Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY #1214 EFFECTS OF DIESEL EXHAUST ON PULMONARY RESPONSES DURING ALLERGIC SENSITIZATION TO AEROSOLIZED OVALBUMIN IN BALB/C MICE. P. Singh 1 , M. J. Daniels 1 , D. L. Andrews 1 , E. H. Boykin 1 , T. Krantz 1 , W. P. Linak 2 and I. Gilmour 1 . 1 NHEERL, U.S. EPA, Research Triangle Park, NC and 2 NRMRL, U.S. EPA, Research Triangle Park, NC. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: SIGNAL TRANSDUCTION I Chairperson(s): Russell Thomas, CIIT, Research Triangle Park, NC. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1215 GLABRIDIN INHIBITS INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY BLOCKING NUCLEAR FACTOR-κB ACTIVATION IN MURINE MACROPHAGES. J. Kang, Y. Yoon, I. Cho, M. Han, C. Lee, S. Park and H. Kim. Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Taejon, South Korea. #1216 RHOA/ROCK SIGNALING NEGATIVELY REGULATES NUCLEAR FACTOR KAPPA B (NFκB) ACTIVATION VIA MODULATION OF IκBα LEVELS IN KIDNEY EPITHELIAL CELLS. M. E. Ellis, W. W. Polk, J. V. Kushleika, P. L. Simmonds and J. S. Woods. Environmental Health, University of Washington, Seattle, WA. #1217 INDUCTION OF NUCLEAR FACTOR-KB ACTIVATION THROUGH TAK1 AND NIK BY DIESEL EXHAUST PARTICLES IN L2 CELL LINES. J. Lee 2 , K. Lee 2 , Y. Lim 1 , H. Kim 3 and H. Sohn 4 . 1 Occ. & Env. Med., St. Mary’s Hospital, Seoul, South Korea, 2 Pharmacology, The Catholic. University of Korea, Seoul, South Korea, 3 Internal Med., Youngdong Severance Hospital, Seoul, South Korea and 4 Preventive Med., Inje University, Busan, South Korea. Sponsor: I. Yu. #1218 APPLICATION OF A HIGH-COVERAGE, FUNCTIONAL GENOMIC SCREEN TO DISSECT THE NFκB SIGNALING PATHWAY. T. A. Halsey, T. J. Page, L. Pluta and R. S. Thomas. CIIT Centers for Health Research, Research Triangle Park, NC. #1219 TRPV1 ANTAGONISTS INDUCE TRANSLOCATION OF INTRACELLULAR TRPV1 TO THE PLASMA MEMBRANE ENHANCING VANILLOID-INDUCED TOXICITIES. M. E. Johansen 1 , C. A. Reilly 1 , D. L. Lanza 1 , J. Lee 2 and G. S. Yost 1 . 1 Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT and 2 College of Pharmacy, Seoul National University, Shinlim-Dong, South Korea. #1220 INDUCTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 2 EXPRESSION BY CYCLIC AMP-DEPENDENT SIGNALING PATHWAY IN MOUSE HEPA-1 CELLS. C. Chen, X. G. Cheng and C. D. Klaassen. University of Kansas Medical Center, Kansas City, KS. #1221 TOBACCO SMOKE-INDUCED EPITHELIAL CELL PROLIFERATION AND SQUAMOUS METAPLASIA IN THE LUNGS OF RATS: ROLE OF MAPK/AP-1 PATHWAY. C. Zhong, Y. Zhou and K. E. Pinkerton. CHE, University of California, Davis, CA. #1222 MAPPING GENE EXPRESSION NETWORKS: USING WHOLE GENOME EXPRESSION ANALYSIS WITH RNAI TO DEFINE THE HEAT SHOCK SIGNAL TRANSDUCTION CASCADE. T. Page, T. Halsey, L. Pluta and R. S. Thomas. CIIT, Research Triangle Park, NC. #1223 IDENTIFICATION OF SIGNALING PATHWAYS ACTIVATING REACTIVE GLIOSIS IN MULTIPLE MODELS OF BRAIN INJURY: A GENOMIC, PROTEOMIC AND PROTEIN PHOSPHORYLATION ANALYSIS. K. Sriram and J. P. O’Callaghan. Centers for Disease Control & Prevention (CDC)-NIOSH, Morgantown, WV. #1224 CHANGES IN EXPRESSION OF TOTAL AND PHOSPHORYLATED ERK1/2 IN TCDD- EXPOSED EMBRYONIC MOUSE PALATES. C. J. Wolf and B. Abbott. Reproductive Toxicology Division, U.S. EPA, ORD, NHEERL, Research Triangle Park, NC. #1225 INTERACTIONS WITH THE TGF-β SIGNALING PATHWAY: A KEY MECHANISM OF DEVELOPMENTAL TOXICITY? T. W. Thomas 1,2 and C. A. Kimmel 2 . 