />
.............................................. 1939, 1940, 1941<br />
Marston, C P ......................................... 1814<br />
Martha, M M ......................................... 2222<br />
Martin, D ................................................1132<br />
Martin, E J .............................................2278*<br />
Martin, G ............................................... 2135<br />
Martin, K R .................................1044, 1496*<br />
Martin, L ...............................................1373*<br />
Martin, M ................................................. 300<br />
Martin, N J ............................................. 1009<br />
Martin, P ...............................................1294*<br />
Martin, R J ............................................. 1566<br />
Marty, M A ................1519, 1521, 2109, 2111<br />
Marty, M S ..............................................269*<br />
Martínez, E ............................................ 1708<br />
Marusanov, V E ...................................... 468<br />
Maruyama, W ........................................393*<br />
Marvanova, M ...................................... 1973<br />
MaryBeth, D E ...................................... 1299<br />
Mash, E A ............................... 146, 147, 2275<br />
Masjedizadeh, M .................................... 348<br />
Mason, A ................................................ 1590<br />
Mason, A M ............................................. 403<br />
Mason, E .......................................... 776, 787<br />
Mason, R P .............................................. 759<br />
Mason, S ...................914, 1457*, 1458, 2024<br />
Massart, C .............................................. 1039<br />
Massey, E D ........................................... 2013<br />
Massey, T E ............................ 737, 935, 2265<br />
Masson, M ..............................................905*<br />
Master, Z R .............................................354*<br />
Masters, K .............................................2033*
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Masters, O ............................................. 1042<br />
Masucci, M E ......................................... 2230<br />
Matherly, L H ........................................ 1822<br />
Mathew, L K ...............................2241*, 2242<br />
Mathews, J ............................................... 732<br />
Mathieu, L ..............................................487*<br />
Mathis, M .............................................. 1498<br />
Matis, S .................................................... 508<br />
Matson, C W ......................................... 1593<br />
Matson, K L ............................................. 773<br />
Matsuda, Y ............................................ 1471<br />
Matsumoto, H ......................................1379*<br />
Matsumoto, M .....................281, 816*, 2277<br />
Matsumura, F ......... 1164, 1442, 1753, 2041*<br />
Matsuo, J .................................................. 826<br />
Matsushita, T ...............................562*, 1380<br />
Mattes, W B ............ 753, 1829, 1968*, 1972*<br />
Matthew, B S ........................................... 866<br />
Matthews, E .......................................... 2204<br />
Matthews, J ...........................................1365*<br />
Mattie, D ................................................ 2039<br />
Mattie, D R .................................. 1305, 2078<br />
Mattingly, C ..........................................1706*<br />
Mattrey, R F ............................................1103<br />
Matunis, M J ...........................................658*<br />
Mauderly, J L ........................................... 444<br />
Maurissen, J P ..............................269, 1678*<br />
Mayeno, A N ........................................1300*<br />
Mayer, A M ...........................................1436*<br />
Mayer, J .................................................2204*<br />
Mayk, A ...................................................1107<br />
Maynard, A D ........................................649*<br />
Maynaud, M .......................................... 1240<br />
Mayo, P R .............................................. 1255<br />
Mayol, N ................................................ 1539<br />
Mays, D .................................................... 408<br />
Mazor, K A ............................................1093*<br />
McAtee, B L ...................... 1263, 1272*, 1811<br />
McAvoy, S ........................................ 776, 787<br />
McCabe, M J ........ 134, 689, 690, 1877, 1884<br />
McCaffrey, R J ....................................... 1988<br />
McCarty, J D ............................................ 978<br />
McCarver, D G ........................................ 259<br />
McClain, C J .......................................... 1876<br />
McClellan, R O ......................... 1674*, 1677*<br />
McClure, P ............................... 406, 407, 768<br />
McClure, P R ........................................... 399<br />
McCollum Lehmann, G ........................134*<br />
McConnachie, L .....................................225*<br />
McConnachie, L A ................................ 1859<br />
McCormack, J F ...................................1354*<br />
McCormick, D L ............... 1776, 1777, 1778<br />
McCoy, R ............................................... 1671<br />
McCracken, K A .................................... 1812<br />
McCue, J ................................................ 1865<br />
McCullough, S S ....................................... 68<br />
McCurdy, S A ........................................ 1278<br />
McDaniel, K .......................................... 1940<br />
McDaniel, K L ............................. 1078, 1941<br />
McDaniel, L ..................................... 293, 361<br />
McDermott, M J .................................... 1288<br />
McDiarmid, M .............................165, 1664*<br />
McDiarmid, M A ...................................163*<br />
McDonald, A ......................................... 1934<br />
McDonald, J ...................199, 444*, 455, 960<br />
McDonald, J D ...................................... 1017<br />
McDonald, T ......................................... 1290<br />
McDonald, T A ...............................313*, 396<br />
McDonald, T J ..................... 524, 1593, 2270<br />
McDonough, J ................................. 776, 785<br />
McDonough, J H ..................................... 787<br />
McDougal, J N ...................344*, 2178, 2179<br />
McElroy, W .............................................1119<br />
McElvania TeKippe, E ..........................928*<br />
McGarrigle, B P .................................... 2157<br />
McGee, J ................................................... 441<br />
McGinnis, P ..................... 155, 406, 407, 768<br />
McGinnis, P M ........................................ 399<br />
McGlothan, J L .................................. 52, 678<br />
McGrath, A M ................................. 64, 1900<br />
McGraw, J E ............................................. 734<br />
McGuire, J ........................................ 776, 787<br />
McGuire, J M ................................... 773, 775<br />
McHowat, J ........................................... 2125<br />
McIntyre, B .............................................798*<br />
McKallip, R ............................................877*<br />
McKarns, S C .......................................1872*<br />
McKee, R .................................................264*<br />
McKee, R H ............................................275*<br />
McKelvey, K .............................................. 71<br />
McKim, Jr., J M ................................ 80, 1932<br />
McKinney, W ................................. 933, 1468<br />
McKinney, W J ...............................506, 635*<br />
McLain, E ............................................... 2217<br />
McLanahan, E D ..................................2039*<br />
McLellan, C ................................. 2098, 2103<br />
McMahon, J M .............................. 848, 1751<br />
McMahon, T ...........................................241*<br />
McManus, B E ......................................... 940<br />
McMartin, K ...........................................2117<br />
McMartin, K E ........................................ 857<br />
McMaster, S ........................................... 1277<br />
McMillan, D C .............................. 207, 1559<br />
McMillan, J M ..........................................71*<br />
McMillian, M .........................................1174<br />
McMillian, M K .............................569*, 755<br />
McNally, A ......................................131*, 600<br />
McNeely, S C ..................................689*, 690<br />
McNett, D A .................................. 848, 1237<br />
McPhail, B ..............................................956*<br />
McQueen, C A ......................................1977*<br />
McQuown, J ...................................86*, 1658<br />
Meacham, C A ......................................1547*<br />
Meade, B J ...........................1210, 1211, 1713<br />
Means, J C ...................................... 565, 2055<br />
Meckley, D R .................... 1185, 1515*, 1516<br />
Medeiros, M .............................................119<br />
Medina, I M ..........................................2166*<br />
Medrano, T .............................................1113<br />
Medrek, S ............................................... 2195<br />
Medvedovic, M ....................................... 103<br />
Meek, E C .........................1299, 1946*, 1947<br />
Meeker, L ................................................. 949<br />
Meeks, R G .............1507, 1508, 1509, 1510*<br />
Meerdink, G L ....................................... 1313<br />
Meeuwen, J V .......................................1734*<br />
Mehendale, H M .............59, 62, 73, 75*, 77,<br />
....................................... 731, 842, 1909, 1910,<br />
.............................................. 2137, 2138, 2139<br />
Mehlman, T ............................................. 882<br />
Mehta, H ................................................ 1958<br />
Mei, H ...................................................... 527<br />
Mei, N ................................. 747, 1565, 2206,<br />
.............................................2217, 2218*, 2220<br />
Meier, H L ...............................................778*<br />
Meijer, D K ............................................. 1913<br />
Meissner, A .............................................. 519<br />
Meistrich, M L ......................................... 541<br />
Mekhtiev, A ........................................... 1290<br />
Meldrum, M .......................................... 1093<br />
Melendez, K F ......................................... 302<br />
Mendez, E ................................................ 380<br />
Mendez, J ............................................... 1862<br />
Mendez, L .............................................. 1448<br />
Mendrala, A L ....................................... 1242<br />
Mendrick, D L ....................................... 1972<br />
Mendy, A J ......................... 1050, 1766, 1920<br />
Menegola, E ........................................... 2247<br />
Meng, Q ..........................................122*, 919<br />
Meng, Q R ............................................. 1705<br />
Meng, R ...................................................921*<br />
Meng, X .................................................. 1726<br />
Mercado Feliciano, M .........................1749*<br />
Mercer, P .................................................. 443<br />
Mercer, R R .....................................701, 702*<br />
Meredith, C ........................................... 2160<br />
Merema, M T ......................................... 1913<br />
Mergler, D .............................................. 1334<br />
Merlino, G ............................................. 1803<br />
Merrick, A .............................................. 1538<br />
Merrick, B .............................................. 1709<br />
Merrick, B A .........................64, 1005*, 1900<br />
Merrill, E A ...........................................1305*<br />
Merrill, J ......................................... 194, 1233<br />
Merrill, J W ...........................................1234*<br />
Mertens, J W .......................................... 1510<br />
Messer, D ............................................... 2069<br />
Metzler, M ..............................................1311<br />
Meuling, W ............................................ 2087<br />
Meurrens, K ............................................ 924<br />
Meyer, D A ............................................1953*<br />
Meyer, J .................................................... 687<br />
Meyer, K E ............................................... 808<br />
Meyer, S ................................................... 492<br />
Meyer, S A ...................................... 736, 2167<br />
Meza-Velazquez, M ................................ 253<br />
236<br />
Michaux, A .............................................. 174<br />
Michel, C ................................................. 118*<br />
Michoudet, C ........................................ 2135<br />
Micsenyi, A ............................................ 1052<br />
Middaugh, D ......................................... 1095<br />
Mielke, H ............................................... 2071<br />
Mielke, H W ......................................... 1160*<br />
Mielke (Emeritus), P .............................1160<br />
Miettinen, H M ....................................... 679<br />
Migliaccio, C T .....................................1890*<br />
Mikami, N ............................................... 750<br />
Milano, J ........................................573*, 1779<br />
Milano, S ................................................ 2032<br />
Milatovic, D ..................................215*, 1000<br />
Milatovic, S ............................................ 1000<br />
Miles, S L ..............................................2122*<br />
Milicic, I ................................................... 557<br />
Millecchia, L .......................................... 1443<br />
Miller, A L ................................................ 782<br />
Miller, B G ................................................ 681<br />
Miller, B J ..................................... 2185, 2187<br />
Miller, C A ..............................................503*<br />
Miller, D ................................... 776, 787, 793<br />
Miller, D B ............... 48, 775, 788, 794, 1540<br />
Miller, F ...................................................2110<br />
Miller, F J ............................................... 1304<br />
Miller, G W ...... 973, 1097, 1529, 1545, 1961<br />
Miller, H L ....................................... 690, 691<br />
Miller, J A ..............................................1536*<br />
Miller, K P ...................................1367*, 2153<br />
Miller, M D ............................................ 1519<br />
Miller, M L ..............................227, 955, 1165<br />
Miller, M S ............................................. 1792<br />
Miller, N D ............................................1938*<br />
Miller, R T ................................................ 584<br />
Miller, S .................................................... 422<br />
Miller, T .......................................... 263, 1576<br />
Miller, T J ....................................1513*, 1842<br />
Miller, T R .....................................229, 1860*<br />
Miller, W H .................................... 688, 2293<br />
Millett, S ................................................. 1634<br />
Milligan, M ............................................ 1637<br />
Mills, J B ................................................... 357<br />
Mills, L J ................................................1745*<br />
Mills, N L ................................................437*<br />
Millsap, D S ........................................... 2245<br />
Milton, J ................................................. 1046<br />
Min, E ..................................................... 1853<br />
Min, K N .......................................... 202, 720<br />
Min, W ..................................................... 467<br />
Minakawa, A ........................................... 176<br />
Minard, K R ............................................. 347<br />
Ming, X .................................................... 983<br />
Minnick, T A .......................................... 2174<br />
Mino, T ............................................. 980, 981<br />
Minobe, Y .............................................. 1727<br />
Minsavage, G D .....................................182*<br />
Mioduszewski, R .................... 776, 785, 793<br />
Mioduszewski, R J ........................ 773, 775,<br />
............................................ 786, 787, 788, 794<br />
Miracle, A .............................................1583*<br />
Mirajkar, N ................................................ 51<br />
Miranda, C L ......................738*, 2019, 2020<br />
Miranda, S R ..........................................736*<br />
Mirsalis, J ....................................... 801, 1095<br />
Mirsky, M L ............................................. 532<br />
Mishima, K .............................................. 954<br />
Mishin, V ............................................... 1398<br />
Mishin, V M ............................................ 217<br />
Mishra, N ........................................... 21, 189<br />
Misra, M ................... 923, 1186*, 1517, 2229<br />
Mitchell, K A ........................................1362*<br />
Mitkus, R J .........................315*, 318*, 1451*<br />
Mitra, M S .................................................62*<br />
Mitsumori, K ..................................211, 1793<br />
Miyagawa, M ........................................ 1080<br />
Miyagishima, T ....117, 561, 562, 1901, 1902<br />
Miyajima-Tabata, A ...............................709*<br />
Miyake, T ................................................. 833<br />
Miyamaoto, K ......................................... 423<br />
Miyamoto, M ........................................ 2031<br />
Miyamoto, Y .......................................... 2043<br />
Miyata, E .................................................. 742<br />
Miyaura, H ............................................ 1379<br />
Miyazaki, T ........................................... 1901<br />
Miyazawa, M ................... 1192, 1193, 1194*<br />
Mizoguchi, Y ......................................... 1703<br />
Mizukawa, Y ........................................1902*<br />
Mobio, T M ............................................ 1440<br />
Modi, A .................................................. 2291<br />
Moeller, T A ..........................................2014*<br />
M<strong>of</strong>fett, D ............................ 390, 1560, 2086<br />
M<strong>of</strong>fit, J S ..................................................67*<br />
Moggs, J ............................... 124, 1375, 1739<br />
Moggs, J G ............................................1736*<br />
Mohamadin, A M ..................................... 79<br />
Mohan, S .................................................606*<br />
Mohar, I .........................................225, 1859*<br />
Mohrman, M ......................................... 1717<br />
Moilanen, L H ........................................407*<br />
Moldovan, H M ...................................... 203<br />
Monbaliu, J .............................................. 268<br />
Mondal, M ............................................... 515<br />
Monestier, M ........................................1330*<br />
Moneypenny, C G ...............................2244*<br />
Monforte, J ............................................... 754<br />
Monga, S ................................................ 1052<br />
Monica, Y ................................................159*<br />
Monks, T J .......1801, 2118, 2119, 2275, 2281<br />
Monks, T T .............................................. 823<br />
Monroe, M E ........................................... 918<br />
Monroe, P J .............................................. 108<br />
Monteiro-Riviere, N ............................. 2180<br />
Monteiro-Riviere, N A ........... 1691*, 1697*,<br />
.........................2176, 2181, 2183*, 2184, 2196<br />
Monteith, D ......................................13*, 519<br />
Monticello, T ......................................... 1464<br />
Monticello, T M .................................4*, 915<br />
Montine, T J ................................... 215, 1000<br />
Moon, C ................................................... 717<br />
Moon, H ................................................. 2290<br />
Moore, A .................................................1114<br />
Moore, D A .............................................1150<br />
Moore, D J ..........................124, 1375, 1739*<br />
Moore, D M ................................2201*, 2202<br />
Moore, K .......................................492*, 1557<br />
Moore, M ....................................1025*, 2217<br />
Moore, M M ...........1565, 2216, 2218, 2220*<br />
Moore, N ................................................ 2249<br />
Moorthy, B ............................714*, 756, 1845<br />
Moraga, A .................................................. 43<br />
Moran, A .................................................959*<br />
Moran, J ................................................. 2159<br />
Moran, T H ............................................ 1544<br />
Moreland, J A .......................................... 160<br />
Moreno, M ............................................ 1146*<br />
Moretto, A .............................................. 1967<br />
Moretz, R A ............................................. 788<br />
Morgan, D L .......................................... 1091<br />
Morgan, E T ............................................. 722<br />
Morgan, K .................................................114<br />
Morgan, R ...................................... 519, 1784<br />
Mori, C ..................................... 129, 543, 556<br />
Mori, K ....................................................1611<br />
Mori, S ...................................................... 742<br />
Morikawa, A ....................2064, 2067, 2068*<br />
Morimura, K ................................... 746, 750<br />
Morin, D R ............................................... 359<br />
Morin, J ...................................................446*<br />
Morishita, M .................................... 438, 439<br />
Morita, O ..................................... 1394, 1399<br />
Morita, T .................................................. 700<br />
Mork, A ...................................................853*<br />
Morrall, S W ...........................................1197<br />
Morris, J B ..................................... 2*, 2*, 947<br />
Morris, J E ...............................................238*<br />
Morris, M ......................................... 789, 791<br />
Morris, R W ........................................... 1302<br />
Morris, S .................................................. 810<br />
Morrissey, R .................466, 798, 1186, 1782<br />
Morrissey, R L ..................... 923, 1777, 1778<br />
Morrow, J D ............................................. 207<br />
Morse, J K .............................................. 1945<br />
Morseth, S ........................................ 544, 807<br />
Morsman, J ...................................... 560, 577<br />
Mosadeghi, S ..........................................739*<br />
Mosby, A .................................................320*<br />
Mosby, A C .............................................. 318<br />
Moser, V C ...............389, 1078, 1091, 1335*,<br />
.............................................1939, 1940, 1941*<br />
Mosesso, P ............................................. 1799<br />
Moss, J R .................................................... 52<br />
Moss, O R .....................................517, 1463*<br />
Moto, M .................................................. 211*<br />
Moudgal, C ........................... 285, 383, 1520<br />
Moudgil, B ....................................... 43, 2108<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Moukha, S ................................... 1435, 1440<br />
Mould, A .................................................. 467<br />
Mounho, B ............................................1991*<br />
Mounho, B J ........................................... 1990<br />
Mouton, G ............................................... 879<br />
Mowat, F .................................................. 409<br />
Moya, J ..................................................... 378<br />
Moyer, G ........................................ 484, 1628<br />
Mu, X .....................................................1729*<br />
Mucci, L ..................................................295*<br />
Muccio, D .............................................. 1785<br />
Muehlbauer, P A ....................................337*<br />
Mueller, S O ..........................................1750*<br />
Mueller, W ............................. 478, 948, 2025<br />
Muhammad, F .....................................2176*<br />
Muirhead, E .......................................... 2021<br />
Mukai, M ................................................. 554<br />
Mukhi, S .......................................494*, 1595<br />
Mukhopadhyay, R .................................217*<br />
Mullen, T E ...............................................119<br />
Mumtaz, M ............................................ 2039<br />
Mumtaz, M M ..................................73, 390*<br />
Mun, G ................................. 484, 1628, 2209<br />
Mundandhara, S ..................................... 457<br />
Mundy, W .............................................2057*<br />
Munehito, M ........................................... 423<br />
Muneoka, K ............................................. 954<br />
Muneoka, K T ................................. 988, 989<br />
Mungalachetty, P .................................. 1924<br />
Mungapen, L ........................................... 265<br />
Munro, I C ............................................1673*<br />
Munroe, R C ...........................................1135<br />
Munson, J .............................................. 2186<br />
Murai, T ................................................... 742<br />
Murali, B .................................................... 75<br />
Murali, M ............................................... 1062<br />
Muralidhara, S ..................... 729, 956, 1243,<br />
.............................................. 1245, 2039, 2095<br />
Muramatsu, K ......................................... 708<br />
Murasaki, T ........................................... 1424<br />
Muro-Cacho, C ......................................... 72<br />
Murono, E P ...........................................549*<br />
Murphy, D J ............................................. 339<br />
Murphy, E ........................................ 828, 829<br />
Murphy, G ............................................1441*<br />
Murphy, K A ...........................................102*<br />
Murphy, P A .......................................... 1385<br />
Murphy, V A .............................................. 10<br />
Murr, A S .................................................1119<br />
Murray, A R ..........................701, 702, 2188*<br />
Murray, T F ................................... 960*, 1100<br />
Murrel, R ............................................... 2145<br />
Murrell, R N .................................. 188, 2151<br />
Murthy, G S ..........................................1313*<br />
Murthy, S ................................................. 932<br />
Mus, M ....................................................476*<br />
Musa-Veloso, K ..................................... 1408<br />
Musafia-Jaknic, T .................................. 2019<br />
Muse, W ................................................... 793<br />
Muse, W T ....................................... 775, 788<br />
Musgrove, D ........................................... 362<br />
Musgrove, D L ........................................ 878<br />
Muskhelishvili, L .................................. 1912<br />
Mussali-Galante, P ........................608, 1153<br />
Musselman, I H .................................... 1594<br />
Muthiah, K .............................................. 756<br />
Mutkus, L ................................................ 486<br />
Mutlib, A ................................................ 1049<br />
Muto, N ................................................... 270<br />
Myers, L P ...................................1210, 1713*<br />
Myers, S R .......516, 1259, 1284*, 1285, 1286<br />
Mylchreest, E .......................951, 952, 1686*<br />
N<br />
N, A U .....................................................565*<br />
Nabae, K ...............................................1388*<br />
Nabb, D L .............................231*, 234, 1578<br />
Naciff, J M .............................................1371*<br />
Nadadur, S S ........................................1447*<br />
Nadkarni, P ....................................925, 938*<br />
Nadwodny, K L ...................................... 910<br />
Nagabhushan, M .................................. 1776<br />
Nagai, H .................................................. 130<br />
Nagai, Y ................................................. 2205<br />
Nagao, T ...............117, 561, 562, 1901, 1902<br />
Nagarkatti, M .................. 363, 365, 368, 877<br />
Nagarkatti, P ................................... 365, 990<br />
Nagarkatti, P S ...............363, 368, 877, 991*<br />
Nagase, H .....................................1191, 1318<br />
Nagashima, H ......................................1928*<br />
Nagata, R ........................ 492, 496, 826, 833,<br />
................................................ 834, 1094, 1707<br />
Nagayama, S ..........................................826*<br />
Nagelkerke, N ....................................... 1490<br />
Nagori, A ............................................... 1410<br />
Naito, A ...........................................563, 762*<br />
Najarian, T ............................................... 170<br />
Nakae, D .................................................. 763<br />
Nakagawa, H .......................................... 270<br />
Nakagi, Y ................................................. 604<br />
Nakai, K ........................................... 604, 709<br />
Nakai, M ...............................................1727*<br />
Nakamura, J ............................................ 525<br />
Nakamura, M ........................................ 1388<br />
Nakamura, T ................................799, 1640*<br />
Nakamura, Y ........................................1501*<br />
Nakanishi, K ......................................... 1703<br />
Nakano, K ................................................ 607<br />
Nakayama, H ........................................ 1433<br />
Nakayama, K ................................ 763, 1379<br />
Nakazawa, H ........................................ 2155<br />
Nallapaneni, A .........................................51*<br />
Namorado, M C .....................................1132<br />
Namork, E ............................................... 417<br />
Nanba, T ................................................ 1703<br />
Nandi, S ................................................. 1467<br />
Nanez, A ...............................................2132*<br />
Napolitano, G ....................................... 1830<br />
Naqvi, A ................................................. 1410<br />
Narahashi, T ...............................1962*, 1963<br />
Narayanan, L ........................................ 2039<br />
Narayanan, P K .................................... 1828<br />
Narotsky, M G ........ 1118, 2143*, 2148, 2151<br />
Nascarella, M A ...................................2016*<br />
Nash, J F ..........................................10, 1693*<br />
Naspinski, C .......................................... 1290<br />
Nasreen, N ............................................ 2108<br />
Nass, R ..................................................1973*<br />
Nasser, F A ..................................1936, 1937*<br />
Nath, J ...................................................... 360<br />
Natsoulis, G ..................................521, 1700*<br />
Nau, M ..................................................... 793<br />
Naufal, Z ................................................ 1290<br />
Naumann, B .......................................... 1235<br />
Navarro, L ............................................... 264<br />
Navarro, L E .........................................1504*<br />
Navarro, S .....................................364*, 1420<br />
Navas-Acien, A ....................................... 430<br />
Navetta, K A ...........................................520*<br />
Nayeem, F ............................................. 1922<br />
Nazarenko, D A .................................... 2046<br />
Ndountse-Tchapda, L .......................... 1863<br />
Nduaka, C I ............................................540*<br />
Neale, J R ............................................... 1266<br />
Nealley, E W .................................... 777, 782<br />
Nebert, D W .................227, 955, 1165, 1599<br />
Needham, L ........................................... 1291<br />
Needham, L L ......................................1340*<br />
Neff-LaFord, H ......................................874*<br />
Nelms, L ..........................................535*, 540<br />
Nelson, C ..................................... 1747, 2204<br />
Nelson, D M ...............................1768*, 1930<br />
Nelson, G ........................... 2144, 2146, 2268<br />
Nelson, J ................................................... 798<br />
Nelson, S .................................................. 813<br />
Nemanich, R J ............................. 2183, 2184<br />
Nemec, A A .............................................1162<br />
Nemec, M ................................................ 978<br />
Nemec, M D ...................................239*, 240<br />
Nemeti, B ........................................140*, 149<br />
Nesnow, S .................................... 2147, 2268<br />
Nesnow, S C ...................... 2144, 2146, 2149<br />
Nestmann, E R ...................................... 1408<br />
Nethery, K A ............................................ 469<br />
Neuforth, A E .......................................... 526<br />
Newbold, R ..........................260, 1114, 1370<br />
Newby, D E ............................................. 437<br />
Newell - McGloughlin, M ..................1670*<br />
Newham, P .................................. 1465, 1466<br />
Newland, N ........................................... 2013<br />
Newman, B ...........................................1553*<br />
Newport, S W ................................69*, 1930<br />
Newsted, J L .......................................... 2150<br />
Ng, S P .......................................22, 880, 881*<br />
up-to-date information at www.toxicology.org 237<br />
Nguyen, H ............................................. 2195<br />
Nguyen, P .............................................. 1591<br />
Nguyen, T ................................................ 803<br />
Nicholls, A W .......................................... 491<br />
Nicholls, I M .............................................. 61<br />
Nichols, A C .........................................1589*<br />
Nichols, C .............................................. 1973<br />
Nichols, H P ...................... 2143, 2148, 2151<br />
Nichols, J W ......................1579, 1580*, 2254<br />
Nichols, R C ............................................ 137<br />
Nicks, D K ............................................. 1289<br />
Nicolescu, A C ........................................935*<br />
Nie, A Y ................................. 569, 755*, 1174<br />
Niedzwiecki, A ..................................... 1494<br />
Nieh<strong>of</strong>, M ...............................................1173<br />
Nieh<strong>of</strong>f, M ....................................948, 2025*<br />
Niemuth, N A ............................. 2201, 2202<br />
Nierkens, S .................................... 903, 1205<br />
Nihart, V M ........................................... 1278<br />
Nihlen, A .................................................. 868<br />
Niino, N ................................................... 708<br />
Nijmeijer, S .................................. 1747, 1748<br />
Nikolskaya, T ........................................ 1378<br />
