Program - Society of Toxicology

More documents

Recommendations

Info

44 th Annual Meeting and ToxExpo Program Description TUESDAY #783 ORAL DOSING WITH N-ACETYL-L-CYSTEINE SIGNIFICANTLY INCREASES GLUTATHIONE LEVELS AND GLUTATHIONE-S-TRANSFERASE ACTIVITY IN RAT SKIN. E. Wilfong, A. J. Bobb, E. W. Johnson, S. L. Lohrke, R. H. Casavant and D. P. Arfsten. Naval Health Research Center Detachment Environmental Health Effects Laboratory, Wright- Patterson AFB, OH. #784 TOPICAL IODINE SUPPRESSES SULFUR- MUSTARD-INDUCED TUMOR NECROSIS FACTOR-ALPHA INDUCTION IN MOUSE-EAR MODEL. U. Wormser 1 , B. Brodsky 1 , E. Proscura 1 , J. F. Foley 2 , T. Jones 2 and A. Nyska 2 . 1 Pharmacology, The Hebrew University, Jerusalem, Israel and 2 Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, NC. #785 DEVELOPMENT OF INTERSPECIES AND MULTI-EXPOSURE ROUTE DOSE METRICS FOR SARIN VIA PHYSIOLOGICALLY BASED PHARMACOKINETIC/PHARMACODYNAMIC MODELLING. J. Gearhart 1 , K. Yu 2 , P. Robinson 1 , E. Jakubowski 3 , R. Mioduszewski 3 , C. Whalley 3 , S. Thompson 3 , T. Shih 4 , L. Lumley 4 and J. McDonough 4 . 1 ManTech Environmental Technology, Inc., Wright- Patterson AFB, OH, 2 AFRL/HEPB, Wright-Patterson AFB, OH, 3 US Army Edgewood Chem Bio Center, Aberdeen Proving Ground, MD and 4 US Army MRICD, Aberdeen Proving Ground, MD. #786 A PBPK REGIONAL MODEL FOR NERVE AGENTS IN THE BRAIN. P. J. Robinson 1 , J. M. Gearhart 1 , K. O. Yu 1 , E. M. Jakubowski 2 , R. J. Mioduszewski 2 and S. A. Thomson 2 . 1 Wright-Patterson AFB, Dayton, OH and 2 Edgewood Chemical Biological Center, Aberdeen, MD. #787 SARIN (GB) REGENERATION AND CHOLINESTERASE PROFILES FOLLOWING INHALATION OF GB IN GUINEA PIGS: APPLICATION TO PBPK MODELING. C. E. Whalley 1 , L. A. Lumley 2 , E. M. Jakubowski 1 , J. McGuire 3 , C. Krauthauser 3 , D. Miller 3 , R. Evans 3 , T. Belski 3 , J. Renner 3 , J. Anthony 1 , C. Crouse 3 , J. Scotto 1 , J. Jarvis 1 , A. Totura 3 , M. O’Malley 2 , A. D’Ambrozio 2 , C. Robison 2 , E. Mason 2 , S. McAvoy 2 , T. Rowland 2 , C. Clark 2 , J. H. McDonough 2 , R. J. Mioduszewski 1 , T. M. Shih 2 and S. A. Thomson 1 . 1 ECBC, Aberdeen Proving Ground, MD, 2 USAMRICD, Aberdeen Proving Ground, MD and 3 Geo-Centers, Aberdeen Proving Ground, MD. #788 ESTIMATING LETHAL AND SEVERE TOXIC EFFECTS IN MINIPIGS FOLLOWING 10, 60 AND 180-MINUTES OF WHOLE-BODY GB VAPOR EXPOSURE. S. W. Hulet 1 , D. R. Sommerville 1 , P. A. Dabisch 2 , B. J. Benton 1 , D. B. Miller 2 , J. S. Forster 1 , J. A. Scotto 1 , R. B. Crosier 1 , C. L. Krauthauser 2 , J. R. Jarvis 2 , J. H. Manthei 1 , W. T. Muse 1 , D. C. Burnett 1 , R. A. Moretz 1 , B. P. Gaviola 1 , R. J. Mioduszewski 1 and S. A. Thomson 1 . 