Program - Society of Toxicology

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44 th Annual Meeting and ToxExpo Program Description WEDNESDAY Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: STEROID RECEPTORS Chairperson(s): Timothy Zacharewski, Michigan State University, East Lansing, MI. Displayed: 1:30 PM–4:30 PM Attended: 3:00 PM–4:30 PM #1760 TEMPORAL GENE EXPRESSION ANALYSIS OF MOUSE HEPA-1C1C7 CELLS TREATED WITH 17β-ESTRADIOL BY CDNA MICROARRAY. C. J. Fong, L. D. Burgoon, R. Gupta, D. G. Humes and T. R. Zacharewski. Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI. #1761 CONSTITUTIVE ANDROSTANE RECEPTOR (CAR)-DEPENDENT HEPATIC INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES (UGTS) IN WISTAR-KYOTO RATS BY CYP2B INDUCERS. M. K. Shelby 1 , A. L. Slitt 1 , N. J. Cherrington 2 and C. D. Klaassen 1 . 1 University of Kansas Medical Center, Kansas City, KS and 2 University of Arizona, Tucson, AZ. #1762 HEPATIC INDUCTION OF MOUSE UDP- GLUCURONOSYLTRANSFERASE (UGT) MNRA EXPRESSION BY PROTOTYPICAL ACTIVATORS OF VARIOUS TRANSCRIPTION PATHWAYS. D. B. Buckley, J. S. Petrick and C. D. Klaassen. University of Kansas Medical Center, Kansas City, KS. #1763 INDUCIBILITY OF MOUSE TRANSCRIPTION FACTORS THAT REGULATE HEPATIC METABOLISM AND TRANSPORT. J. S. Petrick, D. B. Buckley and C. D. Klaassen. University of Kansas Medical Center, Kansas City, KS. #1764 VITAMIN D-INTERACTING PROTEIN 150 (DRIP150) COACTIVATION OF ESTROGEN RECEPTOR α (ERα) IN ZR-75 BREAST CANCER CELLS IS INDEPENDENT OF LXXLL MOTIFS. J. Lee 1 , K. Kim 1 and S. Safe 1,2 . 1 Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX and 2 Institute of Biosciences & Technology, Texas A&M University System Health Science Center, Houston, TX. #1765 GLUCOCORTICOID RECEPTOR AND STEROID AND XENOBIOTIC RECEPTOR (SXR) REGULATION OF SXR PROMOTER ACTIVITY. L. M. Tompkins and A. D. Wallace. Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC. #1766 HEPATOCYTE RXRALPHA REGULATES THE EXPRESSION OF THE GLUTATHIONE S- TRANSFERASE GENES AND MODULATES ACETAMINOPHEN-GLUTATHIONE CONJUGATION IN MOUSE LIVER. Y. Y. Wan, N. Chou, L. He, M. Gyamfi, A. J. Mendy and G. Dai. Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS. #1767 P38 MITOGEN-ACTIVATED PROTEIN KINASE IS INVOLVED IN CONSTITUTIVE ANDROSTANE RECEPTOR SIGNALING TO REGULATE CYP2B INDUCTION BY XENOBIOTICS. F. Zhang, H. B. Hoffman and L. You. CIIT, Research Triangle Park, NC. #1768 EVIDENCE FOR CAR-DEPENDENT HEPATOCELLULAR PROLIFERATION IN TCPOBOP-TREATED CONSTITUTIVE ANDROSTANE RECEPTOR KNOCKOUT (CAR -/- ) MICE. D. M. Nelson, V. Bhaskaran, B. Gemzik, B. D. Car and L. D. Lehman-McKeeman. Discovery Toxicology, Bristol-Myers Squibb, Princeton, NJ. #1769 EFFECTS OF 2, 2’, 4, 4, ‘- TETRABROMODIPHENYL ETHER ON CAR AND PXR REGULATED GENE EXPRESSION IN WEANLING FEMALE RATS. V. M. Richardson 1 , K. M. Crofton 2,1 and M. J. DeVito 1 . 1 ORD/NHEERL/ETD/PKB, U.S. EPA, Research Triangle Park, NC and 2 ORD/NHEERL/ETD/NTD, U.S. EPA, Research Triangle Park, NC. #1770 TRANSCRIPTIONAL ACTIVATION OF CREATINE KINASE GENE EXPRESSION BY INSULIN-LIKE GROWTH FACTOR (IGF-I). F. Wang 1 and S. Safe 2 . 