Nikolsky, Y .................................. 1377, 1378<br />
Nikoskaya, T ......................................... 1377<br />
Nines, R ................................................. 1486<br />
Nipwoda, M T ........................................ 777<br />
Nishikawa, A ....................1406*, 1428, 1861<br />
Nishikibe, M ............................................ 176<br />
Nishimura, H ........................................ 2142<br />
Nishimura, M .......................................... 708<br />
Nishimura, N .......................................2142*<br />
Nishimura, T ......................................... 2155<br />
Nishino, M ............................................. 1388<br />
Nitta, H .................................................1901*<br />
Nixon, P ................................................... 374<br />
Noailles, P H ......................................... 1544<br />
Noakes, J ...............................743, 744, 1638*<br />
Noda, S .................................................. 1727<br />
Nodikum-M<strong>of</strong>for, F ................................ 718<br />
Nogi, A ................................................... 1703<br />
Nohara, K .....................................130, 2043*<br />
Noisel, N .......................................432*, 2156<br />
Noker, P ................................................... 466<br />
Nolan, J P ................................................. 433<br />
Nomura, M .............................................. 270<br />
Nong, A ...........................................259*, 851<br />
Nord, P ..................................................... 352<br />
Nordone, A J .............................................44*<br />
Noreault, T L ..........................................137*<br />
Noriega, N ..................................1374*, 1744<br />
Norimura, T .......................................... 2206<br />
North, C M ............................................ 1930<br />
Norton, D ............................................... 2185<br />
Norton, K ..........................1457, 1458*, 1460<br />
Norwood, A B ............................. 1955, 1956<br />
Novack, D .............................................1033*<br />
Novack, D J ........................................... 1031<br />
Nowak, P ............................ 478*, 1105, 2025<br />
Nowakowski, M ..................................... 540<br />
Nozaki, K ................................................. 812<br />
Nuber, D C ...........................................1397*<br />
Nunez, B A .............................................. 845<br />
Nurkiewicz, T R ..................................1443*<br />
Nye, S ....................................................1897*<br />
Nygaard, U C .................................450*, 453<br />
Nyland, J F .............................................879*<br />
Nylander-French, L A ...........................500*<br />
Nyska, A ................... 33, 441, 670, 779, 784,<br />
..................................828, 829*, 843, 844, 878,<br />
.................1107, 1506, 1821, 1826, 2035, 2070<br />
Nyska, M ................................................. 844<br />
O<br />
O’Brien, E .....................................2113, 2115<br />
O’Brien, P J ............................................ 1926<br />
O’Brien, T J ........................................... 1136*<br />
O’Callaghan, J ..................1056, 1057, 1987*<br />
O’Callaghan, J P .................... 48, 1223, 1540<br />
O’Connor, E ............................................. 462<br />
O’Connor, J C .......................................... 234<br />
O’Dell, S K ............................................. 2182<br />
O’Hagan, S ............................................ 1392<br />
O’Hara, K A .......................................... 1133*<br />
O’Kane, J ................................................ 1262<br />
O’Keefe, M ............................................ 1386<br />
O’Keefe, R ................................................ 695<br />
O’Malley, B W ........................................291*<br />
O’Malley, M ..................................... 776, 787<br />
O’Neill, A O ............................................. 951<br />
O’Neill, D F ........................................... 1401<br />
Oberdoerster, E ....................................1594*<br />
Oberdorster, G ........................ 443, 449, 698<br />
Obert, L A .............................................1916*<br />
Obi, E ...................................................... 1439<br />
Oblak, L ................................................. 1553<br />
Obourn, J D ........................................... 1802<br />
Odin, M ...........................................399, 406*<br />
Oe, T ....................................................... 1006<br />
Oeda, K .................................................... 750<br />
Ogasawara, T ........................................ 1388<br />
Ogata, H ................................................... 709<br />
Ogawa, K ................................................. 765<br />
Ogawa, T ................................954, 988*, 989<br />
Ogden, L ............................................... 2112*<br />
Ogden, M ..............................................1287*<br />
Oguma, E ....................................... 423, 1610<br />
Ogunmosin, O ........................................ 622<br />
Ogura, M ............................................... 1703<br />
Ogura, R ................................................ 1399<br />
Oh, D .......................1531, 2165*, 2168, 2169<br />
Oh, K .................................. 1427, 1524, 2168<br />
Oh, S ............................................. 1261, 1454<br />
Ohno, Y .................................................... 709<br />
Ohta, E ..................................................... 176<br />
Ohtake, N ................................................ 175<br />
Ohtani, K ................................................. 542<br />
Ohtsuki, K ............................................. 1501<br />
Oishi, Y ........................................ 1793, 2277<br />
Oka, H .................................................... 2213<br />
Okada, M ............................................... 1251<br />
Okajima, M .............................................. 700<br />
Okamoto, H ........................................... 1318<br />
Okamoto, K ............................................515*<br />
Okamura, M ................................. 211, 1793*<br />
Okerberg, C ........................................... 1916<br />
Okino, M ...............................858, 870*, 1298<br />
Okuno, Y ................................................ 1730<br />
Oldham, M ............................................ 1448<br />
Oldham, M J ............................................ 926<br />
Olin, S ......................................245, 261*, 386<br />
Olinga, P ...................................... 1913, 1914<br />
Oliveira, P ................................................ 206<br />
Oliver, J .................................................. 1375<br />
Oliver, J R ..................................................78*<br />
Oliver, M .................................................. 165<br />
Olivero-Verbel, J ..................................1708*<br />
Olivier, B N ............................................ 2030<br />
Olsen, G ......................................1236, 1798*<br />
Olsen, H ................................................. 1828<br />
Olsen, L .................................................... 413<br />
Olson, G R ............................................. 2187<br />
Olson, J J ................................................ 2107<br />
Olson, J R ..........................2038, 2045, 2157*<br />
Olson, M J .......................................372, 472*<br />
Omdahl, J ................................................. 715<br />
Omdahl, J L ............................................. 724<br />
Omiecinski, C ............................... 286*, 290*<br />
Ommen, B .............................................. 1319<br />
Omura, K ............................................... 2277<br />
Ondov, J M ............................................ 1451<br />
Ono, H ...................................................... 989<br />
Ono, K .................................................... 2063<br />
Onose, J .................................................. 1503<br />
Opanashuk, L ........................................ 1088<br />
Opanashuk, L A ...................................... 223<br />
Oppenheimer, S F ................................. 1299<br />
Oquendo, I ............................................ 2219<br />
Oravitz, M S ............................................ 778<br />
Orberg, J ................................................... 679<br />
Ordonez-Librado, J ................................ 608<br />
Ordonio, R ............................................... 473<br />
Oreffo, V .................................................. 508<br />
Orehek, M ................................................ 793<br />
Orisakwe, O E ......................................1439*<br />
Orito, K ...................................................954*<br />
Orozco, J .................................................157*<br />
Orphanides, G .................... 124, 1375, 1739<br />
Orr, J L .....................................................1137<br />
Orr, M S ...............................753*, 1829, 1972<br />
Orren, D K ............................................. 2269<br />
Orrenius, S ............................................. 2276<br />
Ortel, T L .................................................843*<br />
Ortiz-Acevedo, A .................................. 1594
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Ortiz/Bueno, A ..................................... 1619<br />
Orton, E .................................................... 915<br />
Orzech, D ........................... 1425, 1506, 2035<br />
Osborne, T ............................................... 540<br />
Osbourn, D ............................................ 1537<br />
Oshiro, W M ...................... 2089, 2090, 2092<br />
Osier, M .................................................. 1477<br />
Osimitz, T G ................................ 1075, 2160<br />
Osipov, A N ......................2282, 2283, 2284*<br />
Osna, N A .............................................. 1657<br />
Osorio, E .................................................. 427<br />
Osowski, J J ..........................................2230*<br />
Ospino, I ................................................ 1708<br />
Ostrosky, P ....................................1146, 1455<br />
Osweiler, G D ........................................ 1385<br />
Othumpangat, S ........................ 1163, 1166*<br />
Otieno, M ....................................1626, 1779*<br />
Otstot, J .................................................... 136<br />
Otsuka, M .............................................. 1379<br />
Otsuka, S .................................................. 833<br />
Otto, C M ................................................. 534<br />
Otto, M ................................................... 1057<br />
Oude Elferink, R ................................... 1051<br />
Ouyang, Y ................................................ 369<br />
Ovando, B J ................................2038, 2045*<br />
Overmann, G J ...................................... 1371<br />
Owen, M ........................................ 484, 1628<br />
Owens, S T ............................................... 504<br />
Ozaki, K ................................................... 750<br />
Ozawa, S .................................................. 709<br />
Ozeki, Y .................................................. 1703<br />
P<br />
Pabello, N .............................................. 1064<br />
Pabst Marra, T ........................................ 467<br />
Padgett, W T ......................................... 2268<br />
Padilla, A ............................................... 1708<br />
Padilla, S ............................. 966, 1277, 1939,<br />
.............................................1940*, 1941, 2095<br />
Padilla-Bank, E ..................................... 1370<br />
Padilla-Banks, E .....................................260*<br />
Padovani, A M ........................................ 688<br />
Padowski, J M ....................................... 2255<br />
Paepke, O ............................ 310, 2054, 2072<br />
Pagan, I ...................................................371*<br />
Pagan-Rodriguez, D ............................. 1386<br />
Page, J G ................................................... 797<br />
Page, T ..................................................1222*<br />
Page, T J ................................................. 1218<br />
Pagliarulo, M .............................2077, 2081*<br />
Pai, S S .................................................... 1383<br />
Paigen, K .................................................... 60<br />
Pakkenberg, B ............................. 1056, 1057<br />
Palazuelos, M ...........................................43*<br />
Palermo, C M ...........................................97*<br />
Palkar, P S ...................................73, 77, 842*<br />
Palmeira, C M ............................1835, 1849*<br />
Palmer, V S .......................1549*, 1550, 1551<br />
Pancras, J ............................................... 1451<br />
Pandey, R ................................................. 154<br />
Pang, W .................................................. 1070<br />
Pantano, P .............................................. 1594<br />
Pantle, L ................................................1891*<br />
Papagiannis, C N ............................ 170, 807<br />
Papania, M ...........................................1349*<br />
Papineni, S ............................................. 2298<br />
Papoulias, D M ....................................1289*<br />
Parchment, R E ..................................... 1776<br />
Parent, R .................................................. 635<br />
Parent-Massin, D ...................................1175<br />
Parham, A ................................................ 732<br />
Parham, F .............................................. 1376<br />
Parham, F M ............................................ 852<br />
Parikh, S ................................................... 710<br />
Paris, B L .................................................. 718<br />
Paris, M .........................................484, 1628*<br />
Park, E ...................................................... 156<br />
Park, J ......................................................156*<br />
Park, K ............................................. 156, 907<br />
Park, S ...................................111, 1215, 2041<br />
Park, Y .................................................... 1261<br />
Parker, A .................................................. 375<br />
Parker, F ................................................. 2131<br />
Parker, J .................................................. 1826<br />
Parker, J B ...............................569, 755, 1174<br />
Parkinson, A ...........................................1174<br />
Parkinson, C ............................................ 863<br />
Parkinson, C U ...................................... 1463<br />
Parkinson, H D ..................................... 1228<br />
Parng, C ....................................... 1096, 2018<br />
Parod, R ................................................... 264<br />
Parod, R J ................................................. 284<br />
Parran, D K .............................................626*<br />
Parris, C ................................................... 986<br />
Parrish, A ............................................... 2126<br />
Parton, J W .......................1203, 2189*, 2228<br />
Pasos, F ...........................................608, 1153<br />
Passaint, L ...............................................592*<br />
Pastino, G ................................... 860*, 1688*<br />
Pastoor, T ................................................671*<br />
Pastoor, T P .............................743, 744, 745*<br />
Pastusyzn, A ............................................ 724<br />
Pat, S W ........................................ 1600, 1601<br />
Patel, B B ................................................ 1493<br />
Patel, N N ...........................................70, 81*<br />
Patel, P ................................................... 1252<br />
Patel, R ................................................... 1383<br />
Pathak, S .................................................. 967<br />
Patierno, S R ...........................................1136<br />
Patino, R .................................................. 494<br />
Patlewicz, G ...........................................1196<br />
Patlolla, A K .........................................1858*<br />
Paton, S J .................................................. 791<br />
Patten, C .................................................. 710<br />
Patten, C J .............................................. 1556<br />
Patterson, R M .......................................362*<br />
Patterson, T A .............................. 1098, 1099<br />
Patton, D .................................................245*<br />
Patzer, S ................................................. 1238<br />
Paul, D S .................................................135*<br />
Paul, K .................................................... 1927<br />
Paul, S D .................................................. 419<br />
Paule, M G ....................................987*, 1072<br />
Paules, R ................................................ 1855<br />
Paules, R S ........................119, 121, 127, 757<br />
Paulsen, D ............................................. 1012<br />
Pauluhn, J .............................................1469*<br />
Paustenbach, D ........................................411<br />
Paustenbach, D J ..................257, 410*, 1338<br />
Pavco, P A .................................................15*<br />
Pavely, C ................................................ 1405<br />
Pavkov, K L ............................................. 275<br />
Pawliuk, R ............................................... 805<br />
Paximadis, P A .............................. 979, 2256<br />
Peachee, V L .....................................23, 178*<br />
Peake, J L ............................................... 1645<br />
Pearce, S ................................................. 1807<br />
Pearson, C .......................................126*, 522<br />
Pearson, E .............................................. 1072<br />
Peddada, S ................... 779, 844, 1794, 1821<br />
Peden, K ................................................. 1513<br />
Peden-Adams, M M ............................... 882<br />
Pedersen, T .............................................. 106<br />
Pederson, R ............................................1115<br />
Pedrick, N .............................................. 2180<br />
Peffer, R ............................................ 744, 745<br />
Peksa, R .................................................. 1436<br />
Pelgrim, M ................................... 1056, 1057<br />
Pelkonen, J ............................................. 1879<br />
Pelletier, D ..............................................559*<br />
Peltz, G ..................................................... 348<br />
Pence, D H ................1185, 1187, 1515, 1516<br />
Pendlington, R ...................................... 2173<br />
Penn, A ......................................... 1010, 1441<br />
penn, a ...................................................1012*<br />
Penning, T M ............................... 1043, 1815<br />
Penninks, A ............................................. 177<br />
Penninks, A H ............................... 953, 1208<br />
Penton, H ............................914, 1457, 2024*<br />
Penttinen, P ..........................................1879*<br />
Pepe, G ................................................... 1799<br />
Peraza, M A .......................................... 1911*<br />
Perdew, G .......................................657*, 715<br />
Perdew, G H ................................ 89, 90, 654<br />
Pereira, C ............................................... 1814<br />
Pereira, F E ...........................................1841*<br />
Pereira, M A .......................................... 1788<br />
Perentes, E ................................................. 61<br />
Perez, R M ............................................... 270<br />
Perez-Polo, J R ........................................ 214<br />
Perkins, R ............................................... 1704<br />
Perou, C M .............................................. 123<br />
Perrigo, E ................................................. 849<br />
Perrigo, E E ...........................................1306*<br />
238<br />
Persaud, J ................................................1139<br />
Person, M ................................................2118<br />
Person, M D ........................................... 1801<br />
Perstin, J ................................................2250*<br />
Perumean-Chaney, S ............................ 1009<br />
Pescovitz, O H ........................................ 255<br />
Pessah, I ................................................. 2060<br />
Pessah, I N ....................................... 46, 2053<br />
Peters, J M ......................... 55, 583, 586, 587,<br />
.........................................588, 759, 1820, 1911<br />
Peters, L ................................................2059*<br />
Petersen, D D .........................................250*<br />
Petersen, D R ..............185, 209*, 1718, 1723<br />
Petersen, S L .......................................... 2036<br />
Peterson, B ............................................1720*<br />
Peterson, J H ......................................... 1100*<br />
Peterson, M K ................................248, 871*<br />
Peterson, R .............................................. 905<br />
Peterson, R E ................ 87, 88, 91, 130, 548,<br />
................................ 550, 554, 555, 1824, 1825<br />
Peterson, W M ........................................ 465<br />
Petranka, J ....................................... 828, 829<br />
Petrella, D K .................................... 80, 1932<br />
Petrick, J S .................143, 1762, 1763*, 2140<br />
Petrov, A ................................................. 1058<br />
Petsikas, D ............................................... 737<br />
Pettan-Brewer, C ....................................968*<br />
Pettersson, I ............................................. 679<br />
Pettersson, S .......................................... 1358<br />
Petty, R ....................................................1195<br />
Pezzoli, P ................................................. 754<br />
Pfau, J C .......................................... 686, 911*<br />
Pfeifer, K F ............................................. 2152<br />
Pham, C ................................................... 790<br />
Phelps, R L ................................................... 6<br />
Philbert, M A ............. 979, 1535, 1536, 1882<br />
Philip, B K .........................................73*, 842<br />
Phillips, C S ....................................125*, 774<br />
Phillips, J ................................................ 2013<br />
Phillips, P ............................................... 1940<br />
Phillips, P M ...................... 1078, 1091, 1941<br />
Phillips, T D ....................... 524, 1283, 1309,<br />
.............................................1400, 1402, 2270*<br />
Pi, J ...........................................................817*<br />
Picano, P L ............................................. 1556<br />
Piccotti, J R ................................... 180*, 1195<br />
Piechta, L ................................................. 755<br />
Pieper, R ................................. 64, 1005, 1900<br />
Pierce, J S ............................................... 1938<br />
Pierce, J T ................................................. 919<br />
Pierce, R ................................................... 225<br />
Piersma, A ................................... 1490, 1734<br />
Piersma, A H ......................................... 2061<br />
Pietenpol, J ............................................ 1810<br />
Pieters, R .............................903*, 1205, 1892<br />
Pine, P S ..................................................121*<br />
Pinkerton, K E ...................... 504, 927, 1008,<br />
........................................... 1014*, 1221, 1645*<br />
Pinn, L .................................................... 2261<br />
Pino, M ....................................114, 915, 1464<br />
Pinon-Zarate, G .............................608, 1153<br />
Pinsonneault, L ....................262, 558*, 1462<br />
Pitot, H C ................................................667*<br />
Pitot, III, H ............................................... 671<br />
Pittinger, C ............................................... 375<br />
Pittman, G S .............................................115<br />
Pitts, D K .........................................601*, 602<br />
Pizarro, K ............................................... 1070<br />
Plamondon, P ...............................1127, 1128<br />
Plant, N .................................................... 580<br />
Plante, I .........................................764*, 1651<br />
Plat<strong>of</strong>f, G E ...................................... 795, 796<br />
Pleus, R C .............................. 248, 871, 2102<br />
Plewa, M .................................................. 408<br />
Plitnik, L M ............................................ 1715<br />
Plopper, C .............................................. 1891<br />
Plopper, C G .................359, 916, 917, 1016*<br />
Plotzke, K ................................................ 949<br />
Plotzke, K P .......................... 848, 855, 1237,<br />
...............1507*, 1508, 1509, 1510, 1751, 1812<br />
Plummer, S ................................. 761*, 2258*<br />
Pluta, L ......................................... 1218, 1222<br />
Poellinger, L .......................................... 1358<br />
Poet, T .....................................................233*<br />
Poet, T S ................................................. 1336<br />
Pognan, F ............................. 508, 1626, 1779<br />
Pohjanvirta, R ....................................... 2042<br />
Pohl, H ..................................................... 390<br />
Pohl, L R .................................................. 905<br />
Polisini, J M ........................................... 2079<br />
Polk, W W .....................................184*, 1216<br />
Pollard, D L ........................................... 2174<br />
Pollenz, R S ......86, 100, 1357*, 1654*, 1658*<br />
Pomeroy-Black, M .................................. 315<br />
Pomeroy-Black, M J ............................1944*<br />
Pomper, M G ..........................................676*<br />
Ponce, R ................................................... 800<br />
Pons, C ................................................... 1732<br />
Ponten, E ................................................ 1073<br />
Poole, C A ................................................ 254<br />
Poole, T J .................................................. 686<br />
Pooler, M .............................204*, 1445, 1964<br />
Pooler, M S ............................................ 1369<br />
Popat, J ......................................... 1357, 1658<br />
Pope, C ....................................................... 51<br />
Pope, C N ...............................................998*<br />
Popovic, M .............................................904*<br />
Popp, J ...................................................... 670<br />
Portas, M ................................................ 1865<br />
Porter, D ................................................... 933<br />
Porter, D W ............................................ 1443<br />
Porter, K ..................................................541*<br />
Portier, C J ..................... 33, 852, 1302, 1376<br />
Portier, K M ........................................... 2074<br />
Portsmouth, C ....................................... 1710<br />
Possolo, A .............................. 93, 2044, 2056<br />
Post, J ...................................................... 2120<br />
Postlethwait, E ............................................ 2<br />
Potapovich, A I ....................................2282*<br />
Potapovich, M V ......................... 2283, 2284<br />
Potnis, P A ..............................................381*<br />
Pottenger, L H ......................................1041*<br />
Potter, L K .............................................. 1296<br />
Potter, P M ............................................. 1569<br />
Potti, A ..................................................... 843<br />
Potts, R ..................................................1516*<br />
Pouliot, L ..............................262*, 558, 1462<br />
Pounds, J G ............................. 108, 122, 918,<br />
................................................ 919, 1551, 1705<br />
Pouyatos, B ................................................ 50<br />
Powell, C L ...........................................1855*<br />
Powell, E .................................................1160<br />
Powell, J L .................................... 1262, 1451<br />
Powell, K ................................................. 527<br />
Powell, P ................................................ 1642<br />
Power, F W ...................................870, 1298*<br />
Powers, B E ..........................................1085*<br />
Powers, K .................................................. 43<br />
Powley, M W ..................................198*, 525<br />
Powrie, R ......................................... 277, 733<br />
Prabhakaran, K ........................... 1543, 2279<br />
Prabu, S K ................................................ 205<br />
Prasch, A L ..........................................88*, 91<br />
Prater, M R ............................................2261*<br />
Prater, R ................................................... 685<br />
Pratt, A ................................................... 2021<br />
Pregenzer, J F .................................80*, 1932<br />
Presley, S M ........................................... 2016<br />
Preuss, H G ........................................... 1414<br />
Price, B B .................................................1197<br />
Price, J .................................................... 1810<br />
Price, K ....................................................349*<br />
Price, O ....................................................2110<br />
Price, R J ................................................. 2160<br />
Price, V ......................................... 1637, 1642<br />
Price, W A ................................................ 789<br />
Prince, V L ............................................2000*<br />
Pringle, H .............................................. 1276<br />
Pritsos, C A ....................... 958, 1008*, 1009*<br />
Pritsos, K L ............................................ 1009<br />
Privalle, L ............................................... 1307<br />
Proctor, D ...................................... 382*, 421*<br />
Prohaska, J R ........................................... 279<br />
Prophete, C ...........................................1453*<br />
Proscura, E .............................................. 784<br />
Prough, R ............................................... 1844<br />
Provost, J .................................................. 830<br />
Prozialeck, W C ............1602*, 1605*, 2129*<br />
Prucha, M ................................................ 575<br />
Pruett, S B .......896*, 897, 898, 899, 900, 901<br />
Pruimboom-Brees, I ............................... 490<br />
Pu, X ......................................................... 760<br />
Puga, A ............... 92, 99, 103, 104, 132, 2267<br />
Pulido, M ..............................................2126*<br />
Pung, T ..................................................1943*<br />
Puppala, D ................................................85*<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Purdom, S E .........................................1848*<br />
Purdy, R ................................................. 1210<br />
Putt, D A .....................................1905, 2127*<br />
Puzas, E .................................................. 1031<br />
Puzas, J E .................................... 695*, 1034*<br />
Pyatskowit, J ..........................................279*<br />
Pyatt, D ........................................... 258*, 411<br />
Pyo, M ...................................................... 256<br />
Q<br />
Qadri, I ..................................................... 713<br />
Qian, X ............................................... 58, 136<br />
Qian, Y ................................614*, 2132, 2270<br />
Qiao, D ....................................................964*<br />
Qiao, G ................................................... 1694<br />
Qiao, G G .................................. 1690*, 1692*<br />
Qu, W ....................................136, 748, 1608*<br />
Quackenbush, J ....................................1980*<br />
Quall, C W ............................................... 905<br />
Quan, C ...................................................697*<br />
Quattrochi, L C ....................................... 713<br />
Quinn, A L ............................................1751*<br />
Quinn, C P ............................................... 772<br />
Quintana, M .......................................... 1865<br />
Quintanilla-Vega, B ...............................1147<br />
Quintas, P E ............................................. 520<br />
Quynh, H T ........................................... 2072<br />
R<br />
Raabe, H .............................. 484, 1628, 2001<br />
Raabe, H A ............................................1630*<br />
Rabemampianina, Y ............................... 830<br />
Rachman, N J .......................................... 653<br />
Racz, W J .................................................. 935<br />
Raczynski, A .................................. 464, 1632<br />
Radcliffe, P M .......................................1530*<br />
Radic, Z .................................................... 997<br />
Raemisch, A ........................................... 1461<br />
Raffaele, K ..............................................977*<br />
Raffaele, K C ........................................... 380<br />
Raghavan, N ........................................... 755<br />
Rahman, A A ........................................... 961<br />
Rajanna, B .............................................. 1065<br />
Rajendran, N ..............923, 1186, 1235, 1517<br />
Rall, M J ................................................. 1665<br />
Ralston, R ................................................ 798<br />
Ramadoss, P ............................................ 657<br />
Ramaiah, S K ......................................... 1047<br />
Ramapuram, J ......................................2190*<br />
Ramasubramanian, B ........................... 1922<br />
Ramesh, A ...................................1497*, 1498<br />
Ramirez, P ..............................................139*<br />
Ramirez-Alcantara, V ...........................498*<br />
Ramirez-Garcia, X S ............................1412*<br />
Ramos, K S .........................614, 1983*, 2132<br />
Ramos, Z ................................................ 2219<br />
Rampersand, C R ................................... 473<br />
Ramsdell, J S ......................................... 1070<br />
Randine, G ................................... 1055, 2051<br />
Rane, M .................................................. 1226<br />
Ranken, P F ..........................................1597*<br />
Rankin, G O ......................2121*, 2122, 2123<br />
Rannug, A .............................................1358*<br />
Rao, G ....................................................1874*<br />
Rao, G K ................................................... 369<br />
Rao, P S ................................................... 114*<br />
Rappaport, S M ..................................... 1301<br />
Rasco, J F ................................................ 1067<br />
Rath, M .................................................. 1494<br />
Rauen, U ................................................ 1818<br />
Rauma, M .............................................2198*<br />
Rausch, L ............................................... 1095<br />
Ravel, G ................................................... 885<br />
Ravoori, S .............................................. 1799<br />
Ray, R ....................................................... 724<br />
