Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
#989 HETEROGENEOUS SENSITIVITY OF THE
EMBRYONIC NERVOUS SYSTEM TO THE
GENOTOXIC AGENT BRDU IN MICE. M.
Kuwagata 1,2 , T. Ogawa 2 , K. T. Muneoka 2 , H. Ono 1 and
S. Shioda 2 . 1 Toxicology, Hatano Research Institute,
Food and Drug Safety Center, Kanagawa, Japan and
2 Anatomy, Showa University School of Mrdicine,
Tokyo, Japan.
Tuesday Morning, March 8
9:45 AM to 10:45 AM
Room 223
INFORMATIONAL SESSION: EXPRESSION PROFILING WITH
BEADARRAY TM TECHNOLOGY: IDENTIFICATION OF GENES
INDUCED BY LOW LEVEL OXIDATIVE STRESS — PRESENTED BY
ILLUMINA
We examined variability in bead-based oligonucleotide microarrays by evaluation
of dispersion characteristics among hybridization and biological replicate
samples of lymphocyte RNA. Using a consecutive sampling and coincidence
test, we have identified genes whose expression was significantly altered by low
level exposure to oxidative stress.
Tuesday Morning, March 8
9:45 AM to 10:45 AM
Room 215
INFORMATIONAL SESSION: TOXICITY TESTING: WHAT BONE
MARROW CAN TELL US — PRESENTED BY STEMCELL
TECHNOLOGIES, INC.
Over the past three decades, a spectrum of standardized assays has been developed
to characterize and measure bone marrow function and assess the multiple
cell lineages it contains. In humans, bone marrow is one of the five major organ
systems most sensitive to chronic low-dose chemical toxicants, making it an
important target to assess in toxicity screening. This session will illustrate the
rationale for targeting bone marrow for drug toxicity screening, assays that are
employed and importance of using primary human cells in functional cell-based
assays.
Tuesday Morning, March 8
11:00 AM to 12:00 NOON
Room 223
Tuesday Morning, March 8
11:00 AM to 12:00 NOON
Room 215
INFORMATIONAL SESSION: SEARCHING THE NTP DATABASES —
PRESENTED BY NIEHS
The National Toxicology Program (NTP) conducts studies on potentially toxic
agents to determine their impact on human health. Enhancing public access to
these data, this workshop provides information about what is available within
the NTP databases, using real examples to demonstrate the search process.
Tuesday Afternoon, March 8
12:00 NOON to 1:15 PM
La Louisiane Ballroom A
Tuesday Afternoon
IN VITRO TOXICOLOGY LECTURE: USING IN VITRO
TOXICOLOGY TO PROTECT HUMAN HEALTH AND ADVANCE
ANIMAL WELFARE
Lecturer: William S. Stokes, DVM, NIEHS, Research Triangle Park, NC.
Sponsored by:
The Colgate-Palmolive Company
This lecture will discuss the application of in vitro toxicology to regulatory
safety assessment and provide examples of how recently adopted in vitro test
methods have benefited animal welfare by refining and reducing animal use
while providing for the protection of human heath. The process by which new
technological methods evolve from development to regulatory acceptance will
be discussed, including the validation process necessary to determine their
usefulness and limitations for defined specific purpose. Dr. Stokes will also
discuss expected opportunities for an expanded role for in vitro toxicology in an
integrated approach to safety assessment.
Students register for this event on the Annual Meeting Registration form; a $5
deposit per ticket is required and will be exchanged for the ticket at the
luncheon. Seating is limited.
INFORMATIONAL SESSION: DESIGNING BETTER PRECLINICAL
STUDIES USING GENE EXPRESSION ANALYSIS — PRESENTED BY
GENE LOGIC
Understanding the expression pattern of a target protein in various tissues can
help you plan your small molecule and biologics safety studies with more precision
by suggesting additional target tissues and potential areas for concern. In
this presentation, you will hear case studies on how scientists can use Gene
Logic’s web-based ASCENTA System to design better preclinical studies.
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SOT’s 44 th Annual Meeting