Program - Society of Toxicology
Program - Society of Toxicology
Program - Society of Toxicology
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44 th Annual Meeting<br />
and ToxExpo<br />
<strong>Program</strong> Description<br />
MONDAY<br />
#459 THE INCREASE IN TOTAL IGE IN SERUM OF<br />
FEMALE MICE AFTER INTRANASAL<br />
EXPOSURE OF CARBON BLACK PARTICLES<br />
WITH POLLEN. K. Kobayashi 1 , K. Itoh 1 , Y. Inoue 1 ,<br />
Y. Kudo 1 , M. Tsunoda 1 , T. Satoh 1 , C. Yashiro 2 , Y.<br />
Sugita-Konishi 2 and Y. Aizawa 1 . 1 Preventive Medicine<br />
and Public Health, Kitasato University School <strong>of</strong><br />
Medicine, Sagamihara, Kanagawa, Japan and 2 Division<br />
<strong>of</strong> Microbiology, National Institute <strong>of</strong> Health Sciences,<br />
Setagaya-ku, Tokyo, Japan.<br />
#460 DIESEL AND HARDWOOD SMOKE EMISSIONS<br />
DIFFERENTIALLY AFFECT CLEARANCE AND<br />
INFLAMMATION OF INTRATRACHEALLY<br />
INSTILLED PSEUDOMONAS AERUGINOSA. M.<br />
Reed 1 and K. S. Harrod 2 . 1 <strong>Toxicology</strong>, Lovelace<br />
Respiratory Research Institute, Albuquerque, NM and<br />
2 Infectious Disease <strong>Program</strong>, Lovelace Respiratory<br />
Research Institute, Albuquerque, NM.<br />
Monday Afternoon, March 7<br />
1:30 PM to 4:30 PM<br />
Exhibit Hall<br />
#465 PHARMACOLOGY AND TOLERABILITY OF<br />
INS50589, A REVERSIBLE P2Y 12 RECEPTOR<br />
ANTAGONIST WITH ANTI-PLATELET<br />
AGGREGATION ACTIVITY, ADMINISTERED BY<br />
CONTINUOUS INTRAVENOUS INFUSION IN<br />
RATS AND DOGS. M. S. Cowlen, C. S. Crean, R.<br />
Krishnamoorthy, P. S. Watson, J. L. Boyer, W. M.<br />
Peterson and S. A. Anderson. Inspire, Durham, NC.<br />
#466 RANGE-FINDING TOXICITY STUDIES WITH<br />
SQ109, AN ANTI-TUBERCULAR AGENT, IN<br />
RATS AND DOGS. E. Glaze 1 , Y. Chen 2 , L. Alex 2 , R.<br />
Morrissey 3 , L. Jia 1 , P. Noker 4 and J. Tomaszewski 1 .<br />
1 2 NIH, Rockville, MD, University <strong>of</strong> Illinois, Chicago,<br />
IL, 3 Pathology Associates, Chicago, IL and 4 Southern<br />
Research Institute, Birmingham, AL.<br />
#467 SAFETY ASSESSMENT OF A NOVEL P38<br />
INHIBITOR IN CYNOMOLGUS MONKEYS<br />
FOLLOWING DAILY ORAL DOSING. S. L. Wild 1 ,<br />
T. Pabst Marra 1 , G. Jang 1 , W. Min 1 , R. House 3 , A.<br />
Mould 2 and M. Cosenza 1 . 1 Amgen Inc., Thousand Oaks,<br />
CA, 2 Covance Laboratories Inc., Madison, WI and<br />
3 DynPort Vaccine Company LLC, Frederick, MD.<br />
POSTER SESSION: PHARMACEUTICALS-GENERAL<br />
Chairperson(s): Mary Moslem, University <strong>of</strong> Texas, Galveston, TX.<br />
Displayed: 1:30 PM–4:30 PM<br />
Attended: 3:00 PM–4:30 PM<br />
#461 SAFETY EVALUATION OF AEROSOLIZED<br />
CYCLOSPORINE IN RATS AND DOGS. T. Wang 1 ,<br />
R. Steigerwalt 1 , M. Lynch 2 , R. Kovelesky 1 , C.<br />
Rodriguez 1 and K. Sprugel 1 . 1 Drug Assessment and<br />
Development, Chiron Corporation, Emeryville, CA and<br />
2 <strong>Toxicology</strong>, Battelle, Columbus, OH.<br />
