Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description TUESDAY 3:20 PM Funding Alternatives to NIH: Being Creative, Jean F. Regal, University of Minnesota Medical School, Duluth, MN. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Room RO1 SYMPOSIUM SESSION: THE AHR IN CELL GROWTH AND DEATH Chairperson(s): David Sherr, Boston University School of Public Health, Boston, MA and Prakash Nagarkatti, Virginia Commonwealth University, Richmond, VA. Endorsed by: Immunotoxicology SS Since its first description as a dioxin-binding protein in the 1980s, the aryl hydrocarbon receptor (AhR) has been studied primarily for its control of biologic responses to environmental agonists. However, in the last few years it has become apparent that the AhR, which clearly did not evolve to recognize environmental pollutants, likely plays an important physiologic function. Indeed, the ability of the AhR to directly regulate important cellular genes and factors such as Bax, the estrogen receptor, Rb, and NF-kB hints at a critical role for the AhR in cell growth and death. The presence of constitutively active AhR in cells that exhibit aberrant growth and apoptosis regulation, i.e. neoplastic cells, further supports this hypothesis. In this symposium we will present several examples of AhR-mediated control of cell growth and death and will begin to detail the molecular mechanisms through which this control is manifest. In some studies presented herein, AhR function is revealed with exogenous agonists such as TCDD or PAH. In other cases, constitutive AhR function is demonstrated by modulation of AhR expression and activity in the absence of exogenous ligands. In all cases, the roles that the AhR may play in normal cellular physiology and the consequences of disrupting these functions with environmental agonists are discussed. #990 1:30 THE AHR IN CELL GROWTH AND DEATH. D. H. Sherr 1 and P. Nagarkatti 2 . 1 Environmental Health, Boston University School of Public Health, Boston, MA and 2 Department of Pharmacology and Toxicology, Virginia Commonwealth Unviersity, Richmond, VA. #991 1:40 LIGATION OF AHR LEADS TO UP- REGULATION OF APOPTOTIC GENES THROUGH DRE-DEPENDENT AND - INDEPENDENT PATHWAYS INVOLVING NF-KB AND CONSEQUENT INDUCTION OF APOPTOSIS IN THYMOCYTES. P. S. Nagarkatti. Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA. #992 2:10 AHR CONTROL OF B LYMPHOCYTE DEATH AND GROWTH. S. H. David, H. Ryu, J. K. Emberley, L. L. Allan and J. J. Schlezinger. Environmental Health, Boston University School of Public Health, Boston, MA. #993 2:40 REGULATION OF MAMMARY TUMOR GROWTH THROUGH THE ARYL HYDROCARBON RECEPTOR. S. H. Safe. Veterinary Physiology, Texas A & M University, College Station, TX. #994 3:10 CURRENT INSIGHTS INTO AHR-MEDIATED LIVER CELL CYCLE CONTROL. C. J. Elferink. Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX. Sponsor: D. Sherr. #995 3:40 AHR CONTROL OF APOPTOSIS INDUCED BY AGENTS CAUSING LYSOSOMAL DAMAGE. J. J. Reiners. Institute of Environmental Health Sciences, Wayne State University, Detroit, MI. Sponsor: D. Sherr. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM Room RO4 SYMPOSIUM SESSION: ORGANOPHOSPATES & CARBMATES: CHOLINERGIC VS. NONCHOLINERGIC MECHANISMS Chairperson(s): Ramesh Gupta, Murray State University, Hopkinsville, KY and Carey N. Pope, Oklahoma State University, Stillwater, OK. Endorsed by: Comparative and Veterinary SS Neurotoxicology SS* Risk Assessment SS Student Advisory Committee Organophosphates (OPs) and carbamates (CMs) are commonly used as pesticides in agriculture, industry, and around the home/garden. Some OPs have also been used in chemical warfare and terrorism, while some CMs have been used to treat diseases such as myasthenia gravis and dementia. Interestingly, the CM pyridostigmine is used prophylactically to protect soldiers from possible OP nerve agent exposure. Many compounds of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. While these compounds have a wide variety of toxic effects, neurotoxicity elicited by inhibition of acetylcholinesterase (AChE) is generally of primary concern. In recent years, a variety of novel mechanisms for OPs and CMs have been proposed which may modulate cholinergic neurotoxicity or lead to non-cholinergic effects. Molecular studies of AChE and its interaction with inhibitors has allowed a more thorough characterization of the structure, function, and regulation of this enzyme. In vitro studies indicate that NGF-differentiated SY5Y cells may distinguish between OPs that produce OPIDN and those that do not, and may therefore be a suitable mechanistic model for exploring the effects of different classes of OPs. Evidence suggests that while cholinergic mechanisms play a critical role in the initial stage of cholinergic toxicity, neuronal damage/death may occur through non-cholinergic mechanisms including oxidative stress. The Food Quality Protection Act of 1996 requires EPA to consider the cumulative risk to pesticides with a common mechanism of action. In the case of OPs and CMs, this common mechanism is initiated by inhibition of AChE (via phosphorylation or carbamylation, respectively). However, noncholinergic mechanisms are not currently considered in risk assessment. This symposium will review the latest developments in understanding of molecular mechanisms (cholinergic and non-cholinergic) for these toxicants, as well as discuss current strategies of cumulative risk assessment for pesticides acting through a common mechanism. #996 1:30 ORGANOPHOSPHATES & CARBAMATES: CHOLINERGIC & NONCHOLINERGIC MECHANISMS. R. C. Gupta. Toxicology, Murray State University, Hopkinsville, KY. #997 1:40 CONTEMPORARY PROTEOMICS IN ACETYLCHOLINESTERASE AND RELATED α, β HYDROLASE-FOLD PROTEINS AS TARGETS OF TOXICOLOGICAL MANIFESTATIONS AND GENETIC DISORDERS. P. Taylor, Z. Radic, L. Jennings and S. Camp. Pharmacology, University of California, San Diego, La Jolla, CA. Sponsor: R. Gupta. 