Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1732 PROTEIN PROFILING OF ANTIANDROGEN EFFECTS IN THE ADULT RAT VENTRAL PROSTATE. C. Cayatte 1,3 , C. Pons 1 , J. Guigonis 2 , P. Kennel 3 , D. Rouquie 3 , R. Bars 3 , B. Rossi 1 and M. Samson 1 . 1 Unit 638, INSERM, Nice, France, 2 IFR50 Proteomic platform, INSERM, Nice, France and 3 Research Center, Bayer CropScience, Sophia- Antipolis, France. Sponsor: N. Carmichael. #1733 THE ENDOCRINE PROFILE OF INTACT FEMALE RATS ON THE DAY OF PROESTRUS FOLLOWING EXPOSURE TO ATRAZINE. R. L. Cooper, A. Buckalew, S. C. Laws and T. E. Stoker. RTD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1734 ESTROGENICITY OF MIXTURES OF CHEMICALS ON UTERINE GROWTH OF PREPUBERAL RATS. J. V. Meeuwen 1 , A. Piersma 2 , M. van den Berg 1 and J. Sanderson 1 . 1 Biotoxicology, IRAS, Utrecht, Netherlands and 2 RIVM, Bilthoven, Utrecht, Netherlands. #1735 MOLECULAR CHARACTERIZATION OF THE UTEROTROPHIC ASSAY: TEMPORAL GENE EXPRESSION CHANGES IN THE UTERUS FOLLOWING ETHINYLESTRADIOL. H. J. Ahr, H. Ellinger-Ziegelbauer, A. Freyberger, E. Hartmann, A. Mahringer and F. Kroetlinger. Molecular and Genetic Toxicology, Bayerhealthcare AG, Wuppertal, Germany. #1736 COMPARATIVE GENE EXPRESSION ANALYSIS OF THE MOLECULAR EFFECTS OF SYNTHETIC, PLANT-DERIVED AND PHYSIOLOGICAL ESTROGENS IN THE IMMATURE RODENT UTERUS. J. G. Moggs, H. Tinwell, F. Lim, M. J. David, I. Kimber, J. Ashby and O. George. Syngenta CTL, Macclesfield, Cheshire, United Kingdom. #1737 ESTRADIOL PROTECTS AGAINST ETHANOL- INDUCED BONE LOSS IN FEMALE RATS BY PREVENTING OSTEOCLAST ACTIVATION. R. Haley 2 , M. Hidestrand 1,2 , K. Shankar 1,2 , C. K. Lumpkin 3 , B. Yarberry 2 , T. M. Badger 4,2 and M. J. Ronis 1,2 . 1 Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 2 Arkansas Children’s Nutrition Center, Little Rock, AR, 3 Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR and 4 Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR. #1738 ONTOGENY OF P-GLYCOPROTEIN (PGP) IN SELECTED TISSUES OF NEONATAL MALE AND FEMALE CD-1 MICE. S. Yavanhxay 1 , M. Christian 2 , A. Hoberman 2 , J. C. Eldridge 1 and J. T. Stevens 1 . 1 Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC and 2 Charles Rivers Labs, Horsham, PA. #1739 TRANSCRIPT PROFILING OF GENE EXPRESSION CHANGES ASSOCIATED WITH AN INCREASED INCIDENCE OF CANCER AFTER EXPOSURE OF NEONATAL MICE TO XENOESTROGENS. D. J. Moore, F. Lim, H. Tinwell, I. Kimber, J. Ashby, G. Orphanides and J. Moggs. Syngenta CTL, Macclesfield, Cheshire, United Kingdom. #1740 THYROID HORMONE STATUS IN ADULT FEMALE RATS AFTER AN ORAL DOSE OF PERFLUOROOCTANESULFONATE (PFOS). J. Butenhoff 1 , M. Eastvold 2 , J. Bjork 3 , D. Ehresman 1 , R. Singh 2 , K. Wallace 3 and S. Tanaka 1 . 