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44 th Annual Meeting and ToxExpo Program Description Tuesday Morning, March 8 8:30 AM to 11:30 AM Room RO1 WORKSHOP SESSION: NEUROIMAGING STRATEGIES FOR APPLICATION TO NEUROTOXICOLOGY AND RISK ASSESSMENT Chairperson(s): William Slikker, Jr., National Center for Toxicological Research, Jefferson, AR and Tomas Guilarte, Johns Hopkins, Baltimore, MD. Endorsed by: Comparative and Veterinary SS Neurotoxicology SS* Regulatory and Safety Evaluation SS Student Advisory Committee #678 10:55 EARLY BIOMARKERS OF PARKINSON’S DISEASE AS DEFINED BY POSITRON EMISSION TOMOGRAPHY. T. R. Guilarte 1 , M. K. Chen 1 , H. Kuwabara 2 , J. L. McGlothan 1 , M. Alexander 2 , J. R. Brasic 2 , R. J. Adams 3 and D. F. Wong 1,2 . 1 Department Environmental Health Sciences, Johns Hopkins Un, Baltimore, MD, 2 Department Radiology, Johns Hopkins University, Baltimore, MD and 3 Department Comparative Med., Johns Hopkins University, Baltimore, MD. Tuesday Morning, March 8 8:30 AM to 11:30 AM Room 207 TUESDAY Recent technological innovations now make it possible to apply many in vivo neuroimaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) to small animals, including nonhuman primates, rats and mice. The availability of these new technologies coincides with progress in developing animal models of various developmental and neurodegenerative diseases and improvements in assessment protocols for identifying deficits in animals that correlate well with human deficits. The integration of neuroimaging techniques with traditional neurotoxicological assessments has the potential to enhance greatly the ability to relate behavioral, cognitive or motor dysfunction induced by a toxicant to structural and functional brain pathology. Changes in anatomy of soft and hard tissue, metabolism and gene expression can now be done in both a preclinical and a clinical setting using such technologies as Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopy (MRS), Positron Emission Tomography (PET), Computer Tomography Scanning (CT scan) and Visible and Infrared Spectral Imaging. This permits longitudinal studies of the same subject subsequently reducing the number of animals required for studies while providing definitive information as a basis of risk assessment. This workshop will be of interest to toxicologists in general and in particular to neurotoxicologists and risk assessors. #673 8:30 NEUROIMAGING STRATEGIES FOR APPLICATION TO NEUROTOXICOLOGY AND RISK ASSESSMENT. W. Slikker 1 and T. R. Guilarte 2 . 1 Division of Neurotoxicology, NCTR/FDA, Jefferson, AR and 2 Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, MD. #674 8:35 NEUROIMAGING: NEW APPROACHES FOR NEUROTOXICOLOGY. W. Slikker. Division of Neurotoxicology, NCTR/FDA, Jefferson, AR. #675 9:10 MAGNETIC RESONANCE IMAGING OF METALS IN THE BRAIN. D. C. Dorman. CIIT Centers for Health Research, Research Triangle Park, NC. #676 9:45 MOLECULAR IMAGING OF CENTRAL NERVOUS SYSTEM BIOLOGY IN SMALL ANIMALS. M. G. Pomper. Department of Radiology, Pharmacology, and Molecular Sciences and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD. Sponsor: W. Slikker. #677 10:20 MRS TO ASSESS DEVELOPMENTAL NEUROTOXICITY. C. Cloak. Manoa School of Medicine, University of Hawai’i, Honolulu, HI. Sponsor: W. Slikkers, Jr. PLATFORM SESSION: DEVELOPMENTAL TOXICOLOGY Chairperson(s): Anne Greenlee, OHSU, LaGrande, OR and Barbara Abbott, U.S. EPA, Research