Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description MONDAY #337 3:10 A FLOW CYTOMETRIC PROCESS FOR DETECTING ANEUGENIC AGENTS IN VITRO. P. A. Muehlbauer and M. J. Schuler. Genetic Toxicology, Pfizer Global R & D, Groton, CT. #338 3:40 HIGH-THROUGHPUT SCREENING USING STRESS-RESPONSIVE REPORTER GENE ASSAYS. R. Brennan 1 and J. D. Haley 2 . 1 Toxicology, Iconix Pharmaceuticals Inc., Mountain View, CA and 2 Cancer Cell Biology, OSI Pharmaceuticals Inc., Farmingdale, NY. Abstract 339 is located on page 69. Monday Afternoon, March 7 1:30 PM to 4:30 PM Room RO1 PLATFORM SESSION: COMPUTATIONAL TOXICOLOGY: ADVANCES AND APPLICATIONS Chairperson(s): Melvin Andersen, CIIT Centers for Health Research, Research Triangle Park, NC and Kannan Krishnan, Université de Montréal, Montreal, QC, Canada. #344 1:30 BIOLOGICALLY-BASED MATHEMATICAL MODEL FOR GENE EXPRESSION DUE TO JP-8 EXPOSURE TO SKIN. J. N. McDougal 1 , C. M. Garrett 1 , C. A. Amato 1 , Y. Zheng 2 , Q. Zhang 3 and R. B. Conolly 3 . 1 Department of Pharmacology & Toxicology, Wright State University School of Medicine, Dayton, OH, 2 Department of Biomedical Engineering, Purdue University, West Lafayette, IN and 3 Center for Computational Systems Biology and Human Health Assessment, CIIT Centers for Health Research, Research Triangle Park, NC. #345 1:50 MODELLING THE RELATIONSHIP BETWEEN NICKEL AND CHROMIUM EXPOSURE AND CONTACT DERMATITIS. S. Franks and A. Jones. Health and Safety Laboratory, Buxton, United Kingdom. Sponsor: R. Conolly. #346 2:10 COMPUTATIONAL MODELS FOR THE ACQUISITION OF NEOCORTICAL NEURONS IN THE DEVELOPING HUMAN, MONKEY, AND MOUSE: CROSS SPECIES COMPARISON OF TOXICODYNAMICS. J. M. Gohlke, W. C. Griffith and E. M. Faustman. Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. #347 2:30 MAGNETIC RESONANCE IMAGING AND COMPUTATIONAL FLUID DYNAMICS SIMULATIONS OF RABBIT NASAL AIRFLOWS FOR HYBRID CFD/PBPK MODELING OF METHYL IODIDE. H. E. Trease 1 , K. R. Minard 1 , L. L. Trease 1 , R. A. Corley 1 , J. S. Kimbell 2 , J. R. Harkema 3 , J. H. Kinzell 4 and M. L. Gargas 5 . 1 Battelle Northwest, Richland, WA, 2 CIIT Centers for Health Research, Research Triangle Park, NC, 3 Michigan State University, East Lansing, MI, 4 Arvesta Corp., San Francisco, CA and 5 The Sapphire Group, Beavercreek, OH. #348 2:50 IN SILICO PHARMACOGENETIC ANALYSIS OF R-WARFARIN METABOLISM. Y. Guo 1 , P. Cheung 2 , J. Wang 1 , G. Liao 1 , J. Usuka 1 , M. Masjedizadeh 3 , P. Weller 2 and G. Peltz 1 . 1 Genetics & Genomics, Roche Palo Alto, Palo Alto, CA, 2 DMPK, Roche Palo Alto, Palo Alto, CA and 3 Chemical Services, Roche Palo Alto, Palo Alto, CA. #349 3:10 AN INTEGRATED QSAR-PBPK MODEL FOR SIMULATING PHARMACOKINETICS OF CHEMICALS IN MIXTURES. K. Price and K. Krishnan. Occupational and Environmental Health, Universite de Montreal, Montreal, QC, Canada. #350 3:30 ISSUES IN THE USE OF PBPK MODELING IN THE DEVELOPMENT OF CANCER SLOPE FACTORS FOR PERCHLOROETHYLENE. J. E. Kester, P. Gentry, T. R. Covington and H. J. Clewell. ENVIRON Health Sciences Institute, Ruston, LA. #351 3:50 NEW APPLICATIONS FOR THE LEAD PBPK MODEL. S. M. Hays. Summit Toxicology, Lyons, CO. Sponsor: D. Pyatt. #352 4:10 CAN HYDROGEN CYANIDE