1 AAAS Risk Policy Fellow, Washington, DC and 2 NCEA, U.S. EPA, Washington, DC. #1226 DIABETES-INDUCED NEPHROPATHY ASSOCIATES WITH AKT AND P38 KINASE ACTIVATION. Y. Song, R. Wu, M. Barati, M. Rane and L. Cai. Medicine, University of Louisville, Louisville, KY. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: DISPOSITION/PHARMACOKINETICS Chairperson(s): James Bruckner, University of Georgia, Athens, GA. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1227 DISPOSITION OF TCDD IN A MOUSE MODEL OF OBESITY AND TYPE II DIABETES. J. J. Diliberto, M. J. DeVito, D. G. Ross, V. M. Richardson and L. S. Birnbaum. NHEERL, U.S. EPA, Research Triangle Park, NC. 142 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1228 MATERNAL AND FETAL DISPOSITION OF GENISTEIN GLUCURONIDE AND SULFATE CONJUGATES FOLLOWING 14-DAY IN UTERO EXPOSURE TO GENISTEIN. N. V. Soucy, H. D. Parkinson, M. A. Sochaski and S. J. Borghoff. CIIT Centers for Health Research, Research Triangle Park, NC. #1229 THE CANALICULAR TRANSPORTER MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2 FACILITATES BILIARY EXCRETION OF DIETHYLSTILBESTROL. M. Z. Dieter, T. L. Callaghan and C. D. Klaassen. University of Kansas Medical Center, Kansas City, KS. #1230 DISPOSITION OF 2, 2′, 4, 4′, 5, 5′- HEXABROMODIPHENYL ETHER IN F344 RATS AND B6C3F1 MICE. E. H. Lebetkin 1 , J. M. Sanders 1,2 , A. C. Creech 1,3 and L. T. Burka 1 . 1 LPC, NIEHS, Research Triangle Park, NC, 2 Department of Toxicology, NCSU, Raleigh, NC and 3 NCSU, Raleigh, NC. #1231 METABOLISM AND TISSUE DOSIMETRY OF PENTAVALENT AND TRIVALENT MONOMETHYLATED ARSENIC AFTER ORAL ADMINISTRATION IN MICE. M. F. Hughes 1 , V. Devesa 2 , B. M. Adair 1 , M. Styblo 2 , E. M. Kenyon 1 and D. J. Thomas 1 . 1 ORD/NHEERL, U.S. EPA, Research Triangle Park, NC and 2 CEMALB, University of North Carolina, Chapel Hill, NC. #1232 PHARMACOKINETIC EVALUATION OF PERFLUOROOCTANOIC ACID IN THE MOUSE. C. Lau 1 , M. J. Strynar 2 , A. B. Lindstrom 2 , R. G. Hanson 1 , J. R. Thibodeaux 1 and H. A. Barton 3 . 1 Reproductive Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC, 2 Human Exposure and Atmospheric Sciences Division, NERL, ORD, U.S. EPA, Research Triangle Park, NC and 3 Experimental Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #1233 INITIAL SKIN PENETRATION STUDY FOR DETERMINING BIS-(2- CHLOROETHOXY)METHANE (CEM) TOXICOKINETICS AFTER A SINGLE DERMAL APPLICATION IN RODENTS. S. HONG 1 , J. D. Johnson 1 , S. W. Graves 1 , B. Burback 1 , J. Merrill 1 and C. SMITH 2 . 