Ray, S D .......................................1410, 2301*<br />
Raymond, C ............................................ 287<br />
Raymond, E ............................................1107<br />
Raynal, N ............................................... 1651<br />
Raynal, N J ...........................................1790*<br />
Raynard, A ............................................. 1240<br />
Rayner, J L .................................... 299, 1122*<br />
Raza, H ....................................................205*<br />
Razani-Boroujerdi, S ................................ 21<br />
Razdolsky, A N ..................................... 1936<br />
Read, D E ............................................... 1967<br />
Reams, R .................................................. 615<br />
Reaney, S .................................................. 630<br />
Reardon, K F ..........................................865*<br />
Rebelatto, M ............................................ 170<br />
Reckwitz, T ............................................ 1269<br />
Reddy, G ...............................................1238*<br />
Reddy, J K .................................................. 77<br />
Reddy, M ............................................... 1246<br />
Reddy, M B .....................................848*, 855<br />
Reddy, R ................................................. 1882<br />
Reddy, R N ...........................................2138*<br />
Reddy, V .................................................... 13<br />
Reece, J ..................................................... 817<br />
Reece, M T ............................................. 1281<br />
Reed, D A ............................................... 2078<br />
Reed, J R ..........................................725, 740*<br />
Reed, K ............................................703, 704*<br />
Reed, M ............................... 455, 460*, 1345*<br />
Reed, S ................................................... 2021<br />
Reeder, M K .......................................... 2011*<br />
Regal, J F ...............................................1717*<br />
Regal, R R .............................................. 1717<br />
Regan, J M ............................................. 1751<br />
Regan, K S ............................................. 1510<br />
Regenass, F ...........................................1878*<br />
Regnier, F E ............................................. 501<br />
Regunathan, A ...................................... 1035<br />
Reichard, J F ...........................................132*<br />
Reid, A B .................................................224*<br />
Reid, K R .................................................. 737<br />
Reilly, C A ...................................... 937, 1219<br />
Reily, M D .........................................511, 530<br />
Reimers, M ...........................................2243*<br />
Reiners, J J ...............................................995*<br />
Reisfeld, B .................................... 1300, 1306<br />
Reliene, R ............................208, 2232, 2272*<br />
Remon, J ................................................. 2015<br />
Ren, H .....................2143, 2148, 2150*, 2151<br />
Ren, S ............................................. 806, 2083<br />
Renne, R A ....................................... 506, 919<br />
Renner, J ........................................... 776, 787<br />
Renner, K ............................................... 2303<br />
Rentz, S S ................................................. 797<br />
Reo, N V ................................................... 526<br />
Repnevskaya, M ................................... 2233<br />
Resau, R ..................................................317*<br />
Retief, J ......................................... 1819, 2150<br />
Retief, J D ................................................. 121<br />
Rettenmeier, A W ........................ 1818, 2225<br />
Reuhl, K ................................................. 1058<br />
Reuhl, K R .................... 610, 611, 983, 1662*<br />
Reutter, S A .............................................. 794<br />
Reyes, J L ................................................1132<br />
Reyes-Olivera, A ..................................... 608<br />
Reynolds, J D .......................................... 359<br />
Reynolds, T ................................. 1404, 1671<br />
Rhee, G ..................................................1635*<br />
Rhomberg, L ...........................................386*<br />
Rhomberg, L R ........................................ 384<br />
Rhule, A ................................................1420*<br />
Rice, E ..................................................... 1671<br />
Rice, J M ................................................... 669<br />
Richard, A M ........................................1024*<br />
Richard, B M ................................718, 1935*<br />
Richards, J H ................................... 441, 927<br />
Richardson, J R ...........................973*, 1097,<br />
.............................................. 1529, 1545, 1961<br />
Richardson, R J .............................. 192, 824,<br />
.................................... 1843, 1936, 1937, 1938<br />
Richardson, T .........................................722*<br />
Richardson, V M ........................1227, 1769*<br />
Richburg, J H ......................................... 2292<br />
Richfeild, E .............................................. 645<br />
Richfield, E K ........................................ 1958<br />
Richter, A ..............................................2013*<br />
Richter, R ................................................. 409<br />
Richter, R O ............................................. 412<br />
Richter, W R ...................................770*, 771<br />
Rick, D ............................................ 269, 1563<br />
Ricks, R ...................................................1139<br />
Rideaux, C B .........................................1852*<br />
Riehl, J ...................................................2060*<br />
Riffle, J ...................................................... 486<br />
Riley, D J .................................................. 780<br />
Riley, R T ...........................1391*, 1395, 1396<br />
Rinderknecht, A ...................................1066*<br />
Ringeissen, S A ........................................ 491<br />
up-to-date information at www.toxicology.org 239<br />
Ringham, H ........................................... 2180<br />
Rintala, E ................................................749*<br />
Riordan, W .............................................. 464<br />
Rios, F ......................................................1146<br />
Rioux, K ................................................... 181<br />
Ripp, S L .................................................357*<br />
Ripper, T L ..............................................2011<br />
Ripple, S D ............................................. 1480<br />
Rise, M ................................................... 2238<br />
Ritov, V B ........................... 2284, 2294, 2295<br />
Ritz, S A .................................................... 458<br />
Riviere, J ................................................. 2180<br />
Riviere, J E .................................. 2175, 2176,<br />
.........................2183, 2184, 2194, 2196, 2197*<br />
Roach, F ................................................. 2080<br />
Robb, A .................................................. 1095<br />
Robert, D .................................................. 437<br />
Roberts, A E .................................. 560*, 577*<br />
Roberts, D W ........................................2185*<br />
Roberts, E .............................................. 1444<br />
Roberts, E S ............................................940*<br />
Roberts, J R ...................................939, 1449*<br />
Roberts, R ................................. 1649*, 1650*<br />
Roberts, R A ....................................118, 2131<br />
Roberts, S M ......................... 696, 909, 2073,<br />
........................................................ 2074, 2186<br />
Robertson, D G ................................511, 530<br />
Robertson, J L ........................................ 1816<br />
Robertson, L .......................................... 2054<br />
Robertson, L W ....... 1082, 1487, 1488, 2058<br />
Robertson, S A ......................................... 772<br />
Robinson, J ............................................ 1655<br />
Robinson, J F .............................. 1155, 2257*<br />
Robinson, K ....................262, 411, 558, 1462<br />
Robinson, M ............................................ 744<br />
Robinson, P ..........................785, 1172, 1178<br />
Robinson, P J ................................786*, 1305<br />
Robinson, S D .......................................... 437<br />
Robison, C ....................................... 776, 787<br />
Robison, S H .........................................1291*<br />
Robosky, L C ........................................... 530<br />
Rockett, J ................................................ 2145<br />
Rockett, J C ...............188, 2143, 2148, 2151*<br />
Rockwell, C E .......................................... 369<br />
Rockwood, G A ............................... 795, 796<br />
Rodgers, P ............................................... 768<br />
Rodriguez, C ........................................... 461<br />
Rodriguez, E ......................................... 2303<br />
Rodriguez, G ........................................... 253<br />
Rodriguez, V M ...................................1957*<br />
Rodriguez-Fernandez, I ...................... 1893<br />
Rodriguez-Lara, V .........................608, 1153<br />
Roemer, H .............................................. 1269<br />
Roesch, S .................................................. 492<br />
Roger, V ................................................. 2032<br />
Rogers, B A ............................................ 1024<br />
Rogers, C ................................................. 805<br />
Rogers, E ................................................ 2248<br />
Rogers, J M .....................3, 280, 1643*, 2255<br />
Rogers, J V ....................................... 770, 771<br />
Rogers, L K .................................1726*, 1854<br />
Rogers, R E .............................................1190<br />
Rogers, R L ............................................ 1758<br />
Rogers, T L .............................................1176<br />
Rogers, W J .............................................. 106<br />
Rogge, M ................................................. 800<br />
Roh, S ....................................................1409*<br />
Rohde, C A ............................................ 1542<br />
Rohr, A C ........................................438, 439*<br />
Rojas, M ................................................. 1840<br />
Rojas-Lemus, M .............................608, 1153<br />
Rolfe, M ................................................... 464<br />
Rollins-Hairston, A M .......................... 1570<br />
Rolo, A .....................................................827*<br />
Rolo, A P ................................................ 1849<br />
Romach, B H ........................................... 584<br />
Roman, R ............................................... 1897<br />
Roman Gomez, R ..................................979*<br />
Ronis, M J ............................... 74, 274, 1031,<br />
...................................1036*, 1737, 1918, 1919<br />
Ronquillo, D ............................................ 252<br />
Roomi, M ..............................................1494*<br />
Roop, B ......................................... 2144, 2146<br />
Roponen, M ..........................................1880*<br />
Rosado, J L ............................................... 252<br />
Rosales, G ................................................ 253<br />
Rosales-Garcia, V ..................................1147<br />
Rosdy, M .................................................. 482<br />
Rose, M .................................................... 681<br />
Rose, P ...................................................... 745<br />
Rose, R L .......................................... 358, 726<br />
Rosenfeld, C ............................................ 860<br />
Rosenfeld, C A .....................................2154*<br />
Rosengren, R J ............................... 707, 1489<br />
Rosenstein, M ........................................ 1706<br />
Rosenthal, A F ......................................... 629<br />
Rosenthal, G ............................................ 766<br />
Rosenzweig, B A ..................................... 121<br />
Rosier, R ................................................... 695<br />
Rosini, G P ..............................................1137<br />
Ross, D ............................................. 47, 2276<br />
Ross, D G ............................................... 1227<br />
Ross, J A ................................................2268*<br />
Ross, J S .................................................... 976<br />
Ross, M K ..............................................1569*<br />
Ross, P .................................................... 1855<br />
Ross, S M ................................................. 276<br />
Rossi, B ................................................... 1732<br />
Rossman, T G .......................................1045*<br />
Rosson, G ............................................... 1791<br />
Roszell, L E .............................................164*<br />
Roth, M D ................................................ 926<br />
Roth, R A ................................ 69, 1930, 2052<br />
Rothenberg, J C ....................................... 429<br />
Rothenberg, S J ......................................429*<br />
Rothman, N ........................................... 1301<br />
Rotman, R .............................................. 1383<br />
Rottinghaus, G ...................................... 1385<br />
Rottman, J .............................................. 1632<br />
Roubicek, D A ....................................... 1455<br />
Rouleau, M ...................................1127, 1128<br />
Rouleau, N .....................................174, 195*<br />
Round, D P ............................................ 1945<br />
Rouquie, D .................................. 1731, 1732<br />
Rowan, W H ............................................ 433<br />
Rowden, J .............................................. 2071<br />
Rowe, A M ............................................1886*<br />
Rowland, T ...................................... 776, 787<br />
Rowton, S ...........1106*, 1172*, 1178*, 2200*<br />
Roy, C J ..................................................1470*<br />
Roy, D ..................................................... 1774<br />
Roy, N ....................................................1096*<br />
Roy, S K .......................................1927*, 2215<br />
Royland, J .............................................. 1445<br />
Royland, J E ................................1081, 1964*<br />
Royster, S ................................................. 795<br />
Rozman, K K ..................... 2034, 2048, 2050<br />
Ruan, Q .................................................1043*<br />
Rubin, E M .............................................1129<br />
Rubio-Andrade, M ......................... 252, 253<br />
Rubitski, E E ...............................2230, 2233*<br />
Ruble, K M ............................................ 1504<br />
Ruby, M V .............................................. 2084<br />
Ruchirawat, S ........................................ 1747<br />
Rudge Jr., T L .......................................... 780<br />
Ruf, S ........................................................ 924<br />
Rumbeiha, W K .....................................534*<br />
Runge-Morris, M .................................1976*<br />
Runge-Morris, M A .............................. 1974<br />
Runkle, S A ...........................................1535*<br />
Runnion, V .............................................. 419<br />
Rusch, G ................................................. 1485<br />
Russek, N ................................................1107<br />
Russel, L T ..............................................632*<br />
Russell, J .....................................2098, 2103*<br />
Russo, M .................................................. 497<br />
Rusyn, I .........................60, 759, 1046*, 1855<br />
Rutherford, M ....................................... 1717<br />
Rutkiewicz, J M ...................................... 888<br />
Ryan, C .................................................. 1196*<br />
Ryan, C A ............................1198, 1201, 1999<br />
Ryan, J ...................................................... 310<br />
Ryan, M ...............................1181, 2035, 2070<br />
Ryan, M J ............................................... 1425<br />
Ryan, T P .....................................1968, 1971*<br />
Ryter, S W .............................................. 2284<br />
Ryu, H .................................. 992, 1870, 2288<br />
S<br />
Saad, A ................................................... 1626<br />
Sabnis, A S ..............................................937*<br />
Sabo-Attwood, T .................................. 1773<br />
Sabourin, C L .................. 770, 771, 774, 780<br />
Sabri, M I ..........................1549, 1550, 1551*
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Sachana, M ...........................................1950*<br />
Sadler, C ..................................................1511<br />
Sadovova, N .......................................... 2285<br />
Safe, S .......................................... 1368, 1764,<br />
.................................... 1770, 1807, 1808, 2298<br />
Safe, S H ..................................................993*<br />
Safford, B ............................................... 1201<br />
Safford, R J ............................................. 1293<br />
Sagelsdorff, P .........................................219*<br />
Saghir, S A ................................... 1176, 1242*<br />
Sahoo, R ................................................. 1876<br />
Said, M M .............................................. 1424<br />
Saigo, K .................................................. 1399<br />
Saito, F .................................................... 1379<br />
Saito, K ........................................... 750, 1379<br />
Saito, N ........................................ 2064, 2068<br />
Saito, Y ................................................... 1399<br />
Sakaguchi, H .................... 1192, 1193*, 1194<br />
Sakai, S ....................................................945*<br />
Sakai, Y .................................................... 485<br />
Salgado, V L ................................ 1962, 1963<br />
Salinas, K A ........................................... 1598<br />
Salinas-Carmona, M ............................ 1412<br />
Salinas-Moreno, J E ................................ 567<br />
Salmen, R ................................................. 705<br />
Salmon, A .............................................. 2109<br />
Salmon, A G ........... 1476, 1519*, 1521, 2111<br />
Salnikow, K ..................................641*, 1453<br />
Salonen, R O ........................ 436, 1446, 1895<br />
Samaniego, A .......................................... 766<br />
Sambuco, C P ........................................ 2193<br />
Samet, J .................................................... 428<br />
Samet, J M .............................................. 1450<br />
Sammons, D L ......................................... 772<br />
Samokyszyn, V ..................................... 2217<br />
Sampey, B P ............................................185*<br />
Sampo, B ................................................ 1550<br />
Samsam, T E .....................2089, 2090*, 2092<br />
Samson, M ................................... 1731, 1732<br />
Samuelsen, M .................................450, 453*<br />
Samura, K ................................................ 176<br />
Sanborn, J R ........................................... 2152<br />
Sanchez, J ................................................. 629<br />
Sanchez-Pena, L C .................................. 603<br />
Sand, S .....................................................405*<br />
Sanders, J M ................................. 116*, 1230<br />
Sanders, R A .......................................... 1401<br />
Sanderson, J ........................................... 1734<br />
Sanderson, J T ....................................... 2059<br />
Sanderson, T ......................513, 1747*, 1748<br />
Sanderson, T P ...................................... 1781<br />
Sandler, D P ........................................... 1333<br />
Sandstrom, T ................................. 307, 1446<br />
Sandwick, S J ..........................................1145<br />
Sandy, M S ....................................396*, 1521<br />
Sangaiah, R ............................................ 1847<br />
Sanner, T .................................................385*<br />
Sano, M .................................................... 742<br />
Santamaria, A B .....................................653*<br />
Santella, R M ........................................ 1011*<br />
Santhanam, P .......................................... 449<br />
Santiago, M R .......................................2219*<br />
Santiago, P ............................................... 242<br />
Santory, J .................................................. 373<br />
Santostefano, M J ...................................491*<br />
Santra, S ................................................. 2186<br />
Saoo, K ................................................... 1471<br />
Sarafian, T A ...........................................926*<br />
Saranko, C J ......................2074, 2075*, 2076<br />
Saranko, C M ........................................ 2073<br />
Sarisky, J ................................................... 425<br />
Sartor, M .................................................. 103<br />
Sasaki, M .......................................... 176, 980<br />
Sasaki, S ................................................... 423<br />
Sasaki, Y ................................................. 1388<br />
Sasaki, Y F .............................................. 2213<br />
Sasser, L B ................................................ 238<br />
Sasseville, V ................................. 1632, 2027<br />
Sasseville, V G .......................................464*<br />
Sato, H ...................................604, 816, 1703*<br />
Sato, I ............................................ 1954, 1966<br />
Sato, K .................................................... 1501<br />
Sato, M ..........................................226*, 1615<br />
Sato, T .................................................... 2213<br />
Satoh, H ................................................... 812<br />
Satoh, M ............ 605, 1152, 1191, 1318, 1611<br />
Satoh, T ............................................ 459, 944<br />
Satoshi, T ............................................... 1640<br />
Saulsbury, M D ..................................... 1945<br />
Saunders, G ............................................. 887<br />
Saunders, K R ....................................... 2121<br />
Saunders, M D .......................................528*<br />
Savateeva, T N ........................................ 468<br />
Savolainen, K ........................................ 1885<br />
Sawada, M ....................................... 605, 700<br />
Sawant, S P .....................................62, 1910*<br />
Saxtorph, H ........................................... 2028<br />
Sayer, A N .............................................. 2227<br />
Sayes, C .................................................... 703<br />
Sayes, C M ..................................1862*, 2185<br />
Scabilloni, J .............................................. 702<br />
Scallet, A ................................................ 2285<br />
Scandlyn, M J .........................................707*<br />
Scaramell, H .......................................... 1833<br />
Scaramella, P ............................................411<br />
Schadt, E .................................................. 287<br />
Schaefer, G ............................................... 978<br />
Schaefer, G J ............................................ 473<br />
Schaeffer, D J ........................................... 545<br />
Schafer, R ............................................... 1886<br />
Schantz, S L ........................................... 1085<br />
Schatz, R A ............................................... 943<br />
Schauer, U .............................................. 1239<br />
Schebler, P ............................................2069*<br />
Schechtman, L M .................................1355*<br />
Schecter, A J ........................ 309, 310*, 2072*<br />
Scheffer, G .............................................. 1921<br />
Schehl, T L ............................................... 491<br />
Schettler, S ............................................1071*<br />
Scheuplein, R ........................................ 1343<br />
Schiestl, R ...............................................335*<br />
Schiestl, R H ...................... 208*, 333*, 2230,<br />
.............................................. 2232, 2233, 2272<br />
Schilling, B ............................................. 2054<br />
Schilling, B E ......................................... 1781<br />
Schilling, C .............................................422*<br />
Schisler, M R .......................................... 1041<br />
Schladweiler, M C .........................441, 927*<br />
Schladweiler, M J .................................... 433<br />
Schlager, J .............................................. 1625<br />
Schlager, J J ...........................................2174*<br />
Schlager, J M .......................................... 1719<br />
Schleef, R ................................................. 924<br />
Schlenk, D ............................ 739, 1555, 1590<br />
Schlesinger, R B .......................................... 2<br />
Schlezinger, J ................................367*, 1869<br />
Schlezinger, J J ........... 992, 1870, 1871, 2288<br />
Schlosser, P M ......................................1467*<br />
Schlueter, K ............................................. 924<br />
Schmid, J ................................................ 1709<br />
Schmid, J E ........................... 188, 683, 2143,<br />
.............................................. 2148, 2150, 2151<br />
Schmidt, C M ........................................ 1621<br />
Schmidt, T ............................................. 1269<br />
Schmitz, H ............................................. 2054<br />
Schmued, L ............................................ 2285<br />
Schnaas, L ................................................ 427<br />
Schnackenberg, L K ....................... 509*, 511<br />
Schneider, J C ........................................ 1841<br />
Schneider, M C ...................................... 1841<br />
Schneider, R J .......................................1882*<br />
Schneider, S N ..............................227, 1599*<br />
Schnellmann, R G ............. 2125, 2128, 2130<br />
Schoen, A ..............................................2085*<br />
Scholten, D ............................................ 1747<br />
Scholz, N ................................................ 1584<br />
Schomaker, S ........................................... 490<br />
Schomaker, S J ........................................716*<br />
Schon, J .................................................... 982<br />
Scho<strong>of</strong>, R A ............................................ 2084<br />
Schramm, K ........................................... 2050<br />
Schramm, U ........................................... 1863<br />
Schrenk, D ................................... 2054, 2061<br />
Schuessler, T F ......................................... 920<br />
Schuetz, E G .....................................65, 289*<br />
Schuh, R A ............................................1960*<br />
Schuler, M J ............................................. 337<br />
Schultz, I ................................... 1586*, 2021*<br />
Schultz, P G ........................................... 1721<br />
Schulze, J B .................................... 397, 1403<br />
Schulze, M M ........................................ 1403<br />
Schumann, B ......................................... 2267<br />
Schut, M ................................................. 1560<br />
Schwab, C L ............................896, 897*, 900<br />
Schwaber, J S ........................................1981*<br />
Schwaiger, S .......................................... 2303<br />
240<br />
Schwartz, A J ........................................... 462<br />
Schwartz, B S ...................... 430, 1148, 1327*<br />
Schwartz, D A ............................... 928, 1846<br />
Schwartz, L W ............................... 536, 1828<br />
Schwartz, R H ....................................... 1872<br />
Schwarz, E ............................................... 695<br />
Schwarz, M ............................................ 2054<br />
Schwarze, P E .......................................... 417<br />
Schwegler-Berry, D ..................... 1468, 2282<br />
Schweikart, K .......................................... 801<br />
Schwengberg, S ....................................1996*<br />
Schwetz, B A .........................................1681*<br />
Sciarrotta, J .............................................. 905<br />
Scicchitano, M S .................................... 1828<br />
Sciullo, E M ........................................... 1442<br />
Scollon, E J ....................................850, 1250*<br />
Scott, P ..............................................257, 411<br />
Scotto, J .................................... 776, 787, 793<br />
Scotto, J A ......................................... 775, 788<br />
Scrafford, C G ......................................... 693<br />
Seacat, A ................................................. 1236<br />
Seagrave, J ........ 2, 2, 455, 456*, 1015, 1017*<br />
Seaman, C .............................................. 2009<br />
Seaman, C W ................................372, 2006*<br />
Secrest, J T ............................................... 808<br />
Seegal, R F ..........................621, 1083, 1988*<br />
Seeley, M ...............................................2083*<br />
Seeley, M R ............................................ 1071<br />
Seeram, N ................................................ 926<br />
Segarra, A ...............................................624*<br />
Segura, B .................................................. 603<br />
Sehata, S ................................................1433*<br />
Sehgal, I ................................................... 932<br />
Seid, D A ....................................... 379, 1179*<br />
Seidel, T ................................................. 1269<br />
Seidler, F J .................... 964, 965, 1068, 1069<br />
Seki, T ..................................... 980, 981, 1730<br />
Sekijima, M .................................... 763, 1379<br />
Seko, Y .....................................................1152<br />
Sekowski, J W ........................................793*<br />
Selby-Mohamadu, Y ............................ 2100<br />
Selevan, S G ..................................... 255, 378<br />
Selgrade, M ............................ 18*, 19*, 1213<br />
Selgrade, M K ....................................... 1715<br />
Selim, S ..................................................2107*<br />
Selinski, S ............................................... 1269<br />
Sellers, T S ............................................... 536<br />
Sells, D M ............................................... 1506<br />
Semano, M ............................................. 1864<br />
Sen, B ...................................371, 1816, 1819*<br />
Sen, C ..................................................... 1393<br />
Sen, U ....................................................... 691<br />
Senese, P .................................................. 839<br />
Seng, J ........................................... 1637, 1642<br />
Seng, J E ..................................................706*<br />
Sens, D A ............................... 146, 147, 1606,<br />
.............................................1614, 1616*, 1618<br />
Sens, M ....................1606, 1614, 1616, 1618*<br />
Sentissi, J ...................................................911<br />
Seo, M .................................................... 1191*<br />
Seo, M J .................................................... 202<br />
Seok, J ..................................................... 1635<br />
Serle, J .................................................... 1288<br />
Serrano, J ..............................................1755*<br />
Sette, W .................................................... 977<br />
Setzer, W ................................................ 1939<br />
Sexton, K .................................................. 930<br />
Sexton, K G .............................................. 942<br />
Sey, Y ...................................................... 2145<br />
Shabat, S .................................................. 844<br />
Shafer, T J ....................49, 1547, 1548*, 1953<br />
Shah, I .....................................................537*<br />
Shah, N .................................................. 1410<br />
Shaikh, Z A ............................................ 1607<br />
Shakarjian, M P ............................. 780, 2171<br />
Shan, W ......................................... 583*, 1911<br />
Shankar, K ....................74, 274*, 1036, 1737<br />
Shanker, G ............................................... 620<br />
Shansab, M ............................................ 1871<br />
Shara, M ................................................1414*<br />
Sharlin, D ..............................................1086*<br />
Sharma, N .............................................1389*<br />
Sharma, R P ........................... 76, 1389, 1434<br />
Sharpe, R ................................................ 2258<br />
Sharrett, E ................................................ 430<br />
Sharrett, R ................................................ 430<br />
Shatkin, J ................................................ 2100<br />
Shaver-Walker, P ...................................840*<br />
Shaw, D .................................................1209*<br />
Sheabar, F .............................................. 1634<br />
Shearer, J ......................................... 810, 811*<br />
Sheasgreen, J E ............................1171, 1254,<br />
.............................................. 2002, 2003, 2191<br />
Shedl<strong>of</strong>sky, S I ........................................727*<br />
Sheehan, P ............................................... 409<br />
Sheen, Y Y ..................................... 202*, 720*<br />
Shelby, M K ..........................................1761*<br />
Sheldon, L .............................................. 1291<br />
Shelley, J T ............................................... 159<br />
Shen, A ..................................................... 490<br />
Shen, D ..................................................... 227<br />
Shen, J ....................... 144*, 1264, 1801, 2118<br />
Shen, M .................................................. 1301<br />
Sheng, L ................................................. 1513<br />
Sheng, T ................................................... 721<br />
Shenton, J M ............................................ 904<br />
Shepherd, D M .............................. 364, 1420<br />
Shepherd, N ................................ 1465, 1466<br />
Sherchan, J ............................................. 2263<br />
Sherr, D .......................................... 367, 1869<br />
Sherr, D H ....................................990*, 1359,<br />
.............................................1870*, 1871, 2288<br />
Shertzer, H G ........................................... 227<br />
Sheth, C M ............................................... 178<br />
Sheu, T ..................................................... 695<br />
Shi, D .....................................................1555*<br />
Shi, L ............ 1098, 1099, 1381*, 1624*, 1704<br />
Shi, S ........................................................579*<br />
Shibanushi, T ........................................ 1640<br />
Shibata, E ............................................... 1248<br />
Shields, W J ........................................... 1387<br />
Shigetaka, M ......................................... 1703<br />