1 Toxicology, US Army ECBC, Aberdeen Proving Grounds, MD and 2 GEO-Centers, Inc., Abingdon, MD. #789 PRETREATMENT WITH CARBOXYESTERASE INHIBITOR CBDP SENSITIZES MICE TO SARIN: POTENTIAL MODEL FOR LOW-DOSE EXPOSURE ASSESSMENT. R. D. Grubbs, W. A. Price, J. B. Lucot and M. Morris. Pharmacology & Toxicology, Wright State University School of Medicine, Dayton, OH. #790 GENISTEIN PROTECTS MICE FROM RADIATION-INDUCED WEIGHT LOSS. M. R. Landauer, J. Kramer, C. Pham and V. Srinivasan. AFRRI, Bethesda, MD. #791 LOW DOSE SARIN PRODUCES LONG LASTING CHANGES IN CARDIOVASCULAR FUNCTION. V. Farah, S. J. Paton and M. Morris. Pharmacology and Toxicology, Wright State University, Dayton, OH. Sponsor: J. McDougal. #792 EVIDENCE OF CYSTEINE LOADING IN SKIN AND OTHER TISSUES IN SPRAGUE-DAWLEY RATS DOSED AT 4-HOUR INTERVALS WITH N- ACETYL-L-CYSTEINE (1, 200 MG/KG). E. W. Johnson, E. R. Wilfong, A. J. Bobb and D. P. Arfsten. NHRC EHE Lab., Wright-Patterson AFB, OH. #793 LOW-LEVEL INHALATION EXPOSURE TO GB, GF AND VX INDUCES EXPRESSION OF NEURONAL APOPTOSIS AND REGENERATION GENES IN RAT. J. W. Sekowski 1 , J. Bucher 1 , M. Orehek 1 , M. Horsmon 1 , J. J. Valdes 1 , C. Whalley 1 , B. Benton 1 , W. Muse 1 , D. Miller 1 , J. Scotto 1 , J. Forster 1 , J. Manthei 1 , R. Way 1 , D. Burnett 1 , B. Gaviola 1 , R. Mioduszewski 1 , S. Thomson 1 , M. Nau 2 and M. Vahey 2 . 1 Edgewood Chemical Biological Center, US Army RDECOM, APG-EA, MD and 2 Walter Reed Army Institute of Research, US Army MRMC, Rockville, MD. #794 MECHANISM OF THE MIOTIC TOLERANCE OBSERVED FOLLOWING MULTIPLE EXPOSURES TO SARIN VAPOR. P. A. Dabisch 2,1 , D. B. Miller 3 , D. C. Burnett 1 , E. M. Jakubowski 1 , S. A. Reutter 1 , R. J. Mioduszewski 1 and S. Thomson 1 . 1 Operational Toxicology, US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 2 National Research Council Postdoctoral Associate, National Academy of Sciences, Washington, DC and 3 Geo-Centers, Inc., Aberdeen Proving Ground, MD. #795 THE URINE CONCENTRATIONS OF 2-AMINO-2- THIAZOLINE-4- CARBOXYLIC ACID AS A BIOMARKER FOR CYANIDE IN SMOKING AND NON-SMOKING MALE AND FEMALE VOLUNTEERS. B. A. Logue 1 , S. I. Baskin 2 , G. A. Rockwood 2 , N. P. Kirschten 2 , S. Royster 2 , M. Keebaugh 2 and G. E. Platoff 2 . 1 Drug Assessment, USAMRICD, Aberdeen Proving Ground, MD and 2 South Dakota State University, Brookings, SD. #796 INTERACTION OF 2-AMINO-2-THIOZOLINE-4- CARBOXYLIC ACID WITH CYTOCHROME C OXIDASE IMMOBILIZED IN AN ELECTRODE- SUPPORTED LIPID BILAYER MEMBRANE. J. B. Kelly 2 , F. M. Hawkridge 2 , S. I. Baskin 1 , G. A. Rockwood 1 and G. E. Platoff. 1 USAMRICD, Aberdeen Proving Ground, MD and 2 Chemistry, Virginia Commonwealth University, Richmond, VA. 110 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description Tuesday Morning, March 8 9:30 AM to 12:30 PM Exhibit Hall POSTER SESSION: SAFETY EVALUATION-BIOTECHNOLOGY PRODUCTS AND VACCINES Displayed: 9:30 AM–12:30 PM Attended: 11:00 AM–12:30 PM #797 VALIDATION OF REAL TIME QUANTITATIVE PCR AND SAMPLE PREPARATION PROCEDURE IN BIODISTRIBUTION STUDY OF ADENOVIRUS VECTORS. B. Tian, S. S. Rentz, G. S. Gregory, R. Tina and J. G. Page. Southern Research Institute, Birmingham, AL. #798 SINGLE-DOSE TOXICITY STUDY OF AN ONCOLYTIC ADENOVIRUS ADMINISTERED BY INTRAVENOUS INFUSION TO CYNOMOLGUS MONKEYS. B. McIntyre 1 , S. Thibault 1 , N. Kishnani 2 , D. Compton 1 , R. Veneziale 1 , J. Nelson 3 , R. Ralston 4,2 and R. Morrissey 1 . 