Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
TUESDAY
#1063 DEVELOPMENTAL EXPOSURE TO LEAD
MODULATES THE OCT-2 TRANSCRIPTION
FACTOR AND ITS TARGET GENES IN THE RAT
HIPPOCAMPUS. S. A. Bakheet and N. H. Zawia.
Biomediacl and Pharmaceutical Sciences, University of
Rhode Island, Kingston, RI.
#1064 MODULATION OF BRAIN CYTOKINE GENE
EXPRESSION BY LEAD. J. Kasten-Jolly, N. Pabello
and D. A. Lawrence. Wadsworth Center, Albany, NY.
#1065 NMDAR SUBUNITS WERE AGGRESSIVELY
REDUCED BY PB-EXPOSURE IN THE EARLY
DEVELOPMENT OF RAT BRAIN. S. xu and B.
Rajanna. Alcorn State University, Alcorn state, MS.
#1066 PRENATAL EXPOSURE TO INHALED
MANGANESE ALTERS DOPAMINERGIC
SUSCEPTIBILITY TO POSTNATAL
METHAMPHETAMINE NEUROTOXICITY. A.
rinderknecht 1 and M. T. Kleinman 2 . 1 Environmental
Health Science and Policy, Univeristy of California,
Irvine, Irvine, CA and 2 Community and Environmental
Medicine, University of California, Irvine, Irvine, CA.
#1067 EFFECTS OF PRENATAL EXPOSURE OF MICE
TO CHROMIUM PICOLINATE, CHROMIUM
CHLORIDE, OR PICOLINIC ACID. M. M. Bailey 1 ,
R. D. Hood 2,1 , J. F. Rasco 1 , J. G. Boohaker 1 , V. Stegall 1 ,
J. J. Jernigan 3 and J. B. Vincent 4 . 1 Department of
Biological Sciences, The University of Alabama,
Tuscaloosa, AL, 2 Ronald D. Hood & Associates,
Toxicology Consultants, Tuscaloosa, AL, 3 Department
of Biology, Stillman College, Tuscaloosa, AL and
4 Department of Chemistry, The University of Alabama,
Tuscaloosa, AL.
#1068 DEXAMETHASONE ALTERS NEURONAL
DEVELOPMENT: CELL ACQUISITION AND
DIFFERENTIATION IN PC12 CELLS. R. R.
Jameson, F. J. Seidler and T. A. Slotkin.
Pharmacol/Cancer Biol, Duke U Med. Ctr, Durham,
NC.
#1069 PRENATAL OR NEONATAL GLUCOCORTICOID
TREATMENT, AT DOSES COMMENSURATE
WITH PHARMACOTHERAPY IN PRETERM
INFANTS, DISRUPTS BRAIN DEVELOPMENT
AND EVOKES LASTING BEHAVIORAL
ABNORMALITIES. M. L. Kreider, E. D. Levin, F. J.
Seidler and T. A. Slotkin. Pharmacology & Cancer
Biology, Duke University Med. Ctr, Durham, NC.
#1070 PERSISTING BEHAVIORAL CONSEQUENCES
OF PRENATAL DOMOIC ACID EXPOSURE IN
RATS. E. D. Levin 1 , K. Pizarro 1 , J. Harrison 1 , W. Pang 1
and J. S. Ramsdell 2 . 1 Department of Psychiatry and
Behavioral Sciences, Duke University Med. Ctr,
Durham, NC and 2 Marine Biotoxins Program, NOAA-
National Ocean Service, Charleston, SC.
#1071 PERINATAL PERCHLORATE EXPOSURE IN
THE RAT: DOES THYROID STATUS AFFECT
BRAIN MORPHOMETRY? S. Schettler 1 , M. R.
Seeley 1 , T. A. Lewandowski 2 and B. D. Beck 1 . 1 Gradient
Corporation, Cambridge, MA and 2 Gradient
Corporation, Seattle, WA.