#462 TOXICITY OF A SELECTIVE INHIBITOR OF<br />
LCK IS DUE TO INHIBITION OF LCK AND IS<br />
NOT CHEMOTYPE-RELATED. R. F. Stachlewitz 1 ,<br />
A. J. Schwartz 1 , B. Bettencourt 1 , J. Syed 1 , D. Conlon 1 ,<br />
J. E. Erickson 1 , E. O’Connor 1 , D. J. Calderwood 2 and<br />
G. C. Hirst 2 . 1 Discovery Safety, Metabolism &<br />
Pharmacokinetics, Abbott Bioresearch Center, Abbott<br />
Laboratories, Worcester, MA and 2 Chemistry, Abbott<br />
Bioresearch Center, Abbott Laboratories, Worcester,<br />
MA.<br />
#463 THE IMMUNOHISTOCHEMICAL EXPRESSION<br />
OF UROPLAKIN III IN RAT BLADDER TISSUE.<br />
S. Grainger. Covance Laboratories Ltd., Harrogate,<br />
United Kingdom. Sponsor: D. Everett.<br />
#464 BORTEZOMIB (VELCADE®) DOES NOT<br />
INDUCE THE FORMATION OF PROTEINASE K-<br />
RESISTANT PRION PROTEIN IN MURINE AND<br />
HUMAN NEURONAL CELL LINES IN VITRO. V.<br />
G. Sasseville 1 , A. Raczynski 1 , V. Csizmadia 1 , W.<br />
Riordan 1 , J. Ironside 2 , M. Rolfe 1 and P. Bouchard 1 .<br />
1 Millennium Pharmaceuticals, Inc., Cambridge, MA and<br />
2 University <strong>of</strong> Edinburgh, Edinburgh, United Kingdom.<br />
Sponsor: C. Alden.<br />
#468 CYTOFLAVINE REDUCES HYPOXIA CAUSED<br />
BY SEVERE ALCOHOLIC INTOXICATION AND<br />
MILD HEAD TRAUMA. A. D. Tsivinsky 1,3 , B. V.<br />
Batotsyrenov 2 , T. N. Savateeva 1 , V. E. Marusanov 3 and<br />
A. L. Kovalenko 1 . 1 Institute <strong>of</strong> <strong>Toxicology</strong>,<br />
St.Petersburg, Russian Federation, 2 Regional Poison<br />
Center, St.Petersburg, Russian Federation and<br />
3 Postgraduate Medical Academy, St.Petersburg, Russian<br />
Federation. Sponsor: J. Waksman.<br />
#469 TEMPO ATTENUATION OF DICLOFENAC<br />
ADDUCTION AND ENTEROPATHY. L. Kaphalia 1 ,<br />
J. F. Aronson 1 , K. A. Nethery 1 and M. Treinen<br />
Moslen 1,2 . 1 Pathology, University <strong>of</strong> Texas Medical<br />
Branch, Galveston, TX and 2 Internal Medicine,<br />
University <strong>of</strong> Texas Medical Branch, Galveston, TX.<br />
#470 ENDOSCOPY STUDY OF THE<br />
GASTROINTESTINAL TOLERANCE OF<br />
STRONTIUM RANELATE IN CYNOMOLGUS<br />
MONKEYS. C. Fisch 1 , M. Attia 1 , F. Dargent 1 , S. de<br />
Jouffrey 1 , I. Dupin-Roger 2 and J. Claude 3 . 1 CIT,<br />
Evreux, France, 2 Laboratoires Servier, Courbevoie,<br />
France and 3 Paris V University, Paris, France.<br />
#471 TC 1734-112: PRECLINICAL SAFETY<br />
ASSESSMENT OF A SELECTIVE α4β2<br />
NICOTINIC ACETYLCHOLINE RECEPTOR<br />
AGONIST. V. M. Traina, G. J. Gatto and M. Bencherif.<br />
<strong>Toxicology</strong>, Targacept, Inc., Winston-Salem, NC.<br />
#472 OPIOIDS: OCCUPATIONAL CONTACT<br />
DERMATITIS AND THE LOCAL LYMPH NODE<br />
ASSAY (LLNA). M. J. Olson 1 , F. J. Guerriero 2 , M.<br />
Cunningham-Hill 2 and N. Tapscott 2 . 1 GlaxoSmithKline,<br />
Research Triangle Park, NC and 2 GlaxoSmithKline,<br />
Philadelphia, PA.<br />
82<br />
SOT’s 44 th Annual Meeting
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