Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY #1873 EXPOSURE TO TCDD AUGMENTS CD25 EXPRESSION ON RECENTLY ACTIVATED T CELLS. C. J. Funatake, L. B. Steppan and N. I. Kerkvliet. Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. #1874 ∆ 9 -TETRAHYDROCANNABINOL (∆ 9 -THC) ELICITS A CALCIUM ELEVATION IN T CELLS THROUGH THE TRPC CHANNELS. G. Rao 1,2 and N. E. Kaminski 1,2 . 1 Pharmacology and Toxicology, Michigan State University, East Lansing, MI and 2 Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1875 SODIUM ARSENITE DECREASES PROLIFERATION IN PHA-STIMULATED LYMPHOCYTES, BY INHIBITING INTERLEUKIN-2 EXPRESSION AND SECRETION. P. C. Conde-Moo, L. C. Acosta- Saavedra, M. E. Cebrian and E. S. Calderon-Aranda. Toxicologia, Cinvestav, Mexico, DF, Mexico. #1876 MECHANISMS OF 4-HYDROXYNONENAL-HNE (LIPID HYDROPEROXIDE) INDUCED APOPTOTIC DEATH IN CD4 T LYMPHOCYTES: RELEVANCE TO HIV AND HCV PATHOGENESIS. W. Chang 1 , R. Sahoo 2 , S. Srivastava 2 , C. J. McClain 2,1 , T. S. Chen 1 and S. S. Barve 2,1 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY and 2 Medicine, University of Louisville, Louisville, KY. #1877 MECHANISMS OF LEAD-INDUCED IMMUNOTOXICITY: THE ROLE OF IL-2 IN ALLO-ENHANCEMENT. S. M. Hueber, D. G. Farrer and M. J. McCabe. Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY. #1878 ENFUVIRTIDE: IN VITRO STUDIES OF PUTATIVE IMMUNOTOXIC EFFECTS RELATED TO ACTIVATION OF N-FORMYL PEPTIDE RECEPTORS. F. Regenass 1 , M. Adibzadeh 1 , T. D. Steele 2 and H. Kropshofer 1 . 1 Nonclinical Drug Safety, Hoffmann-LaRoche, Inc., Basel, Switzerland and 2 Nonclinical Drug Safety, Hoffmann-LaRoche, Inc., Nutley, NJ. Sponsor: A. Braen. #1879 INFLAMMATORY RESPONSES IN MOUSE RAW264.7 MACROPHAGES CAN BE ALTERED BY INTERACTIONS BETWEEN INDOOR AIR MICROBES IN SIMULTANEOUS EXPOSURE. P. Penttinen 1,2 , K. Huttunen 1 , J. Pelkonen 2,3 and M. Hirvonen 1 . 1 Department of Environmental Health, National Public Health institute, Kuopio, Finland, 2 3 University of Kuopio, Kuopio, Finland and Kuopio University Hospital, Kuopio, Finland. Sponsor: M. Viluksela. #1880 SIMULTANEOUS EXPOSURE TO MOLDY HOUSE MICROBES STREPTOMYCES CALIFORNICUS AND STACHYBOTRYS CHARTARUM CAUSE SYNERGISTIC INFLAMMATORY RESPONSES IN HUMAN WHOLE BLOOD CELL CULTURE. M. Roponen, K. Huttunen, M. Lappalainen and M. Hirvonen. Department of Environmental Health, National Public Health Institute, Kuopio, Finland. Sponsor: M. Viluksela. #1881 THE BIOLOGICAL ACTIVITY OF GRAM- POSITIVE BACTERIA STREPTOMYCES CALIFORNICUS CANNOT BE COMPLETELY INHIBITED WITH LPS -INHIBITOR PMX. K. Huttunen, A. Halinen and M. Hirvonen. Department of Environmental Health, National Public Health Institute, Kuopio, Finland. Sponsor: M. Viluksela. #1882 IN VITRO AND IN VIVO IMMUNOLOGIC RESPONSES BY POLYACRYLAMIDE NANOPARTICLES TO MH-S CELLS AND RATS. R. J. Schneider 1 , R. Reddy 2 and M. A. Philbert 1 . 1 Environmental Health Sciences, University of Michigan, Ann Arbor, MI and 2 Molecular Therapeutics, Inc., Ann Arbor, MI. #1883 IMPACT OF EXPOSURE TO JET A JET FUEL ON CYTOKINE PRODUCTION IN RAT LUNG MACROPHAGES. D. L. Courson 1 , E. R. Wilfong 1 , J. R. Cunningham 2 , E. W. Johnson 1 and S. Lohrke 1 . 