POISONING BE DETECTED IN EXHALED AIR? G. Johanson, K. Stamyr and P. Nord. Work Environment Toxicology, Karolinska Institute, Stockholm, Sweden. Monday Afternoon, March 7 1:30 PM to 4:30 PM Room RO3 PLATFORM SESSION: BIOTRANSFORMATION/CYTOCHROME P450 Chairperson(s): Ernest Hodgson, North Carolina State University, Raleigh, NC and Burhan Ghanayem, NIEHS, Research Triangle Park, NC. #353 1:30 LARGE-SCALE GENE EXPRESSION PROFILING IN RATS IDENTIFIES MANY NOVEL CYP1A1 INDUCERS AND AH RECEPTOR LIGANDS. W. Hu 1 , M. R. Fielden 1 , D. Baston 2 , B. Zhao 2 , Y. Song 2 , J. Bohonowych 2 , A. Soshilov 2 , D. DeGroot 2 , C. Sorrentino 2 , M. Denison 2 and K. Kolaja 1 . 1 Chemogenomics and Toxicology, Iconix Pharmaceuticals Inc., Mountain View, CA and 2 Department of Environmental Toxicology, University of California Davis, Davis, CA. #354 1:50 EFFECTS OF FLAVONOIDS ON CYP1 EXPRESSION IN RL95-2 ENDOMETRIAL CANCER CELLS. Z. R. Master 1 , T. R. Sutter 2 and K. L. Willett 1 . 1 Pharmacology and Environmental Toxicology Research Program, University of Mississippi, University, MS and 2 W. Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN. #355 2:10 REDUCTION OF OBESITY IS ASSOCIATED WITH INCREASED HEPATIC CYP3A EXPRESSION IN WOMEN. D. Springer 1 , T. I. Leakey 1 , R. J. Feuers 1 , C. Buffington 2 , G. S. Cowan 2 and J. E. Leakey 1 . 1 OSC, NCTR, Jefferson, AR and 2 Department of Surgery, University of Tennessee, Memphys, TN. 74 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #356 #357 #358 #359 #360 #361 Monday 1:30 PM Room RO2 PLATFORM Chairperson(s): Richmond, #362 2:30 2:50 3:10 3:30 3:50 4:10 Afternoon, to 4:30 SESSION: VA and 1:30 BIPHENYL PROPARGYL ETHERS AS #363 1:52 THE ROLE OF CYCLIN DEPENDENT KINASE INHIBITORS OF CYP 1A1, CYP 1A2, AND CYP INHIBITOR P21 IN TCDD-INDUCED THYMIC 2B1. N. E. Hopkins 1 , B. Bowman 2 , T. Smith 2,1 , C. ATROPHY. M. Fisher 1 , M. Nagarkatti 2 and P. S. DeCuir-Charbonnet 1 , A. Henderson 1 and M. Nagarkatti 1,2 . 1 Pharmacology and Toxicology, Virginia Foroozesh 2 . 1 Cell & Molecular Biology, Tulane Commonwealth University School of Medicine, University, New Orleans, LA and 2 Chemistry, Xavier Richmond, VA and 2 Microbiology and Immunology, University, New Orleans, LA. Virginia Commonwealth University School of Medicine, Richmond, VA. USE OF A HUMAN HEPATOCYTE-DERIVED CELL LINE TO SIMULTANEOUSLY ASSESS #364 2:14 TCDD SUPPRESSES ANTIGEN-SPECIFIC CYP3A4 INDUCTION AND TIME-DEPENDENT INTERACTIONS BETWEEN OTII CD4 T CELLS INHIBITION. S. L. Ripp 1 , K. A. Trevena 1 , D. R. AND OVA-LOADED DENDRITIC CELLS. S. Gibbons 2,1 and J. B. Mills 1 . 1 Pharmacokinetics, Navarro 1 and D. M. Shepherd 1,2 . 1 CEHS, University of Dynamics, & Metabolism, Pfizer Global Research & Montana, Missoula, MT and 2 Biomedical & Development, Groton, CT and 2 Michigan State Pharmaceutical Sciences, University of Montana, University, East Lansing, MI. Missoula, MT. HUMAN NAPHTHALENE METABOLISM. T. M. #365 2:36 SUPERANTIGEN-PRIMED T CELLS EXPOSED Cho, R. L. Rose and E. Hodgson. Environmental & TO 2, 3, 7, 8-TETRACHLORODIBENZO-P- Molecular Toxicology, North Carolina State University, DIOXIN (TCDD) UNDERGO APOPTOSIS Raleigh, NC. DURING THE FIRST ENCOUNTER AND EXHIBIT ANERGY UPON RESTIMULATION ROLE OF PULMONARY CYTOCHROME P450 WITH THE ANTIGEN. L. Faulconer 2 , I. Camacho 1 3A1 IN 1-NITRONAPHTHALENE M. Nagarkatti 1 and P. Nagarkatti 2 . 