Triangle Park, NC. #679 8:30 EARLY EXPOSURE TO TCDD IMPAIR RAT BONE TISSUE COMPOSITION AND FUNCTION. M. P. Lind 1 , H. M. Miettinen 2 , J. Orberg 3 , M. Backstrom 1 , I. Pettersson 3,1 , S. Larsson 4 and M. Viluksela 2 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2 Department of Environmental Health, National Public Health Institute, Kuopio, Finland, 3 Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden and 4 Department of Orthopaedics, Uppsala University Hospital, Uppsala, Sweden. Sponsor: G. Johansson. #680 8:50 EXPRESSION OF EGFR AND ITS LIGANDS IN RESPONSE TO TCDD OR RETINOIC ACID IN EGF AND TGFα KO FETAL MOUSE PALATE. B. D. Abbott 1 , H. Boyd 2 , C. Wood 1 and G. Held 1 . 1 Repro. Toxicology. Division, U.S. EPA/ORD/NHEERL, Research Triangle Park, NC and 2 MARC Program, NCCU, Durham, NC. #681 9:10 A ROBUST EXAMINATION OF EFFECTS OF TCDD ON THE DEVELOPING MALE REPRODUCTIVE SYSTEM. D. R. Bell 1 , G. Loizou 2 , S. White 3 , A. Fernandes 3 , M. Rose 3 , B. G. Miller 4 , L. Tran 4 , S. Clode 5 , P. M. Foster 6 and A. MacNicoll 3 . 1 2 Biology, Nottingham, Notts, United Kingdom, HSL, Sheffield, United Kingdom, 3 CSL, York, United Kingdom, 4 IOM, Edinburgh, United Kingdom, 5 6 Covance, Harrogate, United Kingdom and NIEHS, Raleigh, NC. #682 9:30 COMPARISON OF MATRIGEL AND GELATIN SUBSTRATA FOR FEEDER-FREE CULTURE OF UNDIFFERENTIATED MOUSE EMBRYONIC STEM CELLS FOR TOXICITY TESTING. A. R. Greenlee 1,2 , T. A. Kronenwetter-Koepel 2 , S. J. Kaiser 2 and K. Liu 3 . 1 School of Nursing and Center for Research on Occupational and Environmental Toxicology, OHSU, La Grande, OR, 2 Marshfield Clinic Research Foundation, Marshfield, WI and 3 Department of Biostatistics, Forest Research Institute, Jersey City, NJ. 102 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #683 9:50 ALTERED TRANSCRIPTIONAL RESPONSES IN MOUSE EMBRYOS EXPOSED TO BISINDOLYLMALEIMIDE I (BIS I) IN WHOLE EMBRYO CULTURE. E. D. Karoly 1,2 , J. E. Schmid 2 , M. R. Blanton 2 and E. S. Hunter III 2 . 1 Curriculum in Toxicology, UNC Chapel Hill, Chapel Hill, NC and 2 Reproductive Toxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC. #684 10:10 FOLATE PREVENTION OF OXIDATIVE STRESS IN FUMONISIN-INDUCED NEURAL TUBE DEFECTS. J. B. Gelineau-van Waes, J. Wilberding, F. Aleman, L. Bauer and J. Maddox. Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE. Sponsor: G. Bennett. #685 10:30 MATERNAL IMMUNE STIMULATION REDUCES DIABETES INDUCED CRANIOFACIAL MALFORMATIONS. S. D. Holladay 1,2 , T. C. Hrubec 2,1 , R. Prater 2,1 and K. Toops 1 . 1 Veterinary Medicine, Virginia Tech, Blacksburg, VA and 2 Biomedical Sciences, College of Osteopathic Medicine, Blacksburg, VA. #686 10:50 ARSENIC TOXICITY: MOLECULAR AND DEVELOPMENTAL MECHANISMS IN MISCARRIAGE. J. Coffin 1 , W. He 2 , R. J. Greenwell 1 , J. C. Pfau 1 , D. Brooks 1 , M. Bently 3 , T. J. Poole 3 and H. D. Beall 1 . 1 CEHS, University of Montana, Missoula, MT, 2 University of Pittsburg, Pittsburg, PA and 3 SUNY Upstate Medical University, Syracuse, NY. #687 11:10 SYNERGISTIC DEVELOPMENTAL TOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS: TOWARDS A MECHANISTIC UNDERSTANDING. R. Di Giulio 1 , S. Billiard 1 , J. Meyer 3 , D. Wassenberg 1 and P. Hodson 2 . 