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44 th Annual Meeting and ToxExpo Program Description THURSDAY #2174 INVESTIGATION OF SKIN BARRIER CREAMS FOR LOWERING PENETRATION OF JP-8 JET FUEL THROUGH IN VITRO PIG SKIN. J. J. Schlager 1 , D. L. Pollard 2 , T. A. Minnick 1 , A. J. Guilfoil 1 and S. C. Stevens 1 . 1 HEPB, Applied Biotechnology Branch, Air Force Research Laboratory, Dayton, OH and 2 ManTech Environmental Technologies, Inc., Dayton, OH. #2175 EFFECT OF ACUTE AND CHRONIC EXPOSURE TO THE CLEANSER, TRICHLOROETHYLENE, ON THE DERMAL ABSORPTION OF THE BIOCIDE TRIAZINE. J. L. Yeatts, R. E. Baynes, J. D. Brooks, B. M. Barlow and J. E. Riviere. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #2176 EFFECT OF IN VIVO JET FUEL EXPOSURE ON SUBSEQUENT IN VITRO DERMAL ABSORPTION OF AROMATIC AND ALIPHATIC HYDROCARBONS. F. Muhammad 1 , N. A. Monteiro- Riviere 2 , R. E. Baynes 2 and J. E. Riviere 2 . 1 University of Agriculture, Faisalabad, Pakistan and 2 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #2177 ABSORPTION OF LAWSONE THROUGH HUMAN SKIN. M. E. Kraeling 1 , C. T. Jung 2 and R. L. Bronaugh 1 . 1 Office of Cosmetics and Colors, U.S. FDA, Laurel, MD and 2 Office of Pharmaceutical Science, U.S. FDA, Rockville, MD. #2178 SKIN PENETRATION OF BREAK-FREE CLP IN THREE SPECIES; SPRAGUE DAWLEY RAT, CD- 1 MOUSE, AND YORKSHIRE PIG. C. M. Garrett and J. N. McDougal. Pharmacology/Toxicology, Wright State University, Dayton, OH. #2179 CHANGES IN GENE EXPRESSION IN RAT EPIDERMIS AFTER JET FUEL (JP-8) EXPOSURE TO THE SKIN. C. M. Amato, C. M. Garrett and J. N. McDougal. Pharmacology/Toxicology, Wright State University, Dayton, OH. #2180 PROTEOMIC ANALYSIS OF JP-8 JET FUEL EXPOSURE IN HUMAN KERATINOCYTE CELL CULTURE. F. Witzmann 1 , N. Monteiro-Riviere 2 , A. Inman 2 , N. Pedrick 1 , H. Ringham 1 and J. Riviere 2 . 1 Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN and 2 Center for Chemical Toxicology Research & Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC. #2181 EXPRESSION PROFILING OF HUMAN EPIDERMAL KERATINOCYTE RESPONSE FOLLOWING JP-8 EXPOSURE. C. Chou 1 , J. Yang 2 , N. A. Monteiro-Riviere 3 and J. J. Chen 4 . 1 Department of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan, 2 Department of Dermatology, Chung-Shan Medical University Hospital, Taichung, Taiwan, 3 Center for Cutaneous Toxicology and Research Pharmacokinetics, North Carolina State University, Raleigh, NC and 4 Institute of Molecular Biology, National Chung-Hsing University, Taichung, Taiwan. #2182 JP-8 JET FUEL EXPOSURE INDUCES INFLAMMATORY CYTOKINES IN RAT SKIN. R. Gallucci 1 , S. K. O’Dell 1 , D. Faulkner 1 and L. D. Fechter 2 . 1 Pharmaceutical Sciences, OU Health Sciences Center, Oklahoma City, OK and 2 Jerry Pettis Memorial Veterans Medical Center, Loma Linds, CA. #2183 PROTEOMIC ANALYSIS OF NANOPARTICLE EXPOSURE IN HUMAN KERATINOCYTE CELL CULTURE. N. A. Monteiro-Riviere 1 , Y. Y. Wang 2 , S. M. Hong 3 , A. O. Inman 1 , R. J. Nemanich 2 , J. Tan 3 , F. A. Witzmann 3 and J. E. Riviere 1 . 