Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #260 DEVELOPMENTAL EXPOSURE TO ENVIRONMENTAL ESTROGENS IS ASSOCIATED WITH OBESITY LATER IN LIFE. E. Padilla-Banks 1 , W. Jefferson 1,2 , R. Snyder 2 and R. Newbold 1 . 1 Laboratory of Molecular Toxicology, NIEHS, NIH/DHHS, Research Triangle Park, NC and 2 Molecular and Evironmental Toxicology Department, NC State University, Raleigh, NC. #261 PHYSIOLOGICAL PARAMETERS FOR EARLY LIFE STAGES. S. Olin 1 , H. Clewell 2 , R. Gentry 2 and I. Working Group 1 . 1 Risk Science Institute, International Life Sciences Institute, Washington, DC and 2 ENVIRON Health Sciences Institute, Ruston, LA. #262 NON-CLINICAL RODENT PEDIATRIC STUDIES AT CTBR: ASSESSMENT OF MORTALITY AND GROWTH. L. Pouliot, L. Pinsonneault, M. Adamo and K. Robinson. Toxicology, CTBR, Senneville, QC, Canada. Sponsor: M. Vezina. #263 AGE-RELATED DIFFERENCES IN SUSCEPTIBILITY TO TOXIC EFFECTS OF VALPROIC ACID IN RATS. P. Espandiari, T. Miller, A. Knapton, J. Zhang and J. Hanig. CDER, U.S. FDA, Silver Spring, MD. #264 ASSESSMENT OF HAZARD POTENTIAL AND RISK FOR ASTHMATIC RESPONSES FOLLOWING RESIDENTIAL EXPOSURE TO PHTHALATES. R. McKee, R. David, J. H. Butala, R. Parod and L. Navarro. Phthalate Esters Panel, Washington, DC. #265 BENZYL ALCOHOL: SAFETY ASSESSMENT IN JUVENILE RATS. O. Foulon, L. Mungapen, W. Gaoua and R. Forster. CIT, Evreux, France. #266 LIPID PEROXIDATION PRODUCT INDUCED GASTRIC GROWTH IN POSTNATAL RATS BY MODULATION OF SELECTED PROTEIN KINASES. P. C. Lee 1,2 . 1 Pediatrics, Medical College of Wisconsin, Milwaukee, WI and 2 Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI. #267 GENE EXPRESSION PROFILES OF THE ARTICULAR CARTILAGE IN JUVENILE RATS TREATED WITH THE QUINOLONE ANTIBACTERIAL AGENT OFLOXACIN. K. Goto 1 , K. Yabe 1 , S. Takada 1 , Y. Yamamoto 1 , H. Yokota 2 , T. Jindo 1 and K. Furuhama 1 . 1 Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd.,, Tokyo, Japan and 2 Proteome Research Laboratory, Daiichi Pharmaceutical Co., Ltd.,, Tokyo, Japan. #268 A NOVEL APPROACH TO GENERATE JUVENILE ANIMAL DATA DURING THE PRE/POSTNATAL RANGE FINDING STUDY IN THE RAT. L. M. De Schaepdrijver 1 , G. P. Bailey 1 , L. M. Burns 2 , J. Monbaliu 1 , P. Annaert 1 , T. P. Coogan 3 and W. Coussement 1 . 1 Johnson and Johnson Pharmaceutical Research & Development, Beerse, Belgium, 2 Sequani Limited, Ledbury, United Kingdom and 3 Johnson and Johnson Pharmaceutical Research and Development, Springhouse, PA. #269 IMPACT OF DOSE RATE ON NEUROTOXICITY OUTCOME IN CD RAT PUPS GIVEN THE N- METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST, MK-801. M. S. Marty, J. A. Hammond, A. J. Clark, D. Rick, J. Van Fleet, A. K. Andrus and J. P. Maurissen. Toxicology & Environmental Research, The Dow Chemical Company, Midland, MI. #270 COMPARATIVE DATA OF HAND-REARED AND MATERNALLY REARED INFANT CYNOMOLGUS MONKEYS FOR TOXICITY STUDIES. F. P. de Villa 1 , R. M. Perez 1 , T. Hayashi 1 , N. Muto 2 , M. Nomura 2 and H. Nakagawa 2 . 