Shih, D ................................................... 1373<br />
Shih, D M ............................................... 1949<br />
Shih, T .............................................. 776, 785<br />
Shih, T M ................................................. 787<br />
Shima, H .................................................. 451<br />
Shimada, A .....................................605, 700*<br />
Shimada, N ............................................ 1904<br />
Shimamura, N ....................................... 1251<br />
Shimbo, S ............................................... 2064<br />
Shimizu, J ................................................ 210<br />
Shimomoto, M ........................................ 834<br />
Shin, C ...................................................... 256<br />
Shin, D .............................1409, 1423*, 1427,<br />
.............................................. 1524, 1531, 2169<br />
Shin, J ..................................................... 1261<br />
Shin-Darlak, C ...................................... 2235<br />
Shindo, A ............................................... 2037<br />
Shinohara, Y .......................................... 2277<br />
Shioda, A ................................................ 1633<br />
Shioda, S .......................................... 988, 989<br />
Shiotani, M .....................................831, 837*<br />
Shipp, A ................................................... 398<br />
Shirai, M .................................................. 954<br />
Shirai, T ...................... 765, 1379, 1388, 1424<br />
Shiverick, K .................................. 370, 1113*<br />
Shock, S S ............................................... 1387<br />
Shoki, M ................................................... 833<br />
Shokouhi, B ........................................... 2225<br />
Short, B G ..............................................6, 12*<br />
Shost, S J ................................................ 1288<br />
Showker, J L .......................................... 1391<br />
Shows, E B ............................................. 1299<br />
Shreve, K ................................................ 1516<br />
Shreve, K W ............................................1185<br />
Shuey, D ................................................2210*<br />
Shugar, D ................................................. 817<br />
Shultz, R L ............................................. 1093<br />
Shultz, V .......................................... 560, 577<br />
Shum, M .................................................. 412<br />
Shuto, R .................................................1742*<br />
Shvedova, A ............................................ 705<br />
Shvedova, A A ............. 701, 702, 2188, 2282<br />
Siacotos, T J ............................................. 473<br />
Sibanushi, T ............................................. 799<br />
Sibiril, Y ..................................................1175<br />
Sickles, D ............................................... 1553<br />
Sickles, D W .........................................1552*<br />
Siddens, L K .......................................... 1499<br />
Siddiqi, H K ........................................... 1062<br />
Siddiqui, W ............................................949*<br />
Sidhu, J ................................................... 1655<br />
Sidhu, J S .......................................1155, 2257<br />
Siegel, D M .............................................. 254<br />
Siegel, P D ...............................................1211<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Siegers, C .................................... 397*, 1403*<br />
Sierra-Santoyo, A .................................1568*<br />
Sifre, M ....................................................1114<br />
Signs, S ................................................... 2192<br />
Sigolaeva, L V ......................................... 192<br />
Silbajoris, R ...........................................1450*<br />
Silber, P M .................................... 1263, 2014<br />
Silbergeld, E ............................................ 879<br />
Silbergeld, E K ..............................430*, 627,<br />
........................................... 1148, 1326*, 1331*<br />
Silkworth, J ................................................ 93<br />
Silkworth, J B .............................. 2044, 2056<br />
Sills, R C ................................................. 1091<br />
Silva, V M ...............................................698*<br />
Silva, W I ............................................... 1539<br />
Silver, D ...................................................420*<br />
Silverstone, A E ....................................... 881<br />
Sim, E ..................................................... 1266<br />
Simeonova, P ........................................ 1713<br />
Simeonova, P P ....................................... 705<br />
Simmen, F A ........................ 274, 1918, 1919<br />
Simmonds, P L .............................. 184, 1216<br />
Simmons, J ..........................408, 1292, 1934*<br />
Simmons, T W .............................. 321*, 322*<br />
Simon, S ................................................. 1750<br />
Simon, S L ...............................................331*<br />
Simpson, D A ...........................................119<br />
Sina, J ........................................................ 121<br />
Sinclair, J F ....................... 65, 137, 218, 1049<br />
Sinclair, P R ...............................65, 137, 218*<br />
Singh, A V .............................................. 1984<br />
Singh, J ................................................... 1915<br />
Singh, M ....................................... 2004, 2190<br />
Singh, N P .............................................1866*<br />
Singh, P .................................................1214*<br />
Singh, R .............................. 1616, 1740, 2066<br />
Singh, R K .............................................1614*<br />
Singh, S .................................................. 1588<br />
Singh, S P ..............................................2217*<br />
Singh, V ................................................. 1313<br />
Singleton, S .............................................1144<br />
Sinz, M ..................................................... 719<br />
Sioutas, C ............................................... 1453<br />
Sistare, F ................................................. 1513<br />
Sistare, F D .............................................. 121<br />
Sistrunk, S C ................................ 1947, 1955<br />
Sivils, J .....................................................576*<br />
Sizemore, A ................................... 484, 2001<br />
Skakkebaek, N E ..................................... 255<br />
Skare, J ..................................................... 733<br />
Skillman, A D ........................................ 1586<br />
Skinner, A .............................................2235*<br />
Slikker, W .......................... 673*, 674*, 1098,<br />
...................................1099, 1702, 1979*, 2285<br />
Slim, R ................................................... 1195*<br />
Slim, R M ................................................. 180<br />
Slitt, A L ................................815*, 821, 1761<br />
Slitt, A M .................................................... 67<br />
Sloan, C .................................................... 732<br />
Sloan, C S ................................................547*<br />
Sloter, E .................................................... 231<br />
Sloter, E D .......................................239, 240*<br />
Slotkin, T A .................. 964, 965, 1068, 1069<br />
Smalstig, T ............................................... 412<br />
Smart, D ................................................2234*<br />
Smart, E .................................................. 1838<br />
Smith, A ......................................... 670, 1089<br />
Smith, A G ............................................1903*<br />
Smith, B .................................................... 884<br />
Smith, C ... 194, 391, 1233, 1234, 2069, 2086<br />
Smith, C J ............................................... 1294<br />
Smith, C S .............................................. 2129<br />
Smith, C V ................................... 1726, 1854<br />
Smith, D ................................................... 598<br />
Smith, D J ................................................760*<br />
Smith, D R ..............................597, 629, 630*<br />
Smith, E L .............................................1533*<br />
Smith, H ................................................. 1992<br />
Smith, J ................................................... 1420<br />
Smith, J B ............................................... 2299<br />
Smith, J P ................................................. 772<br />
Smith, K R ..............................................504*<br />
Smith, M ........................................ 861, 2065<br />
Smith, M A ............................................. 1395<br />
Smith, M D ...........................................2240*<br />
Smith, M T ............................................. 1301<br />
Smith, M V ...........................................1302*<br />
Smith, P A .................................... 1508, 1509<br />
Smith, P F ............................................... 2027<br />
Smith, P J ............................................... 1537<br />
Smith, R D ............................................... 918<br />
Smith, R G ............................................... 635<br />
Smith, S M ............................................. 2246<br />
Smith, T .................................................... 356<br />
Smith, W J .................... 777, 782, 2201, 2202<br />
Smith-Roe, S .........................................2273*<br />
Smithson, S .............................................. 766<br />
Smitz, J ..........................................1123, 1366<br />
Smoller, S ................................................. 982<br />
Smyth, S ................................................. 1840<br />
Snawder, J E ............................................ 772<br />
Snellings, W M .....................................1256*<br />
Snodgrass, B R .....................................1556*<br />
Snow, T A ............................................... 1578<br />
Snyder, R ................................ 260, 361, 1842<br />
Snyder, R D ..........................................1040*<br />
Snyder, R W ............................................. 505<br />
Snyder, T ................................................ 1630<br />
Snyder-Keller, A .................................... 1083<br />
Sobel, E S ................................................. 909<br />
Sobieszczyk, MD PhD, A ..................... 1668<br />
Sochaski, M A ....................................... 1228<br />
Soderstrom, C ......................................... 171<br />
Soekeland, J ........................................... 1269<br />
Soelberg, J ................................................ 233<br />
Soelberg, J J .............................................. 232<br />
Sohn, H .................................................. 1217<br />
Sohn, J .................................................... 1261<br />
Sokolov, V B ...................... 1936, 1937, 1938<br />
Sokolovskaya, L G .................................. 192<br />
Solis-Heredia, M ....................................1147<br />
Soloviev, M .............................................473*<br />
Somji, S ...................1606*, 1614, 1616, 1618<br />
Sommer, R J ........................................... 1831<br />
Sommerville, D R ................................... 788<br />
Sonawane, B .................................. 378, 1978<br />
Sone, H ..................................................1376*<br />
Sone, T .................................................... 1617<br />
Song, A ..................................................... 806<br />
Song, Y ................................353, 1226*, 2186<br />
Soni, M G ..................................................35*<br />
Sonich-Mullin, C .................................... 328<br />
Sonnewald, U .......................................... 620<br />
Sono, S ...........................................1192, 1193<br />
Soos, J M .................................................. 910<br />
Sopori, M ..................................................21*<br />
Sordo, M .......................................1146, 1455<br />
Sorrentino, C ........................353, 1129, 1361<br />
Soshilov, A ............................................... 353<br />
Soucy, N V .................................. 1162, 1228*<br />
Sousa, R B .............................................. 1835<br />
South, N ................................................... 391<br />
Spainhour, C B ...........................1418*, 2029<br />
Spalding, S ............................................. 1512<br />
Speal, B A ................................................. 910<br />
Spear, B T ..................................... 1487, 1488<br />
Spence, F ................................................ 2205<br />
Spencer, P J ................................. 2211*, 2224<br />
Spencer, P S ..............578*, 1549, 1550, 1551<br />
Spencer, W A ........................................2269*<br />
Spiegl, N M ..........................................1262*<br />
Spirkl, H ................................................. 1038<br />
Spletter, M L ............................................ 984<br />
Sprague, G L ............................................ 372<br />
Spriggs, D ...............................................1184<br />
Springer, D .............................................355*<br />
Sprugel, K ................................................ 461<br />
Squibb, K ................................................. 163<br />
Squibb, K S .................165*, 632, 1262, 1451<br />
Srinivasan, V ........................................... 790<br />
Sriram, K ...............................................1223*<br />
Srivastava, P .......................................... 1924<br />
Srivastava, S ........................ 691, 1844, 1876<br />
St-Pierre, A ............................................... 558<br />
St. Jeor, S ................................................ 1009<br />
Stachlewitz, R F .....................................462*<br />
Stadler, J C ............................................... 952<br />
Staedtler, F ................................................. 61<br />
Stahl, N .................................................. 1470<br />
Stammberger, I .............................. 510, 1038<br />
Stams, K ................................................. 2291<br />
Stamyr, K ................................................. 352<br />
Stanley, L .................................................733*<br />
Stapelton, P L ........................................ 1495<br />
Stapleton, A R ................................571, 963*<br />
Stapleton, B ............................................715*<br />
up-to-date information at www.toxicology.org 241<br />
Stapleton, P ........................................... 1584<br />
Stapleton, P L ........................................ 2244<br />
Stark, J .................................................... 1898<br />
Starmer, R ................................................ 768<br />
Staskal, D ........................................ 310, 311*<br />
Staskal, D F ............................................ 1253<br />
States, J ..........................689, 690, 691*, 1267<br />
Stauber, A J ...................................582*, 2286<br />
Staudenmayer, J W ............................... 1281<br />
Stavanja, M S ........................................ 1187*<br />
Stearns, D M ............................ 157, 158, 159<br />
Steele, T D .....................................872*, 1878<br />
Steevens, J A .......................................... 1585<br />
Steever, K ................................................. 540<br />
Steffensen, K R .................................... 57, 59<br />
Steffy, D A .............................................. 1589<br />
Stegall, V ................................................ 1067<br />
Stehfest, E .............................................. 1461<br />
Steigerwalt, R .......................................... 461<br />
Stein, G S ................................................ 1032<br />
Stein, T D ................................................. 985<br />
Steiner, S ................................ 64, 1005, 1900<br />
Steiner, S R ............................................. 1535<br />
Steinmetz, K ............................... 801*, 1095*<br />
Stelck, R ................................................... 210<br />
Stemm, D N ................................1487*, 1488<br />
Stemmer, K ........................................... 2114*<br />
Stenner, R D ........................................... 1003<br />
Stephenson, A P .....................................615*<br />
Steppan, L B .......................................... 1873<br />
Sterling, S ................................................328*<br />
Sterner, T R .................................1305, 2078*<br />
Stevens, G J ...................................... 488, 515<br />
Stevens, J T ............................................ 1738<br />
Stevens, S C ........................................... 2174<br />
Stevens, T ..............................................1894*<br />
Stewart, C ................................................ 802<br />
Stewart, J ...........................................27*, 375<br />
Stewart, J K ............................................ 1639<br />
Stewart, K E ............................................. 254<br />
Stickney, J A ............................................399*<br />
Stierum, R .............................................. 1560<br />
Stifelman, M L ......................................2082*<br />
Stilianesis, M ................................479*, 1780<br />
Still, K R ................................................... 545<br />
Stineman, C ............................................. 428<br />
Stinn, W ................................................1518*<br />
Stock, A L ................................................425*<br />
Stohs, S ........................................1410*, 2301<br />
Stoker, T E ...................................1728*, 1733<br />
Stokes, W ............................ 484, 1628, 1997,<br />
.............................................. 2005, 2007, 2008<br />
Stokes, W S ....................................660, 661*,<br />
.......................................662, 663, 1351, 1352*<br />
Stolper, G ..............................................1254*<br />
Stoltzfus, R J ............................................ 252<br />
Stone, P ............................................ 574, 941<br />
Stone, S ................................................... 1468<br />
Stoner, G D ............................................ 1486<br />
Stoner, M .................................................. 290<br />
Storer, R D ............................................1028*<br />
Stork, L G ................................................408*<br />
Storm, J E ....................................1093, 1288*<br />
Stott, W .................................................... 670<br />
Stout, M D ..............................................525*<br />
Stoute, M ..............................................1462*<br />
Stoyanovsky, D A ................................. 2284<br />
Strakhova, M ........................................... 557<br />
Strakhova, N N ................... 192, 1936, 1937<br />
Stratford, I J ........................................... 1652<br />
Straube, F ......................................481, 2010*<br />
Strauss, K A ........................................... 1262<br />
Streicker, M .............................................. 844<br />
Stresser, D M ........................................... 719<br />
Strickland, J ..................................484*, 1628<br />
Striley, C A ............................................... 772<br />
Stringer, K F ...........................................1165<br />
Strom, S C .................................... 1049, 1495<br />
Strynar, M J ............................................ 1232<br />
Stuart, E C .............................................1489*<br />
Stuchal, L D ..........................................1596*<br />
Stulnig, T M ......................................... 57, 59<br />
Stump, D G .................................. 3, 239, 275<br />
Stuppner, H ........................................... 2303<br />
Styblo, M .............. 135, 148, 930, 1231, 1817<br />
Styles, J A ................................................1110<br />
Su, T .......................................................... 723<br />
Suarez, J C ............................................... 497<br />
Succop, P ................................................ 1512<br />
Suda, M .......................................... 542, 1080<br />
Sudo, Y ................................................... 1379<br />
Sugawara, T ............................................ 812<br />
Sugden, K D ...........................................1136<br />
Sugita-Konishi, Y ............................ 459, 607<br />
Sugita-Konishi, y ...................................886*<br />
Sugiura, S ..............................................1424*<br />
Sugiura, Y ................................................ 944<br />
Sui, L ......................................................... 982<br />
Sukata, T .................................................750*<br />
Sulentic, C E ...........................................366*<br />
Sullivan, M ............................................ 2120<br />
Sultatos, L ................................................ 860<br />
Sultatos, L G .......................................... 2154<br />
Sumida, K ............................ 750, 1379, 1793<br />
Sun, F ....................................................1526*<br />
Sun, G ........................................... 2144, 2146<br />
Sun, H ..................................................... 112*<br />
Sun, J .................................... 825, 1938, 2133<br />
Sun, N N .................................................. 936<br />
Sun, Y ......................................................183*<br />
Sung, J .................................................... 1454<br />
Sunouchi, M ............................................ 709<br />
Suresh, C .................................................. 613<br />
Sushynski, J M ...................................... 1242<br />
Sutherland, K .......................................... 210<br />
Sutherland, K L ....................................... 917<br />
Sutter, C ....................................................93*<br />
Sutter, T ...................................................... 93<br />
Sutter, T R ............................ 354, 2044, 2056<br />
Sutton, J M ............................................... 962<br />
Sutton, R ................................................ 1386<br />
Suzen, S .................................................1273*<br />
Suzuki, H ........................... 1192, 1193, 1194,<br />
.............................................1394, 1399, 1434*<br />
Suzuki, K ..................................... 1954, 1966<br />
Suzuki, S .................... 765, 1424, 1615, 2213<br />
Suzuki, T .............................. 812, 1954, 1966<br />
Suzuki, Y .................................................. 886<br />
Swanson, C .............. 57, 58, 581, 1372, 2286<br />
Swanson, H ..................................... 85, 1805<br />
Swauger, J E .............1185, 1187, 1515, 1516<br />
Sweatman, B C ........................................ 491<br />
Sweatt, A .................................................. 196<br />
Sweeney, L M .................................236, 237*<br />
Swenberg, J A .................. 193, 198, 523, 525<br />
Swiatek, P J .............................................. 723<br />
Syed, J ...................................................... 462<br />
Sykes, G ................................................... 945<br />
Sykes, G P ...................................... 951, 1405<br />
Sylvester, A J ............................................ 774<br />
Symons, M J ............................................ 428<br />
Syversen, T ...................................... 595, 620<br />
Syversen, T L ........................................... 599<br />
Szabo, N J ...............................................696*<br />
Szilagyi, M ................................... 1998, 2017<br />
T<br />
Ta, T N ...................................................2053*<br />
Tack, J ..................................................... 1950<br />
Tahara, M ..............................................2155*<br />
Tai, J K .................................................... 1491<br />
Tak, W .................................................... 1046<br />
Takada, S .................................................. 267<br />
Takahashi, M ....................... 799, 1640, 1727<br />
Takahashi, S ........................................... 1424<br />
Takahashi, Y .......................................... 1432<br />
Takasaki, W ........................................... 2213<br />
Takechi, M ............................................. 1459<br />
Takeuchi, H ........................................... 1471<br />
Takeuchi, Y .................................... 278, 2142<br />
Takewaki, T ................................. 1954, 1966<br />
Takeyoshi, M ......................................... 1727<br />
Takiguchi, M ........................................1615*<br />
Tal, T ....................................................... 1450<br />
Talaska, G .............................................. 2267<br />
Talbot, P ..................................................1115<br />
Talmage, S S ...............................1473, 1485*<br />
Tamai, A ................................................... 834<br />
Tamaki, Y ............................................... 1394<br />
Tamano, S ................................................ 746<br />
Tamura, K ...............................................561*<br />
Tan, J ....................................................... 2183<br />
Tan, M ...................................................... 710<br />
Tan, Y ...............................34, 403, 404*, 1297
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Tan, Z ........................................................99*<br />
Tanaka, A K ............................................. 945<br />
Tanaka, H ................................................. 709<br />
Tanaka, K ............................................... 1617<br />
Tanaka, S .....................................1740, 2066*<br />
Tang, J ....................................................2145*<br />
Tang, L ................................ 1308, 1309, 1595<br />
Tang, Y ................................................... 1308<br />
Tanguay, R ............................................. 2243<br />
Tanguay, R L ................ 88, 2237, 2241, 2242<br />
Tanhehco, E ............................................839*<br />
Taniguchi, R .......................................... 1703<br />
Tanji, M .................................................. 1432<br />
Tank, A ................................................... 1530<br />
Tannenbaum, S R .................................1007*<br />
Tao, L .....................................................1788*<br />
Tapia-Santos, B ..................................... 1467<br />
Tapscott, N .............................................. 472<br />
Tarabelsi, L .............................................. 719<br />
Tarantino, L M ..................................... 1129*<br />
Tardif, R ..........................................244, 851*<br />
Tarkowski, M ........................................ 1712<br />
Tarl<strong>of</strong>f, J B ...............................213, 321, 323*<br />
Tashiro, C ............................................... 1363<br />
Tashkin, D P ............................................ 926<br />
Taylor, B ..........................................689, 690*<br />
Taylor, J ........................ 64, 1005, 1402, 1900<br />
Taylor, J F ..............................................1400*<br />
Taylor, M J ............................................... 473<br />
Taylor, M L ...................................... 770, 771<br />
Taylor, P ..................................................997*<br />
Tchao, R ........................................ 70, 81, 216<br />
Tchounwou, P B .................................... 1858<br />
Teeguarden, J .......................................... 671<br />
Teeguarden, J G .....................................854*<br />
Tegelenbosch, M M ................................ 953<br />
Teng, N ..................................................... 801<br />
Tennant, A H ........................................... 152<br />
Tennant, D A ......................................... 1652<br />
Tennant, R .................................................. 60<br />
Tennant, R W ......................... 64, 1005, 1900<br />
Tenneson, K .................................. 841, 1102*<br />
Teranishi, M .......................................... 1433<br />
Teraoka, H ............................................2037*<br />
Terasaka, S ............................................. 1432<br />
Terneus, M ................................................66*<br />
Terranova, P F ............................. 2034, 2048<br />
Terry, K K ................................................1121<br />
Teske, S ....................................................875*<br />
Testino, A ............................................... 1552<br />
Tewksbury, E ......................................... 1467<br />
Thackaberry, E A ...................................845*<br />
Thai, S ...................... 2144, 2146, 2147, 2149<br />
Tharappel, J C ............................1487, 1488*<br />
Thatcher, G R .............................. 1573, 2274<br />
Thayer, W C .......................................... 2082<br />
Theobald, H M .......................................... 87<br />
Theophilus, E H ................................... 1185*<br />
Thibault, S ............................................... 798<br />
Thibodeaux, J ...............................280*, 2066<br />
Thibodeaux, J R .......................... 1232, 2144<br />
Thiel, M ...................................................2114<br />
Thier, R ................................................... 1269<br />
Thilagar, A ................................... 1927, 2215<br />
Thillainadarajah, I ................................ 2151<br />
Thiruchelvam, M ........................... 217, 645,<br />
.............................................1957, 1958*, 1965<br />
Thomas, B ...............................................1126<br />
Thomas, C E ...........................................519*<br />
Thomas, D J ................. 148, 692, 1231, 1817<br />
Thomas, F ................................................ 376<br />
Thomas, H C ......................................... 1828<br />
Thomas, J H ........................................... 1758<br />
Thomas, K ............................................1307*<br />
Thomas, P E ............................................. 721<br />
Thomas, R .............................................. 1484<br />
Thomas, R S ................................. 1218, 1222<br />
Thomas, S ................................................ 982<br />
Thomas, T ................................................ 378<br />
Thomas, T W ........................................1225*<br />
Thomford, P J .......................................... 804<br />
Thompson, C ................................181, 2208*<br />
Thompson, C M .............................. 378, 859<br />
Thompson, K .......................................... 121<br />
Thompson, K E ............................. 188, 2151<br />
Thompson, R ............................................911<br />
Thompson, S ........................................... 785<br />
Thomson, S .............................. 776, 793, 794<br />
Thomson, S A .......... 773, 775, 786, 787, 788<br />
Thorpe, P E ...................................... 802, 803<br />
Thrall, B D ............................................. 1003<br />
Thrall, K D ..............................232*, 238, 866<br />
Thran, B ................................................... 329<br />
Threadgill, D ......................................... 1046<br />
Threadgill, D W ...................... 60, 712, 1840<br />
Thrippleton, K A ..................................1590*<br />
Thuett, K A .....................................618*, 619<br />
Thurmond, T S .......................................... 39<br />
Thygesen, H V ...................................... 1390<br />
Tian, B .....................................................797*<br />
Tian, Y .............................................. 107, 721<br />
Tibbetts, B ................................................ 527<br />
Tice, R .................................. 484, 1628, 1997,<br />
.............................................. 2005, 2007, 2008<br />
Tice, R R ........................................... 662, 663<br />
Tierney, L A ............................................ 1828<br />
Tiesman, J P ........................................... 1371<br />
Tietge, J .................................................. 1755<br />
Tietge, J E ..................................... 1754, 1756<br />
Tiffany-Castiglioni, E ............................ 614,<br />
...............................................999*, 2132, 2170<br />
Tigner, J C .................................................. 10<br />
Tillander, S ............................................. 1885<br />
Tiller, M .................................................... 606<br />
Tillis, V ................................................... 2240<br />
Tillitt, D E .............................................. 1289<br />
Tilton, F .................................................2237*<br />
Tilton, S C ...............................................758*<br />
Timchalk, C ................................ 1150, 1336*<br />
Tina, R ...................................................... 797<br />
Tinkle, S S ...............................................1129<br />
Tinwell, H ............................ 124, 1736, 1739<br />
Tipple, T E ............................................. 1854<br />
Tirmenstein, M A .................................... 536<br />
Tjalkens, R ..................................1649, 1653*<br />
Tobia, A .................................................. 1297<br />
Tobias, J J ..............................................1576*<br />
Tobias, L ..................................................161*<br />
Tobin, J ..................................................... 949<br />
Tobin, J M ...................................1237*, 1751<br />
Toborek, M ............................................ 1838<br />
Tocker, J .................................................... 499<br />
Toda, Y ..................................................... 742<br />
Todd, A C ................................................1148<br />
Todero, S L ............................................. 2280<br />
Toghill, A ......................................... 743, 744<br />
Tohyama, C ......................... 130, 2043, 2142<br />
Tokado, H ................................................ 496<br />
Tokunaga, H .......................................... 2155<br />
Tolliver-Ho, L ........................................ 2130<br />
Tolson, J K ...............2073, 2074*, 2075, 2076<br />
Tomaszewski, J ..................... 466, 801, 1782<br />
Tomaszewski, J E .............. 1776, 1777, 1778<br />
Tomer, K B ............................. 64, 1005, 1900<br />
Tomic, D ................... 1109*, 1111, 1112, 2153<br />
Tomlinson, D R ..................................... 1652<br />
Tompkins, L M .....................................1765*<br />
Ton, C ..........................................1096, 2018*<br />
Tonetta, S A ...................................718*, 1935<br />
Tong, W .............................1381, 1476, 1704*<br />
Toops, K ................................................... 685<br />
Torky, A W ............................................. 1461<br />
Tornero-Velez, R ............................ 850, 858,<br />
................................................ 870, 1250, 1298<br />
Tornesi, B ............................................... 2249<br />
Tornier, C ................................................. 482<br />
Torontali, S M ........................................ 1371<br />
Torous, D K ........................................... 2212<br />
Torres-Sanchez, L ..................................427*<br />
Toscano, C D ............................................52*<br />
Toselli, P ........................................... 574, 941<br />
Tosheva, R T ............................................ 727<br />
Toshimori, K ............................................ 556<br />
Totsuka, H ......................................117, 1901<br />