1 2 Duke University, Durham, NC, Queens University, Kingston, ON, Canada and 3 NIEHS, Research Triangle Park, NC. Tuesday Morning, March 8 8:30 AM to 11:30 AM Room RO8 PLATFORM SESSION: METALS TOXICOLOGY Chairperson(s): Joyce S. Tsuji, Exponent Environmental Group Inc., Bellevue, WA and Michael P. Waalkes, NIEHS, Research Triangle Park, NC. #688 8:30 ARSENIC TRIOXIDE INHIBITS NUCLEAR EXPRESSION OF RXR AND BINDING OF RXR- CONTAINING HETERODIMERS. K. K. Mann, A. M. Padovani and W. H. Miller. Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada. #689 8:50 P53 MODULATES ARSENITE-INDUCED MITOTIC DISRUPTION AND ALTERED GENE EXPRESSION. S. C. McNeely 1 , B. Taylor 1 , X. Xu 1 , W. Zacharias 2,1 , M. J. McCabe 3 and J. States 1 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY, 2 Medicine, University of Louisville, Louisville, KY and 3 Environmental Medicine, University of Rochester, Rochester, NY. #690 9:10 P53 SUPPRESSION OF ARSENITE INDUCED MITOTIC ARREST IS MEDIATED BY P21. B. Taylor 1 , S. C. McNeely 1 , H. L. Miller 1 , M. J. McCabe 2 and J. States 1 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY and 2 Environmental Medicine, University of Rochester, Rochester, NY. #691 9:30 ARSENIC EXPOSURE ACCELERATES ATHEROGENIC CHANGES IN APOE-/- MICE. J. States 1 , S. Srivastava 3 , U. Sen 2 , H. L. Miller 1 and S. E. D’Souza 2 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY, 2 Physiology & Biophysics, University of Louisville, Louisville, KY and 3 Medicine, University of Louisville, Louisville, KY. #692 9:50 EXAMINING BIOMARKERS OF EXPOSURE AND PREPARATION TECHNIQUES FOR ARSENIC QUANTITATION IN BIOLOGICAL STUDIES. B. M. Adair 1 , E. E. Hudgens 2 , R. L. Calderon 2 and D. J. Thomas 1 . 1 Experimental Toxicology Division/NHEERL, U.S. EPA, Research Triangle Park, NC and 2 Human Sudies Division/NHEERL, U.S. EPA, Chapel Hill, NC. #693 10:10 BIOMONITORING OF A COMMUNITY FOR SOIL ARSENIC EXPOSURE. J. S. Tsuji 1 , M. D. Van Kerkhove 2 , C. G. Scrafford 3 and R. S. Kaetzel 1 . 1 2 Exponent, Bellevue, WA, Exponent, New York and 3 Exponent, Washington, DC. #694 10:30 CARCINOGENIC EFFECTS OF CADMIUM CHLORIDE, CISPLATIN AND NICKEL SUBSULFIDE IN METALLOTHIONEIN-I/II DOUBLE KNOCKOUT MICE. M. Waalkes 1 , J. Liu 1 , K. Kasprzak 3 and B. Diwan 2 . 1 Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, 2 NCI at Frederick, Frederick, MD and 3 BRP, SAIC-Frederick, NCI at Frederick, Frederick, MD. #695 10:50 LEAD IS A RISK FACTOR FOR OSTEOARTHRITIS: MOLECULAR MECHANISMS. J. E. Puzas, K. Hochberg, M. Zuscik, T. Sheu, E. Schwarz, R. O’Keefe and R. Rosier. Department of Orthopaedics, University of Rochester School of Medicine, Rochester, NY. #696 11:10 DISSOLUTION RATES OF NANOPARTICULATE METALLIC SPECIES IN ARTIFICIAL HUMAN SWEAT UNDER PHYSIOLOGICALLY RELEVANT CONDITIONS. N. J. Szabo, S. C. Wasdo, G. Brubaker, C. M. Jenkins and S. M. Roberts. University of Florida, Gainesville, FL. TUESDAY up-to-date information at www.toxicology.org 103
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Exhibitors (Continued) 44 th A
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General Information 44 th Annual Me
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2005 Award Winners The Society of T
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2004 Student Award Winners Colgate-
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Author Index (Continued) 44 th Annu
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SOT Affiliates for 2005 44 th Annua
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Program - Society of Toxicology

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