1 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, 2 Department of Physics, North Carolina State University, Raleigh, NC and 3 Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN. #2184 NANTOTUBE DISPERSAL IN HUMAN KERATINOCYTE CELL CULTURE USING SURFACTANTS. A. O. Inman 1 , Y. Y. Wang 2 , R. J. Nemanich 2 , J. E. Riviere 1 and N. A. Monteiro-Riviere 1 . 1 Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC and 2 Department of Physics, North Carolina State University, Raleigh, NC. #2185 LOCALIZATION OF INTRADERMALLY INJECTED QUANTUM DOT NANOPARTICLES IN REGIONAL LYMPH NODES. D. W. Roberts 1 , N. V. Gopee 1 , B. J. Miller 1 , D. Norton 2 , A. R. Warbritton 2 , J. R. Bucher 3 , W. W. Yu 4 , C. M. Sayes 4 , V. L. Colvin 4 and P. C. Howard 1 . 1 Biochemical Toxicology, NCTR, Jefferson, AR, 2 Pathology, Charles River Co., Jefferson, AR, 3 National Toxicology Program, NIEHS, Research Triangle Park, NC and 4 Center for Biological and Environmental Nanotechnology, Rice University, Houston, TX. #2186 IMAGING THE PENETRATION OF RUBPY- DOPED SILICA NANOPARTICLES INTO HUMAN AND MOUSE SKIN WITH FLUORESCENT MICROSCOPY. S. C. Wasdo, S. M. Roberts, S. Santra, J. Munson and Y. Song. University of Florida, Gainesville, FL. #2187 MODULATORY EFFECTS OF SUBCHRONIC EXPOSURE TO SIMULATED SOLAR LIGHT ON TATTOOED SKIN IN SKH-1 MICE. N. V. Gopee 1,2 , Y. Cui 1,2 , G. R. Olson 3 , A. R. Warbritton 3 , B. J. Miller 1,2 , L. H. Couch 1,2 , W. G. Wamer 4 and P. C. Howard 1,2 . 1 NCTR, U.S. FDA, Jefferson, AR, 2 NTP Center for Phototoxicology, NCTR, U.S. FDA, Jefferson, AR, 3 Charles River Co., Jefferson, AR and 4 CFSAN, U.S. FDA, College Park, MD. #2188 ROLE OF VITAMIN E IN THE ANTIOXIDANT DEFENSE SYSTEM OF SKIN IN YOUNG AND OLD MICE EXPOSED TO CUMENE HYDROPEROXIDE. A. R. Murray 1 , E. Kisin 2 , K. Kawai 3 , V. E. Kagan 3 , C. Kommineni 2 , V. Castranova 1,2 and A. A. Shvedova 1,2 . 1 Physiology and Pharmacology, WVU, Morgantown, WV, 2 PPRB, NIOSH, Morgantown, WV and 3 University of Pittsburgh, Pittsburgh, PA. 216 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #2189 DETECTION OF BENZO(A)PYRENE-INDUCED DNA DAMAGE IN THE SKIN OF CD-1 MICE USING THE COMET ASSAY. J. W. Parton, Y. Xu and J. K. Kerzee. MicaGenix, Inc., Greenfield, IN. #2190 EFFECT OF METHYL SUBSTITUTION OF BENZENE ON THE PERCUTANEOUS ABSORPTION AND SKIN IRRITATION HAIRLESS RATS. J. Ramapuram 1 , E. AHAGHOTU 1 and M. SINGH 1 . 1 Florida A&M University, Tallahassee, FL and 2 SOT, E\TEST, AL. #2191 LONG TERM REPRODUCIBILITY OF EPIDERM TM , AN EPIDERMAL MODEL FOR DERMAL TESTING AND RESEARCH. M. Klausner, J. Kubilus, J. E. Sheasgreen and P. J. Hayden. MatTek Corporation, Ashland, MA. #2192 DETERMINING SKIN IRRITATION POTENTIAL OF INDUSTRIAL FLUIDS IN HUMANS USING TRANS-EPIDERMAL WATER LOSS (TEWL). M. Wragg 1 and S. Signs 2 . 1 Lubrizol Limited, Derby, United Kingdom and 2 The Lubrizol Corporation, Wickliffe, OH. #2193 EVALUATION OF HISTORICAL POSITIVE CONTROL DATA FOR RESPONSE CONSISTENCY AND REDUCTION IN ANIMAL USE IN PHOTOTOXICITY AND PHOTOALLERGY ASSESSMENTS. D. B. Learn, C. P. Sambuco, M. Arocena, M. L. Davis, T. S. Coston, P. D. Forbes and A. M. Hoberman. Center for Photobiology, Charles River Discovery and Development Services, Argus Division, Horsham, PA. #2194 QUANTIFICATION OF MIXTURE INTERACTIONS ON DERMAL PERMEABILITY–A SOLVATOCHROMATIC APPROACH. R. E. Baynes, B. M. Barlow, X. R. Xia, J. L. Yeatts, J. D. Brooks and J. E. Riviere. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #2195 PREDICTING HUMAN SKIN ABSORPTION OF CHEMICALS: DEVELOPMENT OF A NOVEL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP. W. Luo 1 , S. Medrek 2 , H. Nguyen 1 and W. Fung 1 . 1 Toxicology, L’Oreal USA, Clark, NJ and 2 Department of Chemical Engineering, Princeton University, Princeton, NJ. #2196 A NOVEL SYSTEM COEFFICIENT APPROACH FOR QUANTITATIVE ASSESSMENT OF DERMAL ABSORPTION FROM CHEMICAL MIXTURES BY USING THE MEMBRANE- COATED FIBER TECHNIQUE. X. R. Xia, R. E. Baynes, N. A. Monteiro-Riviere and J. E. Riviere. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #2197 PREDICTION OF DERMAL ABSORPTION OF CHEMICAL MIXTURES USING BOTH PENETRANT AND MIXTURE COMPONENT PROPERTIES IN A HYBRID QUANTITATIVE STRUCTURE PERMEABILITY RELATIONSHIP (QSPR). J. E. Riviere and J. D. Brooks. Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC. #2198 COMPUTER-CONTROLLED SYSTEM FOR GENERATION OF CHEMICAL VAPORS IN IN VITRO DERMAL UPTAKE STUDIES. M. Rauma and G. Johanson. Work Environment Toxicology, Karolinska Institutet, Stockholm, Sweden. #2199 CAN CHRONIC SKIN IRRITATION BE PREDICTED BY AN ACUTE TEST? C. M. de Jongh, J. J. Jacobs, S. Kezic and M. M. Verberk. Coronel Institute for Occupational and Environmental Health, AMC, University of Amsterdam, Amsterdam, Netherlands. Sponsor: P. Boogaard. #2200 ANTI-PSORIASIS MODEL IN THE MOUSE. S. Rowton and P. Long. Covance Laboratories Ltd., Harrogate, United Kingdom. Sponsor: D. Everett. #2201 EVALUATION OF THE TOXICITY OF MEDICAL COUNTERMEASURES FOR SULFUR MUSTARD. D. M. Moore 1 , R. C. Kiser 1 , N. A. Niemuth 1 , B. M. Biddle 1 , M. C. Babin 1 , I. Koplovitz 2 and W. J. Smith 2 . 1 2 Battelle Memorial Institute, Columbus, OH and US Army Medical Reasearch Institute of Chemical Defense, Aberdeen, MD. #2202 MOUSE EAR VESICANT MODEL (MEVM) EVALUATION OF TREATMENT COMBINATIONS AGAINST TOPICAL SULFUR MUSTARD CHALLENGE. R. C. Kiser 1 , D. M. Moore 1 , N. A. Niemuth 1 , B. M. Biddle 1 , M. C. Babin 1 , R. P. Casillas 1 , I. Koplovitz 2 and W. J. Smith 2 . 1 Battelle Memorial Institute, Columbus, OH and 2 US Army Medical Research Institute of Chemical Defense, Aberdeen, MD. #2203 90-DAY SUBCHRONIC DERMAL TOXICITY OF INSECT REPELLENT SS-220I IN RATS. J. T. Houpt and G. J. Leach. US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD. Thursday Morning, March 10 8:30 AM to 11:30 AM La Louisiane Ballroom B POSTER SESSION: GENOTOXICITY Chairperson(s): Martha M. Moore, U.S. FDA, Jefferson, AR. Displayed: 8:30 AM–11:30 AM Attended: 10:00 AM–11:30 AM #2204 DATABASE CONSOLIDATION BASED ON TOXML OF GENETIC TOXICITY DATA SUBMITTED TO CFSAN/OFAS AND CDER. J. Mayer 1 , M. Cheeseman 1 , C. Nelson 1 , R. Benz 2 , E. Matthews 2 , N. Kruhlak 2 , J. Contrera 2 , M. Twaroski 1 , K. Arvidson 1 and C. Yang 3 . 1 CFSAN/OFAS, U.S. FDA, College Park, MD, 2 CDER/OPS/ICSAS, U.S. FDA, Rockville, MD and 3 Leadscope, Inc., Columbus, OH. THURSDAY up-to-date information at www.toxicology.org 217
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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