#1072 BEHAVIORAL EFFECTS ASSOCIATED WITH
CHRONIC DEVELOPMENTAL EXPOSURE TO
KETAMINE OR REMACEMIDE IN RATS. L. K.
Wright 2,1 , C. M. Fogle 1 , E. Pearson 3 , T. Hammond 3 and
M. G. Paule 1,2 . 1 Division of Neurotoxicology, NCTR,
Jefferson, AR, 2 Department of Pharmacology and
Toxicology, University of Arkansas for Medical
Sciences, Little Rock, AR and 3 AstraZeneca Safety
Assessment, Leics, United Kingdom.
#1073 EXPOSURE TO KETAMINE DURING
NEONATAL LIFE INDUCES TRIGGERED
APOPTOTIC NEURODEGENERATION AND
BEHAVIOURAL DEFICITS IN ADULTHOOD. F.
Anders 1 , E. Ponten 2 , T. Gordh 2 and P. Eriksson 1 .
1 Department of Environmental Toxicology, Uppsala
University, Uppsala, Sweden and 2 Department of
Anaesthesiology, Uppsala University, Uppsala, Sweden.
#1074 DEVELOPMENTAL TOXICOLOGY IN THE
NEONATAL MOUSE: THE USE OF RANDOMLY
SELECTED INDIVIDUALS AS STATISTICAL
UNIT COMPARED TO THE LITTER IN MICE
NEONATALLY EXPOSED TO PBDE 99. P.
Eriksson 1 , D. von Rosen 2 , H. Viberg 1 and A.
Fredriksson 1 . 1 Department of Environmental
Toxicology, Uppsala University, Uppsala, Sweden and
2 Department of Biometry and Engineering, Swedish
University of Agricultural Sciences, Uppsala, Sweden.
#1075 POSTNATAL DEVELOPMENTAL
NEUROTOXICITY (DNT): EVALUATION OF P-
MENTHANE 3, 8, DIOL BY DERMAL
ADMINISTRATION IN NEONATAL RATS. J. F.
Barnett 1 , D. B. Learn 1 , A. M. Hoberman 1 , U. Vedula 2
and T. G. Osimitz 3 . 1 Center for Photobiology, Charles
River Discovery and Development Services, Argus
Division, Horsham, PA, 2 S.C. Johnson & Sons, Inc.,
Racine, WI and 3 Science Strategies, LLC,
Charlottesville, VA.
#1076 WATER DISINFECTANT BYPRODUCTS (DBP)
AND ADVERSE PREGNANCY OUTCOMES
(APO): CHLOROACETONITRILE (CAN)
INDUCES GROWTH RESTRICTION AND
ALTERS GENE EXPRESSION IN FETAL BRAIN.
S. Jacob 1 , T. Wood 2 , H. Fouad 1 and A. E. Ahmed 1 .
1 Pathology, University of TX Medical Brach,
Galveston, TX and 2 Molecular Genomics, University of
TX Medical Brach, Galveston, TX.
#1077 METHAMPHETAMINE-INITIATED
NEURODEVELOPMENTAL DEFICITS ARE
ENHANCED IN COCKAYNE SYNDROME B (CSB)
KNOCKOUT MICE. A. W. Wong 1 , W. Jeng 1 and P. G.
Wells 1,2 . 1 Faculty of Pharmacy, University of Toronto,
Toronto, ON, Canada and 2 Department of
Pharmacology, University of Toronto, Toronto, ON,
Canada.
#1078 PERINATAL DIMETHYLTIN EXPOSURE
ALTERS SPATIAL LEARNING ABILITY IN
ADULT RATS. K. D. Ehman 1 , K. L. McDaniel 2 , P. M.
Phillips 2 and V. C. Moser 2 . 1 Curriculum in Toxicology,
UNC, Chapel Hill, NC and 2 NTD/NHEERL, U.S. EPA,
Research Triangle Park, NC.
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SOT’s 44 th Annual Meeting