Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#503 ACTIVATION OF HUMAN AH RECEPTOR
SIGNALING BY POLYCYCLIC AROMATIC
HYDROCARBONS AND EXTRACTS OF SOILS
FROM THE NEW ORLEANS AREA. C. A. Miller 1 ,
G. Wang 2 , J. Hughes 3 and A. Alnafisi 1 . 1 Environmental
Health Sciences, Tulane University, New Orleans, LA,
2 Chemistry, Xavier University, New Orleans, LA and
3 Biostatistics, Tulane University, New Orleans, LA.
#504 INDUCTION OF CYCLOOXYGENASE-2 IN THE
LUNGS OF RATS EXPOSED TO TOBACCO
SMOKE. K. R. Smith 1 , S. T. Owens 1 , A. W. Goodyear 1 ,
U. P. Kodavanti 2 and K. E. Pinkerton 1 . 1 Center for
Health and the Environment, University of California,
Davis, CA and 2 NHEERL, U.S. EPA, Research Triangle
Park, NC.
#505 DNA AND HEMOGLOBIN ADDUCTS FROM
ORAL ADMINISTRATION OF ACRYLAMIDE TO
MALE FISCHER 344 RATS. T. Fennell 1 , R. W.
Snyder 1 and M. A. Friedman 2 . 1 RTI International,
Research Triangle Park, NC and 2 UMDNJ, Newark, NJ.
#506 CHARACTERIZATION OF MAINSTREAM
CIGARETTE SMOKE-INDUCED CHRONIC
INFLAMMATION IN ICR AND C57BL/6 MICE. K.
C. Hodge-Bell 1 , K. M. Lee 2 , A. F. Fuciarelli 2 , R. A.
Renne 2 , S. J. Harbo 2 and W. J. McKinney 1 . 1 Research &
Technology, Phillip Morris USA, Richmond, VA and
2 Battelle Toxicology Northwest, Richland, WA.
#507 NANBIOTECHNOLOGY: AUTOMATED REAL-
TIME MEASURES OF TOXICANT INFLUENCE
ON CELL SPEED IN CHEMOTACTIC
ENVIRONMENTS. X. Yin, N. Hadjout, D. Knecht and
M. A. Lynes. Molecular and Cell Biology, University of
Connecticut, Storrs, CT, CT.
#508 MODULATION OF EXTRACELLULAR MATRIX
MARKS EARLY DEGENERATION OF KIDNEY
PAPILLAE INTERSTITIAL CELLS (IC) OF RATS
DOSED WITH INDOMETHACIN (IND). P.
Ciaccio 1 , S. Emeigh Hart 1 , J. Bartock 1 , V. Oreffo 2 , C.
Kind 2 , K. Kenne 3 , S. Matis 1 , F. Pognan 4 and B.
Graham 4 . 1 Safety Assessment, Astrazeneca
Pharmacology, Wilmington, DE, 2 Astrazeneca
Pharmacology, Leicestershire, United Kingdom,
3 Astrazeneca Pharmacology, Sodertalje, Sweden and
4 Astrazeneca Pharmacology, Macclesfield, United
Kingdom.
#509 A METABONOMICS INVESTIGATION OF THE
HEPTOTOXICITY OF VALPROIC ACID. L. K.
Schnackenberg 1 , D. Hansen 2 and R. D. Beger 1 .
1 Division of Systems Toxicology, National Center for
Toxicological Research, Jefferson, AR and 2 Division of
Genetic and Reproductive Toxicology, National Center
for Toxicological Research, Jefferson, AR.
#510 POTENTIAL ROLE OF METHYLGUANIDINE
FOUND IN METABONOMICS INVESTIGATION
OF NEPHROTOXICITY. A. Amberg 1 , I.
Stammberger 1 , M. Kurz 2 , M. Will 2 , H. Juretschke 3 and
M. Gerl 3 . 1 Drug Safety Evaluation, Sanofi Aventis,
Hattersheim, Germany, 2 Chemistry, Sanofi Aventis,
Frankfurt, Germany and 3 Gobal Experimental Medicine,
Sanofi Aventis, Frankfurt, Germany. Sponsor: M.
Bonnefoi.
#511 PATTERN RECOGNITION OF NMR SPECTRA
OF URINE FROM WISTAR RATS DOSED WITH
LIVER AND RENAL TOXICANTS. R. D. Beger 1 , L.
K. Schnackenberg 1 , Y. P. Dragan 1 , M. D. Reily 2 and D.
G. Robertson 3 . 1 Division of Systems Toxicology,
National Center for Toxicological Research, Jefferson,
AR, 2 Discovery Technologies, Pfizer, Ann Arbor, MI
and 3 World Wide Safety Sciences, Pfizer, Ann Arbor,
MI.
#512 DIBUTYLTIN EXPOSURE ALTERS
CIRCULATING BLOOD GROWTH FACTOR
LEVELS. T. Lyons-Darden 1 , S. Jenkins 2 , R. Luebke 4
and S. Barone 3 . 1 Neurotoxicology, U.S. EPA, Research
Triangle Park, NC, 2 Office of Air Quality Planning and
Standards, U.S. EPA, Research Triangle Park, NC,
3 National Center for Environmental Assessment, U.S.
EPA, Washington, DC and 4 Environmantal Toxicology,
U.S. EPA, Research TRaingle Park, NC.
#513 EVALUATION OF CYTOCHROME P450 1A1 AND
1B1 IN HUMAN BLOOD LYMPHOCYTES AS
BIOMARKERS OF EXPOSURE TO DIOXIN-LIKE
COMPOUNDS. M. van Duursen, T. Sanderson and M.
van den Berg. Institute for Risk Assessment Sciences,
Utrecht, Netherlands.
#514 MULTI-TISSUE CHARACTERIZATION OF
RHABDOMYOLYSIS FOR THE HIGH PROFILE
FAILURE CERIVASTATIN. B. Ganter and K. L.
Kolaja. Chemogenomics and Toxicology, Iconix
Pharmaceuticals, Mountain View, CA.
#515 EVALUATION OF KIDNEY TOXICITY
DETECTION METHODS: URINARY GSTS AND
PROTEIN PROFILING BY SELDI-TOF-MS. K.
Okamoto 1,2 , W. W. Collette 2 , M. Mondal 2 , A. de
Peyster 1 and G. J. Stevens 2 . 1 Graduate School of Public
Health, San Diego State University, San Diego, CA and
2 Worldwide Safety Sciences, Pfizer Global Research
and Development, San Diego, CA.
#516 CHARACTERIZATION OF EPOXIDE ADDUCTS
OF POLYCYCLIC AROMATIC
HYDROCARBONS (PAH) WITH HEMOGLOBIN
(HB). M. Y. Ali, H. E. Hurst and S. R. Myers.
Pharmacology and Toxicology, Center for
Environmental and Occupational Health Sciences,
University of Louisville, Louisville, KY.
#517 EXHALATION OF CYTOKINES BY
LABORATORY RODENTS. E. Bermudez and O. R.
Moss. CIIT Centers for Health Research, Research
Triangle Park, NC.
#518 THE INFLUENCE OF DIET ON ENDPOINTS
TYPICALLY USED IN 13-WEEK TOXICITY
STUDIES FOR RODENTS. E. Harvey 2 , L. J. Betz 2
and G. Travlos 1 . 1 NIEHS, Durham, NC and 2 Constella
Health Sciences, Durham, NC. Sponsor: C. Portier.
MONDAY
up-to-date information at www.toxicology.org 85