1 Microbiology and BIOACTIVATION AND INJURY IN ADULT AND Immunology, Virginia Commonwealth University, POSTNATAL RATS. K. C. Day, J. D. Reynolds, D. R. Richmond, VA and 2 Pharmacology and Toxicology, Morin, C. G. Plopper and M. V. Fanucchi. University of Virginia Commonwealth University, Richmond, VA. California, Davis, Davis, CA. #366 2:58 B CELL MATURATION AND TCDD-INDUCED MODIFICATION OF PULMONARY CYP2B1 AND MODULATION OF THE 3’α ENHANCER. C. E. INDUCED CYP1A1 ACTIVITIES BY Sulentic. Pharmacology&Toxicology, Wright State INTRAVENOUS INJECTION OF IRON DEXTRAN. M. M. Ghanem 1,2 , L. Battelli 1 University, Dayton, OH. , M. Barger 1 , J. Nath 2 and A. F. Hubbs 1 . 1 HELD, NIOSH, #367 3:20 SYNTHETIC AND ENDOGENOUS PPARγ CDC, Morgantown, WV and 2 Genetics and AGONISTS, GW7845, 15-DEOXY-∆ 12, 14 - Developmental Biology Program, WVU, Morgantown, PROSTAGLANDIN J 2 , AND MONO-(2- WV. Sponsor: V. Castranova. ETHYLHEXYL) PHTHALATE, ACTIVATE COMPLEX CASPASE CASCADES IN PRO/PRE-B ROLE OF CYP2E1 IN THE OXIDATION OF CELLS. J. Schlezinger, J. Emberley and D. Sherr. ACRYLAMIDE (AA) TO GLYCIDAMIDE (GA) Environmental Health, Boston University School of AND FORMATION OF DNA AND HEMOGLOBIN ADDUCTS. B. I. Ghanayem 1 , L. McDaniel 2 Public Health, Boston, MA. , M. I. Churchwell 2 , N. C. Twaddle 2 , R. Snyder 3 , T. R. Fennell 3 #368 3:42 CB2 CANNABINOID RECEPTOR AGONIST, and D. R. Doerge 2 . 1 Laboratory of Pharmacology and JWH015 TRIGGERS APOPTOSIS IN IMMUNE Chemistry, NIEHS/NIH, Research Triangle Park, NC, CELLS: POTENTIAL ROLE FOR CB2 2 3 NCTR, Jefferson, AR and RTI International, Research SELECTIVE LIGANDS AS Triangle Park, NC. IMMUNOSUPPRESSIVE AGENTS. C. A. Lombard M. Nagarkatti 1 and P. S. Nagarkatti 2 . 1 Microbiology and Immunology, MCV Campus, Virginia March 7 Commonwealth University, Richmond, VA and PM 2 Pharmacology and Toxicology, MCV Campus, Virginia Commonwealth University, Richmond, VA. MECHANISMS OF IMMUNOTOXICITY #369 4:04 THE ENDOGENOUS CANNABINOID, 2- ARACHIDONYL-GLYCEROL, SUPPRESSES NF- Mitzi Nagarkatti, Virginia Commonwealth University, AT NUCLEAR TRANSLOCATION AND David Shepherd, University of Montana, Missoula, MT. INTERFERON-γ PRODUCTION. B. L. Kaplan 1,2 , GENE EXPRESSION ALTERATIONS IN Ouyang 1 , C. E. Rockwell 1 , G. K. Rao 1,2 and N. E. IMMUNE SYSTEM PATHWAYS FOLLOWING Kaminski 1,2 . 1 Pharmacology and Toxicology, Michigan EXPOSURE TO IMMUNOSUPPRESSIVE State University, East Lansing, MI and 2 Center for CHEMICALS. R. M. Patterson 1 , N. Walker 1 , S. Integrative Toxicology, Michigan State University, East Baker 2 , T. Dickinson 2 , K. White 3 , D. Musgrove 3 , S. Lansing, MI. Harrison 1 and D. R. Germolec 1 . 1 NIEHS, Research Triangle Park, NC, 2 Illumina, Inc., San Diego, CA and 3 VCU, Richmond, VA. , 1 , Y. MONDAY up-to-date information at www.toxicology.org 75
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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Program - Society of Toxicology

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