1 Ina Research Philippines, Inc., Binan Laguna, Philippines and 2 Ina Research Inc., Nagano, Japan. Monday Morning, March 7 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: DEVELOPMENTAL TOXICITY TESTING Chairperson(s): Christopher Lau, U.S. EPA, Research Triangle Park, NC and Gregg Cappon, Pfizer Global Research & Development, Groton, CT. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #271 INFLUENCE OF MATERNAL TOXICITY IN STUDIES ON DEVELOPMENTAL TOXICITY: A WORKSHOP REPORT. F. Welsch 1 and E. C. Hennes 2 . 1 Orbitox, Santa Fe, NM and 2 ECETOC, Brussels, Belgium. #272 TIME-MATED RABBITS WITH VASCULAR ACCESS PORT (VAP): A NOVEL APPROACH TO THE VASCULAR SYSTEM FOR SERIAL INFUSION OR REPETITIVE BLOOD COLLECTION. D. S. Broughton 1 , B. Fetter 2 , S. Fleener 1 and N. Frampton 2 . 1 Technical Services, CRP, Denver, PA and 2 SAD, CRP, Denver, PA. Sponsor: K. Williams. #273 EFFECTS OF FEED RESTRICTION ON EMBRYO-FETAL DEVELOPMENT IN RATS AND RABBITS. T. N. Lawrence, L. Tripp, M. S. Gilman, G. D. Cappon, M. E. Hurtt and T. L. Fleeman. Pfizer Global Research and Development, Groton, CT. #274 MICROARRAY-BASED ANALYSIS OF NUTRITION-ETHANOL INTERACTIONS DURING GESTATION. K. Shankar 1,3 , M. Hidestrand 1,3 , B. Yarberry 3 , R. Xiao 2,3 , F. A. Simmen 2,3 , T. M. Badger 2,3,1 and M. J. Ronis 1,3 . 1 Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, 2 Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR and 3 Arkansas Children’s Nutrition Center, Little Rock, AR. 68 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #275 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY OF DI-ISOHEPTYL PHTHALATE IN RODENTS. R. H. McKee 1 , K. L. Pavkov 1 , G. W. Trimmer 1 , L. H. Keller 2 and D. G. Stump 3 . 1 Toxicology & Environmental Sciences, ExxonMobil Biomedical Sciences, Inc., Annandale, NJ, 2 ExxonMobil Chemical Company, Houston, TX and 3 Wil Research Laboratories, Ashland, OH. #276 ASSESSING THE ROLE OF CYTOSOLIC PHOSPHOLIPASE A (CPLA 2 ) INHIBITION IN PHTHALATE ESTER TOXICITY. R. A. Clewell, S. M. Ross, K. W. Gaido and M. E. Andersen. CIIT Centers for Health Research, Research Triangle Park, NC. #277 MEDIUM CHAIN CHLORINATED PARAFFIN(MCCP)-INDUCED HAEMORRHAGIC LESIONS IN NEONATAL SPRAGUE-DAWLEY RATS. A ROLE FOR ALTERED VITAMIN K DISPOSITION? C. Elcombe 1 , B. Elcombe 1 , R. Powrie 1 , S. Barton 3 and D. Farrar 2 . 1 CXR Biosciences Ltd., Dundee, United Kingdom, 2 Ineos Chlor Ltd., Runcorn, United Kingdom and 3 Inveresk Research, Tranent, United Kingdom. #278 EFFECTS OF EXPOSURE TO 1- BROMOPROPANE IN GESTATION AND LACTATION PERIOD ON DAMS AND OFFSPRING IN RATS. K. Furuhashi 1 , H. Wang 1 , J. Kitoh 1 , H. Tsukamura 2 , K. Maeda 2 , Y. Takeuchi 1 and G. Ichihara 1 . 