Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo General Information (Continued) GENERAL INFO Speaker Ready Room Ernest N. Morial Convention Center, 202 Saturday .................................................................4:00 PM–7:00 PM Sunday .................................................................. 7:00 AM–5:30 PM Monday–Wednesday .......................................... 7:00 AM–5:00 PM Thursday ............................................................ 7:00 AM–11:30 AM Meeting Courtesy Policy The use of photographic equipment is prohibited in all scientific sessions. Please contact Show Management, Libby Jones, for permission to take pictures in the Exhibit Hall. In addition, please turn off sound on all cellular phones while attending scientific sessions. Note that the entire Ernest N. Morial Convention Center is a smoke-free environment. SOT Memorabilia Shirts, portfolios and other items customized for SOT are available for ordering on-line for pick-up at the Annual Meeting. Visit the SOT Web site’s 2005 Annual Meeting Section (www.toxicology.org) for full details. Career Resource and Development Services SOT’s on-line job bank makes it easy for candidates and employers alike to access the Career Resource and Development Service from the main SOT Web site at www.toxicology.org throughout the year. Registrations are continuously processed and valid for six months. Once registered, candidates may search the listing of available jobs and employers may browse candidate profiles. During the registration period, users can update their listings or search the database as often as they wish. Communication with a desired employer or candidate can even be made via e-mail messages created within the system. The Career Resource and Development Center is an important part of the Annual Meeting, providing a coordinated service for information regarding career opportunities and qualified candidates. Please do your job and candidate searches before you arrive at the meeting. Access to the SOT job bank Web site in the Career Resource and Development Center will be limited to the availability of 4 computers at the meeting. Employers and candidates will have access to computers, but computer use will be restricted to short searches for updates or new information. Although pre-registration is encouraged, registrations will be accepted at the Annual Meeting. SOT Student Members who register for the Career Resource and Development Service before the SOT Annual Meeting will not be charged the $20 on-site registration fee. Please note that you must be a Student Member of SOT to register in this category. All users with current registrations at the time of the Annual Meeting will be permitted to use the service. For additional information contact Nichelle Sankey at SOT Headquarters; (703) 438-3115 or nichelle@toxicology.org. 26 SOT's 44 th Annual Meeting
2005 Award Winners The Society of Toxicology presented the following awards for the year 2005: Arnold J. Lehman Award Rory Conolly Dr. Rory B. Conolly’s contributions as a leader in the incorporation of good science in risk assessment and regulatory decisions are consistent with the spirit of the Arnold J. Lehman Award. He has had a significant influence on many important risk assessment decisions and documents within the U.S. government and industry. Even more importantly, his knowledge plus his communication skills have created a lasting appreciation by many of his “students” for the importance of computational biology methods in the field of risk assessment. Dr. Conolly’s experience with physiologically-based pharmacokinetic modeling has resulted in his being widely sought by governmental, industrial, and academic organizations to design and interpret studies involving the science of non-cancer risk assessment and cancer risk assessment modeling. He has provided expert testimony before Congress, participated in the preparation of several water quality criteria monographs for EPA, and has conducted risk assessment activities on behalf of NIOSH, NIEHS, IPCS, FDA and the SOT. Dr. Conolly stands out among his colleagues as a leader in the inclusion of good science in risk assessment. Board of Publications Award in Toxicological Sciences The Board of Publications has unanimously selected the paper entitled Arsenic Stimulates Angiogenesis and Tumorigenesis In Vivo as the best paper published in Toxicological Sciences during the past year. The joint first authors of this paper are Nicole V. Soucy and Michael A. Ihnat. The co-authors are Chandrashekhar D. Kamat, Linda Hess, Mark J. Post, Linda R. Klei, Callie Clark and Aaron Barchowsky (ToxSci. 76, 271–279, 2003). Although arsenicals have been used for treating a variety of cancers including acute or chronic leukemias and solid tumors, their clinical use and environmental exposures are also associated with significant adverse effects on the cardiovascular system. One hypothesis for the antitumor effects of trivalent arsenic As (III) is that it inhibits angiogenesis. At the same time, however, there is conflicting evidence that As (III) is also directly angiogenic in cell culture. The significance of the work reported by Soucy et al. is that the paper represents the first report of the effects of As (III) on angiogenesis in vivo. The authors used both avian and mammalian models to test the hypothesis that As (III) stimulated angiogenesis and tumor growth in a dose-dependent manner. The authors showed that As (III) increased blood vessel density in the chick chorioallantoic membrane and mouse Matrigel models. Additionally, they demonstrated that As (III) increased the size and density of blood vessels of solid tumors growing in a nude mouse model while enhancing tumor growth and metastatic potential. Importantly, the authors’ work revealed a complex, non-linear dose-response relationship, with pro-angiogenic properties observed at levels relevant to environmental exposure. Although the work has not fully characterized the mechanisms underlying the angiogenic properties of As (III), the results represent important new data that impact human health. In particular, the work provides new information regarding the scientific underpinning of the carcinogenicity of As (III) and the potential for adverse health effects of environmental exposure to As (III) while documenting a very narrow therapeutic window when treating solid tumors with arsenic. The paper is an outstanding example of a relevant, hypothesis-driven approach to address an important human health concern. Contributions to Public Awareness of Animal Welfare Award This year, the Awards Committee has selected two recipients for Contributions to the Public Awareness of the Importance of Animals in Toxicology Research Award. FBR, Frankie L. Trull, President Orrin G. Hatch The first recipient is the Foundation for Biomedical Research, which has provided valuable educational resources supporting the use of animals systems for providing invaluable and irreplaceable insights into human systems. These resources include articles elaborating the contributions of animal research, materials for both teachers and parents of children in primary and secondary schools, and links to other federal agencies and foundation web sites that support and address the needs of animals in biomedical research. The second recipient is Senator Orrin Hatch, a long-time supporter of biomedical research. Senator Hatch, as Chair of the Senate Judiciary Committee has held hearings on the subject of “Animal Rights: Activism vs. Criminality” to call attention to the rising incidence of terrorist like activities associated with some animal rights group. He will hold another committee meeting on the topic of Animal Rights/Activism in late 2004 or early 2005 with the intent of initiating legislation to protect universities and research organizations from such groups’ illegal and violent activities. AWARDS up-to-date information at www.toxicology.org 27
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Program - Society of Toxicology

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