Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1513 EVALUATION OF K6ODC TRANSGENIC MICE AS A DERMAL CARCINOGENICITY MODEL FOR ONCOGENIC DNA. T. J. Miller 1 , P. Espandiari 1 , R. Honchel 1 , A. D. Knapton 1 , J. Zhang 1 , F. Sistare 1 , L. Sheng 2 , A. M. Lewis 2 , K. Peden 2 and J. P. Hanig 1 . 1 CDER, U.S. FDA, Silver Spring, MD and 2 CBER, U.S. FDA, Rockville, MD. #1514 DETERMINATION OF THE SKIN CANCER POTENTIAL OF PETROLEUM-DERIVED MATERIALS USING K6/ODC MICE. M. A. Amoruso 1 , G. W. Trimmer 1 , R. C. Forgash 1 , S. Gilmour 2 and J. J. Freeman 1 . 1 Toxicology & Environmental Sciences, ExxonMobil Biomedical Sciences, Inc., Annandale, NJ and 2 Lankenau Institute for Medical Research, Wynnewood, PA. #1515 COMPARATIVE 30-WEEK DERMAL TUMOR PROMOTION STUDY USING SENCAR MICE: EVALUATION OF CIGARETTE SMOKE CONDENSATE FROM A CONTROL CIGARETTE AND TEST CIGARETTES WITH TWO BANDED CIGARETTE PAPER TECHNOLOGIES. D. R. Meckley 1 , D. H. Pence 1 , K. R. Van Kampen 2 , P. H. Ayres 1 and J. E. Swauger 1 . 1 R.J. Reynolds Tobacco Company, Winston-Salem, NC and 2 The Van Kampen Group, Hoover, AL. #1516 COMPARATIVE 13-WEEK INHALATION STUDY OF MAINSTREAM CIGARETTE SMOKE FROM CIGARETTES CONTAINING CAST SHEET TOBACCO. R. Potts, D. R. Meckley, K. Shreve, P. H. Ayres, D. H. Pence, C. D. Garner, D. J. Doolittle and J. E. Swauger. Scientific & Regulatory Affairs, R. J. Reynolds Tobacco Company, Winston-Salem, NC. #1517 DIFFERENTIATING INITIATING FROM PROMOTING EFFECTS OF CIGARETTE MAINSTREAM SMOKE IN THE PRODUCTION OF LUNG TUMORS IN A MOUSE INHALATION BIOASSAY. S. F. Yee, M. Misra, J. Hamm, R. Leverette, S. Vulimiri, D. Heck and N. Rajendran. Lorillard Tobacco Company, Greensboro, NC. #1518 CIGARETTE MAINSTREAM SMOKE AND GAS PHASE-DEPLETED PARTICULATE PHASE ENHANCE LUNG TUMORIGENICITY IN A/J MOUSE. W. Stinn 1 , H. Haussmann 1 , A. Buettner 1 and J. H. Arts 2 . 1 Philip Morris Research Laboratories GmbH, Cologne, Germany and 2 TNO Nutrition and Food Research, Zeist, Netherlands. #1519 INTERSPECIES SITE CONCORDANCE FOR MAMMARY CARCINOGENESIS BY ENVIRONMENTAL TOBACCO SMOKE. A. G. Salmon, M. D. Miller and M. A. Marty. OEHHA, California EPA, Oakland, CA. #1520 DEVELOPMENT OF QUANTITATIVE QSAR MODELS TO PREDICT CANCER POTENCY OF CHEMICALS. R. Venkatapathy 1 , C. Moudgal 2 and R. Bruce 2 . 1 ORISE/NCEA-U.S. EPA, Cincinnati, OH and 2 NCEA, U.S. EPA, Cincinnati, OH. #1521 CANCER RISK ESTIMATION FOR EXPOSURE TO NAPHTHALENE. S. Hoover, J. P. Brown, A. G. Salmon, M. S. Sandy, L. Zeise and M. A. Marty. OEHHA, California EPA, Oakland, CA. Wednesday Morning, March 9 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: NERVOUS SYSTEM: MECHANISMS OF TOXICITY Chairperson(s): Nasser H. Zawia, University of Rhode Island, Kingston, RI. Displayed: 9:30 AM–12:30 PM Attended: 9:30 AM–11:00 AM #1522 PROTECTIVE EFFECT OF NRF2 ON THE MUSCLE OF MICE WITH AMYOTROPHIC LATERAL SCLEROSIS. J. C. Kern 1,2 , A. D. Kraft 1 , A. Vermeern 1 and J. A. Johnson 1,2 . 1 Pharmaceutical Sciences, University of Wisconsin-Madison, Madison, WI and 2 Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI. #1523 SENSITIVITY TO MITOCHONDRIAL COMPLEX II INHIBITORS, MALONATE AND 3- NITROPROPIONIC ACID IN NRF2 KNOCKOUT MICE. M. Calkins 1,2 , R. J. Jakel 1,3,4 and J. A. Johnson 1,2,5 . 