Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
MONDAY
#519 USE OF IN VITRO TECHNOLOGIES AND
METABONOMICS IN THE STUDY OF
PHOSPHOLIPIDOSIS. C. E. Thomas 1 , J. M. Colet 2 ,
A. Meissner 2 , B. Halstead 1 , R. Morgan 1 , K. Kramer 2 ,
W. Dewe 3 and D. Monteith 1 . 1 Inv. Toxicology., Lilly
Research Labs, Greenfield, IN, 2 Inv. Toxicology., Lilly
Development Centre, Mont-Saint-Guibert, Belgium and
3 Statistics, Lilly Development Centre, Mont-Saint-
Guibert, Belgium.
#520 EVALUATION OF VITAMIN K AND VITAMIN K
EPOXIDE AS BIOMARKERS OF
COAGULOPATHY IN RAT SERUM UTILIZING
HPLC. K. A. Navetta, P. E. Quintas, M. D. Aleo and J.
L. Colangelo. Safety Sciences, Pfizer, Groton, CT.
#521 A MOLECULAR BASIS FOR THE PREDICTION
OF RENAL TUBULAR INJURY BY DRUG
SIGNATURES FOLLOWING SHORT-TERM
COMPOUND TREATMENT. M. Fielden, G.
Natsoulis and K. Kolaja. Chemogenomics and
Toxicology, Iconix Pharmaceuticals Inc., Mountain
View, CA.
#522 BIOMARKERS THAT CHARACTERIZE
FIBROSIS AND BILE DUCT HYPERPLASIA. A.
Vladimirova, R. Brennan, M. Fielden, K. Kolaja and C.
Pearson. Iconix Pharmaceuticals, Inc., Mountain View,
CA.
#523 MULTI-ADDUCT ANALYSIS OF GLOBIN FROM
MICE AND RATS AFTER INHALATION
EXPOSURE TO 1, 3-BUTADIENE. N. I. Georgieva 1 ,
G. Boysen 1 , P. B. Upton 1 , Y. Li 1 , V. Walker 2 and J. A.
Swenberg 1 . 1 ESE, UNC, Chapel Hill, NC and 2 Lovelace
Respiratory Research Institute, Albuquerque, NM.
#524 INTERACTIONS OF COMPLEX CHEMICAL
MIXTURES FROM CONTAMINATED
SEDIMENTS AT A SUPERFUND SITE. A.
Gillespie 1 , T. D. Phillips 1 , T. J. McDonald 2 , L. He 1 , G.
Zhou 2,1 and K. Donnelly 2,1 . 1 VIBS, Texas A&M
University, College Station, TX and 2 EOH, Texas A&M
University H.S.C., S.R.P.H., College Station, TX.
#525 CORRELATION OF HEXENAL-DERIVED DNA
BINDING WITH DETOXIFICATION AND DNA
REPAIR STATUS IN CULTURED CELLS. M. D.
Stout 1 , J. Nakamura 2 , G. Boysen 2 , M. W. Powley 2 and J.
A. Swenberg 1,2 . 1 Curriculum in Toxicology, University
of North Carolina, Chapel Hill, NC and 2 Environmental
Sciences and Engineering, University of North Carolina,
Chapel Hill, NC.
#526 COMPARISON OF PLASMA AND URINE
SAMPLES FROM ANIT-EXPOSED F344 RATS
USING NMR SPECTROSCOPY. D. Mahle 1 , N. J.
DelRaso 1 , S. C. Gustafson 2 , C. L. Leakeas 2 , M. P.
Westrick 1 , A. E. Neuforth 3 and N. V. Reo 3 .
1 AFRL/HEPB, US Air Force, Wright-Patterson AFB,
OH, 2 AFIT/ENG, US Air Force, Wright-Patterson AFB,
OH and 3 Wright State University, Fairborn, OH.
#527 USE OF METABOLOMICS TO IDENTIFY
BIOMARKERS OF BREVETOXIN EXPOSURE. A.