1 Schering-Plough Research Institute, Lafayette, NJ, 2 Schering-Plough Research Institute, Kenilworth, NJ, 3 Charles River Laboratories, Sierra Division, Sparks, NV and 4 Canji, San Diego, CA. #799 FIFTEEN-MONTH REPEATED DOSE SUBCUTANEOUS ADMINISTRATION STUDY OF RHFGF-2 IN ATHYMIC NUDE MICE. S. Tsunoda 1 , T. Nakamura 1 , T. Sibanushi 1 , K. Kuzutani 1 and M. Takahashi 2 . 1 Safety Research Department, Kaken Pharmaceutical co., Ltd., Sizuoka, Japan and 2 Pathology Peer Review Center, Tokyo, Japan. #800 PRECLINICAL SAFETY OF RECOMBINANT HUMAN THROMBIN. J. K. Heffernan, R. Ponce, L. A. Zuckerman, J. Visich and M. Rogge. Preclinical Development, ZymoGenetics, Seattle, WA. #801 SAFETY ASSESSMENT OF MONOCLONAL ANTIBODY MAB216 + VINCRISTINE IN RABBITS. K. Steinmetz 1 , D. Fairchild 1 , N. Teng 2 , M. Bieber 2 , K. Schweikart 3 , J. Tomaszewski 3 and J. Mirsalis 1 . 1 SRI International, Menlo Park, CA, 2 3 Stanford University, Stanford, CA and National Cancer Institute, Bethesda, MD. #802 RISING DOSE TOLERABILITY STUDIES OF A CHIMERIC ANTI-PHOSPHATIDYLSERINE MONOCLONAL ANTIBODY (TARVACIN) IN RATS AND CYNOMOLGUS MONKEYS. S. Carpenter 1 , C. Stewart 2 , L. Willis 2 and P. E. Thorpe 3 . 1 2 Peregrine Pharmaceuticals, Inc., Tustin, CA, MPI Research, Inc., Mattawan, MI and 3 The University of Texas Southwestern, Dallas, TX. #803 SAFETY EVALUATION OF A CHIMERIC ANTI- PHOSPHATIDYLSERINE MONOCLONAL ANTIBODY (TARVACIN) IN MICE USING A FULL-THICKNESS EXCISIONAL DERMAL WOUND MODEL. S. Carpenter 1 , T. Nguyen 2 and P. E. Thorpe 3 . 1 Peregrine Pharmaceuticals, Inc., Tustin, CA, 2 Explora Biolabs, LLC, La Jolla, CA and 3 The University of Texas Southwestern, Dallas, TX. Sponsor: L. Kamendulis. #804 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS OF AVASTIN, A MONOCLONAL ANTIBODY AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR. C. L. Zuch 1 , A. Bricarello 2 , J. C. Beyer 1 , P. J. Thomford 3 , B. J. Christian 3 and A. M. Hoberman 4 . 1 Safety Assessment, Genentech, Inc., South San Francisco, CA, 2 Study Management, Genentech, Inc., South San Francisco, CA, 3 Covance Laboratories, Inc., Madison, WI and 4 Charles River Laboratories, Inc., Argus Research Division, Horsham, PA. #805 ACUTE TOXICITY STUDIES WITH A TRANSFORMING GROWTH FACTOR-BETA ANTAGONIST IN SPRAGUE-DAWLEY RATS AND CYNOMOLGUS MONKEYS. E. R. LaCasse, R. Pawliuk, J. DelCarpini, C. Rogers and L. Andrews. Pharmacology/Toxicology, Genzyme, Framingham, MA. #806 SAFETY EVALUATION OF A HUMAN FUSION PROTEIN PRO97796 (BR3-FC). T. R. Gelzleichter 1 , T. Kamenosono 2 , D. M. Danilenko 1 , S. Ren 1 , A. Song 1 , S. R. Brignoli 1 , T. M. Watson 1 and Y. Vugmeyster 1 . 1 2 Genentech, South San Francisco, CA and SNBL, USA, Seattle, WA. #807 CJC-1295, A LONG-ACTING GROWTH HORMONE RELEASE FACTOR ANALOGUE, IS WELL TOLERATED IN DOGS UP TO 14 DAYS. V. Iordanova 1 , S. Wen 1 , B. Lawrence 1 , C. N. Papagiannis 2 , S. Morseth 3 and J. Castaigne 1 . 1 ConjuChem, Inc., Montreal, QC, Canada, 2 MPI Research, Inc., Mattawan, MI and 3 Morseth Consulting LLC, Jefferson, MD. #808 RODENT SUBCHRONIC TOXICITY STUDIES WITH THE PEPTIDE ANTIBIOTIC XMP.629. R. Hawks 1 , S. W. Frantz 2 , J. T. Secrest 2 and K. E. Meyer 1 . 