1 OB/GYN, The State University of New York, Buffalo, NY and 2 Veterinary Physiology & Pharmacology, Texas A&M University, College Station, TX. #1771 ANALYSIS OF GENE EXPRESSION DURING UTERINE INDUCTION AND REGRESSION IN IMMATURE, OVARIECTOMIZED RATS FOLLOWING TREATMENT WITH ETHYNYL ESTRADIOL. J. C. Kwekel, H. A. Dalgleish, L. D. Burgoon, J. R. Harkema and T. R. Zacharewski. Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI. #1772 EFFECTS OF ESTROGEN ON IMMATURE, OVARIECTOMIZED MICE: A MULTI- APPROACH, TISSUE-BY-TISSUE COMPARISON. J. W. Burt 1,2 , L. D. Burgoon 2 , D. G. Humes 1 , J. C. Kwekel 1,2 , A. S. Harney 1 , J. R. Harkema 3 and T. R. Zacharewski 1,2 . 1 Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 2 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 3 Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI. #1773 REGULATION OF TRANSCRIPTIONAL ACTIVATION OF LARGEMOUTH BASS ESTROGEN RECEPTORS ALPHA, BETA 1 AND BETA 2 BY ESTRADIOL AND THE CONTAMINANTS NONYLPHENOL AND METHOXYCHLOR IN HEPG2 CELLS. N. Denslow 1 , J. Blum 1 and T. Sabo-Attwood 2 . 1 University of Florida, Gainesville, FL and 2 University of Vermont, Burlington, VT. 184 SOT’s 44 th Annual Meeting
44 th Annual Meeting and ToxExpo Program Description #1774 ESTROGEN INFLUENCES THE GROWTH OF CELLS THROUGH MODULATING THE INTRACELLULAR REDOX STATE. Q. Felty and D. Roy. Environmental & Occupational Health, Florida International University, Miami, FL. #1775 THE EFFECT OF POLYCHLORINATED BIPHENYLS (PCBs) ON THYROID HORMONE RECEPTOR (TR) AND CO-REGULATOR INTERACTIONS ON DNA. S. You 1 , K. Gauger 1 and R. Zoeller 2,1 . 1 Molecular & Cellular Biology Program, University of Massachusetts, Amherst, MA and 2 Biology, University of Massachusetts, Amherst, MA. Wednesday Afternoon, March 9 1:30 PM to 4:30 PM Exhibit Hall POSTER SESSION: PHARMACEUTICALS-METABOLIC/CANCER Chairperson(s): Thomas Mably, Bristol Meyers Squibb Co, Evansville, IN. Displayed: 1:30 PM–4:30 PM Attended: 1:30 PM–3:00 PM #1776 GENETIC TOXICOLOGY AND BONE MARROW CYTOTOXICITY STUDIES OF THE CORTICOTROPIN-RELEASING HORMONE (CRH) RECEPTOR ANTAGONIST, ANTALARMIN. P. T. Curry 1 , M. Nagabhushan 1 , D. L. McCormick 1 , R. E. Parchment 2 , K. Calis 3 , P. W. Gold 3 , G. Cizza 3 , D. Charney 3 , E. R. Glaze 4 and J. E. Tomaszewski 4 . 1 IIT Research Institute, Chicago, IL, 2 SciTech Development LLC, Grosse Pointe, MI, 3 National Institute of Mental Health, Bethesda, MD and 4 National Cancer Institute, Bethesda, MD. #1777 SUBCHRONIC ORAL TOXICITY OF THE CORTICOTROPIN-RELEASING HORMONE (CRH) RECEPTOR ANTAGONIST, ANTALARMIN, IN DOGS. W. D. Johnson 1 , J. Harder 1 , D. L. McCormick 1 , R. L. Morrissey 2 , K. Calis 3 , P. W. Gold 3 , G. Cizza 3 , D. Charney 3 , E. R. Glaze 4 and J. E. Tomaszewski 4 . 1 IIT Research Institute, Chicago, IL, 2 Pathology Associates, Chicago, IL, 3 National Institute of Mental Health, Bethesda, MD and 4 National Cancer Institute, Bethesda, MD. #1778 SUBCHRONIC ORAL TOXICITY OF THE CORTICOTROPIN-RELEASING HORMONE (CRH) RECEPTOR ANTAGONIST, ANTALARMIN, IN RATS. T. L. Horn 1 , W. D. Johnson 1 , D. L. McCormick 1 , R. L. Morrissey 2 , K. Calis 3 , P. W. Gold 3 , G. Cizza 3 , D. Charney 3 , E. R. Glaze 4 and J. E. Tomaszewski 4 . 