J. bourdelais 1 , J. Benson 2 , A. Higgins 3 , H. Mei 3 , K.
Powell 3 , K. Wang 3 , B. Tibbetts 2 and D. G. Baden 1 .
1 2 CMS, UNCW, Wilmington, NC, Lovelace Respiratory
Research Institute, Albuquerque, NM and 3 Icoria,
Research Triangle Park, NC.
#528 CAN LEVELS OF PLASMA TESTOSTERONE BE
USED TO PREDICT MALE SEXUAL MATURITY
IN RHESUS MONKEYS (MACACA MULATTA)?
M. D. Saunders, R. Davis, S. Fox and L. Earl.
Toxicology Operations, Huntingdon Life Sciences,
Huntingdon, United Kingdom. Sponsor: C. Hardy.
#529 ADMINISTRATION OF A MEK INHIBITOR
RESULTS IN TISSUE MINERALIZATION IN THE
RAT DUE TO DYSREGULATION OF
PHOSPHORUS AND CALCIUM HOMEOSTASIS.
A. P. Brown, C. Courtney, T. Carlson and M. Graziano.
Safety Sciences, Pfizer Global Research and
Development, Ann Arbor, MI.
#530 USE OF METABONOMIC ANALYSIS FOR
BIOMARKERS OF MUSCULOSKELETAL
SYNDROME IN RATS. F. Grzemski 1 , L. C. Robosky 2 ,
M. D. Reily 2 , D. Baker 2 , C. A. Lesch 3 , M. G. Evans 1 ,
D. F. Wells 1 and D. G. Robertson 3 . 1 Safety Sciences,
Pfizer, Ann Arbor, MI, 2 Discovery Technology, Pfizer,
Ann Arbor, MI and 3 Inflammation Pharmacology,
Pfizer, Ann Arbor, MI.
#531 INVESTIGATION OF A HEPATOTOXICITY
SCREENING SYSTEM IN PRIMARY CELL
CULTURE. R. Kikkawa, T. Yamamoto, T. Fukushima,
Y. Hamada, H. Yamada and I. Horii. PGRD Nagoya
Lab., Pfizer Japan Inc., Taketoyo, Aichi, Japan.
Sponsor: K. Masaaki.
#532 THE IDENTIFICATION OF POTENTIAL
VASCULITIS BIOMARKERS TARGETED
THROUGH SELDI SCREENING. C. Drupa 1 , J. L.
Colangelo 1 , R. A. Goldstein 1 , M. L. Mirsky 1 , R. M.
Leimgruber 2 , M. Cabonce 2 , P. W. Brown 2 and E.
Dalmasso 3 . 1 World Wide Safety Sciences, Pfizer,
Groton, CT, 2 World Wide Safety Sciences, Pfizer, St.
Louis, MO and 3 Ciphergen Biosystems, Inc., Fremont,
CA. Sponsor: M. Lawton.
#533 ALANINE AMINOTRANSFERASE ACTIVITY IN
THE FA2N-4 HEPATOCYTE CLONE. E. R. Jackson
and D. E. Amacher. Safety Sciences, Pfizer, Inc.,
Groton, CT.
#534 TOXICOLOGIC AND PATHOLOGIC
SURVEILLANCE OF SEARCH & RESCUE DOGS
DEPLOYED TO THE WORLD TRADE CENTER,
THE PENTAGON, AND THE STATEN ISLAND
FRESH KILLS LANDFILL SITES. W. K. Rumbeiha 1 ,
S. D. Fitzgerald 1 , E. W. Braselton 1 , C. M. Otto 2 and A.
B. Downend 2 . 1 Pathobiology and Diagnostic
Investigagtion, Michigan State University, Lansing, MI
and 2 Clinical Sciences, School of Veterinary Medicine,
University of Pennsyllvania, Philadelphia, PA.
#535 SEQUENCE AND EXPRESSION ANALYSIS OF
CANINE ALT1 AND ALT2. L. Nelms, B. Lu and M.
Lawton. Pfizer, Groton, CT.
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SOT’s 44 th Annual Meeting