Totura, A .................................................. 787<br />
Townsend, D E ...................................... 1313<br />
Toy, K ...................................................... 1916<br />
Toyama, Y ................................................ 556<br />
Toyoda, H .....................................1192, 1193<br />
Toyoshiba, H ............1181, 1376, 2035, 2070<br />
Tozier, N ..................................................1103<br />
Tracy, J H ................................................ 1495<br />
Traina, V M .............................................471*<br />
Tran, D ..................................................... 573<br />
Tran, J ....................................................... 412<br />
Tran, L ...................................................... 681<br />
242<br />
Trang, J M .............................................. 1935<br />
Trask, H W ....................................... 137, 218<br />
Trauner, M ................................................. 63<br />
Travlos, G ........................................ 518, 539<br />
Traynelis, S F ......................................... 1529<br />
Trease, H E ..............................................347*<br />
Trease, L L ................................................ 347<br />
Treinen Moslen, M ................................. 469<br />
Treinen-Moslen, M ....................... 498, 1922<br />
Tremblay, C ............................................. 558<br />
Trepanier, D J ........................................ 1255<br />
Trevena, K A ............................................ 357<br />
Trimmer, G W ............................... 275, 1514<br />
Tripp, L ..................................................... 273<br />
Trivedi, S .................................................779*<br />
Troast, R ................................................... 155<br />
Troester, M A ........................................... 123<br />
Trombetta, L D ............................... 592, 612,<br />
.................................... 1591, 1592, 1827, 1833<br />
Trommer, W E ....................................... 1863<br />
Trosko, J E ...................................... 822, 1501<br />
Troxel, C M .................................1473, 1474*<br />
Truax, J .................................. 662, 663, 1997,<br />
.............................................2005, 2007, 2008*<br />
Truchon, G ............................................... 244<br />
Trussell, H J ........................................... 1467<br />
Tsang, M .................................................216*<br />
Tsang, M M .............................................612*<br />
Tsao, M ................................................... 1608<br />
Tsaprailis, G ................................ 1801, 2275<br />
Tse, K F ................................................... 1600<br />
Tseng, H ................................................. 2020<br />
Tshala-Katumbay, D D ....1549, 1550*, 1551<br />
Tsivinsky, A D ........................................468*<br />
Tsuchitani, M ................................ 763, 1459<br />
Tsuchiya, T .............................................176*<br />
Tsuji, J S ......................................... 648*, 693*<br />
Tsuji, R .............................................980*, 981<br />
Tsujimura, K ...........................................765*<br />
Tsukamura, H ......................................... 278<br />
Tsunoda, M .....................459, 607*, 886, 944<br />
Tsunoda, S ..............................................799*<br />
Tsusaki, H ........................................ 496, 834<br />
Tsutsui, N .............................................. 1904<br />
Tu, T .......................................................... 962<br />
Tucker, C J .......................................121, 1176<br />
Tuell, T M ............................................... 1935<br />
Tufariello, E M ...........................2073*, 2075<br />
Tugendreich, S ...............................126, 495*<br />
Tugwood, J D .......................................1276*<br />
Tukey, R H ............................................. 1360<br />
Tumbleson, M E ........................1310, 1312*,<br />
.................................... 1313, 1314, 1315, 1929<br />
Tung, K ..................................................... 310<br />
Tung, K C ............................................... 2072<br />
Tuomisto, J ............................................. 2042<br />
Turkall, R M .......................................... 1923<br />
Turker, M ............................................... 2235<br />
Turner, J N ............................................... 189<br />
Turner, S ................................................1898*<br />
Turpaz, Y ............................. 121, 1819, 2150<br />
Twaddle, N C .................................. 293, 361<br />
Tward, A ................................................ 1949<br />
Twaroski, M ................................. 1317, 2204<br />
Twerdok, L ...............................................23*<br />
Tyagi, G .............................1310, 1314*, 1315<br />
Tyl, R W ................................................... 547<br />
Tyson, C A ........................ 1170*, 1907, 1908<br />
Tyurin, V A ......................2284, 2294*, 2295,<br />
........................................................ 2296, 2297<br />
Tyurina, Y Y ................................ 2284, 2294,<br />
.............................................2295, 2296, 2297*<br />
U<br />
Uchino, T ................................................. 833<br />
Uddin, A N ............................................ 1045<br />
Ueda, H ................................................... 117*<br />
Ueng, T ...................................................566*<br />
Uetrecht, J P ............................................. 904<br />
Uetsuka, K ............................................. 1433<br />
Ullmann, L G ..........................................1199<br />
Ulrich, R G ......................................... 56, 589<br />
Umantsev, A ............................................ 976<br />
Umemura, T ............. 211, 1406, 1428*, 1861<br />
Unami, A .....................................1793, 2277*<br />
Unfricht, D .....................................196*, 894<br />
Unice, K ....................................................411<br />
Uno, H .........................................1456*, 1610<br />
Uno, S ....................................................... 955<br />
Upadhyay, S .........................................1241*<br />
Upham, B ................................................822*<br />
Upham, B L ........................................... 1501<br />
Uppu, R ................................................... 932<br />
Uppu, R M .................................. 200*, 1566*<br />
Upton, P B ............................................... 523<br />
Urda, E ......................................... 1049, 1916<br />
Ure, D ..................................................... 1255<br />
Urushidani, T .......117, 561, 562, 1901, 1902<br />
Usmani, K A ...........................................726*<br />
Ustyugova, I V .....................................1889*<br />
Usuka, J .................................................... 348<br />
Usuki, E ..................................................1174<br />
Utell, M J .................................................. 848<br />
Utrecht, J .................................................. 375<br />
Utsumi, H .............................................. 1904<br />
Uwagawa, S ............................................ 750<br />
V<br />
Vachon, S ................................................. 480<br />
Vaghjiani, R J ..........................................1133<br />
Vahey, M .................................................. 793<br />
Vahidnia, A .............................................634*<br />
Vaidya, V S .............................................197*<br />
Vakharia, J ............................................. 1383<br />
Valdes, J J ................................................. 793<br />
Valencia, F ............................................... 614<br />
Valentin, J ................................................ 824<br />
Valentine, R ............................................. 951<br />
Valentovic, M .................................66, 2134*<br />
Valerio, M .................................................114<br />
Vallant, M .........484, 1181, 1628, 2035, 2070<br />
Vallyathan, V ..........................................1157<br />
Van Beneden, R J .................................. 2022<br />
Van Bree, L ............................................. 1446<br />
van Breemen, R B ................................. 2274<br />
van Dael, M ........................................... 1057<br />
van de Bovenkamp, M .......................1913*<br />
van den Berg, M .......................... 513, 1734,<br />
.............................................. 1747, 1748, 2059<br />
van den Berg, P ....................................... 177<br />
van der Hoek, J ....................................... 426<br />
van der Horst, L .......................... 1056, 1057<br />
van der Laan, G ...................................... 426<br />
van der Ven, L ....................................... 2061<br />
van Duursen, M .....................................513*<br />
Van Fleet, J ............................................... 269<br />
van Gemert, M ...................................... 1505<br />
Van Goethem, F ...................................... 481<br />
van Hout, M ............................................ 426<br />
Van Kampen, K R ................................. 1515<br />
Van Kerkhove, M D ............................... 693<br />
Van Kranen, H ...................................... 1490<br />
Van Merris, V ........................................ 1366<br />
Van Miert, E .................................922, 2226*<br />
van Ommen, B .........................................36*<br />
Van Pay, L M ........................................1364*<br />
Van Sande, J ........................................... 1039<br />
van Steeg, H ............................................ 929<br />
Van Vleet, T R ....................................... 1795<br />
Van Wemmel, K .....................................1123<br />
van Wijk, F ............................................1205*<br />
Van Winkle, L S ..............................210*, 917<br />
van Zijverden, M ...................................177*<br />
Vancza, E M ............................................880*<br />
Vande Vannet, B ....................................1188<br />
Vanden Heuvel, J ...................................... 40<br />
Vanden Heuvel, J P ............................ 53, 54<br />
Vandervoet, G B .............................. 606, 634<br />
Vandestouwe, K .................................... 1468<br />
Vanoirbeek, J ........................................1712*<br />
Vansant, G ..............................................754*<br />
Vanscheeuwijck, P .......................922*, 2226<br />
Vargas, G ................................................. 825<br />
Varnum, S M ......................................... 1003<br />
Vasconcelos, D ...................1181, 2035, 2070<br />
Vassallo, J D .......................................... 1197*<br />
Vassieva, O .............................................. 761<br />
Vaudry, D ............................................... 2300<br />
Vaudry, H .............................................. 2300<br />
Vaughn, C ................................................ 254<br />
Vedula, U ............................................... 1075<br />
Velazquez, G ........................................1539*<br />
SOT's 44 th Annual Meeting
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
AUTHOR INDEX<br />
Vellareddy, A ......................................... 1527<br />
Vemuri, M C ............................................ 613<br />
Veneziale, R ............................................. 798<br />
Vengellur, A .......................................... 1130*<br />
Venkatakrishnan, P .....................229*, 1860<br />
Venkatapathy, R ...................285, 383, 1520*<br />
Vera, E .....................................................1146<br />
Veranth, J M ...........................................304*<br />
Verberk, M ..............................................426*<br />
Verberk, M M ........................................ 2199<br />
Verderber, E ............................................. 766<br />
Verhoef, A .............................................. 1490<br />
Verina, T ................................................1542*<br />
Vermeern, A ........................................... 1522<br />
Vermeulen, R ......................................... 1301<br />
Veronesi, B ..........................204, 1445*, 1964<br />
Veselica, M ............................................. 1252<br />
Vetrano, A M ......................................... 2171<br />
Vezina, C ...................................................87*<br />
Vezina, C M ................................. 2038, 2045<br />
Vezina, M ................................477, 840, 841*<br />
Viau, A ................................ 1458, 1462, 1464<br />
Viau, C ..................................................... 244<br />
Viberg, H ....................312*, 405, 1074, 2062<br />
Vick, K D .................................................. 547<br />
Vickers, A E ..........................................1914*<br />
Victorin, K ............................................... 405<br />
Vidali, M .................................................. 906<br />
Vietti, K R ................................................ 628<br />
Vigoren, E .............................................. 1303<br />
Villano, C M ................ 102, 120, 2000, 2239<br />
Villeneuve, D ........................................ 1583<br />
Villeneuve, D L ....................................1746*<br />
Viluksela, M ............................................ 679<br />
Vincent, J B ............................................ 1067<br />
Visalli, T ................................................. 1923<br />
Visich, J .................................................... 800<br />
Vittorelli, A ............................................ 2135<br />
Vivas, R .................................................. 1708<br />
Vladimirov, Y A .................................... 2284<br />
Vladimirova, A ..............................126, 522*<br />
Vodela, J ................................................1386*<br />
Voelkel, W ............................................. 1239<br />
Vogel, C F ..............................................1442*<br />
Vogel, F .......................................... 478, 2025<br />
Volz, D C ................................................ 1582<br />
von Holt, K .............................................924*<br />
von Recklinghausen, U ....................... 2225<br />
von Recklinghausen, U V .................... 1818<br />
von Rosen, D ................................. 405, 1074<br />
Vorhees, D J ........................................... 2078<br />
Voss, K A .............59, 582, 1391, 1396*, 2286<br />
Vu, B ....................................................... 1780<br />
Vudathala, D ......................................... 1815<br />
Vugmeyster, Y ......................................... 806<br />
Vulimiri, S .............................................. 1517<br />
Vulimiri, S V .......................................... 2229<br />
Vulpe, C D ............................................. 1585<br />
Vyskocil, A ..............................................244*<br />
W<br />
Waalkens, I .................................. 1056, 1057<br />
Waalkens-Berendsen, I D .....................953*<br />
Waalkes, M ............136, 138, 141, 144, 694*,<br />
.......................................................... 817, 1608<br />
Waalkes, M P ............... 582, 593, 1619, 1817<br />
Waanders, M ......................................... 1056<br />
Wachholz, P ..........................................1204*<br />
Wachter, E ................................................ 493<br />
Wade, M J .............................................. 2079<br />
Waechter, F ...................................... 743, 744<br />
Waechter, J M .................................854, 2211<br />
Wagner, G C ............................................ 983<br />
Wagner, J G .............................438*, 439, 449<br />
Waidyanatha, S ..................................... 1301<br />
Wakamatsu, Y ....................................... 1703<br />
Wakefield, J ..........................................2173*<br />
Wakefield, L .......................................... 1266<br />
Wako, K .................................................1459*<br />
Walker, C C ............................................ 1598<br />
Walker, D B .............................................. 497<br />
Walker, H ............................................... 1386<br />
Walker, J C ..............................................497*<br />
Walker, K ............................................... 1978<br />
Walker, M K ........................... 845, 846, 1837<br />
Walker, N ....................362, 1181, 2035, 2070<br />
Walker, N J ...............................33*, 497, 852,<br />
.............................................1506, 1699*, 1821<br />
Walker, S ...............................................1498*<br />
Walker, V ................................................. 523<br />
Walker, V E .............................................. 198<br />
Wallace, A D .......................................... 1765<br />
Wallace, K .................................... 1740, 2066<br />
Wallace, K A ............................................ 142<br />
Wallace, K B ...... 206, 827, 1835, 1849, 1906<br />
Wallace, W E ......................................... 2223<br />
Waller, D P ..............................................734*<br />
Wallo, A .................................................... 332<br />
Walmsley, R M .....................................1037*<br />
Walraven, J M .......................................1265*<br />
Walter, B ................................................... 968<br />
Walter, B J .............................................. 1949<br />
Walter, G ...................................................... 4<br />
Walters, E M ............................................ 546<br />
Walton, C L ............................................ 1889<br />
Walton-Strong, B W ................................. 65<br />
Wamer, W G .................................. 502, 2187<br />
Wan, J ....................................569, 755, 1850*<br />
Wan, Y Y ...........................1050, 1766*, 1920<br />
Wang, A .................................................. 1816<br />
Wang, B ...................................................1165<br />
Wang, C ................................................2285*<br />
Wang, F ....................................... 909*, 1770*<br />
Wang, G ...................503, 1156*, 1159, 2071*<br />
Wang, H ........................................... 171, 278<br />
Wang, J .................. 34, 348, 738, 1281, 1283,<br />
...................... 1297*, 1308, 1309*, 1402, 1493,<br />
..................................1565, 1595, 1810, 1836*,<br />
.............................................2019, 2216*, 2222<br />
Wang, J - ................................................... 221<br />
Wang, K ................................................... 527<br />
Wang, M Z ............................................... 973<br />
Wang, P .................................................. 1595<br />
Wang, R ...............................542*, 1080, 1583<br />
Wang, S X ................................................. 590<br />
Wang, T ...................................................461*<br />
Wang, W .............................228*, 1571, 1788<br />
Wang, X ....................................... 594*, 2253*<br />
Wang, Y .................................560, 577, 1541*<br />
Wang, Y Y .................................... 2183, 2184<br />
Wang, Z .............................. 1308, 1309, 1595<br />
Wang-Buhler, J .....................................2020*<br />
Wang-Fan, W ....................................... 1199*<br />
Wanibuchi, H .......................................... 746<br />
Warbritton, A ........................ 62, 1910, 2137<br />
Warbritton, A R ........................... 2185, 2187<br />
Ward, D .................................................... 887<br />
Ward, J .................................................... 1042<br />
Ward, J M ............................................... 1704<br />
Ward, M ................................................1213*<br />
Ward, M D ............................................. 1714<br />
Ward, S ..................................................... 844<br />
Ward, T R ............................................... 1081<br />
Ward, W ..................2144, 2146, 2147*, 2149<br />
Warfe, L .................................................. 2120<br />
Warheit, D ................................................ 704<br />
Warheit, D B ............................. 1, 651*, 703*<br />
Waring, J ...........................................113, 557<br />
Waring, J F ....................................... 121, 647<br />
Warner, B ................................................. 103<br />
Warren, D ................................................ 861<br />
Warren, M E ...........................................109*<br />
Warren, N .............................................. 2009<br />
Warshawsky, D ..................103*, 1512, 2267<br />
Wasdo, S C ....................................696, 2186*<br />
Washer, G ........................................203, 480*<br />
Wassenberg, D .............................. 687, 1581<br />
Watabe, H .............................................. 1399<br />
Watanabe, A ...........................................1611<br />
Watanabe, C ......................... 604, 605, 1611*<br />
Watanabe, H ............................................ 176<br />
Watanabe, J ...........................................1318*<br />
Waterfield, C ..........................................744*<br />
Waterland, R A ........................................ 572<br />
Waters, K M ............................................. 122<br />
Waters, M D .................................... 64, 1709<br />
Waters, S B ............................................... 148<br />
Watkins, J B ..........................................1401*<br />
Watkinson, W P .............................. 433, 441<br />
Watson, J G .............................................. 304<br />
Watson, P S .............................................. 465<br />
Watson, R E ..........................................2097*<br />
Watson, S J ............................................. 1935<br />
Watson, T M ............................................ 806<br />
up-to-date information at www.toxicology.org 243<br />
Watson, W H ...............654*, 655*, 659*, 820<br />
Watterson, T L ......................................1795*<br />
Watts, G S .......................................146, 1161<br />
Watts, J ................................................... 1598<br />
Watts, W ................................................... 443<br />
Way, R ...................................................... 793<br />
Way, R A ................................................... 775<br />
Weaver, J L ....................................902*, 1842<br />
Weaver, V M ......................................... 1148*<br />
Webb, T ............................................ 703, 704<br />
Webb-Robertson, B ..............................1705*<br />
Webber, M ................................................ 141<br />
Weber, E J ............................................... 2065<br />
Weber, J .................................................. 2156<br />
Weeks, J .................................................1286*<br />
Weeks, J A .............................................. 1758<br />
Wei, M .................................................... 1502<br />
Wei, W .................................................... 1062<br />
Wei, X ..................................................... 1801<br />
Wei, Y ..................................................... 1845<br />
Weig, B C ................................................610*<br />
Weinbauer, G ........................167, 948*, 2025<br />
Weiner, M L ..................................978*, 1397<br />
Weinrich, A J .........................................1477*<br />
Weir, A ...................................................1990*<br />
Weisman, W H ...................................... 2078<br />
Weiss, T .................................................1282*<br />
Weissert, J L ............................................943*<br />
Weissman, B .......................................... 1791<br />
Weissman, D N ......................................1211<br />
Weitz, K K ............................................. 1150*<br />
Wekking, E .............................................. 426<br />
Welch, N .................................................. 629<br />
Weller, D ................................................ 1246<br />
Weller, P ................................................... 348<br />
Wells, C S ............................................... 2083<br />
Wells, D F ................................................. 530<br />
Wells, P G ..................................... 1077, 2250<br />
Welsch, F .................................................271*<br />
Welsh, P ......................................1258, 2077*<br />
Welty, S E ....................................1726, 1854*<br />
Wen, J ......................................................1148<br />
Wen, S ......................................170*, 544, 807<br />
Weng, C C ................................................ 541<br />
Wenk, M ......................................... 484, 1628<br />
Wentworth, J ....................................86, 100*<br />
West, J L ................................................. 1862<br />
West, K ..................................................... 879<br />
Wester, R C ............................................ 2084<br />
Westerink, M ........................................... 766<br />
Westrick, M P .......................................... 526<br />
Wetmore, B A ........................ 64, 1005, 1900<br />
Wexler, P ................................... 1020*, 1021*<br />
Whalley, C ............................... 776, 785, 793<br />
Whalley, C E ...........................................787*<br />
Wheeler, D A ........................................1969*<br />
Wheeler, M ............................................ 1046<br />
Wheeler, M T ........................................... 387<br />
Wheelock, A M ....................................... 916<br />
Whelan, H T ................................ 1856, 2245<br />
Whilen, B ............................................... 1365<br />
White, A M ............................................ 1003<br />
White, C ......................................... 813, 1244<br />
White, C A ..................................... 729, 1243<br />
White, I .................................................... 671<br />
White, I N ...............................................1110<br />
White, K ......................................... 362, 2069<br />
White, K L .......................................... 23, 178<br />
White, L A ...................102, 120*, 2000, 2239<br />
White, R ................................................... 428<br />
White, R L .............................................. 2280<br />
White, S .................................................... 681<br />
White Jr, K L .......................................... 1212<br />
White Jr., K L ..................................878*, 891<br />
White, Jr., K L ........................................ 1716<br />
Whitehead, G S ....................................1846*<br />
Whitehead, J A .....................................1947*<br />
Whitekus, M J ........................................458*<br />
Whitman, S .............................................. 630<br />
Whitney, K ............................................... 557<br />
Whitsett, J A .........................................1644*<br />
Whitsett, T G ........................................1492*<br />
Whitt, R .................................................... 497<br />
Whittaker, M H ...... 1156, 1159*, 2101, 2104<br />
Whittingham, A .......................... 2006, 2009<br />
Wible, B ...................................................835*<br />
Wichers, L B ....................................433*, 438<br />
Wickliffe, J ............................................1042*<br />
Wickliffe, J K ............................... 1274, 2236<br />
Widholm, J J .......................................... 1085<br />
Wier, P J ........................................................ 8<br />
Wierda, D ..............................................1992*<br />
Wijsman, J .............................................. 1916<br />
Wilberding, J ........................................... 684<br />
Wild, S L ..................................................467*<br />
Wiles, M C ............................................. 1402<br />
Wiley, S ................................................... 1003<br />
Wilfong, E ...............................................783*<br />
Wilfong, E R .......................... 545, 792, 1883<br />
Wilga, P C .......................................80, 1932*<br />
Wilkie, W S .............................................947*<br />
Wilkins, S ................................................. 172<br />
Wilkinson, S S ....................................... 1598<br />
Will, M ..................................................... 510<br />
Will, Y ....................................................... 488<br />
Willard-Mack, C ................................... 1641<br />
Willett, K L ............................326*, 354, 1588<br />
William, J ................................................. 817<br />
William, S M .......................................... 1783<br />
Williams, C .............................................. 428<br />
Williams, D E ................................ 758, 1499<br />
Williams, E S ......................................... 2253<br />
Williams, F ............................................. 2173<br />
Williams, G .............................................. 670<br />
Williams, G M ............................... 741, 1500<br />
Williams, H I ..........................................428*<br />
Williams, L D .......................................1395*<br />
Williams, P R ........................................1341*<br />
Williams, R L ......................................... 1279<br />
Williams III, F .......................................... 546<br />
Williamson, M ......................................1088*<br />
Willinger, JD MPH, R ..........................1668*<br />
Willis, L .................................................... 802<br />
Wills, M ................................................. 1104*<br />
Willson, T M ............ 55, 586, 587, 588, 1820<br />
Wilmer, J W ..........................................2224*<br />
Wilson, B W ........................................... 1278<br />
Wilson, C R .............................................501*<br />
Wilson, D ............................................... 1256<br />
Wilson, D M ...........................................282*<br />
Wilson, H ............................................... 1467<br />
Wilson, J P .............................................. 1489<br />
Wilson, P ...............................................1701*<br />
Wilson, S .................................................. 697<br />
Wilson, V L ............................................ 2221<br />
Wilson, V S .......................1374, 1743*, 1744<br />
Wilt, N .......................................... 1630, 2001<br />
Wiman, A ................................................. 428<br />
Wing, M ..................................................172*<br />
Winkfield, E ................................. 2144, 2146<br />
Winn, L M .......................... 1806, 1850, 2259<br />
Winnik, B ............................................... 1958<br />
Winship, K W .......................................... 497<br />
Winstead, J T ......................................... 1598<br />
Wintz, H M ............................................ 1585<br />
Wise, J P .............. 145, 160, 1134, 1135, 1145<br />
Wise, S S ............ 145, 160*, 1134, 1135, 1145<br />
Wishnok, J S .......................................... 1007<br />
Wisse, L .................................................... 921<br />
Wisse, L A ................................................ 919<br />
Witschi, H .............................................. 1013<br />
Witten, M ........................................... 20, 416<br />
Witten, M L .............................................. 936<br />
Wittenburg, A ........................................ 1897<br />
Witthuhn, B ........................................... 1755<br />
Witzmann, F .........................................2180*<br />
Witzmann, F A ...................................... 2183<br />
Wohlers, D ............................................. 2086<br />
Wohlers, D W .......................................... 399<br />
Wojke, M ...................................................114<br />
Wolansky, M J ............................2161*, 2162<br />
Wolf, A ........................................1863*, 2010<br />
Wolf, C J ................................................1224*<br />
Wolf, D ..................................................... 672<br />
Wolf, D C .........................1816, 1819, 2144*,<br />
.......................... 2146, 2147, 2148, 2149, 2150<br />
Wolf, K K ..................................................65*<br />
Wolfe, K ................................................2236*<br />
Wolfe, K J ............................................... 1274<br />
Wollenberg, M ........................................ 153<br />
Wollenberg, M L ................................... 1329<br />
Wolterbeek, A P ...................................... 953<br />
Wolz, E ................................................... 1429<br />
Wong, A W ...........................................1077*<br />
Wong, B A ...........................699*, 1463, 1467<br />
Wong, C ................................................... 739
AUTHOR INDEX<br />
Author Index (Continued)<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Wong, C K ......................................... 96, 553<br />
Wong, D ................................................... 407<br />
Wong, D F ................................................ 678<br />
Wong, J S .................................................... 59<br />
Wong, M H ........................................ 96, 553<br />
Wong, P .................................................1753*<br />
Wong, S S ................................................936*<br />
Wong, V A ............................................... 940<br />
Woo, E .................................................... 1427<br />
Wood, B .................................................... 187<br />
Wood, C ......................................... 680, 1743<br />
Wood, C R .............................................. 2150<br />
Wood, C S ...................................1478*, 1479<br />
Wood, S G .................................................. 65<br />
Wood, T .................................................. 1076<br />
Woodall, G M .............................2088, 2093*<br />
Woodrow, J E ......................................... 1009<br />
Woods, C G ............................................759*<br />
Woods, J S ............................ 184, 1216, 1275<br />
Woodstock, A D ...................................... 232<br />
Woodward, L ........................................ 1289<br />
Woolhiser, M ......................................... 1307<br />
Worden, R M ......................................... 1938<br />
Working Group, I ........................... 261, 386<br />
Wormser, U .....................................779, 784*<br />
Wortelboer, H ........................................ 1560<br />
Wragg, M ..............................................2192*<br />
Wright, J ..................................................1511<br />
Wright, J A ............................................. 1638<br />
Wright, L K ...........................................1072*<br />
Wright, L L ............................................1022*<br />
Wright, T ...........................1259*, 1284, 1285<br />
Wrighton, S A .................................... 65, 137<br />
Wu, F .......................................................243*<br />
Wu, H ........................ 233, 1150, 1558, 1629*<br />
Wu, J ............................................... 843, 1089<br />
Wu, R ...................................................... 1226<br />
Wu, R .....................................................1805*<br />
Wu, W ................................................... 1169*<br />
Wullenweber, A ...................................... 379<br />
Wyde, M E ....................................... 33, 1506<br />
X<br />
Xi, G ........................................................ 1528<br />
