Program - Society of Toxicology

44 th Annual Meeting
and ToxExpo
Program Description
#1799 DNA DAMAGE AND CYTOGENETIC EFFECTS
OF OCHRATOXIN A IN RATS IN VIVO. A. Mally 1 ,
G. Pepe 2 , S. Ravoori 3 , M. Fiore 2 , R. C. Gupta 3 , P.
Mosesso 2 and W. Dekant 1 . 1 Department of Toxicology,
University of Wuerzburg, Wuerzburg, Germany,
2 Dipartimento die Agrobiologia e Agrochimica,
Universita degli Studi della Tuscia, Viterbo, Italy and
3 Pharmacology&Toxicology, Brown Cancer Center,
University of Louisville, Louisville, KY.
#1800 α 2U -GLOBULIN AND RENAL TUMORS IN
NATIONAL TOXICOLOGY PROGRAM (NTP)
STUDIES. A. M. Doi, G. D. Hill, J. R. Hailey and J. R.
Bucher. NTP, NIEHS, Research Triangle Park, NC.
#1801 THE TSC-2 TUMOR SUPPRESSOR GENE
MODULATES MULTIPLE CELL
PROLIFERATION PATHWAYS. M. T. Labenski 1 , X.
Wei 1 , A. Hunt 1 , G. Tsaprailis 1 , M. S. Chacko 2 , M. D.
Person 2 , J. Shen 2 , S. C. Hensley 3 , T. J. Monks 1 and S. S.
Lau 1 . 1 Pharmacology and Toxicology, University of
Arizona, Tucson, AZ, 2 Pharmacology and Toxicology,
University of Texas at Austin, Austin, TX and
3 UTMDACC, Science Park, Smithville, TX.
#1802 GLOBAL EXPRESSION PROFILING OF MALE
RAT KIDNEY: CO-ADMINISTRATION OF A
SPECIFIC ESTROGEN RECEPTOR (ER)
ANTAGONIST INHIBITS A DYNAMIC 17B-
ESTRADIOL (E2) RESPONSE. P. H. Koza-Taylor 1 ,
G. D. Cappon 4 , J. D. Obourn 3 , J. C. Cook 2 and M. P.
Lawton 1 . 1 MIT, Pfizer, Groton, CT, 2 FD & LS, Pfizer,
Groton, CT, 3 ED, Pfizer, Groton, CT and 4 Toxicology
Sciences, Pfizer, Groton, CT.
#1803 APOPTOSIS, SENESCENCE AND
CYTODIFFERENTIATION IN CARCINOGENIC
MODELING. N. H. Chiu 4 , G. Merlino 2 , K. H. Kim 3 ,
C. J. Kermp 3 and J. Beaubier 5 . 1 NCEADC, U.S. EPA,
Washington, DC, 2 Lab. Molecular Biology, National
Cancer Institute, Bethesda, MD, 3 Division Human Biol,
Public Health Sciences, Fred Hutchinson Cancer
Research Center, Seattle, WA, 4 Office Science
Technology Office of Water, U.S. EPA, Washington, DC
and 5 Office Pesticide Pollution Prevention Toxics, U.S.
EPA, Washington, DC. Sponsor: D. Singh.
#1804 NUMBER OF CRITICAL CELL-CYCLE-EVENTS
IN CANCER DEVELOPMENT OF P53-P27 KO
MICE. N. Chiu 3 , K. H. Kim 2 , C. Kemp 2 and J.
Beaubier 4 . 1 NCEADC, U.S. EPA, Washington DC, DC,
2 Division Human Biology Public Health Sciences, Fred
Hutchindon Cancer Research Center, Seattle, WA,
3 Office Science & Technology, Office of Water, U.S.
EPA, Washington, DC and 4 Office Pollution Prevention
and Toxics, U.S. EPA, Washington, DC. Sponsor: D.
Singh.
#1805 ARNT, A PUTATIVE COACTIVATOR OF C-
MYC/MAX SIGNALING PATHWAY, INTERACTS
WITH C-MYC. R. wu, M. Hoagland and H. Swanson.