1 2 XOMA LLC, Berkeley, CA and MPI Research, Mattawan, MI. #809 SAFETY AND EFFICACY OF GLYCOSYLATED UNDENATURED TYPE II COLLAGEN (UC-II) IN OBESE-ARTHRITIC DOGS. R. C. Gupta 1 , L. DeParle 1 , T. Canerdy 1 , J. Goad 1 , M. Bagchi 2 and D. Bagchi 2 . 1 Toxicology, Murray State university, Hopkinsville, KY and 2 InterHealth Nutraceuticals Inc., Benicia, CA. #810 PRECLINICAL SAFETY ASSESSMENT OF RECOMBINANT PLAGUE VACCINE (RF1V) FOLLOWING REPEAT-DOSE ADMINISTRATION. R. V. House 1 , J. Shearer 1 , S. Manetz 2 and S. Morris 1 . 1 DynPort Vaccine Company LLC, Frederick, MD and 2 Gene Logic Laboratories, Gaithersburg, MD. #811 PRECLINICAL SAFETY ASSESSMENT OF RECOMBINANT BOTULINUM VACCINE A/B (RBV A/B) FOLLOWING REPEAT-DOSE ADMINISTRATION. J. Shearer 1 , I. Henderson 1 , S. Manetz 2 and R. V. House 1 . 1 DynPort Vaccine Company LLC, Frederick, MD and 2 Gene Logic Laboratories. Inc., Gaithersburg, MD. TUESDAY up-to-date information at www.toxicology.org 111
Page 1 and 2:
44 th Annual Meeting & ToxExpo TM P
Page 3 and 4:
Contents Program Overview .........
Page 5 and 6:
Annual Meeting Events Calendar (Con
Page 7 and 8:
Annual Meeting Events Calendar (Con
Page 9 and 10:
44 th Annual Meeting and ToxExpo Ne
Page 11 and 12:
44 th Annual Meeting and ToxExpo Co
Page 13 and 14:
Sheraton Hotel Map 44 th Annual Mee
Page 15 and 16:
Itinerary Planner Computer Stations
Page 17 and 18:
2005 Exhibitors (Continued) 44 th A
Page 19 and 20:
44 th Annual Meeting and ToxExpo To
Page 21 and 22:
44 th Annual Meeting and ToxExpo Ex
Page 23 and 24:
General Information 44 th Annual Me
Page 25 and 26:
44 th Annual Meeting and ToxExpo Ge
Page 27 and 28:
44 th Annual Meeting and ToxExpo Ge
Page 29 and 30:
2005 Award Winners The Society of T
Page 31 and 32:
2005 Award Winners (Continued) Enha
Page 33 and 34:
2004 Student Award Winners Colgate-
Page 35 and 36:
44 th Annual Meeting and ToxExpo Sc
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
INTERNATIONAL HARMONIZATION OF TECH
Page 49 and 50:
Saturday Afternoon, March 5 2:00 PM
Page 51 and 52:
44 th Annual Meeting and ToxExpo Pr
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62: 44 th Annual Meeting and ToxExpo Pr
Page 111: 44 th Annual Meeting and ToxExpo Pr
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
44 th Annual Meeting and ToxExpo #1
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Author Index 44 th Annual Meeting a
Page 229 and 230:
Author Index (Continued) 44 th Annu
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
SOT Affiliates for 2005 44 th Annua
Page 249 and 250:
44 th Annual Meeting and ToxExpo 20
Page 251 and 252:
Headquarters Staff 44 th Annual Mee
Page 253 and 254:
44 th Annual Meeting and ToxExpo Ap
Page 255 and 256:
44 th Annual Meeting and ToxExpo Of
Page 257 and 258:
44 th Annual Meeting and ToxExpo So
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
up-to-date information at www.toxic
Page 267 and 268:
44 th Annual Meeting and ToxExpo To
Page 269:
44 th Annual Meeting & ToxExpo TM M
show all

Program - Society of Toxicology

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?