Xia, Q ...................................................... 2218<br />
Xia, X R .......................................2194, 2196*<br />
Xia, Y .......................................................... 99<br />
Xia, Z ............................................ 1541, 1959<br />
Xiao, R ...................................................... 274<br />
Xiao, S ...................................................2286*<br />
Xie, H .......................................... 1134*, 1594<br />
Xie, J ............................................1042, 1607*<br />
Xie, L .....................................................1725*<br />
Xie, R .......................................................823*<br />
Xie, W ....................................................... 721<br />
Xie, Y .......................................136, 138*, 144<br />
Xu, F ............................................. 1822, 2063<br />
Xu, J .......................................................2266*<br />
Xu, X ..............................................689, 1830*<br />
Xu, Y ..................................1203, 2189, 2228*<br />
Xu, Z A ..............................1098*, 1099, 1702<br />
Xu, S ......................................................1065*<br />
Xue, W .................................................... 1512<br />
Xue-Qing, C ...........................................1159<br />
Y<br />
Yabe, K ..................................................... 267<br />
Yabushita, S ............................................. 980<br />
Yaeger, M ............................................... 1385<br />
Yager, J D ............................1263, 1272, 1811<br />
Yakabe, Y ............................................... 1727<br />
Yaksh, T L ...............................................1103<br />
Yalowich, J ............................................. 2296<br />
Yamada, H ..................................... 531, 1899<br />
Yamada, J ............................................... 1784<br />
Yamada, T ................................... 834*, 1730*<br />
Yamamoto, M ........... 816, 1164*, 1833, 1861<br />
Yamamoto, T ............ 129, 531, 1899*, 1904*<br />
Yamamoto, Y ........................................... 267<br />
Yamanaka, T .......................................... 1376<br />
Yamasaki, K ........................................... 1727<br />
Yamauchi, H ............................................ 604<br />
Yamazaki, Y ..........................................2067*<br />
Yamoto, T ............................................... 1433<br />
Yan, S .......................................................483*<br />
Yan, X ....................................................... 960<br />
Yang, C ................................................... 2204<br />
Yang, D ..................................................1084*<br />
Yang, J .........................................2040*, 2181<br />
Yang, M ....................................... 256*, 2281*<br />
Yang, M S ....................................1600, 1601*<br />
Yang, R ........................................... 849, 1306<br />
Yang, R S ...............................377*, 865, 1300<br />
Yang, S Y .................................................. 202<br />
Yang, W .........................................723, 2170*<br />
Yang, X ............................................119, 2274<br />
Yang, Y ...........113, 647*, 1526, 1832*, 1832*<br />
Yang, Z ................................................... 1010<br />
Yano, B L .................................................. 282<br />
Yarberry, B ..................................... 274, 1737<br />
Yarberry, B N ............................................. 74<br />
Yashiro, C ................................................ 459<br />
Yasmeen, R .............................................622*<br />
Yasmin, T ............................................... 1414<br />
Yasuda, K ................................................... 65<br />
Yatsc<strong>of</strong>f, R W ......................................... 1255<br />
Yavanhxay, S ........................................1738*<br />
Yazzie, M ................................................. 157<br />
Ye, J ......................................................... 1634<br />
Ye, W ...................................................... 1847<br />
Ye, Y .......................................................2292*<br />
Yea, S .....................................................1261*<br />
Yeager, R L ............................................2245*<br />
Yeatts, J L ....................................2175*, 2194<br />
Yeatts, S .................................................. 1934<br />
Yee, N ....................................................... 968<br />
Yee, S ........................................................ 923<br />
Yee, S F ........................................1517*, 2229<br />
Yeh, J Z ......................................... 1962, 1963<br />
Yeow, A .................................................... 155<br />
Yeung, H Y .............................................. 553<br />
Yieh, L .............................................. 569, 755<br />
Yim, S H ................................................. 1704<br />
Yin, S ...................................................... 1301<br />
Yin, X ...............................................507*, 894<br />
Yin, X J ...................................................... 212<br />
Yokel, R A ........................1124, 1125*, 1660*<br />
Yokohira, M ..........................................1471*<br />
Yokoi, C .................................................. 2142<br />
Yokota, H ................................................. 267<br />
Yonamine, H ........................................... 834<br />
Yonemoto, J ........................................... 2142<br />
Yoneyama, K ................................1192, 1193<br />
Yoo, J L ..................................................1585*<br />
Yoon, B ................................................... 1380<br />
Yoon, L ................................................. 57, 59<br />
Yoon, M .................................................1917*<br />
Yoon, T ....................................................... 41<br />
Yoon, Y ................................................... 1215<br />
York, M J ...............................................6, 26*<br />
Yoshida, K ..............................................1611<br />
Yoshida, M ..............................................605*<br />
Yoshida, T ................................................ 604<br />
Yoshida, Y ........................... 1192, 1193, 1194<br />
Yoshihara, S ........................................... 1615<br />
Yoshikawa, N ........................................ 1501<br />
Yoshikawa, T ........................................1094*<br />
Yoshikuni, Y .......................................... 1379<br />
Yoshinaga, T ...................... 2064, 2067, 2068<br />
Yoshino, H ............................................... 746<br />
Yoshioka, T ...................................... 980, 981<br />
Yoshizawa, K ..............................1506*, 1821<br />
Yost, G S ................................. 304, 937, 1219<br />
Yost, L J .................................................. 1387<br />
You, L ..................................................... 1767<br />
You, S .....................................................1775*<br />
Young, J F ................................................ 293<br />
Young, R ...............................................1484*<br />
Young, S ........................................939*, 1449<br />
Yttri, K E .................................................. 417<br />
Yu, B ......................................................... 300<br />
Yu, C ......................................................... 332<br />
Yu, C K ......................................................96*<br />
Yu, I .......................................................1454*<br />
Yu, K ..................................................41*, 785<br />
Yu, K O ..................................................... 786<br />
Yu, L ........................................................1114<br />
Yu, L C .........................................1600*, 1601<br />
Yu, M ...................................................... 1014<br />
Yu, S ............................................................ 77<br />
Yu, T Z .....................................................107*<br />
Yu, W W ................................................. 2185<br />
Yu, X .................................. 1155*, 1655, 2257<br />
244<br />
Yu, Z ......................................................1499*<br />
Yuan, G .................................................... 537<br />
Yuan, W ................................................1564*<br />
Yuan, Y ........................................1059*, 1905<br />
Yuce, N ................................................... 1273<br />
Yunomae, K ............................................. 826<br />
Yvon, A ....................................................830*<br />
Z<br />
Zablotny, C L ........................................... 282<br />
Zacharewki, T R ................................... 1759<br />
Zacharewski, T ....................................1970*<br />
Zacharewski, T R ............................. 35, 101,<br />
............................................. 1363, 1382, 1383,<br />
.............................................. 1760, 1771, 1772<br />
Zacharias, W ........................................... 689<br />
Zacur, H ................................................... 422<br />
Zafar, K S ................................................... 47<br />
Zaffuto, K ...............................................894*<br />
Zager, M G ............................................1296*<br />
Zaharia, A ................................................ 218<br />
Zahnow, C A ..........................................1811<br />
Zairov, G B ............................................. 1040<br />
Zaja-Milatovic, S ..................................... 215<br />
Zajicek, J L ............................................. 1289<br />
Zakharyan, R A ............................. 153, 1329<br />
Zalups, R K ................................. 1138, 1604*<br />
Zang, Y ..................................................1267*<br />
Zangar, R C .............................. 1002*, 1003*<br />
Zaroogian, G E ...................................... 1745<br />
Zavala, F .................................................. 879<br />
Zawada, M .............................................343*<br />
Zawia, N H ........................ 1062, 1063, 1532<br />
Zayed, J ......................................1127*, 1128*<br />
Zeevalk, G ............................................. 1965<br />
Zeiger, E ................................................... 398<br />
Zeise, L ........................................... 396, 1521<br />
Zelcer, N ................................................ 1051<br />
Zelik<strong>of</strong>f, J ................................................... 18<br />
Zelik<strong>of</strong>f, J T ..................... 22*, 880, 881, 893*<br />
Zeng, Y ................................................... 1471<br />
Zenick, H ............................................... 1291<br />
Zepeda-Rodriguez, A ............................ 608<br />
Zerouala, C A ........................................ 1935<br />
Zervos, P ................................................ 1386<br />
Zewdie, T ..............................................2106*<br />
Zhang, F ............................1041, 1563, 1767*<br />
Zhang, G G ............................................ 1556<br />
Zhang, H .................................................. 658<br />
Zhang, J .....................263, 1513, 1554, 1842*<br />
Zhang, J G ................................................ 719<br />
Zhang, L ....................723, 1301, 1567, 2124*<br />
Zhang, Q ...................... 344, 723, 1567, 2071<br />
Zhang, W ............................................... 2124<br />
Zhang, X ..............................414, 415, 1279*,<br />
................................. 1543*, 1572, 2150, 2262*<br />
Zhang, Y .................................................. 288<br />
Zhang, Z ................................................ 1969<br />
Zhang, l .................................................2279*<br />
Zhao, B ............................................. 106, 353<br />
Zhao, H W ............................................... 212<br />
Zhao, J ...........................................748*, 1934<br />
Zhao, J Q .................................................. 847<br />
Zhao, M .......................64, 1005, 1900, 2056*<br />
Zhao, Q .................................................. 2294<br />
Zhao, Q J ...............................................2094*<br />
Zhao, S ................................................... 1267<br />
Zhao, X ........................................1962, 1963*<br />
Zhao, Y ................................... 574, 941, 1603<br />
Zheng, J ...............................228, 1564, 1571*<br />
Zheng, N ....................................... 376, 1126*<br />
Zheng, Q .................................896, 897, 900*<br />
Zheng, W ........................ 590, 591, 593, 594,<br />
....................... 1533, 1534, 1624, 1659*, 1663*<br />
Zheng, X ............................................... 1161*<br />
Zheng, X H ...................................... 146, 147<br />
Zheng, Y ........................................... 344, 614<br />
Zhong, C ...............................................1221*<br />
Zhong, Z ...............................................2133*<br />
Zhou, G ...................... 524, 1290, 1593, 2270<br />
Zhou, J .................................... 64, 1005, 1900<br />
Zhou, T ................................................... 119*<br />
Zhou, Y ............................... 119, 1124*, 1221<br />
Zhu, H .......................748, 1827, 1833, 1834*<br />
Zhu, S ....................................................1280*<br />
Zhu, Y ......................................................1129<br />
Zhuo, X .................................................... 723<br />
Ziccardi, M .............................................. 106<br />
Zieziulewicz, T ....................................... 196<br />
Zieziulewicz, T J ..................................... 189<br />
Zijverden van, M .................................... 953<br />
Zimmerman, A J ..................................... 576<br />
Zimmerman, K ............................... 161, 884<br />
Zimniak, P ............................................. 2217<br />
Zodrow, J M .......................................... 2242<br />
Zoeller, R ............................ 1086, 1741, 1775<br />
Zou, M ................................................... 2294<br />
Zuang, V .......................................... 664, 665<br />
Zuch, C L ................................................804*<br />
Zuckerman, L A ...................................... 800<br />
Zuehlke, U ............................................. 2025<br />
Zuscik, M ................................................. 695<br />
Zwick, L ................................................. 1916<br />
SOT's 44 th Annual Meeting
SOT Affiliates for 2005<br />
44 th Annual Meeting<br />
and ToxExpo<br />
(James E. Klaunig, Council Liaison)<br />
Abbott Laboratories<br />
Abbott Park, Illinois<br />
Chlorine Chemistry Council<br />
Arlington, Virginia<br />
H<strong>of</strong>fmann-La Roche, Inc.<br />
Nutley, New Jersey<br />
Agilent Technologies<br />
Wilmington, Delaware<br />
Alcon Research, Ltd.<br />
Fort Worth, Texas<br />
CIIT Centers for Health Research<br />
Research Triangle Park, North Carolina<br />
Coca-Cola Company<br />
Atlanta, Georgia<br />
Honeywell International, Inc.<br />
Morristown, New Jersey<br />
Johnson & Johnson Corporation<br />
New Brunswick, New Jersey<br />
REFERENCE<br />
American Chemistry Council<br />
Arlington, Virginia<br />
ANI LYTICS, INC.<br />
Gaithersburg, Maryland<br />
AstraZeneca R&D<br />
Södertälje, Sweden<br />
BAS Evansville<br />
Mount Vernon, Indiana<br />
Bayer<br />
Stilwell, Kansas<br />
Berlex Laboratories, Inc.<br />
Montville, New Jersey<br />
Biogen Idec<br />
Cambridge, Massachusetts<br />
Boehringer Ingelheim<br />
Pharmaceuticals, Inc.<br />
Ridgefield, Connecticut<br />
Bristol Myers Squibb Company<br />
New Brunswick, New Jersey<br />
CANTOX<br />
Mississauga, Ontario<br />
Charles River Laboratories<br />
Wilmington, Massachusetts<br />
Chevron Phillips Chemical<br />
Company LP<br />
The Woodlands, Texas<br />
ChevronTexaco Energy Research &<br />
Technology Company<br />
Richmond, California<br />
Colgate Palmolive Company<br />
Piscataway, New Jersey<br />
Covance Laboratories, Inc.<br />
Madison, Wisconsin<br />
Dial Corporation<br />
Scottsdale, Arizona<br />
Dow Chemical Company<br />
Midland, Michigan<br />
Dow Corning Corporation<br />
Midland, Michigan<br />
E. I. Du Pont de Nemours & Co.<br />
Newark, Delaware<br />
Eastman Chemical Company<br />
Kingsport, Tennessee<br />
Eastman Kodak Company<br />
Rochester, New York<br />
Eli Lilly & Company<br />
Indianapolis, Indiana<br />
ExxonMobil Biomedical Sciences Inc<br />
Annandale, New Jersey<br />
Genentech<br />
South San Francisco, California<br />
Gillette Company<br />
Needham, Massachusetts<br />
GlaxoSmithkline<br />
King <strong>of</strong> Prussia, Pennsylvania<br />
Johnson & Johnson<br />
Pharmaceutical R & D<br />
Raritan, New Jersey<br />
McNeil Consumer Healthcare<br />
Fort Washington, Pennsylvania<br />
Millennium Pharmaceuticals, Inc.<br />
Cambridge, Massachusetts<br />
Novartis Pharmaceuticals<br />
Corporation<br />
East Hanover, New Jersey<br />
Pfizer, Inc.<br />
New London, Connecticut<br />
Procter & Gamble Company<br />
Cincinnati, Ohio<br />
Sankyo Company, Ltd.<br />
Shizuoka, Japan<br />
San<strong>of</strong>i-Aventis<br />
Malvern, Pennsylvania<br />
Schering Plough Research Institute<br />
Kenilworth, New Jersey<br />
Sequani Limited<br />
Ledbury, Herefordshire<br />
Southern Research Institute<br />
Birmingham, Alabama<br />
WIL Research Laboratories, Inc.<br />
Ashland, Ohio<br />
Wyeth Ayerst Research<br />
Chazy, New York<br />
up-to-date information at www.toxicology.org 245
2004–2005 Council<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Linda S. Birnbaum Kendall B. Wallace James A. Popp<br />
REFERENCE<br />
President<br />
Vice President<br />
Vice President-elect<br />
• Board <strong>of</strong> Publications,<br />
Member, Liaison<br />
• Finance Committee,<br />
Member<br />
• IUTOX Councilor<br />
• Finance Committee,<br />
Member<br />
• IUTOX Councilor<br />
• <strong>Program</strong> Committee<br />
Chairperson, Liaison<br />
• Board <strong>of</strong> Publications,<br />
Auditor<br />
• Nominating Committee,<br />
Liaison<br />
• <strong>Program</strong> Committee,<br />
Co-Chairperson<br />
James E. Klaunig<br />
Norbert E. Kaminski<br />
Gary P. Carlson<br />
Treasurer Treasurer-elect Secretary<br />
• Council Subcommittee for<br />
Non-SOT and<br />
Contemporary Concepts in<br />
<strong>Toxicology</strong> (CCT) Meetings,<br />
Member<br />
• Exhibits Committee, Liaison<br />
• Finance Committee,<br />
Chairperson, Liaison<br />
• SOT Affiliates, Liaison<br />
• Council Subcommittee for<br />
Regional Chapter Funding,<br />
Member<br />
• Finance Committee,<br />
Member<br />
• Task Force for NIH<br />
Funding, Liaison<br />
• World Wide Web Advisory<br />
Committee, Liaison<br />
• Communique, Editor<br />
• Council Subcommittee for<br />
Regional Chapter Funding,<br />
Member<br />
• Historian, Liaison<br />
• Regulatory Affairs and<br />
Legislative Assistance<br />
Committee, Liaison<br />
246<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
2004–2005 Council (Continued)<br />
Marion F. Ehrich<br />
Ann de Peyster<br />
Yvonne P. Dragan<br />
Past President<br />
Councilor<br />
Councilor<br />
REFERENCE<br />
• Animals in Research<br />
Committee (AIR), Liaison<br />
• Awards Committee, Liaison<br />
• IUTOX Councilors, Liaison<br />
• Liaison Task Force, Liaison<br />
• Student Advisory<br />
Committee (SAC), Liaison<br />
• Communications Task<br />
Force, Liaison<br />
• Council Subcommittee for<br />
Regional Chapter Funding,<br />
Chairperson, Liaison<br />
• Education Subcommittee for<br />
K–12 Education, Liaison<br />
• Regional Chapters, Liaison<br />
• Continuing Education<br />
Committee, Liaison<br />
• Education Committee,<br />
Liaison<br />
Elaine M. Faustman<br />
Jose E. Manautou<br />
Shawn Douglas Lamb<br />
Councilor Councilor Executive Director<br />
• Career Resource and<br />
Development Committee,<br />
Liaison<br />
• Council Subcommittee for<br />
Non-SOT and<br />
Contemporary Concepts in<br />
<strong>Toxicology</strong> (CCT) Meetings,<br />
Chairperson, Liaison<br />
• Membership Committee,<br />
Liaison<br />
• Council Subcommittee for<br />
Non-SOT and<br />
Contemporary Concepts in<br />
<strong>Toxicology</strong> (CCT) Meetings,<br />
Member<br />
• Education Subcommittee for<br />
Minority Initiatives, Liaison<br />
• Specialty Sections, Liaison<br />
• Task Force for NIH<br />
Funding, Co-Liaison<br />
• Board <strong>of</strong> Publications, Staff<br />
Liaison<br />
• Communications Task<br />
Force, Staff Liaison<br />
• Finance Committee, Staff<br />
Liaison<br />
• IUTOX Councilors, Staff<br />
Liaison<br />
• Nominating Committee,<br />
Staff Liaison<br />
up-to-date information at www.toxicology.org 247
Officers and Councilors<br />
44 th Annual Meeting<br />
and ToxExpo<br />
REFERENCE<br />
Linda S. Birnbaum<br />
President (2004–2005)<br />
T: (919) 541–2655<br />
F: (919) 541–4284<br />
birnbaum.linda@epa.gov<br />
Kendall B. Wallace<br />
Vice President (2004–2005)<br />
T: (218) 726–8899<br />
F: (218) 726–8014<br />
kwallace@d.umn.edu<br />
James A. Popp<br />
Vice President-elect (2004–2005)<br />
T: (914) 709–2456<br />
F: (914) 709–2516<br />
james.popp@pharma.com<br />
James E. Klaunig<br />
Treasurer (2003–2005)<br />
T: (317) 274–7824<br />
F: (317) 274–7787<br />
jklauni@iupui.edu<br />
Norbert E. Kaminski<br />
Treasurer-elect (2004–2005)<br />
T: (517) 353–3786<br />
F: (517) 432–3218<br />
kamins11@msu.edu<br />
Gary P. Carlson<br />
Secretary (2004–2004)<br />
T: (765) 494–1412<br />
F: (765) 494–1414<br />
gcarlson@purdue.edu<br />
Marion F. Ehrich<br />
Past President (2004–2005)<br />
T: (540) 231–4938<br />
F: (540) 231–6033<br />
marion@vt.edu<br />
Ann de Peyster<br />
Councilor (2003–2005)<br />
T: (619) 594–3690<br />
F: (619) 594–6112<br />
adepeyst@mail.sdsu.edu<br />
Yvonne P. Dragan<br />
Councilor (2004–2006)<br />
T: (870) 543–7689<br />
F: (870) 543–7576<br />
ydragan@nctr.fda.gov<br />
Elaine M. Faustman<br />
Councilor (2004–2006)<br />
T: (206) 685-2269<br />
F: (206) 685-4696<br />
faustman@u.washington.edu<br />
Jose E. Manautou<br />
Councilor (2003–2005)<br />
T: (860) 486-3852<br />
F: (860) 486-4998<br />
manautou@uconnvm.uconn.edu<br />
Past Presidents<br />
1961–1962 Harold C. Hodge*<br />
1976–1977 Robert A. Scala<br />
1991–1992 Donald J. Reed<br />
1962–1963 C. Boyd Shaffer<br />
1977–1978 Harold M. Peck<br />
1992–1993 John L. Emmerson<br />
1963–1964 Paul S. Larson*<br />
1978–1979 Leon Golberg*<br />
1993–1994 I.Glenn Sipes<br />
1964–1965 Harry W. Hays*<br />
1979–1980 Tom S. Miya<br />
1994–1995 Meryl H. Karol<br />
1965–1966 Frederick Coulston*<br />
1980–1981 Perry J. Gehring*<br />
1995–1996 Jack H. Dean<br />
1966–1967 Verald K. Rowe*<br />
1981–1982 Robert B. Forney*<br />
1996–1997 James S. Bus<br />
1967–1968 John A. Zapp, Jr.*<br />
1982–1983 Robert L. Dixon*<br />
1997–1998 R. Michael McClain<br />
1968–1969 Carrol S. Weil*<br />
1983–1984 Gabriel L. Plaa<br />
1998–1999 Steven D. Cohen<br />
1969–1970 Ted A. Loomis<br />
1984–1985 Frederick W. Oehme<br />
1999–2000 Jay I. Goodman<br />
1970–1971 Robert L. Roudabush*<br />
1985–1986 Emil A. Pfitzer<br />
2000–2001 Daniel Acosta, Jr.<br />
1971–1972 Wayland J. Hayes, Jr.*<br />
1986–1987 John Doull<br />
2001–2002 David L. Eaton<br />
1972–1973 Victor A. Drill*<br />
1987–1988 Jerry B. Hook<br />
2002–2003 William F. Greenlee<br />
1973–1974 Joseph F. Borzelleca<br />
1988–1989 James E. Gibson<br />
2003–2004 Marion F. Ehrich<br />
1974–1975 Sheldon D.Murphy*<br />
1989–1990 Roger O. McClellan<br />
1975–1976 Seymour L. Friess<br />
1990–1991 Curtis D. Klaassen<br />
*Deceased<br />
248<br />
SOT's 44 th Annual Meeting
Headquarters Staff<br />
44 th Annual Meeting<br />
and ToxExpo<br />
Staff Contact Extension E-Mail Activity<br />
Shawn Douglas Lamb Extension 1444 shawnl@toxicology.org Executive Director<br />
Clarissa Russell Wilson Extension 1455 clarissa@toxicology.org Deputy Executive Director<br />
Rosibel Alvarenga Extension 1432 rosibel@toxicology.org Membership<br />
Jessica Canning Extension 1443 jessica@toxicology.org Administration<br />
Mia Delaney Extension 1440 mia@toxicology.org Accounting<br />
REFERENCE<br />
Betty Eidemiller Extension 1430 bettye@toxicology.org Animals in Research<br />
Education <strong>Program</strong>s<br />
Student Advisory Committee<br />
Student Awards<br />
Veronica Fisher Extension 1450 vfisher@toxicology.org Accounting<br />
Libby Jones Extension 1454 libby@toxicology.org Exhibits<br />
Michele Layton Extension 1423 michelel@toxicology.org Administration<br />
Tonia Masson Extension 1433 tonia@toxicology.org Administration<br />
Deborah O’Keefe Extension 1441 debbie@toxicology.org Publications<br />
World Wide Web<br />
Sue Pitsch Extension 1442 sue@toxicology.org Publications<br />
World Wide Web<br />
Membership<br />
Heidi Prange Extension 1424 heidi@toxicology.org Meetings<br />
Lilly Richards Extension 1454 lilly@toxicology.org Media<br />
Becca Rhame Extension 1447 becca@toxicology.org Administration<br />
Rita Rose Extension 1434 rita@toxicology.org Historian<br />
Regional Chapters<br />
Registration<br />
Specialty Sections<br />
Nichelle Sankey Extension 1431 nichelle@toxicology.org <strong>Program</strong> Committee<br />
Career Resource and Development<br />
Continuing Education<br />
Elisa Turner Extension 1445 elisa@toxicology.org Publications<br />
World Wide Web<br />
Karen Wareham Extension 1446 karen@toxicology.org Administration<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Headquarters<br />
1821 Michael Faraday Drive, Suite 300, Reston, Virgina 20190<br />
Tel: (703) 438–3115; Fax: (703) 438-3113<br />
E-Mail: sothq@toxicology.org; Web site: www.toxicology.org<br />
up-to-date information at www.toxicology.org 249
Elected Committees<br />
44 th Annual Meeting<br />
and ToxExpo<br />
REFERENCE<br />
Awards<br />
(Marion F. Ehrich*)<br />
Deborah A. Cory-Slecta, Chairperson (2004–2005)<br />
Member (2004–2006)<br />
Kim Boekelheide (2004–2006)<br />
Annie M. Jarabek (2004–2006)<br />
Stephen H. Safe (2003–2005)<br />
Bernard A. Schwetz (2003–2005)<br />
(Shawn D. Lamb**)<br />
Education<br />
(Yvonne P. Dragan*)<br />
Judith T. Zelik<strong>of</strong>f, Chairperson (2004–2005),<br />
Member (2002–2005)<br />
Darlene Dixon (2002–2005)<br />
Michelle J. Hooth (2004–2007)<br />
B. Paige Lawrence (2004–2007)<br />
Mark J. Reasor (2003–2006)<br />
Rosita Rodriguez Proteau (2003–2006)<br />
Wendy N. Jefferson, Student Representative<br />
ad hoc (2004–2005)<br />
(Betty Eidemiller**)<br />
Membership<br />
(Elaine M. Faustman*)<br />
William Slikker, Jr., Chairperson (2004–2005)<br />
Member (2003–2006)<br />
Jeanine L. Bussiere (2004–2007)<br />
Rory B. Conolly (2002–2005)<br />
Jack R. Harkema (2004–2007)<br />
Alvaro Puga (2003–2006)<br />
Denise E. Robinson (2002–2005)<br />
Castle J. Funatake, Student Representative<br />
ad hoc (2004–2005)<br />
(Sue Pitsch**)<br />
Nominating<br />
(James A. Popp*)<br />
William F. Greenlee, Chairperson (2004–2005),<br />
Member (2004–2005)<br />
Daniel Acosta, Jr. (2004–2005)<br />
Matthew S. Bogdanffy (2004–2006)<br />
Myrtle A. Davis (2004–2006)<br />
Peter L. Goering (2004–2005)<br />
(Shawn D. Lamb**)<br />
Appointed Committees<br />
Animals in Research (AIR)<br />
(Marion F. Ehrich*)<br />
Stephen M. Lasley, Chairperson (2004–2005),<br />
Member (2002–2005)<br />
Charles C. Barton (2002–2005)<br />
Brian R. Marable (2003–2006)<br />
Rebecca Rice (2003–2006)<br />
Harihara M. Mehendale (2004–2007)<br />
Jan Oberdoerster (2004–2007)<br />
Christina Wilson, Student Representative ad hoc (2004–2005)<br />
(Betty Eidemiller**)<br />
Board <strong>of</strong> Publications (BOP)<br />
Linda S. Birnbaum*, President, Member (2004–2005)<br />
Richard E. Peterson, Chairperson (2003–2005),<br />
Member (2001–2005)<br />
Brian J. Day (2002–2006)<br />
William R. Kelce (2004–2008)<br />
Lois D. Lehman-McKeeman, ToxSci Editor, Auditor<br />
Nancy Ann Monteiro-Riviere (2003–2007)<br />
James A. Popp, Auditor (2004–2005)<br />
(Shawn D. Lamb**)<br />
* Council Liaison<br />
** Staff Liaison<br />
250<br />
Career Resource and Development Committee<br />
(Elaine M. Faustman*)<br />
Tracy M. Williams, Chairperson (2004–2005),<br />
Member (2002–2005)<br />
Yolanda Banks Anderson (2003–2006)<br />
Michel Charbonneau (2003–2006)<br />
Charles D. Hebert (2004–2007)<br />
Julia S. Kimbell (2003–2006)<br />
Willie J. McKinney (2004–2007)<br />
Virginia C. Moser (2004–2007)<br />
Mitzi Nagarkatti (2002–2005)<br />
William A. Toscano (2002–2005)<br />
Jonathan M. Maher, Student Representative<br />
ad hoc (2004–2005)<br />
(Nichelle Sankey**)<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Appointed Committees (Continued)<br />
Continuing Education (CE)<br />
(Yvonne P. Dragan*)<br />
Betty Ann Pettersen, Chairperson (2004–2005),<br />
Member (2002–2005)<br />
Laurie Couture Haws (2004–2007)<br />
Mary Jane Cunningham (2001–2005)<br />
Braulio D. Jimenez-Velez (2004–2007)<br />
Douglas Alan Keller (2003–2006)<br />
Jeffrey Maurice Peters (2003–2006)<br />
Jack P. Vanden Heuvel (2002–2005)<br />
Douglas C. Wolf (2004–2007)<br />
Jennifer Orme Zavaleta (2003–2006)<br />
Andrew Annalora, Student Representative ad hoc (2004–2005)<br />
(Nichelle Sankey**)<br />
Finance<br />
James E. Klaunig*, Treasurer, Chairperson (2003–2005)<br />
Linda S. Birnbaum, President, Member (2004–2005)<br />
Matthew S. Bogdanffy (2002–2005)<br />
William J. Brock (2004–2007)<br />
Erik Dybing (2003–2006)<br />
Norbert E. Kaminski, Treasurer-elect,<br />
Member (2004–2005)<br />
Kendall B. Wallace, Vice President, Member (2004–2005)<br />
(Shawn D. Lamb**)<br />
Historian<br />
(Gary P. Carlson*)<br />
Ernest Hodgson, Chairperson (2004–2005)<br />
(Rita Rose**)<br />
IUTOX Councilors<br />
Marion F. Ehrich*, Member (2004–2007)<br />
Daniel Acosta, Jr. (2004–2007)<br />
Linda S. Birnbaum (2004–2007)<br />
George B. Corcoran (2004–2007)<br />
Kendall B. Wallace (2004–2007)<br />
(Shawn D. Lamb**)<br />
<strong>Program</strong><br />
Kendall B. Wallace*, Vice President,<br />
Chairperson (2004–2005)<br />
James A. Popp, Vice President-Elect, Co-Chairperson<br />
(2004–2005)<br />
Barbara D. Beck (2002–2005)<br />
Rakesh Dixit (2002–2005)<br />
Lori A. Dostal (2003–2006)<br />
Michael R. Franklin (2004–2007)<br />
Dori R. Germolec (2003–2006)<br />
Terry Gordon (2003–2005)<br />
Bruce J. Kelman (2004–2007)<br />
Thomas W. Kensler (2002–2005)<br />
Kannan Krishnan (2003–2006)<br />
Gary H. Perdew (2003–2006)<br />
Larry P. Sheets (2003–2005)<br />
Martin Vandenberg (2004–2007)<br />
Philip J. Bushnell (2004–2007)<br />
(Nichelle Sankey**)<br />
Regulatory Affairs and Legislative Assistance<br />
Committee (RALA)<br />
(Gary P. Carlson*)<br />
Peter L. Goering, Chairperson (2004–2005),<br />
Member (2003–2006)<br />
Kulbir S. Bakshi (2003–2006)<br />
Mike Bolger (2004–2007)<br />
Janis E. Hulla (2002–2005)<br />
Leslie J. Hushka (2002–2005)<br />
RuthAnn Rudel (2004–2007)<br />
Melinda Pomeroy, Student Representative ad hoc (2004–2005)<br />
(Clarissa Russell Wilson**)<br />
REFERENCE<br />
* Council Liaison<br />
** Staff Liaison<br />
up-to-date information at www.toxicology.org 251
44 th Annual Meeting<br />
and ToxExpo<br />
Appointed Committees (Continued)<br />
REFERENCE<br />
Student Advisory Committee (SAC)<br />
(Marion Ehrich*)<br />
Christina Wilson, Chairperson, Animals in Research<br />
Tracy Pickering, Co-Chairperson (Michigan)<br />
Jessica E. Duffy, Secretary (Mid-Atlantic)<br />
Andrew Annalora (Mountain West), Continuing Education<br />
Jessica Berthiaume (Northland)<br />
Cary Coburn, Southern California<br />
Castle Funatake (Pacific Northwest), Membership<br />
Wendy N. Jefferson (North Carolina), Education<br />
Tisha King-Deiden (Midwest)<br />
Joseph P. Lynch (Northeast), WWWAC, K–12 SC<br />
Jonathan M. Maher (Central States), Career Resource and<br />
Development Committee<br />
Ashley R. Murray (Allegheny-Erie), WIT<br />
Melinda Pomeroy-Black (National Capital), RALA<br />
Karen Riveles (Southern California), Specialty Sections<br />
Sharmilee Sawant (South Central), Specialty Sections<br />
Vince Seaman (Northern California)<br />
Yang Ye (Gulf Coast)<br />
Lonnie D. Williams (Southeastern)<br />
Yu Zang (Ohio Valley), SCMI<br />
John Norman (Lake Ontario)<br />
(Betty Eidemiller**)<br />
World Wide Web Advisory Committee<br />
(WWWAC)<br />
(Norbert E. Kaminski*)<br />
Michael L. Dourson, Chairperson (2004–2005),<br />
Member (2003–2006)<br />
Christpher P. Chengelis (2004–2007)<br />
Howard Perry Glauert (2004–2007)<br />
James P. Kehrer (2001–2005)<br />
Allan R. Parrish (2002–2005)<br />
Ruth A. Roberts (2003–2006)<br />
Joseph P. Lynch, Student Representative ad hoc (2004–2005)<br />
(Deborah O’Keefe**)<br />
Council Subcommittee for Non-SOT Funding<br />
and Contemporary Concepts in <strong>Toxicology</strong><br />
(CCT) Meetings<br />
Elaine M. Faustman, Chairperson (2004–2005),<br />
Member (2004–2005)<br />
James E. Klaunig*, Member (2004–2005)<br />
Jose E. Manautou (2004–2005)<br />
(Rita Rose**)<br />
Council Subcommittee for Regional Chapter<br />
Funding<br />
Ann de Peyster*, Chairperson (2004–2005),<br />
Member (2003–2005)<br />
Gary P. Carlson (2003–2005)<br />
Norbert E. Kaminski (2004–2005)<br />
(Rita Rose**)<br />
Education Subcommittee for K–12 Education<br />
(Ann de Peyster*)<br />
Mark J. Reasor, Chairperson (2004–2005),<br />
Member (2003–2006)<br />
B. Paige Lawrence, Co-Chairperson (2004–2005),<br />
Member (2004–2007)<br />
David William Cragin (2002–2005)<br />
Darlene Dixon (2002–2005)<br />
Suzanne Fitzpatrick (2004–2006)<br />
Kenneth McMartin (2003–2006)<br />
Marion G. Miller (2002–2005)<br />
Joanne Zurlo (2002–2005)<br />
Elaine Knight, ad hoc (2003–2005)<br />
Carrie Markgraf, ad hoc (2004–2006)<br />
Liam O’Fallon, ad hoc (2004–2005)<br />
John Pierce Wise, ad hoc (2004–2005)<br />
Judith T. Zelik<strong>of</strong>f, ad hoc (2004–2005)<br />
Joseph P. Lynch, Student Representative ad hoc (2004–2005)<br />
(Betty Eidemiller**)<br />
Education Subcommittee for Minority Initiatives<br />
(Jose E. Manautou*)<br />
Rosita Rodriguez Proteau, Chairperson (2004–2005),<br />
Member (2003–2006)<br />
Michelle Hooth, Co-Chairperson (2004–2005),<br />
Member (2004–2007)<br />
Marquea D. King (2003–2006)<br />
Chudy I. Nduaka (2002–2005)<br />
Peter T. Thomas (2003–2006)<br />
Alice R. Villalobos (2002–2005)<br />
Charles Azuka, ad hoc (2004–2005)<br />
Vicente Santa Cruz, ad hoc (2004–2005)<br />
Myrtle A. Davis, ad hoc (2004–2005)<br />
Heather Kleiner, ad hoc (2004–2005)<br />
Judith T. Zelik<strong>of</strong>f, ad hoc (2004–2005)<br />
Yu Zang, Student Representative ad hoc (2004–2005)<br />
(Betty Eidemiller**)<br />
* Council Liaison<br />
** Staff Liaison<br />
252<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
Officers—Specialty Sections<br />
Biological Modeling (79)*<br />
John M. Frazier, President<br />
Alan G.E. Wilson, Vice President<br />
Charles Timchalk, Vice President-elect<br />
Elaina Kenyon, Secretary/Treasurer<br />
Jeffrey W. Fisher (Past President), Torka S. Poet,<br />
and Lisa M. Sweeney, Councilors<br />
Carcinogenesis (197)<br />
Ruth A. Roberts, President<br />
John E. French, Vice President<br />
Michael L. Cunningham, Vice President-elect<br />
Kyle J. Kolaja, Secretary/Treasurer<br />
Jon C. Cook (Past President), Richard J. Bull,<br />
Michel Charbonneau, and Lisa M. Kamendulis,<br />
Councilors<br />
Leanne L. Berdard, Student Representative<br />
Comparative and<br />
Veterinary (82)<br />
William Valentine, President<br />
Myrtle Davis, Vice President<br />
Wilson Rumbeiha, Vice President-elect<br />
James Deyo, Secretary/Treasurer<br />
Stephen B. Hooser (Past President), Jay Albretsen<br />
and Charles Capen, Councilors<br />
Dermal <strong>Toxicology</strong> (97)<br />
Nancy A. Monteiro-Riviere, President<br />
Robert L. Bronaugh, Vice President<br />
James N. McDougal, Vice President-elect<br />
Cynthia A. Ryan, Secretary/Treasurer<br />
Ian Kimber (Past President), Carol S. Auletta, and<br />
Debra L. Laskin, Councilors<br />
Ethical, Legal, and Social Issues (New Section)<br />
Steven Gilbert, President<br />
Jacques Maurissen, Vice President<br />
Spencer R. Mortensen, Secretary/Treasurer<br />
TBE, (Past President), Bruce Kelman and Bernard<br />
Weiss, Councilor<br />
Drug Discovery <strong>Toxicology</strong><br />
(New Section)<br />
Ethical, Legal, and Social Issues<br />
(New Section)<br />
Steven Gilbert, President<br />
Jacques Maurissen, Vice President<br />
Spencer R. Mortensen, Secretary/Treasurer<br />
TBE, (Past President), Bruce Kelman and Bernard<br />
Weiss, Councilors<br />
Food Safety (104)<br />
Ronald T. Riley, President<br />
Bryan Delaney, Vice President<br />
George A. Burdock, Vice President-elect<br />
Kenneth A. Voss, Secretary/Treasurer<br />
Joel L. Mattsson (Past President), Michael Bolger,<br />
George E. Dunaif, Bruce G. Hammond, and<br />