1 3M Company, St. Paul, MN, 2 Mayo Medical Laboratories, Rochester, MN and 3 University of Minnesota, Duluth, MN. #1741 THE EFFECTS OF POLYCHLORINATED BIPHENYLS ON THYROID HORMONE RECEPTOR MEDIATED ACTION IN VIVO AND IN VITRO. K. J. Gauger, S. Giera and R. Zoeller. Biology Department, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA. #1742 COMPARISON OF INHIBITORY EFFECTS OF ETHANOL AND METHYL T-BUTYL ETHER (MTBE) ON RAT LEYDIG CELL TESTOSTERONE PRODUCTION. R. Shuto, B. B. Goldberg and A. de Peyster. Graduate School of Public Health, San Diego State University, San Diego, CA. #1743 CHANGES IN FETAL TESTIS GENE EXPRESSION AND STEROID HORMONE SYNTHESIS INDUCED IN MALE OFFSPRING AFTER MATERNAL TREATMENT WITH DEHP (DI-N-ETHYLHEXYL PHTHALATE). V. S. Wilson 1 , C. Lambright 1 , J. Furr 1 , K. Bobseine 1 , C. Wood 1 , K. Hosdeshell 2 and L. E. Gray 1 . 1 Reproductive Toxicology Division, U.S. EPA, ORD, NHEERL, Research Triangle Park, NC and 2 NC State University, Raleigh, NC. #1744 MECHANISM OF PHTHALATE-INDUCED DEVELOPMENTAL REPRODUCTIVE TOXICITY: INHIBITION OF TESTOSTERONE AND INSULIN-LIKE 3 HORMONE PRODUCTION BY FETAL LEYDIG CELLS. L. E. Gray, N. Noriega, C. Lambright, J. Furr and V. S. Wilson. ORD, NHEERL, RTD, EB, U.S. EPA, Research Triangle Park, NC. #1745 REPRODUCTIVE SUCCESS AND AROMATASE ACTIVITY IN THE FISH CUNNER (TAUTOGOLABRUS ADSPERSUS) EXPOSED TO ATRAZINE OR OCTYLPHENOL IN THE LABORATORY. L. J. Mills 1 , R. E. Gutjahr-Gobell 1 , S. C. Laws 2 , D. Borsay Horowitz 1 and G. E. Zaroogian 1 . 1 U.S. EPA, NHEERL, Atlantic Ecology Division, Narragansett, RI and 2 U.S. EPA, NHEERL, Reproductive Toxicology Division, Research Triangle Park, NC. #1746 AROMATASE INHIBITION: LINKING BIOCHEMICAL MECHANISM OF ACTION TO OUTCOME IN THE SHORT-TERM FATHEAD MINNOW REPRODUCTION ASSAY. D. L. Villeneuve, K. M. Jensen, M. D. Kahl, E. J. Durhan, E. A. Makynen, A. L. Linnum, B. C. Butterworth and G. T. Ankley. Mid-Continent Ecology Division, U.S. EPA, Duluth, MN. Sponsor: J. Mata. 182 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1747 EFFECTS OF VARIOUS LACTONE- DERIVATIVES ON AROMATASE (CYP19) ACTIVITY IN H295R HUMAN ADRENOCORTICAL CARCINOMA CELLS AND (ANTI)ANDROGENICITY IN TRANSFECTED LNCAP HUMAN PROSTATE CANCER CELLS. T. Sanderson 1 , S. Nijmeijer 1 , D. Scholten 1 , M. van den Berg 1 , S. Cowell 2 , E. Guns 2 , C. Nelson 2 and S. Ruchirawat 3 . 1 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, NL, Netherlands, 2 The Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada and 3 Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok, Thailand. #1748 IN VITRO EFFECTS OF BROMINATED FLAME RETARDANTS ON THE ADRENOCORTICAL ENZYME CYP17. A NOVEL ENDOCRINE MECHANISM OF ACTION? R. Fernandez Canton 1 , T. Sanderson 1 , S. Nijmeijer 1 , A. Bergman 2 and M. van den Berg 1 . 1 Institute for Risk Assessment Sciences, IRAS, Utrecht, Netherlands and 2 Department of Environmental Chemistry and Analytical Chemistry. Stockholm University, Stockholm, Sweden. #1749 ESTROGENIC ACTIVITY OF THE POLYBROMINATED DIPHENYL ETHERS FLAME RETARDANTS. M. Mercado Feliciano 1 and R. M. Bigsby 2 . 1 Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN and 2 Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN. Sponsor: L. Kamendulis. #1750 SCREENING ASSAYS FOR ANDROGENIC ACTIVITIES OF XENOBIOTICS. S. O. Mueller and S. Simon. Toxicology, Merck KGaA, Darmstadt, Germany. #1751 EVALUATION OF POTENTIAL ESTROGENIC AND ANDROGENIC ACTIVITY OF OCTAMETHYLCYCLOTETRASILOXANE (D4) AND DECAMETHYLCYCLOPENTASILOXANE (D5). A. L. Quinn, S. D. Crofoot, J. M. Tobin, J. M. Regan, J. M. McMahon and K. P. Plotzke. Dow Corning Corporation, Midland, MI. #1752 ESTROGENIC ENDOCRINE DISRUPTOR POTENCY OF ORGANOCHLORINE PESTICIDES DETECTED USING THE LUMI- CELL TM ER BIOASSAY. J. D. Gordon 1 , A. C. Chu 1 , M. D. Chu 2 , M. S. Denison 3 and G. C. Clark 1 . 