1 School of Pharmacy, University of Wisconsin, Madison, WI, 2 Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, 3 Neuroscience Training Program, University of Wisconsin, Madison, WI, 4 Medical Scientist Training Program, University of Wisconsin, Madison, WI and 5 Waisman Center, University of Wisconsin, Madison, WI. #1524 NEUROPROTECTIVE EFFECTS OF METALLOTHIONEIN-III IN MUTANT EXPANDED POLYGLUTAMINE EXPRESSED NEUROBLASTOMA CELLS. K. Lee 1 , Y. Hwang 1,2 , K. Jung 1,2 , D. Shin 1,2 , K. Oh 1,2 , J. Choi 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea. #1525 METALLOTHIONEIN III ATTENUATES 6- HYDROXYDOPAMINE-INDUCED APOPTOTIC CELL DEATH IN SH-SY5Y CELLS. Y. Hwang 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea. #1526 MITOCHONDRIAL-DEPENDENT INITIATION OF APOPTOSIS AND FEEDBACK REGULATION BY PKCδ IN PROTEOSOME INHIBITOR MG- 132-INDUCED DOPAMINERGIC DEGENERATION. F. Sun, A. Kanthasamy, Y. Yang, V. Anantharam and A. G. Kanthasamy. Biomedical Sciences, Iowa State University, Ames, IA. #1527 PROTEOSOME INHIBITOR ACLARUBICIN INDUCES DOPAMINERGIC CELL DEATH AND PARKINSON’S-LIKE SYMPTOMS IN MICE: IMPLICATIONS FOR UBIQUITIN- PROTEOSOME DYSFUNCTION IN PARKINSON’S DISEASE. C. Latchoumycandane, A. Vellareddy, A. Kanthasamy and A. Kanthasamy. Department of Biomedical Sciences, Iowa State University, Ames, IA. 166 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1528 THROMBIN PRECONDITIONING PREVENTS STRIATAL ATROPHY AND DOPAMINERGIC TERMINAL LOSS, BUT NOT DOPAMINE DEPLETION IN A 6−HYDROXYDOPAMINE PARKINSON′S DISEASE MODEL. J. R. Cannon 1,2 , Y. Hua 1 , G. Xi 1 and R. F. Keep 1,3 . 1 Department of Neurosurgery, The University of Michigan, Ann Arbor, MI, 2 Department of Envrionmental health Sciences, The University of Michigan, Ann Arbor, MI and 3 Department of Physiology, The University of Michigan, Ann Arbor, MI. #1529 ROLE FOR PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) IN MPTP-INDUCED DOPAMINERGIC NEUROTOXICITY. C. Hamill 1 , M. Caudle 2 , J. R. Richardson 2 , G. W. Miller 2 and S. F. Traynelis 1 . 1 Department of Pharmacology, Emory University, Atlanta, GA and 2 Center for Neurodegenerative Disease, Emory University, Atlanta, GA. #1530 NICOTINE STIMULATION INDUCES TH MESSENGER RNA EXPRESSION AND TRANSCRIPTION RATE IN MN9D CELLS. P. M. Radcliffe 1 and A. Tank 2 . 1 Toxicology, University of Rochester, Rochester, NY and 2 Pharmacology/Physiology, Univer of Rochester, Rochester, NY. #1531 NEUROPROTECTION AND NEURORESCUE AGAINST BETA-AMYLOID TOXICITY BY METALLOTHIONEIN III. C. Choi 3 , Y. Hwang 1,2 , D. Oh 1,2 , D. Shin 1,2 , J. Choi 1,2 , D. Kim 4 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea, 2 Research Center for Proteineous Materials, Chosun University, Kwangju, South Korea, 3 Division of Food Science, Chinju International University, Chinju, South Korea and 4 Pathology, College of Oriental Medicine, Daejeon University, Daejeon, South Korea. #1532 CHARACTERIZATION OF CEREBRAL SP1, Aβ AND APP IN RATS: AN IMMUNOHISTOCHEMICAL STUDY OF AGING AND