1 Battelle Memorial Institute, Columbus, OH and 2 NIEHS, NIH, Research Triangle Park, NC. #1234 RODENT PLASMA AND TISSUE CONCENTRATION TIME COURSE DATA FOR BIS (2-CHLOROETHOXY)METHANE: A PRELIMINARY IV STUDY. J. W. Merrill 1 , J. D. Johnson 1 , S. Hong 1 , S. W. Graves 1 , B. Burback 1 and C. Smith 2 . 1 Battelle, Columbus, OH and 2 NIEHS, NIH, Research Triangle Park, NC. #1235 EFFECTS OF PARTICLE SIZE ON THE SYSTEMIC BIOAVILABILITY IN RATS FOLLOWING INHALATION EXPOSURE. S. Hu 1 , B. Naumann 2 , M. Cwik 1 and N. Rajendran 1 . 1 IIT Research Institute, Chicago, IL and 2 Merck & Co., Inc., Whitehouse Station, NJ. #1236 EVALUATION OF THE HALF-LIFE (T 1/2 ) OF ELIMINATION OF PERFLUOROOCTANOATE (PFOA) FROM HUMAN SERUM. D. Ehresman 1 , G. Olsen 1 , J. Burris 1 , J. Froehlich 2 , A. Seacat 1 and J. Butenhoff 1 . 1 Medical Department, 3M Company, St. Paul, MN and 2 Pace Analytical, St. Paul, MN. #1237 DISPOSITION OF [ 14 C] DECAMETHYLCYCLOPENTASILOXANE ([ 14 C]D 5 ) IN FISCHER 344 RATS FOLLOWING SINGLE AND MULTIPLE INHALATION EXPOSURE. J. M. Tobin, D. A. McNett, J. A. Durham and K. P. Plotzke. Health and Environmental Sciences, Dow Corning Corporation, Auburn, MI. #1238 TOXICOKINETICS OF 14C-RDX IN MINIATURE PIGS. G. Reddy 1 , M. A. Major 1 , M. A. Berge 2 and S. Patzer 2 . 1 Directorate Toxicology, U.S.Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD and 2 Covance Laboratories Inc., Madison, WI. #1239 TOXICOKINETICS OF TETRABROMOBISPHENOL A IN HUMAN SUBJECTS. W. Dekant, W. Voelkel and U. Schauer. Department of toxicology, University of Wuerzburg, Wuerzburg, Germany. #1240 TISSUE DISTRIBUTION OF 14 C- ACETAMINOPHEN IN THE MONKEY USING QUANTITATIVE AUTORADIOLUMINOGRAPHY OR LIQUID SCINTILLATION COUNTING. O. Boutherin-Falson 1 , L. Faure 1 , A. Raynard 1 , M. Maynaud 1 and J. Descotes 2 . 1 MDS Pharmacology Services, St Germain s/ L’Arbresle, France and 2 Poison Center, Lyon, France. #1241 ETHYLENE GLYCOL UPTAKE IN VOLUNTEERS EXPOSED BY INHALATION AND BY THE DERMAL ROUTE. S. Upadhyay, J. Carstens, T. H. Faller, H. Greim, G. A. Csanady and J. G. Filser. Toxicology, GSF, Neuherberg, Germany. #1242 STRATEGIES TO ASSESS SYSTEMIC EXPOSURE OF TEST MATERIAL IN SUBCHRONIC STUDIES. S. A. Saghir, A. L. Mendrala, M. J. Bartels, S. J. Day, S. C. Hansen, J. M. Sushynski and J. S. Bus. Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI. #1243 THE EFFECT OF DOSE ON THE METABOLIC PROFILE OF TRICHLOROETHYLENE. C. Hines 2 , S. Muralidhara 2 , C. A. White 2 and J. V. Bruckner 2 . 1 2 University Of Georgia, Athens, GA, Pharmaceutical and Biomedical Sciences, UGA, Athens, GA, 3 UGA, Athens, GA and 4 UGA, Athens, GA. #1244 MATERNAL AND FETAL DISPOSITION OF LAMIVUDINE, ZIDOVUDINE, AND LAMIVUDINE-ZIDOVUDINE IN THE PREGNANT RAT. S. Lewis 1 , Y. Alnouti 2 , M. Bartlett 1 and C. White 1 . 1 Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA and 2 University of Kansas Medical Center, Kansas City, KS. Sponsor: J. Bruckner. TUESDAY up-to-date information at www.toxicology.org 143
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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