1 Naval Health Research Center / Detachment EHE Laboratory, Wright-Patterson AFB, Fairborn, OH and 2 Wright State University, Fairborn, OH. #1884 MACROPHAGES ARE THE PROXIMAL TARGET CELL IN LEAD-INDUCED IMMUNOTOXICITY. D. G. Farrer and M. J. McCabe. Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY. #1885 WOOD DUST-INDUCED PULMONARY INFLAMMATION IN MICE. J. Maatta, M. Lehto, M. Leino, S. Tillander, H. Haataja, K. Savolainen and H. Alenius. Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland. #1886 ATRAZINE-INDUCED INHIBITION OF NK-CELL MEDIATED CYTOTOXICITY. A. M. Rowe 1 , K. M. Brundage 1,2 , R. Schafer 2 and J. B. Barnett 1,2 . 1 Microbioloy, Immunology and Cell Biology, West Virginia University, Morgantown, WV and 2 Mary Babb Randolph Cancer Center, Morgantown, WV. #1887 ALTERATIONS IN CYTOKINE PRODUCTION IN THE PRESENCE OF THE PESTICIDES, BENTAZON, ISOXAFLUTOLE AND TERBUFUS. K. M. Brundage 1 and R. S. Ellis 2 . 1 Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV and 2 BlueField State College, Bluefield, WV. 192 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1888 THE FUNGICIDES ETHYLENEBISDITHIOCARBAMATES INHIBIT NF-KB ACTIVATION AND CYTOKINE PRODUCTION IN THE HUMAN PROMYELOCYTIC CELL LINE THP-1. E. Corsini 1 , S. Birindelli 2 , M. Marinovich 1 , C. L. Galli 1 and C. Colosio 2 . 1 Pharmacological Sciences, University of Milan, Milan, Italy and 2 ICPS, International Centre for Pesticides and Health Risk Prevention, Busto Garolfo, Italy. #1889 ANALYSIS OF THE PROTEOMIC CHANGES INDUCED BY PROPANIL ON A MACROPHAGE CELL LINE. I. V. Ustyugova 1 , C. L. Walton 1 , K. M. Brundage 1,2 and J. B. Barnett 1,2 . 1 Proteomic Core Facility, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV and 2 Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV. #1890 ALTERED ACTIVATION OF T CELLS BY SILICA-EXPOSED ANTIGEN-PRESENTING CELLS. C. T. Migliaccio and A. Holian. Ctr for Environ Health Sciences/Biomed Pharmacology Sciences, University of Montana, Missoula, MT. #1891 ROLE OF NEUTROPHILS IN 1- NITRONAPHTHALENE-INDUCED PULMONARY INJURY AND REPAIR. L. Pantle, M. Fanucchi and C. Plopper. University of California, Davis, Davis, CA. #1892 PARTICULATE MATTER-INDUCED AIRWAY INFLAMMATION CORRELATES WITH IMMUNE ADJUVANT POTENTIAL. C. de Haar, I. Hassing, R. Bleumink and R. Pieters. Institute for Risk Assessment Sciences, Utrecht, Netherlands. #1893 IMMUNE RESPONSE OF HUMAN LYMPHOBLASTOID AND BRONCHIAL EPITHELIAL CELL LINES TO ORGANIC COMPOUNDS FROM FINE PARTICLES (PM2.5) IN PUERTO RICO. E. Fuentes-Mattei 1,3 , I. Rodriguez-Fernandez 2,3 , A. Gioda 3 , W. Delgado- Morales 1 and B. D. Jimenez Velez 1,3 . 1 Biochemistry, UPR Medical Sciences Campus, San Juan, Puerto Rico, 2 Biology, UPR Ponce Campus, Ponce, Puerto Rico and 3 Center of Environmental and Toxicological Research- UPR Medical Science Campus, San Juan, Puerto Rico. #1894 MURINE PULMONARY MACROPHAGE EXPRESSION AND PRODUCTION OF TNFA AND MIP-2 AFTER EXPOSURE TO DIESEL EXHAUST PARTICLES (DEP) AND EXTRACTS. T. Stevens 1 , M. Daniels 2 and I. Gilmour 2 . 