Craig Llewellyn, Councilors<br />
Immunotoxicology (261)<br />
Robert Luebke, President<br />
Ken Hastings, Vice President<br />
Mitchel Cohen, Vice President-elect<br />
Steve Pruett, Secretary/Treasurer<br />
Thomas T. Kawabata (Past President), Jeanine<br />
Bussiere and Michael McCabe, Councilors<br />
Beatrice Seguin, Student Representative<br />
In Vitro (106)<br />
Julio C. Davila, President<br />
Sidney Green, Vice President<br />
George DeGeorge, Vice President-elect<br />
Peter T. Harvison, Secretary/Treasurer<br />
Bruce A. Fowler (Past President), Mark E. Blazka,<br />
Robert T. Dunn, Rosita Proteau, and Joan B.<br />
Tarl<strong>of</strong>f, Councilors<br />
Inhalation (191)<br />
Charles Plopper, President<br />
MaryJane Selgrade, Vice President<br />
Michael Foster, Vice President-elect<br />
Matthew Reed, Secretary/Treasurer<br />
Steve R. Kleeberger (Past President), Lung Chi<br />
Chen, Ian Gilmour, Ermila Kodavanti, and<br />
Michael Madden, Councilors<br />
Mechanisms (255)<br />
Serrine S. Lau, President<br />
Daniel C. Liebler, Vice President<br />
Kenneth S. Ramos, Vice President-elect<br />
Monica A. Valentonic, Secretary/Treasurer<br />
Robin S. Goldstein (Past President), Tiffany G.<br />
Bredfeldt, Dennis Peterson, and John H.<br />
Richburg, Councilors<br />
Metals (106)<br />
Maryka H. Bhattacharyya, President<br />
Donald R. Smith, Vice President<br />
Michael J. McCabe, Vice President-elect<br />
William E. Achanzar, Secretary/Treasurer<br />
Judith T. Zelik<strong>of</strong>f (Past President), Kirk T. Kitchin,<br />
and Toby G. Rossman, Councilors<br />
Elena S. Craft, Student Representative<br />
Molecular Biology (137)<br />
Jack P. Vanden Heuvel, President<br />
Melissa A. Runge-Morris, Vice President<br />
Craig Marcus, Vice President-elect<br />
Elizabeth V. Wattenberg, Secretary/Treasurer<br />
William B. Mattes (Past President), Richard S.<br />
Pollenz and Thomas R. Sutter, Councilors<br />
Heather S. Floyd, Student Representative<br />
Neurotoxicology (219)<br />
Carey N. Pope, President<br />
Richard F. Seegal, Vice President<br />
Robert C. MacPhail, Vice President-elect<br />
Mary E. Gilbert, Secretary/Treasurer<br />
Stephanie Padilla (Past President), Stephen M.<br />
Lasley, and Lisa A. Opanashuk, Councilors<br />
up-to-date information at www.toxicology.org 253<br />
Occupational and Public<br />
Health (119)<br />
David A. Morgott, President<br />
Heather D. Burleigh-Flayer, Vice President<br />
Harold Zenick, Vice President-elect<br />
Marth M. Moore, Secretary/Treasurer<br />
Vincent Castranova (Past President), Bryan D.<br />
Hardin, and geary W. Olsen, Councilors<br />
Regulatory and Safety<br />
Evaluation (359)<br />
Ronald J. Gerson, President<br />
Ronald S. Slesinski, Vice President<br />
James T. MacGregor, Vice President-elect<br />
Frank D. Sistare, Secretary/Treasurer<br />
Carol S. Auletta (Past President) Andrea B. Weir<br />
and Vijayapal Reddy, Councilors<br />
Reproductive and<br />
Developmental (227)<br />
John M. Rogers, President<br />
Dana L. Shuey, Vice President<br />
Jerrold J. Heindel, Vice President-elect<br />
George L. Foley, Secretary/Treasurer<br />
Carole A. Kimmel (Past President), Kim<br />
Boekelheide and Eve Mylchreest, Councilors<br />
Risk Assessment (311)<br />
Annie M. Jarabek, President<br />
Kannan Krishnan, Vice President<br />
Michael L. Gargas, Vice President-elect<br />
Stephen M. DiZio, Secretary/Treasurer<br />
Edward V. Sargent (Past President), Deborah M.<br />
Proctor and Lorenz R. Rhomberg, Councilors<br />
Toxicologic and Exploratory<br />
Pathology (88)<br />
Brian G. Short, President<br />
Jack R. Harkema, Vice President<br />
Susan G. Emeigh Hart, Secretary/Treasurer<br />
Bruce McCullough (Past President), Thomas M.<br />
Monticello, and Gail L. Walter, Councilors<br />
Women in <strong>Toxicology</strong> (WIT)<br />
(141)<br />
Eva Oberdorster, President<br />
Mary Ellen Cosenza, Vice President<br />
Maryka H. Bhattacharyya, Secretary/Treasurer<br />
Virginia C. Moser (Past President),<br />
Janet M. Benson and Rita M. Turkall, Councilors<br />
Ashley R. Murray, Student Representative ad hoc<br />
REFERENCE
44 th Annual Meeting<br />
and ToxExpo<br />
Officers—Regional Chapters<br />
REFERENCE<br />
Allegheny-Erie<br />
Lawrence Milchak, President<br />
Mark Weisberg, Vice President<br />
Melanie Flint, Vice President-elect<br />
Robin Gandley, Secretary<br />
William McKay, Treasurer<br />
A. Phil Leber (Past President), Elaine L. Freeman<br />
and Jim Scabilloni, Councilors<br />
Ashley Murray, Student Representative<br />
Central States<br />
Sam Cohen, President<br />
Charles Barton, Vice President<br />
Lora Arnold, Secretary/Treasurer<br />
George Casale (Past President) Bill Berndt, Dianne<br />
Brit, Greg Reed, and Yvonne Wong, Councilors<br />
Jonathan Maher, Student Representative<br />
Gulf Coast<br />
David J. McConkey, President<br />
Susan Fischer, Vice President<br />
Bryan Brooks, Vice President-elect<br />
Mary F. Kanz, Treasurer<br />
Yunan Tian, Secretary<br />
Mary F. Kanz (Past President), Shawn B. Bratton<br />
and M. Firoze Khan, Councilors<br />
Danyel Tacker, Student Representative<br />
Lake Ontario<br />
TBE, President<br />
TBE, Vice President<br />
TBE, Treasurer/Secretary<br />
Harish C. Sikka (Past President), and TBE,<br />
Councilors<br />
Michigan<br />
Stephen W. Frantz, President<br />
James McKim, Vice President<br />
Paul Stemmer, Treasurer/Secretary<br />
Robert G. Meeks (Past President), Yvonne Frater,<br />
Paul A. Jean, and John J. LaPres Councilor<br />
Tracy Pickering, Student Representative<br />
Mid-Atlantic<br />
David W. Cragin, President<br />
Michael F. Kelley, Vice President<br />
Angelique Braen, Vice President-elect<br />
Diann L. Blanset, Secretary/Treasurer<br />
Peter J. Harvison (Past President), Anne<br />
Chappelle, Anthony R. Schatz, and Margaret<br />
A. Wojke, Councilors<br />
Jessica Duffy, Student Representative<br />
Midwest<br />
Bruce A. Trela, President<br />
Kevin Williams, President-elect<br />
Barbara Struthers, Secretary<br />
Linda L. Tam, Treasurer<br />
D. Reid Patterson (Past President), Bill Johnson,<br />
Chuck Mattis, Daniel E. McLain, and Susan L.<br />
Schantz, Councilors<br />
Tisha King-Deiden, Student Representative<br />
Mountain West<br />
Robert Clark Lantz, President<br />
Linda Quattrochi, Vice President<br />
Chris Reilly, Vice President-elect<br />
Nathan Cherrington, Secretary/Treasurer<br />
Mary Walker (Past President), Michael Franklin<br />
and Jim Lu, Councilors<br />
Andrew Annalora, Student Representative<br />
National Capital Area Chapter<br />
David Jacobson-Kram, President<br />
Harry Milman, Vice President<br />
Pamela L. Chamberlain, Secretary<br />
Laurie Roszell, Treasurer<br />
Sidney Green (Past President), Gary Burin, Lynn<br />
Flowers and Thomas Flynn, Councilors<br />
Melinda Pomeroy-Black, Student Representative<br />
Mashael Al-Namaeh, Student Vice Representative<br />
North Carolina<br />
Dave Dorman, President<br />
Michael Waalkes, Vice President<br />
Nigel J. Walker, Vice President-elect<br />
Elaina Kenyon, Secretary/Treasurer<br />
Louise M. Ball (Past President), Kevin Cr<strong>of</strong>ton and<br />
Michelle J. Hooth, Councilors<br />
Wendy Jefferson, Student Representative<br />
Northeast<br />
Jatinder Singh, President<br />
James Blank, President-elect<br />
TBE, Vice President<br />
Doug Bill, Secretary/Treasurer<br />
Charles Giardina (Past President), Brian<br />
Aneskievich, Councilors<br />
Joe Lynch, Student Representative<br />
Northern California<br />
Susan A. Rice, President<br />
Linval R. DePass, President-elect<br />
George V. Alexeeff, Vice President<br />
Sanjay Chanda, Secretary<br />
Carol E. Green, Treasurer<br />
Robert A. Howd (Past President), George R.<br />
Clemens and Kyle L. Kolaja, Councilors<br />
Vince Seaman, Student Representative<br />
Northland<br />
Elizabeth V. Wattenberg, President<br />
Thomas P. Brunshidle, Secretary/Treasurer<br />
Hilary Carpenter (Past President), Teri K. Fick, and<br />
Pamela J. Shubat, Councilors<br />
Jessica Barthiaume, Student Representative<br />
Ohio Valley<br />
Hollie I. Swanson, President<br />
James Kang, President-elect<br />
Charles V. Smith, Vice President<br />
Gavin E. Arteel, Secretary/Treasurer<br />
John C. Lipscomb (Past President), Gina Grossi,<br />
Jay Harriman, and Amy L. Roe, Councilors<br />
Janet Zang, Student Representative<br />
Pacific Northwest<br />
Peter S. Spencer, President<br />
Rosita Proteau, Vice President<br />
Andrij Holian, Vice President-elect<br />
Carin Thomas, Secretary/Treasurer<br />
Marc W. Fariss (Past President), David Shepherd,<br />
and Cecile Krejsa, Councilor<br />
Castle J. Funatake, Student Representative<br />
South Central<br />
Kenneth E. McMartin, President<br />
Sharon Meyer, Vice President<br />
Martin J. Ronis, Vice President-elect<br />
Tammy Dugas, Secretary<br />
Kristie Willett, Treasurer<br />
Deborah Hansen (Past President), Russell Carr and<br />
Heather Kleiner, Councilors<br />
Sharmilee Sawant, Student Representative<br />
Southeastern<br />
Essam Enan, President<br />
Carol Wood, Secretary/Treasurer<br />
James A. Deyo (Past President), Julie C<strong>of</strong>field and<br />
Markus Day, Councilors<br />
Lonnie Williams, Student Representative<br />
Southern California<br />
John Wisler, President<br />
Drew Badger, Vice President<br />
Julie Doerr-Stevens, Secretary<br />
Tina Leakakos, Treasurer<br />
Stacie L. Wild (Past President), Anthony Ndifor,<br />
Councilors<br />
Cary Coburn, Student Representative<br />
254<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards<br />
In recognition <strong>of</strong> distinguished toxicologists and students, SOT presents several prestigious awards each year. In addition to receiving the<br />
award stipend and plaque, recipients are honored at a special Awards Ceremony at the SOT Annual Meeting and their names are listed in SOT<br />
publications. The deadline for 2006 award nominations is October 9, 2005.<br />
The Awards Committee reviews applications for SOT Awards and Sponsored Awards for scientists. Nominations for most <strong>of</strong> these awards must be<br />
submitted by a sponsor and a seconder who are Full members <strong>of</strong> SOT using the On-Line Award Nomination Form. The supporting documentation<br />
must indicate the candidate’s achievements in toxicology and is critical in the review <strong>of</strong> each application. See the award description for the additional<br />
requirements for some <strong>of</strong> the awards, including the Sponsored Awards. The Best Paper Awards are reviewed by the Board <strong>of</strong> Publications.<br />
Student awards, both SOT and Sponsored awards, are reviewed by the Education Committee, and application procedures are specific for each award.<br />
Other student awards are available through Regional Chapters and Specialty Sections. A student may apply for any award for which he or she is<br />
eligible and may apply for and receive multiple awards, whether SOT, Regional Chapters, or Specialty Sections sponsor the awards. Policies related<br />
to travel awards are determined by the sponsor (SOT, Regional Chapter, or Specialty Section).<br />
REFERENCE<br />
Full descriptions <strong>of</strong> each award, application procedures, and names <strong>of</strong> past recipients may be found on the SOT Web site at www.toxicology.org.<br />
Award Descriptions<br />
Indicates an SOT Sponsored Award<br />
Achievement Award<br />
The Achievement Award is presented to a member <strong>of</strong> the<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> who has less than 15 years experience<br />
since obtaining his/her highest earned degree (in the year <strong>of</strong> the<br />
Annual Meeting <strong>of</strong> the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>) and who has made<br />
significant contributions to toxicology. This award consists <strong>of</strong> a<br />
plaque and a cash stipend.<br />
Award Recipients<br />
1967 ..................................................................... Gabriel L. Plaa<br />
1968 ................................................................. Allan H. Conney<br />
1969 ................................................................Samuel S. Epstein<br />
1970 ............................................................ Sheldon D. Murphy<br />
1971 ............................................................................Yves Alarie<br />
1972 ................................................................... Robert L. Dixon<br />
1973 .......................................................................... (No Award)<br />
1974 ...............................................................Morris F. Cranmer<br />
1975 ........................................................................Ian C. Munro<br />
1976 ...............................................................Curtis D. Klaassen<br />
1977 ...................................................................James E. Gibson<br />
1978 ....................................................... Raymond D. Harbison<br />
1979 .................................................................. Michael R. Boyd<br />
1980 ............................................................. Philip G. Watanabe<br />
1981 .......................................................................... (No Award)<br />
1982 ..................................................... Frederick P. Guengerich<br />
1983 .......................................................................... (No Award)<br />
1984 ............................................................ Melvin E. Andersen<br />
1985................................................................... Alan R. Buckpitt<br />
1986 ...........................................................................Sam Kacew<br />
1987 ......................................................................... James S. Bus<br />
1988 .............................................................. Jeanne M. Manson<br />
1989 ....................................................................James P. Kehrer<br />
1990 ..............................................................Michael P. Waalkes<br />
1991 ..............................................................Debra Lynn Laskin<br />
1992 .......................................................... Michael P. Holsapple<br />
1993 .....................................................................David L. Eaton<br />
1994 ..................................................................James L. Stevens<br />
1995 ..................................................................... Lucio G. Costa<br />
1996 ................................................................... Kenneth Ramos<br />
1997 ..................................................................Kevin E. Driscoll<br />
1998 ...........................................................Rick G. Schnellmann<br />
1999 .......................................................... Michel Charbonneau<br />
2000 ...........................................................Christpher Bradfield<br />
2001 .................................................................... Martin Philbert<br />
2002.......................................................................... Ruth Roberts<br />
2003................................................Lois D. Lehman-McKeeman<br />
2004.......................................................................David Dorman<br />
up-to-date information at www.toxicology.org 255
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
REFERENCE<br />
Arnold J. Lehman Award<br />
The Arnold J. Lehman Award is presented to recognize an individual<br />
who has made a major contribution to risk assessment<br />
and/or the regulation <strong>of</strong> chemical agents, including pharmaceuticals.<br />
The contribution may have resulted from the application<br />
<strong>of</strong> sound scientific principles to regulation and/or from research<br />
activities that have significantly influenced the regulatory process.<br />
The nominee may be employed in academia, government, or<br />
industry and must be a SOT member. This award consists <strong>of</strong> a<br />
plaque and a cash stipend.<br />
Award Recipients<br />
1980 ................................................................. Allan H. Conney<br />
1981 ..................................................................... Gabriel L. Plaa<br />
1982 ................................................................ Gary M. Williams<br />
1983 .........................................................................David P. Rall<br />
1984 ..........................................................................Tibor Balasz<br />
1985 ............................................................ Frederick Coulston*<br />
1986 .................................................. Gerrit Johannes Van Esch<br />
1987 ....................................................................John P. Frawley<br />
1988 ................................................................Kundan S. Khera*<br />
1989 .......................................................... Richard H. Adamson<br />
1990 ................................................................... Harold C. Grice<br />
1991 ........................................................... Bernard A. Schwetz<br />
1992 .............................................................Roger O. McClellan<br />
1993 ...........................................................Thomas W. Clarkson<br />
1994 .......................................................................... Bruce Ames<br />
1995 ..................................................................... Emil A. Pfitzer<br />
1996 ........................................................................John F. Rosen<br />
1997 .......................................................................... (No Award)<br />
1998 ......................................................... Helmut Alfred Greim<br />
1999 .......................................................................... (No Award)<br />
2000 .....................Carole A. Kimmel and Janardan K. Reddy<br />
2001 ................................................................Samuel M. Cohen<br />
2002 ............................................................Dennis Paustenbach<br />
2003 ............................................................ Michael L. Dourson<br />
2004 ............................................................ Melvin E. Andersen<br />
2005 ........................................................................Rory Conolly<br />
AstraZeneca SOT/IUTOX Fellowship<br />
The AstraZeneca company sponsors a travel fellowship award<br />
annually through SOT and IUTOX. Awards will be available to<br />
senior scientists from a country where toxicology is underrepresented<br />
to assist with travel to attend the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong><br />
Annual Meeting.<br />
................................................................ Ping-kun Zhou (China)<br />
2003 .......................................................Jian-Hui Liang (China)<br />
........................................................Marjan G. Vracko (Slovenia)<br />
.................................................................... Eman A. Seif (Egypt)<br />
2004 ............................................ Cristina Bolaton (Phillipines)<br />
......................................................................... P.K. Gupta (India)<br />
.......................................... Salmaan Inayat-Hussain (Malaysia)<br />
..................................................................Xianping Ying (China)<br />
AstraZeneca Traveling<br />
Lectureship Awards<br />
The AstraZeneca Traveling Lectureship Awards are presented<br />
through the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> to recognize excellence in<br />
research and service in toxicology. AstraZeneca, Ltd., provides<br />
one or two awards annually to promote greater collaboration<br />
between European and North American toxicologists and to<br />
enable North American toxicologists to undertake a three-four<br />
week lecture tour <strong>of</strong> Europe. The awards are intended to familiarize<br />
recipients with research and regulatory issues in Europe<br />
as well as bring a North American perspective to these issues.<br />
Candidates for these awards should be established, mid-career<br />
North American scientists who are members <strong>of</strong> the <strong>Society</strong> and<br />
who demonstrate the ability to develop collaborative relationships<br />
with European colleagues. The awards are given each year<br />
in the amount <strong>of</strong> $6,000 each.<br />
Award Recipients<br />
1990 ............................. Robert I. Krieger, Joseph R. Landolph<br />
1991 ...........................................................................Sam Kacew<br />
1992 ........................................Charles V. Smith, Jerold A. Last<br />
1993 ........... Terrence James Monks, Harihara H. Mehendale<br />
1995 ............................. David L. Eaton, Hanspeter R. Witschi<br />
1996 .............................Rick G. Schnellmann, James P. Kehrer<br />
1997 .....................................Lucio G. Costa, Durisala Desaiah<br />
1998 .......................................Syed F. Ali, Curtis J. Omiecinski<br />
1999 ......................................................................... Alvaro Pugo<br />
2000 ............................................ Kenneth Ramos, Garold Yost<br />
2001 ...........................................Ronald Hines, Richard Seegal<br />
2003 ............................................................William D. Atchison<br />
2004 ........................................................ Charlene A. McQueen<br />
2005 ...................................................................... Kevin Cr<strong>of</strong>ton<br />
Award Recipients<br />
2002 ................................... Christophor Dishovsky (Bulgaria)<br />
............................................................ Zoltan Gregus (Hungary)<br />
............................................ Maritza Rojas Martini (Venezuela)<br />
..................................................... Choon-Nam Ong (Singapore)<br />
..................................................................W. Wasowicz (Poland)<br />
256<br />
SOT's 44 th Annual Meeting
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
Board <strong>of</strong> Publications Award<br />
The Board <strong>of</strong> Publications Award for the Best Paper in Toxicological<br />
Sciences is presented to the author(s) <strong>of</strong> the best paper published<br />
in this <strong>of</strong>ficial SOT publication during a 12-month period, terminating<br />
with the June issue <strong>of</strong> the calendar year preceding the<br />
Annual Meeting at which the award is presented. The author(s)<br />
need not be a member <strong>of</strong> the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>. Submissions<br />
should include a one-page summary <strong>of</strong> the paper’s contribution<br />
to the science <strong>of</strong> toxicology and a copy <strong>of</strong> the article for which<br />
the nomination is being made. Any member <strong>of</strong> the <strong>Society</strong> may<br />
submit one title for consideration. In addition, the titles <strong>of</strong> no<br />
more than six papers to be considered are submitted by the editor<br />
<strong>of</strong> Toxicological Sciences. All papers submitted will be evaluated<br />
by the Board <strong>of</strong> Publications. This award consists <strong>of</strong> a plaque and<br />
a cash stipend. (This award was formerly known as the Frank R.<br />
Blood Award.)<br />
Best Paper in Fundamental and Applied<br />
<strong>Toxicology</strong> and Toxicological Sciences<br />
Award Recipients<br />
1995 ......................J. L. Larson, D. C. Wolf, B. E. Butterworth<br />
1995 ........M. I. Luster, C. Portier, D. G. Pait, G. J. Rosenthal,<br />
................................D. R. Germolec, E. Corsini, B. L. Blaylock,<br />
............................ P. Pollock, Y. Kouchi, W. Craig, K. L. White,<br />
................................................... A. E. Munson, C. E. Comment<br />
1996 ....................... B. C. Allen, R. J. Kavlock, C. A. Kimmel,<br />
............................................................................. E. M. Faustman<br />
1997 ................F. L. Fort, H. Ando, T. Suzuki, M. Yamamoto,<br />
........................................... T. Hamashima, S. Sato, T. Kitazaki,<br />
.......................................................M. C. Matony, G. D. Hodgen<br />
1998 .............. D. D. Parrish, M. J. Schlosser, J. C. Kapeghian,<br />
................................................................................... V. M. Traina<br />
1999 .................. C. A. Franklin, M. J. Inskip, C. L. Baccanale,<br />
.............................. C. M. Edwards, W. I. Manton, E. Edwards,<br />
.............................................................................. E. J. O’Flaherty<br />
2000 .......................H.A Boulares, C. Giardina, C.L. Navarro,<br />
....................................................... E.A. Khairallah, S.D. Cohen<br />
2001 .................. Jinqiang Chen, Yunbo Li, Jackie A. Lavigne,<br />
............................................. Michael A. Trush, James D. Yager<br />
2002 ........................ M.J. Bajt, J.A. Lawson, S.L. Vonderfecht,<br />
................................................................. J.S. Gujral, H. Jaeschke<br />
2003 .............S. Haddad, M. Beliveau, R. Tardif, K. Krishnan<br />
2004 ..................................Urmila Kodavanti, Carolyn Moyer,<br />
.................Allen Ledbetter, Mette Schlasweiler, Daniel Costa,<br />
.................... Russ Hauser, David Christiani, Abraham Nyska<br />
2005 ....................................Nicole V. Soucy, Michael A. Ihnat,<br />
...................................Chandrashekhar D. Kamat, Linda Hess,<br />
......................................................... Mark J. Post, Linda R. Klei,<br />
.................................................Callie Clark, Aaron Barchowsky<br />
up-to-date information at www.toxicology.org 257<br />
Best Paper in <strong>Toxicology</strong> and Applied<br />
Pharmacology<br />
Award Recipients<br />
1995 .........................M. F. Denny, M. F. Ware, W. D. Atchison<br />
1996 ........... T. A. Slotkin, C. Lau, E. C. McCook, S. E. Lappi,<br />
..................................................................................... F. J. Seidler<br />
1997 ..............P. R. S. Kodavanti, T. R. Ward, J. D. McKinney,<br />
............................................................ C. L. Waller, H. A. Tilson<br />
1998 ......................J. S. Landin, S. D. Cohen, E. A. Khairallah<br />
1999 .............................. S. K. Ramaiah, M G. Soni, T. J. Bucci,<br />
........................................................................ H. M. Mehendale,<br />
1999 ................. C. L. Zuch, D. J. O’Mara, D. A. Cory-Slechta<br />
2000 .......................... J.E. Staples, N.C. Fiore, D.E. Frazier, Jr.,<br />
................................................ T.A. Gasiewicz, A.E. Silverstone<br />
2001 ................................. Barbara J. Mounho, Brian D. Thrall<br />
2002 ................................. G.S. Ratra, S.G. Kamita, J.E. Casida<br />
2003 ............................ J. Doorn, M. Schall, D. Gage, T. Talley,<br />
.......................................................C. Thompson, R. Richardson<br />
Award Recipients (Frank R. Blood Award)<br />
1974 ............................................................................Yves Alarie<br />
1975 ......Donald J. Ecobichon, G. J. Johnstone, O. Hutzinger<br />
1976 ................................................................Richard D. Brown<br />
1977 ............ J. Dedinas, George D. DiVincenzo, C. J. Kaplan<br />
1978 ..........Perry J. Gehring, E. O. Madrid, G. R. McGowan,<br />
....................................................................... Philip G. Watanabe<br />
1979 ...... R. Fradkin, E. J. Ritter, W. J. Scott, James G. Wilson<br />
1980 ............... Jerold A. Last, Peter F. Moore, Otto G. Raabe,<br />
..................................................................... Brian K. Tarkington<br />
1981 .................................................Yves Alarie, Martin Brady,<br />
......................................................Christine Dixon, Meryl Karol<br />
1982 .........................Melvin E. Andersen, Michael L. Gargas,<br />
....................................Lawrence J. Jenkins, Jr., Robert A. Jones<br />
1983 .....................................................................Henry D. Heck<br />
1984 ................Erik Dybing, Sidney Nelson, Erik Soderlund,<br />
..........................................................................Christer Von Bahr<br />
1985 ........ Nobumasa Imura, Masae Inokawa, Kyoko Miura<br />
1986 .............Calvin C. Wilhite, M. I. Dawson, K. J. Williams<br />
1987 ..................... John Kao, Frances K. Patterson, Jerry Hall<br />
1988 ................Debra L. Laskin, Sungchul Ji, Anne M. Pilaro<br />
1989 ........................................... R. G. Cuddihy, W. C. Griffith,<br />
.................................... Rogene F. Henderson, Joe L. Mauderly,<br />
............... Roger O. McClellan, M. D. Snipes, Ronald K. Wolff<br />
1990 ........................William P. Beierschmitt, Joseph T. Brady,<br />
..........................................John B. Bartolone, D. Stuart Wyand,<br />
...................................Edward A. Khairallah, Steven D. Cohen<br />
1991 ...............................Jay Babcock Silkworth, Daryl Cutler,<br />
............... LuAnn Antrim, Don Houston, Casimir Tumasonis,<br />
..................................................................Laurence S. Kaminsky<br />
1992 .........Donald A. Fox, Steve D. Rubinstein, Pauline Hsu<br />
1993 ........ Thomas Mably, Robert W. Moore, Robert W. Goy,<br />
.......................................................................Richard E. Peterson<br />
1994 ............................Susan J. Borgh<strong>of</strong>f, William H. Lagarde<br />
REFERENCE
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
REFERENCE<br />
Colgate-Palmolive Post-Doctoral<br />
Fellowship Award in In Vitro <strong>Toxicology</strong><br />
The Colgate-Palmolive Company sponsors the Colgate-Palmolive<br />
Post-Doctoral Fellowship Award in In Vitro <strong>Toxicology</strong> through<br />
the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> to advance the development <strong>of</strong> alternatives<br />
to animal testing in toxicological research. The award is<br />
given in alternate years and includes stipend and research-related<br />
costs (up to $33,500) for one year. The award may be extended for<br />
an additional year upon agreement between Colgate-Palmolive<br />
and the post-doctoral fellow. Post-doctoral trainees in their first<br />
year <strong>of</strong> study beyond the Ph.D., M.D. or D.V.M. degree who are<br />
employed by academic institutions, federal/national laboratories<br />
or research institutes worldwide may apply. The Education<br />
Committee reviews applications, which are due in even calendar<br />
years, and the fellowship is awarded for the following year. The<br />
next application deadline: October 9, 2005.<br />
Award Recipients<br />
1988 ........................................................................Ernest Bloom<br />
1989 ..............................................................................Gin Hsieh<br />
1990 ............................................................Dennis E. Chapman<br />
1991 ..........................................................................Anne Walsh<br />
1992 .............................................................................. Qin Chen<br />
1993 ........................................................................Erika Cretton<br />
1994 ....................................................................... William Chan<br />
1995 ................................................................Bob Van de Water<br />
1997 ......................................................................... Alan Parrish<br />
1999 ....................................................................Russell Thomas<br />
2001 .....................................Kevin Kerzee, Christopher Reilly<br />
2002 ........................................................................Kevin Kerzee<br />
2003 ................................................................... Kimberly Miller<br />
2004 ................................................................... Kimberly Miller<br />
Colgate-Palmolive/SOT Awards for<br />
Student Research Training in Alternative<br />
Methods<br />
The purpose <strong>of</strong> the Colgate-Palmolive/SOT Awards for Student<br />
Research Training in Alternative Methods is to enhance student<br />
research training using in vitro methods or alternative techniques<br />
to reduce, replace or refine use <strong>of</strong> animals in toxicological research.<br />
The Education Committee will present the awards to graduate<br />
students or to institutions that provide research internships. Up<br />
to six awards, at $2,500 each, are available. Applications received<br />
after October 9 will be accepted until all funds are committed.<br />
Graduate Students: The award will help to defray expenses for<br />
graduate students in toxicology to visit an <strong>of</strong>f-site laboratory<br />
for the purpose <strong>of</strong> gaining knowledge about and developing in<br />
vitro or alternative toxicology techniques that will support the<br />
student’s dissertation research. The overall goal <strong>of</strong> this program is<br />
to support the replacement, reduction or refinement <strong>of</strong> currently<br />
used animal models in toxicology research and testing.<br />
Institutions: Awards will also be made to institutions that<br />
propose a 10-week research experience for students (at any<br />
level) involving in vitro toxicology or alternative methods to<br />
reduce, replace, or refine, the use <strong>of</strong> animals in toxicology<br />
research.<br />
Award Recipients<br />
2000 ...........................................................................Jason Gross<br />
2001 ...........................................Jason Biggs, Victoria Richards<br />
2002 ...... Kartik Shankar, Chad M. Vezina, Ryan L. Williams<br />
2003 ...........Sachin Devi, Midhun Korrapati, Pallavi Limaye<br />
2004 ..............................Jaya Chilakapati, Ankur Dnyanmote,<br />
...........................................................................Johnathan Maher<br />
258<br />
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
Colgate-Palmolive Traveling Lectureship<br />
in Alternative Methods in <strong>Toxicology</strong><br />
Award<br />
The Colgate-Palmolive Company sponsors the Colgate-Palmolive<br />
Traveling Lectureship in Alternative Methods in <strong>Toxicology</strong><br />
Award annually through the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>. This award<br />
covers expenses for an individual scholar to visit institution(s)<br />
for the dissemination <strong>of</strong> knowledge and for stimulating research<br />
that takes advantage <strong>of</strong> modern in vitro toxicology approaches.<br />
The overall goal <strong>of</strong> this program is to make scientists aware <strong>of</strong><br />
the benefits <strong>of</strong> modern in vitro toxicology approaches and to<br />
stimulate research for the replacement, reduction or refinement <strong>of</strong><br />
currently used animal models. The scholar may be asked to make<br />
a special presentation at the SOT Annual Meeting.<br />
Lecturing scholars should be established, mid-career through<br />
late-career scientists who are members <strong>of</strong> SOT and who are<br />
developing collaborative relationships with scientists at other<br />
institutions.<br />
Requests for funds can be made by the individual scholar or<br />
by organizations such as universities, colleges, SOT Specialty<br />
Sections and SOT Regional Chapters, and other toxicology organizations<br />
that are interested in inviting the scholar. Up to $15,000<br />
is available. The Awards Committee reviews the applications,<br />
which must be accompanied by a statement <strong>of</strong> the applicant’s<br />
experience, a brief overview <strong>of</strong> the techniques to be discussed in<br />
the lecture, and a letter from the hosting institution(s) indicating<br />
their interest in serving as host and the potential benefits to the<br />
institution.<br />
Award Recipients<br />
1996 .......................University <strong>of</strong> Mississippi Medical Center<br />
Visiting Pr<strong>of</strong>essor: .................................................Tetsuo Satoh<br />
1996 ........................................ University <strong>of</strong> Illinois at Urbana<br />
Visiting Pr<strong>of</strong>essor: ...................................................Julio Davila<br />
1996 ..............................................Mississippi State University<br />
Visiting Pr<strong>of</strong>essor: ...................................... Michael Holsapple<br />
1996 .............................................Washington State University<br />
Visiting Pr<strong>of</strong>essor: ...............................................Daniel Acosta<br />