University of Kentucky, Lexington, KY.
#1806 A POTENTIAL ROLE FOR C-MYB, BAX AND
THE ARYL HYDROCARBON RECEPTOR IN
BENZENE-INITIATED TOXICITY. H. J. Badham 1
and L. M. Winn 1,2 . 1 Pharmacology and Toxicology,
Queen’s University, Kingston, ON, Canada and 2 School
of Environmental Studies, Queen’s University,
Kingston, ON, Canada.
#1807 THE ESTROGENIC ACTIVITIES OF ARYL
HYDROCARBON RECEPTOR AGONISTS ARE
DUE TO DIRECT ACTIVATION OF ESTROGEN
RECEPTOR α M. Abdelrahim 1 , K. Kim 2 , S. Pearce 3 ,
E. Ariazi 3 , H. Liu 3 , V. Jordan 3 and S. Safe 1,2 . 1 Institute
of Biosciences & Technology, Texas A&M University
System Health Science Center, Houston, TX,
2 Veterinary Physiology & Pharmacology, Texas A&M
University, College Station, TX and 3 Robert H. Lurie
Comprehensive Cancer Center, Northwestern
University, Chicago, IL.
#1808 INHIBITION OF ESTROGEN RECEPTOR-
NEGATIVE BREAST CANCER CELL GROWTH
BY ARYL HYDROCARBON RECEPTOR
AGONISTS. L. Kotha and S. Safe. Veterinary
Physiology & Pharmacology, Texas A&M University,
College Station, TX.
#1809 CONSEQUENCES OF INTERACTION OF THE
EQUINE ESTROGEN METABOLITE, 4-
HYDROXYEQUILENIN, WITH ESTROGEN
RECEPTOR α M. Chang and J. L. Bolton. University
of Illinois at Chicago, Chicago, IL.
#1810 G2/M BLOCK OF PRIMARY MAMMARY
EPITHELIAL CELLS FROM PRE-MENOPAUSAL
WOMEN IN RESPONSE TO GENOTOXIC
CARCINOGEN EXPOSURE. J. Brooks 1 , J. Wang 1 ,
A. Humphrey 1 , J. Hearnes 2 , J. Pietenpol 2 , J. Price 2 and
S. E. Eltom 1 . 1 Pharmacology, Meharry Medical College,
Nashville, TN and 2 Vanderbilt University, Nashville,
TN.
#1811 CHANGES IN ESTROGEN METABOLISM IN
CATECHOL-O-METHYLTRANSFERASE (COMT)
DEFICIENT MICE ARE ASSOCIATED WITH
INCREASED DEVELOPMENT AND ALTERED
GENE EXPRESSION IN THE MOUSE
MAMMARY GLAND. C. Borgeest 1 , C. A. Zahnow 2 ,
S. O. DaCosta 1 , B. L. McAtee 1 , J. A. Flaws 3 , J. K.
Babus 3 , S. Biswal 1 and J. D. Yager 1 . 1 Environmental
Health Science, Johns Hopkins University, Baltimore,
MD, 2 Cancer Biology, Johns Hopkins University,
Baltimore, MD and 3 Department of Epidemiology and
Preventive Medicine, University of Maryland,
Baltimore, MD.
#1812 INVESTIGATION OF
OCTAMETHYLCYCLOTETRASILOXANE (D4)
AND DECAMETHYLCYCLOPENTASILOXANE
(D5) AS DOPAMINE D2-RECEPTOR AGONISTS.
P. A. Jean, K. A. McCracken, J. A. Arthurton and K. P.
Plotzke. Dow Corning Corporation, Midland, MI.
#1813 TRANSPLACENTAL AND POSTNATAL
EXPOSURE OF AIDS DRUGS ZIDOVUDINE
(AZT) AND LAMIVUDINE (3TC) IN
C3B6F 1 TRP53(+/-) TRANSGENIC MICE. F. W. Lee,
S. M. Lewis, C. Crawford, W. T. Allaben and J. E.
Leakey. U.S. FDA, NCTR, Jefferson, AR.
WEDNESDAY
up-to-date information at www.toxicology.org 187