126 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #998 2:10 ORGANOPHOSPHORUS AND CARBAMATE CHOLINESTERASE INHIBITORS: USES AND MISUSES OF A COMMON MECHANISM. C. N. Pope. Physiological Sciences, Oklahoma State University, Stillwater, OK. #999 2:40 IN VITRO MODELS FOR TESTING NEUROTOXICITY OF ORGANOPHOSPHORUS COMPOUNDS AND PROTECTIVE EFFECTS OF OP HYDROLASE. E. Tiffany-Castiglioni. Veterinary Anatomy and Public Health, Texas A&M University, College Station, TX. #1000 3:10 OXIDATIVE STRESS INVOLVEMENT IN NEUROTOXICITY OF ORGANOPHOSPHATES AND CARBAMATES. R. C. Gupta 1 , S. Milatovic 2 , T. J. Montine 2 , W. D. Dettbarn 3 and D. Milatovic 2 . 1 Toxicology, Murray State University, Hopkinsville, KY, 2 University of Washington, Seattle, WA and 3 Vanderbilt University, Nashville, TN. #1001 3:40 EPA PERSPECTIVE: SCIENTIFIC APPROACHES FOR ASSESSING THE CUMULATIVE RISK OF ORGANOPHOSPHORUS AND N-METHYL CARBAMATE CHOLINESTERASE INHIBITING PESTICIDES. A. Lowit. Office of Pesticide Programs, U.S. EPA, Washington, DC. Sponsor: R. Gupta. Tuesday Afternoon, March 8 1:30 PM to 4:30 PM La Louisiane Ballroom B SYMPOSIUM SESSION: PROTEOMICS AND ANTIBODY MICROARRAYS: APPLICATIONS IN TOXICOLOGY Chairperson(s): Richard Zangar, Pacific Northwest Laboratories, Richland, WA and Alex Merrick, National Institute for Envirornmental Health Sciences, Research Triangle Park, NC. #1003 1:35 ANALYSIS OF MARKERS OF CANCER AND XENOBIOTIC EXPOSURE USING ANTIBODY MICROARRAYS. R. C. Zangar 1 , S. M. Varnum 1 , D. S. Daly 1 , A. M. White 1 , C. Y. Covington 2 , S. Wiley 1 , B. D. Thrall 1 and R. D. Stenner 1 . 1 Pacific Northwest National Laboratory, Richland, WA and 2 University of California School of Nursing, Los Angeles, CA. #1004 2:10 FINDING NEW SIGNAL TRANSDUCTION PARADIGMS USING PROTEIN-DOMAIN MICROARRAY. M. T. Bedford, A. Espejo and J. Daniel. MD Anderson Cancer Center, Bastrop, TX. Sponsor: R. Zanger. #1005 2:45 PROTEOMIC ANALYSIS OF SERUM PROTEINS DURING ACUTE ACETAMINOPHEN TOXICITY IN RATS REVEALS ACUTE PHASE AND ANTIOXIDANT RESPONSE. B. A. Merrick 1 , K. B. Tomer 1 , M. E. Bruno 1 , J. H. Madenspacher 1 , B. A. Wetmore 1 , R. Pieper 2 , C. L. Gatlin 2 , M. M. Andrew 2 , A. J. Makusky 2 , M. Zhao 2 , J. Zhou 2 , J. Taylor 2 , S. Steiner 2 and R. W. Tennant 1 . 1 NCT, NIEHS, Research Triangle Park, NC and 2 Proteomics, LSBC, Germantown, MD. #1006 3:20 IDENTIFYING PROTEIN MODIFICATIONS RESULTING FROM OXIDATIVE STRESS USING LC/ESI/MS. I. A. Blair, S. Lee and T. Oe. Pharmacology, University of Pennsylvania, Philadephia, PA. Sponsor: R. Zanger. #1007 3:55 COMPARATIVE PROTEOMIC ANALYSIS OF CONTROL AND TUMOR-BEARING MOUSE PLASMA BY GEL-LC-MS/MS. S. R. Tannenbaum, V. B. Bhat, M. Choi and J. S. Wishnok. Biological Engineering Division, MIT, Cambridge, MA. TUESDAY Endorsed by: Mechanisms SS* Molecular Biology SS Student Advisory Committee It is now possible to sequence a whole genome and predict the complete proteome of an organism. This information, when used in combination with sophisticated techniques for protein analysis such as tandem mass spectrometry (MS), allows for the rapid analysis of hundreds or thousands of proteins in a single biological sample. These proteomic technologies offer the ability to rapidly determine which of the identified proteins are altered in response to toxicity, xenobiotic exposure or various disease states. One specialized application of proteomics technology is the analysis of protein modifications. Since many of the toxic effects of xenobiotic exposure and oxidative stress are associated with covalent protein modifications, this area of research is expected to result in significant advances in our understanding of the molecular basis for toxicity. Another rapidly developing technology is protein arrays, which can be used for broad comparisons of protein-protein interactions or quantitative analyses. In comparison to MS-based analyses, protein microarrays generally have greater throughput but are limited to a select group of proteins. Overall, these developing technologies are expected to provide a broader insight into the mechanisms of toxicity and identify new markers of disease and toxicity. #1002 1:30 PROTEOMICS AND ANTIBODY MICROARRAYS: APPLICATIONS IN TOXICOLOGY. R. C. Zangar. Pacific Northwest National Laboratory, Richland, WA. up-to-date information at www.toxicology.org 127
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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