1997 ........................... Indiana University School <strong>of</strong> Medicine<br />
Visiting Pr<strong>of</strong>essor: ............................................ A. Jay Gandolfi<br />
1997 .................University <strong>of</strong> Arizona Health Science Center<br />
Visiting Pr<strong>of</strong>essor: ..........................................Kevin E. Driscoll<br />
1997 .......University <strong>of</strong> New Mexico Health Sciences Center<br />
Visiting Pr<strong>of</strong>essor: ...................................................Sam Kacew<br />
1997 ...........................................................University <strong>of</strong> Illinois<br />
Visiting Pr<strong>of</strong>essor: ..........................................Michael Denison<br />
1998 ..................................................University <strong>of</strong> Washington<br />
Visiting Pr<strong>of</strong>essor: ................................................Bruce Fowler<br />
1998 ................................................San Diego State University<br />
Visiting Pr<strong>of</strong>essor: ............................... Leigh Ann Burns Naas<br />
1999 ................................................San Diego State University<br />
Visiting Pr<strong>of</strong>essor: ..............................................Robert Chapin<br />
2000 .................................Yale University, School <strong>of</strong> Medicine<br />
Visiting Pr<strong>of</strong>essor: ........................................... Narendre Singh<br />
2001 ...........................................Medical College <strong>of</strong> Wisconsin<br />
Visiting Pr<strong>of</strong>essor: ...................................................Garold Yost<br />
2003 .............................................Washington State University<br />
Visiting Pr<strong>of</strong>essor: ............................................. Marc W. Fariss<br />
2004 ........................................................ Snorri S. Thorgeirsson<br />
Institution to be Visited: ....................................... University <strong>of</strong><br />
.....................................................................Louisiana at Monroe<br />
Contributions to Public Awareness<br />
<strong>of</strong> the Importance <strong>of</strong> Animals in<br />
<strong>Toxicology</strong> Research Award<br />
The Contributions to Public Awareness <strong>of</strong> the Importance <strong>of</strong><br />
Animals in <strong>Toxicology</strong> Research Award is presented annually to<br />
an individual (or organization) in recognition <strong>of</strong> the contributions<br />
made to the public understanding <strong>of</strong> the role and importance <strong>of</strong><br />
experimental animals in toxicological science. This award may<br />
be for either a single seminal piece <strong>of</strong> work or a longer-term<br />
contribution to public understanding <strong>of</strong> the necessity <strong>of</strong> the use <strong>of</strong><br />
animals in toxicological research both to ensure and enhance the<br />
quality <strong>of</strong> human and animal health and the environment. The<br />
award consists <strong>of</strong> a plaque and a cash stipend.<br />
Award Recipients<br />
2000 ..................................................... Allegheny-Erie Chapter<br />
2001 ..................Massachusetts <strong>Society</strong> for Medical Research<br />
2002 ...............................................................George Nethercutt<br />
2003 .............................................................. Michael Derelanko<br />
2004 .........................................North Carolina Association for<br />
..................................................Biomedical Research (NCABR),<br />
....................................Americans for Medical Progress (AMP)<br />
2005 ........................................Orrin G. Hatch, Foundation for<br />
.....................................................................Biomedical Research<br />
REFERENCE<br />
up-to-date information at www.toxicology.org 259
44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
REFERENCE<br />
Distinguished Lifetime <strong>Toxicology</strong><br />
Scholar Award<br />
The Distinguished <strong>Toxicology</strong> Scholar Award is presented to a<br />
member <strong>of</strong> SOT who has made substantial and seminal scientific<br />
contributions to the discipline <strong>of</strong> toxicology. The prime consideration<br />
for this award is scientific accomplishments and not<br />
necessarily service to the <strong>Society</strong>. This award consists <strong>of</strong> a plaque<br />
and a cash stipend. (This award was formerly known as the<br />
Scientific Achievement Award.)<br />
Award Recipients (Scientific Achievement<br />
Award)<br />
2001 ....................................................................James E. Troska<br />
Award Recipients<br />
2003 ......................................................................Henry C. Pitot<br />
2004 .................................................................Gerald N. Wogan<br />
2005 .......................................................................Daniel Nebert<br />
Education Award<br />
The Education Award is presented to an individual who is<br />
distinguished by the teaching and training <strong>of</strong> toxicologists and<br />
who has made significant contributions to education in the<br />
broad field <strong>of</strong> toxicology. This award consists <strong>of</strong> a plaque and a<br />
cash stipend.<br />
Award Recipients<br />
1975 .................................................................Harold C. Hodge<br />
1976 ......................................................................Ted A. Loomis<br />
1977 ..................................................................Robert B. Forney<br />
1979 ............................................................ Sheldon D. Murphy<br />
1980 ............................................................. Herbert H. Cornish<br />
1981 ...............................................................Frederick Sperling<br />
1982 .............................................................. Lloyd W. Hazleton<br />
1983 .....................................................................Julius M. Coon<br />
1984 ........................................Frank Guthrie, Ernest Hodgson<br />
1985 ................................................................... William B. Buck<br />
1986 ..................................................................Robert I. Krieger<br />
1987 ..................................................................... Gabriel L. Plaa<br />
1988 .......................................................................... John Autian<br />
1989 ........................................................................ Tom S. Miya<br />
1990 ...................................................................Charles H. Hine<br />
1991 .......................................................... Hanspeter R. Witschi<br />
1992 ..................................................................... Dean E. Carter<br />
1993 ...............................................................Curtis D. Klaassen<br />
1994 ..................................................................... Robert A. Neal<br />
1995 ................................................................... William Carlton<br />
1996 ...................................................................... Robert Snyder<br />
1997 ................................................................Albert E. Munson<br />
1998 ............................................................... David J. Holbrook<br />
1999 ....................................................................... Jules Brodeur<br />
2000 ........................................................................Gary Carlson<br />
2001 ...........................................................Harihara Mehendale<br />
2002 ................................................................ Joseph Borzelleca<br />
2003 ........................................................... Frederick W. Oehme<br />
2004 .................................................................... A. Jay Gandolfi<br />
2005 ....................................................................... Nobuyuki Ito<br />
Enhancement <strong>of</strong> Animal Welfare<br />
Award<br />
The Enhancement <strong>of</strong> Animal Welfare Award is presented annually<br />
to a member <strong>of</strong> the <strong>Society</strong> in recognition <strong>of</strong> the contribution<br />
made to the advancement <strong>of</strong> toxicological science through the<br />
development and application <strong>of</strong> methods that replace, refine, or<br />
reduce the need for experimental animals. This award recognizes<br />
outstanding/significant contributions made by members <strong>of</strong> the<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> to the scientifically sound and responsible<br />
use <strong>of</strong> animals in research. The achievement recognized may be<br />
either a seminal piece <strong>of</strong> work or a long-term contribution to<br />
toxicological science and animal welfare. The award consists <strong>of</strong> a<br />
plaque and a cash stipend.<br />
Award Recipients<br />
2000 ............................................................................Yves Alarie<br />
2001 ..................................................................... Alan Goldberg<br />
2002 ......................................................................Gary Williams<br />
2003 ....................................... G. Frank Gerberick, Ian Kimber<br />
2005 .......................................................................Daniel Acosta<br />
Graduate Student Fellowship Awards<br />
The Graduate Student Fellowship Awards are provided by<br />
generous sponsors and are open to student members <strong>of</strong> the SOT<br />
engaged in full-time graduate study towards a Ph.D. degree<br />
in toxicology. The major pr<strong>of</strong>essor must be a SOT member.<br />
The Education Committee’s evaluation is based primarily on<br />
originality <strong>of</strong> the dissertation research, research productivity,<br />
relevance to toxicology, scholastic achievement, and letters <strong>of</strong><br />
recommendation. Finalists are interviewed at the Annual Meeting<br />
and receive travel support.<br />
Novartis Corporation Graduate<br />
Fellowship<br />
Award Recipients<br />
1989 .........................................................Timothy Zacharewski<br />
1990 .................................................... Mary Suzanne Stefaniak<br />
1991 ...................................................................... Donald Bjerke<br />
1992 ..................................................... Lhanoo Gunawardhana<br />
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1993 ...................................................... Christopher Martenson<br />
1994 .........................................................................Nyla Harper<br />
1995 ...............................................................Heather E. Kleiner<br />
1996 ....................................................................Russell Thomas<br />
1997 .............................................................Melva Rios-Blancos<br />
1998 ........................................................................ Kent Carlson<br />
1999 .....................................................................Mark Hickman<br />
2000 ....................................................................... Jeffrey Moran<br />
2001 ....................................................................... Vishal Vaidya<br />
2002 .....................................................................Kartik Shankar<br />
2003 .......................................................................... Sachin Devi<br />
2004 ..................................................................James Luyendyk<br />
(Recipients <strong>of</strong> Graduate Fellowship Awards no longer <strong>of</strong>fered may be found<br />
on the SOT Web site at www. toxicology.org.)<br />
Graduate Student Travel Awards<br />
Graduate Student Travel Awards defray expenses for students<br />
presenting platform talks or posters at the SOT Annual Meeting.<br />
To be eligible, the student must be a SOT member (or have<br />
submitted a membership application) who has not previously<br />
received a graduate student travel award. Each institution may<br />
rank and submit applications from up to three students.<br />
Honorary Membership<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> recognizes non-members who embody<br />
outstanding and sustained achievements in the field <strong>of</strong> toxicology<br />
with the Honorary Member Award. Candidates are nominated<br />
by two voting or associate members <strong>of</strong> the <strong>Society</strong>. Seconding<br />
letters and information regarding career achievements in toxicology<br />
should accompany the nomination. A two-thirds vote <strong>of</strong><br />
Council determines recipients, with not more than two Honorary<br />
Members elected during any one term <strong>of</strong> Council. Nominations<br />
should be sent to SOT Headquarters.<br />
Inductees<br />
1997 ......................................................................John E. Casida<br />
1997 ................................................................Roger W. Russell*<br />
1998 ...............................................................................Jud Coon<br />
1998 .....................................................................Michel Mercier<br />
1999 ......................................................... William O. Robertson<br />
1999 ................................................................Takashi Sugimura<br />
2000 .................................................................... Findlay Russell<br />
2001 ............................................................ Herbert Needleman<br />
Merit Award<br />
The Merit Award is presented to a member <strong>of</strong> the <strong>Society</strong> <strong>of</strong><br />
<strong>Toxicology</strong> in recognition <strong>of</strong> a distinguished career in toxicology.<br />
This award consists <strong>of</strong> a plaque and a cash stipend.<br />
Award Recipients<br />
1966 ..............................................................Henry F. Smyth, Jr.<br />
1967 ................................................................Arnold J. Lehman<br />
1968 .......................................................................R. T. Williams<br />
1969 .................................................................Harold C. Hodge<br />
1970 ..........................................................................Don D. Irish<br />
1971 .............................................................. Kenneth P. DuBois<br />
1972 ...............................................................O. Garth Fitzhugh<br />
1973 ........................................................... Herbert E. Stokinger<br />
1974 ........................................................William B. Deichmann<br />
1975 ............................................................ Frederick Coulston*<br />
1976 .................................................................. Verald K. Rowe*<br />
1977 .....................................................................Harry W. Hays<br />
1978 .....................................................................Julius M. Coon<br />
1979 ..................................................................David W. Fassett<br />
1980 ................................................................... Bernard L. Oser<br />
1981 .............................................................John H. Weisburger<br />
1982 ....................................................................Harold M. Peck<br />
1983 ................................................................. Perry J. Gehring*<br />
1984 ......................................................................... Tom S. Miya<br />
1985 ....................................................................... Carrol S. Weil<br />
1986 ......................................................................Ted A. Loomis<br />
1987 .......................................................................Bo Holmstedt<br />
1988 ................................................................Seymour L. Friess<br />
1989 .........................................................Wayland J. Hayes, Jr.*<br />
1990 ............................................................ Sheldon D. Murphy<br />
1991 ............................................................... Toshio Narahashi<br />
1992 ..........................................................W. Norman Aldridge<br />
1993 ............................................................................ John Doull<br />
1994 ...................................................................Ernest Hodgson<br />
1995 .....................................................................Robert A. Scala<br />
1996 ..................................................................... Gabriel L. Plaa<br />
1997 ...................................................................Mary O. Amdur<br />
1998 ................................................................... John A. Thomas<br />
1999 ................................................................ Thomas Clarkson<br />
2000 ................................................................... Philippe Shubik<br />
2001 ........................................................................ Donald Reed<br />
2002 ................................................................. Bernard Schwetz<br />
2003 ........................................................................ M.W. Anders<br />
2004 ........................................................................Robert Goyer<br />
1962 .........................................................Eugene M.K. Geiling*<br />
1962 ...........................................................W. F. Von Oettingen*<br />
1962 ..............................................................Torald H. Sollman*<br />
1963 .................................................................. Ethel Browning*<br />
1966 ...........................................................R. Tecwyn Williams*<br />
1976 ................................................................... Norton Nelson*<br />
1982 ......................................................... George H. Hitchings*<br />
1986 .............................................................. Bernard B. Brodie*<br />
1986 ................................................................. Herbert Remmer<br />
1991 ......................................................Hyman J. Zimmerman*<br />
1994 .......................................................... Ronald W. Estabrook<br />
1994 ...............................................................Wendell W. Weber<br />
1995 ...............................................................Gertrude B. Elion*<br />
1995 ..................................................................Charles S. Lieber<br />
1996 ..................................................................Sten G. Orrenius<br />
1996 ........................................................................Dennis Parke<br />
2005 ..................................................................Roger McClellan<br />
up-to-date information at www.toxicology.org 261<br />
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44 th Annual Meeting<br />
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<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> Awards (Continued)<br />
REFERENCE<br />
Minority Undergraduate Student<br />
and Advisor Awards<br />
The Minority Undergraduate Student and Advisor Awards<br />
provide support for awardees to participate in the Undergraduate<br />
Education <strong>Program</strong> at the SOT Annual Meeting. This program<br />
is an introduction to the discipline <strong>of</strong> toxicology for undergraduate<br />
science majors and includes an orientation, a special<br />
poster session with scientists, and activities with a SOT mentor.<br />
The travel awards are for those from races and ethnic groups<br />
under-represented in the sciences (African American, American<br />
Indian or Hispanic American) and for their advisors. Advisors are<br />
eligible regardless <strong>of</strong> racial or ethnic background. Meeting registration<br />
and support for travel, lodging, and meals are provided<br />
for students and advisors who are not local to the meeting site.<br />
Students and advisors from local institutions receive meeting<br />
and program registration and meals. In the past, the program<br />
has been supported in part by NIH-MARC, Pfizer, and Johnson<br />
& Johnson.<br />
Regional Chapter Awards<br />
Most SOT Regional Chapters provide awards to recognize<br />
outstanding students or scientists. Application requirements<br />
and deadlines vary. Visit the Regional Chapter or Awards and<br />
Fellowship sections on the SOT Web site for full details.<br />
<strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>/American<br />
Chemistry Council Early Career Award<br />
The American Chemistry Council <strong>of</strong>fers an Early Career Award<br />
through the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>. The award is up to $100,000<br />
and is designed to encourage persons beginning their pr<strong>of</strong>essional<br />
careers to conduct research that will improve the scientific<br />
basis for risk assessment and decision making with respect to a<br />
particular specialty area <strong>of</strong> potential toxicity <strong>of</strong> chemicals. Awards<br />
have been <strong>of</strong>fered in Inhalation and Neurotoxicology. Full details<br />
are available on the SOT Web site.<br />
Public Communications Award<br />
The Public Communications Award is presented by the <strong>Society</strong><br />
<strong>of</strong> <strong>Toxicology</strong> to recognize an individual who has made a major<br />
contribution to broadening the awareness <strong>of</strong> the general public<br />
on toxicological issues through any aspect <strong>of</strong> public communications.<br />
The award should reflect accomplishments made over<br />
a significant period <strong>of</strong> time. Examples <strong>of</strong> qualifying media in<br />
which the nominated communication may appear are: books,<br />
brochures, continuing education courses, data bases, extension<br />
bulletins, magazines, newspapers (local or national), public<br />
presentations, public forums, radio and television scripts, and<br />
workshops. The award consists <strong>of</strong> a plaque and a cash stipend.<br />
Awards Recipients<br />
1994 ..............................................................Michael A. Kamrin<br />
1995 ..................................................................... Philip Abelson<br />
1996 .....................................................................Bruce N. Ames<br />
1997 .....................................................................Audrey Gotsch<br />
1999 .................................................................... Ann de Peyster<br />
2001 ................................................................... Anna Shvedova<br />
2002 ...........................................................................Sam Kacew<br />
2003 ........................................................ Charlene A. McQueen<br />
2004 .................................................................... Kenneth Olden<br />
2005 ..................................................................... Robert Kreiger<br />
Award Recipients<br />
2002 ................................ Ronald Tjalkens (Neurotoxicololgy)<br />
2003 ...................................................Ilona Jaspers (Inhalation)<br />
2004 .................................Nikolay Filipov (Neurotoxicololgy)<br />
Specialty Section Student Awards<br />
Most SOT Specialty Sections provide awards to recognize<br />
outstanding student presentations at the SOT Annual Meeting.<br />
Application requirements and deadlines vary. For more<br />
details refer to the Award descriptions on the SOT Web site at<br />
www.toxicology.org, under Specialty Sections or the Awards and<br />
Fellowships sections<br />
262<br />
SOT's 44 th Annual Meeting
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<strong>Toxicology</strong> Specialists<br />
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REFERENCE<br />
The <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong> has established a <strong>Toxicology</strong> Specialists <strong>Program</strong> to assist journalists and members <strong>of</strong> the public in identifying<br />
or locating expert toxicologists who can provide factual information on issues <strong>of</strong> public concern. The <strong>Toxicology</strong> Specialists<br />
provide information based on their own credentials and do not represent the views <strong>of</strong> the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>. Nominations are<br />
accepted throughout the year. Applications may be found on the SOT Web site (www.toxicology.org). For further information, please<br />
contact SOT Headquarters at (703) 438-3115, or e-mail sothq@toxicology.org.<br />
Specialties:<br />
Carcinogenesis<br />
Jane A. S. Allen<br />
James Bond<br />
Richard Bull<br />
Yvonne Dragan<br />
David L Eaton<br />
James E. Klaunig<br />
Michael McClain<br />
Charlene A. McQueen<br />
Henry Pitot<br />
James Popp<br />
Robert Rubin<br />
Jacqueline H. Smith<br />
Cheryl Lyn Walker<br />
Comparative and<br />
Veterinary<br />
Roger McClellan<br />
Epidemiology<br />
Ellen Silbergeld<br />
General <strong>Toxicology</strong><br />
Jane A. S. Allen<br />
Linda Birnbaum<br />
Yvonne Dragan<br />
David L. Eaton<br />
Sidney Green<br />
James E. Klaunig<br />
Robert Krieger<br />
Michael McClain<br />
Kendall B. Wallace<br />
Genetic <strong>Toxicology</strong><br />
Jane A. S. Allen<br />
Sidney Green<br />
James E. Klaunig<br />
Charlene A. McQueen<br />
(environmental)<br />
Cheryl Lyn Walker<br />
Immunotoxicology<br />
Scott Burchiel<br />
Jack Dean<br />
Jay Gandolfi (hypersensitivity)<br />
Norbert Kaminski<br />
Nancy Kerkvliet<br />
Kathleen Rodgers<br />
Mary Jane Selgrade<br />
In Vitro<br />
Daniel Acosta, Jr.<br />
Yvonne Dragan<br />
Elaine M. Faustman<br />
Jay Gandolfi<br />
Kenneth S. Ramos<br />
Rick Schnellmann<br />
Jacqueline H. Smith<br />
Inhalation/Pulmonary<br />
Barbara Beck<br />
James Bond<br />
Gary Boorman (pulmonary<br />
pathology)<br />
Robert Drew<br />
Roger McClellan<br />
John Morris<br />
Robert Phalen<br />
Gary Yost<br />
Kidney Toxicity<br />
William Berndt<br />
Steven D. Cohen<br />
Mary Davis<br />
Ernest Foulkes<br />
Jay Gandolfi<br />
Robin Goldstein<br />
Lois D. Lehman-McKeeman<br />
Rick Schnellmann<br />
Liver Toxicity<br />
Steven D. Cohen<br />
George B. Corcoran<br />
Mary Davis<br />
Yvonne Dragan<br />
Jay Gandolfi<br />
Robin Goldstein<br />
James E. Klaunig<br />
Jose E. Manautou<br />
Hari Mehendale<br />
James Popp<br />
Mechanisms<br />
Daniel Acosta, Jr.<br />
Jane A. S. Allen<br />
William Berndt<br />
Linda Birnbaum<br />
Gary P. Carlson<br />
George B. Corcoran<br />
Ann de Peyster<br />
Yvonne Dragan<br />
Elaine M. Faustman<br />
Jay Gandolfi<br />
James E. Klaunig<br />
Lois D. Lehman-McKeeman<br />
Jose E. Manautou<br />
Hari Mehendale<br />
James Popp<br />
Kenneth S. Ramos<br />
Stephen Safe<br />
Rick Schnellmann<br />
Ellen Silbergeld<br />
Kendall B. Wallace<br />
Gary Yost<br />
Metabolism/<br />
Toxicokinetics<br />
Linda Birnbaum<br />
George B. Corcoran<br />
Lois D. Lehman-McKeeman<br />
Raymond Novak<br />
Molecular<br />
Elaine M. Faustman<br />
William Greenlee<br />
Norbert Kaminski<br />
Henry Pitot<br />
Kenneth S. Ramos<br />
Robert Rubin<br />
Raymond Novak (cell signaling,<br />
gene expression)<br />
Kendall B. Wallace<br />
Gary Yost<br />
Neurotoxicity<br />
Marion F. Ehrich<br />
Robert Krieger<br />
Joel Mattsson<br />
Ellen Silbergeld<br />
William Slikker<br />
Hugh Tilson<br />
Regulatory<br />
<strong>Toxicology</strong>/<br />
Regulatory Affairs/<br />
Safety Evaluation<br />
Daniel Acosta, Jr. (drugs/addictive<br />
agents)<br />
Jane A. S. Allen<br />
Gregory Allgood<br />
Richard Bull<br />
Jack Dean (drugs)<br />
Michael Dourson<br />
Robin Goldstein (drugs)<br />
Robert A. Kuna<br />
James Lamb (pesticides and<br />
industrial chemicals)<br />
Michael McClain (drugs)<br />
Kathleen Rodgers (drugs)<br />
Robert Rubin<br />
Reproductive/<br />
Developmental<br />
Robert Chapin<br />
George Daston<br />
Ann de Peyster<br />
Elaine M. Faustman<br />
Carole A. Kimmel<br />
James Lamb<br />
Hugh Tilson (developmental<br />
neurotoxicology)<br />
Risk Assessment<br />
Barbara Beck<br />
Michael Bolger<br />
James Bond<br />
Richard Bull<br />
John Christopher<br />
Rory Conolly<br />
Michael Dourson<br />
Elaine M. Faustman<br />
Jay I. Goodman<br />
Carole A. Kimmel<br />
Robert A. Kuna<br />
James Lamb<br />
Roger McClellan<br />
Robert Rubin<br />
Jacqueline H. Smith<br />
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<strong>Toxicology</strong> Specialists (Continued)<br />
ISSUES:<br />
Air Pollution<br />
James Bond<br />
Robert Drew (air quality standards)<br />
Roger McClellan (air quality<br />
standards-environmental and<br />
occupational)<br />
John Morris<br />
Robert Phalen<br />
Mary Jane Selgrade<br />
Animal Studies/<br />
Animals in Research<br />
Gary Boorman<br />
Stephen DiZio<br />
Robert Phalen<br />
Biotechnology/<br />
Biopharmaceutical<br />
<strong>Toxicology</strong><br />
Scott Burchiel<br />
Chemical-Chemical<br />
Interactions<br />
Steven D. Cohen<br />
Jay Gandolfi<br />
Chlorine-Based<br />
Compounds<br />
Richard Bull<br />
Rory Conolly<br />
Jay Gandolfi (also fluorine<br />
compounds)<br />
James E. Klaunig<br />
H. B. Matthews<br />
Hugh Tilson (PCBs)<br />
Dioxins/PCBs<br />
Linda Birnbaum<br />
Michael Bolger<br />
Rory Conolly<br />
David L. Eaton<br />
William Greenlee<br />
Norbert Kaminski<br />
Nancy Kerkvliet<br />
Kenneth S. Ramos<br />
Ellen Silbergeld<br />
Hugh Tilson<br />
Endocrine Disrupters<br />
Linda Birnbaum<br />
Michael Bolger<br />
James S. Bus<br />
Robert Chapin<br />
Rory Conolly<br />
Michael Gallo<br />
Nancy Kerkvliet<br />
James Lamb<br />
Cheryl Lyn Walker<br />
Food Additives/Food<br />
Safety/Food Toxins<br />
Gregory Allgood<br />
Michael Dourson<br />
David L. Eaton (especially<br />
aflatoxins)<br />
Robert A. Kuna<br />
Robert Rubin<br />
Free Radicals/<br />
Oxidative Stress/<br />
Antioxidants<br />
Gregory Allgood<br />
James Kehrer<br />
James E. Klaunig<br />
Kendall B. Wallace<br />
Industrial Chemical<br />
<strong>Toxicology</strong><br />
James S. Bus<br />
Robert A. Kuna<br />
Kendall B. Wallace<br />
Medical Devices<br />
Scott Burchiel<br />
Kathleen Rodgers<br />
Stephen Safe<br />
Metals<br />
Barbara Beck<br />
William Berndt<br />
Michael Bolger<br />
Ernest Foulkes<br />
Jay Gandolfi<br />
Hugh Tilson (lead, methyl mercury)<br />
Natural Toxins<br />
Michael Bolger<br />
Joel Mattsson<br />
Pesticides<br />
James S. Bus<br />
Marion F. Ehrich<br />
Robert Krieger<br />
James Lamb<br />
H. B. Matthews<br />
Kathleen Rodgers<br />
Stephen Safe<br />
Radiation<br />
Gary Boorman (EMF exposure)<br />
Mary Jane Selgrade<br />
Solvents<br />
Mary Davis<br />
Kendall B. Wallace<br />
up-to-date information at www.toxicology.org 265<br />
Validation <strong>of</strong><br />
Alternative Methods<br />
Sidney Green<br />
Water Pollution<br />
Richard Bull<br />
Regional<br />
Distribution:<br />
Central States<br />
William Berndt (NE)<br />
Kendall B. Wallace (MN)<br />
Gulf Coast (Texas)<br />
James Kehrer<br />
Kenneth S. Ramos<br />
Stephen Safe<br />
William Slikker<br />
Cheryl Lyn Walker<br />
Michigan<br />
James S. Bus<br />
George B. Corcoran<br />
Jay I. Goodman<br />
Norbert Kaminski<br />
Joel Mattsson<br />
Raymond Novak<br />
Mid-Atlantic<br />
Jack Dean (PA)<br />
Michael Gallo (NJ)<br />
Robin Goldstein (NJ)<br />
Robert A. Kuna (NJ)<br />
Michael McClain (NJ)<br />
James Popp (PA)<br />
Jacqueline H. Smith (NJ)<br />
Midwest<br />
James E. Klaunig (K)<br />
Henry Pitot (WI)<br />
Mountain West<br />
Scott Burchiel (NM)<br />
Jay Gandolfi (AZ)<br />
Roger McClellan (NM)<br />
Charlene A. McQueen (AZ)<br />
Gary Yost (UT)<br />
National Capital<br />
Michael Bolger (DC)<br />
Robert Drew (DC)<br />
Sidney Green (DC)<br />
Marion F. Ehrich<br />
Carole A. Kimmel (DC)<br />
James Lamb (VA)<br />
Robert Rubin (MD)<br />
Ellen Silbergeld (MD)<br />
North Carolina<br />
James A. S. Allen<br />
Linda Birnbaum<br />
James Bond<br />
Gary Boorman<br />
Rory Conolly<br />
William Greenlee<br />
H. B. Matthews<br />
Mary Jane Selgrade<br />
Hugh Tilson<br />
Northeast<br />
Barbara Beck (MA)<br />
Robert Chapin (CT)<br />
Steven D. Cohen (CT)<br />
Lois D. Lehman-McKeeman (NJ)<br />
Jose E. Manautou (CT)<br />
John Morris (CT)<br />
James A. Popp (CT)<br />
Northern California<br />
John Christopher<br />
Ann de Peyster<br />
Stephen DiZio<br />
Ohio Valley/<br />
Allegheny-Erie<br />
Daniel Acosta, Jr. (OH)<br />
Gregory Allgood (OH)<br />
George Daston (OH)<br />
Mary Davis (WV)<br />
Michael Dourson (OH)<br />
Ernest Foulkes (OH)<br />
Pacific Northwest<br />
Richard Bull (WA)<br />
David L. Eaton (WA)<br />
Elaine M. Faustman (WA)<br />
Nancy Kerkvliet (OR)<br />
South Central<br />
Yvonne Dragan (AR)<br />
Hari Mehendale (LA)<br />
Southeastern<br />
Rick Schnellmann (SC)<br />
Southern California<br />
Robert Krieger<br />
Robert Phalen<br />
Kathleen Rodgers<br />
REFERENCE
As an SOT Member you can . . .<br />
Stay connected at www.toxicology.org<br />
Access the members-only section <strong>of</strong> the SOT Web site.<br />
Keep informed <strong>of</strong> breaking news in toxicology,<br />
updated meeting and program information, and<br />
resources.<br />
Receive SOT Publications<br />
Members receive the electronic publications The<br />
Toxicologist on CD ROM, Communique, and Toxicological<br />
Sciences. Members are eligible for the reduced-rate<br />
subscriptions to the print version <strong>of</strong> Toxicological<br />
Sciences and other toxicology journals. Members also<br />
receive other printed publications <strong>of</strong> the <strong>Society</strong><br />
including the Annual Meeting <strong>Program</strong> and the<br />
Membership Directory.<br />
Utilize the On-Line Directory<br />
Members have said this is one <strong>of</strong> their most-used<br />
resources. You can search by city, state, country,<br />
specialty section, or regional chapter as well as<br />
member name.<br />
Join a Specialty Section<br />
Choose from 20 SOT Specialty Sections, which<br />
provide forums for networking and exchanging<br />
information with peers who share an interest in your<br />
area <strong>of</strong> toxicology. The annual receptions and meetings<br />
<strong>of</strong> the Specialty Sections at the Annual Meeting are<br />
ideal opportunities to network with colleagues. Dues<br />
for Specialty Section membership are $15.<br />
SPECIAL OFFER to non-member SOT 2005<br />
Annual Meeting attendees: Apply by<br />
May 1, 2005 for membership and SOT will<br />
waive your 2005 dues.<br />
Easy on-line membership application takes<br />
approximately 15 minutes to complete.<br />
www.toxicology.org<br />
Be a part <strong>of</strong> the leading global force and<br />
resource for advancing toxicology!<br />
Participate in Your Regional SOT Chapter<br />
Join one <strong>of</strong> eighteen Regional Chapters that foster<br />
scientific exchange at a local level, organize regular<br />
local meetings throughout the year, and sponsor<br />
awards. Each chapter has a Web site, which is<br />
accessible at www.toxicology.org.<br />
Utilize Career Resource and Development<br />
Services<br />
Take advantage <strong>of</strong> SOT’s on-line service that provides<br />
a year-round mechanism for linking job candidates<br />
with employment positions in toxicology and related<br />
biological sciences.<br />
Nominate for Awards<br />
Consider nominating a fellow toxicologist or student<br />
for an award. SOT has simplified the process <strong>of</strong><br />
nominating candidates for SOT Sponsored Awards<br />
through the Awards Nomination On-Line system.<br />
Participate on an SOT Committee or<br />
Activity<br />
Volunteer to serve on an SOT Committee. Nominations<br />
for SOT Councilors and Officers come from those who<br />
have served on committees.<br />
Find Products and Services<br />
Visit toxexpo.com, the year-round resource for all your<br />
scientific product and service needs.<br />
Receive Reduced Registration Costs for<br />
Future Annual Meetings<br />
You will be able to register at reduced rates for future<br />
years. The 2006 SOT Annual Meeting will be in San<br />
Diego, CA.<br />
Visit the SOT Membership Booth<br />
across from the Exhibit Hall entrance<br />
We’ll see you at the Annual Meeting in New Orleans!<br />
For complete information about membership in the <strong>Society</strong> <strong>of</strong> <strong>Toxicology</strong>, visit the<br />
Membership Booth at the Annual Meeting or go to the SOT Web site,<br />
www.toxicology.org, and select Member Services. Look for the link to Membership<br />
Information.<br />
266 SOT's 44 th Annual Meeting
44 th Annual Meeting & ToxExpo TM<br />
March 6–10, 2005
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