NEURODEGENERATION. B. Brock, K. DiPalma, M. Basha and N. H. Zawia. Biomediacl and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI. #1533 THE CHOROID PLEXUS EXPRESSES THE ENZYMES NECESSARY FOR BETA-AMYLOID PRODUCTION. E. L. Smith, J. S. Crossgrove and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #1534 THE CHOROID PLEXUS ACCUMULATES BETA- AMYLOID FROM BRAIN CSF: IMPLICATIONS FOR ALZHEIMER’S DISEASE. J. S. Crossgrove, G. Li and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #1535 DIFFERENTIAL EXPRESSION OF GRP78 AND HSP70 IN PRIMARY BRAINSTEM AND CORTICAL ASTROCYTES EXPOSED TO 1, 3- DINTROBENZENE. S. A. Runkle, S. R. Steiner and M. A. Philbert. Toxicology Program, University of Michigan, Ann Arbor, MI. #1536 MIXED INHIBITION OF THE PYRUVATE DEHYDROGENASE COMPLEX BY M- DINITROBENZENE. J. A. Miller and M. A. Philbert. Toxicology Program, University of Michigan, Ann Arbor, MI. #1537 NITRIC OXIDE MEDIATES MITOCHONDRIAL DYSFUNCTION IN NEUROENDOCRINE TOXICITY. D. E. Heck 1,2 , J. Gray 1 , D. Osbourn 2 and P. J. Smith 2 . 1 Rutgers University, Piscataway, NJ and 2 Marine Biological Laboratory, Woods Hole, MA. #1538 NITRIC OXIDE ACTIVATES P53 AND INDUCES APOPTOSIS IN NEURONAL PC12 CELLS. C. Brynczka 1,2 and A. Merrick 1 . 1 National Center For Toxicogenomics, NIEHS, Research Triangle Park, NC and 2 Environmental and Molecular Toxicology, NCSU, Raleigh, NC. #1539 EVALUATION OF THE INTERACTION BETWEEN CAVEOLIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN C6 GLIA. G. Velazquez 1 , E. E. Aquino 1 , N. Mayol 2 , H. Maldonado 2 and W. I. Silva 1 . 1 Physiology, UPR Medical Sciences Campus, San Juan, Puerto Rico and 2 Pharmacology, Caribbean Central University, Bayamon, Puerto Rico. Sponsor: B. Jimenez Velez. #1540 REACTIVE GLIOSIS IN NEUROTOXIC AND MECHANICAL INJURY MODELS. C. L. Damiani, D. B. Miller and J. P. O’Callaghan. CDC-NIOSH, Morgantown, WV. #1541 ERK1/2-RSK2 STIMULATION OF MEF2C TRANSCRIPTION PROMOTES CORTICAL NEURON SURVIVAL. Y. Wang, L. Liu and Z. Xia. Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. #1542 DEVELOPMENTAL LEAD EXPOSURE AFFECTS THE SURVIVAL OF GRANULE CELLS IN THE RAT HIPPOCAMPUS. T. Verina, C. A. Rohde and T. R. Guilarte. Environmental Health Sciences, Johns Hopkins University, Baltimore, MD. #1543 PPAR ALPHA ACTIVATION ENHANCES CYANIDE-INDUCED NEUROTOXICITY BY UP- REGULATION OF UCP-2. X. Zhang, L. Li, K. Prabhakaran, J. L. Borowitz and G. E. Isom. Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN. #1544 NEUROPROTECTION AGAINST METHAMPHETAMINE (METH) AFFORDED BY PRETREATMENT WITH INCREASING DOSES OF THE DRUG IS DEPENDENT ON THE DOSING SCHEDULE OF METH USED DURING THE DRUG CHALLENGE. D. L. Graham 1,2 , P. H. Noailles 1 , B. Ladenheim 1 , T. H. Moran 3 and J. L. Cadet 1 . 1 Molecular Neuropsychiatry Branch, DHHS/NIH/NIDA/IRP, Baltimore, MD, 2 Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD and 3 Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD. WEDNESDAY up-to-date information at www.toxicology.org 167
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Author Index (Continued) 44 th Annu
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