1 Nagoya University Graduate School of Medicine, Nagoya, Japan and 2 Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan. #279 L-THREO 3, 4-DIHYDROXYPHENYLSERINE (DOPS) TREATMENT DURING PERINATAL DEVELOPMENT DOES NOT ALTER THE IMPACT OF DIETARY COPPER DEFICIENCY IN MICE. J. Pyatskowit and J. R. Prohaska. University of Minnesota-Duluth, Duluth, MN. Sponsor: K. Wallace. #280 EFFECTS OF PERFLUOROOCTANOIC ACID EXPOSURE DURING PREGNANCY IN THE MOUSE. J. Thibodeaux, R. G. Hanson, J. M. Rogers and C. Lau. RTD, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #281 DEVELOPMENTAL TOXICITY OF 1-BUTANOL GIVEN TO RATS IN DRINKING WATER THROUGHOUT PREGNANCY. M. EMA 1 , H. Hara 2 , M. Matsumoto 1 , A. Hirose 1 and E. KAMATA 1 . 1 Risk Assessment, National Institute of Health Sciences, Tokyo, Japan and 2 Ina Research, Inc., Ina, Japan. #282 ASSESSMENT OF ISOBUTYL HEPTYL KETONE (IBHK) BY ORAL GAVAGE IN AN OECD 422 RAT REPRODUCTION/DEVELOPMENTAL SCREENING STUDY WITH SYSTEMIC AND NEUROLOGICAL ENDPOINTS. D. M. Wilson, E. W. Carney, C. L. Zablotny, B. L. Yano and T. J. Cawley. Dow Chemical, Midland, MI. #283 A REVIEW OF THE ROLE OF GENOTOXICITY IN THE DEVELOPMENTAL/REPRODUCTIVE TOXICITY OF AGROCHEMICALS. P. R. IYER 1 and D. W. Gammon 2 . 1 OEHHA/RCHAS, CALIFORNIA EPA, SACRAMENTO, CA and 2 CDPR, California EPA, Sacramento, CA. #284 DETERMINATION OF DART REFERENCE DOSES FOR WORKPLACE CHEMICAL EXPOSURES. C. J. Fields 1 , R. J. Parod 2 , T. A. Lewandowski 1 , C. A. Bradlee 2 , S. L. Jasti 2 and E. J. Kerfoot 2 . 1 Gradient Corporation, Seattle, WA and 2 BASF Corporation, Wynadotte, MI. #285 DEVELOPMENT OF QSAR MODELS TO PREDICT DEVELOPMENTAL AND REPRODUCTIVE TOXICITY OF CHEMICALS. H. Choudhury 1 , R. Venkatapathy 2 and C. Moudgal 1 . 1 NCEA, U.S. EPA, Sodertalje, Sweden and 2 ORISE/NCEA-U.S. EPA, Cincinnati, OH. Abstract 286 is located on page 70. Monday Afternoon, March 7 12:15 PM to 1:15 PM Ballroom B Monday Afternoon MEDICAL RESEARCH COUNCIL (MRC) LECTURE: NOVEL UNCOMPETITIVE ANTAGONISTS PROTECT NEURONS FROM EXCITOTOXIC, OXIDATIVE, AND NITROSATIVE STRESS Lecturer: Stuart A. Lipton, MD, PhD, Professor, Burnham/Salk/Scripps Research Institutes and UC San Diego. Monday Afternoon, March 7 12:15 PM to 1:15 PM Room RO1 ROUNDTABLE SESSION: ELECTROCARDIOGRAPHY SAFETY EVALUATION STUDIES–NEW TECHNIQUES AND APPROACHES Chairperson(s): Lewis B. Kinter, AstraZeneca Pharmaceuticals, Wilmington, DE and Dennis J. Murphy, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA. #339 12:15 ELECTROCARDIOGRAPHY SAFETY EVALUATION STUDIES: NEW TECHNIQUES AND APPROACHES. L. B. Kinter 1 and D. J. Murphy 2 . 1 Safety Assessment, AstraZeneca, Wilmington, DE and 2 Drug Safety Assessment, GlaxoSmithKline, King of Prussia, PA. #340 12:20 CARDIAC ELECTROPHYSIOLOGY FROM THE SINGLE CELL TO THE INTACT HEART. R. Hamlin. Veterinary Cardiology, Ohio State University, Columbus, OH. Sponsor: L. Kinter. #341 12:30 TECHNIQUES AND ELECTROGRAPHIC LEAD PLACEMENTS FOR IMPLANTED ECG MONITORS. R. Coatney. Animal Modeling & Imaging, GlaxoSmithKline, King of Prussia, PA. Sponsor: L. Kinter. MONDAY up-to-date information at www.toxicology.org 69
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Annual Meeting Events Calendar (Con
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Program - Society of Toxicology

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