1 UNC, Chapel Hill, NC and 2 EPA, Research Triangle Park, NC. #1895 IN-VITRO INFLAMMATORY AND CYTOTOXIC RESPONSES TO URBAN AIR FINE AND ULTRAFINE PARTICULATE SAMPLES COLLECTED DURING CONTRASTING POLLUTION SITUATIONS IN SIX EUROPEAN CITIES (PAMCHAR). P. Jalava 1,2 , R. O. Salonen 1 , A. I. Halinen 1 and M. Hirvonen 1 . 1 Department of Environmental Health, National Public Health Institute (KTL), Kuopio, Finland and 2 University of Kuopio, Kuopio, Finland. Sponsor: M. Viluksela. #1896 EXPRESSION AND KINETICS OF TOLL-LIKE RECEPTORS AND INFLAMMATORY CYTOKINE SECRETION IN MURINE ALVEOLAR MACROPHAGES. K. M. Gowdy 2,1 , M. Daniels 1 , E. Boykin 1 and M. Gilmour 1 . 1 Environmental Toxicology Division, U.S. EPA, Research Triangle Park, NC and 2 North Carolina State University, Raleigh, NC. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: LIVER II Chairperson(s): Martin Ronis, University of Arkansas Medical Sciences, Little Rock, AR. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1897 IMPROVED RAT MODELS FOR PREDICTIVE TOXICOLOGY. S. Nye, N. Cozzi, J. Baye, A. Wittenburg, S. Korb, Y. Evrard, R. Roman and H. Jacob. Research & Development, PhysioGenix, Inc., Wauwatosa, WI. Sponsor: Y. Dragan. #1898 IN VIVO HEPATIC CELL PROLIFERATION IS AN EARLY, SENSITIVE MARKER OF HEPATOTOXICITY. S. Turner 1 , J. Gardner 1 , J. Stark 1 , D. Buffmum 2 and M. Hellerstein 3,2,1 . 1 Research, Kinemed Inc., Emeryville, CA, 2 Medicine, UC San Francisco, San Francisco, CA and 3 Nutritional Sciences and Toxicology, UC Berkeley, Berkeley, CA. Sponsor: I. Heyman. #1899 INVESTIGATIONS OF THE EFFECTS ON PROTEIN EXPRESSION INDUCED BY HEPATOTOXICANTS ON PRIMARY CULTURED RAT HEPATOCYTES. T. Yamamoto, T. Fukushima, R. Kikkawa, H. Yamada and I. Horii. Worldwide Safety Sciences, Pfizer Japan Inc., Taketoyo, Aichi, Japan. Sponsor: M. Kurata. #1900 PROTEOMIC ANALYSIS OF LIVER AND SERUM FROM LIPOSACCHARIDE TREATED RATS DURING ACUTE INFLAMMATION. J. H. Madenspacher 1 , M. E. Bruno 1 , B. A. Wetmore 1 , R. Pieper 2 , C. L. Gatlin 2 , A. J. Makusky 2 , A. M. McGrath 2 , M. Zhao 2 , J. Zhou 2 , J. Taylor 2 , S. Steiner 2 , R. W. Tennant 1 , K. B. Tomer 1 and B. A. Merrick 1 . 1 National Center for Toxicogenomics, NIEHS, Research Triangle Pk, NC and 2 Proteomics Division, Large Scale Biology Corporation, Research Triangle Pk, NC. #1901 EVALUATION OF THE BACKGROUND DATA OBTAINED IN THE TOXICOGENOMICS PROJECT IN JAPAN. H. Nitta, T. Miyazaki, H. Totsuka, T. Miyagishima, T. Urushidani and T. Nagao. Toxicogenomics Project, National Institute of Health Sciences, Tokyo, Japan. Sponsor: T. Inoue. #1902 THIOACETAMIDE AND METHAPYRILENE SHOWED A UNIQUE GENE EXPRESSION PROFILE AMONG THE CHEMICALS IN THE TOXICOGENOMICS PROJECT IN JAPAN. Y. Mizukawa, T. Miyagishima, T. Urushidani and T. Nagao. Toxicogenomics Project, National Institute of Health Sciences, Tokyo, Japan. Sponsor: T. Inoue. WEDNESDAY up-to-date information at www.toxicology.org 193
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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