1 Xenobiotic Detection Systems, Inc., Durham, NC, 2 Alta Analytical PerspectivesInc., Wilmington, NC and 3 Department of Environmental Toxicology, University of California, Davis, Davis, CA. #1753 SENSITIVE METHOD FOR DETERMINING PESTICIDE ESTROGENIETY AT PICOMOLAR LEVELS USING A SERUM-FREE BG-1 OVARIAN CELL MODEL. P. Wong and F. Matsumura. Ctr for Health and the Environment, UC Davis, Davis, CA. #1754 GENE EXPRESSION PATTERNS OF THE AMPHIBIAN HPT-AXIS IN NORMAL DEVELOPMENT AND AFTER EXPOSURE TO THE MODULATORS METHIMAZOLE, PERCHLORATE AND PROPYLTHIOURACIL. J. J. Korte, H. M. Kerr, S. L. Batterman, G. W. Holcombe, P. A. Kosian, J. E. Tietge and S. J. Degitz. MED, NHEERL, ORD, U.S. EPA, Duluth, MN. Sponsor: J. Nichols. #1755 PROTEIN PROFILING OF XENOPUS LAEVIS BRAIN CELLS FOLLOWING EXPOSURE TO T4 SYNTHESIS INHIBITORS: POTENTIAL APPLICATION TO THE ASSESSMENT/DIAGNOSIS OF XENOBIOTICS THAT PERTURB THE THYROID PATHWAY. J. Serrano 1 , B. Witthuhn 2 , L. Higgings 2 , J. Tietge 1 , J. Korte 1 , P. Kosian 1 , G. Holcombe 1 and S. Degitz 1 . 1 ORD/NHEERL/MED, U.S. EPA, Duluth, MN and 2 Biochemistry and Molecular Biology, University of Minnesota, St. Paul, MN. Sponsor: J. Nichols. #1756 PHENOBARBITAL AFFECTS THYROID HISTOLOGY AND LARVAL DEVELOPMENT IN THE AFRICAN CLAWED FROG, XENOPUS LAEVIS. M. J. Chowdhury, G. W. Holcombe, P. A. Kosian, J. E. Tietge and S. J. Degitz. Mid-Continent Ecology Division, U.S. EPA, Duluth, MN. Sponsor: J. Nichols. #1757 SUBLETHAL EFFECTS OF CADMIUM ON DEVELOPMENT IN RANA PIPIENS AND XENOPUS TROPICALIS. J. A. Gross 1,2 , T. Chen 2 and W. H. Karasov 2 . 1 Animal Sciences, University of Wisconsin–Madison, Madison, WI and 2 Wildlife Ecology, University of Wisconsin–Madison, Madison, WI. #1758 MECHANISMS OF GERMINAL VESICLE BREAKDOWN (GVBD) INHIBITION BY PHENYL-SUBSTITUTED GLYCOL ETHERS IN XENOPUS OOCYTES IN VITRO. D. J. Fort 1 , R. L. Rogers 1 , J. H. Thomas 1 , P. D. Guiney 2 and J. A. Weeks 2 . 1 Fort Environmental Laboratories, Stillwater, OK and 2 Product Safety & Environmental Assessment, SC Johnson & Son, Racine, WI. #1759 NON-ADDITIVE DOSE DEPENDENT GENE EXPRESSION PATTERNS EXHIBITED BY A MIXTURE OF 17-ALPHA ETHYNYLESTRADIOL AND GENISTEIN IN VIVO. R. Gupta 2,3,4 , L. D. Burgoon 1,3,4 , A. Harney 2,3,4 , D. R. Boverhof 2,3,4 , J. Kwekel 2,3,4 , C. Gennings 5 and T. R. Zacharewki 2,3,4 . 1 Pharmacology & Toxicology, Michigan State University, East Lansing, MI, 2 Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 3 Center for Integrative Toxicology, Michigan State University, East Lansing, MI, 4 National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI and 5 Biostatistics, Virginia Commonwealth University, Richmond, VA. WEDNESDAY up-to-date information at www.toxicology.org 183
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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