Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#2220 TAXOL INDUCES MUTATIONS IN THE TK
GENE OF L5178Y/TK+/- MOUSE LYMPHOMA
CELLS THROUGH A MITOTIC NON-
DISJUNCTION MECHANISM. M. M. Moore, N.
Mei, L. Chen and T. Chen. Division of Genetic and
Reproductive Toxicology, NCTR/FDA, Jefferson, AR.
#2221 INCREASED GERMLINE MUTATION
FREQUENCIES INDUCED BY ETHYLENE
DICHLORIDE IN MALE MICE. H. J. Daigle and V.
L. Wilson. Biological Science, Louisiana State
University, Baton Rouge, LA.
#2222 MICROARRAY GENE EXPRESSION ANALYSIS
REVEALS DIFFERENCES BETWEEN LARGE
AND SMALL COLONY THYMIDINE KINASE
MUTANTS OF L5178Y MOUSE LYMPHOMA
CELLS. T. Han 1,2 , J. Wang 3 , T. Chen 3 , J. C. Fuscoe 1,2
and M. M. Martha 3 . 1 Center for Functional Genomics,
NCTR/U.S. FDA, Jefferson, AR, 2 Division of Systems
Toxicology, NCTR/U.S. FDA, Jefferson, AR and
3 Division of Genetic and Reproductive Toxicology,
NCTR/U.S. FDA, Jefferson, AR.
#2223 MICRONUCLEUS INDUCTION AND DNA
DAMAGE IN V 79 CELLS IN VITRO BY DUSTS
FROM HARD METAL SINTERING AND
DETONATION COATING PROCESSES. M. J.
Keane and W. E. Wallace. Health Eff. Lab. Division,
NIOSH, Morgantown, WV.
#2224 TRICHLROETHYLENE (TCE) INHALATION
DID NOT INDUCE CYTOGENETIC DAMAGE IN
THE RAT BONE MARROW MICRONUCLEUS
TEST (MNT). J. W. Wilmer, P. J. Spencer, J. G.
Grundy, V. A. Linscombe, S. M. Krieger and B.
Gollapudi. Toxicology & Environmental Research and
Consulting, The Dow Chemical Company, Midland, MI.
#2225 ABILITY OF ALKYLTIN COMPOUNDS TO
PENETRATE CELL MEMBRANES AND ITS
RELATION TO INDUCTION OF GENOTOXIC
EFFECTS IN CHINESE HAMSTER OVARY
(CHO) CELLS. E. Dopp 1 , A. M. Florea 1 , L. M.
Hartmann 2 , B. Shokouhi 1 , U. von Recklinghausen 1 , A.
V. Hirner 2 and A. W. Rettenmeier 1 . 1 Institute of
Hygiene and Occupational Medicine, University of
Duisburg-Essen, Essen, NRW, Germany and 2 Institute
of Environmental Chemistry, University of Duisburg-
Essen, Essen, Germany. Sponsor: E. Nelson.
#2226 RAT ERYTHROCYTE MICRONUCLEUS TEST:
ROLE OF ERYTHROPOIESIS AND EFFECT OF
CIGARETTE MAINSTREAM SMOKE. E. Van
Miert and P. Vanscheeuwijck. PHILIP MORRIS
Research Laboratories bvba, Leuven, Belgium. Sponsor:
H. Haussmann.
#2227 THE EFFECT OF BREVENAL ON DNA DAMAGE
IN HUMAN LYMPHOCYTES INDUCED BY
BREVETOXINS 2 AND 3 (PBTX-2 OR 3). J. E.
Gibson 1,4 , A. N. Sayer 4,1 , A. J. Bourdelais 2 and D. G.
Baden 2,3 . 1 Pharmacology and Toxicology, The Brody
School of Medicine at East Carolina University,
Greenville, NC, 2 Center for Marine Science, University
of North Carolina at Wilmington, Wilmington, NC,
3 Chemistry, University of North Carolina at
Wilmington, Wilmington, NC and 4 Biology, East
Carolina University, Greenville, OR.
#2228 BISPHENOL A-INDUCED DNA DAMAGE IN
C57BL/6N MICE: PRACTICAL IN VIVO
APPLICATIONS OF THE COMET ASSAY. Y. Xu, J.
W. Parton and J. K. Kerzee. MicaGenix, Inc.,
Greenfield, IN.
#2229 THE EFFECT OF PUFF VOLUME ON THE
SPECIFIC ACTIVITY OF CIGARETTE SMOKE
CONDENSATE AS MEASURED IN THE AMES
ASSAY. R. Leverette, M. B. Bennett, J. T. Hamm, M.
Misra, S. V. Vulimiri and S. F. Yee. Lorillard,
Greensboro, NC.
#2230 GENOTOXICITY PROFILES OF COMMON
ALKYL HALIDES AND ALKYL ESTERS. J. J.
Osowski 1 , M. E. Masucci 1 , Z. Kirpnick 2 , E. E.
Rubitski 1 , J. K. Cheung 1 , J. I. Ackerman 1 , W. W. Ku 1 , R.
H. Schiestl 2 and J. Aubrecht 1 . 1 Safety Sciences, Pfizer,
Inc., Groton, CT and 2 Departments of Pathology,
Environmental Health and Radiation Oncology, Geffen
School of Medicine and School of Public Health,
UCLA, Los Angeles, CA.
#2231 DETECTING ANTHRACYCLINE-INDUCED
INTRACHROMOSOMAL RECOMINBINATION
IN SACCHAROMYCES CEREVISIAE USING A
DEL ASSAY. J. Armagost and W. J. Mackay. Biology,
Edinboro University, Edinboro, PA.
#2232 CARCINOGENIC CR(VI) AND THE
NUTRITIONAL SUPPLEMENT CR(III) INDUCE
DNA DELETIONS IN YEAST AND MICE. Z.
Kirpnick, R. Reliene, N. Carls and R. H. Schiestl.
Pathology, David Geffen School of Medicine at UCLA,
Los Angeles, CA.
#2233 YEAST DEL ASSAY DETECTS CLASTOGENS. E.
E. Rubitski 1 , Z. Kirpnick 2 , M. Homiski 1 , M.
Repnevskaya 2 , N. Howlett 3 , R. H. Schiestl 2 and J.
Aubrecht 1 . 1 Safety Sciences, Pfizer, Inc., Groton, CT,
2 Departments of Pathology, Environmental Health and
Radiation Oncology, Geffen School of Medicine and
School of Public Health, UCLA, Los Angeles, CA and
3 Department of Pediatric Oncology, Dana-Farber
Cancer Institute, Boston, MA.
#2234 NUCLEAR LOCALISATION AND DNA REPAIR
CAPACITY OF HOGG1 VARIANTS
POLYMORPHIC AT RESIDUE 326 FOLLOWING
TRANSFECTION OF OGG1 -/- NULL MOUSE
FIBROBLASTS. D. Smart, N. Hodges and K.
Chipman. School of Biosciences, The University of
Birmingham, Birmingham, United Kingdom. Sponsor:
T. Hammond.
#2235 A COMPARATIVE STUDY OF UVB AND UVC
MUTAGENESIS IN DNA REPAIR PROFICIENT
AND MISMATCH REPAIR DEFICIENT (PMS2)
MOUSE CELLS. A. Skinner 2,1 , C. Shin-Darlak 1,2 and
M. Turker 1,2 . 1 Center for Research on Occupational and
Environmental Toxicology, Oregon Health and Sciences
University, Portland, OR and 2 Environmental and
Molecular Toxicology, Oregon State University,
Corvallis, OR.
THURSDAY
up-to-date information at www.toxicology.org 219