Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
Tuesday Morning, March 8
8:30 AM to 11:30 AM
Room RO1
WORKSHOP SESSION: NEUROIMAGING STRATEGIES FOR
APPLICATION TO NEUROTOXICOLOGY AND RISK ASSESSMENT
Chairperson(s): William Slikker, Jr., National Center for Toxicological
Research, Jefferson, AR and Tomas Guilarte, Johns Hopkins, Baltimore, MD.
Endorsed by:
Comparative and Veterinary SS
Neurotoxicology SS*
Regulatory and Safety Evaluation SS
Student Advisory Committee
#678 10:55 EARLY BIOMARKERS OF PARKINSON’S
DISEASE AS DEFINED BY POSITRON
EMISSION TOMOGRAPHY. T. R. Guilarte 1 , M. K.
Chen 1 , H. Kuwabara 2 , J. L. McGlothan 1 , M.
Alexander 2 , J. R. Brasic 2 , R. J. Adams 3 and D. F.
Wong 1,2 . 1 Department Environmental Health Sciences,
Johns Hopkins Un, Baltimore, MD, 2 Department
Radiology, Johns Hopkins University, Baltimore, MD
and 3 Department Comparative Med., Johns Hopkins
University, Baltimore, MD.
Tuesday Morning, March 8
8:30 AM to 11:30 AM
Room 207
TUESDAY
Recent technological innovations now make it possible to apply many in vivo
neuroimaging technologies such as positron emission tomography (PET) and
magnetic resonance imaging (MRI) to small animals, including nonhuman
primates, rats and mice. The availability of these new technologies coincides
with progress in developing animal models of various developmental and
neurodegenerative diseases and improvements in assessment protocols for identifying
deficits in animals that correlate well with human deficits. The
integration of neuroimaging techniques with traditional neurotoxicological
assessments has the potential to enhance greatly the ability to relate behavioral,
cognitive or motor dysfunction induced by a toxicant to structural and functional
brain pathology. Changes in anatomy of soft and hard tissue, metabolism and
gene expression can now be done in both a preclinical and a clinical setting
using such technologies as Magnetic Resonance Imaging (MRI), Magnetic
Resonance Spectroscopy (MRS), Positron Emission Tomography (PET),
Computer Tomography Scanning (CT scan) and Visible and Infrared Spectral
Imaging. This permits longitudinal studies of the same subject subsequently
reducing the number of animals required for studies while providing definitive
information as a basis of risk assessment. This workshop will be of interest to
toxicologists in general and in particular to neurotoxicologists and risk assessors.
#673 8:30 NEUROIMAGING STRATEGIES FOR
APPLICATION TO NEUROTOXICOLOGY AND
RISK ASSESSMENT. W. Slikker 1 and T. R. Guilarte 2 .
1 Division of Neurotoxicology, NCTR/FDA, Jefferson,
AR and 2 Department of Environmental Health Sciences,
Johns Hopkins Medical Institutions, Baltimore, MD.
#674 8:35 NEUROIMAGING: NEW APPROACHES FOR
NEUROTOXICOLOGY. W. Slikker. Division of
Neurotoxicology, NCTR/FDA, Jefferson, AR.
#675 9:10 MAGNETIC RESONANCE IMAGING OF
METALS IN THE BRAIN. D. C. Dorman. CIIT
Centers for Health Research, Research Triangle Park,
NC.
#676 9:45 MOLECULAR IMAGING OF CENTRAL
NERVOUS SYSTEM BIOLOGY IN SMALL
ANIMALS. M. G. Pomper. Department of Radiology,
Pharmacology, and Molecular Sciences and Oncology,
Johns Hopkins University School of Medicine,
Baltimore, MD. Sponsor: W. Slikker.
#677 10:20 MRS TO ASSESS DEVELOPMENTAL
NEUROTOXICITY. C. Cloak. Manoa School of
Medicine, University of Hawai’i, Honolulu, HI.
Sponsor: W. Slikkers, Jr.
PLATFORM SESSION: DEVELOPMENTAL TOXICOLOGY
Chairperson(s): Anne Greenlee, OHSU, LaGrande, OR and Barbara Abbott,
U.S. EPA, Research Triangle Park, NC.
#679 8:30 EARLY EXPOSURE TO TCDD IMPAIR RAT
BONE TISSUE COMPOSITION AND FUNCTION.
M. P. Lind 1 , H. M. Miettinen 2 , J. Orberg 3 , M.
Backstrom 1 , I. Pettersson 3,1 , S. Larsson 4 and M.
Viluksela 2 . 1 Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden, 2 Department
of Environmental Health, National Public Health
Institute, Kuopio, Finland, 3 Department of
Environmental Toxicology, Uppsala University,
Uppsala, Sweden and 4 Department of Orthopaedics,
Uppsala University Hospital, Uppsala, Sweden.
Sponsor: G. Johansson.
#680 8:50 EXPRESSION OF EGFR AND ITS LIGANDS IN
RESPONSE TO TCDD OR RETINOIC ACID IN
EGF AND TGFα KO FETAL MOUSE PALATE. B.
D. Abbott 1 , H. Boyd 2 , C. Wood 1 and G. Held 1 . 1 Repro.
Toxicology. Division, U.S. EPA/ORD/NHEERL,
Research Triangle Park, NC and 2 MARC Program,
NCCU, Durham, NC.
#681 9:10 A ROBUST EXAMINATION OF EFFECTS OF
TCDD ON THE DEVELOPING MALE
REPRODUCTIVE SYSTEM. D. R. Bell 1 , G. Loizou 2 ,
S. White 3 , A. Fernandes 3 , M. Rose 3 , B. G. Miller 4 , L.
Tran 4 , S. Clode 5 , P. M. Foster 6 and A. MacNicoll 3 .
1 2 Biology, Nottingham, Notts, United Kingdom, HSL,
Sheffield, United Kingdom, 3 CSL, York, United
Kingdom, 4 IOM, Edinburgh, United Kingdom,
5 6 Covance, Harrogate, United Kingdom and NIEHS,
Raleigh, NC.
#682 9:30 COMPARISON OF MATRIGEL AND GELATIN
SUBSTRATA FOR FEEDER-FREE CULTURE OF
UNDIFFERENTIATED MOUSE EMBRYONIC
STEM CELLS FOR TOXICITY TESTING. A. R.
Greenlee 1,2 , T. A. Kronenwetter-Koepel 2 , S. J. Kaiser 2
and K. Liu 3 . 1 School of Nursing and Center for
Research on Occupational and Environmental
Toxicology, OHSU, La Grande, OR, 2 Marshfield Clinic
Research Foundation, Marshfield, WI and 3 Department
of Biostatistics, Forest Research Institute, Jersey City,
NJ.
102
SOT’s 44 th Annual Meeting