1 IIT Research Institute, Chicago, IL, 2 Pathology Associates, Chicago, IL, 3 National Institute of Mental Health, Bethesda, MD and 4 National Cancer Institute, Bethesda, MD. #1780 REPEAT DOSE TOXICITY STUDIES IN RATS AND DOGS WITH TH0318, A DPP IV-RESISTANT ANALOG OF NATURAL GLP-1. S. Fennell 1 , H. Loughrey 1 , M. Garino 1 , S. Abdullah 1 , M. Stilianesis 2 , K. Arjah 2 , B. Vu 2 and E. Ferdinandi 1 . 1 Theratechnologies, Inc., Saint Laurent (Montreal), QC, Canada and 2 CTBR Bio-Research Inc., Senneville, QC, Canada. Sponsor: C. Banks. #1781 CARCINOGENICITY EVALUATION OF ATAZANAVIR IN MICE. T. A. Mably 1 , T. P. Sanderson 1 , C. D. Houle 2 , B. E. Schilling 1 and M. A. Dominick 1 . 1 Drug Safety Evaluation, Bristol-Myers Squibb Co., Mt.Vernon, IN and 2 Experimental Pathology Laboratories, Inc., Research Triangle Park, NC. #1782 MULTIPLE DOSE TOXICITY STUDY OF IMEXON IN FISCHER 344 RATS. Y. Chen 1 , E. Glaze 2 , J. Tomaszewski 2 , R. Morrissey 3 and A. Lyubimov 1 . 1 Toxicology Research Laboratory, University of Illinois at Chicago, Chicago, IL, 2 Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD and 3 Pathology Associates Division, Charles River Laboratories, Chicago, IL. #1783 SEQUENCE DEPENDENT ANTAGONISM BETWEEN RALOXIFENE, 5-FLUOROURACIL AND PEMETREXED. E. Fryar 1 , D. H. Jillian 1 , S. M. William 2 and B. Donnell 1 . 1 Pharmacology, Howard University, Washington, DC and 2 Biochemistry, Howard University, Washington, DC. #1784 UTILIZATION OF MULTIPLE ENDPOINTS TO INVESTIGATE DIFFERENTIAL TOXICITY PRODUCED BY TOPOISOMERASE II INHIBITORS, DOXORUBICIN AND ETOPOSIDE. R. T. Dunn, E. S. Galambos, L. Healy, R. Morgan, J. Yamada, H. Hamadeh, A. Kwok, M. E. Cosenza and C. Afshari. Toxicology, Amgen Inc., Thousand Oaks, CA. #1785 ORAL TOXICITY STUDY OF A RETINOIC ACID ANALOGUE, 9-CIS-UAB-30, IN RATS. R. Krishnaraj 1 , A. Lyubimov 1 , C. Detrisac 2 , I. Kapetanovic 3 , J. Crowell 3 , W. Brouillette 4 and D. Muccio 4 . 1 Pharmacology, University of Illinois at Chicago, Chciago, IL, 2 Pathology Associates, Chciago, IL, 3 National Cancer Institute, Bethesda, MD and 4 Chemistry, University of Alabama at Birmingham, Birmingham, AL. WEDNESDAY #1779 CYPROHEPTADINE AND CYCLIZINE INHIBIT INSULIN SECRETION IN RIN5F CELLS BY INHIBITING CALCIUM CHANNELS. M. Otieno 1 , N. Bavuso 1 , A. Katein 1 , T. Kelly 1 , J. Milano 1 and F. Pognan 2 . 1 Safety Assessment US, AstraZeneca Pharmaceuticals, Wilmington, DE and 2 Safety Assessment UK, AstraZeneca Pharmaceuticals, Alderly Park, United Kingdom. up-to-date information at www.toxicology.org 185
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Contents Program Overview .........
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Annual Meeting Events Calendar (Con
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Sheraton Hotel Map 44 th Annual Mee
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Itinerary Planner Computer Stations
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2005 Award Winners The Society of T
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INTERNATIONAL HARMONIZATION OF TECH
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Saturday Afternoon, March 5 2:00 PM
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Program - Society of Toxicology

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